tristetraprolin

Summary

Gene Symbol: tristetraprolin
Description: ZFP36 ring finger protein
Alias: G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, mRNA decay activator protein ZFP36, G0/G1 switch regulatory protein 24, growth factor-inducible nuclear protein NUP475, tristetraprolin, tristetraproline, zinc finger protein 36 homolog, zinc finger protein 36, C3H type, homolog, zinc finger protein, C3H type, 36 homolog
Species: human

Top Publications

  1. pmc Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress
    Brent Holmes
    Department of Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 91343, USA
    Cell Signal 24:309-15. 2012
  2. ncbi Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells
    Olivier Boutaud
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Adv Exp Med Biol 525:157-60. 2003
  3. ncbi Inherent instability of plasminogen activator inhibitor type 2 mRNA is regulated by tristetraprolin
    Hong Yu
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    J Biol Chem 278:13912-8. 2003
  4. pmc Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs
    Audrey Esclatine
    The Marjorie B Kovler Viral Oncology Labs, The University of Chicago, 910 E 58th St, Chicago, IL 60637, USA
    J Virol 78:8582-92. 2004
  5. ncbi A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence
    R N DuBois
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 265:19185-91. 1990
  6. pmc The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes
    G A Taylor
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710
    Nucleic Acids Res 19:3454. 1991
  7. ncbi Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein
    W S Lai
    Howard Hughes Medical Institute Laboratories, Durham, North Carolina 27710
    J Biol Chem 265:16556-63. 1990
  8. ncbi Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    E Carballo
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Science 281:1001-5. 1998
  9. pmc Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
    W S Lai
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 19:4311-23. 1999
  10. ncbi Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA
    W S Lai
    Office of Clinical Research and Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:17827-37. 2000

Research Grants

  1. "Development of a Laboratory Test for TTP"
    Christopher Hillyer; Fiscal Year: 2003
  2. X Long Zheng; Fiscal Year: 2016
  3. Ph 3 of Cyclosporine or Corticosteroids Adjunct to Plasma Exhcange in Tx of TTP
    Haifeng M Wu; Fiscal Year: 2013
  4. VON WILLEBRAND FACTOR AND THE PATHOPHYSIOLOGY OF TTP
    Joel Moake; Fiscal Year: 1990
  5. Timothy A Springer; Fiscal Year: 2015
  6. David Ginsburg; Fiscal Year: 2016
  7. Xiaoping Du; Fiscal Year: 2016
  8. Von Willebrand Factor Multimer Assembly and Structure
    J Evan Sadler; Fiscal Year: 2012
  9. Regulation of von Willebrand Factor Reactivity
    JOSE ARON LOPEZ; Fiscal Year: 2012
  10. BIOMECHANICS OF UNFOLDING THE A2 DOMAIN OF VON WILLEBRAND FACTOR
    Jin Yu Shao; Fiscal Year: 2012

Detail Information

Publications203 found, 100 shown here

  1. pmc Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress
    Brent Holmes
    Department of Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 91343, USA
    Cell Signal 24:309-15. 2012
    The A/U-rich RNA-binding protein tristetraprolin (TTP) is an mRNA destabilizing factor which plays a role in the regulated turnover of many transcripts encoding proteins involved in immune function and cell growth control...
  2. ncbi Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells
    Olivier Boutaud
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Adv Exp Med Biol 525:157-60. 2003
  3. ncbi Inherent instability of plasminogen activator inhibitor type 2 mRNA is regulated by tristetraprolin
    Hong Yu
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    J Biol Chem 278:13912-8. 2003
    ..This screen identified tristetraprolin (TTP) as a PAI-2 mRNA ARE-binding protein...
  4. pmc Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs
    Audrey Esclatine
    The Marjorie B Kovler Viral Oncology Labs, The University of Chicago, 910 E 58th St, Chicago, IL 60637, USA
    J Virol 78:8582-92. 2004
    ..Roizman, Proc. Natl. Acad. Sci. USA 101:3603-3608, 2004). Among the latter was the RNA encoding tristetraprolin, a protein that binds AREs and is known to be associated with the degradation of RNAs containing AREs...
  5. ncbi A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence
    R N DuBois
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 265:19185-91. 1990
    ..The cDNA encodes a proline-, serine-, and glycine-rich nuclear protein designated Nup475 of 319 amino acids that contains two tandemly repeated cysteine- and histidine-containing sequences (CX8CX5CX3H) ..
  6. pmc The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes
    G A Taylor
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710
    Nucleic Acids Res 19:3454. 1991
  7. ncbi Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein
    W S Lai
    Howard Hughes Medical Institute Laboratories, Durham, North Carolina 27710
    J Biol Chem 265:16556-63. 1990
    ..4 mol %) and contained three Pro-Pro-Pro-Pro repeats, we have tentatively labeled it tris-tetraprolin (TTP)...
  8. ncbi Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    E Carballo
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Science 281:1001-5. 1998
    ..b>Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-His (CCCH) zinc finger proteins, inhibited TNF-alpha ..
  9. pmc Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
    W S Lai
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 19:4311-23. 1999
    Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins, develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-alpha)...
  10. ncbi Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA
    W S Lai
    Office of Clinical Research and Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:17827-37. 2000
    Macrophages derived from tristetraprolin (TTP)-deficient mice exhibited increased tumor necrosis factor alpha (TNFalpha) release as a consequence of increased stability of TNFalpha mRNA...
  11. ncbi AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
    C Y Chen
    Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 107:451-64. 2001
    ..The mammalian exosome does not recognize ARE-containing RNAs on its own. ARE recognition requires certain ARE binding proteins that can interact with the exosome and recruit it to unstable RNAs, thereby promoting their rapid degradation...
  12. pmc Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover
    Georg Stoecklin
    Institute of Medical Microbiology, University of Basel, Petersplatz 10, 4003 Basel, Switzerland
    EMBO J 21:4709-18. 2002
    ..The cDNA was identified as butyrate response factor-1 (BRF1), encoding a zinc finger protein homologous to tristetraprolin. Mutant slowC carries frame-shift mutations in both BRF1 alleles, whereas slowB with intermediate decay ..
  13. ncbi Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover
    P J Blackshear
    Office of Clinical Research and the Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem Soc Trans 30:945-52. 2002
    The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three known members in mammals, with a fourth member recently identified in frogs and fish...
  14. ncbi Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site
    Hitoshi Sawaoka
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:13928-35. 2003
    ..b>Tristetraprolin, an mRNA-binding protein that promotes message instability, was shown to bind the cyclooxygenase-2 mRNA in ..
  15. pmc Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases
    Heping Cao
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Mail Drop F3 04, Research Triangle Park, NC 27709, USA
    Arch Biochem Biophys 412:106-20. 2003
    b>Tristetraprolin (TTP) is an mRNA-binding protein, but studies of this interaction have been difficult due to problems with the purification of recombinant TTP...
