TRIM22

Summary

Gene Symbol: TRIM22
Description: tripartite motif containing 22
Alias: GPSTAF50, RNF94, STAF50, E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, staf-50, stimulated trans-acting factor (50 kDa), tripartite binding motif 22, tripartite motif protein TRIM22, tripartite motif-containing protein 22
Species: human

Top Publications

  1. doi B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies
    Gayathri Sivaramakrishnan
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    FEBS Lett 583:2093-9. 2009
  2. ncbi Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages
    Abdellatif Bouazzaoui
    Georg Speyer Haus, Institute for Biomedical Research, 60596 Frankfurt M, Germany
    Virology 356:79-94. 2006
  3. pmc TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation
    Andrea Di Pietro
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Virol 87:4523-33. 2013
  4. doi Identification of TRIM22 as a RING finger E3 ubiquitin ligase
    Zhijian Duan
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    Biochem Biophys Res Commun 374:502-6. 2008
  5. pmc The interferon response inhibits HIV particle production by induction of TRIM22
    Stephen D Barr
    Department of Medical Microbiology and Immunology, University of Alberta, Alberta Institute for Viral Immunology, Edmonton, Alberta, Canada
    PLoS Pathog 4:e1000007. 2008
  6. ncbi Unique features of TRIM5alpha among closely related human TRIM family members
    Xing Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 360:419-33. 2007
  7. pmc Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection
    Ravesh Singh
    Doris Duke Medical Research Institute, University of KwaZulu Natal, Private Bag X7, Congella, Durban 4001, South Africa
    J Virol 85:208-16. 2011
  8. pmc The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production
    Seiga Ohmine
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e16121. 2011
  9. pmc TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements
    Anna Kajaste-Rudnitski
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    J Virol 85:5183-96. 2011
  10. ncbi Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression
    C Tissot
    Institut de Genetique Moleculaire de Montpellier UMR 9942, CNRS, France
    J Biol Chem 270:14891-8. 1995

Scientific Experts

  • Susanna Obad
  • Stephen D Barr
  • Lionel Berthoux
  • Serena Martire
  • Patrick Eldin
  • Anna Kajaste-Rudnitski
  • Xiao yang Mo
  • Anna Maria Herr
  • Jessica Petersson
  • Bo Gao
  • Inna G Ovsyannikova
  • Wei Xu
  • Sidong Xiong
  • Jenna N Kelly
  • Yaxin Wang
  • Jia Wu Zhu
  • Gayathri Sivaramakrishnan
  • Filippo Turrini
  • Hui Qiu
  • Zhijian Duan
  • Ravesh Singh
  • Gregory A Poland
  • Yang Sun
  • Silvia Ghezzi
  • Elisa Vicenzi
  • Megan M O'Byrne
  • Iana H Haralambieva
  • Valerie C L Lin
  • Chi Chen
  • Feng Liang Liu
  • Dan Mu
  • Yong Tang Zheng
  • De Yao Deng
  • Qi Li
  • J I Velez
  • Luz M Medrano
  • Ronald Moura Rodrigues
  • Greta Forlani
  • Natacha Merindol
  • Weihua Zhan
  • Mayuko Saito-Kanatani
  • Kiran D Mir
  • Xing Li
  • Zhihai Si
  • Guido Silvestri
  • Guido Poli
  • Han Xiao
  • Michael A Mandell
  • Sara Marelli
  • Fang Huang
  • William E Diehl
  • Bjørn A Nexø
  • Andrea Di Pietro
  • Linmao Zhong
  • Marianeve Carotenuto
  • Patrick Coit
  • Lise Werner
  • Thumbi Ndung'u
  • Salim S Abdool Karim
  • Jeremy Luban
  • Koleka Mlisana
  • V Shane Pankratz
  • Clayton J Hattlmann
  • Viviana Cobos Jiménez
  • Robert A Vierkant
  • Milan E Folkers
  • Seiga Ohmine
  • Shanshan Yu
  • Neelam Dhiman
  • Robert M Jacobson
  • Stuart Neil
  • Catherine Wölfel
  • Stefanie Wittmann
  • Sara L Sawyer
  • Byeongwoon Song
  • Michael Dean
  • Wen Yuan
  • Joseph Sodroski
  • Colm O'hUigin
  • Abdellatif Bouazzaoui
  • B Zirn
  • C Tissot
  • Y J Deng
  • Baoli Cheng
  • Shu Fang
  • Qixing Chen
  • Dongyan Zhao
  • Qiang Shu
  • Xiangming Fang
  • Y Cai

Detail Information

Publications71

  1. doi B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies
    Gayathri Sivaramakrishnan
    School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
    FEBS Lett 583:2093-9. 2009
    Tripartite motif-containing 22 (TRIM22) is an important antiviral protein that forms distinct nuclear bodies (NB) in many cell types...
