TRIM21

Summary

Gene Symbol: TRIM21
Description: tripartite motif containing 21
Alias: RNF81, RO52, Ro/SSA, SSA, SSA1, E3 ubiquitin-protein ligase TRIM21, 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RING finger protein 81, RING-type E3 ubiquitin transferase TRIM21, SS-A, Sicca syndrome antigen A, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro), ro(SS-A), sjoegren syndrome type A antigen, tripartite motif-containing protein 21
Species: human

Top Publications

  1. ncbi Regulation of mRNA export in response to stress in Saccharomyces cerevisiae
    C Saavedra
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 10:1608-20. 1996
  2. ncbi Acclimation of shoot and needle morphology and photosynthesis of two Picea species to differences in soil nutrient availability
    Hiroaki Ishii
    Biosphere Dynamics Research Group, Institute of Low Temperature Science, Hokkaido University, Sapporo 060 0819, Japan
    Tree Physiol 23:453-61. 2003
  3. doi Outcome and growth of infants fetally exposed to heart block-associated maternal anti-Ro52/SSA autoantibodies
    Amanda Skog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Pediatrics 121:e803-9. 2008
  4. doi The experiences of pregnancy in women with SSA/Ro52 autoantibodies
    Joanna Tingström
    Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    Musculoskeletal Care 8:215-23. 2010
  5. pmc Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia
    Vincent T Bicocca
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Cell 22:656-67. 2012
  6. pmc Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen
    E K Chan
    Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, California 92037
    J Clin Invest 87:68-76. 1991
  7. ncbi SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production
    Tomonori Ishii
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:3653-61. 2003
  8. ncbi Antiretroviral potential of human tripartite motif-5 and related proteins
    Fengwen Zhang
    Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 353:396-409. 2006
  9. ncbi TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Mol Immunol 44:2406-14. 2007
  10. ncbi Unique features of TRIM5alpha among closely related human TRIM family members
    Xing Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 360:419-33. 2007

Research Grants

  1. DEATH RATES AND DEATH DATA FOR ASIAN AMERICAN ELDERLY
    Diane Lauderdale; Fiscal Year: 2003
  2. JILL PAMELA BUYON; Fiscal Year: 2015
  3. CELLULAR MECHANISMS OF AUTOIMMUNE ASSOCIATED CONGENITAL
    Mohamed Boutjdir; Fiscal Year: 1999
  4. RESEARCH REGISTRY FOR NEONATAL LUPUS
    JILL PAMELA BUYON; Fiscal Year: 2010
  5. RESEARCH REGISTRY FOR NEONATAL LUPUS
    JILL PAMELA BUYON; Fiscal Year: 2009
  6. A MODEL OF SJOGREN'S SYNDROME WITH ANTI-RO/LA ANTIBODIES
    R Scofield; Fiscal Year: 2001
  7. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
  8. GLENN JOHN WAGNER; Fiscal Year: 2015
  9. Role of Ca channels in congenital heart block
    Mohamed Boutjdir; Fiscal Year: 2007
  10. Georgette D Kanmogne; Fiscal Year: 2016

Detail Information

Publications268 found, 100 shown here

  1. ncbi Regulation of mRNA export in response to stress in Saccharomyces cerevisiae
    C Saavedra
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 10:1608-20. 1996
    ..In situ hybridization indicated that heat-inducible SSA4 and SSA1 mRNAs were exported from nuclei under these same conditions...
  2. ncbi Acclimation of shoot and needle morphology and photosynthesis of two Picea species to differences in soil nutrient availability
    Hiroaki Ishii
    Biosphere Dynamics Research Group, Institute of Low Temperature Science, Hokkaido University, Sapporo 060 0819, Japan
    Tree Physiol 23:453-61. 2003
    ..increments in the previous year and more needles per shoot length and, hence, a smaller shoot silhouette area (SSA) relative to needle dry mass (NDM) than trees growing on brown forest soil...
  3. doi Outcome and growth of infants fetally exposed to heart block-associated maternal anti-Ro52/SSA autoantibodies
    Amanda Skog
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Pediatrics 121:e803-9. 2008
    ..work was to analyze outcome with focus on growth in infants fetally exposed to heart block-associated maternal anti-Ro52/SSA autoantibodies and identify maternal factors other than the autoantibodies increasing the risk of fetal heart ..
  4. doi The experiences of pregnancy in women with SSA/Ro52 autoantibodies
    Joanna Tingström
    Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
    Musculoskeletal Care 8:215-23. 2010
    Congenital heart block may develop in the foetus during pregnancy in SSA/Ro52 autoantibody-positive women...
  5. pmc Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia
    Vincent T Bicocca
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Cell 22:656-67. 2012
    ..Consequently, ROR1 silencing accentuates dasatinib killing of t(1;19) ALL cells...
  6. pmc Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen
    E K Chan
    Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, California 92037
    J Clin Invest 87:68-76. 1991
    ....
  7. ncbi SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production
    Tomonori Ishii
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:3653-61. 2003
    An autoantibody against SS-A/Ro52 (Ro52) is most frequently found in the sera of patients with Sjögren's syndrome, systemic lupus erythematosus, and congenital heart block from anti-Ro52 Ab-positive mother...
  8. ncbi Antiretroviral potential of human tripartite motif-5 and related proteins
    Fengwen Zhang
    Aaron Diamond AIDS Research Center and the Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Virology 353:396-409. 2006
    ..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins...
  9. ncbi TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain
    David A Rhodes
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Mol Immunol 44:2406-14. 2007
    ..Auto-antibodies to TRIM21 (Ro52) are a common serological feature of patients with Sjogren's syndrome and systemic lupus erythematosus (SLE)...
  10. ncbi Unique features of TRIM5alpha among closely related human TRIM family members
    Xing Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 360:419-33. 2007
    ..In contrast to the other TRIM genes examined, TRIM5 exhibited evidence of positive selection. The unique features of TRIM5alpha among its TRIM relatives underscore its special status as an antiviral factor...
  11. doi Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role
    Keiko Yamauchi
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    FEBS J 275:1540-55. 2008
    ..In addition to the self-ubiquitination, we show that TRIM5alpha is ubiquitinated by another E3 ubiquitin ligase, Ro52, and deubiquitinated by YopJ, one of the pathogenic proteins derived from Yersinia species...
  12. pmc TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved
    Anthony H Keeble
    Division of Protein and Nucleic Acid Chemistry, Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 105:6045-50. 2008
    ..Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjögren's ..
  13. pmc The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
    Rowan Higgs
    Molecular and Cellular Therapeutics, Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Immunol 181:1780-6. 2008
    ..In this study, we provide evidence that the E3 ligase Ro52 (TRIM21) targets IRF3 for degradation post-pathogen recognition receptor activation...
  14. doi The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide
    Alexander Espinosa
    Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Exp Cell Res 314:3605-13. 2008
    ..Sjögrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1...
  15. pmc The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity
    Ji Young Kim
    Laboratory of Molecular Growth Regulation, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2131-40. 2009
    ..We show that p62 interacts with IFN regulatory factor 8 and Ro52, the transcription factor and ubiquitin E3 ligase that are important for IL-12p40 expression...
