TrkB

Summary

Gene Symbol: TrkB
Description: neurotrophic receptor tyrosine kinase 2
Alias: GP145-TrkB, TRKB, trk-B, BDNF/NT-3 growth factors receptor, BDNF-tropomyosine receptor kinase B, neurotrophic tyrosine kinase receptor type 2, tropomyosin-related kinase B, tyrosine kinase receptor B
Species: human

Top Publications

  1. doi Overexpression of TrkB promotes the progression of colon cancer
    Yingjiao Yu
    Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China
    APMIS 118:188-95. 2010
  2. ncbi Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
    A Nakagawara
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 25:538-46. 1995
  3. ncbi Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan
    T B Romanczyk
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Building 10 4 N312, MSC 1385, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 15:269-80. 2002
  4. ncbi Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    Sirith Douma
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Nature 430:1034-9. 2004
  5. ncbi Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:372-83. 2005
  6. pmc Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence
    K Xu
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 7:368-79. 2007
  7. ncbi Identification of brain-derived neurotrophic factor as a novel angiogenic protein in multiple myeloma
    Yu Hu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huanzhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan 430022, P R China
    Cancer Genet Cytogenet 178:1-10. 2007
  8. doi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008
  9. pmc TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells
    Siyang Zhang
    Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang, China
    BMC Cancer 10:43. 2010
  10. doi Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development
    Kristi Luberg
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    J Neurochem 113:952-64. 2010

Research Grants

  1. Lisa M Monteggia; Fiscal Year: 2016
  2. Gary B Kaplan; Fiscal Year: 2014
  3. Scott C Steffensen; Fiscal Year: 2016
  4. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
  5. SHANNON LEIGH GOURLEY; Fiscal Year: 2016
  6. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
  7. Bruce K Krueger; Fiscal Year: 2016
  8. Role of TrkB receptor and its signaling pathways in cocaine reward and addiction
    NICOLE RENEE BUZIN; Fiscal Year: 2012
  9. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2012
  10. Tomas R Guilarte; Fiscal Year: 2016

Detail Information

Publications212 found, 100 shown here

  1. doi Overexpression of TrkB promotes the progression of colon cancer
    Yingjiao Yu
    Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China
    APMIS 118:188-95. 2010
    Studies have confirmed that TrkB plays important roles in facilitating metastasis in various types of malignant tumors...
  2. ncbi Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)
    A Nakagawara
    Division of Oncology, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Genomics 25:538-46. 1995
    ..5-kb band encodes the full-length TRK-B mRNA and the 8.0-kb band encodes the truncated form of TRK-B mRNA. By fluorescence in situ hybridization and somatic cell hybrid mapping, the human TRK-B gene was localized to chromosome 9q22.1...
  3. ncbi Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan
    T B Romanczyk
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Building 10 4 N312, MSC 1385, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 15:269-80. 2002
    Signalling through tyrosine kinase receptor B (trkB) influences neuronal survival, differentiation and synaptogenesis...
  4. ncbi Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    Sirith Douma
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Nature 430:1034-9. 2004
    ..Here, we report the identification of TrkB, a neurotrophic tyrosine kinase receptor, as a potent and specific suppressor of caspase-associated anoikis of non-..
  5. ncbi Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:372-83. 2005
    ..the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia...
  6. pmc Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence
    K Xu
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 7:368-79. 2007
    ..057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD...
  7. ncbi Identification of brain-derived neurotrophic factor as a novel angiogenic protein in multiple myeloma
    Yu Hu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huanzhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan 430022, P R China
    Cancer Genet Cytogenet 178:1-10. 2007
    ..The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, TrkB, have been identified as critical factors in the regulation of vessel formation...
  8. doi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008
    ..Such mutational events could represent an important step in the cancerogenesis of these tumors and may have potential implications for the selection of patients for targeted therapy...
  9. pmc TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells
    Siyang Zhang
    Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang, China
    BMC Cancer 10:43. 2010
    Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis...
  10. doi Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development
    Kristi Luberg
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    J Neurochem 113:952-64. 2010
    ..Misregulation of TrkB has been reported in many human diseases, including cancer, obesity and neurological and psychiatric disorders...
  11. doi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
    ..Here, we found the expression of BDNF and neurtropin-4/5 together with TrkB in human trophoblastic choriocarcinoma cells...
  12. ncbi Overexpression of BDNF and TrkB in human bladder cancer specimens
    Pei Chun Lai
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Oncol Rep 24:1265-70. 2010
    BDNF (brain-derived neurotrophic factor) and TrkB (tropomyosin receptor kinase B) are expressed in several tumor types...
  13. pmc Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival
    Hussein Akil
    Universite de Limoges, Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine et de Pharmacie, Limoges, France
    PLoS ONE 6:e25097. 2011
    ..They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal cancer (CRC) cells...
  14. doi High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells
    Hiroyuki Fujikawa
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Gastroenterol 47:775-84. 2012
    The neurotrophic receptor tropomyosin related kinase (TrkB) is associated with tumor progression in neuroblastoma and certain human malignancies. Recent reports indicate TrkB may participate in the epithelial-mesenchymal transition (EMT)...
  15. pmc BDNF-TrkB signaling and neuroprotection in schizophrenia
    Chirayu D Pandya
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA
    Asian J Psychiatr 6:22-8. 2013
    ..known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB)...
  16. ncbi trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
    S P Squinto
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Cell 65:885-93. 1991
    ..both BDNF and NT-3, but not NGF, bind to full-length and truncated forms of a receptor-like tyrosine kinase, trkB, for which no ligand had previously been identified...
  17. ncbi A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics
    S F Hackett
    Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 9277, USA
    Brain Res 789:201-12. 1998
    ..RT-PCR with primers spanning the transmembrane domain demonstrated that RPE cells express trkB mRNA lacking a region homologous to exon 9 of chicken trkB, a splice variant that has been demonstrated to ..
