TRPV1

Summary

Gene Symbol: TRPV1
Description: transient receptor potential cation channel subfamily V member 1
Alias: VR1, transient receptor potential cation channel subfamily V member 1, OTRPC1, capsaicin receptor, osm-9-like TRP channel 1, transient receptor potential vanilloid 1a, transient receptor potential vanilloid 1b, vanilloid receptor subtype 1
Species: human

Top Publications

  1. doi A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid
    Joel Castro
    Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia 5001, Australia
    Biochem J 418:553-66. 2009
  2. ncbi Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis
    Andrea Engler
    Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, Gloriastrasse 25, Zurich, Switzerland
    Biochem Biophys Res Commun 359:884-8. 2007
  3. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  4. ncbi A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
  5. pmc Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
    E Mezey
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Basic Neuroscience Program, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3655-60. 2000
  6. ncbi Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
    P Hayes
    Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK
    Pain 88:205-15. 2000
  7. ncbi Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1
    Z Olah
    Neuronal Gene Expression Unit, Pain and Neurosensory Mechanisms Branch, NIDCR, the Laboratory of Cellular Carcinogenesis and Tumor Promotion, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:11021-30. 2001
  8. ncbi Analysis of the native quaternary structure of vanilloid receptor 1
    N Kedei
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:28613-9. 2001
  9. ncbi Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
    Mitsuko Numazaki
    Department of Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    J Biol Chem 277:13375-8. 2002
  10. ncbi TRPV3 is a temperature-sensitive vanilloid receptor-like protein
    G D Smith
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK
    Nature 418:186-90. 2002

Research Grants

  1. KATHRYN MARIE ALBERS; Fiscal Year: 2014
  2. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
  3. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
  4. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
  5. DUSTIN PEPPER GREEN; Fiscal Year: 2014
  6. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2012
  7. Serotonin Modulation of Trigeminal Nociceptors
    DAYNA RUTH LOYD; Fiscal Year: 2010
  8. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
  9. MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2014
  10. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012

Detail Information

Publications208 found, 100 shown here

  1. doi A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid
    Joel Castro
    Department of Medical Biochemistry, School of Medicine, Flinders University, Adelaide, South Australia 5001, Australia
    Biochem J 418:553-66. 2009
    ..a putative sub-compartment of the ER in SOC activation in liver cells was investigated using ectopically expressed TRPV1 (transient receptor potential vanilloid 1), a non-selective cation channel, and TDCA (taurodeoxycholic acid), an ..
  2. ncbi Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis
    Andrea Engler
    Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, Gloriastrasse 25, Zurich, Switzerland
    Biochem Biophys Res Commun 359:884-8. 2007
    The transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel, which is mainly expressed by nociceptive neurons in dorsal root and trigeminal ganglia...
  3. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons...
  4. ncbi A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
    ..The cloned capsaicin receptor, also known as the vanilloid receptor subtype 1 (VR1), is a heat-gated ion channel that has been proposed to mediate responses of small-diameter ..
  5. pmc Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
    E Mezey
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Basic Neuroscience Program, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3655-60. 2000
    The cloned vanilloid receptor VR1 has attracted recent attention as a molecular integrator of painful stimuli on primary sensory neurons. The existence of vanilloid-sensitive neurons in the brain is, however, controversial...
  6. ncbi Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
    P Hayes
    Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK
    Pain 88:205-15. 2000
    ..Mammalian cells transfected with human VR1 respond to capsaicin with an increase in intracellular calcium...
  7. ncbi Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1
    Z Olah
    Neuronal Gene Expression Unit, Pain and Neurosensory Mechanisms Branch, NIDCR, the Laboratory of Cellular Carcinogenesis and Tumor Promotion, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:11021-30. 2001
    ..cytotoxicity and the specific deletion of nociceptive neurons expressing the wild-type vanilloid receptor (VR1) were investigated...
  8. ncbi Analysis of the native quaternary structure of vanilloid receptor 1
    N Kedei
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:28613-9. 2001
    b>Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat. In the present study, we have analyzed the oligomeric state of VR1...
  9. ncbi Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
    Mitsuko Numazaki
    Department of Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    J Biol Chem 277:13375-8. 2002
    The capsaicin receptor, VR1, is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli...
  10. ncbi TRPV3 is a temperature-sensitive vanilloid receptor-like protein
    G D Smith
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK
    Nature 418:186-90. 2002
    Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin...
  11. ncbi cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 35:721-31. 2002
    The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli...
  12. ncbi Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes
    Michael D Southall
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 304:217-22. 2003
    ..The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation...
  13. pmc Structural determinant of TRPV1 desensitization interacts with calmodulin
    Mitsuko Numazaki
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Proc Natl Acad Sci U S A 100:8002-6. 2003
    The capsaicin receptor, TRPV1 (VR1), is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli...
  14. ncbi A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents
    Durga Prasanna Mohapatra
    Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Mol Cell Neurosci 23:314-24. 2003
    The Vanilloid Receptor TRPV1 is a non-selective cation channel with a high relative Ca(2+) permeability. TRPV1 exhibits slow desensitization, a potential mechanism regulating adaptation of peripheral sensory neurons to noxious stimuli...
  15. ncbi Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    Durga P Mohapatra
    Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 278:50080-90. 2003
    ..This sensitization is mediated by the cAMP-dependent protein kinase (PKA) signal pathway. The capsaicin receptor TRPV1, a non-selective cation channel of sensory neurons involved in the sensation of inflammatory pain, is ..
  16. pmc Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12480-5. 2003
    Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin...
  17. ncbi Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding
    Jooyoung Jung
    Sensory Research Center, Creative Research Initiatives, Seoul National University, College of Pharmacy, Kwanak gu, Shinlim 9 dong, Seoul 151 742, Korea
    J Biol Chem 279:7048-54. 2004
    Vanilloid receptor 1 (VR1), a capsaicin receptor, is known to play a major role in mediating inflammatory thermal nociception...
