TREM2

Summary

Gene Symbol: TREM2
Description: triggering receptor expressed on myeloid cells 2
Alias: TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2a
Species: human

Top Publications

  1. pmc Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
    Juha Paloneva
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:656-62. 2002
  2. pmc DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features
    Juha Paloneva
    Biomedicum National Public Health Institute, Department of Molecular Medicine, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Exp Med 198:669-75. 2003
  3. doi Mutations in TREM2 lead to pure early-onset dementia without bone cysts
    Eliane Chouery
    Genetic Medical Unit, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
    Hum Mutat 29:E194-204. 2008
  4. pmc A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    A Bouchon
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 194:1111-22. 2001
  5. doi TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
    Stefanie Frank
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Glia 56:1438-47. 2008
  6. doi The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
    Luisa Stefano
    Vita Salute San Raffaele University, Center of Excellence in Cell Development, Milan, Italy
    J Neurochem 110:284-94. 2009
  7. pmc Variant of TREM2 associated with the risk of Alzheimer's disease
    Thorlakur Jonsson
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 368:107-16. 2013
  8. pmc TREM2 variants in Alzheimer's disease
    Rita Guerreiro
    University College London UCL Institute of Neurology, London, United Kingdom
    N Engl J Med 368:117-27. 2013
  9. pmc Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
    Margarita Giraldo
    Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
    Neurobiol Aging 34:2077.e11-8. 2013
  10. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000

Research Grants

  1. TREM2 regulation of macrophages in spinal cord injury and CNS endogenous repair
    Phillip G Popovich; Fiscal Year: 2013
  2. Midori A Yenari; Fiscal Year: 2014
  3. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
  4. Mary C Nakamura; Fiscal Year: 2016
  5. Nucleosides and TREM2 Mediate Inflammation-Induced Bone Loss
    George Pan; Fiscal Year: 2010
  6. Unraveling the Mystery of Molecular Phagocyte Biology for Microglia
    Wei Li; Fiscal Year: 2013
  7. Steven G Younkin; Fiscal Year: 2016
  8. Carlos Cruchaga; Fiscal Year: 2016
  9. Role of DAP12 in type 1 anti-mycobacterial immunity
    Zhou Xing; Fiscal Year: 2005
  10. Triggering Receptors and CNS Inflammation
    MONICA CARSON; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications234 found, 100 shown here

  1. pmc Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
    Juha Paloneva
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Am J Hum Genet 71:656-62. 2002
    ..Here we complete the molecular pathology of PLOSL by identifying TREM2 as the second PLOSL gene...
  2. pmc DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features
    Juha Paloneva
    Biomedicum National Public Health Institute, Department of Molecular Medicine, Haartmaninkatu 8, 00290 Helsinki, Finland
    J Exp Med 198:669-75. 2003
    ..earlier characterized the molecular genetic background of PLOSL by identifying mutations in two genes, DAP12 and TREM2. DAP12 is a transmembrane adaptor protein that associates with the cell surface receptor TREM2...
  3. doi Mutations in TREM2 lead to pure early-onset dementia without bone cysts
    Eliane Chouery
    Genetic Medical Unit, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
    Hum Mutat 29:E194-204. 2008
    ..40+3delAGG, in the 5' consensus donor splice site in intron 1 of TREM2 gene which is known to be responsible for PLOSL (Polycystic Lipomembranous Osteodysplasia with Sclerosing ..
  4. pmc A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    A Bouchon
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 194:1111-22. 2001
    ..In contrast to Toll-like receptor-mediated signaling, TREM2/DAP12 stimulation is independent of nuclear factor-kappaB and p38 stress-activated protein kinase...
  5. doi TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
    Stefanie Frank
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Glia 56:1438-47. 2008
    ..One of these genes is the microglia-associated triggering receptor expressed on myeloid cells (TREM2) which enhances phagocytosis, but abrogates cytokine production as well as TLR and Fc receptor-mediated induction ..
  6. doi The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor
    Luisa Stefano
    Vita Salute San Raffaele University, Center of Excellence in Cell Development, Milan, Italy
    J Neurochem 110:284-94. 2009
    ..So far, specific agonist(s) of TREM2 have not been identified and its (their) transduction mechanisms are largely unknown...
  7. pmc Variant of TREM2 associated with the risk of Alzheimer's disease
    Thorlakur Jonsson
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 368:107-16. 2013
    ..Few rare variants affecting the risk of late-onset Alzheimer's disease have been found...
  8. pmc TREM2 variants in Alzheimer's disease
    Rita Guerreiro
    University College London UCL Institute of Neurology, London, United Kingdom
    N Engl J Med 368:117-27. 2013
    Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia.
  9. pmc Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
    Margarita Giraldo
    Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia
    Neurobiol Aging 34:2077.e11-8. 2013
    Recent evidence suggests that rare genetic variants within the TREM2 gene are associated with increased risk of Alzheimer's disease...