  18. ncbi Association of the Src family tyrosine kinase Fyn with TrkB
    Y Iwasaki
    Novartis Pharma K K, Research Department, Takarazuka Research Institute, Japan
    J Neurochem 71:106-11. 1998
    ..The Fyn-Src homology domain 2 (SH2) was observed to associate in vitro with the intracellular domain of TrkB (ICD-TrkB). This association was dependent on the autophosphorylation of ICD-TrkB...
  19. pmc Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
    M Bibel
    Max Planck Institute of Neurobiology, Department of Neurobiochemistry, 82152 Planegg Martinsried, Germany
    EMBO J 18:616-22. 1999
    ..Many cells co-express trk receptors and p75(NTR), and we found that p75(NTR) was co-precipitated with trkA, trkB and trkC in cells transfected with both receptor types...
  20. ncbi Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5
    M J Banfield
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom
    Structure 9:1191-9. 2001
    ..Neurotrophin function has been implicated in a number of neurological disorders, including Alzheimer's disease and Parkinson's disease...
  21. ncbi Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism
    Peter Stoilov
    Friedrich Alexander University Erlangen, Institute for Biochemistry, Fahrstrasse 17, Erlangen, 91054, Germany
    Biochem Biophys Res Commun 290:1054-65. 2002
    We determined the gene structure of the human TrkB gene. The gene is unusually large and spans at least 590 kbp. It contains 24 exons...
  22. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ..BDNF), one of the most important neurotrophins, after binding with and activating receptor tyrosine kinase B (trk B), is directly involved in many physiological functions in the brain, including cell survival and synaptic ..
  23. ncbi Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA
    Kim N Robinson
    Laboratory of Neural Signaling, The Robarts Research Institute, London, Ontario N6A 5K8, Canada
    J Biol Chem 280:225-35. 2005
    ..These studies identify RasGrf1 as a novel target of neurotrophin activation and suggest an additional pathway whereby neurotrophin-stimulated neurite outgrowth may be regulated...
  24. ncbi A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
    ..member of the neurotrophin family of growth factors, and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), contribute to these survival cues...
  25. ncbi The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness
    Monica Hecht
    Department of Pediatrics, University of Goettingen, Germany
    Carcinogenesis 26:2105-15. 2005
    ..However, amplification of the oncogene MYCN and expression of the neurotrophin receptor TrkB are known to contribute to a highly malignant phenotype...
  26. ncbi The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas
    P Perez-Pinera
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad de Oviedo, Julian Claveria s n, Oviedo, Spain
    Mol Cell Biochem 295:19-26. 2007
    ..We showed that human lung adenocarcinomas express TrkA and TrkB, but not TrkC; A549 cells, derived from a human lung adenocarcinoma, express mRNA transcripts encoding nerve growth ..
  27. pmc Neurotrophin-regulated signalling pathways
    Louis F Reichardt
    Neuroscience Program, Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, 1550 Fourth Street, Rock Hall 284a, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 361:1545-64. 2006
    ..one or more of the three members of the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB and TrkC)...
  28. ncbi Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation
    Lihua Qiu
    Department of Ob Gyn, Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, P R China
    Int J Oncol 29:1003-11. 2006
    ..We investigated the crosstalk between EGFR and TrkB, both of which have been known to be important in cell survival and migration in response to EGF and BDNF...
  29. ncbi The pharmacogenetics of lithium response depends upon clinical co-morbidity
    Troy Bremer
    Prediction Sciences, Inc, San Diego, California, USA
    Mol Diagn Ther 11:161-70. 2007
    ..A test that could predict response to lithium based upon genetic factors would have significant clinical value...
  30. ncbi Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis
    Thomas R Geiger
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:6221-9. 2007
    ..We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic...
  31. ncbi Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium
    Dana L Anger
    Reproductive Biology Division, Department of Obstetrics and Gynecology, HSC 3N52D, McMaster University, 1200 Main Street W, Hamilton, ON, Canada
    Endocrine 31:167-73. 2007
    b>Tyrosine kinase receptor B (TrkB) gene expression, a neurotrophic factor receptor expressed in the brain and ovary, has recently been identified in deep infiltrating endometriosis by gene array...
  32. ncbi Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder
    Pino Alonso
    OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 63:619-28. 2008
    ..We used a linkage disequilibrium (LD)-mapping approach to investigate the role that BDNF and its specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) may play in increasing susceptibility to OCD.
  33. doi Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer
    Xiaohui Yu
    Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People s Hospital, No 85 Wujin Road, Shanghai 200080, China
    Cancer Sci 99:543-52. 2008
    b>TrkB is a neurotrophic tyrosine kinase receptor (Trk)...
  34. pmc A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation
    Carla Lucia Esposito
    Istituto per l Endocrinologia e l Oncologia Sperimentale G Salvatore, Consiglio Nazionale delle Ricerche CNR, Naples, Italy
    PLoS ONE 3:e1643. 2008
    ..Retinoic acid (RA)-treatment of neuroblastoma (NB) cells implicates activation of Ret and TrkB RTKs as critical step to induce cell differentiation...
  35. doi Up-regulation of Tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations
    Zhiyong Zhang
    Institute of Immunology, Shandong University School of Medicine, Jinan, China
    Mol Biol Rep 36:1211-6. 2009
    ..Expression of TrkB on detached cells was much higher than that of attached ones...
  36. doi Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers
    Carl Ernst
    Departments ofNeurology and Neurosurgery, Douglas Hospital Research Institute, Montreal, QC H4H 1R3, Canada
    Arch Gen Psychiatry 66:22-32. 2009
    ..A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived neurotrophic factor-TrkB signaling has been linked to mood ..
  37. doi Neurotrophic receptor, tropomyosin-related kinase B as an independent prognostic marker in gastric cancer patients
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    J Surg Oncol 99:307-10. 2009
    Neurotrophic receptor tyrosine kinase TrkB has been associated with clinical outcome and chemotherapy resistance in neuroblastoma and certain human malignancies...
  38. doi Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    Christy W H Au
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Lett 281:151-61. 2009
    In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients...
  39. pmc Trk receptor expression and inhibition in neuroblastomas
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Clin Cancer Res 15:3244-50. 2009
    ..In contrast, TrkB-expressing tumors frequently have MYCN amplification and are very aggressive and often fatal tumors...