  2. ncbi Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages
    Abdellatif Bouazzaoui
    Georg Speyer Haus, Institute for Biomedical Research, 60596 Frankfurt M, Germany
    Virology 356:79-94. 2006
    ..Using the microarray technology we identified a gene named Stimulated Trans-Acting Factor of 50 kDa (Staf50), which is known to repress the activity of the HIV-1 LTR...
  3. pmc TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation
    Andrea Di Pietro
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Virol 87:4523-33. 2013
    ..In particular, TRIM22 was reported to exert antiviral activity against RNA viruses, such as hepatitis B virus (HBV), ..
  4. doi Identification of TRIM22 as a RING finger E3 ubiquitin ligase
    Zhijian Duan
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    Biochem Biophys Res Commun 374:502-6. 2008
    b>TRIM22, a member of the TRIM family proteins which contain RING finger, B-box, and coiled-coil domains, has been reported as a transcriptional regulator and involved in various cellular processes...
  5. pmc The interferon response inhibits HIV particle production by induction of TRIM22
    Stephen D Barr
    Department of Medical Microbiology and Immunology, University of Alberta, Alberta Institute for Viral Immunology, Edmonton, Alberta, Canada
    PLoS Pathog 4:e1000007. 2008
    Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator...
  6. ncbi Unique features of TRIM5alpha among closely related human TRIM family members
    Xing Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 360:419-33. 2007
    ..In contrast to the other TRIM genes examined, TRIM5 exhibited evidence of positive selection. The unique features of TRIM5alpha among its TRIM relatives underscore its special status as an antiviral factor...
  7. pmc Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection
    Ravesh Singh
    Doris Duke Medical Research Institute, University of KwaZulu Natal, Private Bag X7, Congella, Durban 4001, South Africa
    J Virol 85:208-16. 2011
    ..We measured IFN-α, IFN-β, myxovirus resistance protein A (MxA), human TRIM5α (huTRIM5α), and TRIM22 mRNA levels in peripheral blood mononuclear cells (PBMCs) of high-risk, HIV-1-uninfected participants and HIV-1-..
  8. pmc The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production
    Seiga Ohmine
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e16121. 2011
    ..Although all TRIM family proteins have RBCC domains, it remains elusive whether they possess similar late-restriction activities...
  9. pmc TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements
    Anna Kajaste-Rudnitski
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    J Virol 85:5183-96. 2011
    ..Among known HIV-1 restriction factors screened, tripartite motif-containing protein 22 (TRIM22) was the only factor constitutively expressed in nonpermissive and absent in permissive U937 cells...
  10. ncbi Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression
    C Tissot
    Institut de Genetique Moleculaire de Montpellier UMR 9942, CNRS, France
    J Biol Chem 270:14891-8. 1995
    ..These data are consistent with a role of Staf-50 in the mechanism of transduction of the IFN antiviral action...
  11. ncbi The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28
    C Gongora
    INSERM Unité U475, 34197 Montpellier Cedex 5, France
    J Interferon Cytokine Res 20:955-61. 2000
    ..2 subfamily that localizes to the chromosome band 11p15. We have named it Staf50. We show in this report that Staf50 is expressed in resting T cells in the absence of exogenous IFN treatment and ..