  10. ncbi Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    A Bouchon
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 164:4991-5. 2000
    ..To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses...
  11. ncbi Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response
    Anna Kiialainen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, 00290, Helsinki, Finland
    J Mol Med (Berl) 85:971-83. 2007
    ..leukoencephalopathy (PLOSL), an early onset dementia with bone fractures caused by mutations in TYROBP (DAP12) and TREM2 genes, which encode important signaling molecules in human dendritic cells (DCs)...
  12. ncbi Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes
    Lorenza Montalbetti
    Department of Neuroscience, University of Pavia IRCCS C Mondino Institute of Neurology Via Mondino, 2 27100 Pavia, Italy
    Funct Neurol 20:71-5. 2005
    ..99mTc-ECD SPECT) and neuropsychological study of healthy members of an Italian family carrying a mutation in the TREM2 gene...
  13. pmc Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
    Laura Piccio
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 131:3081-91. 2008
    b>Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor expressed by microglia and macrophages...
  14. pmc Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
    George D Kalliolias
    Hospital for Special Surgery, New York, NY, USA
    Arthritis Rheum 62:402-13. 2010
    ..This study was undertaken to investigate the effects of IL-27 on human osteoclastogenesis, to determine whether IL-27 can stimulate or attenuate the osteoclast-mediated bone resorption that is a hallmark of RA...
  15. pmc Efficient colonic mucosal wound repair requires Trem2 signaling
    Hiroshi Seno
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:256-61. 2009
    ..This increased epithelial proliferation was coincident with the infiltration of Trem2 expressing macrophages and increased expression of IL-4 and IL-13 in the wound bed...
  16. doi Gene expression profile of the bone microenvironment in human fragility fracture bone
    B Hopwood
    Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Bone 44:87-101. 2009
    ..ST14, CTSB, SPARC, FST, LGALS1, SPP1, ADM, and COL4A1), myelomonocytic differentiation and osteoclastogenesis (TREM2, ANXA2, IL10, CD14, CCR1, ADAM9, CCL2, CTGF, and KLF10), or adipogenesis, lipid and/or glucose metabolism (IL10, ..
  17. pmc Molecular characterization of antigen-peptide pulsed dendritic cells: immature dendritic cells develop a distinct molecular profile when pulsed with antigen peptide
    Amy X Yang
    Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 9:e86306. 2014
    ..The E7 peptide up-modulated immune response (KPNA7, IGSF6, NCR3, TREM2, TUBAL3, IL8, NFKBIA), pro-apoptosis (BTG1, SEMA6A, IGFBP3 and SRGN), anti-apoptosis (NFKBIA), DNA repair (MRPS11, ..
  18. pmc LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Orphanet J Rare Dis 9:68. 2014
    ..sclerosing leukoencephalopathy and multifocal bone cysts, caused by a loss-of-function mutation of either DAP12 or TREM2. TREM2 and DAP12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic ..
  19. pmc Coding variants in TREM2 increase risk for Alzheimer's disease
    Sheng Chih Jin
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave B8134, St Louis, MO 63110, USA
    Hum Mol Genet 23:5838-46. 2014
    The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory response...
  20. pmc Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update
    Surjyadipta Bhattacharjee
    Departments of Neurology, Neuroscience and Ophthalmology, Louisiana State University Neuroscience Center and Health Sciences Center New Orleans, LA, USA
    Front Aging Neurosci 6:116. 2014
  21. pmc Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, People s Republic of China
    Neuropsychopharmacology 39:2949-62. 2014
    b>Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of ..
  22. doi Genetics of Alzheimer's disease
    Vincent Chouraki
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA Framingham Heart Study, Framingham, MA, USA
    Adv Genet 87:245-94. 2014
    ..This effort has identified two novel genes, TREM2 and PLD3, and shown a role for APP in LOAD...
  23. pmc The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
    Marco Genua
    IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy
    J Transl Med 12:293. 2014
    ..This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches. ..
  24. pmc Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells
    Heather M Wilkins
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA University of Kansas Alzheimer s Disease Center, University of Kansas Medical Center, Kansas City, KS, USA
    J Alzheimers Dis 45:305-18. 2015
    ..BV2 microglial cells treated with mitochondrial lysates showed decreased TREM2 mRNA, increased TNFα mRNA, increased MMP-8 mRNA, increased IL-8 mRNA, redistribution of NFκB to the nucleus, and ..
  25. pmc TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Cell 160:1061-71. 2015
    b>Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation...
  26. pmc TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis
    Maria Bucova
    Institute of Immunology, Faculty of Medicine, Comenius University, 81372 Bratislava, Slovakia
    Mediators Inflamm 2015:181986. 2015
    ..A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels. ..
  27. doi Perturbation of the transcriptome: implications of the innate immune system in Alzheimer's disease
    Fuhai Song
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China
    Curr Opin Pharmacol 26:47-53. 2016
    ..of transcriptome studies and other types of studies has further elucidated the roles of specific immune pathways in distinct cell types during AD development and highlighted the critical contributions from immune genes such as TREM2.