  18. ncbi Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
    Sonja Ständer
    Department of Dermatology, University of Munster, Muenster, Germany
    Exp Dermatol 13:129-39. 2004
    The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo...
  19. ncbi Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity
    Cruz Morenilla-Palao
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Avenida del Ferrocarril s n, 03202 Elche Alicante, Spain
    J Biol Chem 279:25665-72. 2004
    The vanilloid receptor-1 (TRPV1) plays a key role in the perception of peripheral thermal and inflammatory pain. TRPV1 expression and channel activity are notably up-regulated by proalgesic agents...
  20. ncbi Identification of a tetramerization domain in the C terminus of the vanilloid receptor
    Nuria García-Sanz
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, 03202 Alicante, Spain
    J Neurosci 24:5307-14. 2004
    TRPV1 (transient receptor potential vanilloid receptor subtype 1) is a member of the TRP channel family gated by vanilloids, protons, and heat...
  21. ncbi Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase
    Durga Prasanna Mohapatra
    Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 280:13424-32. 2005
    The vanilloid receptor TRPV1 is a polymodal nonselective cation channel of nociceptive sensory neurons involved in the perception of inflammatory pain...
  22. ncbi Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder
    Massimo Lazzeri
    Department of Urology, Ospedale Santa Chiara Firenze, Firenze, Italy
    Eur Urol 48:691-8. 2005
    To investigate possible changes in the expression of the transient receptor potential vanilloid type 1 (TRPV1) from normal urothelium to transitional cell carcinoma (TCC) of human bladder.
  23. ncbi Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists
    Pouya Movahed
    Department of Laboratory Medicine Lund University, SE 22185 Lund, Sweden
    J Biol Chem 280:38496-504. 2005
    ..This study shows that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV(1) and thus may play a role as endogenous TRPV(1) modulators...
  24. ncbi Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex
    Anastasia Liapi
    Biology Department, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 22:825-34. 2005
    The capsaicin receptor TRPV1, a member of the transient receptor potential (TRP) family of calcium-selective ion channels, responds to noxious stimuli and is predominantly expressed in nociceptive neurons...
  25. pmc NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 24:4211-23. 2005
    ..to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1. Several different mechanisms for sensitization of TRPV1 have been proposed...
  26. ncbi Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood
    Cassandra Im Saunders
    School of Human Life Sciences, University of Tasmania, Launceston, 7250 Tasmania, Australia
    Mol Immunol 44:1429-35. 2007
    The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activated TRPV2...
  27. pmc Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
    Alexander T Stein
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA
    J Gen Physiol 128:509-22. 2006
    Sensitization of the pain-transducing ion channel TRPV1 underlies thermal hyperalgesia by proalgesic agents such as nerve growth factor (NGF)...
  28. ncbi Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling
    Fan Zhang
    Biological Sciences, The State University of New York, College of Optometry, New York, New York 10036, USA
    J Cell Physiol 213:730-9. 2007
    In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge...
  29. pmc Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    Paul Facer
    Peripheral Neuropathy Unit, Imperial College, Hammersmith Hospital, London, UK
    BMC Neurol 7:11. 2007
    ..We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG...
  30. ncbi Dual regulation of TRPV1 by phosphoinositides
    Viktor Lukacs
    Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Neurosci 27:7070-80. 2007
    ..There are conflicting reports on the effect of PtdIns(4,5)P2 on transient receptor potential vanilloid 1 (TRPV1) channels...
  31. ncbi Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
    Alexandre A Steiner
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital, Phoenix, Arizona 85013, USA
    J Neurosci 27:7459-68. 2007
    ..We synthesized a new TRPV1 antagonist, AMG0347 [(E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)..
  32. pmc Determinants of molecular specificity in phosphoinositide regulation. Phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is the endogenous lipid regulating TRPV1
    Rebecca M Klein
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    J Biol Chem 283:26208-16. 2008
    ..b>TRPV1 is a good example; although phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P(2)) can potently regulate its ..
  33. doi Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge CB21PD, UK
    Neuron 59:450-61. 2008
    ..Here, we show that modulation of the sensitivity of the heat-activated ion channel TRPV1 by the protein kinases PKA and PKC and by the phosphatase calcineurin depends on the formation of a signaling ..
  34. doi Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma
    Gabriella Czifra
    Department of Physiology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    J Cancer Res Clin Oncol 135:507-14. 2009
    Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular ..
  35. pmc Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 23:360-70. 2008
    ..Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, ..
  36. pmc Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, Minnesota, USA
    Cancer Res 69:905-13. 2009
    Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief...
  37. pmc The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
    Andrej A Romanovsky
    Systemic Inflammation Laboratory, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Pharmacol Rev 61:228-61. 2009
    The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel as pain therapeutics has revealed that these compounds cause hyperthermia in humans...
  38. pmc The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels
    Sonia Gallego-Sandín
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, C Sanz y Fores s n, 47003 Valladolid, Spain
    J Biol Chem 284:32591-601. 2009
    Transient receptor potential vanilloid type 1 (TRPV1) is a plasma membrane Ca(2+) channel involved in transduction of painful stimuli...
  39. doi Expression of transient receptor potential vanilloid-1 (TRPV1) in urothelial cancers of human bladder: relation to clinicopathological and molecular parameters
    Cristina Kalogris
    School of Pharmacy, University of Camerino, Camerino MC, Italy
    Histopathology 57:744-52. 2010
    To evaluate the expression of transient receptor potential vanilloid type-1 channel protein (TRPV1) in normal and neoplastic urothelial tissues and to correlate TRPV1 expression with clinicopathological parameters and disease-specific ..
  40. pmc The biophysical and molecular basis of TRPV1 proton gating
    Eduardo Aneiros
    Department of Pain Biology, Pfizer Global Research and Development, Sandwich Laboratories, Kent, UK
    EMBO J 30:994-1002. 2011
    The capsaicin receptor TRPV1, a member of the transient receptor potential family of non-selective cation channels is a polymodal nociceptor. Noxious thermal stimuli, protons, and the alkaloid irritant capsaicin open the channel...
