TRAX

Summary

Gene Symbol: TRAX
Description: translin associated factor X
Alias: TRAX, translin-associated protein X, translin-like protein
Species: human

Top Publications

  1. ncbi Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    FEBS Lett 401:109-12. 1997
  2. pmc Structure of C3PO and mechanism of human RISC activation
    Xuecheng Ye
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 18:650-7. 2011
  3. ncbi DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)
    Tuba Erdemir
    Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey
    J Cell Sci 115:207-16. 2002
  4. ncbi Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA
    V M Chennathukuzhi
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 276:13256-63. 2001
  5. ncbi Co-expressed recombinant human Translin-Trax complex binds DNA
    Gagan D Gupta
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    FEBS Lett 579:3141-6. 2005
  6. ncbi Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation
    Shicheng Yang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    J Biol Chem 279:12605-14. 2004
  7. doi A druggable target for rescuing microRNA defects
    Ken Asada
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Bioorg Med Chem Lett 26:4942-4946. 2016
  8. pmc Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X
    Finly Philip
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    FASEB J 26:4903-13. 2012
  9. doi A genome-wide approach to screen for genetic variants in broilers (Gallus gallus) with divergent feed conversion ratio
    Tejas M Shah
    Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, 388 001, Gujarat, India
    Mol Genet Genomics 291:1715-25. 2016
  10. pmc Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
    XiuPing Fu
    Solomon H Snyder Department of Neuroscience and Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, United States
    Neurobiol Learn Mem 133:225-32. 2016

Research Grants

  1. SUZANNE F SCARLATA; Fiscal Year: 2014
  2. Biochemical Studies of Drosophila RNA-induced Silencing Complex
    Qinghua Liu; Fiscal Year: 2010
  3. Solomon H Snyder; Fiscal Year: 2016
  4. GENE EXPRESSION DURING SPERMATOGENESIS
    NORMAN HECHT; Fiscal Year: 2006
  5. Structural analysis of TB-RBP, a DNA/RNA-binding protein
    Jon Robertus; Fiscal Year: 2005
  6. REGULATION OF REPRODUCTION
    Synthia Mellon; Fiscal Year: 2005
  7. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
  8. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010

Scientific Experts

  • Vinay Kumar
  • R S Devon
  • Barbara J Duff
  • Maria Victoria Francia
  • Daniel I Levy
  • M S Mathews
  • Alexandra Schosser
  • Taro Kishi
  • P A Thomson
  • Don B Clewell
  • S H Mellon
  • Ru Feng Wu
  • J Kirsty Millar
  • Giovanni Martinelli
  • T D Cannon
  • Martin S Taylor
  • Qinghua Liu
  • Jon Robertus
  • Finly Philip
  • Suzanne Scarlata
  • SUZANNE F SCARLATA
  • Solomon H Snyder
  • NORMAN HECHT
  • Jay M Baraban
  • Elad Eliahoo
  • Zhi Li
  • Norman B Hecht
  • Alessa Jaendling
  • Gagan D Gupta
  • Chung Nan Sun
  • Shriya Sahu
  • Shicheng Yang
  • Xuecheng Ye
  • Ying Liu
  • Ron Ben Yosef
  • Haim Manor
  • Yijuang Chern
  • Vargheese M Chennathukuzhi
  • Tejas M Shah
  • XiuPing Fu
  • Jeffrey D Bray
  • Ken Asada
  • Kairi Kärblane
  • Xuan Li
  • Tuba Erdemir
  • C Wälzlein
  • Matthew J Eckert
  • W Hennah
  • Bárbara Arias
  • Jing Yan Cheng
  • Zain Paroo
  • Eneida A Parizotto
  • V M Chennathukuzhi
  • Gagan Deep Gupta
  • Marcus Bleicher
  • Liande Li
  • Anjanappa Ram Murthy
  • Tieshan Xu
  • William Hennah
  • Omozuanvbo Aisiku
  • Yen Ching Wu
  • Yoon Shin Cho
  • Yuan Tian
  • Chunyang Liang
  • Akiko Okuda
  • Omozuanvbo R Aisiku
  • Matthew Lluis
  • Ramsay J McFarlane
  • Kenji Nakata
  • Jaime M Williams
  • H Kilpinen
  • Ana Herrero
  • Uwe Schröer
  • Outi M Palo
  • T Varilo
  • L Peltonen
  • T Paunio
  • Maike Claussen
  • Leena Peltonen
  • Christian B Gocke
  • Timo Partonen
  • Xuan Zhang
  • Hongtao Yu
  • Jouko Lonnqvist
  • Orly Laufman
  • Tiina Paunio
  • Eleanor S Segal
  • Patrick Ryan Potts
  • Miyuki Matsuda
  • Krishna M Singh

Detail Information

Publications85

  1. ncbi Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    FEBS Lett 401:109-12. 1997
    ..interacts with other proteins using a yeast two-hybrid system and identified an associated 33 kd protein partner, TRAX, with extensive amino acid homology...