  28. ncbi Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone
    Annika Ohrfelt
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Mult Scler 22:1587-1595. 2016
    ..Loss-of-function mutations in TREM2 or in the gene encoding its adaptor protein cause the rare Nasu-Hakola disease (NHD)...
  29. pmc sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
    Marc Suárez-Calvet
    Biomedical Center BMC, Biochemistry, Ludwig Maximilians University Munich, Munich, Germany German Center for Neurodegenerative Diseases DZNE Munich, Munich, Germany
    EMBO Mol Med 8:466-76. 2016
    b>TREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD)...
  30. doi Targeting microglia for the treatment of Alzheimer's Disease
    Paul D Wes
    Neuroinflammation Department, Lundbeck Research USA, Paramus, New Jersey
    Glia 64:1710-32. 2016
    ..Coding and noncoding polymorphisms in several genes expressed in microglia-including APOE, TREM2, CD33, GRN, and IL1RAP-alter AD risk, and therefore could be considered as entry points for therapeutic ..
  31. doi [Molecular Pathogenesis of Nasu-Hakola Disease Brain Lesions]
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University
    Brain Nerve 68:543-50. 2016
    ..owing to multifocal bone cysts and leukoencephalopathy, caused by various genetic mutations of either DAP12 or TREM2. Loss-of-function of TREM2-DAP12, constituting a signaling complex on osteoclasts and microglia, plays a central ..
  32. pmc TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
    Peng Yuan
    Department of Neurology, Yale University, New Haven, CT 06511, USA Department of Neuroscience, Yale University, New Haven, CT 06511, USA
    Neuron 90:724-39. 2016
    Haplodeficiency of the microglia gene TREM2 increases risk for late-onset Alzheimer's disease (AD) but the mechanisms remain uncertain...
  33. pmc Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis
    Tassili A F Weehuizen
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    PLoS Negl Trop Dis 10:e0004747. 2016
    ..TREM-1 has been suggested as a biomarker for sepsis and melioidosis. We aimed to characterize the expression and function of TREM-1 and TREM-2 in melioidosis...
  34. doi TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
    Felix L Yeh
    Department of Neuroscience, Genentech Inc, South San Francisco, CA 94080, USA
    Neuron 91:328-40. 2016
    Genetic variants of TREM2, a protein expressed selectively by microglia in the brain, are associated with Alzheimer's disease (AD)...
  35. doi Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva
    S S Chen
    State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China
    J Periodontal Res . 2016
    ..This study is the first to identify TREM-2 in periodontal tissue, as well as the protein expression changes of TREM-1 and TREM-2 in periodontal tissues...
  36. doi Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases
    Jie Han
    a Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, China
    Int J Neurosci 127:368-375. 2017
    ..One TREM, in particular, TREM2, is highly expressed on cells of the myeloid lineage...
  37. pmc Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains
    Li Ma
    Department of Neuroscience, Mayo Clinic, Jacksonville, 32224, FL, USA
    Mol Neurodegener 11:72. 2016
    Genetic analyses showed that the triggering receptor expressed in myeloid cells 2 (TREM2) p.R47H variant increases the risk for Alzheimer's disease (AD). The question of whether the p...
  38. pmc Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury
    Marc Suárez-Calvet
    German Center for Neurodegenerative Diseases DZNE Munich, Munich, Germany
    Sci Transl Med 8:369ra178. 2016
    ..However, no marker related to microglia has been included in the temporal evolution models of AD. TREM2 is a transmembrane protein involved in innate immunity and is selectively expressed by microglia and genetically ..
  39. pmc Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
    Matthias Brendel
    Department of Nuclear Medicine, Ludwig Maximilians Universit t M nchen Munich, Germany
    Front Aging Neurosci 9:8. 2017
    Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been reported to significantly increase the risk of developing Alzheimer's disease (AD)...
  40. pmc TREM2 and the neuroimmunology of Alzheimer's disease
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Harvard Medical School, Boston, MA 02115, USA
    Biochem Pharmacol 88:495-8. 2014
    ..two groups of investigators independently identified variants of the TREM2 gene, encoding triggering receptor expressed on myeloid cells 2 as causing increased susceptibility to late onset AD with an odds ratio similar to that of ..
  41. doi Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
    Teng Jiang
    Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, People s Republic of China
    Neurobiol Aging 35:1243-51. 2014
    ..b>Triggering receptor expressed on myeloid cells 2 (TREM2) is a newly identified risk gene for AD, which regulates inflammatory process in ..
  42. doi Long-term impact of neonatal inflammation on demyelination and remyelination in the central nervous system
    Karelle Benardais
    Department of Neurology, Hannover Medical School, Hannover, Germany Center for Systems Neuroscience, Hannover, Germany
    Glia 62:1659-70. 2014
    ..challenge impacts the phenotype of microglia since an elevated mRNA expression of microglia related genes such as TREM 2, CD11b, TNF-α, TGF-β1, HGF, FGF-2, and IGF-1 was found in these preconditioned mice during early demyelination...