  12. pmc TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment
    Ravesh Singh
    KwaZulu Natal Research Institute for Tuberculosis and HIV K RITH, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    J Virol 88:4291-303. 2014
    The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, ..
  13. doi Ancient and recent adaptive evolution in the antiviral TRIM22 gene: identification of a single-nucleotide polymorphism that impacts TRIM22 function
    Jenna N Kelly
    Department of Microbiology and Immunology, Center for Human Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    Hum Mutat 35:1072-81. 2014
    Tripartite motif protein 22 (TRIM22) is a novel interferon-induced protein that potently inhibits the replication of evolutionarily diverse viruses, including HIV-1...
  14. pmc In silico analysis of functional single nucleotide polymorphisms in the human TRIM22 gene
    Jenna N Kelly
    Western University, Schulich School of Medicine and Dentistry, Center for Human Immunology, Department of Microbiology and Immunology, Dental Sciences Building, London, Ontario, Canada
    PLoS ONE 9:e101436. 2014
    Tripartite motif protein 22 (TRIM22) is an evolutionarily ancient protein that plays an integral role in the host innate immune response to viruses...
  15. pmc TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition
    Michael A Mandell
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Dev Cell 30:394-409. 2014
    ..Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells...
  16. doi TRIM22 can activate the noncanonical NF-κB pathway by affecting IKKα
    Hui Qiu
    a Research Group of HIV Molecular Epidemiology and Virology, Center for Emerging Infectious Diseases, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, PR China
    J Recept Signal Transduct Res 35:289-94. 2015
    Tripartite motif 22 (TRIM22) is involved in various cellular processes. It has been reported that TRIM22 can activate nuclear factor-κB (NF-κB) pathway, but the precise mechanism remains unclear...
  17. ncbi Restriction Factors in HIV-1 Disease Progression
    Natacha Merindol
    Department of Medical Biology, Universite du Quebec a Trois Rivieres, 3351 Boulevard des Forges, Trois Rivieres, QC, G9A 5H7 Canada
    Curr HIV Res 13:448-61. 2015
    ..TRIM5α, Mx2/MxB, TRIM22/Staf50, SAMHD1, p21/CDKN1, tetherin/BST2/CD137, APOBEC3G and APOBEC3F have all been proposed to inhibit HIV-1, ..
  18. pmc Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors
    Kiran D Mir
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Virol 89:10136-44. 2015
    ..003) and TRIM22 (P = 0...
  19. doi Identification of TRIM22 as a progesterone-responsive gene in Ishikawa endometrial cancer cells
    Mayuko Saito-Kanatani
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Department of Obstetrics and Gynaecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Steroid Biochem Mol Biol 154:217-25. 2015
    ..Out of these 15 genes, we focused on TRIM22. A database search revealed a progesterone response element (PRE) located from the -25 to -11 bp region upstream ..
  20. doi Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication
    Jia Wu Zhu
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
    Microbes Infect . 2017
    ..those IDUs and non-IDUs without HIV-1 infection, and found IDUs had significantly lower levels of TRIM5α, TRIM22, APOBEC3G, and IFN-α, -β expression than did non-IDUs...
  21. pmc Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 1st Street S W, Rochester, Minnesota, 55905, USA
    Immunogenetics 67:547-61. 2015
    ..Of these SNPs, we detected eight in the PVRL3 gene, five in the PVRL1 gene, one in the TRIM22 gene, two in the IL10RB gene, two in the TLR4 gene, and five in other genes (PVR, ADAR, ZFP57, MX1, and BTN2A1/..
  22. pmc TRIM22-Mediated Apoptosis is Associated with Bak Oligomerization in Monocytes
    Chi Chen
    Department of Thoracic and Cardiovascular Surgery, Children s Hospital, School of Medicine, Zhejiang University, and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Hangzhou 310052, China
    Sci Rep 7:39961. 2017
    Monocyte apoptosis is a key mechanism that orchestrates host immune responses during sepsis. TRIM22 is constitutively expressed at high levels in monocytes and plays important roles in the antiviral response and inflammation...