  16. doi TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response
    Kai Yang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Immunol 182:3782-92. 2009
    ..Herein we report that TRIM21 (tripartite motif-containing 21) is significantly induced and interacts with IRF3 upon RNA virus infection...
  17. pmc Downregulation of active IKK beta by Ro52-mediated autophagy
    Motoko Niida
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Immunol 47:2378-87. 2010
    ..But the active IKK beta is conjugated with a monoubiquitin by the E3 ubiquitin ligase Ro52, and the IKK beta-induced NF-kappaB signaling is downregulated...
  18. pmc Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors
    Rowan Higgs
    Molecular and Cellular Therapeutics and RSCI Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 5:e11776. 2010
    b>Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren's syndrome...
  19. pmc Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
    Donna L Mallery
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 107:19985-90. 2010
    ..We have discovered that cells possess a cytosolic IgG receptor, tripartite motif-containing 21 (TRIM21), which binds to antibodies with a higher affinity than any other IgG receptor in the human body...
  20. pmc Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production
    Jennifer A Young
    Cancer Research Laboratory and Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720, USA
    J Biol Chem 286:6521-31. 2011
    ..described as an apoptotic protein, is involved in regulating IFN-α production through a novel interaction with TRIM21. TRIM21 is a member of a large family of proteins that can impart ubiquitin modification onto its cellular targets...
  21. pmc Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity
    Kevin B Stacey
    Department Molecular and Cellular Therapeutics, Royal College Surgeons in Ireland Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e34041. 2012
    ..b>TRIM21, an autoantigen associated with SLE, has been identified as an ubiquitin E3 ligase that targets the transcription ..
  22. pmc Regulation of virus neutralization and the persistent fraction by TRIM21
    W A McEwan
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Virol 86:8482-91. 2012
    ..of adenovirus type 5, a prevalent nonenveloped human virus, are dependent upon the intracellular antibody receptor TRIM21. Cells with insufficient amounts of TRIM21 are readily infected, even at saturating concentrations of neutralizing ..
  23. ncbi A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region
    G Bepler
    Thoracic Oncology Program, Department of Medicine and Department of Radiology, Durham, North Carolina, 27710, USA
    Genomics 55:164-75. 1999
    ..The malignant phenotype, in this case, results from a relative loss of function rather than a complete loss...
  24. pmc Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways...
  25. pmc Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
    Leo C James
    Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Proc Natl Acad Sci U S A 104:6200-5. 2007
    ..70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles...
  26. ncbi Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages
    Hee Jeong Kong
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Drive, Bethesda, MD 20892, USA
    J Immunol 179:26-30. 2007
    ..Immunopurification and mass spectrometry analysis found that IRF-8 interacted with Ro52 in murine macrophages upon IFN-gamma and TLR stimulation...
  27. pmc The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production
    Seiga Ohmine
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e16121. 2011
    ..Although all TRIM family proteins have RBCC domains, it remains elusive whether they possess similar late-restriction activities...
  28. ncbi The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
    Alexander Espinosa
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Danderyd Hospital, Karolinska Institutet, S 17176 Stockholm, Sweden
    J Immunol 176:6277-85. 2006
    ..Sjögren's syndrome and systemic lupus erythematosus (SLE) carry autoantibodies to an intracellular protein denoted Ro52. Although the serologic presence of Ro52 autoantibodies is used clinically for diagnostic purposes, the function of ..
  29. pmc Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
    T O'CONNOR
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U K
    Biochem J 343:487-504. 1999
    ..was found to exhibit a narrow substrate specificity, with activity being restricted to succinic semialdehyde (SSA), 2-nitrobenzaldehyde, pyridine-2-aldehyde, isatin, 1,2-naphthoquinone (1,2-NQ) and 9,10-phenanthrenequinone...
  30. ncbi Neonatal lupus erythematosus related to maternal leukocytoclastic vasculitis
    L Borrego
    Department of Dermatology, Hospital Insular, Las Palmas de Gran Canaria, Canary Islands, Spain
    Pediatr Dermatol 14:221-5. 1997
    ..Affected infants have maternal, transplacentally acquired, autoantibodies to Ro/SSA, La/SSB, or U1-RNP antigens. Anti-Ro/SSA is the predominant autoantibody, present in about 95% of cases...
  31. ncbi Expression of acid phosphatase-beta-galactosidase hybrid proteins prevents translocation by depleting a soluble factor
    M R Young
    Department of Biological Chemistry, University of Maryland, Baltimore 21201
    J Biol Chem 265:19824-32. 1990
    ..This deficiency is complemented by addition of cytosol prepared from wild type cells. Finally, the hybrid protein phenotype is shown to be independent of the requirement for SSA gene products.
  32. ncbi Neonatal lupus erythematosus in an infant with Turner syndrome
    E Ruas
    Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal
    Pediatr Dermatol 13:298-302. 1996
    ..Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies...
  33. pmc A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress
    G Jung
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 156:559-70. 2000
    ..We isolated a dominant allele, SSA1-21, of a gene encoding an Hsp70 chaperone that impairs [PSI(+)] mitotic stability and weakens allosuppression ..
  34. ncbi Neonatal lupus erythematosus and maternal lupus erythematosus mimicking HELLP syndrome
    S Paton
    Dermatology Program, Children's Hospital, Boston, Massachusetts
    Pediatr Dermatol 10:177-81. 1993
    ..The patient had elevated Ro(SSA) and La(SSB) antibody titers, and studies performed on maternal blood disclosed positive antinuclear antibodies and ..
  35. ncbi [Differential diagnosis of necrotizing sarcoid angiitis: necrotizing sarcoid angiitis and collagen disease--a case report]
    C Armbruster
    II. Interne Lungenabteilung des Pulmologischen Zentrums der Stadt Wien
    Pneumologie 45:63-6. 1991
    ..Antinuclear antibodies and antibodies against SSA-RO and Scleroderma 70 were identified...
  36. doi Frequency of neuro-psychiatric dysfunction in anti-SSA/SSB exposed children with and without neonatal lupus
    A D Askanase
    Department of Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York, NY 10016, USA
    Lupus 19:300-6. 2010
    Neonatal lupus is a model of passively acquired autoimmunity whereby anti-SSA/Ro-SSB/La antibodies target the fetal heart and neonatal skin in a minority of cases...
  37. ncbi Prenatal diagnosis of persistent fetal bradycardia: report of four cases
    H W Huang
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung
    Chang Gung Med J 24:57-61. 2001
    ..and third cases of sustained fetal bradycardia had congenital complete heart block with positive titers for anti-Ro/SSA antibodies in both mothers and fetuses...
  38. ncbi Effects of estradiol and exogenous insulin-like growth factor I (IGF-I) on the IGF-I axis during growth hormone inhibition and antagonism
    M E Wilson
    Yerkes Primate Research Center, Emory University, Lawrenceville, Georgia 30043, USA
    J Clin Endocrinol Metab 83:4013-21. 1998
    ..c. infusion of a somatostatin analogue (octreotide, Sandoz; SSa; 6 microg/kg x day) with a 14-day washout period separating the two conditions...