  43. pmc Gene-based rare allele analysis identified a risk gene of Alzheimer's disease
    Jong Hun Kim
    Department of Neurology, Dementia Center, Stroke Center, Ilsan Hospital, National Health Insurance Service, Goyang shi, South Korea
    PLoS ONE 9:e107983. 2014
    ..The association of ZNF628 with AD was not dependent on APOE ε4. APOE and TREM2 were also significantly associated with AD, although not at genome-wide significance levels...
  44. doi Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis
    Riem Gawish
    Ce M M, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria and National Food Institute, Division for Epidemiology and Microbial Genomics, Technical University of Denmark, Lyngby, Denmark
    FASEB J 29:1247-57. 2015
    ..Our results illustrate TREM-2's effects on infection-triggered inflammation and identify TREM-2 as a potential target to prevent overwhelming inflammation while preserving antibacterial-effector functions...
  45. doi A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology
    Mar Matarin
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK Reta Lila Research Laboratories and Department of Molecular Neuroscience, UCL, Institute of Neurology, 1 Wakefield Street, London WC1N 1PJ, UK
    Cell Rep 10:633-44. 2015
    ..The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice...
  46. doi Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis
    Man Huang
    Department of General Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Am J Alzheimers Dis Other Demen 30:541-6. 2015
    ..The goal of this systematic study and meta-analysis was to assess the association between Triggering receptor expressed on myeloid cells 2 (TREM2) variants and AD in East Asian population.
  47. pmc TREM2 is associated with increased risk for Alzheimer's disease in African Americans
    Sheng Chih Jin
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue B8134, St Louis, MO, 63110, USA
    Mol Neurodegener 10:19. 2015
    TREM2 encodes for triggering receptor expressed on myeloid cells 2 and has rare, coding variants that associate with risk for late-onset Alzheimer's disease (LOAD) in Caucasians of European and North-American origin...
  48. pmc TREM2 sustains microglial expansion during aging and response to demyelination
    Pietro Luigi Poliani
    J Clin Invest 125:2161-70. 2015
    ..Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as dextran sulphate and bacterial LPS, and activates ..
  49. pmc TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
    Kangyun Wu
    Pulmonary and Critical Care Medicine, Department of Medicine, Department of Pediatrics, Department of Pathology and Immunology, Department of Biochemistry and Biophysics, and Department of Cell Biology, Washington University School of Medicine, St Louis, MO 63110
    J Exp Med 212:681-97. 2015
    ....
  50. pmc The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
    Christina M Lill
    Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lubeck, Lubeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Electronic address
    Alzheimers Dement 11:1407-16. 2015
    A rare variant in TREM2 (p.R47H, rs75932628) was recently reported to increase the risk of Alzheimer's disease (AD) and, subsequently, other neurodegenerative diseases, i.e...
  51. doi Association Study of the TREM2 Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease
    Zohreh Mehrjoo
    Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Med Princ Pract 24:351-4. 2015
    To analyze the association between TREM2 exon 2 variants and late-onset (sporadic) Alzheimer's disease (AD) in an elderly Iranian population.
  52. pmc Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease
    Amanda Heslegrave
    Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Mol Neurodegener 11:3. 2016
    The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for Alzheimer's disease (AD), with only the apolipoprotein E (APOE) ε4 gene allele ..
  53. pmc microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration
    Surjyadipta Bhattacharjee
    LSU Neuroscience Center, Louisiana State University Health Science Center, New Orleans, LA, 70112, United States of America
    PLoS ONE 11:e0150211. 2016
    ..The triggering receptor expressed in myeloid/microglial cells-2 (TREM2), a trans-membrane-spanning, sensor-receptor of the immune-globulin/lectin-like gene superfamily is a critical ..
  54. pmc Assessment of the genetic variance of late-onset Alzheimer's disease
    Perry G Ridge
    Department of Biology, Brigham Young University, Provo, UT, USA
    Neurobiol Aging 41:200.e13-20. 2016
    ..Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD...
  55. doi A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese
    Teng Jiang
    Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA
    Neurobiol Aging 42:217.e1-3. 2016
    Two recent studies have identified that a rare coding variant (p.R47H) in exon 2 of triggering receptor expressed on myeloid cells 2 (TREM2) gene is associated with Alzheimer's disease (AD) susceptibility in Caucasians...
  56. pmc Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation
    Honghua Zheng
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, PR China
    Neurobiol Aging 42:132-41. 2016
    Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for ..
  57. doi Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond
    Elise Cuyvers
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Lancet Neurol 15:857-68. 2016
    ..type 2 diabetes, which is mostly a result of the strong effect of APOE ɛ4 and to a lesser extent the rare variant TREM2 p.Arg47His...