  16. ncbi Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin)
    Sarah L J Michel
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 42:4626-30. 2003
    ..The protein Nup475 (also known as Tristetraprolin and TS11) binds to AU-rich sequence elements in certain mRNA molecules and favors the degradation of these ..
  17. pmc Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease
    Wi S Lai
    Laboratory of Signal Transduction Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 23:3798-812. 2003
    Eukaryotic mRNA stability can be influenced by AU-rich elements (AREs) within mRNA primary sequences. Tristetraprolin (TTP) is a CCCH tandem zinc finger protein that binds to ARE-containing transcripts and destabilizes them, apparently ..
  18. ncbi MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
    Carol A Chrestensen
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Biol Chem 279:10176-84. 2004
    MAPKAP kinase 2 (MK2) is required for tumor necrosis factor synthesis. Tristetraprolin (TTP) binds to the 3'-untranslated region of tumor necrosis factor mRNA and regulates its fate...
  19. pmc MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004
    ..Here we show that tristetraprolin (TTP), an ARE-binding protein that destabilizes ARE-mRNAs, is recruited to SGs that are assembled in response ..
  20. ncbi RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs
    Brandy Y Brewer
    Department of Biochemistry and Molecular Biology, Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, 108 N Greene Street, Baltimore, MD 21201, USA
    J Biol Chem 279:27870-7. 2004
    b>Tristetraprolin (TTP) binds AU-rich elements (AREs) encoded within selected labile mRNAs and targets these transcripts for rapid cytoplasmic decay...
  21. ncbi The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway
    Seth A Brooks
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 172:7263-71. 2004
    b>Tristetraprolin (TTP) is a regulator of TNF-alpha mRNA stability and is the only trans-acting factor shown to be capable of regulating AU-rich element-dependent mRNA turnover at the level of the intact animal...
  22. pmc The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis
    Danielle M Carrick
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Arthritis Res Ther 6:248-64. 2004
    b>Tristetraprolin (TTP) is the best-studied member of a small family of three proteins in humans that is characterized by a tandem CCCH zinc finger (TZF) domain with highly conserved sequences and spacing...
  23. ncbi Involvement of microRNA in AU-rich element-mediated mRNA instability
    Qing Jing
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 120:623-34. 2005
    ..The role of miR16 in ARE-RNA decay is sequence-specific and requires the ARE binding protein tristetraprolin (TTP)...
  24. ncbi Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene
    Marcel Fechir
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
    Mol Pharmacol 67:2148-61. 2005
    ..protein regulated by the p38 MAPK pathway and involved in the regulation of the stability of several mRNAs is tristetraprolin. RNase protection, quantitative real-time polymerase chain reaction, and Western blot experiments showed that ..
  25. pmc Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis
    Heping Cao
    Laboratories of Neurobiology and Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Biochem J 394:285-97. 2006
    b>Tristetraprolin (TTP) is a zinc-finger protein that binds to AREs (AU-rich elements) within certain mRNAs and causes destabilization of those mRNAs...
  26. ncbi Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping
    Martin Fenger-Grøn
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309, USA
    Mol Cell 20:905-15. 2005
    ..Specific decapping factors interact with the mRNA decay activators hUpf1 and TTP, and TTP enhances decapping of a target AU-rich element (ARE) RNA in vitro...
  27. ncbi Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin
    Willmar D Patino
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Circ Res 98:1282-9. 2006
    ..Consistent with its role in moderating inflammation, tristetraprolin (TTP, ZFP36) was among the most highly expressed macrophage transcriptional regulators...
  28. ncbi Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA
    Lei Sun
    Division of Critical Care, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:3766-77. 2007
    ..Post-transcriptional regulation occurs by modulation of TNF-alpha mRNA stability via the binding of tristetraprolin (TTP) to the adenosine/uridine-rich elements found in the 3'-untranslated region of the TNF-alpha transcript...
  29. pmc TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements
    Tobias M Franks
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 21:719-35. 2007
    ..Here we present evidence that in human cells the proteins Tristetraprolin (TTP) and BRF-1 deliver ARE-mRNAs to processing bodies (PBs), cytoplasmic assemblies of mRNAs, and associated ..
  30. ncbi Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
    Kristen M Deleault
    Department of Medicine, Dartmouth Medical School, 1 Medical Center Dr, Lebanon, NH 03756, USA
    Mol Immunol 45:13-24. 2008
    ..One of the best characterized trans-acting proteins is Tristetraprolin (TTP), which regulates TNF-alpha message stability...
  31. pmc Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation
    Khadija Essafi-Benkhadir
    Unité Mixte de Recherche Centre National de la Recherche Scientifique 6543, University of Nice Sophia Antipolis, Equipe labellisée Ligue Nationale Contre le Cancer, 06189 Nice cedex, France
    Mol Biol Cell 18:4648-58. 2007
    ..In this complex phenomenon, tristetraprolin (TTP), an adenylate and uridylate-rich element-associated protein that binds to VEGF mRNA 3'-untranslated ..
  32. pmc Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells
    Nagaraja Sethuraman Balakathiresan
    Departments of Health Systems, Risk, and Contingency Management, Graduate School of Nursing, Uniformed Services Univ of the Health Sciences, Bethesda, MD 20814, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1012-8. 2009
    ..posttranscriptional regulation of proinflammatory genes upon binding to ARE-binding proteins including Tristetraprolin (TTP)...
  33. doi Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer
    Hyun Hee Lee
    Department of Biological Sciences, University of Ulsan, Ulsan 682 060, Korea
    Int J Cancer 126:1817-27. 2010
    b>Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability...
  34. pmc RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling
    Jian Liang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, USA
    J Biol Chem 284:29383-90. 2009
    b>Tristetraprolin (TTP) is a CCCH zinc finger-containing protein that destabilizes mRNA by binding to an AU-rich element...
  35. doi Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia
    Tae Woo Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 333, Republic of Korea
    Biochem Biophys Res Commun 391:963-8. 2010
    ..Here, we show that tristetraprolin (TTP) protein, of which the mRNA expression level is downregulated in most of hepatocellular carcinoma ..
  36. pmc The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase
    Sandhya Sanduja
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC 29203, USA
    Aging (Albany NY) 1:803-17. 2009
    The RNA-binding protein tristetraprolin (TTP) regulates expression of many cancer-associated and proinflammatory factors through binding AU-rich elements (ARE) in the 3'-untranslated region (3'UTR) and facilitating rapid mRNA decay...
  37. doi ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production
    Christine Hacker
    Institute of Physiology, Charite University Medicine Berlin, Arnimallee 22, D 14195, Berlin, Germany
    Growth Factors 28:178-90. 2010
    ..Thus, we analyzed a potential role of the ZFP36/tristetraprolin family of zinc finger proteins, which are targets of these factors, but also regulate their production, in ..