  41. doi Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1
    Li Chieh Ching
    Department of Physiology, National Yang Ming University, Taipei, Taiwan
    Cardiovasc Res 91:492-501. 2011
    We investigated the molecular mechanism underlying the role of transient receptor potential vanilloid type 1 (TRPV1), a Ca(2+)-permeable non-selective cation channel, in the activation of endothelial nitric oxide (NO) synthase (eNOS) in ..
  42. pmc Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel
    Giovanni Picazo-Juárez
    Departamento de Neurodesarrollo y Fisiología, Division Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, D F 04510, Mexico
    J Biol Chem 286:24966-76. 2011
    The TRPV1 ion channel serves as an integrator of noxious stimuli with its activation linked to pain and neurogenic inflammation. Cholesterol, a major component of cell membranes, modifies the function of several types of ion channels...
  43. doi Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia
    Michael J M Fischer
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Neurosci 33:7407-14. 2013
    Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel that plays a key role in enhanced pain sensation after inflammation, but directly blocking TRPV1 causes hyperthermia and decreased sensitivity to ..
  44. pmc Regulation of TRPV1 ion channel by phosphoinositide (4,5)-bisphosphate: the role of membrane asymmetry
    Eric N Senning
    From the Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195 7290 and
    J Biol Chem 289:10999-1006. 2014
    ..that the signaling lipid phosphoinositide 4,5-bisphosphate (PI(4,5)P2) has opposite effects on the function of TRPV1 ion channels depending on which leaflet of the cell membrane it resides in...
  45. ncbi The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants
    Q Xue
    Department of Anesthesia and Perioperative Care, The University of California, San Francisco, California, 94143 0648, USA
    Genomics 76:14-20. 2001
    Vanilloid receptor subtype-1 (VR1) is a nonselective cation channel that is expressed in sensory neurons and is activated by multiple noxious stimuli...
  46. ncbi Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency
    C L H Chan
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Lancet 361:385-91. 2003
    ..We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre ..
  47. ncbi Role and regulation of TRP channels in neutrophil granulocytes
    Inka Heiner
    Institut fur Physiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Cell Calcium 33:533-40. 2003
    ..which mRNA can be demonstrated in neutrophil granulocytes with RT-PCR include TRPC6 (as only "short" TRP), TRPM2, TRPV1, TRPV2, TRPV5 and TRPV6...
  48. ncbi Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells
    N Agopyan
    Department of Anesthesiology, Duke University Medical Center, Room 435, DUMC 3209, Research Drive, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 192:21-35. 2003
    ..currents and increases in intracellular calcium ([Ca2+]i) in capsaicin- and acid-sensitive sensory neurons and in TRPV1-expressing HEK 293 cells...
  49. ncbi Molecular determinants of vanilloid sensitivity in TRPV1
    Narender R Gavva
    Department of Neuroscience, Amgen Inc, MS 29 2 B, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    J Biol Chem 279:20283-95. 2004
    Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by ..
  50. pmc A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control
    Eniko Bodo
    Department of Physiology, University of Debrecen, MHSC, 4012 Debrecen, Nagyerdei krt 98, Hungary
    Am J Pathol 166:985-98. 2005
    The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers...
  51. ncbi TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
    Melissa H Vos
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurochem 99:1088-102. 2006
    ..The human TRPV1 splice variant, TRPV1b, lacking exon 7, was cloned from human dorsal root ganglia (DRG) RNA...
  52. ncbi Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity
    Li Li Zhang
    Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China
    Circ Res 100:1063-70. 2007
    We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis...
  53. pmc The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis
    Rodger A Liddle
    Department of Medicine, Box 3913, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1772:869-78. 2007
    ..Recent studies indicate that primary sensory neurons of the pancreas express transient receptor potential V1 (TRPV1) channels whose activation induces pancreatic inflammation...
  54. ncbi Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene
    Hongshi Xu
    Oregon Health and Science University, 3314 S W US Veterans Hospital Rd, Portland, OR 97201, USA
    Am J Physiol Renal Physiol 293:F1865-76. 2007
    ..The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1. TRPV1 mediates aspects of nociception and neurogenic inflammation; however, new roles are emerging in sensation ..
  55. pmc Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma
    Gerard Cantero-Recasens
    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Biol Chem 285:27532-5. 2010
    ..b>TRPV1 expression and activity appear to be altered under pathophysiological conditions such as chronic cough and airway ..
  56. pmc C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:40601-7. 2011
    ..specific cysteine residue(s) by oxidative stress robustly potentiates transient receptor potential vanilloid 1 (TRPV1) and sensitizes nociception...
  57. ncbi Versatile regulation of cytosolic Ca2+ by vanilloid receptor I in rat dorsal root ganglion neurons
    Min Liu
    Department of Neuroscience, St Bartholomew s, Mile End Road, London EC1 4NS, United Kingdom
    J Biol Chem 278:5462-72. 2003
    ..by the phospholipase C inhibitor xestospongins, indicating that Ca(2+) mobilization was dependent on capsaicin receptor binding and was not due to intracellular inositol-1,4,5-trisphosphate generation...
  58. pmc Ruthenium red, but not capsazepine reduces plasma extravasation by cigarette smoke in rat airways
    P Geppetti
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130
    Br J Pharmacol 108:646-50. 1993
    ..contained in or agent(s) produced by cigarette smoke in the airways share partially a common pathway with capsaicin to activate peptide release from capsaicin-sensitive sensory nerves, but do not bind to the putative 'capsaicin receptor'.
  59. ncbi Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum
    Makoto Kadowaki
    Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Auton Neurosci 116:11-8. 2004
    ..rat intestine and the origin of nerve fibers expressing transient receptor potential vanilloid 1 (TRPV1: capsaicin receptor) in the rat jejunum by combination of functional and immunohistochemical experiments...
  60. pmc Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin
    Qing Lin
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 3:30. 2007
    Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs)...