  2. pmc Structure of C3PO and mechanism of human RISC activation
    Xuecheng Ye
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 18:650-7. 2011
    ..the crystal structure of hC3PO, which reveals an asymmetric octamer barrel consisting of six translin and two TRAX subunits...
  3. ncbi DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)
    Tuba Erdemir
    Bilkent University, Molecular Biology and Genetics Department, 06533, Bilkent, Ankara, Turkey
    J Cell Sci 115:207-16. 2002
    ..employed the yeast two-hybrid system and found that C1D interacts specifically with Translin-associated factor X, TRAX. Although the biological function of TRAX remains unknown, its bipartite nuclear targeting sequences suggest a role ..
  4. ncbi Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA
    V M Chennathukuzhi
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6142, USA
    J Biol Chem 276:13256-63. 2001
    b>Trax (Translin-associated factor X) has been shown to interact with TB-RBP/Translin by its coimmunoprecipitation and in yeast two-hybrid assays...
  5. ncbi Co-expressed recombinant human Translin-Trax complex binds DNA
    Gagan D Gupta
    Synchrotron Radiation Section, Bhabha Atomic Research Centre, Mumbai 400 085, India
    FEBS Lett 579:3141-6. 2005
    b>Trax, expressed alone aggregates into insoluble complexes, whereas upon co-expression with Translin becomes readily soluble and forms a stable heteromeric complex ( approximately 430 kDa) containing both proteins at nearly equimolar ratio...
  6. ncbi Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation
    Shicheng Yang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    J Biol Chem 279:12605-14. 2004
    ..Reintroduction of TB-RBP remedies this defect. A partner protein of TB-RBP, Translin-associated factor X (TRAX), was absent in TB-RBP-deficient MEFs, despite normal TRAX mRNA levels...
  7. doi A druggable target for rescuing microRNA defects
    Ken Asada
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Bioorg Med Chem Lett 26:4942-4946. 2016
    ..We previously identified the Translin/Trax (TN/TX) ribonuclease complex as a pre-miRNA degrading enzyme that competes with pre-miRNA processing by Dicer...
  8. pmc Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X
    Finly Philip
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    FASEB J 26:4903-13. 2012
    ..We have previously found that in solution PLCβ1 binds to the RNA processing protein translin-associated factor X (TRAX) with nanomolar affinity and that this binding competes with G proteins...
  9. doi A genome-wide approach to screen for genetic variants in broilers (Gallus gallus) with divergent feed conversion ratio
    Tejas M Shah
    Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, 388 001, Gujarat, India
    Mol Genet Genomics 291:1715-25. 2016
    ..These findings should facilitate the discovery of causative variants for FCR and contribute to marker-assisted selection. ..
  10. pmc Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
    XiuPing Fu
    Solomon H Snyder Department of Neuroscience and Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, United States
    Neurobiol Learn Mem 133:225-32. 2016
    ..we present an overview of several molecular pathways implicated in mediating microRNA degradation: Lin-28, translin/trax, and MCPIP1...