  38. pmc The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes
    N Al-Souhibani
    Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Oncogene 29:4205-15. 2010
    b>Tristetraprolin (TTP or ZFP36) is a tandem CCCH zinc-finger RNA-binding protein that regulates the stability of certain AU-rich element (ARE) mRNAs...
  39. pmc Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment
    Sandra L Clement
    Molecular, Cellular, and Development Biology, Universit of Colorado, Boulder, Colorado 80309, USA
    Mol Cell Biol 31:256-66. 2011
    ..Here we show that a key destabilizing AUBP, tristetraprolin (TTP), is repressed by the p38 mitogen-activated protein kinase (MAPK)-activated kinase MK2 due to the ..
  40. pmc The roles of TTP and BRF proteins in regulated mRNA decay
    Sandhya Sanduja
    Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC, USA
    Wiley Interdiscip Rev RNA 2:42-57. 2011
    ..The TIS11 family of RNA-binding proteins, composed of tristetraprolin (TTP) and butyrate response factors 1 and 2 (BRF-1 and -2), plays a critical role in regulating the ..
  41. doi Constitutive ERK activity induces downregulation of tristetraprolin, a major protein controlling interleukin8/CXCL8 mRNA stability in melanoma cells
    Christine Bourcier
    University Nice Sophia Antipolis, Institute of Signalling, Developmental Biology and Cancer Research, UMR Centre National de la Recherche Scientifique, Nice, France
    Am J Physiol Cell Physiol 301:C609-18. 2011
    ..CXCL8 mRNA contains multiples AU-rich sequences (AREs) that modulate mRNA stability through the binding of tristetraprolin (TTP). Melanoma cell lines express very low TTP levels...
  42. pmc Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma
    Elizabeth Van Tubergen
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Cancer 117:2677-89. 2011
    ..Targeting proteins, such as tristetraprolin (TTP), that regulate multiple inflammatory cytokines may inhibit the progression of HNSCC...
  43. ncbi Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer
    Hee Jeong Cha
    Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
    Hepatogastroenterology 58:790-5. 2011
    ..The aim is to investigate the effects of tristetraprolin, an AU-rich element-binding protein on the expression of VEGF and COX-2 in human colon cancer cells.
  44. pmc Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28
    Chae Won Kim
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea
    Nucleic Acids Res 40:3856-69. 2012
    b>Tristetraprolin (TTP) is a AU-rich element (ARE) binding protein and exhibits suppressive effects on cell growth through down-regulation of ARE-containing oncogenes...
  45. pmc Expression of proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is post-transcriptionally regulated by tristetraprolin in cancer cells
    Hong Kyeung Kim
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea
    J Biol Chem 287:28770-8. 2012
    ..Here, we demonstrate that tristetraprolin (TTP) plays a critical role in the regulation of Pim-1 mRNA stability...
  46. ncbi Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail
    W S Lai
    Office of Clinical Research and Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:23144-54. 2001
    ..In the case of one member of this family, tristetraprolin (TTP), absence of the protein in knockout mice leads to stabilization of two mRNAs containing AREs of this ..
  47. ncbi Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay
    Rachel L Ogilvie
    Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis 55455, USA
    J Immunol 174:953-61. 2005
    ..We hypothesized that the ARE-binding protein tristetraprolin (TTP) regulates T lymphocyte IL-2 mRNA decay by interacting with the IL-2 ARE and targeting the transcript ..
  48. pmc Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1
    Jens Lykke-Andersen
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 19:351-61. 2005
    ..all three of these mRNA decay processes, as well as 5'-to-3' exonucleolytic decay, associate with the protein tristetraprolin (TTP) and its homolog BRF-1, which bind AREs and activate mRNA decay...
  49. ncbi Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro
    G A Taylor
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:13341-7. 1995
    b>Tristetraprolin (TTP) is a potential transcription factor that contains three PPPPG repeats and two putative CCCH zinc fingers...
  50. ncbi A human putative lymphocyte G0/G1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor
    S P Heximer
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    DNA Cell Biol 12:73-88. 1993
    ..Group 1 contains G0S24 and the rat and mouse TIS11 genes (also known as TTP, Nup475, and Zfp36). Members of this group have three tetraproline repeats...
  51. ncbi Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs
    Wi S Lai
    Office of Clinical Research and the Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:9606-13. 2002
    b>Tristetraprolin (TTP), the prototype of a small family of CCCH tandem zinc finger (TZF) domain proteins, is a physiological stimulator of instability of the mRNAs encoding tumor necrosis factor-alpha and granulocyte/macrophage colony-..
  52. ncbi Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms
    Barbra A Johnson
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:18029-36. 2002
    The immediate early gene tristetraprolin (TTP) is induced transiently in many cell types by numerous extracellular stimuli...
  53. ncbi Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates
    Perry J Blackshear
    Laboratory of Signal Transduction, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:19947-55. 2003
    b>Tristetraprolin (TTP) and its two known mammalian family members are tandem CCCH zinc finger proteins that can bind to AU-rich elements (AREs) in cellular mRNAs and destabilize those transcripts, apparently by initiating their ..
  54. ncbi Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins
    Perry J Blackshear
    Office of Clinical Research and Laboratory of Signal Transduction, A2 05 National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Prog Nucleic Acid Res Mol Biol 75:43-68. 2003
    The three known mammalian CCCH tandem zinc finger proteins of the tristetraprolin (TTP) class have recently been demonstrated to be mRNA-binding proteins...
  55. ncbi Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression
    Jean Claude Twizere
    Biologie Cellulaire et Moleculaire, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    J Natl Cancer Inst 95:1846-59. 2003
    ..e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax...
  56. ncbi Direct association of tristetraprolin with the nucleoporin CAN/Nup214
    Julie A Carman
    Lawrenceville Discovery Biology, Bristol Myers Squibb, Princeton, NJ 08543, USA
    Biochem Biophys Res Commun 315:445-9. 2004
    b>Tristetraprolin (TTP) is a widely expressed, zinc finger-containing protein that has been implicated in the regulation of TNFalpha production in mice...
  57. pmc Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications
    Heping Cao
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 43:13724-38. 2004
    b>Tristetraprolin (TTP) is a hyperphosphorylated protein that destabilizes mRNA by binding to an AU-rich element (ARE). Mice deficient in TTP develop a severe inflammatory syndrome...
  58. ncbi Comparative expression of tristetraprolin (TTP) family member transcripts in normal human tissues and cancer cell lines
    Danielle M Carrick
    The Office of Clinical Research, National Institute of Environmental Health Sciences, NIEHS MD A2 05, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Arch Biochem Biophys 462:278-85. 2007
    The tristetraprolin (TTP) family of tandem zinc finger proteins comprises three members in man and most other mammals, with a fourth expressed in rodents...