  23. ncbi Genome-wide scan in two groups of HIV-infected patients treated with dendritic cell-based immunotherapy
    Ronald Moura Rodrigues
    Department of Genetics, Federal University of Pernambuco, Recife, Brazil
    Immunol Res 64:1207-1215. 2016
    ..We identified a genetic variation (rs7935564 G allele) in TRIM22 gene, which encodes TRIM22 protein acting like a HIV restriction factor, as being associated with good response to ..
  24. pmc Relationship of TRIM5 and TRIM22 polymorphisms with liver disease and HCV clearance after antiviral therapy in HIV/HCV coinfected patients
    Luz M Medrano
    Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III Campus Majadahonda, Carretera Majadahonda Pozuelo, Km 2 2, 28220, Majadahonda, Madrid, Spain
    J Transl Med 14:257. 2016
    TRIM5 and TRIM22 are restriction factors involved in innate immune response and exhibit anti-viral activity...
  25. pmc The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells
    Greta Forlani
    Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy
    J Transl Med 14:94. 2016
    ..This different phenotype has been associated with the expression of TRIM22 in U937 Minus but not in Plus cells.
  26. doi A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients
    Serena Martire
    AOU San Luigi Gonzaga, Neurologia 2 CRESM Regional Referring Center of Multiple Sclerosis, Neurobiology Unit, Orbassano, TO, Italy Neuroscience Institute Cavalieri Ottolenghi NICO, Orbassano, TO, Italy Electronic address
    J Neuroimmunol 292:34-9. 2016
    ..level of 25 interferon-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L, TRIM22, IL10, CXCL10, STAT1, OAS1, OAS2, IFNAR1, IFNAR2, IFNβ, ISG20, IFI6, PKR, IRF7, USP18), recurrently proposed in ..
  27. pmc Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease
    Qi Li
    SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Gastroenterology 150:1196-207. 2016
    ..We performed whole-exome sequence (WES) analysis to identify genetic factors that might cause granulomatous colitis and severe perianal disease, with recurrent bacterial and viral infections, in an infant of consanguineous parents...
  28. pmc HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter
    Filippo Turrini
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, P2 P3 Laboratories, DIBIT, Via Olgettina n 58, 20132, Milan, Italy
    Retrovirology 12:104. 2015
    ..Among these, we have shown that Tripartite motif 22 (TRIM22) suppresses basal as well as phorbol ester-induced HIV-1 long terminal repeat (LTR)-mediated transcription, ..
  29. doi APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease
    J I Velez
    Genomics and Predictive Medicine Group, Department of Genome Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
    Mol Psychiatry 21:916-24. 2016
    ..e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele...
  30. pmc TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins
    Weihua Zhan
    Institute of Translation Medicine, Nanchang University, Nanchang City, Jiangxi, 330031, China
    PLoS ONE 10:e0142596. 2015
    ..NSCLC) cell lines, we found that the expression of 10 TRIM genes including TRIM3, TRIM7, TRIM14, TRIM16, TRIM21, TRIM22, TRIM29, TRIM59, TRIM66 and TRIM70 was significantly upregulated in NSCLC cell lines compared with the normal ..
  31. doi Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients
    Jia Wu Zhu
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    J Med Virol 88:987-95. 2016
    ..In this study, we measured the levels of TRIM5α, TRIM22, APOBEC3G, and IFN-α, -β mRNA expression in peripheral blood mononuclear cells of 43 HIV mono-infected, 70 HCV ..
  32. ncbi Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters
    B Zirn
    Physiological Chemistry I, Biozentrum, University of Wuerzburg, Germany
    Int J Cancer 118:1954-62. 2006
    ..Several differentially expressed genes, e.g.TRIM22, CENPF, MYCN, CTGF, RARRES3 and EZH2, were associated with Wilms tumor progression...