  40. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
    ..3 (P=4.1 x 10(-6)), and rs7078071 in BTBD16 at 10q26.13 (P=4.5 x 10(-6)). This study is the first to conduct GWA of BD in individuals of AA and suggests that genetic variations that contribute to BD may vary as a function of ancestry...
  41. doi TrkB signalling pathways in LTP and learning
    Liliana Minichiello
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, 00015 Monterotondo, Italy
    Nat Rev Neurosci 10:850-60. 2009
    ..The receptor tyrosine kinase TrkB (also known as NTRK2), known primarily for its function during PNS and CNS development, has emerged in recent years ..
  42. doi Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
    Eugene Lin
    Vita Genomics, Inc, Taipei, Taiwan
    Rejuvenation Res 12:387-93. 2009
    ..Analyses using logistic regression models confirmed the gene-gene interactions. The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner...
  43. pmc TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma
    M E Kupferman
    Department of Head and Neck Surgery, Houston TX, USA
    Oncogene 29:2047-59. 2010
    ..and here we present experimental evidence for a direct role of the cell surface receptor tyrosine kinase, TrkB, in HNSCC tumor progression...
  44. pmc Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010
    ..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
  45. ncbi BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells
    Yen Ta Huang
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, R O C
    Int J Oncol 36:1469-76. 2010
    ..Previously, brain-derived neurotrophic factor (BDNF) but not tropomyosin-related kinase B (TrkB) was found in normal urothelium...
  46. pmc Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC
    Turker Yilmaz
    Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
    Cancer Biol Ther 10:644-53. 2010
    ..Several lines of evidence support the role of TrkB for invasion and metastasis in various solid tumor models, and we have shown an important function of this receptor ..
  47. pmc Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
    Mia Thompson Ray
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatry Neurosci 36:195-203. 2011
    Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+) and glutamic acid decarboxylase (GAD67) mRNA levels have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia...
  48. pmc Role and relevance of TrkB mutations and expression in non-small cell lung cancer
    Taishi Harada
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 17:2638-45. 2011
    b>TrkB has been involved in poor cancer outcome. TrkB mutations have been reported in non-small cell lung cancer...
  49. pmc Functional characterization of human cancer-derived TRKB mutations
    Thomas R Geiger
    Division of Molecular Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 6:e16871. 2011
    ..In human colorectal tumors, the neurotrophic receptor TRKB has been found mutated on two different sites in its kinase domain (TRKB(T695I) and TRKB(D751N))...
  50. pmc Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder
    Benchawanna Soontornniyomkij
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093 0603, USA
    J Affect Disord 133:646-54. 2011
    ..Brain-derived neurotrophic factor (BDNF)-induced activation of tyrosine kinase B (TrkB) is essential to synaptic plasticity...
  51. pmc Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia
    Jenny Wong
    Schizophrenia Research Institute, Sydney, Australia
    Schizophr Bull 39:130-40. 2013
    The truncated brain-derived neurotrophic factor (BDNF) receptors (truncated TrkB [TrkB-TK-] and sarc homology containing TrkB [TrkB-Shc]) are alternative transcripts of the full-length TrkB receptor (TrkB-TK+) that produce isoforms ..
  52. ncbi BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition
    Caroline Brunetto de Farias
    Cancer Research Laboratory, University Hospital Research Center CPE HCPA, Federal University of Rio Grande do Sul, 90035 003 Porto Alegre, RS, Brazil
    Biochem Biophys Res Commun 425:328-32. 2012
    ..The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB have recently emerged as anticancer targets, and we have previously shown increased BDNF levels in CRC tumor ..
  53. doi Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer
    Kyoko Okamura
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan
    Lung Cancer 78:100-6. 2012
    High expression levels of TrkB and BDNF are associated with aggressive malignant behavior in tumor cells and a poor prognosis in patients with various types of cancer...
  54. pmc The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice
    Zezhi Li
    Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Psychiatr Res 47:8-14. 2013
    ..Although genetic variants may play a key role in development of treatment-resistant depression (TRD), relevant research is scarce...
  55. doi Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma
    Tomonori Sasahira
    Department of Molecular Pathology, Nara Medical University School of Medicine, Kashihara, Nara 634 8521, Japan
    Hum Pathol 44:1098-106. 2013
    ..The role of Trks in cancer is still controversial. The expression and role of TrkB and TrkC were examined in colorectal cancer (CRC)...
  56. pmc EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons
    Dirk Puehringer
    Institute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany
    Nat Neurosci 16:407-15. 2013
    ..We found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are activated by ..
  57. pmc Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma
    Wei Bao
    Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 8:e70616. 2013
    ..Recent data support a role for the cell surface receptor tyrosine kinase TrkB in the progression of several human tumors. Here we present evidence for a direct role of TrkB in human EC...
  58. ncbi Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells
    N Y Ip
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591
    Neuron 10:137-49. 1993
    ..specificities, represents the functional counterpart of Xenopus neurotrophin-4 and is a "preferred" ligand for TrkB. However, its interactions with TrkB can be distinguished from those of brain-derived neurotrophic factor (BDNF) ..
  59. ncbi Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Neuron 50:549-59. 2006
    ..Unexpectedly, Nedd4-2 does not bind or ubiquitinate related TrkB receptors, due to the lack of a consensus PPXY motif...
  60. pmc Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232, USA
    Arthritis Res Ther 10:R82. 2008
    ....
  61. ncbi Retrograde axonal transport obstruction of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in the retina and optic nerve of American Cocker Spaniel dogs with spontaneous glaucoma
    Simone Iwabe
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, DF, Mexico
    Vet Ophthalmol 10:12-9. 2007
    ..optic nerve axonal transport obstruction at the scleral lamina cribosa level by examining levels of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor type B (TrkB) in dogs presenting with high intraocular pressure.
  62. ncbi Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:229-38. 2001
    ..we found: (1) a permanent reduction of brain-derived neurotrophic factor (BDNF) and its full-length receptor, TrkB, in the infarcted core; (2) a transient increase in BDNF immunoreactivity in the internal region of the border of ..