  59. pmc Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation
    Jillian Emmons
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    RNA 14:888-902. 2008
    ..b>Tristetraprolin is an AU-rich element mRNA-binding protein that has been shown to regulate the stability of a number of ..
  60. pmc Tristetraprolin mediates interferon-gamma mRNA decay
    Rachel L Ogilvie
    Centers for Infectious Diseases and Microbiology Translational Research and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 284:11216-23. 2009
    b>Tristetraprolin (TTP) regulates expression at the level of mRNA decay of several cytokines, including the T cell-specific cytokine, interleukin-2...
  61. pmc Stability of the LATS2 tumor suppressor gene is regulated by tristetraprolin
    Hyun Hee Lee
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Korea
    J Biol Chem 285:17329-37. 2010
    ..Here, we investigated the post-transcriptional regulation of LATS2 expression by tristetraprolin (TTP)...
  62. doi Tristetraprolin controls the stability of cIAP2 mRNA through binding to the 3'UTR of cIAP2 mRNA
    Chae Won Kim
    Department of Biological Sciences, University of Ulsan, Ulsan 680 749, Republic of Korea
    Biochem Biophys Res Commun 400:46-52. 2010
    ..Here, we investigated the post-transcriptional regulation of cIAP2 expression by tristetraprolin (TTP)...
  63. pmc Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells
    Sandrine Chamboredon
    Institut National de la Sante et de la Recherche Medicale, Unité 1036 Grenoble, France
    Mol Biol Cell 22:3366-78. 2011
    ..protein levels rapidly peak after 3 h and then slowly decay; 2) silencing the mRNA-destabilizing protein tristetraprolin (TTP) in ECs reverses hypoxia-induced down-regulation of HIF-1α mRNA; 3) the decrease in the half-life of ..
  64. pmc Tristetraprolin: roles in cancer and senescence
    Christina R Ross
    Department of Biochemistry and Molecular Biology and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ageing Res Rev 11:473-84. 2012
    ..this review, we discuss evidence showing how suppressed expression and/or activity of the ARE-binding protein tristetraprolin (TTP) can contribute to these processes...
  65. ncbi Transcriptional regulation of tristetraprolin by transforming growth factor-beta in human T cells
    Kenji Ogawa
    Department of Medical and Molecular Genetics, Walther Oncology Center, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:30373-81. 2003
    ..b>Tristetraprolin (TTP), a protein involved in the degradation of tumor necrosis factor-alpha (TNF-alpha) mRNA, was found to be ..
  66. ncbi Analysis of the function, expression, and subcellular distribution of human tristetraprolin
    Seth A Brooks
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Arthritis Rheum 46:1362-70. 2002
    The zinc-finger protein tristetraprolin (TTP) has been demonstrated to regulate tumor necrosis factor alpha (TNFalpha) messenger RNA (mRNA) instability in murine macrophages...
  67. ncbi [Evaluation of antibiotics used for enterohemorrhagic Escherichia coli O157 enteritis--effect of various antibiotics on extracellular release of verotoxin]
    T Ito
    Department of Bacteriology, Faculty of Medicine, Juntendo University
    Kansenshogaku Zasshi 71:130-5. 1997
    ..TC) are the safe antibiotics not causing the release of verotoxin from the cells and thus preventing development of hemolytic uremic syndrome (HUS) or thrombotic thrombocytopenic purpra (TTP), the important sequelae of the enteritis.
  68. ncbi Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome
    Maria Goretti Polito
    Universidade Federal de Sao Paulo, Brazil
    J Bras Nefrol 32:303-15. 2010
    ..Two typical phenotypes of TMAs are hemolytic- uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Other disorders occasionally present with similar manifestations...
  69. pmc Effects of pyrimidines on the guinea-pig coronary vasculature
    A J Vials
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 110:1091-7. 1993
    1. The effects of the pyrimidines, uridine 5'-triphosphate (UTP), thymidine 5'-triphosphate (TTP) and cytidine 5'-triphosphate (CTP), were examined in the guinea-pig coronary bed, by use of a Langendorff technique...
  70. ncbi Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/ thrombotic thrombocytopenic purpura (TTP): can we differentiate one from the other?
    Yugo Shibagaki
    Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hypertens Res 28:89-95. 2005
    ..hypertension is sometimes associated with hemolytic uremic syndrome (HUS)/thrombotic thrombocytopenic purpura (TTP)...
  71. doi Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials
    Mini Michael
    Renal Section Department of Pediatrics, Texas Children s Hospital Baylor College of Medicine, Houston, TX, USA
    Am J Kidney Dis 53:259-72. 2009
    Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are related conditions with similar clinical features of variable severity...
  72. ncbi High-dose plasma infusion versus plasma exchange as early treatment of thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome
    Paul Coppo
    Laboratoire Hématopoïèse et Cellules souches, Institut Gustave Roussy, Villejuif, France
    Medicine (Baltimore) 82:27-38. 2003
    Thrombotic thrombocytopenic purpura and adult hemolytic-uremic syndrome (TTP/HUS) have a substantial mortality rate even with currently available treatments...
  73. ncbi Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention
    C L Bennett
    Institute for Health Services Research and Policy Studies, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Ill, USA
    Arch Intern Med 159:2524-8. 1999
    One of the most unusual causes of thrombotic thrombocytopenic purpura (TTP), a life-threatening disease, is ticlopidine hydrochloride, an antiplatelet agent used to prevent strokes in high-risk populations or following coronary artery ..
  74. doi Plasma exchange therapy for thrombotic thrombocytopenic purpura in pediatric patients with liver transplantation
    C H Lee
    Division of Nephrology, Liver Transplant Program, Chang Gung Memorial Hosptial Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Transplant Proc 40:2554-6. 2008
    Sporadic cases of thrombotic thrombocytopenic purpura (TTP) have been reported in bone marrow and solid organ transplant patients receiving cyclosporine (CsA)...
  75. doi Simultaneous dynamic blood oxygen level-dependent magnetic resonance imaging of foot and calf muscles: aging effects at ischemia and postocclusive hyperemia in healthy volunteers
    Sebastian Kos
    Institute of Radiology, Divisions of Interventional Radiology, University of Basel Hospital, Basel, Switzerland
    Invest Radiol 44:741-7. 2009
    ....
  76. ncbi [Report of questionnaire about enterohemorrhagic Escherichia coli cases caused in the area including Sakai City in 1996]
    M Yoh
    Department of Bacterial Infections, Osaka University
    Kansenshogaku Zasshi 71:1144-54. 1997
    ..2) Higher HUS/TTP complication was accompanied with patients complained symptoms of fever, bloody diarrhea, and general fatigue...