  33. doi BRG1 is indispensable for IFN-γ-induced TRIM22 expression, which is dependent on the recruitment of IRF-1
    Yaxin Wang
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 410:549-54. 2011
    ..we report that Brahma-related gene 1 (BRG1), a chromatin remodeling enzyme, plays a crucial role in IFN-γ-induced TRIM22 expression...
  34. pmc Restriction genes for retroviruses influence the risk of multiple sclerosis
    Bjørn A Nexø
    Department of Biomedicine, Aarhus University, Aarhus C, Denmark
    PLoS ONE 8:e74063. 2013
    ..We here report that markers in two TRIMs, TRIM5 and TRIM22 and a marker in BST2, associated statistically with the risk of getting MS, while markers in or near APOBEC3s and ..
  35. doi Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease
    Silvia Ghezzi
    aViral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases bDepartment of Infectious Diseases cDivision of Genetics and Cell Biology, San Raffaele Scientific Institute dUniversity of Milan eGEMIB srl, Parma fAIDS Immunopathogenesis Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute gUniversità Vita Salute San Raffaele, School of Medicine, Milan, Italy
    AIDS 27:2335-44. 2013
    Tripartite motif-containing 22 (TRIM22) is an interferon-induced protein that inhibits HIV-1 transcription and replication in vitro...
  36. doi Down-regulation of tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction
    Yang Sun
    School of Biological Sciences, Nanyang Technological University, Singapore
    Biochem Biophys Res Commun 441:600-6. 2013
    Tripartite-motif containing 22 (TRIM22) is a direct p53 target gene and inhibits the clonogenic growth of leukemic cells. Its expression in Wilms tumors is negatively associated with disease relapse...
  37. pmc Induction of TRIM22 by IFN-γ Involves JAK and PC-PLC/PKC, but Not MAPKs and pI3K/Akt/mTOR Pathways
    Bo Gao
    1 Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, P R China
    J Interferon Cytokine Res 33:578-87. 2013
    ..We previously demonstrated that interferon regulatory factor-1 (IRF-1) played a central role in IFN-γ-induced TRIM22 expression via binding to a special cis-element named 5' extended IFN-stimulating response element (5'eISRE)...
  38. ncbi Complexity of inflammatory responses in endothelial cells and vascular smooth muscle cells determined by microarray analysis
    Olga Bandman
    Incyte Genomics, Palo Alto, California 94304, USA
    Ann N Y Acad Sci 975:77-90. 2002
    ..In addition, 43 genes likely to participate in signal transduction (eg. IL-18 receptor, STK2 kinase, STAF50, ANP receptor, VIP receptor, RAC3, IFP35) were regulated providing evidence that a major effect of TNFalpha and IL-..
  39. pmc Associations between polymorphisms in the antiviral TRIM genes and measles vaccine immunity
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, United States
    Hum Immunol 74:768-74. 2013
    ..b>TRIM22 rs2291841 was significantly associated with an increased IFN-γ Elispot response (35 vs...
  40. doi TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation
    Hui Qiu
    Research Group of HIV Molecular Epidemiology and Virology, Center for Emerging Infectious Diseases, The State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Virol Sin 28:209-15. 2013
    Tripartite motif containing 22 (TRIM22), a member of the TRIM/RBCC family, has been reported to activate the nuclear factor-kappa B (NF-κB) pathway in unstimulated macrophage cell lines, but the detailed mechanisms governing this ..
  41. pmc Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation
    William E Diehl
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e58532. 2013
    All genes in the TRIM6/TRIM34/TRIM5/TRIM22 locus are type I interferon inducible, with TRIM5 and TRIM22 possessing antiviral properties...
  42. pmc Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients
    Patrick Coit
    Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    J Autoimmun 43:78-84. 2013
    ..genes in naïve CD4+ T cells from lupus patients, including IFIT1, IFIT3, MX1, STAT1, IFI44L, USP18, TRIM22 and BST2, suggesting epigenetic transcriptional accessibility in these genetic loci...
  43. doi p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity
    Bo Gao
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Eur J Immunol 43:2174-84. 2013
    ..We previously demonstrated that IFN regulatory factor-1 (IRF-1) was crucial for constitutive and IFN-induced TRIM22 expression via binding to a special cis-element named 5' extended IFN-stimulating response element...