  39. pmc Role of reciprocal exchange, one-ended invasion crossover and single-strand annealing on inverted and direct repeat recombination in yeast: different requirements for the RAD1, RAD10, and RAD52 genes
    F Prado
    , , Universidad de Sevilla, Spain
    Genetics 139:109-23. 1995
    ..reciprocal exchange and the nonconservative events, one-ended invasion crossover, and single-strand annealing (SSA). We suggest that one-ended invasion is RAD52 dependent, whereas SSA is RAD52 independent...
  40. pmc Clinical, immunological, and immunogenetic aspects of autoantibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren's syndrome (pSS): a European multicentre study
    A G Tzioufas
    Department of Pathophysiology, School of Medicine, University of Athens, Greece
    Ann Rheum Dis 61:398-404. 2002
    To investigate the clinical and immunogenetic aspects of antibody formation against Ro/SSA and La/SSB as well as their linear B cell epitopes in patients with primary Sjögren's syndrome (pSS) from different European countries.
  41. ncbi Analysis of spontaneous and double-strand break-induced recombination in rad mutants of S. pombe
    E A Fortunato
    Department of Biology, University of California San Diego, La Jolla 92093 0322, USA
    Mutat Res 364:14-60. 1996
    ..substrates yield Ade+ Ura+ convertants or Ade+ Ura- deletions, by the DSB/gap repair and single-strand annealing (SSA) pathways of recombination, respectively. In S...
  42. ncbi Evidence that microdeletions in the alpha globin gene protect against the development of sickle cell glomerulopathy in humans
    A Guasch
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 10:1014-9. 1999
    There is a large variability in the severity of the clinical manifestations of sickle cell anemia (SSA), including renal involvement...
  43. ncbi Natural antibodies in Microtus fortis react with antigens derived from four stages in the life-cycle of Schistosoma japonicum
    Y K He
    Hunan Institute of Parasitic Diseases, Yueyang, Hunan, China
    Ann Trop Med Parasitol 93:83-7. 1999
    The levels of antibodies which react with the cercarial antigens (CA), schistosomulum stage antigens (SSA), adult-worm antigens (AWA) and soluble egg antigens (SEA) of Schistosoma japonicum were investigated in Microtus fortis and albino ..
  44. ncbi Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic
    K Sankaranarayanan
    Department of Toxicogenetics, Leiden University Medical Centre, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Mutat Res 578:333-70. 2005
    ..A third process, single-strand annealing (SSA), which utilizes short direct repeat sequences, is considered a variant of HRR...
  45. pmc Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel
    Eddy Karnabi
    Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System and SUNY Downstate Medical Center, Brooklyn, NY 11209, USA
    J Autoimmun 34:80-6. 2010
    ..CHB) is an autoimmune disease associated with autoantibodies against intracellular ribonucleoproteins SSB/La and SSA/Ro. The hallmark of CHB is complete atrioventricular block...
  46. ncbi Autoimmune response in mothers of children with congenital and postnatally diagnosed isolated heart block: a population based study
    Heikki Julkunen
    Department of Internal Medicine, Peijas Hospital, Helsinki University Hospital, Vantaa, Finland
    J Rheumatol 31:183-9. 2004
    ..To study the autoimmune response in mothers of children with isolated congenital heart block (CHB) and heart block (HB) diagnosed postnatally...
  47. pmc Anti-Ro/SSA and anti-La/SSB autoantibodies in the tear fluid of patients with Sjögren's syndrome
    E Toker
    Department of Ophthalmology, Marmara University, School of Medicine, Marmara, Turkey
    Br J Ophthalmol 88:384-7. 2004
    To investigate the presence of anti-Ro/SSA and anti-La/SSB antibodies in the tear fluid and serum of patients with Sjögren's syndrome and to evaluate the association of these autoantibodies with the severity of keratoconjunctivitis sicca.
  48. ncbi Periorbital cutaneous neonatal lupus
    Rani M Cooper
    Department of Medicine, Division of Dermatology, Scott and White Memorial Hospital and Clinic, 409 Adams Street, Temple, TX 76508, USA
    Skinmed 6:145-6. 2007
    ..Laboratory studies revealed normal complete blood cell count, normal liver function tests, strongly positive anti-SSA antibody at 118 units (>80 units, strongly positive), and a negative anti-SSB antibody...
  49. doi Single-strand annealing, conservative homologous recombination, nonhomologous DNA end joining, and the cell cycle-dependent repair of DNA double-strand breaks induced by sparsely or densely ionizing radiation
    Marlis Frankenberg-Schwager
    University of Goettingen, Radiology Center, Department of Nuclear Medicine, 37075 Goettingen, Germany
    Radiat Res 171:265-73. 2009
    The cell cycle-dependent relative contributions of error-prone single-strand annealing (SSA), error-free conservative homologous recombination (HR), and potentially error-prone nonhomologous DNA end joining (NHEJ) to repair simple (..
  50. ncbi Detection of anti-SSA antibodies by indirect immunofluorescence
    Xavier Bossuyt
    Laboratory Medicine and Internal Medicine, University Hospital Leuven, Leuven, Belgium
    Clin Chem 50:2361-9. 2004
    HEp-2 cells that overexpress the human 60-kDa SSA antigen have been used to improve sensitivity and specificity for the detection of anti-SSA antibodies by indirect immunofluorescence...
  51. ncbi Fetal echocardiographic assessment of endocardial fibroelastosis in maternal anti-SSA antibody-associated complete heart block
    Hisaaki Aoki
    Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
    Circ J 75:1215-21. 2011
    There are few reports describing the features of maternal anti-SSA antibody-associated congenital complete heart block (CCHB) patients developing endocardial fibroelastosis (EFE)...
  52. ncbi Skin sympathetic nerve activity and effector function during sleep in humans
    G Noll
    Department of Clinical Neurosciences, Sahlgren Hospital, University of Goteborg, Sweden
    Acta Physiol Scand 151:319-29. 1994
    Multi-unit sympathetic skin nerve activity (SSA) in the peroneal nerve was recorded together with electrical skin resistance, skin blood flow and (in some subjects) finger blood pressure during sleep in 22 sleep-deprived healthy subjects...
  53. ncbi Anti-Ro/SSA antibodies in rheumatoid arthritis: clinical and immunologic associations
    I Cavazzana
    Clinical Immunology Unit and Chair, Spedali Civili, Brescia, Italy
    Clin Exp Rheumatol 24:59-64. 2006
    To assess the prevalence of anti-Ro/SSA in RA and to analyse clinical and serological features of anti-Ro/SSA positive patients with RA.
  54. doi MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6
    Joanna A Gibson
    Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 35:742-9. 2011
    ..One previously published study suggested that expression of MUC6 is specific for sessile serrated adenoma/polyps (SSA/Ps) and thus can be used to distinguish these lesions from hyperplastic polyps (HPs)...