  58. pmc TREM2 p.R47H substitution is not associated with dementia with Lewy bodies
    Ronald L Walton
    Department of Neuroscience R L W, A I S O, M E M, O L B, K O, S R, R R, N E T, D W D, O A R, C L, Division of Biomedical Statistics and Informatics M G H, Department of Neurology N E T, R J U, J A v G, Z K W, N R G R, Department of Psychiatry and Psychology T J F, O A R, Mayo Clinic, Jacksonville, FL Department of Biology A I S O, O A R, University of North Florida, Jacksonville Department of Psychiatry and Psychology G E S, Department of Radiology K K, V J L, D T J, Department of Laboratory Medicine and Pathology J E P, B F B, Department of Neurology J E P, D T J, Russian Academy of Sciences
    Neurol Genet 2:e85. 2016
    ..3) These findings would suggest that DLB may be a distinct disease with shared genetic risk factors with PD and AD. ..
  59. doi Lymphoblast-derived integration-free iPS cell line from a female 67-year-old Alzheimer's disease patient with TREM2 (R47H) missense mutation
    Friederike Schröter
    Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Stem Cell Res 17:553-555. 2016
    ..lymphoblast cells from a female patient diagnosed with Alzheimer's disease (AD) possessing the missense mutation TREM2 p...
  60. ncbi Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease
    Kunihiko Kanatsu
    Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    Front Biosci (Landmark Ed) 22:180-192. 2017
    ..whole genome sequencing and exome sequencing have identified rare variants associated with LOAD, including TREM2...
  61. pmc Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia
    Christoph D Schmid
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA Digital Gene Technologies Inc, La Jolla, California 92037, USA
    J Neurochem 83:1309-20. 2002
    ....
  62. pmc Microglia and the control of autoreactive T cell responses
    Benoit Melchior
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, United States
    Neurochem Int 49:145-53. 2006
    ....
  63. doi Nasu-Hakola disease: The first case reported by Nasu and review: The 50th Anniversary of Japanese Society of Neuropathology
    Minoru Kaneko
    Center for Health, Safety and Environmental Management, Shinshu University, Departments ofNeuropsychiatry andPathology, Shinshu University School of Medicine, andDepartment of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Nagano, Japan
    Neuropathology 30:463-70. 2010
    ..It has recently been demonstrated that NHD is caused by a mutation in the TREM2 or DAP12 gene. The present paper demonstrates the first patient reported by Nasu and reviews NHD...
  64. doi Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
    Jun ichi Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Cell Mol Neurobiol 32:337-43. 2012
    ..presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP12 or TREM2. TREM2 and DAP12 constitute a receptor/adaptor complex expressed on osteoclasts, dendritic cells, macrophages, ..
  65. doi TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
    Gernot Kleinberger
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University Munich, 80336 Munich, Germany Munich Cluster for Systems Neurology SyNergy, 80336 Munich, Germany
    Sci Transl Med 6:243ra86. 2014
    Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and FTD-..
  66. pmc DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response
    Li Zhong
    From the Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China
    J Biol Chem 290:15866-77. 2015
    b>Triggering receptor expressed on myeloid cells 2 (TREM2) is a DAP12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells...
  67. doi Assessment of TREM2 rs75932628 association with Parkinson's disease and multiple system atrophy in a Chinese population
    Yongping Chen
    Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China
    Neurol Sci 36:1903-6. 2015
    Although rs75932628 in triggering receptor expressed on myeloid cells 2 (TREM2) was shown to increase the risk for Alzheimer's disease, there is no agreement on the association between this variant and the risk for Parkinson's disease (PD)..
  68. doi Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility
    Guiyou Liu
    Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China
    Mol Neurobiol 53:4931-8. 2016
    A rare TREM2 missense mutation (rs75932628-T) was reported to confer a significant Alzheimer's disease (AD) risk. A recent study indicated no evidence of the involvement of this variant in Parkinson's disease (PD)...
  69. pmc Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease
    Leah C Graham
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME, USA
    Sci Rep 6:21568. 2016
    ..Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed ..
  70. doi Parkinsonism, movement disorders and genetics in frontotemporal dementia
    José Fidel Baizabal-Carvallo
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge, Suite 9A, MS BCM 609 Houston, Texas 77030 4202, USA
    Nat Rev Neurol 12:175-85. 2016
    ..Less common gene mutations, such as those in TARDBP, CHMP2B, VCP, FUS and TREM2, can also present as atypical parkinsonism...
  71. pmc TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
    Yaming Wang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285
    J Exp Med 213:667-75. 2016
    b>Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer's disease ..
  72. pmc TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer
    Yinan Yao
    Department of Respiratory Diseases, First Affiliated Hospital of Zhejiang University, Hangzhou, China
    Oncotarget 7:29620-34. 2016
    ..In conclusion, these results indicate that TREM-2 might act as a negative immuno-regulatory molecule through Syk pathway in an IL-10 dependent manner and partially predicts prognosis in lung cancer patients. ..