  44. doi Inhibition of histone deacetylase activity suppresses IFN-γ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1
    Bo Gao
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    J Immunol 191:464-71. 2013
    ..We previously demonstrated that IFN regulatory factor (IRF)-1 was crucial for basal and IFN-induced TRIM22 transcription via binding to a novel cis-element named 5' extended IFN-stimulating response element...
  45. doi The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G
    Jessica Petersson
    Department of Haematology and Transfusion Medicine, Biomedical Centre, Lund University, 221 84 Lund, Sweden
    Biol Cell 104:462-75. 2012
    The interferon (IFN)-inducible protein TRIM22 (Staf50) is a member of the tripartite motif protein family and has been suggested a role in the regulation of viral replication as well as of protein ubiquitylation...
  46. pmc Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons
    Viviana Cobos Jiménez
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam CINIMA at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Sci Rep 2:763. 2012
    ..Here, we observed that the expression levels of the cellular factors Trim5α, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-α and ..
  47. pmc TRIM22: A Diverse and Dynamic Antiviral Protein
    Clayton J Hattlmann
    Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON, Canada N6A 5C1
    Mol Biol Int 2012:153415. 2012
    ..Human TRIM22 is one such protein that has a dynamic evolutionary history that includes gene expansion, gene loss, and strong ..
  48. pmc Human immunodeficiency virus, restriction factors, and interferon
    Stuart Neil
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    J Interferon Cytokine Res 29:569-80. 2009
    ..Such knowledge could allow for novel forms of therapeutic intervention in pathogenic retroviral infections, as well as the development of animal models of human disease...
  49. pmc Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction
    Marianeve Carotenuto
    Centro di Ingegneria Genetica e Biotecnologie Avanzate CEINGE, Naples, Italy
    Sci Rep 3:1351. 2013
    ..We also identified two other proteins (PTPRA and TRIM22) with expression levels significantly affected by CPP...
  50. ncbi Localization of Staf50, a member of the Ring finger family, to 11p15 by fluorescence in situ hybridization
    C Tissot
    Institut de Genetique Moleculaire de Montpellier, UMR 5535
    Genomics 34:151-3. 1996
  51. ncbi Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells
    Susanna Obad
    Department of Hematology, Lund University, BMC C14, Lund S 221 84, Sweden
    Oncogene 23:4050-9. 2004
    ..We report that transcription of the Staf50 (stimulated transacting factor of 50 kDa) gene is upregulated in response to wild-type p53 in U-937-4, K562 and ..
  52. ncbi Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus
    Y J Deng
    Department of Dermatology, Southwest Hospital, The Third Military Medical University, Chongqing 400038, PR China
    Mol Immunol 43:1497-507. 2006
    ..viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes ..
  53. pmc Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection
    Zhihai Si
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7454-9. 2006
    ..In humans, TRIM5 is located in a paralogous cluster that includes TRIM6, TRIM34, and TRIM22. Although TRIM6 and TRIM34 orthologs are found in other mammals, TRIM5 has to date been identified only in ..
  54. ncbi Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow
    Susanna Obad
    Department of Haematology and Transfusion Medicine, Biomedical Centre, Lund University, Lund, Sweden
    Leuk Res 31:995-1001. 2007
    The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells...
  55. ncbi Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus
    Xiao yang Mo
    Center for Heart Development, Key Lab of National Education Ministry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Med Virol 79:1783-91. 2007
    ..stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif-containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]...
  56. ncbi Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation
    Susanna Obad
    Department of Haematology and Transfusion Medicine, Lund University, S 221 84 Lund, Sweden
    J Interferon Cytokine Res 27:857-64. 2007
    TRIM22 (Staf50) is an interferon (IFN)-inducible protein with unknown function. Recently, we identified TRIM22 as a novel p53 target gene and showed that overexpression of TRIM22 inhibits the clonogenic growth of monoblastic U937 cells...