  55. ncbi Comparison of Multistix PRO dipsticks with other biochemical assays for determining urine protein (UP), urine creatinine (UC) and UP:UC ratio in dogs and cats
    Elizabeth G Welles
    Department of Pahology, Auburn University, AL, USA
    Vet Clin Pathol 35:31-6. 2006
    ..A dipstick that measures urine protein, urine creatinine, and UP:UC ratio has been used in human medicine and could have application for veterinary practice...
  56. doi Utility of cardiac monitoring in fetuses at risk for congenital heart block: the PR Interval and Dexamethasone Evaluation (PRIDE) prospective study
    Deborah M Friedman
    Department of Pediatrics, Saint Barnabas Medical Center, Livingston, NJ, USA
    Circulation 117:485-93. 2008
    Anti-SSA/Ro-associated third-degree congenital heart block is irreversible, prompting a search for early markers and effective therapy.
  57. pmc Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Cancer 8:33. 2008
    ..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway...
  58. doi Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Biother Radiopharm 25:237-43. 2010
    Somatostatin analogs (SSA) are the standard diagnostic and treatment tools in the clinical management of patients with neuroendocrine tumors (NETs) expressing somatostatin receptors (SSTRs)...
  59. ncbi Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry
    J P Buyon
    Department of Rheumatology and Medicine, Hospital for Joint Diseases, New York University School of Medicine, New York 10003, USA
    J Am Coll Cardiol 31:1658-66. 1998
    ..The present study describes the demographics, mortality, morbidity and recurrence rates of autoimmune-associated congenital heart block (CHB) using information from the Research Registry for Neonatal Lupus...
  60. ncbi Transgenic Trifolium repens with foliage accumulating the high sulphur protein, sunflower seed albumin
    P Christiansen
    DLF Trifolium, Danish Plant Breeding, Denmark
    Transgenic Res 9:103-13. 2000
    ..acids cysteine and methionine in Trifolium repens, we introduced the coding sequence of the sunflower seed albumin (SSA) into T. repens by Agrobacterium tumefaciens-mediated transformation...
  61. ncbi The Sclerotinia sclerotiorum agglutinin represents a novel family of fungal lectins remotely related to the Clostridium botulinum non-toxin haemagglutinin HA33/A
    Els J M Van Damme
    Department of Molecular Biotechnology, Lab Biochemistry and Glycobiology, Ghent University, Coupure Links 653, 9000, Ghent, Belgium
    Glycoconj J 24:143-56. 2007
    ..sclerotiorum agglutinin (SSA) was analyzed...
  62. doi Prevention of congenital heart block in children of SSA-positive mothers
    A Brucato
    Internal Medicine, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
    Rheumatology (Oxford) 47:iii35-7. 2008
    ..and methylprednisolone) are recommended only for maternal indications, not for prevention of CHB in anti-Ro/SSA-positive women...
  63. doi Medical therapy in patients with acromegaly: predictors of response and comparison of efficacy of dopamine agonists and somatostatin analogues
    M Sherlock
    Division of MedicalSciences, Centre for Endocrinology, Diabetes, and Metabolism, University of Birmingham, Birmingham, United Kingdom
    J Clin Endocrinol Metab 94:1255-63. 2009
    ..Acromegaly is associated with increased morbidity and mortality. Treatment options include surgery, radiotherapy, and medical therapy...
  64. doi KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype
    Kyoung Mee Kim
    Department of Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea
    Am J Surg Pathol 34:667-75. 2010
    ..studies, have not been shown to have a strong association with hyperplastic polyp (HPP) or sessile polyp adenoma (SSA) precursor lesions...
  65. ncbi Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group
    Nathalie Costedoat-Chalumeau
    Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 50:3187-94. 2004
    ..and prolongation of the corrected QT (QTc) interval have been reported in infants born to mothers with anti-SSA antibodies...
  66. ncbi Autoimmune-associated congenital heart block: treatment of the mother with immunoadsorption
    Heiko Hickstein
    Department of Nephrology, University of Rostock, Rostock, Germany
    Ther Apher Dial 9:148-53. 2005
    Autoimmune-associated congenital heart block (CHB) is a rare complication of pregnancy in mothers with Anti-Ro/SSA antibodies (SSA-abs), resulting in fetal myocarditis, atrioventricular block, hydrops fetalis and/or intrauterine fetal ..
  67. ncbi Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions
    Atsuko Adachi
    Department of Dermatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan
    Dermatology 214:85-8. 2007
    ..It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan. However, the etiology of these drug eruptions caused by FU agents has not been clarified yet...
  68. doi Is there a link between the human TRIM21 and Trypanosoma cruzi Clone 36 genes in Chagas' disease?
    Martin A Winkler
    Biotech Advisor, 1995 Via Tesoro, Las Cruces, NM 88005 8211, USA
    Mol Immunol 48:365-7. 2010
    The homology between TRIM21 and Trypanosoma cruzi Antigen Clone 36 nucleotide sequence was discovered in 1998 (Winkler et al., Parasite 5, 94-95) prior to the functions of Ro52, the TRIM21 protein product, being understood...
  69. ncbi Adult heart block is associated with disease activity in primary Sjögren's syndrome
    B M Lodde
    Gene Therapy and Therapeutics Branch National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 1190, USA
    Scand J Rheumatol 34:383-6. 2005
    ..block occurring in the foetus and neonate may be associated with maternal anti-SS-A/anti-SS-B autoantibodies (anti-SSA/anti-SSB)...
  70. ncbi The in vitro immunomodulatory effects of sulfasalazine on human polymorphonuclear leukocytes, mononuclear cells, and cultured glomerular mesangial cells
    C Y Tsai
    Department of Medicine, Taipei Veterans General Hospital, Taiwan
    Life Sci 67:1149-61. 2000
    Sulfasalazine (SSA) was investigated for its effects on phagocytic activity of normal human polymorphonuclear neutrophils (PMN), proliferation of mononuclear cells (MNC) and cultured glomerular mesangial cells...
  71. pmc New coupled-particle light-scattering assay for detection of Ro/SSA (52 and 60 kilodaltons) and La/SSB autoantibodies in connective tissue diseases
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Via N Sauro 25, 30027 S Donà di Piave, Italy
    Clin Diagn Lab Immunol 8:922-5. 2001
    ..coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated...
  72. ncbi Background radioactivity in sediments near Los Alamos, New Mexico
    Stephen G McLin
    Water Quality and Hydrology Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Sci Total Environ 328:143-59. 2004
    ..from reservoir sediments are independent of clay content, total organic carbon/specific surface area (TOC/SSA) and cation exchange capacity/specific surface area (CEC/SSA) ratios...
  73. doi Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block
    Linn S Strandberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Immunol 185:3574-82. 2010
    Congenital heart block develops in fetuses of anti-Ro52 Ab-positive women...
  74. ncbi Fetal treatment of congenital heart block ascribed to anti-SSA antibody: case reports with observation of cardiohemodynamics and review of the literature
    H Yamada
    Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Reprod Immunol 42:226-32. 1999
    Maternal anti-SSA(B) antibody crosses the placenta and causes fetal myocarditis, congenital heart block (CHB), hydrops fetalis, and intrauterine fetal death...