  73. pmc Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis
    Vikrant Rai
    Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska 68178, United States of America
    PLoS ONE 11:e0154802. 2016
    ..These findings suggest a potential role of pDCs and TREM-1 in atherosclerotic plaque vulnerability. Thus, newer therapies could be developed to selectively block TREM-1 for stabilizing atherosclerotic plaques. ..
  74. pmc Genes associated with Alzheimer's disease: an overview and current status
    Mohan Giri
    Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People s Republic of China
    Clin Interv Aging 11:665-81. 2016
    ..identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10...
  75. doi Lymphoblast-derived integration-free iPS cell line from a 65-year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant
    Friederike Schröter
    Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr, 5, 40225 Dusseldorf, Germany
    Stem Cell Res 16:113-5. 2016
    Human lymphoblast cells from a male patient diagnosed with Alzheimer's disease (AD) expressing the TREM2 p...
  76. pmc TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
    Xianyuan Xiang
    Biomedical Center BMC, Biochemistry, Ludwig Maximilians University Munich, Munich, Germany Graduate School of Systemic Neuroscience, Ludwig Maximilians University Munich, Munich, Germany
    EMBO Mol Med 8:992-1004. 2016
    ..Recently, heterozygous mutations in the triggering receptor expressed on myeloid cells 2 (TREM2), a microglial gene involved in phagocytosis, were genetically linked to late onset AD ..
  77. doi Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation
    Filip Petković
    Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Universitat Autonoma de Barcelona, Bellaterra, 08193, Spain
    Glia 64:2104-2119. 2016
    ..Indeed, a microglial receptor involved in myelin phagocytosis, TREM2, as well as the phagolysosomal protein CD68 were lower in cuprizone-treated GFAP-IL6Tg compared with WT mice...
  78. doi Microglia and brain macrophages: An update
    Atsushi Sasaki
    Department of Pathology, Saitama Medical University, Saitama, Japan
    Neuropathology . 2016
    ..The molecules responsible are DAP12 or TREM2 in NHD and CSF1R in HDLS, respectively, but further studies are needed to clarify how exactly these microglial ..
  79. doi Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins
    Vongsavanh Phongsisay
    Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan Electronic address
    Immunobiology . 2016
    ..Functionally, PTX-binding receptors could be classified into two groups: inhibition (DAP12-coupled TREM2, ITIM-bearing SIRPα, SIGNR1/SIGNR3/DCSIGN) and activation (MyD88-associated TLR4, DAP12-coupled LMIR5/CD300b, FcR..
  80. doi Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases
    Christopher J Pelham
    Department of Biomedical Sciences and Center for Clinical and Translational Science, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Expert Rev Clin Immunol 10:243-56. 2014
    ..Recent progress into the roles of TREM/DAP12 signaling is critically reviewed here with a focus on metabolic, cardiovascular and inflammatory diseases. The expanding repertoire of putative ligands for TREM receptors is also discussed. ..
  81. doi Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ
    S Strobel
    Department of Neuropathology, Institute of Pathology, University of Wuerzburg, Josef Schneider Str 2, 97080, Wuerzburg, Germany
    J Neural Transm (Vienna) 122:1069-76. 2015
    ..the role of chemokines such as CX3CL1, on the triggering receptors expressed by myeloid cells (TREMs), especially TREM2, and on the transcription factor/nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARγ)..
  82. pmc TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
    Taylor R Jay
    The Lerner Research Institute and Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195 Case Western Reserve University, Cleveland, OH 44106
    J Exp Med 212:287-95. 2015
    Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases...
  83. doi Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update
    Zhi Gang Zhang
    School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
    Arch Immunol Ther Exp (Warsz) 63:333-44. 2015
    ..In the present study, we try to review the inflammation in AD and immunity-associated GWAS risk genes like HLA-DRB5/DRB1, INPP5D, MEF2C, CR1, CLU and TREM2.
  84. pmc The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
    Charles C Bailey
    From the Department of Immunobiology and Microbial Sciences, The Scripps Research Institute, Jupiter, Florida 33458
    J Biol Chem 290:26033-42. 2015
    The triggering receptor expressed on myeloid cells 2 (TREM2) is an Ig-like V-type receptor expressed by populations of myeloid cells in the central nervous system and periphery...
  85. pmc CD33 modulates TREM2: convergence of Alzheimer loci
    Gail Chan
    Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 18:1556-8. 2015
    ..The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression...
  86. doi TREM-1, a negative regulator of human osteoclastogenesis
    Bitnara Lee
    Departments of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
    Immunol Lett 171:50-9. 2016
    ..In conclusion, we demonstrate that TREM-1 acts as a negative regulator of human osteoclast differentiation and identify a novel mechanism of negative regulation of osteoclastogenesis that plays a role in inflammation. ..
  87. doi Targeting innate immunity for neurodegenerative disorders of the central nervous system
    Katrin I Andreasson
    Department of Neurology and Neurological Sciences, Stanford Neuroscience Institute, Stanford University School of Medicine, Stanford, CA, USA
    J Neurochem 138:653-93. 2016
    ..Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article...