  63. ncbi Long-term locomotor training up-regulates TrkB(FL) receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord
    Malgorzata Skup
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St 02 093 Warsaw, Poland
    Exp Neurol 176:289-307. 2002
    ..In particular, brain-derived neurotrophic factor (BDNF), acting through full-length TrkB receptor (TrkB(FL)), is implicated in the stimulation of neurotransmission...
  64. ncbi Distribution of brain-derived neurotrophic factor and TrkB receptor proteins in the fetal and postnatal hippocampus and cerebellum of the guinea pig
    Sandra Dieni
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    J Comp Neurol 454:229-40. 2002
    This study investigates the distribution of brain-derived neurotrophic factor protein (BDNF) and its receptor, TrkB, during the development of hippocampus and cerebellum in a long-gestation species, the guinea pig...
  65. doi A novel trimeric peptide, Neuropep-1-stimulating brain-derived neurotrophic factor expression in rat brain improves spatial learning and memory as measured by the Y-maze and Morris water maze
    Min Kyoo Shin
    Biochemistry Laboratory, Department of Biological Science, Sungkyunkwan University, Jangan gu, Suwon, Gyeonggi Do, Korea
    J Neurochem 116:205-16. 2011
    ..Pre-treatment of TrkB inhibitor (K252a) did not block Neuropep-1-induced BDNF up-regulation...
  66. ncbi Continuous exposure to brain-derived neurotrophic factor is required for persistent activation of TrkB receptor, the ERK signaling pathway, and the induction of neuropeptide Y production in cortical cultures
    Ayalla Barnea
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Brain Res 1020:106-17. 2004
    ..In some studies, it was shown that BDNF leads to the downregulation of TrkB receptor and some of its downstream responses, whereas in others it does not...
  67. doi Involvement of brain-derived neurotrophic factor (BDNF) in the functional elimination of synaptic contacts at polyinnervated neuromuscular synapses during development
    N Garcia
    Unitat d Histologia i Neurobiologia UHN, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, Spain
    J Neurosci Res 88:1406-19. 2010
    ..use immunohistochemistry to describe the localization of brain-derived neurotrophic factor (BDNF) and its receptors trkB and p75(NTR) in the neuromuscular synapses of postnatal rats (P6-P7) during the synapse elimination period...
  68. doi Immunolocalization of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1354:1-14. 2010
    Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are essential in promoting normal development of the central nervous system...
  69. pmc Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
    Antonio Postigo
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 16:633-45. 2002
    Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons...
  70. ncbi Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
    M A Gates
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 98:437-47. 2000
    The spatial and temporal expression of the protein-tyrosine kinase B (TrkB) receptor and its ligands has been correlated with the development of the neocortex...
  71. ncbi Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum
    K E Light
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Brain Res Mol Brain Res 93:46-55. 2001
    ..We hypothesize that disruption of TrkB and/or TrkC mediated neurotrophin communication is, in part, responsible for the ethanol-induced loss of Purkinje ..
  72. ncbi A role for the neurotrophin receptor TrkB on maturing dendritic cells
    Kai Bratke
    Department of Pneumology, University of Rostock, Germany
    J Neuroimmunol 189:88-94. 2007
    ..Neurotrophins are involved in neuroimmune interactions. However, the expression and role of neurotrophin receptors on dendritic cells have not been systematically studied...
  73. ncbi An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study
    Marzena Mackowiak
    Eli Lilly and Co Ltd, Lilly Corporate Center, Indianapolis, IN 46285 0814, USA
    Neuropharmacology 43:1-10. 2002
    ..potentiator (LY404187) and its active isomer (LY451646) on the expression of BDNF protein and mRNA, as well as TrkB mRNA in rat hippocampus...
  74. ncbi Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 101:383-92. 2001
    Recent evidence suggests that brain-derived neurotrophic factor (BDNF) and its tyrosine kinase B (TrkB) receptor, in addition to promoting neuronal survival and differentiation, modulates synaptic transmission by increasing N-methyl-D-..
  75. doi Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human
    S Mayeur
    Univ Lille Nord de France, F 59000 Lille, France
    Placenta 31:785-91. 2010
    ..undernutrition (MU), during the perinatal life, modified both the BDNF and its functional receptor, the tyrosine kinase receptor B (TrkB) gene expression in the brain of growth-restricted rat offspring during sensitive developmental ..
  76. pmc Effects of trkB knockout on topography and ocular segregation of uncrossed retinal projections
    Jennifer Rodger
    Experimental and Regenerative Neurosciences, School of Animal Biology M317, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Exp Brain Res 195:35-44. 2009
    b>TrkB is an important receptor for brain-derived neurotrophic factor and NT4, members of the neurotrophin family. TrkB signaling is crucial in many activity-dependent and activity-independent processes of neural development...
  77. ncbi Gene dosage effect of the TrkB receptor on rod physiology and biochemistry in juvenile mouse retina
    B Rohrer
    Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Vis 7:288-96. 2001
    To strengthen our understanding about the role of trkB in rod development by correlating functional and biochemical retinal phenotypes with levels of trkB expression in two independently created trkB transgenic lines.
  78. doi A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats
    Nadine Zeeni
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, AgroParisTech, 16 rue Claude Bernard, F 75005 Paris, France
    Brain Res 1289:49-55. 2009
    Brain-derived neurotrophic factor (BDNF) and its TrkB receptor play critical roles in the synaptic activity and plasticity of mature neurons and enhance adult neurogenesis...
  79. doi Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation
    Luc De Vries
    Department of Cellular and Molecular Biology, Institut de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Cell Signal 22:158-65. 2010
    We developed a cellular Bioluminescent Resonance Energy Transfer (BRET) assay based on the interaction of TrkB fused to Renilla luciferase with the intracellular adaptor protein Shc fused to Enhanced Yellow Fluorescent Protein (EYFP)...