  75. ncbi Utilizing multiple vital status tracing services optimizes mortality follow-up in large cohort studies
    L C Schall
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 11:292-6. 2001
    ..two-stage vital status tracing protocol, Pension Benefit Information Company (PBI), Social Security Administration (SSA), and the Health Care Financing Administration (HCFA), with respect to death identification and confirmation rate, ..
  76. ncbi [The role of the sarcocyst surface apparatus in utilizing the host cell muscle structures]
    A I Radchenko
    Institute of Cytology, RAS, St Petersburg
    Tsitologiia 45:443-9. 2003
    The participation of the sarcocyst surface apparatus (SSA) of two sarcosporidian species, Sarcocystis muris and S. ovifelis (Coccidia, Sporozoa, Apicomplexa), in degradation of disrupted host cell substances was investigated...
  77. ncbi Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA)
    Emina Emilia Torlakovic
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
    Am J Surg Pathol 32:21-9. 2008
    ..The distinction between sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA) may be difficult using currently available criteria mostly based on ..
  78. doi Low air levels of benzene: correlation between biomarkers of exposure and genotoxic effects
    Maria Enrica Fracasso
    Department of Medicine and Public Health, Pharmacology Section, University of Verona, Policlinico GB Rossi, P le Scuro 10, 37134 Verona, Italy
    Toxicol Lett 192:22-8. 2010
    ..Benzene exposure was measured in 33 petrochemical industry operators (PIO), 28 service station attendants (SSA), 21 gasoline pump maintenance workers (GPMW) and 51 non-exposed controls by GC-FID analysis...
  79. pmc First do no harm: the impact of recent armed conflict on maternal and child health in Sub-Saharan Africa
    Bernadette A M O'Hare
    Department of Paediatrics, University Hospital of Wales, Cardiff, Heath Park, Cardiff CF14 4XN
    J R Soc Med 100:564-70. 2007
    ..To summarize the amount spent on SALW and the main legal suppliers to countries in Sub-Saharan African countries (SSA), and to summarize licensed production of Small Arms and Light Weapons (SALW) in these countries.
  80. doi Quantitative assessment of antibodies to ribonucleoproteins in primary Sjögren syndrome: correlation with B-cell biomarkers and disease activity
    S Candon
    INSERM U580, Hopital Necker Enfants Malades, Paris, France
    Ann Rheum Dis 68:1208-12. 2009
    To assess the added value of using a radioligand assay (RLA) compared with ELISA to detect antibodies to SSA, SSB and RNP, and to analyse the correlation between autoantibody levels, B-cell biomarkers and disease activity.
  81. doi [HIV infection in immigrants in Spain: Epidemiological characteristics and clinical presentation in the CoRIS Cohort (2004-2006)]
    Ana María Caro-Murillo
    Centro Nacional de Epidemiologia, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, Madrid, Espana
    Enferm Infecc Microbiol Clin 27:380-8. 2009
    ..We describe the sociodemographic, epidemiological, and clinical characteristics of a cohort of naïve HIV-infected subjects (CoRIS cohort) according to their place of origin...
  82. ncbi Quantitative anatomic evaluation of cervical lateral mass fixation with a comparison of the Roy-Camille and the Magerl screw techniques
    Cédric Barrey
    Department of Neurosurgery, Hôpital Neurochirurgical P Wertheimer, Lyon, France
    Spine (Phila Pa 1976) 30:E140-7. 2005
    ..An anatomic and computed tomography (CT) study of the Roy-Camille and the Magerl techniques with quantitative comparison of the safety zones of the two surgical techniques...
  83. ncbi The epidemiology of nevi and signs of skin aging in the adult general population: Results of the KORA-survey 2000
    Torsten Schafer
    Institute of Social Medicine, Medical University of Luebeck, Luebeck, Germany
    J Invest Dermatol 126:1490-6. 2006
    Nevi can approximate the melanoma risk and demographic changes will increase the meaning of signs of skin aging (SSA). However, little is known about the epidemiology of nevi and SSA in the general adult population...
  84. ncbi [Suppression effect of different stage antigens of Schistosoma japonicum on airway inflammation in a murine model of asthma]
    Zi Wei Jiang
    Department of Pathogenic Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 26:428-31, 437. 2008
    ..To investigate the effect of antigens of different stage Schistosoma japonicum on airway inflammation in a murine model of asthma...
  85. pmc Antibodies to amino acid 200-239 (p200) of Ro52 as serological markers for the risk of developing congenital heart block
    L Strandberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Exp Immunol 154:30-7. 2008
    Maternal autoantibodies to the p200-epitope of Ro52 have been suggested to correlate with development of congenital heart block...
  86. doi Longitudinal outcome study of sessile serrated adenomas of the colorectum: an increased risk for subsequent right-sided colorectal carcinoma
    Fang I Lu
    Department of Pathology and Laboratory Medicine, University of British Columbia Faculty of Medicine, Vancouver, Canada
    Am J Surg Pathol 34:927-34. 2010
    ..We studied the natural history of SSA by analyzing the outcome of previously undiagnosed SSAs and comparing it with that of hyperplastic polyps (HPs) and ..
  87. ncbi Cutis marmorata telangiectatica congenita or neonatal lupus?
    J M Carrascosa
    Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona Badalona, Spain
    Pediatr Dermatol 13:230-2. 1996
    ..An infant girl was noted at birth to have characteristic features of CMTC as well as anti-Ro/SSA antibodies and a positive autonuclear antibody (ANA) test...
  88. pmc Members of the Hsp70 family of proteins in the cell wall of Saccharomyces cerevisiae
    J L Lopez-Ribot
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
    J Bacteriol 178:4724-6. 1996
    Western blot (immunoblot) analysis of cell wall and cytosolic extracts obtained from parental and ssa1 and ssa2 single- and double-mutant strains of Saccharomyces cerevisiae showed that the heat shock protein 70 (Hsp70) products of these ..
  89. ncbi Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus
    R Hal Scofield
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Trends Immunol 25:1-3. 2004
    ..These data add to the expanding cooperation between mouse and human SLE genetic studies and are the first in which ablation of an autoantigen induces an autoimmune disease...
  90. ncbi First-degree heart block in the fetus of an anti-SSA/Ro-positive mother: reversal after a short course of dexamethasone treatment
    Samo Vesel
    Department of Pediatrics, Cardiology, Unit, University Medical Center Ljubljana, Ljubljana, Slovenia
    Arthritis Rheum 50:2223-6. 2004
    Isolated congenital heart block is almost invariably associated with the presence of antibodies to SSA/Ro and SSB/La antigens in the maternal circulation. Once established, third-degree congenital heart block is permanent...
  91. ncbi Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52
    Janosch Hennig
    Molecular Biotechnology, IFM, Campus Valla, Linkoping University, S 581 83 Linkoping, Sweden
    J Biol Chem 280:33250-61. 2005
    b>Ro52 is one of the major autoantigens targeted in the autoimmune disease Sjögren syndrome. By sequence similarity, Ro52 belongs to the RING-B-box-coiled-coil (RBCC) protein family...