  61. ncbi Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
    Silvia Amadesi
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Neurosci 24:4300-12. 2004
    ..We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia...
  62. ncbi Antiallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates
    Eduardo R Butelman
    The Rockefeller University, Box 171, 1230 York Ave, New York, NY 10021, USA
    J Pharmacol Exp Ther 311:155-63. 2004
    Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)]...
  63. doi N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
    Pharmacol Res 63:294-9. 2011
    ..e. the transient receptor potential of vanilloid type-1 (TRPV1) channel, and, either directly or indirectly, cannabinoid receptors of type-1...
  64. ncbi Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus
    Ammar Boudaka
    Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Eur J Pharmacol 556:157-65. 2007
    Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory ..
  65. ncbi Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1
    Narender R Gavva
    Department of Neuroscience, Amgen Inc, MS 29 2 B, One Amgen Center Dr, Thousand Oaks, California 91320 1799, USA
    Mol Pharmacol 68:1524-33. 2005
    Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat...
  66. ncbi Vanilloid receptor ligands: hopes and realities for the future
    A Szallasi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Drugs Aging 18:561-73. 2001
    ..These neurons carry receptors that bind capsaicin, recently identified as the vanilloid VR1 receptor...
  67. ncbi Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat
    Robin D Lewinter
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 470:400-8. 2004
    ..TRPV2) is a member of the TRPV family of proteins and is a homolog of the capsaicin/vanilloid receptor (VR1, or TRPV1). Although VRL-1 does not bind capsaicin, like VR1 it is activated by noxious heat (>52 degrees C)...
  68. ncbi The activation of transient receptor potential vanilloid receptor subtype 1 by capsaicin without extracellular Ca2+ is involved in the mechanism of distinct substance P release in cultured rat dorsal root ganglion neurons
    He Bin Tang
    Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:325-32. 2008
    ..can induce SP release in the absence of extracellular Ca2+ by activating transient receptor potential vanilloid receptor subtype 1 (TRPV1)...
  69. pmc Acidification of rat TRPV1 alters the kinetics of capsaicin responses
    Torben R Neelands
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R04PM, AP9A, Abbott Park, IL 60064 6123, USA
    Mol Pain 1:28. 2005
    b>TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C...
  70. pmc 17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons
    Shenghong Xu
    Pain Management Research Institute, The University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Endocrinology 149:5540-8. 2008
    ..which increases phosphorylation of the nociceptor transducer transient receptor potential vanilloid receptor 1 (TRPV1)...
  71. ncbi Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurophysiol 90:2702-10. 2003
    It is well established that the vanilloid receptor, VR1, is an important peripheral mediator of nociception...
  72. ncbi TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice
    Lihong Wang
    Department of Cardiovascular Sciences, First Affiliated Hospital, College of Medicine, Zhejiang University, China
    Circulation 112:3617-23. 2005
    Although pharmacological studies suggest that the transient receptor potential vanilloid type 1 (TRPV1) channels expressed in sensory nerve fibers innervating the heart may exert a cardioprotective effect, definitive evidence supporting ..
  73. pmc Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors
    Beihua Zhong
    Department of Medicine, B316 Clinical Center, Michigan State University, East Lansing, Michigan 48824, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1681-90. 2009
    Activation of the protease-activated receptor 2 (PAR2) or the transient receptor potential vanilloid type 1 (TRPV1) channels expressed in cardiac sensory afferents containing calcitonin gene-related peptide (CGRP) and/or substance P (SP) ..
  74. ncbi Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde
    Li Juan Tian
    Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, China
    Sheng Li Xue Bao 61:404-16. 2009
    ..primary nociceptor cells were evaluated in vitro and the roles of the vanilloid receptor TRPV1 in FA-produced activation of primary nociceptors were also examined at both cellular and behavioral levels...
  75. ncbi Detection of NaCl and KCl in TRPV1 knockout mice
    Collin Ruiz
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Chem Senses 31:813-20. 2006
    ..and foliate taste buds, was recently reported to involve a variant of the nonselective cation channel TRPV1. We performed 2-bottle preference and threshold experiments with TRPV1 knockout mice and wild-type (C57BL/6J) ..
  76. ncbi The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop
    R J Dekker
    Department of Biochemistry Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands
    J Mol Biol 293:613-27. 1999
    Substitution of the native variable region-1 (VR1/37-loop) of thrombin by the corresponding VR1 of tissue-type plasminogen activator (thrombin-VR1(tPA)) increases the rate of inhibition by plasminogen activator inhibitor type 1 (PAI-1) ..
  77. doi Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
    Michael St Pierre
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Exp Brain Res 196:31-44. 2009
    The capsaicin receptor TRPV1 is a polymodal sensory transducer molecule in the pain pathway. TRPV1 integrates noxious heat, tissue acidosis and chemical stimuli which are all known to cause pain...
  78. doi Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors
    M Camprubí-Robles
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Av de la Universidad s n, 03202 Elche, Alicante, Spain
    FASEB J 23:3722-33. 2009
    Potentiation of the pain-integrator ion channel transient receptor potential vanilloid type 1 (TRPV1) underlies thermal hyperalgesia mediated by a variety of proinflammatory factors...
  79. ncbi TRPV1 antagonists as potential antitussive agents
    Robbie L McLeod
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Lung 186:S59-65. 2008
    ..Afferent pulmonary nerves are endowed with a multitude of potential receptor targets, including TRPV1, that could act to attenuate cough. The evidence linking TRPV1 to cough is convincing...
  80. doi TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea
    Tatjana I Kichko
    Department of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Neurosci 29:1896-904. 2009
    ..from inflammatory hypersensitivity of tracheobronchial nerve endings, most of which express the polymodal capsaicin receptor-channel transient receptor potential vanilloid (TRPV) type 1 and the secretory neuropeptide calcitonin gene-..