  88. ncbi Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease
    Taylor R Jay
    Department of Neurosciences, Case Western Reserve University, 44106
    J Neurosci . 2016
    ..of immune-related genetic risk factors for AD, including coding variants in the gene triggering receptor expressed on myeloid cells 2 (TREM2)...
  89. pmc Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
    Hideyuki Takahashi
    Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT, 06536, USA
    Acta Neuropathol . 2017
    ..caused by PGRN deficiency-induced expression of TYROBP network genes (TNG) including an AD risk factor Trem2. PGRN-deficient APP/PS1 mice also exhibit less severe axonal dystrophy and partially improved behavior phenotypes...
  90. ncbi The enigmatic function of TREM-2 in osteoclastogenesis
    Marco Colonna
    Washington University School of Medicine, St Louis, Department of Pathology and Immunology, MO, USA
    Adv Exp Med Biol 602:97-105. 2007
    The triggering receptor expressed on myeloid cells 2 (TREM-2) is a member of family of receptors that play a central role in regulating function of myeloid cells...
  91. pmc The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells
    Gillian C Whittaker
    Cancer and Inflammation Program, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 285:2976-85. 2010
    ..Together these data identify LAB as a critical, LAT-independent regulator of TREM-2 signaling and macrophage development capable of controlling subsequent inflammatory responses...
  92. doi TREM-2 promotes macrophage-mediated eradication of Pseudomonas aeruginosa via a PI3K/Akt pathway
    M Zhu
    Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China Key Laboratory of Tropical Diseases Control, Ministry of Education, Sun Yat Sen University, Guangzhou, China
    Scand J Immunol 79:187-96. 2014
    b>Triggering receptor expressed on myeloid cells 2 (TREM-2) is a cell surface receptor abundantly expressed on myeloid lineage cells such as macrophages and dendritic cells...
  93. doi C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation
    Eino Solje
    Institute of Clinical Medicine Neurology, University of Eastern Finland, Kuopio, Finland
    Neurobiol Aging 35:1780.e13-7. 2014
    ..Mutations in DNAX-activation protein 12 (DAP12) and triggering receptor expressed on myeloid cells 2 (TREM2) are the known genetic causes of NHD...
  94. pmc The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia
    Omar Sharif
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria
    PLoS Pathog 10:e1004167. 2014
    ..This work is the first to disclose a role for TREM-2 in clinically relevant respiratory tract infections and demonstrates a previously unknown link between TREM-2 and opsonin production within the lungs...
  95. pmc Genetic determinants of disease progression in Alzheimer's disease
    Xingbin Wang
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA
    J Alzheimers Dis 43:649-55. 2015
    ..05) either within or adjacent to seven known LOAD genes (INPP5D, MEF2C, TREM2, EPHA1, PTK2B, FERMT2, and CASS4) that harbor both risk and protective SNPs...
  96. pmc Triggering receptor expressed on myeloid cells receptor family modulators: a patent review
    Christopher J Pelham
    Creighton University School of Medicine, Department of Biomedical Sciences and Center for Clinical and Translational Science, Omaha, NE 68178, USA
    Expert Opin Ther Pat 24:1383-95. 2014
    ..TREM-1 (CD354) and TREM-2 share the transmembrane adaptor DNAX-activation protein of 12 kDa (DAP12), but they possess separate stimulatory and inhibitory functional roles, especially in myeloid cells...
  97. doi Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus
    Ji Seon Park
    Alzheimer s Disease Experts Lab ADEL, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Department of Brain Science, University of Ulsan College of Medicine, Seoul, Republic of Korea Bio Medical Institute of Technology BMIT, University of Ulsan College of Medicine, Seoul, Republic of Korea Cell Dysfunction Research Center CDRC, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Traffic 16:510-8. 2015
    The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune-modulatory receptor involved in phagocytosis and inflammation...
  98. pmc TREM2 regulates microglial cell activation in response to demyelination in vivo
    Claudia Cantoni
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8111, St Louis, MO, 63110, USA
    Acta Neuropathol 129:429-47. 2015
    ..b>Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in humans cause ..
  99. doi Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response
    Carmen Correale
    Division of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Gastroenterology 144:346-356.e3. 2013
    ..We investigated the expression of TREM-2 in the intestinal lamina propria and its role in the development of colonic inflammation...
  100. doi TREM2: a new risk factor for Alzheimer's disease
    Rr Singaraja
    Translational Laboratory in Genetic Medicine TLGM, Agency for Science, Technology and Research A STAR Department of Medicine, National University of Singapore, 30 Medical Drive, Singapore 117609, Singapore
    Clin Genet 83:525-6. 2013
    b>TREM2 variants in Alzheimer's disease Guerreiro et al. (2013) The New England Journal of Medicine 368:117-127 Variant of TREM2 associated with the risk of Alzheimer's disease. Jonsson et al...