  92. ncbi The egocentric reference deviation of neglect patients is influenced by visuospatial attention
    Christelle Richard
    Service de Rééducation Neurologique and EA2691, Hôpital Swynghedauw, CHRU de Lille, 59037 Lille Cedex, France
    Neuropsychologia 43:1784-91. 2005
    The right deviation of the subjective straight-ahead (SSA), representing a deviation of the body centered spatial reference frame (egocentric reference), is a frequent phenomenon in spatial neglect...
  93. pmc The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system
    Sae Hun Park
    Institut fuer Biochemie, Universitaet Stuttgart, 70569 Stuttgart, Germany
    Mol Biol Cell 18:153-65. 2007
    ..Degradation requires the ubiquitin-conjugating enzymes Ubc4p and Ubc5p, the cytoplasmic Hsp70 Ssa chaperone machinery, and the Hsp70 cochaperone Ydj1p...
  94. pmc Clinical significance of autoantibodies recognizing Sjögren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren's syndrome
    V Goeb
    Department of Rheumatology, Rouen University Hospital and Inserm U519 IFRMP23, Institute for Biomedical Research, University of Rouen, Rouen, France
    Clin Exp Immunol 148:281-7. 2007
    ..In addition, the presence of anti-nuclear antibodies (ANA), anti-52- and 60-kDa Sjögren's syndrome A (SSA), anti-Sjögren's syndrome B (SSB), anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factors (RF) ..
  95. doi Comparison of urine dipstick, sulfosalicylic acid, urine protein-to-creatinine ratio, and species-specific ELISA methods for detection of albumin in urine samples of cats and dogs
    Shane D Lyon
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:874-9. 2010
    To evaluate the use of dipstick, sulfosalicylic acid (SSA), and urine protein-to-creatinine ratio (UP:C) methods for use in detection of canine and feline albuminuria.
  96. pmc Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block
    Paraskevi Briassouli
    Department of Medicine, New York University School of Medicine, New York, 10016, USA
    Circ Res 107:374-87. 2010
    ....
  97. pmc Singular Spectrum Analysis of Gene Expression Profiles of Early Drosophila embryo: Exponential-in-Distance Patterns
    T Alexandrov
    Center for Industrial Mathematics, Department of Mathematics, University of Bremen, 28334 Bremen, Germany
    Res Lett Signal Process 2008:. 2008
    We present investigation of gene expression profiles by means of singular spectrum analysis (SSA)...
  98. pmc Functional impairment in people with schizophrenia: focus on employability and eligibility for disability compensation
    Philip D Harvey
    University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 1450, Miami, FL 33136, USA
    Schizophr Res 140:1-8. 2012
    The Social Security Administration (SSA) is considering whether schizophrenia may warrant inclusion in their new "Compassionate Allowances" process, which aims to identify diseases and other medical conditions that invariably quality for ..
  99. doi Comparison of urine dipstick, sulfosalicylic acid, urine protein-to-creatinine ratio and a feline-specific immunoassay for detection of albuminuria in cats with chronic kidney disease
    Andrew S Hanzlicek
    Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Feline Med Surg 14:882-8. 2012
    The performance of the urine dipstick, sulfosalicylic acid (SSA), and urine protein-to-creatinine (UPC) tests for the detection of albuminuria was assessed in cats with chronic kidney disease (CKD)...
  100. doi Autoantibodies to the Rpp25 component of the Th/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests
    Michael Mahler
    From INOVA Diagnostics Inc, San Diego, California, USA the Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kita Kyushu, Japan Division of Rheumatology and Clinical Immunology, Department of Medicine, and Pathology, Immunology and Laboratory Medicine, and the Department of Oral Biology, University of Florida, Gainesville, Florida, USA Department of Medicine, McGill University the Division of Rheumatology and Lady Davis Institute, Jewish General Hospital, Montreal, Quebec the Department of Medicine, University of Calgary, Calgary, Alberta, Canada M Mahler, PhD, INOVA Diagnostics Inc M Satoh, MD, PhD, Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, and Division of Rheumatology and Clinical Immunology, Department of Medicine, and Pathology, Immunology and Laboratory Medicine, University of Florida M Hudson, MD, Department of Medicine, McGill University, Division of Rheumatology and Lady Davis Institute, Jewish General Hospital M Baron, MD, Department of Medicine, McGill University, and Division of Rheumatology, Jewish General Hospital J Y F Chan E K L Chan
    J Rheumatol 41:1334-43. 2014
    ..e., centromere, topoisomerase I, RNA polymerase III, PM/Scl, Ro52/TRIM21, and U1RNP). Ribonuclease P protein subunit p25, (Rpp25) is an autoantigenic component of the Th/To complex...
  101. doi Seeking greener pastures? The relationship between career satisfaction and the intention to emigrate: a survey of Ghanaian physicians
    Samuel T Opoku
    Department of Health Services Research and Administration, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198 4350, USA
    Int Health 6:208-12. 2014
    ..to crippling the health systems of developing nations, the emigration of physicians from sub-Saharan African (SSA) countries results in a loss of return on investment to these nations...

Research Grants69

  1. DEATH RATES AND DEATH DATA FOR ASIAN AMERICAN ELDERLY
    Diane Lauderdale; Fiscal Year: 2003
    ..data source for numerators and denominators, the Master Beneficiary Record at the Social Security Administration (SSA)...
  2. JILL PAMELA BUYON; Fiscal Year: 2015
    ..certainty that the mother, who may have a rheumatic disease or be asymptomatic, will have autoantibodies (Ab) to SSA/Ro ribonucleoproteins...
  3. CELLULAR MECHANISMS OF AUTOIMMUNE ASSOCIATED CONGENITAL
    Mohamed Boutjdir; Fiscal Year: 1999
    ..of affected infants frequently had autoimmune diseases and in particular many maternal sera contained antibodies to SSA/Ro and SSB/La ribonucleoproteins...
  4. RESEARCH REGISTRY FOR NEONATAL LUPUS
    JILL PAMELA BUYON; Fiscal Year: 2010
    Neonatal lupus is a disease seen in babies born to mothers who have antibodies to SSA/Ro and/or SSB/La proteins. The mother may have systemic lupus erythematosus, Sjogren's syndrome, or be otherwise healthy...
  5. RESEARCH REGISTRY FOR NEONATAL LUPUS
    JILL PAMELA BUYON; Fiscal Year: 2009
    Neonatal lupus is a disease seen in babies born to mothers who have antibodies to SSA/Ro and/or SSB/La proteins. The mother may have systemic lupus erythematosus, Sjogren's syndrome, or be otherwise healthy...
  6. A MODEL OF SJOGREN'S SYNDROME WITH ANTI-RO/LA ANTIBODIES
    R Scofield; Fiscal Year: 2001
    ..The great majority of patients have antibodies binding one or more components of the Ro/LA (or SSA/SSB) ribonucleoprotein particle, which is found in every mammalian cell type examined and whose function is not ..
  7. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    ..lupus erythematosus, Sjogrens syndrome, or be entirely asymptomatic) lead to the production of antibodies to the SSA/Ro-SSB/La ribonucleoproteins which cross the placenta and presumably injure the developing fetus...