  80. ncbi Locomotion induces changes in Trk B receptors in small diameter cells of the spinal cord
    M Skup
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 60:371. 2000
    ..If exercise enhances BDNF expression also in the spinal cord, upregulation of its receptor Trk B may occur. To verify this hypothesis we tested whether exercise influences TrkB receptor system in the spinal cord...
  81. doi The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals
    Neus Garcia
    Unitat d Histologia i Neurobiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, 43201 Reus, Spain
    J Neurosci 30:16514-22. 2010
    ..brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4) and the receptors tropomyosin-related kinase B (trkB) and p75(NTR) are present in the nerve terminals on the neuromuscular junctions (NMJs) of the levator auris longus ..
  82. ncbi Expression of TrkB in the murine kidney
    Olivia Garcia-Suarez
    Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, Oviedo, and Servicio de Urologia, Hospital Clinico, Universidad de Valladolid, Spain
    Microsc Res Tech 69:1014-20. 2006
    ..study we used Western-blot and immunohistochemistry to investigate the occurrence and cellular localization of TrkB in the mouse kidney...
  83. ncbi Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain
    Eija Koponen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Brain Res Mol Brain Res 130:81-94. 2004
    ..To specifically address the role of the trkB receptor, we have previously generated transgenic mice overexpressing the full-length trkB receptor and observed a ..
  84. pmc Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
    F F Eide
    Department of Neurology, University of Chicago, Illinois 60637, USA
    J Neurosci 16:3123-9. 1996
    b>trkB encodes a receptor tyrosine kinase activated by three neurotrophins--brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5...
  85. ncbi Expression of TrkB receptor isoforms in the developing avian visual system
    A S Garner
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci 16:1740-52. 1996
    The expression of novel TrkB receptor transcripts has been characterized to understand the potentially diverse roles of brain-derived neurotrophic factor (BDNF) in the developing avian visual system...
  86. ncbi [Expression of the neurotrophin-receptor TrkB predicts outcome in nephroblastomas: results of a pilot-study]
    A Eggert
    Universitätskinderklinik Essen, Abteilung für Hämatologie Onkologie, Germany
    Klin Padiatr 213:191-6. 2001
    The neurotrophin-receptor TrkB plays an important role in pathogenesis, biology and prognosis of neuroblastoma...
  87. ncbi Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus
    Xiao Ping He
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7502-8. 2002
    Genetic and pharmacological perturbations suggest that tyrosine receptor kinase B (trkB) receptor activation promotes limbic epileptogenesis, but whether or where trkB activation occurs during epileptogenesis is uncertain...
  88. ncbi Circadian variations in expression of the trkB receptor in adult rat hippocampus
    Claudia Dolci
    Dipartimento di Anatomia Umana, Universita di Milano, Via Mangiagalli 31, Milan I 20133, Italy
    Brain Res 994:67-72. 2003
    ..neurotrophic factor (BDNF) in the central nervous system (CNS) and the expression of its high-affinity trkB receptor on neuron surfaces are known to depend on neuron activity...
  89. ncbi Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
    Matthias Hartmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany
    J Cell Sci 117:5803-14. 2004
    ..The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system...
  90. ncbi Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Silvia Gines
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur J Neurosci 23:649-58. 2006
    ..However, the effectiveness of BDNF may depend on the proper expression of its receptor TrkB. In this study, we analysed the expression of TrkB in several HD models and in postmortem HD brains...
  91. ncbi Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity
    J Gray
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 31:359-64. 2007
    The neurotrophin receptor TrkB has been implicated in the regulation of energy homeostasis in rodents...
  92. ncbi Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkB neurotrophin receptor gene
    Lina K Martens
    Institut für Vegetative Physiologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biol Chem 282:14379-88. 2007
    ..High expression levels of the neurotrophin receptor TrkB and its ligands in neuroblastomas are associated with an unfavorable outcome...
  93. ncbi Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development
    Paul B Bernard
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
    Hippocampus 17:1121-33. 2007
    ..Herein we report further hippocampal changes, consisting of mossy fiber sprouting and associated changes in the trkB receptor population in young adult (3 months) rats, and further, report that these changes show regional variation ..
  94. pmc Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Hippocampus 18:435-9. 2008
    ..BDNF) is implicated in the regulation of adult hippocampal neurogenesis, presumably via its primary receptor, TrkB. However, controversy exists about how BDNF affects neurogenesis (e.g., proliferation vs. survival/differentiation)...
  95. doi Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats
    Amine Bahi
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 199:169-82. 2008
    ..BDNF action is mediated by the TrkB receptor-tyrosine kinase, and both BDNF and TrkB transcripts are widely expressed in the rat mesolimbic pathway, ..
  96. pmc Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1
    Shu Hong Huang
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Jinan, Shandong 250012, China
    J Biol Chem 284:15126-36. 2009
    Brain-derived neurotrophic factor (BDNF) signaling through its receptor, TrkB, modulates survival, differentiation, and synaptic activity of neurons. Both full-length TrkB (TrkB-FL) and its isoform T1 (TrkB...
  97. doi Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface
    Ling Zhao
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Shandong University, Shandong, P R China
    J Cell Sci 122:3123-36. 2009
    Activity-dependent insertion of tyrosine kinase receptor type 2 (TrkB receptor) into the plasma membrane can explain, in part, the preferential effect of brain-derived neurotrophic factor (BDNF) on active neurons; however, the detailed ..
  98. pmc TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine
    Kristy R Crooks
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 58:1067-77. 2010
    ..However, it is unclear whether BDNF signaling through the TrkB receptor can mediate these behavioral responses when animals are given a single cocaine exposure...
  99. pmc Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
    Jing Du
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892 4480, USA
    J Cell Biol 163:385-95. 2003
    ..that neuronal activity facilitates the internalization of the receptor for brain-derived neurotrophic factor, TrkB, by potentiating its tyrosine kinase activity...
  100. ncbi Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies
    Oliver Von Bohlen Und Halbach
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 59:793-800. 2006
    ..Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning...
  101. ncbi Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse
    Rosemary Kraemer
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 112:3644-53. 2005
    ..the Trk receptor tyrosine kinases, are potent chemotactic factors for smooth muscle cells, and the expression of brain-derived neurotrophic factor (BDNF) and its cognate receptor, TrkB, is upregulated in human atherosclerotic lesions.