  11. doi Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX)
    Matthew J Eckert
    From the Department of Surgery, Madigan Army Medical Center, M J E, D W N, M J M, Tacoma Washington Trauma and Acute Care Surgery Service, Legacy Emanuel Medical Center, S I, M J M, Portland, Oregon and Department of Surgery, William Beaumont Army Medical Center, T M W, El Paso and US Army Institute of Surgical Research, S D T, San Antonio, Texas
    J Trauma Acute Care Surg 77:852-8; discussion 858. 2014
    ..It has also shown significantly reduced blood loss and transfusion requirements in major elective pediatric surgery, but no published data have examined the use of TXA in pediatric trauma...
  12. pmc Low-resolution structure of Drosophila translin
    Vinay Kumar
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India
    FEBS Open Bio 2:37-46. 2012
    ..The similar octameric quaternary fold in translin orthologs and in translin-TRAX complexes suggests an up-down dimer as the basic structural subunit of translin-like proteins...
  13. doi Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population
    Anjanappa Ram Murthy
    Department of Psychiatry, Molecular Genetics Laboratory, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    J Hum Genet 57:523-30. 2012
    ..Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of SCZ and BPAD...
  14. pmc Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ
    Shriya Sahu
    From the Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York 11794 8661
    J Biol Chem 289:5134-44. 2014
    ..C3PO consists of two subunits of the endonuclease translin-associated factor X (TRAX) and six subunits of the nucleotide-binding protein translin...
  15. doi Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe
    Elad Eliahoo
    Department of Biology, Technion Israel Institute of Technology, Haifa, Israel
    Biochim Biophys Acta 1844:767-77. 2014
    Translin is a single-stranded DNA and RNA binding protein that has a high affinity for G-rich sequences. TRAX is a Translin paralog that associates with Translin. Both Translin and TRAX were highly conserved in eukaryotes...
  16. doi Simulations of dose enhancement for heavy atom nanoparticles irradiated by protons
    C Wälzlein
    GSI Helmholtzzentrum fur Schwerionenforschung GmbH, Planckstraße 1, D 64291 Darmstadt, Germany Frankfurt Institute for Advanced Studies FIAS, Ruth Moufang Str 1, D 60438 Frankfurt am Main, Germany Technische Universität Darmstadt, Darmstadt, Germany
    Phys Med Biol 59:1441-58. 2014
    ..consisting of different high Z atomic materials has been investigated using the track structure Monte Carlo code TRAX. In the simulations, Fe, Ag, Gd, Pt and Au nanoparticles (r = 22 and 2 nm) were irradiated with monoenergetic ..
  17. doi [Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population]
    Xuan Li
    Early Intervention Department of Guangzhou Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510370, P R China email
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31:357-61. 2014
    ..To assess the association of neural development-related genes LIS1and TSNAX with bipolar disorder in a Chinese Han population...
  18. pmc ABCE1 is a highly conserved RNA silencing suppressor
    Kairi Kärblane
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia Competence Centre for Cancer Research, Tallinn, Estonia
    PLoS ONE 10:e0116702. 2015
    ..In addition, one of the identified proteins is translin, which together with its binding partner TRAX supports RNA interference.
  19. doi DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy
    Bárbara Arias
    Unitat d Antropologia Dep de Biologia Animal Facultat de Biologia and Institut de Biomedicina, Universitat de Barcelona IBUB, Barcelona, Spain Centro de Investigaciones Biomédicas en Red de Salud Mental CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain
    J Affect Disord 168:91-7. 2014
    ....
  20. doi Globo-H ceramide shed from cancer cells triggers translin-associated factor X-dependent angiogenesis
    Jing Yan Cheng
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Cancer Res 74:6856-66. 2014
    ..Mechanistic investigations linked the angiogenic effects of GHCer to its endocytosis and binding to TRAX, with consequent release of PLCβ1 from TRAX to trigger Ca(2+) mobilization...
  21. pmc Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein
    Gagan Deep Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    PLoS ONE 7:e33035. 2012
    Translin and TRAX proteins play roles in very important cellular processes such as DNA recombination, spatial and temporal expression of mRNA, and in siRNA processing...
  22. pmc The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner
    Daniel I Levy
    Department of Medicine, Biological Sciences Division, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Physiol 588:2657-68. 2010
    ..Thus, regional heterogeneity in cardiac expression of MiRP3, Kv4.2 and KChIP2 in health and disease may establish the local attributes and magnitude of cardiac I(to)...