  8. GLENN JOHN WAGNER; Fiscal Year: 2015
    ..has become increasingly prominent among persons living with HIV/AIDS (PLHA), especially in sub-Saharan Africa (SSA) where fertility is a strong cultural value...
  9. Role of Ca channels in congenital heart block
    Mohamed Boutjdir; Fiscal Year: 2007
    ..newborn of mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48kD SSB/La, 52kD SSA/Ro, and 60kD SSA/Ro...
  10. Georgette D Kanmogne; Fiscal Year: 2016
    ..However, two-thirds of the 33.4 million people living with HIV/AIDS are in sub-Saharan Africa (SSA) and are infected with non-B HIV subtypes, including recombinant viruses...
  11. William W Latimer; Fiscal Year: 2014
    A 2008 UNAIDS report indicates that Sub Saharan Africa (SSA) accounts for only 10% of the world[unreadable]s population but 68% of adults and children living with HIV/AIDS with South Africa (5...
  12. Wafaa M El-Sadr; Fiscal Year: 2014
    ..Linkage and retention rates in HIV programs in Sub-Saharan Africa (SSA) are suboptimal, with less than half of patients who test positive successfully linking and remaining in care at 1 ..
  13. Lisa F Berkman; Fiscal Year: 2016
    DESCRIPTION (provided by the applicant): Over the last decades, countries in Sub-Saharan Africa (SSA) have experienced a demographic and epidemiological transition with declines in mortality from infectious diseases and increases in the ..
  14. Family-Based Prevention of Mental Health Problems in HIV/AIDS Affected Children
    Theresa Stichick Betancourt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): High HIV/AIDS prevalence in the Sub Saharan Africa (SSA) region has resulted in large numbers of children affected by HIV/AIDS through HIV infection, HIV+ caregivers who are ill, and family deaths ..
  15. Social Cash Transfers, Household Risk and HIV Prevention in Kenya
    Sudhanshu Handa; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Two-thirds of the estimated 33m people infected with HIV live in sub-Saharan Africa (SSA)...
  16. Jenny A Trinitapoli; Fiscal Year: 2016
    ..to antiretroviral therapy (ART) and policies around HIV treatment are expanding throughout sub- Saharan Africa (SSA)...
  17. Olugbenga G Ogedegbe; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Ghana and other countries in sub-Saharan Africa (SSA) are experiencing an epidemic of cardiovascular diseases (CVD) propelled by rapidly increasing rates of hypertension...
  18. Michal A Olszewski; Fiscal Year: 2016
    ..neoformans, and the role of recently defined virulence factor, heat shock protein Ssa1 in this porcess...
  19. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    Jill Buyon; Fiscal Year: 2007
    The association of congenital heart block (CHB) with autoantibodies to SSA/Ro and SSB/La approaches the predictable...
  20. Jaco Homsy; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): In sub-Saharan Africa (sSA), the vast majority of the millions of pregnant women who are tested and counseled for HIV every year test negative for HIV antibodies...
  21. PAULA LOUISE FISCHHABER; Fiscal Year: 2016
    ..of DNA sequence homology flanking the DSB site, 2) whether Rad10 recruitment in the "single-strand annealing" (SSA) mode of DSB repair is dependent on the SAW1 gene, and whether Rad10 and Saw1 proteins colocalize at SSA repair ..
  22. GBENGA GODWIN OGEDEGBE; Fiscal Year: 2015
    ..It is estimated that the scant resources in Ghana and other Sub- Saharan African (SSA) countries would be depleted by the disability from cardiovascular-related complications in the next decade if this ..
  23. TRIM Interactions with Arthritic Alphaviruses
    Mark T Heise; Fiscal Year: 2013
    ..or exacerbation of alphavirus-induced inflammatory arthritis and found that several TRIM family members, including TRIM21 and TRIM34 were significantly upregulated in the joints of mice suffering from either RRV or CHIKV- induced ..
  24. Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis
    Flora Sam; Fiscal Year: 2011
    ..e. amyloidosis associated with wild-type transthyretin (TTR): the senile systemic amyloidosis (SSA) or a mutant transthyretin (ATTR);the prognosis for patients with AL-CMP is inordinately worse...
  25. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2013
    ..extracellular deposits of amyloid in the heart, pathology referred to as Senile Systemic (or Cardiac) Amyloidosis (SSA)...
  26. Sandra K Weller; Fiscal Year: 2016
    ..that DDR proteins function in at least four pathways, three that require some amount of homology (A-NHEJ, HR and SSA) and one that does not (C-NHEJ)...
  27. Curt H Hagedorn; Fiscal Year: 2014
    ..Serrated polyps are divided into two main subtypes: sessile serrated adenomas/polyps (SSA/Ps) and traditional hyperplastic polyps...
  28. PAMELA JAGGER; Fiscal Year: 2016
    ..of fuel and technology use and their associated health and socioeconomic outcomes in sub-Saharan Africa (SSA)...
  29. MicroRNA, sulindac, and breast cancer chemoprevention
    Yaguang Xi; Fiscal Year: 2013
    ..in response to treatment with SS and a more active, non-COX-inhibitory SS derivative, sulindac sulfide amide (SSA), which we recently found to inhibit mammary tumorigenesis in the DMBA rat model...
  30. KEVIN ANTHONY MORANO; Fiscal Year: 2015
    ..that while the NEFs share a common ability to stimulate Hsp70 activity, they differentially interact with the Ssa and Ssb families of cytosolic Hsp70 to promote protein folding and repair...
  31. Gary A Piazza; Fiscal Year: 2015
    ..a series of derivatives that were synthesized and screened, a novel compound referred to as sulindac sulfide amide (SSA) was identified that potently inhibits colon tumor cell proliferation (IC50 = 1mM), selectively induces apoptosis ..
  32. FRED M SSEWAMALA; Fiscal Year: 2016
    ..Studies from Uganda, and much of sub-Saharan Africa (SSA) indicate that one group disproportionately affected by HIV is economically vulnerable children...
  33. Saliva Analyzer for Diagnosing SRD Patient Drug Use
    Stuart Farquharson; Fiscal Year: 2012
    ..The proposed SERS Saliva Analyzer (SSA) will meet all such requirements by providing health care personnel an easy-to-use device, which will extract, ..
  34. Gary A Piazza; Fiscal Year: 2016
    ..Sulindac sulfide amide (SSA) displayed adequate oral bioavailability and appeared to be less toxic than sulindac in mice...
  35. Candida Invasion of Endothelium and Virulence
    Scott G Filler; Fiscal Year: 2013
    ..albicans;2) determine the mechanisms by which C. albicans Ssa1 contributes to endothelial cell invasion and virulence;3) use C...
  36. GLENN JOHN WAGNER; Fiscal Year: 2014
    ..health fronts, and the relative absence of depression treatment in HIV care programs throughout sub-Saharan Africa (SSA) despite our observed efficacy of antidepressants with persons living with HIV/AIDS (PLHA), the proposed project ..
  37. Boys Transitions Through Puberty
    Marni Sommer; Fiscal Year: 2012
    ..through puberty and young adulthood are factors associated with high risk of HIV in sub-Saharan Africa (SSA)...