  77. ncbi Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting
    S R Steinhubl
    Department of Cardiology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Tex 78236 5300, USA
    JAMA 281:806-10. 1999
    Thrombotic thrombocytopenic purpura (TTP) is a rare and often fatal disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, mental status changes, and renal dysfunction...
  78. ncbi Tako-tsubo-like left ventricular dysfunction: clinical presentation, instrumental findings, additional cardiac and non-cardiac diseases and potential pathomechanisms
    C Stollberger
    Krankenanstalt Rudolfstiftung, Medizinische Abteilung, Wien, Osterreich
    Minerva Cardioangiol 53:139-45. 2005
    Tako-tsubo-like left ventricular dysfunction phenomenon (TTP) has primarily been described in Japan and is characterized by transient left ventricular apical ballooning in the absence of coronary artery disease, associated with chest ..
  79. ncbi Effect of plasma exchange on cytokines measured by multianalyte bead array in thrombotic thrombocytopenic purpura
    Sherry Shariatmadar
    Department of Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Hematol 79:83-8. 2005
    The serum cytokine profile in thrombotic thrombocytopenic purpura (TTP) has not been extensively characterized...
  80. pmc Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS): a 24-year clinical experience with 178 patients
    Mark Levandovsky
    Division of Hematology and Oncology, UC Davis School of Medicine, Sacramento, CA, USA
    J Hematol Oncol 1:23. 2008
    Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome (TTP-HUS) are related and uncommon disorders with a high fatality and complication rate if untreated...
  81. ncbi Posttransplantation thrombotic thrombocytopenic purpura: a single-center experience and a contemporary review
    Michelle A Elliott
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:421-30. 2003
    To assess the activity of von Willebrand factor-cleaving protease (vWF-CP) in patients with thrombotic thrombocytopenic purpura (TTP) complicating bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT).
  82. ncbi Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)
    Christoph Licht
    Department of Pediatric Nephrology and Pediatric Hematology Oncology, University Children s Hospital of Cologne, Cologne, Germany
    Kidney Int 66:955-8. 2004
    Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) are now considered to be variants of one single syndrome called thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)...
  83. ncbi Socioeconomic factors, medicolegal issues, and trauma patient transfer trends: Is there a connection?
    Thomas J Esposito
    Division of Trauma Critical Care and Burns, Department of Surgery, Loyola University Stritch School of Medicine, Loyola University Burn and Shock Trauma Institute, Maywood, Illinois, USA
    J Trauma 61:1380-6; discussion 1386-8. 2006
    ..These may have little to do with the actual clinical need. This study seeks to verify whether a change in the profile of trauma transfers has occurred and to characterize the nature of any changes...
  84. ncbi Therapeutic plasma exchange for the treatment of thrombotic thrombocytopenic purpura: a retrospective multicenter study
    Fevzi Altuntas
    Erciyes University, Department of Hematology and Hemapheresis Unit, 38039 Kayseri, Turkey
    Transfus Apher Sci 36:57-67. 2007
    Thrombotic thrombocytopenic purpura (TTP) is a rare disease that is fatal if it is not treated. Therapeutic plasma exchange (TPE) has resulted in excellent remission and survival rates in TTP patients.
  85. pmc Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project
    Charles L Bennett
    VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 50:1138-43. 2007
    We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP).
  86. ncbi Twice-daily plasma exchange for patients with refractory thrombotic thrombocytopenic purpura: the experience of the Oklahoma Registry, 1989 through 2006
    Loan Nguyen
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Transfusion 48:349-57. 2008
    Twice-daily plasma exchange has been used for patients with thrombotic thrombocytopenic purpura (TTP) who are unresponsive to treatment with daily plasma exchange for many years but with no clear evidence of effectiveness.
  87. ncbi Identification of four CCCH zinc finger proteins in Xenopus, including a novel vertebrate protein with four zinc fingers and severely restricted expression
    J De
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Gene 228:133-45. 1999
    b>Tristetraprolin (TTP), the prototype of a class of CCCH zinc finger proteins, is a phosphoprotein that is rapidly and transiently induced by growth factors and serum in fibroblasts...
  88. doi Lupus nephritis combined with renal injury due to thrombotic thrombocytopaenic purpura-haemolytic uraemic syndrome
    Feng Yu
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University and Key Laboratory of Renal disease, Ministry of Health of China, Beijing 100034, People s Republic of China
    Nephrol Dial Transplant 25:145-52. 2010
    Thrombotic thrombocytopaenic purpura-haemolytic uraemic syndrome (TTP-HUS) in SLE was reported mainly in isolated case reports...
  89. ncbi Predicting response to plasma exchange in patients with thrombotic thrombocytopenic purpura with measurement of vWF-cleaving protease activity
    Yoshitaka Mori
    Mie Red Cross Blood Center, Tsu City, Japan
    Transfusion 42:572-80. 2002
    ..vWF-cleaving protease (vWF-CPase) activity was recently found in patients with thrombotic thrombocytopenic purpura (TTP)...
  90. ncbi Therapeutic plasma exchange plus corticosteroid for the treatment of the thrombotic thrombocytopenic purpura: a single institutional experience in the southern Marmara region of Turkey
    Fahir Ozkalemkas
    Department of Hematology, Uludag University, 16059 Gorukle, Bursa, Turkey
    Transfus Apher Sci 36:109-15. 2007
    Thrombotic thrombocytopenic purpura (TTP) is a classic, but not a common disorder of hematology. Plasma exchange (PE) was shown to nearly reverse its 90% mortality rate...
  91. ncbi Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports
    Karen K Swisher
    Hematology Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Haematologica 92:936-43. 2007
    The thrombotic thrombocytopenic purpura-hemolytic uremic syndromes (TTP-HUS) have diverse etiologies, clinical manifestations, and risk factors, but the events that may trigger acute episodes are often unclear...
  92. pmc Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes
    Deirdra R Terrell
    Department of Biostatistics and Epidemiology, College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126 0901, USA
    Am J Hematol 85:844-7. 2010
    Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) represent multiple disorders with diverse etiologies...
  93. ncbi Thrombotic thrombocytopenic purpura
    B Lammle
    Department of Hematology and Central Hematology Laboratory, Inselspital, University Hospital, Bern, Switzerland
    J Thromb Haemost 3:1663-75. 2005
    This overview summarizes the history of thrombotic thrombocytopenic purpura (TTP) from its initial recognition in 1924 as a most often fatal disease to the discovery in 1997 of ADAMTS-13 deficiency as a major risk factor for acute ..
  94. doi Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry
    James N George
    College of Public Health, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    J Clin Apher 23:129-37. 2008
    The Oklahoma TTP-HUS Registry provides a complete community perspective of thrombotic thrombocytopenic purpura (TTP)...