  57. ncbi Dissection and molecular analysis of alloreactive CD8+ T cell responses in allogeneic haematopoietic stem cell transplantation
    Catherine Wölfel
    III Department of Internal Medicine, Haematology Oncology, Johannes Gutenberg University, 55101 Mainz, Germany
    Cancer Immunol Immunother 57:849-57. 2008
    ..by TRIM22-442 C, a newly detected polymorphic allele of the tripartite motif family member TRIM22 (synonym: STAF50), preferentially expressed in cells of the haematopoietic system...
  58. pmc Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 3:e197. 2007
    ..Here, we present an evolutionary comparison of the TRIM5 gene to its closest human paralogs: TRIM22, TRIM34, and TRIM6...
  59. doi New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors
    Stefanie Wittmann
    Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, Wuerzburg, Germany
    Genes Chromosomes Cancer 47:386-95. 2008
    ..multivariate analysis revealed potentially relevant alteration of CA9, DKK1, EGR1, HEY2, MYC, MYCN, TERT, TOP2A, TRIM22, and VEGF expression in association with CTNNB1 mutation status, histological risk, response to chemotherapy, ..
  60. pmc Different subcellular localisations of TRIM22 suggest species-specific function
    Anna Maria Herr
    Department of Primate Genetics, German Primate Center, Gottingen, Germany
    Immunogenetics 61:271-80. 2009
    ..2 domain that evolves rapidly in primates and exhibits species-specific anti-viral activity. TRIM22 is another positively selected TRIM gene. Particularly, the B30...
  61. doi TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus
    Patrick Eldin
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    J Gen Virol 90:536-45. 2009
    ..In this report, we provide evidence that TRIM22 is a functional E3 ubiquitin ligase that is also ubiquitinated itself...
  62. doi Dynamic localization of tripartite motif-containing 22 in nuclear and nucleolar bodies
    Gayathri Sivaramakrishnan
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    Exp Cell Res 315:1521-32. 2009
    Tripartite motif-containing 22 (TRIM22) exhibits antiviral and growth inhibitory properties, but there has been no study on the localization and dynamics of the endogenous TRIM22 protein...
  63. doi Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain
    Bo Gao
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, People s Republic of China
    Hepatology 50:424-33. 2009
    ..b>TRIM22 has been reported to possess antiretroviral activity...
  64. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination...
  65. doi Restriction factors of retroviral replication: the example of Tripartite Motif (TRIM) protein 5 alpha and 22
    Anna Kajaste-Rudnitski
    Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Amino Acids 39:1-9. 2010
    ..This article reviews, in particular, the current knowledge on the anti-retroviral effects of TRIM5 alpha and TRIM22.
  66. pmc Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 201:207-13. 2010
    ..Genetic polymorphisms play an important role in rubella vaccine-induced immunity...
  67. doi The human IFN-inducible p53 target gene TRIM22 colocalizes with the centrosome independently of cell cycle phase
    Jessica Petersson
    Department of Hematology and Transfusion Medicine, Biomedical Center, Lund University, 221 84 Lund, Sweden
    Exp Cell Res 316:568-79. 2010
    TRIM22 (Staf50), a member of the TRIM protein family, is an interferon (IFN)-inducible protein as well as a p53 target gene...
  68. doi A 5' extended IFN-stimulating response element is crucial for IFN-gamma-induced tripartite motif 22 expression via interaction with IFN regulatory factor-1
    Bo Gao
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    J Immunol 185:2314-23. 2010
    ..However, the molecular mechanism of TRIM22 induction by IFN-gamma is still unclear...
  69. pmc ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver
    Milan E Folkers
    Department of Medicine, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 6:e14697. 2011
    ..qPCR analysis of liver biopsy specimens demonstrated that these unannotated transcripts, as well as IRF1, TRIM22 and MET, were also upregulated in hepatitis C with mild inflammation and no fibrosis...
  70. doi Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator
    Shanshan Yu
    Institute for Immunobiology, Department of Immunology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 410:247-51. 2011
    ..Here we report TRIM22 is involved in the activation of NF-κB...