  38. Characterization of chaperone-prion specificity in Saccharomyces cerevisiae
    JUSTIN KEITH HINES; Fiscal Year: 2010
    ..on the three proteins which form a specific regulatory interaction in [RNQ+] prion maintenance: chaperones Sis1 and Ssa1, and the prion protein Rnq1. The specific aims are: 1...
  39. JUSTIN WILLIAM CHARTRON; Fiscal Year: 2015
    ..The assay will also be used to describe the partial rescue of SSB deletion by the major cytosolic Hsp70 homologs, SSA, and whether this rescue is also NAC-mediated...
  40. Improving Clinician Ratings of Money Mismanagement: Addiction's Impact.
    Marc I Rosen; Fiscal Year: 2013
    ..payee may be assigned to patients who are incapable of managing their funds but the Social Security Administration (SSA) largely decides on payee assignment based on a single question answered by the patient's clinician...
  41. Sebastian Linnemayr; Fiscal Year: 2016
    ..adherence that has been found lower than previously assumed and declining over time in sub-Saharan Africa (SSA). Youths with still developing emotional and cognitive capacities face special and unique challenges to adherence...
  42. Sylvia Meek; Fiscal Year: 2016
    ..and program planners ensuring strategic information is disseminated and shared among GMS and sub-Saharan Africa (SSA), and best practices harmonized in the region...
  43. Lisa Michelle Butler; Fiscal Year: 2015
    ..1 million children under the age of 15 years living with HIV, with almost 90% residing in sub-Saharan Africa (SSA)...
  44. Ralph Scully; Fiscal Year: 2014
    ..response to a mammalian DSB encodes additional DSB repair functions, regulating both single strand annealing (SSA) and non-homologous end joining (NHEJ)...
  45. ANNA L MALKOVA; Fiscal Year: 2016
    ..to propose that chromatid fusions can be stimulated by DSBs by allowing inter-molecular single-strand annealing (SSA) between inverted DNA repeats (IRs)...
  46. Oyewusi Gureje; Fiscal Year: 2016
    ..hub is aimed at creating an infrastructure to develop mental health (MH) research capacity in Sub-Saharan Africa (SSA) and to advance global MH science by conducting innovative public health-relevant MH research in the region...
  47. Keng Yen Huang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Children in Sub-Saharan-Africa (SSA) are burdened by significant unmet mental health needs, but this region has limited access to mental health workers and resources to address these needs...
  48. THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL
    Barry Davis; Fiscal Year: 2012
    ..Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.
  49. THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL
    Barry Davis; Fiscal Year: 2013
    ..Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.
  50. THE ANTIHYPERTENSIVE AND LIPID-LOWERING TO PREVENT HEART ATTACK TRIAL RENEWAL
    Barry Davis; Fiscal Year: 2011
    ..Medicare and Medicaid Services (CMS), United States Renal Data System (USRDS), and Social Security Administration (SSA). The contract renewal will extend the passive follow up for an additional five years through 2016.
  51. MICHAEL STEPHEN GLICKMAN; Fiscal Year: 2016
    ..By using a newly developed assay of chromosomal DSB repair that discriminates HR, NHEJ and single-strand annealing (SSA) pathways, we will determine the relative frequency of pathway use, molecular outcomes, and effects of DSB end-..
  52. Mayowa Ojo Owolabi; Fiscal Year: 2016
    ..prevention strategies for limiting the immense personal and societal burden of stroke in Sub-Saharan Africa (SSA) is contingent on a better understanding of the predisposing risk factors for stroke in the region, which may not ..
  53. Research Access to Death Records Contract Number: NIH Proposal #10001666 CAN 8
    JILL COLLAMORE; Fiscal Year: 2013
    ..2011 it was learned that details in the Social Security Act restricted access to the complete DMF, prohibiting SSA from disclosing state provided death records...
  54. An Interdisciplinary Approach to Malaria Burden in Sub-Saharan Africa
    Juliet Iwelunmor; Fiscal Year: 2010
    ..expertise in international research and fieldwork experience in a malaria endemic country in Sub-Saharan Africa (SSA)...
  55. BECKY LYNN GENBERG; Fiscal Year: 2016
    ..provided by applicant): The expansion of access to antiretroviral therapies (ART) in sub-Saharan Africa (SSA) has resulted in dramatic reductions in HIV-related morbidity and mortality...
  56. Claudia A Hawkins; Fiscal Year: 2016
    ..Despite the high burden of HIV/HBV co- infection in sub-Saharan Africa (SSA), there has been very little study of liver disease in HIV/HBV co-infected individuals in these settings...
  57. DOUGLAS LOWELL MANN; Fiscal Year: 2016
    ..an early-phase randomized clinical trial (RCT) in patients with type 2 diabetes (T2D) and DHF, using a salsalate (SSA), an anti-inflammatory agent that improves glycemic control in T2D...
  58. Migration and Health in Malawi
    Hans Peter Kohler; Fiscal Year: 2013
    ..migration and health research has typically focused on Asia, Europe or North America instead of sub-Saharan Africa (SSA), despite the impact of the HIV/AIDS epidemic on migration patterns, and the high and increasing rates of internal ..
  59. John P Rotrosen; Fiscal Year: 2015
    ..We continue to engage leaders of very large systems, including the NY State SSA (OASAS) and the NY City Health and Hospitals Corporation, as well as the NeATTG, as members of our Executive ..
  60. Polyamine metabolism in heart and kidney ischemic injury
    Manoocher Soleimani; Fiscal Year: 2005
    ..We further hypothesize that enhanced expression of SSA T in kidney or heart leads to cell damage through depletion of polyamines, production of toxic metabolites (e.g...
  61. Synthesis of HRS-SSA linked data
    LARS VILHUBER; Fiscal Year: 2007
    ..Under current HRS protocols, the use of the SSA data is restricted...
  62. STRUCTURAL AND FUNCTIONAL STUDIES OF HSP40
    Bingdong Sha; Fiscal Year: 2010
    ..hypothesis, we intend to determine the crystal structure of the yeast type II Hsp40 Sis1 complexed with yeast Hsp70 Ssa1. We have constituted and crystallized the protein complex of Sis1 peptide-binding fragment and the Ssal C-terminal ..
  63. Array Tomographic Single-Synapse Analysis of Normal and Disordered Cortex
    Stephen Smith; Fiscal Year: 2009
    ..tomographic molecular labeling and image analysis methods, called Array Tomographic Single-Synapse Analysis (AT/SSA), will be developed for the purpose of quantifying and classifying individual synapses in tissues of mouse and ..
  64. SUPERANTIGENS AND THE MHC--STRUCTURE AND FUNCTION
    Richard Cook; Fiscal Year: 2000
    ..members of this family, the staphylococcal enterotoxins SEA, SEB and SEE and the related streptococcal superantigen SSA, which we isolated and characterized during the initial period of support...
  65. Pension Wealth Calculators for Employer-Provided Plans
    GARY ENGELHARDT; Fiscal Year: 2004
    ..is the integration and use of administrative covered earnings and W-2 data from the Social Security Administration (SSA)...