Research Grants70

  1. Lisa M Monteggia; Fiscal Year: 2016
    ..neurotrophic factor (BDNF) is the most prevalent neurotrophin in brain;via actions on its high affinity trkB receptor it enhances the survival of many types of central neurons and is implicated in several forms of neural ..
  2. Gary B Kaplan; Fiscal Year: 2014
    ..Our aims will examine the BDNF and neurotrophic tyrosine kinase receptor (TrkB) receptor mechanisms in mesolimbic dopamine and prefrontal cortical neurons during COR and its extinction...
  3. Scott C Steffensen; Fiscal Year: 2016
    ..and receptor expression, as well as the role of brain-derived neurotrophic factor (BDNF) tyrosine kinase B (TrkB) receptors in mediating the functional switch of GABA(A)Rs during ethanol dependence...
  4. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..These compounds readily crossed the blood brain barrier and into the cochlea. They activated TrkB receptors at extremely low concentrations...
  5. SHANNON LEIGH GOURLEY; Fiscal Year: 2016
    ..critical to postnatal structural refinement: Brain-derived Neurotrophic Factor binding to the high- affinity trkB receptor and formation of the p120RasGAP-p190RhoGAP signaling complex...
  6. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..Our preliminary data on potential mechanisms of BDNF effects indicate that: 1) blockade of BDNF binding to TrkB receptor attenuates BDNF-inhibited feeding;2) blockade of CRH receptor (CRHR) signaling attenuates BDNF-inhibited ..
  7. Bruce K Krueger; Fiscal Year: 2016
    ..interneurons are altered by embryonic exposure to VPA;and 3) the role of altered BDNF signaling, through the trkB receptor, in mediating the effects of VPA on embryonic forebrain neurogenesis and cognition...
  8. Role of TrkB receptor and its signaling pathways in cocaine reward and addiction
    NICOLE RENEE BUZIN; Fiscal Year: 2012
    ..in the propensity for relapse, the proposed research will examine the role of tropomyosin-related kinase B (TrkB) receptors and its distinct signaling pathways in cocaine addiction...
  9. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2012
    ..two neurotrophins, BDNF and NT4, can influence various aspects of neural innervation through the same receptors, TrkB and p75...
  10. Tomas R Guilarte; Fiscal Year: 2016
    ..we propose to 1) characterize the effects of low [Pb2+] exposure on BDNF gene expression, promoter methylation and TrkB receptor activation, and 2) test the ability of an enriched environment, exogenous intraventricular BDNF infusion ..
  11. Yue Feng; Fiscal Year: 2015
    ..is a key player that governs neuronal survival, differentiation and synaptic plasticity via activation of the TrkB receptor...
  12. Subhash C Pandey; Fiscal Year: 2016
    ..It is also unknown how the expression of Arc and various exons of BDNF and its receptor, tyrosine kinase B (trkB)-linked signaling [cAMP responsive-element binding protein (CREB) and extracellular regulated protein kinases 1/2 (..
  13. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..A2a-induced phrenic motor facilitation requires TrkB receptor phosphorylation but does not require the TrkB ligand, BDNF...
  14. Christine M Gall; Fiscal Year: 2015
    ..rodent models;iii) test if chronic up-regulation of BDNF protein content increases signaling through BDNF's TrkB receptor and actin regulatory cascades as assessed in vitro and in vivo;and iv) test the prediction that the latter ..
  15. SYNAPTIC INTERACTIONS AND MECHANISMS IN THE RETINA
    DAVID RICHARD COPENHAGEN; Fiscal Year: 2013
    ..Factor) is down regulated by visual deprivation and it plays a critical role, through activation of the TrkB receptor, in governing the refinement of more diffuse dendritic arbors of ON-OFF type ganglion cells into more ..
  16. Subimal Datta; Fiscal Year: 2016
    ..by the interaction between brain-derived neurotrophic factor (BDNF) receptors (tropomyosin-related kinase B [TrkB]) and extracellular signal-regulated kinase1/2 (ERK1/2) signaling in the CCC-PPT and SubCD...
  17. Gary C Sieck; Fiscal Year: 2016
    ..g., brain- derived neurotrophic factor - BDNF) acting through tropomyosin related kinase receptors (e.g., TrkB) play an important role in neuroplasticity...
  18. BDNF/TrkB Regulates Actin Signaling with LTP
    Lulu Chen; Fiscal Year: 2009
    ..The proposed research will investigate the role of endogenous BDNF signaling via its TrkB receptor in activity-induced remodeling of the dendritic spine actin cytoskeleton and synapse size in association ..
  19. The role of TrkB signaling in the survival and function of striatal neurons.
    Maryna Baydyuk; Fiscal Year: 2010
    ..In this application, we will investigate the role of brain derived neurotrophic factor (BDNF) signaling via its TrkB tyrosine kinase receptor in the survival, maintenance, development, and function of different neuronal populations ..
  20. ROLE OF BDNF IN THE PHOTIC CONTROL OF CIRCADIAN RHYTHMS
    David Earnest; Fiscal Year: 2003
    ..determine: whether retinohypothalamic tract (RHT) fibers innervating the SCN or cells receiving RHT input express TrkB tyrosine kinase receptors, the cognate receptor for BDNF, using imunochistochemical and tract tracing methods and ..
  21. DAVID ALLAN PRINCE; Fiscal Year: 2016
    ..A neurotrophic protein BDNF, and its receptor TrkB, are important for development, growth and maintenance of interneurons, and are reduced in the injured area, ..
  22. Alpaslan Dedeoglu; Fiscal Year: 2014
    ..Most recently, 7,8-DHF was shown to bind with high affinity to the TrkB receptor and provoke its dimerization and autophosphorylation, leading to downstream-signaling cascade activation...
  23. John David Sweatt; Fiscal Year: 2014
    ..to determine precisely how chemotherapeutic drugs alter BDNF expression and that of the BDNF receptor, tyrosine kinase receptor B (trkB) are crucial first steps...