  101. pmc TREM2 is associated with the risk of Alzheimer's disease in Spanish population
    Bruno A Benítez
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Aging 34:1711.e15-7. 2013
    Two recent studies have reported the association of rs75932628-T in the TREM2 gene with the risk for Alzheimer's disease (AD). Rs75932628-T is a rare nonsynonymous variant (p...

Research Grants23

  1. TREM2 regulation of macrophages in spinal cord injury and CNS endogenous repair
    Phillip G Popovich; Fiscal Year: 2013
    ..lentiviral) techniques to manipulate expression of the triggering receptor expressed on myeloid cells-2 (TREM2) on resident microglia and myeloid precursor cells, i.e...
  2. Midori A Yenari; Fiscal Year: 2014
    ..Triggering receptor expressed by myeloid cells-2 (TREM2) is a recently discovered receptor involved in the innate immune system...
  3. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
    ..We will determine whether SHIP1 regulates DAP12 signaling in vivo after direct activation of DAP12 with anti-TREM2 antibodies or blockade of DAP12 with TREM2-fusion protein...
  4. Mary C Nakamura; Fiscal Year: 2016
    ..3) Determine the effect of aging on macrophage and mesenchymal stem cell (MSC) interactions and determine the requirement for the myeloid cell receptor TREM2 in macrophage: MSC interactions
  5. Nucleosides and TREM2 Mediate Inflammation-Induced Bone Loss
    George Pan; Fiscal Year: 2010
    ..a totally different angle: inflammation-induced extracellular nucleosides as ligands for the triggering receptor expressed on myeloid cells 2 (TREM2), which is thus a unique receptor linking inflammation, immune function and bone ..
  6. Unraveling the Mystery of Molecular Phagocyte Biology for Microglia
    Wei Li; Fiscal Year: 2013
    ..For example, mutations of phagocytic receptor TREM2 with unknown ligands impair microglial phagocytosis and upregulate pro-inflammatory cytokines, leading to a ..
  7. Steven G Younkin; Fiscal Year: 2016
    ..in the complement cascade, CR1 and CLU, show significant genetic associations with AD, and rare coding variants in TREM2 also confer substantial risk for AD...
  8. Carlos Cruchaga; Fiscal Year: 2016
    ..In a recent study published in the New England Journal of Medicine, we identified a novel rare variant in TREM2 with large effect size on risk for AD by using exome-sequencing and follow-up sequencing/genotyping in a large ..
  9. Role of DAP12 in type 1 anti-mycobacterial immunity
    Zhou Xing; Fiscal Year: 2005
    ..We strongly believe that our studies will provide new insights into the mechanisms of type 1 anti-microbial immunity and novel targets for immune modulation. ..
  10. Triggering Receptors and CNS Inflammation
    MONICA CARSON; Fiscal Year: 2006
    ..Our analysis will focus on signals and outcomes relevant for bacterial signals, CNS autoimmunity, and Alzheimer's disease. [unreadable] [unreadable]..
  11. The Role of Triggering Receptor Expressed on Myeloid Cells-2 (Trem2) on Microglia
    Christine Hsieh; Fiscal Year: 2008
    ..Triggering receptor expressed on myeloid cells-2 (TREM2) and DAP12 are a receptor complex expressed on the cell surface of microglia, and has been previously ..
  12. Microglial Signaling Mechanisms in Alzheimer's Disease
    Gary E Landreth; Fiscal Year: 2010
    ..We propose to definitively test whether oxidative damage observed in an animal model of AD is due to NADPH oxidase action by examination of animals in which the oxidase has been genetically inactivated. ..
  13. Plasmacytoid Dendritic Cells in Anti-Tumor Response
    Marco Colonna; Fiscal Year: 2008
    ..These findings also substantiate the physiological relevance of the proposed studies to clinical human cancer situations. ..
  14. The Functional of TREM-1 in Sepsis
    Marco Colonna; Fiscal Year: 2010
    ..We also have detected a binding partner of TREM-1 (the TREM-1 ligand) and we propose to identify this molecule as it may serve as a novel target for the treatment of septic patients, ..
  15. Inflammation, Abeta, and pericyte pathogenic roles
    Lih Fen Lue; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  16. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Immune Defense: The Role of NKG2D/DAP10
    Marco Colonna; Fiscal Year: 2007
    ..abstract_text> ..
  18. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..abstract_text> ..
  19. APOE EFFECT ON CNS NEURONS--ROLE OF LRP
    David Holtzman; Fiscal Year: 2003
    ..These studies with physiological preparations of apoE as well as both in vivo and in vitro models should provide new insights into mechanisms underlying the link between apoE, LRP, ABeta, and Alzheimer's disease. ..
  20. Interferon Regulation in Systemic Lupus
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..
  21. CNS/plasma ABeta clearance of anti-ABeta antibody
    David Holtzman; Fiscal Year: 2003
    ..This will determine how anti-Abeta antibodies influence CNS/plasma Abeta transport exchanges. ..
  22. Nectins in Tumor Immunosurveillance
    Marco Colonna; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2006
    ..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..