  81. ncbi Somatostatin modulates the transient receptor potential vanilloid 1 (TRPV1) ion channel
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 110:616-27. 2004
    ..SSTR modulation of nociceptors is regulation of the transient receptor potential vanilloid 1 ion channel (TRPV1, formerly the VR1 receptor)...
  82. pmc Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel
    Zoltan Olah
    Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary Acheuron Hungary Ltd, Szeged, Hungary Acheuron Pharmaceuticals Inc, San Diego, California, United States of America
    PLoS ONE 2:e545. 2007
    ..were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry...
  83. pmc TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat
    Jeffrey J Lawson
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Pain 9:298-308. 2008
    ..was used to determine the response characteristics of cutaneous sensory neurons staining positively for TRPV1 or TRPV2...
  84. pmc ThermoTRP Channels in Nociceptors: Taking a Lead from Capsaicin Receptor TRPV1
    Sravan Mandadi
    Hotchkiss Brain Institute, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Curr Neuropharmacol 6:21-38. 2008
    ..Capsaicin, a pungent chemical in hot peppers, has assisted in the cloning of the first thermoTRP, TRPV1. This discovery initiated the search for other receptors encoding the response to a wide range of temperatures ..
  85. ncbi Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa
    Q Thai Dinh
    Department of Medicine, Charite, Humboldt University, Berlin, Germany
    Neuropeptides 37:245-50. 2003
    ..nerve endings to various stimuli is considered to be induced by activation of the capsaicin (vanilloid) receptor (VR1)...
  86. ncbi Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor
    Qing Xue
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0427, USA
    J Neurochem 101:212-22. 2007
    The capsaicin receptor, also known as 'transient receptor potential vanilloid receptor subtype 1' (TRPV1, VR1), is an ion channel subunit expressed in primary afferent nociceptors, which plays a critical role in pain transduction and ..
  87. pmc Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C
    Tim D Plant
    Institut fur Pharmakologie und Toxikologie, FB Medizin, Philipps Universitat Marburg, Karl von Frisch Str, 1, 35032 Marburg, Germany
    Mol Pain 3:35. 2007
    ..The cellular mechanisms of this ET-1-mediated effect are only poorly understood. TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular ..
  88. ncbi Differential development of TRPV1-expressing sensory nerves in peripheral organs
    Kengo Funakoshi
    Department of Neuroanatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama, 236 0004, Japan
    Cell Tissue Res 323:27-41. 2006
    In mouse ontogeny, neurons immunoreactive for transient receptor potential vanilloid receptor 1 (TRPV1) were observed primarily in the dorsal root ganglia (DRG) at embryonic day 13 (E13)...
  89. doi Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?
    H Lindegren
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    Toxicol In Vitro 23:1472-6. 2009
    The transient receptor potential vanilloid type 1 (TRPV1) has been reported as one of the key components in the pain pathway...
  90. ncbi The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
    K Zimmermann
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, D 91054 Erlangen, Germany
    Neuroscience 135:1277-84. 2005
    b>TRPV1 gene disruption results in a loss of capsaicin and proton responsiveness, but has minimal effects on heat-induced nocifensive behavior, suggesting that sensory transduction of heat is independent of TRPV1...
  91. ncbi Changes in vanilloid receptor 1 (TRPV1) expression following lingual nerve injury
    James E Biggs
    Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, South Yorkshire S10 2TA, UK
    Eur J Pain 11:192-201. 2007
    We have investigated a possible role for vanilloid receptor 1 (TRPV1), a transducer of noxious stimuli, in the development of neuropathic pain following injury to a peripheral branch of the trigeminal nerve...
  92. ncbi Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases, National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 11:262-71. 2006
    We describe the expression of the capsaicin receptor (TRPV1) in human peripheral nervous system (PNS) and its changes in sural nerve and skin nerve fibers of patients with painful neuropathy...
  93. doi Investigation of sensory neurogenic components in a bleomycin-induced scleroderma model using transient receptor potential vanilloid 1 receptor- and calcitonin gene-related peptide-knockout mice
    Arpád Szabó
    University of Pecs, Pecs, Hungary
    Arthritis Rheum 58:292-301. 2008
    ..with their classic afferent function (nociception), capsaicin-sensitive transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve terminals exert local and systemic efferent activities...
  94. doi Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids
    Alline Cristina Campos
    Department of Pharmacology, School of Medicine of Ribeirão Preto Campus USP, 14049 900, Ribeirao Preto, SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 33:1517-21. 2009
    ..The reasons for these curves are still unclear, but since these drugs can also activate TRPV1 receptors and increase glutamate release, we hypothesized that, at high doses, cannabidiol and WIN 55,212-2, a CB1 ..
  95. doi TRPV1 receptors are involved in protein nitration and Müller cell reaction in the acutely axotomized rat retina
    Mauro Leonelli
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP 05508 900, Brazil
    Exp Eye Res 91:755-68. 2010
    We report here the protein expression of TRPV1 receptor in axotomized rat retinas and its possible participation in mechanisms involved in retinal ganglion cell (RGC) death...
  96. doi Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis
    Joelle M J Romac
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Pancreas 36:394-401. 2008
    Transient receptor potential subtype vanilloid 1 (TRPV1) is an ion channel that is primarily expressed by primary sensory neurons where it mediates pain and heat sensation and participates in neurogenic inflammation...
  97. pmc The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
    Michael J M Fischer
    Institute of Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen 91054, Germany
    J Biol Chem 285:34781-92. 2010
    ..concentrations of propofol activated the recombinant transient receptor potential (TRP) receptors TRPA1 and TRPV1 heterologously expressed in HEK293t cells...
  98. ncbi Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion
    Lei Pei
    Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neurosci Bull 23:92-100. 2007
    To investigate the involvement of transient receptor potential vanilloid receptor 1 (TRPV1) in the facial inflammatory pain in relation to thermal hyperalgesia and cold pain sensation.
  99. ncbi Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Am J Physiol Lung Cell Mol Physiol 292:L1173-81. 2007
    ..are densely innervated by capsaicin-sensitive sensory neurons expressing transient receptor potential vanilloid 1 (TRPV1) receptors/ion channels, which play an important regulatory role in inflammatory processes via the release of ..