  23. doi Identification and characterization of genes related to the development of breast muscles in Pekin duck
    Tieshan Xu
    State Key Laboratory of Animal Nutrition Science, Institute of Animal Science, CAAS, No 2, Yuanmingyuan West Road, Haidian, 100193 Beijing, People s Republic of China
    Mol Biol Rep 39:7647-55. 2012
    ....
  24. pmc The translin-TRAX complex (C3PO) is a ribonuclease in tRNA processing
    Liande Li
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 19:824-30. 2012
    Conserved translin-TRAX complexes, also known as C3POs, have been implicated in many biological processes, but how they function remains unclear...
  25. pmc Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO
    Eneida A Parizotto
    Department of Biochemistry, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 20:380-6. 2013
    Oligomeric complexes of Trax and Translin proteins, known as C3POs, participate in several eukaryotic nucleic acid metabolism pathways, including RNA interference and tRNA processing...
  26. pmc Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies
    Marcus Bleicher
    Frankfurt Institute for Advanced Studies FIAS, Ruth Moufang Str 1, 60438 Frankfurt am Main, Germany Institut für Theoretische Physik, Johann Wolfgang Goethe Universitat, Max von Laue Str 1, 60438 Frankfurt am Main, Germany
    Beilstein J Nanotechnol 3:556-63. 2012
    ..Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.
  27. doi Molecular evolution of translin superfamily proteins within the genomes of eubacteria, archaea and eukaryotes
    Gagan D Gupta
    High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India
    J Mol Evol 75:155-67. 2012
    Translin and its interacting partner protein, TRAX, are members of the translin superfamily...
  28. ncbi Translin associated protein X is essential for cellular proliferation
    Shicheng Yang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6142, USA
    FEBS Lett 576:221-5. 2004
    ..reduce expression of an exogenously expressed gene, GFP and the endogenous protein, Translin-associated factor X (TRAX), in stably transfected Hela cell lines. The reduction of TRAX in Hela cells causes reduced cell proliferation...
  29. doi Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review
    Barbara J Duff
    University of Edinburgh, Division of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom
    Schizophr Res 147:1-13. 2013
    ..DISC1 interactions with translin-associated factor X (TRAX) and neuregulin have been shown to influence several regional volumes...
  30. ncbi High affinity binding of the Translin/Trax complex to RNA does not require the presence of Y or H elements
    Zhi Li
    Department of Neuroscience and Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 120:123-9. 2004
    Translin and its partner protein, Trax, are components of an RNA binding complex that has been implicated in suppressing translation of several mRNAs by binding to Y and H cis elements contained in these transcripts...
  31. pmc Catalytic domain of plasmid pAD1 relaxase TraX defines a group of relaxases related to restriction endonucleases
    Maria Victoria Francia
    Servicio de Microbiologia, Hospital Universitario Marqués de Valdecilla e Instituto de Formación e Investigación Marqués de Valdecilla, Santander 39008, Spain
    Proc Natl Acad Sci U S A 110:13606-11. 2013
    ..The relaxase TraX and the primary origin of transfer oriT2 are located close to each other and have been shown to be essential for ..
  32. pmc Role of phospholipase C-β in RNA interference
    Finly Philip
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    Adv Biol Regul 53:319-30. 2013
    ..the factors that localize PLCβ to the cytosol and nucleus, we have recently identified the binding partner, TRAX. TRAX is a nuclease and part of the machinery involved in RNA interference...
  33. ncbi Trax is a component of the Translin-containing RNA binding complex
    Patricia M Finkenstadt
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    J Neurochem 83:202-10. 2002
    ..In previous studies, we found that Translin and its partner protein, Trax, are components of a gel-shift complex that is highly enriched in brain extracts...
  34. ncbi Transfer origins in the conjugative Enterococcus faecalis plasmids pAD1 and pAM373: identification of the pAD1 nic site, a specific relaxase and a possible TraG-like protein
    M Victoria Francia
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, 48109, USA
    Mol Microbiol 45:375-95. 2002
    ..Analyses showed that Orf57 (to be called TraX) is the relaxase, which was found to induce a specific nick in the large inverted repeat inside oriT; the protein ..