  95. doi Value of ADAMTS13 activity and inhibitor in the postmortem diagnosis of thrombotic thrombocytopenic purpura
    Denis M Dwyre
    Department of Pathology, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Apher 24:106-10. 2009
    Thrombotic thrombocytopenic purpura (TTP) is a clinical diagnosis that can be difficult to establish in severely ill patients. We report a case of fulminant TTP in a woman who died before receiving plasma exchange...
  96. pmc Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA
    Breeana C Grogan
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205 2185, United States
    Biochemistry 50:618-27. 2011
    ..these divergent findings in yeast and human cells, we have investigated how these drugs perturb cellular dUTP and TTP pool levels and the relative abilities of three human DNA glycosylases (hUNG2, hSMUG1, and hTDG) to excise various ..
  97. ncbi Disseminated malignancy misdiagnosed as thrombotic thrombocytopenic purpura: A report of 10 patients and a systematic review of published cases
    Kristin K Francis
    Hematology Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Room CHB 358, PO Box 26901, Oklahoma City, Oklahoma 73190, USA
    Oncologist 12:11-9. 2007
    ..microangiopathic hemolytic anemia and thrombocytopenia may be misdiagnosed as thrombotic thrombocytopenic purpura (TTP), resulting in inappropriate plasma exchange treatment, a procedure with major risk, and delay of appropriate ..
  98. doi Frequency and significance of HIV infection among patients diagnosed with thrombotic thrombocytopenic purpura
    Melody Benjamin
    Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73126 0901, USA
    Clin Infect Dis 48:1129-37. 2009
    Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP.
  99. pmc Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85
    Vishram P Kedar
    The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 5:e9588. 2010
    b>Tristetraprolin (TTP) is the prototype member of a family of CCCH tandem zinc finger proteins and is considered to be an anti-inflammatory protein in mammals...
  100. ncbi The substrate range of tripeptidyl-peptidase I
    F Bernardini
    Department of Histopathology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Eur J Paediatr Neurol 5:69-72. 2001
    ..Digestion of a range of peptides of different size by TTP-I suggests that the enzyme will degrade small peptides with an extended N-terminal domain but not structured ..
  101. doi MRI perfusion maps in acute stroke validated with 15O-water positron emission tomography
    Olivier Zaro-Weber
    Department of Neurology, University of Cologne, Max Planck Institute for Neurological Research, Gleueler Str 50, 50931 Cologne, Germany
    Stroke 41:443-9. 2010
    ..We evaluated maps of cerebral blood flow (CBF), cerebral blood volume, mean transit time, and time to peak (TTP) in acute stroke by comparison with positron emission tomography.

Research Grants65

  1. "Development of a Laboratory Test for TTP"
    Christopher Hillyer; Fiscal Year: 2003
    ..to develop a laboratory test for the diagnosis and monitoring of patients with thrombotic thrombocytopenic purpura (TTP). As there is no reliable, controlled laboratory test, TTP must be diagnosed on clinical grounds alone...
  2. X Long Zheng; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Thrombotic thrombocytopenic purpura (TTP) is a fatal syndrome. Acquired TTP is mainly caused by autoantibodies that inhibit ADAMTS13 enzyme...
  3. Ph 3 of Cyclosporine or Corticosteroids Adjunct to Plasma Exhcange in Tx of TTP
    Haifeng M Wu; Fiscal Year: 2013
    ..OSU) to build a translational research program in the orphan disease thrombotic thrombocytopenic purpura (TTP)...
  4. VON WILLEBRAND FACTOR AND THE PATHOPHYSIOLOGY OF TTP
    Joel Moake; Fiscal Year: 1990
    ..clinical and basic research work on the paradigm arterial thrombotic disease, thrombotic thrombocytopenic purpura (TTP)...
  5. Timothy A Springer; Fiscal Year: 2015
    ..Inherited or acquired deficiency of ADAMTS13 causes life-threatening thrombotic thrombocytopenic purpura (TTP)...
  6. David Ginsburg; Fiscal Year: 2016
    ..disorders of VWF and FVIII were identified: ADAMTS13 as the cause of familial thrombotic thrombocytopenic purpura (TTP) and MCFD2/LMAN1 as the cause of combined deficiency for factors V and VIII...
  7. Xiaoping Du; Fiscal Year: 2016
    ..Under certain pathological conditions such as thrombotic thrombocytopenic purpura (TTP), binding of GPIb-IX to circulating ultra-large VWF multimers induces microthrombosis and development of ..
  8. Von Willebrand Factor Multimer Assembly and Structure
    J Evan Sadler; Fiscal Year: 2012
    ..cleaves VWF multimers at sites of thrombosis, and ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura (TTP)...
  9. Regulation of von Willebrand Factor Reactivity
    JOSE ARON LOPEZ; Fiscal Year: 2012
    Thrombotic thrombocytopenic purpura (TTP) is a catastrophic and potentially fatal microvascular thrombotic disorder associated with congenital or acquired deficiency of the plasma metalloprotease ADAMTS-13...
  10. BIOMECHANICS OF UNFOLDING THE A2 DOMAIN OF VON WILLEBRAND FACTOR
    Jin Yu Shao; Fiscal Year: 2012
    ..Excessive VWF cleavage results in von Willebrand disease (VWD), whereas insufficient VWF cleavage results in thrombotic thrombocytopenic purpura (TTP), a disease characterized by microvascular thrombosis.
  11. Functional analysis of ADAMTS13
    David G Motto; Fiscal Year: 2010
    ..newly described metalloprotease ADAMTS13 play in pathogenesis of the disease thrombotic thrombocytopenic purpura (TTP). ADAMTS13 deficiency in humans causes TTP...
  12. Mechanical Regulation of Binding and Cleavage of VWF by ADAMTS-13
    Cheng Zhu; Fiscal Year: 2012
    ..new therapeutic approaches to inhibiting pathological platelet adhesion during thrombosis and/or intervention to thrombotic thrombocytopenic purpura (TTP) and/or the bleeding disorder von Willebrand diseases (VWD).
  13. David G Motto; Fiscal Year: 2015
    ..research program investigating pathophysiology of the human thrombotic disease thrombotic thrombocytopenic purpura (TTP). The PI and co-PI are both relatively new Assistant Professors in Hematology/Oncology at the University of Iowa...
  14. PLATELET AGGLUTINATION IN THROMBOTIC MICROANGIOPATHY
    ERIC LIAN; Fiscal Year: 1993
    ..proteins p37 (PAP p37) and p58 (PAP p58) out of the plasmas from two different patients with TTP, which are thought to cause the thrombotic lesions in the small vessels in some TTP patients...
