TSNAX-DISC1

Summary

Gene Symbol: TSNAX-DISC1
Description: TSNAX-DISC1 readthrough (NMD candidate)
Species: human

Top Publications

  1. pmc Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
    Gary W Beecham
    Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Am J Hum Genet 84:35-43. 2009
  2. pmc Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E Landers
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital East, Building 114, Navy Yard, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9004-9. 2009
  3. pmc Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
    M A Carless
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Mol Psychiatry 16:1096-104, 1063. 2011
  4. pmc Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial
    Rachel Wade
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Haematologica 96:1496-503. 2011
  5. ncbi Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Department of Medical Sciences, The University of Edinburgh, Scotland, United Kingdom
    Genomics 67:69-77. 2000
  6. doi Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:844-9. 2010
  7. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009

Scientific Experts

  • Melanie Carless
  • J Kirsty Millar
  • Alexandra Schosser
  • Rachel Wade
  • Gary W Beecham
  • Kenji Nakata
  • John E Landers
  • Davide Rossi
  • Gianluca Gaidano
  • Richard S Houlston
  • Sue Richards
  • David G Oscier
  • Dalemari Crowther-Swanepoel
  • Daniel Catovsky
  • Maria Chiara Di Bernardo
  • Claire L Simpson
  • P Nigel Leigh
  • Ildefonso Rodriguez-Leyva
  • Robert H Brown
  • Thomas M Hyde
  • Yoshitatsu Sei
  • Pilar Galan
  • Leonard H van den Berg
  • Radhakrishna Vakkalanka
  • Orla Hardiman
  • Joel E Kleinman
  • Jonathan D Glass
  • Michael A van Es
  • Nicole Couture
  • Alayna Barnes-Nessa
  • Eden R Martin
  • Franck Georges
  • Judith Melki
  • Margaret A Pericak-Vance
  • Thomas J Kwiatkowski
  • Christiaan G J Saris
  • Christopher E Shaw
  • Valerie K Hansen
  • Tianzhang Ye
  • Daniel R Weinberger
  • Erin N Newburn
  • Yi Ju Li
  • Michael A Slifer
  • Philippe Corcia
  • Paul W J Van Vught
  • Simon Heath
  • Ammar Al-Chalabi
  • John H J Wokke
  • Aslihan Ozoguz
  • Maxim Barenboim
  • Meraida Polak
  • Adrian J Ivinson
  • Frank P Diekstra
  • Peter C Sapp
  • Wendy J Broom
  • Vincent Meininger
  • Vincenzo Silani
  • Francois Salachas
  • Lijia Shi
  • Hylke M Blauw
  • Nicola Ticozzi
  • Jan H Veldink
  • Barbara K Lipska
  • Diane M McKenna-Yasek
  • Betsy A Hosler
  • Ting Jan Cho
  • Anne Marie Wills
  • John R Gilbert
  • John F Powell
  • H Robert Horvitz
  • Yukitaka Morita
  • Roel A Ophoff
  • Jonathan L Haines
  • Mark Lathrop
  • Simon Cronin
  • Shaun Purcell

Detail Information

Publications7

  1. pmc Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease
    Gary W Beecham
    Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Am J Hum Genet 84:35-43. 2009
    ..These results help to further define the genetic architecture of LOAD...
  2. pmc Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E Landers
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital East, Building 114, Navy Yard, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9004-9. 2009
    ..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability...
  3. pmc Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes
    M A Carless
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Mol Psychiatry 16:1096-104, 1063. 2011
    ..93 × 10(-4)) and panic (rs12137417, P=7.41 × 10(-4)) were associated with DISC1 sequence variation. DISC1 has well-defined genetic regulation and clearly influences important phenotypes related to psychiatric disease...
  4. pmc Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial
    Rachel Wade
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Haematologica 96:1496-503. 2011
    ..Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease...
  5. ncbi Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Department of Medical Sciences, The University of Edinburgh, Scotland, United Kingdom
    Genomics 67:69-77. 2000
    ..1. The TRAX gene consists of six exons with a putative CpG island at the 5' end. Four major transcripts are produced from this gene, of which the smallest, at 2.7 kb, had previously been identified...
  6. doi Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:844-9. 2010
    ....
  7. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...