  35. ncbi Isolation and characterization of the mouse translin-associated protein X (Trax) gene
    R S Devon
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Mamm Genome 11:395-8. 2000
  36. pmc C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation
    Ying Liu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 325:750-3. 2009
    ..system to purify an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax. C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand ..
  37. doi Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population
    Akiko Okuda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Neuromolecular Med 12:78-85. 2010
    ..Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small...
  38. pmc DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
    Kenji Nakata
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1385, USA
    Proc Natl Acad Sci U S A 106:15873-8. 2009
    ..Our results implicate a molecular mechanism of genetic risk associated with DISC1 involving specific alterations in gene processing...
  39. pmc Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study
    Elad Eliahoo
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nucleic Acids Res 38:2975-89. 2010
    ..b>TRAX is a Translin paralog associated with Translin, which has coevolved with it...
  40. pmc Analysis of nucleic acid binding by a recombinant translin-trax complex
    Matthew Lluis
    Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Biochem Biophys Res Commun 396:709-13. 2010
    ..Translin has a partner protein, translin-associated factor x (trax), which is believed to regulate translin's subcellular locale and affinity for certain RNA and DNA sequences...
  41. doi The A2A adenosine receptor rescues neuritogenesis impaired by p53 blockage via KIF2A, a kinesin family member
    Chung Nan Sun
    Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Dev Neurobiol 70:604-21. 2010
    ..We previously reported that the C terminus of the A2AR binds to translin-associated protein X (TRAX) and modulates nerve growth factor (NGF)-evoked neurite outgrowth in PC12 cells...
  42. doi Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore
    Alessa Jaendling
    North West Cancer Research Fund Institute, College of Natural Sciences, Bangor University, Memorial Building, Deiniol Road, Bangor, Gwynedd, LL57 2UW, United Kingdom
    Biochem J 429:225-34. 2010
    Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth regulation, mRNA ..
  43. pmc Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X
    Omozuanvbo R Aisiku
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 5:e15001. 2010
    ..Here, we identified a novel binding partner, translin-associated factor X (TRAX). TRAX is a cytosolic protein that can transit into the nucleus...
  44. pmc Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms
    Yen Ching Wu
    Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 116:1112-21. 2011
    ..We have found that translin and its partner protein, trax, undergo dendritic translocation in response to treatment with pilocarpine, a pro-convulsant muscarinic agonist ..
  45. pmc Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization
    Omozuanvbo Aisiku
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    Arch Biochem Biophys 509:186-90. 2011
    ..with similar rates and also interact identically with another known binding partner, translin-associated factor X (TRAX), which associates with PLCβ1 in the cytosol and nucleus...
  46. pmc Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex
    Yuan Tian
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, New York, USA
    Nat Struct Mol Biol 18:658-64. 2011
    b>Trax-translin heteromers, also known as C3PO, have been proposed to activate the RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand...
  47. doi Lack of association between translin-associated factor X gene (TSNAX) and methamphetamine dependence in the Japanese population
    Taro Kishi
    Department of Psychiatry Research, The Zucker Hillside Hospital, NY 11004, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1618-22. 2011
    ..TSNAX is located immediately upstream of DISC1 and has been shown to undergo intergenic splicing with DISC1. Based on this evidence, we hypothesized that TSNAX might be a good candidate gene for methamphetamine dependence...
  48. ncbi Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments
    Outi M Palo
    Department of Molecular Medicine, National Public Health Insitute, Helsinki, Finland
    Hum Mol Genet 16:2517-28. 2007
    ..Finding of alternative associating haplotypes in the same set of BPD families gives evidence for allelic heterogeneity within DISC1, eventually leading to heterogeneity in the clinical outcome as well...
  49. ncbi Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination
    Tuba Erdemir
    Bikent University, Molecular Biology and Genetics Department, Ankara, Turkey
    Mol Microbiol 46:947-57. 2002
    ..Recently, it was demonstrated that C1D can also interact with TRAX and prevent the association of TRAX with Translin, a factor known to bind DNA break-point junctions, and that over ..