  100. ncbi Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia
    Yoshihito Kanai
    Discovery Biology Research, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Inc, 5 2 Taketoyo, Aichi, 470 2393, Japan
    J Pharm Pharmacol 59:733-8. 2007
    Transient receptor potential vanilloid 1 (TRPV1) antagonists are known to attenuate two typical symptoms of inflammatory hyperalgesia: thermal and mechanical...
  101. doi Functional study on TRPV1-mediated signalling in the mouse small intestine: involvement of tachykinin receptors
    J G de Man
    Division of Gastroenterology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Neurogastroenterol Motil 20:546-56. 2008
    ..motility and secretion and is postulated to involve the transient receptor potential of the vanilloid type 1 (TRPV1)...

Research Grants72

  1. KATHRYN MARIE ALBERS; Fiscal Year: 2014
    ..Analysis of sensory ganglia of ART-OE mice showed enhanced expression of TRPV1 and TRPA1 suggesting the activity of these channel receptors underlie at least some of the Artn-induced ..
  2. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..nociceptors by co-applying a permanently charged derivative of lidocaine (QX- 314) with capsaicin, an agonist for TRPV1 channels...
  3. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..years our research efforts have focused on the roles played by purinergic P2X receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  4. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..years our research efforts have focused on the roles played by purinergic P2X receptors, capsaicin receptors (TRPV1) and acid sensing ion channels in evoking abnormal SNA responses to muscle contraction in HF...
  5. DUSTIN PEPPER GREEN; Fiscal Year: 2014
    ..of the family of transient receptor potential (TRP) ligand-gated ion channels is the TRP vanilloid subfamily 1 (TRPV1) ion channel, and is expressed on a major subpopulation of nociceptive neurons...
  6. CAPSAICIN RECEPTOR SUBTYPES IN PAIN TRANSDUCTION
    Mark A Schumacher; Fiscal Year: 2012
    ..TRPV1, also known as the capsaicin receptor, has been at the forefront of research focused on the development of new strategies to treat chronic painful ..
  7. Serotonin Modulation of Trigeminal Nociceptors
    DAYNA RUTH LOYD; Fiscal Year: 2010
    ..The transient receptor potential V1 channel (TRPV1), gaited by heat and capsaicin (the pungent ingredient in chili peppers), is highly expressed on trigeminal ..
  8. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
    ..Transient receptor potential vanilloid 1 (TRPV1) is an important non-selective cation channel and receptor in this process...
  9. MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Transient Receptor Potential Vanilloid Type 1 Receptors (TRPV1) contribute to detection of noxious heat (>420C) and tissue damage by spinal primary afferent nociceptors...
  10. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..this in mind, we have recently discovered a novel family of peptide toxins from tarantula that activate the capsaicin receptor, TRPV1, to produce inflammatory pain (presumably as part of the spider's defensive strategy to ward off ..
  11. Allan I Basbaum; Fiscal Year: 2015
    ..The MOR predominates in the peptidergic nociceptors, which express the capsaicin and heat responsive channel, TRPV1, and regulates heat pain. The present proposal builds upon these observations...
  12. TRPV1 regulation by B-arrestins
    ELAINE DARCEY POR; Fiscal Year: 2012
    ..The first TRP member identified, TRPV1 (Transient Receptor Potential Vanilloid 1), has been the most extensively studied with regards to pain...
  13. Mary G Garry; Fiscal Year: 2014
    ..First, we have determined that the TRPv1 receptor (previously known as the capsaicin receptor) mediates the EPR in the rat...
  14. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..protein kinase C epsilon and D in PAR2-induced sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), a major mediator of inflammatory and thermal pain, will be determined using isolated cells and intact animals...
  15. Hongzhen Hu; Fiscal Year: 2016
    ..desensitized TRPA1, suggesting that zinc can inhibit TRPA1 by inducing receptor desensitization like capsaicin to TRPV1. We also show that zinc suppressed TRPV1 function both in vitro and in vivo and genetic ablation of TRPA1 ..
  16. Tibor Rohacs; Fiscal Year: 2016
    ..b>TRPV1 channels are activated by heat, capsaicin, low pH and a plethora of other pain producing stimuli...
  17. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2009
    ..signal nonevoked, guarding pain behavior and that this ongoing activity is due to NGF-induced sensitization of TRPV1 to heat and acid pH...
  18. Development of Anti-OLAM Aptamers as Novel Analgesics
    John G Bruno; Fiscal Year: 2012
    ..b>TRPV1, a prominent member of the transient receptor potential (TRP) family of ligand-gated ion channel, detects noxious ..
  19. Rodger A Liddle; Fiscal Year: 2016
    ..Primary sensory neurons are capsaicin-sensitive and express the capsaicin receptor [known as transient receptor potential vanilloid 1 (TRPV1)]...
  20. David Julius; Fiscal Year: 2016
    ..primarily on understanding the structure and biophysical properties of the capsaicin- and heat-activated receptor, TRPV1 - perhaps the best-characterized member of the mammalian TRP channel family...
  21. JAMES HENRY PETERS; Fiscal Year: 2016
    ..express the calcium permeable non-selective ion channel 'transient receptor potential vanilloid type 1'(TRPV1)...
  22. Structure and Function of TRPV Ion Channels
    Rachelle Gaudet; Fiscal Year: 2012
    ..We have recently identified a physiologically important multi-ligand binding site within the TRPV1-ARD that modulates TRPV1 channel sensitivity...
  23. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..5 immunohistochemistry) and markers of nociception (via calcitonin gene related peptide and the vanilloid receptor TRPV1);(c) to examine the immunological profile of vulvar tissue following chronic inflammation to reveal potential pain ..