  15. MECHANISMS OF ENDOTHELIAL CELL INJURY IN TTP/HUS
    Jerome Gottschall; Fiscal Year: 1999
    Thrombotic thrombocytopenic purpura (TTP) is a multi-system disorder characterized by micro angiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, and less commonly, fever and renal abnormalities...
  16. ENDOTHELIAL GB3 SPECIES INVOLVED IN HUS PATHOGENESIS
    DAVID NEWBURG; Fiscal Year: 2003
    ..injury are life-threatening complications of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura (HUS/TTP). Survivors of HUS/TTP sometimes suffer irreversible damage...
  17. Judith A James; Fiscal Year: 2016
    ..The pilot project uses complimentary methods to address roles of elevated interferon activity in patients with TTP and a novel animal model of thrombocytopenia...
  18. MOLECULAR GENETICS OF COAGULATION DISORDERS
    David Ginsburg; Fiscal Year: 2013
    ..to identify additional thrombosis modifiers, as well as modifier genes for thrombotic thrombocytopenic purpura (TTP);(2) continue to explore the critical factors that limit factor VIII expression...
  19. Transfusion Medicine/Hemostasis Core Clinical Center
    Thomas L Ortel; Fiscal Year: 2012
    ..In contrast, many hemostatic disorders, such as thrombotic thrombocytopenic purpura (TTP) and hemophilia A patients with inhibitors, are relatively rare, making it difficult to answer important clinical ..
  20. MGH Transfusion Medicine and Hemostasis Network Clinical Core Center
    David J Kuter; Fiscal Year: 2012
    ..as well as the optimal therapy for immune thrombocytopenic purpura (IIP) and thrombotic thrombocytopenic purpura (TTP) are not understood...
  21. Forecasters of futute and progressive CDK in patients with microvascular glomerul
    Haifeng M Wu; Fiscal Year: 2013
    ..injury due to autoimmune disease (lupus nephritis, SLE), thrombotic disease (thrombotic thrombocytopenic purpura, TTP), and metabolic disease (diabetes mellitus, DM)...
  22. Transfusion Medicine/Hemostasis Clinical Research Network
    Keith R McCrae; Fiscal Year: 2012
    ..for hemostatic disorders such as immune thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP), as well as new blood products such as platelets and platelet substitutes, thrombopoetin analogues and cytokines...
  23. Study of TTP: Incidence Rates and Risk Factors
    Charles Bennett; Fiscal Year: 2005
    Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by a pentad of symptoms including microangiopathic hemolytic anemia (MAHA), thrombocytopenia, neurologic symptoms, fever, and renal dysfunction...
  24. A platelet ligand mimetic for neurothrombotic disorders
    Catherine Woods; Fiscal Year: 2006
    ..cerebral hemorrhage and cerebral thrombotic complications in disorders such as thrombotic thrombocytopenic purpura (TTP), cerebral malaria, meningitis vascular dementia and Alzheimer's Disease (AD) where localized recruitment of ..
  25. TTP PATHOGENESIS IN MODEL SYSTEMS IN VITRO AND IN VIVO
    David Acheson; Fiscal Year: 1999
    This research proposal is a response to NHLBI RFA HL-95-007 (Thrombotic Thrombocytopenic Purpura (TTP) and HIV)...
  26. PHYSICAL FORCES EFFECTS ON PLATELETS
    J Hellums; Fiscal Year: 2000
    ..on platelets from normal subjects, as well as on platelets from patients with thrombotic thrombocytopenic purpura (TTP) and other disorders...
  27. THE ENDOTHELIAL CELL IN PATHOGENESIS OF TTP
    Jeffrey Laurence; Fiscal Year: 2004
    ..plays a key role in the pathophysiology of idiopathic and HIV-associated thrombotic thrombocytopenic purpura (TTP)...
  28. Fluorescence Fluctuation Spectroscopy for von Willebrand Factor Multimer Analysis
    Michael J Levene; Fiscal Year: 2010
    ..and monitoring, for elucidating specifics about the pathogenetic mechanism of thrombotic thrombocytopenia purpura (TTP), and as a new tool for assessment of coagulation or bleeding risk in a variety of common systemic conditions...
  29. FASEB SRC on Proteases in Hemostasis and Vascular Biology
    JAMES ANDREW HUNTINGTON; Fiscal Year: 2013
    ..and regulation;2) Platelet adhesion;3) Fibrin(ogen)(olysis);4) Platelet signaling;5) von Willebrand Factor, TTP and proteases;6) Proteases and inhibitors in host defense;7) The O'Mics: Genomics/proteomics/degradomics/..
  30. FASL IN PREECLAMPSIA AND IMMUNOTOLERANCE TO THE FETUS
    Scott Kauma; Fiscal Year: 2002
    ..Thrombotic Thrombocytopenia Purpura (TTP) and Hemolytic Uremic Syndrome (HUS), two diseases that are clinically similar to preeclampsia, are caused by Fas/..
  31. Keith L Kirkwood; Fiscal Year: 2015
    ..b>Tristetraprolin (TTP) is a zinc finger protein that binds to the ARE of cytokine mRNAs and enhances degradation of the mRNA...
  32. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    Thrombotic thrombocytopenic purpura (TTP) is a fatal disorder that is characterized by the presence of systemic hyaline thrombi in the arterioles and capillaries. The incidence is estimated to be 4-30 cases/million/year...
  33. Intensive Smoking Cessation Invervention for Head and Neck Cancer Patients
    JANICE ANITA BLALOCK; Fiscal Year: 2012
    ..D. Anderson Cancer Center (MDACC) Tobacco Treatment Program (TTP) and other studies suggest that 28 percent to 46 percent of patients continue to smoke...
  34. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..Thus, folate deficiency decreases TTP, increases dUTP, and increases uracil incorporation into DNA...
  35. Robert Paine; Fiscal Year: 2016
    ..We also have evidence that a zinc finger protein, ZFP36 or tristetraprolin (TTP), may contribute to GM-CSF mRNA degradation...
  36. Elizabeth E Hatch; Fiscal Year: 2014
    ..by investigator): We propose to conduct a prospective cohort study of risk factors for delayed time to pregnancy (TTP) among Danish couples...
  37. Small heat shock proteins in smooth muscle plasticity
    William T Gerthoffer; Fiscal Year: 2013
    ..suggest a convergence of p38MAPK/MK2 signaling and miRNA-induced silencing at the level of HSP27 and tristetraprolin. We are proposing a substantial shift in focus of the project to test the novel idea that phosphorylation of ..
  38. Bonnie B Blomberg; Fiscal Year: 2014
    ..g. tristetraprolin, TTP) binding to the 3'untranslated region (UTR);c) establish mechanisms of TTP regulation including ..
  39. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..Conserved overlapping sites for miR-466L and for the RNA binding proteins HuR and TTP are present in the 3'UTR...