  50. ncbi Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates
    Christian B Gocke
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 280:5004-12. 2005
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms...
  51. ncbi KIF2Abeta: A kinesin family member enriched in mouse male germ cells, interacts with translin associated factor-X (TRAX)
    Jeffrey D Bray
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6142, USA
    Mol Reprod Dev 69:387-96. 2004
    Translin associated factor X (TRAX) is a binding partner of TB-RBP/Translin...
  52. ncbi Co-localization of Trax and Mea2 in Golgi complex of pachytene spermatocytes in the mouse
    Miyuki Matsuda
    Kanagawa Cancer Center Research Institute, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    J Histochem Cytochem 52:1245-8. 2004
    ..Because Trax was shown to interact with Mea2 in yeast two-hybrid, we investigated the localization of Trax in pachytene ..
  53. ncbi The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells
    Yoon Shin Cho
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:31514-23. 2004
    ..Translin-associated factor X (TRAX) was identified as a protein that interacts with TB-RBP and is dependent upon TB-RBP for stabilization...
  54. ncbi Identification of Translin/Trax complex as a glucose response element binding protein in liver
    Ru Feng Wu
    Department of Internal Medicine, University of Texas Southwestern and The Dallas Veterans Affairs Medical Center, Box 151, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Biochim Biophys Acta 1624:29-35. 2003
    ..to identify GRBP, we purified to homogeneity cytosolic GRBP from rat liver extract and identified it as a Translin/Trax heteromeric complex...
  55. ncbi Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects
    William Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Hum Mol Genet 12:3151-9. 2003
    ..In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia...
  56. pmc Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes
    Vargheese Chennathukuzhi
    Center for Research on Reproduction and Women s Health, School of Medicine, Department of Biology, University of Pennsylvania, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Mol Cell Biol 23:6419-34. 2003
    ..Behavioral abnormalities were also seen. Compared to littermates, the TB-RBP-null mice appeared docile and exhibited reduced Rota-Rod performance...
  57. ncbi Evolutionary constraints on the Disrupted in Schizophrenia locus
    Martin S Taylor
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Genomics 81:67-77. 2003
    ..The amino acid sequence of DISC1 is diverging rapidly, although a putative nuclear localization signal and discrete blocks of coiled coil are specifically conserved features...
  58. ncbi Enterococcal plasmid transfer: sex pheromones, transfer origins, relaxases, and the Staphylococcus aureus issue
    Don B Clewell
    Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109 1078, USA
    Plasmid 48:193-201. 2002
    ..pAD1 has two origins of transfer, oriT1 and oriT2 and encodes a relaxase (TraX), which has been shown to specifically nick in oriT2. pAM373 has a site, oriT, that is similar to oriT2 of pAD1...
  59. ncbi Emerging importance of Pneumocystis carinii among indian immunosuppressed patients
    M S Mathews
    Department of Microbiology, CMC Hospital, Vellore 632 004, India
    Indian J Chest Dis Allied Sci 42:323-4. 2000
    ..All these 15 patients had CD4 T cell counts of less than 500 T lymphocyte equivalent (TLE) /ml as measured by a Trax ELISA assay...
  60. ncbi Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X
    Jeffrey D Bray
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6142, USA
    Genomics 79:799-808. 2002
    Translin-associated factor X (TRAX) is the predominantly cytoplasmic binding partner of TB-RBP/translin in mouse testis...
  61. pmc Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype
    V M Chennathukuzhi
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104 6142, USA
    Nucleic Acids Res 29:4433-40. 2001
    ..TB-RBP, TB-RBP(GTP) will interact with itself, with wild-type TB-RBP and with Translin associated factor X (Trax)...
  62. ncbi Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X
    G Meng
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    J Hum Genet 45:305-8. 2000
    The TRAX gene encodes a Translin-associated 33-kDa protein partner, TRAX...
  63. ncbi Part of Xenopus translin is localized in the centrosomes during mitosis
    A Castro
    Centre de Recherches de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, Montpellier Cedex 5, 34293, France
    Biochem Biophys Res Commun 276:515-23. 2000
    ..expression, its localisation, and its biochemical association with the protein named Translin associated factor X (Trax) in Xenopus oocytes...