  24. POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
    Kathleen C Light; Fiscal Year: 2013
    ..of ion channel receptors (including Acid Sensing Ion Channel-3 or ASIC3, ATP-sensing Purinergic 2X or P2X, and TRPV1 or capsaicin receptors) working together can detect increased metabolic by-products of work in muscle (ATP, ..
  25. Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury
    ERIC RICHARD GROSS; Fiscal Year: 2012
    ..I am interested in examining the role of the transient receptor vanilliod channel (TRPV1) in myocardial salvage from ischemia- reperfusion injury...
  26. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2012
    ..in sensory fibers that are also sensitive to capsaicin, the plant-derived irritant that activates the capsaicin receptor, TRPV1. These sensory fibers, the C-fibers, are known to mediate irritant effects and inflammatory pain...
  27. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..It will also address the effects of RTX treatment on the expression of TRPV1, CGRP and SP in thoracolumbar and lumbosacral DRG neurons...
  28. Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..Analyses under Specific Aims 1-3 will determine if common polymorphisms (alternative forms of a gene) for the TRPV1 receptor predict differential response to the burning sensations from these irritants...
  29. William N Zagotta; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): TRPV1 ion channels are multimodal receptors that can be activated by heat, high [H+]o, voltage, arachidonic acid metabolites, capsaicin (the pungent extract of hot chili peppers), and the signaling ..
  30. Structure and Function of the Transient Receptor Potential Vanilloid-1 Channel
    LUCIANN L CUENCA; Fiscal Year: 2013
    ..Transient Receptor Potential Vanilloid-1 (TRPV1), a polymodal non-selective cation channel, has emerged as a key player in pain perception...
  31. MECHANISMS OF SYNAPTIC TRANSMISSION IN THE RETINA
    Scott Nawy; Fiscal Year: 2013
    ..suggest that it is a member of the TRP channel family in particular, and the vanilloid subgroup of the TRP family, TRPV1 in particular...
  32. Jie Zheng; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The heat sensor TRPV1 channel is a polymodal receptor that plays a key role in mediating neuronal pain caused by various noxious stimuli...
  33. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  34. RNA Aptamers Selective for TPRV Channels
    ROGER O NEIL; Fiscal Year: 2009
    ..Two isoforms of the vanilloid receptor subfamily of TRP channels, TRPV1 (the capsaicin receptor) and TRPV4 (an osmoreceptor), display polymodal gating behavior with sensitivity to numerous noxious stimuli...
  35. Cochlear Type II Afferents and Nociception in the Inner*
    Jaime Garcia Anoveros; Fiscal Year: 2004
    ..channels (the acid-sensitive and presumed mechanosensitive BNaC1alpha and the acid and heat sensitive capsaicin receptor) known to participate in mechanosensation and nociception by somatosensory neurons...
  36. Characterization of Endogenous Capsaicin-Like Lipids
    Constance Chu; Fiscal Year: 2004
    ..may function as endovanilloids involved in pain modulation through activation of the vanilloid type 1 receptor (VR1) in the periphery and/or the brain...
  37. Role of TRPV1 in Cancer Pain
    MEEGHAN LAUTNER; Fiscal Year: 2009
    ..plan will test the hypothesis that tumor cells release a soluble factor that activates or sensitizes the capsaicin receptor TRPV1...
  38. John W Wiley; Fiscal Year: 2016
    ..The endovanilloid transient receptor potential (TRP) pathway plays a pivotal role in pain transmission and the TRPV1 receptor is known to be regulated by endocannabinoids (CB) acting on CB1 receptors which inhibit TRPV1 function...
  39. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    ..CB1 receptor gene expression which, in turn, inhibits the function of pro-nociceptive endovanilloid TRPV1 receptors. Chronic stress down-regulates CB1 expression and up-regulates TRPV1 expression...
  40. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..of our ongoing project, NIH Grant CA091007, in which we are examining the contribution of peripheral P2X and TRPV1 receptors in cancer pain and nociceptor sensitization Results from these studies will provide new information on ..
  41. Analgesics Targeting TRPA1 for Treatment of Chronic Pain
    JEFF MARK HERZ; Fiscal Year: 2011
    ..AIM 3 will be to define the pharmacological selectivity using a panel of related TRP channels using TRPV1, TRPV3 and TRPM8: AIM 4 wil be to pharmacological Characterize Activity Using Dorsal Root Ganglion (DRG) cells: ..
  42. Control of Arthritic Pain by Inhibition of TRPA1 Activity
    JEFF MARK HERZ; Fiscal Year: 2013
    ..antagonists will be defined among members of the TRP superfamily using a panel of related TRP channels, including TRPV1, TRPV3, TRPM8 and several TRPC members...
  43. Characterization and Plasticity of Visceral Nociceptors
    Brian M Davis; Fiscal Year: 2012
    ..found that visceral organs (colon, bladder, pancreas and stomach) are densely innervated by afferents expressing TRPV1 and/or TRPA1, two channels that have been shown to be required for development of inflammatory hyperalgesia...
  44. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..in both somatic and visceral sensation, express key ion channels that are implicated in somatic and visceral pain (TrpV1, TrpA1), and GFLs can produce analgesia and hyperalgesia...
  45. Sharona E Gordon; Fiscal Year: 2016
    ..We have chosen the Ca2+-permeable channel TRPV1 as our model both because its properties make it especially suitable and because of its importance in transducing ..
  46. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2013
    ..III are localized on primary sensory neurons and are co-localized with TRP receptors that participate in heat (TRPV1), mechanical (TRPV4), and cold (TRPA1) transduction (aim 1)...
  47. CHERYL LOUISE STUCKY; Fiscal Year: 2016
    ..2) Determine the contribution of the Transient Receptor Potential (TRP) Ion Channels TRPA1 and TRPV1 to both the behavioral hypersensitivity and the sensitization of primary afferent fibers in sickle cell disease...
  48. Feng Qin; Fiscal Year: 2016
    ..We will focus on the vanilloid receptor TRPV1, a founding member of the thermal TRP subfamily...