  24. Lucas D Pozzo-Miller; Fiscal Year: 2014
    ..BDNF release from granule cell mossy fibers;(4) test if enhancing BDNF expression or mimicking BDNF/TrkB signaling prevents hippocampal hyperexcitability in Mecp2 null mice and dentate granule cell-specific Mecp2 ..
  25. THOMAS N WICHMANN; Fiscal Year: 2015
    ..Project 3 (Dr. Miller) is a series of translational experiments that examine the use of orally active TrkB receptor agonists as symptomatic or neurorestorative treatment for Parkinson's disease in different rodent and ..
  26. AC1 and AC8 as Mediators of the Dendritic Response to Ethanol in a Model of FASD
    Laura Susick; Fiscal Year: 2013
    ..BDNF has been shown to regulate dendritic growth and spine development through its interaction with the trkB receptor. BDNF expression has also been shown to be modulated by ethanol in various regions of the neonatal brain...
  27. Neurotrophic Mechanisms in Retinal Ganglion Cell Maturation
    Xiaorong Liu; Fiscal Year: 2011
    ..BDNF and NT-3 signaling through their respective cognate receptor tyrosine kinases, TrkB and TrkC, are known to regulate the survival, development, and function of neurons in the brain...
  28. STEPHEN CANNADA HARWARD; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): TrkB activation is critical for many aspects of neuronal physiology such as the survival and differentiation of developing neurons as well as the formation, function, and plasticity of synapses...
  29. Baoji Xu; Fiscal Year: 2014
    ..synthesis of mutant htt in dendrites plays a key role in the HD pathogenesis and that differential expression of TrkB (the receptor for BDNF) in MSNs contributes to selective degeneration in HD...
  30. Presynaptic Structural Plasticity in the Amygdala with Fear Conditioning
    AMY LOUISE MAHAN; Fiscal Year: 2011
    ..Finally, in Aim 3) we will examine whether presynaptic TrkB is mechanistically implicated in the structural changes by constructing a virus that expresses both dominant ..
  31. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2010
    ..for the dendritic arborization and maintenance of MSNs in the indirect pathway and that differential expression of TrkB (the receptor for BDNF) in MSNs contributes to selective degeneration in HD...
  32. Adenosine A2A receptor cross-activation of TrkB in Huntington's disease
    Donald C Lo; Fiscal Year: 2012
    ..candidate targets/pathways that have increasingly been implicated in HD: the adenosine 2A receptor (A2AR) and the TrkB receptor...
  33. Eric S Levine; Fiscal Year: 2016
    ..expressed throughout the sensory, motor, and association cortices, and there is a striking overlap of expression of trkB neurotrophin receptors and type 1 cannabinoid (CB1) receptors across cortical layers, with highest levels of ..
  34. Haifei Shi; Fiscal Year: 2015
    ..conditionally deleting the BDNF gene or reducing expression of its specific receptor tropomyosin- related kinase B (TrkB) leads to hyperphagia and obesity, with females having more potent phenotypes and developing more severe obesity ..
  35. John R Grider; Fiscal Year: 2016
    ..In AIM 2, we will use pharmacological, biochemical, and molecular tools to identify the receptors (TrkB, p75, and sortilin) and intracellular signaling pathways (PLC-gamma, PI-3-K/AKT, ERK1/2, Rho/Rock) activated by ..
  36. Liya Qiao; Fiscal Year: 2016
    ..Our publications and preliminary data have shown that the brain-derived neurotrophic factor (BDNF)/TrkB system has a prominent role in the regulation of bladder activity...
  37. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..In AIM 2, we will use pharmacological, biochemical, and molecular tools to identify the receptors (TrkB, p75, and sortilin) and intracellular signaling pathways (PLC-gamma, PI-3-K/AKT, ERK1/2, Rho/Rock) activated by ..
  38. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..endothelial growth factor (VEGF), its receptor VEGFR-2, brain derived neurotrophic factor (BDNF), its receptor TrkB will be used to identify their expression in HF cells...
  39. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
    ..Moreover, number of TrkB agonist molecules does not cross blood-brain-barrier. Recently, work by our collaborator, Dr...
  40. Vagal Nerve Stimulation &Antidepressants: c-Fos, deltaFosB and TrkB Activation
    Alan Frazer; Fiscal Year: 2012
    ..or norepinephrine and/or brain- derived neurotrophic factor containing neurons (through phosphorylation of TrkB receptors)...
  41. SHANNON LEIGH GOURLEY; Fiscal Year: 2014
    ..2) selectively manipulate the high-affinity BDNF receptor, trkB. This is essential because although BDNF is implicated in addiction etiology, its receptor target in this context ..
  42. Anilkumar Pillai; Fiscal Year: 2016
    ..signaling in depressive behavior is substantiated by studies showing decreased levels of BDNF and its receptor, TrkB in postmortem brain as well as peripheral tissues of depressed subjects...
  43. Neural Control of Vasopressin Release
    J Thomas Cunningham; Fiscal Year: 2013
    ..Brain derived neurotrophic factor (BDNF) and its receptor TrkB are expressed by magnocellular neurosecretory cells that secrete vasopressin into circulation...
  44. Bradley J Undem; Fiscal Year: 2016
    ..neurotrophic factor (BDNF/NT3) and/or glial cell-derived neurotrophic factor ligands (GFLs) interacting with the TRKB and GFR[unreadable] receptors, respectively...
  45. Robert G Kalb; Fiscal Year: 2015
    ..b>TrkB is activated by its ligand, brain-derived neurotrophic factor...
  46. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..role ameliorating anxiety and memory dysfunctions and in modulating the expression of BDNF and its receptor TrkB in the hippocampus, a region critically involved in anxiety and memory...
  47. Baoji Xu; Fiscal Year: 2014
    ..factor (BDNF) plays crucial roles in energy balance, as mutations in the genes for BDNF and its receptor TrkB lead to obesity in both mice and humans;however, the precise role of BDNF in the regulation of body weight remains ..