  64. ncbi Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Department of Medical Sciences, The University of Edinburgh, Scotland, United Kingdom
    Genomics 67:69-77. 2000
    ..Several DISC1 transcripts contain TRAX (HGMW-approved symbol TSNAX) sequence at the 5' end...
  65. ncbi Alu and translisin recognition site sequences flanking translocation sites in a novel type of chimeric bcr-abl transcript suggest a possible general mechanism for bcr-abl breakpoints
    G Martinelli
    Molecular Biology Unit, Institute of Hematology and Medical Oncology Seragnoli, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Haematologica 85:40-6. 2000
    ..We further characterized a novel type of chimeric BCR-ABL mRNA transcript detected in a patient with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML)...
  66. ncbi Identification of translin and trax as components of the GS1 strand-specific DNA binding complex enriched in brain
    E Taira
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 71:471-7. 1998
    ..Sequencing of peptides derived from these proteins led to their identification as Translin and Trax, interacting proteins identified in studies of DNA recombination in lymphocytes...
  67. pmc The Escherichia coli K-12 F plasmid gene traX is required for acetylation of F pilin
    D Moore
    Department of Medical Microbiology and Immunology, Texas A and M University, College Station 77843
    J Bacteriol 175:1375-83. 1993
    ..suffice for synthesis of JEL92-reactive pilin, but synthesis of JEL93-reactive pilin is additionally dependent on traX. We concluded that the traX product is required for acetylation of F pilin...
  68. pmc Functional characterization of Drosophila Translin and Trax
    Maike Claussen
    Institute of Cell Biology, University of Bern, 3012 Bern, Switzerland
    Genetics 174:1337-47. 2006
    ..The Translin-associated factor X (Trax) interacts with Translin, and Trax protein stability depends on the presence of Translin...
  69. doi Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies
    A Schosser
    MRC SGDP Centre, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Mol Psychiatry 15:844-9. 2010
    ....
  70. pmc The Translin/Trax RNA binding complex: clues to function in the nervous system
    Zhi Li
    Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, USA
    Biochim Biophys Acta 1779:479-85. 2008
    Translin and Trax are components of an evolutionarily conserved RNA binding complex...
  71. ncbi Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX
    Alessa Jaendling
    North West Cancer Research Fund Institute, University of Wales Bangor, Bangor, Gwynedd, LL57 2UW, United Kingdom
    Biochim Biophys Acta 1783:203-13. 2008
    ..It has a binding partner, translin-associated protein X (TRAX), levels of which are regulated by the translin protein in higher eukaryotes...
  72. ncbi Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration
    Uwe Schröer
    Department of Experimental Ophthalmology, School of Medicine, University Eye Hospital Munster, Domagkstrasse 15, 48149 Munster, Germany
    Eur J Neurosci 26:2169-78. 2007
    ..Using proteomics, we have identified translin-associated factor X (Trax), a DNA-binding factor that is expressed during this period of postnatal development...
  73. ncbi Sequence and conservation of genes at the distal end of the transfer region on plasmids F and R6-5
    D S Cram
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    Gene 104:85-90. 1991
    ..ORF248, which we have designated traX, and ORF186 (finO) are highly conserved on both plasmids...
  74. ncbi Salmonella enterica serotype Typhimurium carrying hybrid virulence-resistance plasmids (pUO-StVR): a new multidrug-resistant group endemic in Spain
    Ana Herrero
    Departamento de Biologia Funcional, Area de Microbiologia, Facultad de Medicina, University of Oviedo, C Julián Clavería No 6, E 33006 Oviedo, Spain
    Int J Med Microbiol 298:253-61. 2008
    ..2000bp; (iii) the spvC, rck, samA, oriT, traT, traX, repA (RepFIIA), and parA/B genes (but not rsk and pefABCD) of pSLT; (iv) a hybrid plasmid of ca...
  75. ncbi Association of DISC1 with autism and Asperger syndrome
    H Kilpinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Mol Psychiatry 13:187-96. 2008
    ..Here we have addressed the allelic diversity of the DISC1, DISC2 and TRAX genes, clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and ..