  49. Endothelin mechanisms in metastic prostate cancer pain
    Gary Strichartz; Fiscal Year: 2009
    ..ET-1's actions during cutaneous injury/inflammation is closely linked to three other molecules/ receptors; TRPV1 (the receptor for hot peppers that is also activated by heat and by a H+), glutamate, and CGRP...
  50. Gary R Strichartz; Fiscal Year: 2014
    ..ET-1's actions during cutaneous injury/inflammation is closely linked to three other molecules/ receptors;TRPV1 (the receptor for hot peppers that is also activated by heat and by a H+), glutamate, and CGRP...
  51. NGF-Dependent Sensitization of Nociceptors by Opiates
    Frank Porreca; Fiscal Year: 2012
    ..p38 MAPK (pp38 MAPK) in TrkA-positive cells, (c) increase NGF-dependent and pp38 MAPK-dependent trafficking of the TRPV1 channel to the periphery, (d) upregulate CGRP and substance P (SP) expression in TrkA-positive cells in an NGF-..
  52. Kenneth M Hargreaves; Fiscal Year: 2014
    ..Both pharmacological and gene deletion studies have demonstrated a pivotal role for TRPV1 (transient receptor potential subtype V1) in inflammatory heat hyperalgesia and thermoregulation and this receptor ..
  53. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..We will analyze TRPV1 simultaneously as a comparison...
  54. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..transient receptor potential (Trp) family of liganded ion channels, which include the noxious heat/pepper receptor TrpV1, the mustard oil receptor TrpA1, and the cold/menthol receptor TrpM8...
  55. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..We propose that chemical activation of TRPA1 homomers, or TRPA1/TRPV1 heteromers on trigeminal neurons innervating the meninges results in release of calcitonin gene-related peptide (..
  56. Functional Interactions Between Peripheral P2X3 and TRP Channels
    JAMI LYNN SALOMAN; Fiscal Year: 2012
    ..b>TRPV1 and TRPA1 (TRPV1/A1) channels have also previously been implicated in the development of mechanical hyperalgesia ..
  57. JOSHUA EMRICK; Fiscal Year: 2016
    ..g., ion channels) serves to delineate nociceptor subgroups (e.g., TRPV1/heat, TRPM8/cold, and TRPA1/chemical irritants) (Basbaum, Bautista et al. 2009)...
  58. Yuriy M Usachev; Fiscal Year: 2014
    ..We hypothesize that C3a and C5a receptors are expressed and functionally coupled with TRPV1 in a subset of primary nociceptors;activation of these receptors sensitize nociceptors via protein kinase C-..
  59. Molecular and spatial mapping of bladder nociceptors during development and matur
    Adam Wallace; Fiscal Year: 2013
    ..The experiments will focus on nociceptive neurons, identified in a Trpv1 reporter mouse, to develop a deeper understanding of their structure and connections with the bladder, and their &..
  60. Glucocorticoids and endocannabinoids in vagal complex
    Bret N Smith; Fiscal Year: 2013
    ..fashion, activate both cannabinoid type 1 receptors (CB1R) and transient receptor potential vanilloid type 1 (TRPV1). In the DMV, activation of TRPV1 enhances neurotransmitter release, whereas CB1R tends to inhibit synapses...
  61. TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids
    THOMAS J MC INTOSH; Fiscal Year: 2012
    The Transient Receptor Potential Vanilloid 1 channel (TRPV1) is a key component of nociceptors and is also a mechanosensor in the urinary bladder and osmosensor in neurons...
  62. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..cannabinoid agonists alleviates LID via activation of CB1 cannabinoid receptors and concomitant desensitization of TRPV1 receptors through a phosphatase-operated mechanism...
  63. Allan I Basbaum; Fiscal Year: 2014
    ..The experiments outlined in Specific Aim 1 will continue these studies, focusing on the peptide, non- peptide and TRPV1 subsets of nociceptors...
  64. MOLECULAR MECHANISMS OF RECEPTOR AND CHANNEL FUNCTION
    David Julius; Fiscal Year: 2002
    ..The specific aims of the proposal are to: (i) isolate and characterize novel capsaicin receptor- related receptors from the mammalian nervous system; (ii) pinpoint domains of the capsaicin receptor that ..
  65. NERVE GROWTH FACTOR AND PAIN
    LORNE MENDELL; Fiscal Year: 2000
    ..Capsaicin can be viewed as a surrogate for noxious heat since the latter activates the capsaicin receptor VR1. It therefore follows that NGF may sensitize the response to noxious heat directly...
  66. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..For example, demonstration of vanilloid receptors (VR1) in urothelial cells sensitive to capsaicin and protons suggests that VRI in non-neuronal cells may have a role in ..
  67. MOLECULAR BASIS OF ACTION OF NOVEL SENSORY IRRITANTS
    Igor Mezine; Fiscal Year: 1999
    ..the pungent principals derived from the genus Capsicum, led to the discovery ad characterization of a capsaicin receptor mechanism in sensory neurons and afforded several molecular probes for studying the cellular and systemic ..
  68. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    b>TRPV1 is a cation channel that was originally cloned as the capsaicin (or "hot pepper") receptor...
  69. Agonist-evoked changes in TRPV ion channel selectivity
    Michael J Caterina; Fiscal Year: 2011
    The capsaicin receptor, TRPV1, is one of four cation channels of the transient receptor potential vanilloid (TRPV) subfamily that can be activated by warm or painfully hot temperatures...
  70. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..e., calcineurin);2) dephosphorylation of TRPV1;and 3) inhibition of TRPV1 activity in a fashion reversed by calcineurin antagonists...
  71. Mechanisms of Vanilloid Receptor-Induced Cell Death
    Christopher Reilly; Fiscal Year: 2005
    ..The hypothesis of this application is: the expression and activity of vanilIoid receptors (VR1, VR...
  72. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
    ..The research aims at elucidating the role of vanilloid receptor TRPV1 in the sensory nerves to the joints and in the pathophysiological mechanisms of chronic osteoarthritis...