  48. Maribel Rios; Fiscal Year: 2014
    ..Mounting evidence indicates that the brain-derived neurotrophic factor (BDNF)/TrkB pathway plays a critical part in energy balance regulation and is a promising target for novel therapies...
  49. Arthur W English; Fiscal Year: 2016
    ..axons regenerate successfully, and the expression of brain derived neurotrophic factor (BDNF) and its receptor, trkB, in motoneurons, dorsal root ganglion neurons, and growth cones of regenerating axons will be studied both in ..
  50. Prefrontal Cortex BDNF and Amygdala-Dependent Emotional LearningChallenge Area:
    Kerry J Ressler; Fiscal Year: 2010
    ..BDNF is highly expressed in the medial prefrontal cortex and its tyrosine kinase receptor B (TrkB) is required for amygdala-dependent conditioning...
  51. Masuo Ohno; Fiscal Year: 2014
    ..provided by applicant): Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) play a crucial role in neuronal plasticity and survival...
  52. Nicotine, Neurotrophins and Depression
    Yousef Tizabi; Fiscal Year: 2009
    ..Behavioral analyses will include Porsolt forced swim test and general locomotor activity. BDNF and TrkB containing neurons will be quantified by immunocytochemical and state of the art stereological techniques...
  53. Mechanism of Brain-Specific Angiogenesis Inhibitor 1 (BAI1) in Neural Development
    Joseph G Duman; Fiscal Year: 2013
    ..the activation of Rac through Tiam1 in response to brain-derived neurotrophic factor through its receptor TrkB. During this time, the candidate will participate in a variety of neuroscience teaching exercises, both formal and ..
  54. Pathological retrograde signaling in ALS
    Robert G Kalb; Fiscal Year: 2010
    The activation of the receptor TrkB by brain derived neurotrophic factor (BDNF) supports the survival of pure motor neurons in vitro and rescues motor neurons in some in vivo lesion paradigms...
  55. Cheryl F Dreyfus; Fiscal Year: 2016
    ..Work in our lab during the previous funding period indicates that BDNF, through the mediation of TrkB, influences proliferation and differentiation of OLG subpopulations in culture...
  56. AJAY THOMAS; Fiscal Year: 2014
    ..appear to play contrary roles in the nervous system since they primarily activate different receptors, p75NTR and TrkB, respectively...
  57. John R Kelsoe; Fiscal Year: 2015
    ..These studies found evidence for two genes predicting response to lithium. NTRK2 codes for the trkb receptor which is the receptor for BDNF also implicated in bipolar disorder...
  58. Sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
    Lingjun Zuo; Fiscal Year: 2012
    ..The expected findings would significantly contribute to the improvement of public health. ..
  59. Investigating protein dynamics in NT-4/5 and TrkB receptor interactions
    Karin A Crowhurst; Fiscal Year: 2012
    ..Trk receptor takes place at the immunoglobulin-like domain 5 in the extracellular portion of the Trk receptor (TrkB-d5), but there is also evidence that the long flexible linker region spanning the Trk sequence between domain 5 and ..
  60. Allan I Levey; Fiscal Year: 2016
    ..Project 3, "Norepinephrine-TrkB Interactions in Alzheimer's Disease" (Dr...
  61. A universal photoswitch system for optical control of neuronal receptors
    Richard H Kramer; Fiscal Year: 2012
    ..We will test the effectiveness of the Universal Photoswitch approach on two example receptors: the TrkB receptor for brain-derived growth factor (BDNF), a member of the neurotrophin family of receptor tyrosine kinases, ..
  62. Axonal Sprouting, Neurotrophins, and Posttraumatic Epilepsy
    Stephanie Aungst; Fiscal Year: 2012
    ..by CA3 cells after Schaffer collateral transection, delayed hyperexcitability, and up-regulation of BDNF and trkB receptors...
  63. Huntington's Disease and the Striatum
    Michelle E Ehrlich; Fiscal Year: 2010
    ..And 2) Does loss of striatal brain-derived neurotrophic factor (BDNF) function via deletion of post-synaptic trkB receptors in the adult exacerbate an HD phenotype in a mouse model? Using this new mouse model and the knowledge of ..
  64. Visualizing synaptic circuitry in the retina
    Xandra Breakefield; Fiscal Year: 2006
    ..virion will be replaced with BDNF to increase infection of retinal ganglion cells that express high levels of the TrkB receptor on their cell surface...
  65. Supraspinal BDNF Signaling Modulates Nociception
    SUSAN DORSEY; Fiscal Year: 2006
    ..A key regulator of LTP is BDNF, which exerts its effects by activating the tyrosine kinase receptor trkB. The trkB locus also produces a truncated receptor (T1) that inhibits BDNF signaling...
  66. TrkB & Synapse Elimination in the Developing Cerebellum
    Erin Johnson; Fiscal Year: 2007
    ..on investigating the maturation of the climbing fiber-Purkinje cell synapse and to test the hypothesis that the TrkB receptor plays a role in regulating the switch from multiple to single climbing fiber innervation of Purkinje cells ..
  67. FUNCTION OF RETINAL TRKB RECEPTOR ISOFORMS
    RICHARD ZIGMOND; Fiscal Year: 1999
    ..The actions of BDNF are mediated principally by the trkB receptor, expressed widely in the retina, tectum and other visual nuclei...
  68. Regulation of food intake and body weight by dendritically synthesized BDNF
    Baoji Xu; Fiscal Year: 2009
    Brain-derived neurotrophic factor (BDNF) and its TrkB receptor have been implicated in the control of energy balance in both humans and mice...
  69. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ..to determine the time course and extent of changes in local blood flow, tissue hypoxia, NMJs, and BDNF, NT-4, and trkB (the receptor for both BDNF and NT-4) expression in the genitourinary organs due to vaginal distensions of ..
  70. GROWTH FACTORS IN MAMMALIAN EYE DEVELOPMENT
    Jeffrey Bennett; Fiscal Year: 2002
    ..First, the cell specific expression of BDNF and NT-3 and their respective receptors. TrkB and TrkC, will be examined in the neuroretina, lens, ciliary body, and cornea...