  76. ncbi Translin coactivates steroidogenic factor-1-stimulated transcription
    Synthia H Mellon
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0556, USA
    Mol Endocrinol 21:89-105. 2007
    ..Thus, we have identified a new factor that works together with SF-1 to augment gene transcription in a DNA-specific fashion...
  77. pmc A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder
    Jaime M Williams
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 149:1758-62. 2009
    ....
  78. ncbi Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X
    Chung Nan Sun
    Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan
    Mol Pharmacol 70:454-66. 2006
    ..the cytoplasmic tail of the A(2A)-R as bait, a novel-A(2A)-R-interacting protein [translin-associated protein X (TRAX)] was identified in a yeast two-hybrid screen...
  79. ncbi Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory
    Tyrone D Cannon
    Department of Psychology, 1285 Franz Hall, University of California Los Angeles, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 62:1205-13. 2005
    ..Chromosome 1q42 is among several genomic regions showing replicated evidence of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this relationship remain to be identified...
  80. ncbi Risk management strategies in the postmarketing period : safety experience with the US and European bosentan surveillance programmes
    Eleanor S Segal
    Department of Global Drug Safety, Drug Regulatory Affairs and Biometry, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
    Drug Saf 28:971-80. 2005
    ..In Europe, the Tracleer) Excellence (TRAX PMS) database is a novel European non-interventional, prospective, internet-based surveillance system initiated by ..
  81. ncbi A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia
    W Hennah
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Mol Psychiatry 10:1097-103. 2005
    ..of four significantly associated haplotypes that specifically implicate the Translin-Associated Factor X (TRAX) and Disrupted in Schizophrenia 1 and 2 (DISC1 and DISC2) genes in the genetic etiology of schizophrenia...
  82. pmc Human MMS21/NSE2 is a SUMO ligase required for DNA repair
    Patrick Ryan Potts
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, 75390 9041, USA
    Mol Cell Biol 25:7021-32. 2005
    ..hMMS21 stimulates sumoylation of hSMC6 and the DNA repair protein TRAX. Depletion of hMMS21 by RNA interference (RNAi) sensitizes HeLa cells toward DNA damage-induced apoptosis...
  83. pmc Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX
    Orly Laufman
    Department of Biology, Technion Israel Institute of Technology Haifa 32, 000, Israel
    Nucleic Acids Res 33:4128-39. 2005
    ..It also binds, with lesser affinities, other single-stranded G-rich DNA and RNA sequences. TRAX is a human protein that bears a homology to Translin and interacts with it...
  84. ncbi Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population
    Xuan Zhang
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 79:175-80. 2005
    ..In the pedigree, the TRAX gene, located adjacent to DISC1 on the disrupted chromosome 1, may also contribute to the pathophysiology of the ..
  85. ncbi Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population
    P A Thomson
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 10:657-68, 616. 2005
    The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with ..

Research Grants8

  1. SUZANNE F SCARLATA; Fiscal Year: 2014
    ..We have identified a novel protein partner of PLC? translin-associated protein X (TRAX)...
  2. Biochemical Studies of Drosophila RNA-induced Silencing Complex
    Qinghua Liu; Fiscal Year: 2010
    ..this core RISC reconstitution system was used to purify a novel RNAi activator that consists of Translin and Trax proteins...
  3. Solomon H Snyder; Fiscal Year: 2016
    ..Baraban deals with how the translin/trax RNAse complex regulates microRNA processing and responses to cocaine with a focus upon (1) Identifying physiologic ..
  4. GENE EXPRESSION DURING SPERMATOGENESIS
    NORMAN HECHT; Fiscal Year: 2006
    ..In Specific Aim 1 we propose to determine how a TB-RBP interacting protein Trax modulates the nucleic acid binding activity of TB-RBP using transgenesis...
  5. Structural analysis of TB-RBP, a DNA/RNA-binding protein
    Jon Robertus; Fiscal Year: 2005
    ..The protein TRAX has also been expressed...
  6. REGULATION OF REPRODUCTION
    Synthia Mellon; Fiscal Year: 2005
    ..abstract_text> ..
  7. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  8. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....