  40. Post-Transcriptional Regulation in Colorectal Cancer
    DAN ALAN DIXON; Fiscal Year: 2013
    ..post-transcriptional regulation are the mRNA stability factor Hu antigen R (HuR) and the mRNA decay factor tristetraprolin (TTP)...
  41. Jianguo Liu; Fiscal Year: 2016
    ..Recently, we have found that the expression of tristetraprolin (TTP), a zinc finger protein promoting mRNA decay of many target genes, is markedly reduced in breast tumors ..
  42. CALEB BENJAMIN KALLEN; Fiscal Year: 2016
    ..Our work may identify ZFP36 as a new therapeutic target for important medical conditions exacerbated by obesity and inflammation including atherosclerosis and diabetes. ..
  43. Determinants of Efficacy to the Akt Inhibitor Perifosine in Colorectal Cancer
    Cathy Eng; Fiscal Year: 2012
    ..Striking phase II data of perifosine capecitabine demonstrated a 2- to 3-fold superior time to progression (TTP), response, and overall survival (OS) in metastatic colorectal patients (MCRC)...
  44. Post-transcriptional control of inflammatory gene expression
    Thomas A Hamilton; Fiscal Year: 2013
    ..involves AUUUA-containing AU rich sequence elements (AREs) that are recognized by the ARE binding protein Tristetraprolin (TTP)...
  45. SILVIA BEATRIZ RAMOS; Fiscal Year: 2016
    ..In aim 1, the PI wll selectively overexpress and down-regulate each of the ZFP36 proteins (TTP, ZFP36L1 and ZFP36L2) in human cell lines to determine whether LIF mRNA can be destabilized by these proteins...
  46. Mechanisms of normal and abnormal platelet homeostasis
    Joel S Bennett; Fiscal Year: 2010
    ..of immune-mediated thrombocytopenias" studies the nature of autoantibody responses in patients with ITP, HIT, and TTP. Project 3, entitled "Clinical aspects of aspirin and clopidogrel resistance", addresses the stability, specificity ..
  47. Ionizing Radiation Control of Inflammatory Cytokine mRNA Stability and Expression
    Robert Schneider; Fiscal Year: 2013
    ..wild type and AUF1-/- macrophages, and determine the extent to which other ARE-binding proteins such as TTP, KSRP and stabilizing protein HuR are involved in IR-mediated stabilization of inflammatory cytokine ARE-mRNAs...
  48. Mitochondrial Toxicity of Antiviral Nucleosides
    Edward E McKee; Fiscal Year: 2010
    ..We have recently demonstrated that AZT significantly decreases the TTP pool in the perfused heart...
  49. Lauren A Wise; Fiscal Year: 2014
    ..We propose to conduct an internet-based feasibility study of risk factors for delayed time-to-pregnancy (TTP), a sensitive indicator of a couple's fertility...
  50. FAOUD TERRENCE ISHMAEL; Fiscal Year: 2014
    ..Two RNA binding proteins (RBPs), TTP and HuR appear to play central roles in the inflammatory response: HuR increases mRNA stability and promotes ..
  51. Functions of Tocopherol Transfer Protein
    Danny Manor; Fiscal Year: 2012
    ..The hepatic alpha tocopherol transfer protein (TTP) is a critical regulator of vitamin E status;humans carrying mutated TTP alleles develop severe vitamin E ..
  52. Novel HBV Therapeutic with Potential for Treatment of Drug-Resistant Infection
    Andrea Cuconati; Fiscal Year: 2013
    ..Concurrent with the above aims, we will 7) attempt to identify the precise molecular target of the TTPs through affinity studies. At the end of Phase 2, a TTP compound will be ready for IND filing and eventual clinical trials.
  53. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    CONSTANTINOS THASOS SOFOCLEOUS; Fiscal Year: 2011
    ..that when tissue adherent to the electrode was positive for Ki67 a higher LTP rate and shorter time to progression (TTP) was observed...
  54. The role of tristetraprolin in head and neck cancer progression
    ELIZABETH ANNE VAN TUBERGEN; Fiscal Year: 2012
    ..The overall objective of this application is to delineate the role of tristetraprolin (TTP), an RNA-binding protein, in head and neck cancer (HNSCC) progression via release of inflammatory ..
  55. Bernard Roizman; Fiscal Year: 2014
    ..Class C includes mRNAs that are not degraded. The products of these mRNAs include tristetraprolin, a stress inducible protein that binds to AU-rich elements and sequesters the mRNAs to exosomes for 3'to ..
  56. LISA HELENE BUTTERFIELD; Fiscal Year: 2014
    ..This broad, polyclonal, multi-antigen immunity will also activate NK cells and improve time to progression (TTP) and health-related quality of life (HRQL)...
  57. Baek Kim; Fiscal Year: 2016
    ..We further showed that the cellular dUTP/TTP ratio determines the frequency of HIV-1 RT-mediated dUTP incorporation (which can be mutagenic)...
  58. Negative Impact of RNA Destabilizer Tristetraprolin on Glioma Growth
    ESTHER AZUNGWE SUSWAM; Fiscal Year: 2012
    ..The RNA destabilizing factor, tristetraprolin (TTP), has recently been identified as a critical attenuator of growth factor signaling in normal states...
  59. Lindy A McClelland; Fiscal Year: 2015
    ..by applicant): The control of epithelial tissue various stressful conditions, to identify the mechanism of Tis11 function in ISCs, and to establish whether Tis11 activity in ISCs influences age-related changes in homeostasis of ..
  60. Diane J Catellier; Fiscal Year: 2016
    ..design, monitoring, and analysis, including trials in hematological diseases (sickle cell disease, hemophilia and TTP)...
  61. Francesca Massi; Fiscal Year: 2015
    ..of this proposal is to understand how an important class of proteins, the CCCH zinc finger proteins of the tristetraprolin (TTP) family, recognizes and binds to mRNA to promote its degradation...
  62. TMH Clinical Trials Network-Wisconsin Core Clinical Center
    JANICE G MC FARLAND; Fiscal Year: 2012
    ..g. "Pipeline" trials: "HIT Observational Thromboembolism Study" (HOT), "Study of TTP and Rituximab: A Randomized Clinical Trial" (STAR) and "High Dose Granulocyte Transfusions for the Treatment of ..
  63. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..zebrafish model is ideal for our studies because it, like humans, has a preference for - tocopherol, expresses the ttp gene and requires vitamin C, an important determinant in - tocopherol antioxidant function in humans...
  64. Oklahoma-UT Southwestern Hemostasis Consortium
    James N George; Fiscal Year: 2013
    ..clinical trial, PLADO. For TTP, Dr. George was the initial co-chair of this subcommittee and remains a leader in the development of the STAR trial...