TRAF3

Summary

Gene Symbol: TRAF3
Description: TNF receptor associated factor 3
Alias: CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor-associated factor 3, CD40 associated protein 1, CD40 binding protein, CD40 receptor associated factor 1, LMP1-associated protein 1, RING-type E3 ubiquitin transferase TRAF3
Species: human

Top Publications

  1. ncbi Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:26243-50. 2004
  2. pmc The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    Sharron A N Brown
    Vascular Biology Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Biochem J 371:395-403. 2003
  3. ncbi Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
    S A Marsters
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080 4918, USA
    J Biol Chem 272:14029-32. 1997
  4. ncbi TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
  5. doi Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation
    Yoon Jae Song
    Department of Life Science, Kyungwon University, Kyeonggi Do, Korea
    Virus Genes 41:174-80. 2010
  6. pmc Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia
    Hui Shien See
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    World J Surg Oncol 6:18. 2008
  7. pmc The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    N Roy
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 16:6914-25. 1997
  8. ncbi T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1)
    Hajir Dadgostar
    Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA
    FEBS Lett 553:403-7. 2003
  9. pmc HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia
    Ritu Mishra
    Laboratory of Neurovirology and Inflammation Biology, Centre for Cellular and Molecular Biology CCMB, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    J Neuroinflammation 9:131. 2012
  10. pmc TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
    Meng Zhang
    Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Immunology, Shandong University School of Medicine, Shandong 250012, China
    J Exp Med 209:1703-11. 2012

Research Grants

  1. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
  2. Yong Jun Liu; Fiscal Year: 2014
  3. TLR-mediated Signaling Complex Formation and Regulation of Effector Functions
    Hans Haecker; Fiscal Year: 2012
  4. Ping Xie; Fiscal Year: 2016
  5. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
  6. The Role of Ubiquitination on TBK1 Function
    Roosevelt Boursiquot; Fiscal Year: 2010
  7. Genhong Cheng; Fiscal Year: 2015
  8. Shen Ying Zhang; Fiscal Year: 2016
  9. Deborah V Novack; Fiscal Year: 2015
  10. Understanding TRAF3-mediated regulation of T lymphocyte functions
    Gail A Bishop; Fiscal Year: 2013

Detail Information

Publications213 found, 100 shown here

  1. ncbi Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:26243-50. 2004
    ..of NIK regulation is through its dynamic interaction with the tumor necrosis factor receptor-associated factor 3 (TRAF3)...
  2. pmc The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    Sharron A N Brown
    Vascular Biology Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Biochem J 371:395-403. 2003
    ..These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor signalling pathway...
  3. ncbi Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
    S A Marsters
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080 4918, USA
    J Biol Chem 272:14029-32. 1997
    ..region of HVEM bound to several members of the TNFR-associated factor (TRAF) family, namely TRAF1, TRAF2, TRAF3, and TRAF5, but not to TRAF6...
  4. ncbi TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
    ..Thus, these two TNFR1-TRADD signaling cascades appear to bifurcate at TRADD...
  5. doi Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation
    Yoon Jae Song
    Department of Life Science, Kyungwon University, Kyeonggi Do, Korea
    Virus Genes 41:174-80. 2010
    ..CTAR2 activates TRAF6, IKKbeta and IKKgamma-dependent canonical NF-kappaB pathway, CTAR1 interacts with TRAF2 and TRAF3 and activates NIK and IKKalpha-dependent alternative NF-kappaB pathway involving p100 processing into functional ..
  6. pmc Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia
    Hui Shien See
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    World J Surg Oncol 6:18. 2008
    ..Less is known about the relationship between these variants and the population characteristics and histological type...
  7. pmc The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    N Roy
    The Burnham Institute, Program on Apoptosis and Cell Death Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 16:6914-25. 1997
    ..Taken together, these findings suggest that c-IAP-1 and c-IAP-2 function similarly to XIAP by inhibiting the distal cell death proteases, caspases-3 and -7, whereas NAIP presumably inhibits apoptosis via other targets...
  8. ncbi T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1)
    Hajir Dadgostar
    Medical Scientist Training Program, University of California Los Angeles, Los Angeles, CA 90095, USA
    FEBS Lett 553:403-7. 2003
    ..During a screen for TRAF3-associated proteins that potentially alter TRAF3 subcellular localization and enable signal transduction, we ..
  9. pmc HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia
    Ritu Mishra
    Laboratory of Neurovirology and Inflammation Biology, Centre for Cellular and Molecular Biology CCMB, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    J Neuroinflammation 9:131. 2012
    ..HIV-1 Tat is known to be secreted from productively infected cells and can affect neighboring uninfected cells by modulating cellular gene expression in a bystander fashion...
  10. pmc TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
    Meng Zhang
    Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Immunology, Shandong University School of Medicine, Shandong 250012, China
    J Exp Med 209:1703-11. 2012
    ..Therefore, we identified TRIP as a negative regulator in TLR3/4- and RIG-I-triggered antiviral responses and suggested TRIP as a potential target for the intervention of diseases with uncontrolled IFN-β production...
  11. ncbi The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1
    Liming Wu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China
    J Biol Chem 281:2162-9. 2006
    ..Although the CTAR1-mediated NF-kappaB activation was previously shown to be TRAF3-dependent, we showed here that the CTAR2-mediated NF-kappaB activation is mainly TRAF6-dependent but TRAF2/5-..
  12. pmc Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
    Zhengfan Jiang
    University of Toronto, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 101:3533-8. 2004
    ..Therefore, double-stranded RNA-induced TLR3/TRIF-mediated NF-kappaB and IRF3 activation diverge at TRIF...
  13. ncbi Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells
    Ming Tsan Liu
    National Health Research Institutes, 3F No 109, Section 6, Min Chuan East Road, Taipei 114, Taiwan
    Oncogene 23:2531-9. 2004
    ..Based on these results, we suggest that disruption of DNA repair by LMP-1 results in an accumulation of unrepaired DNA and consequent genomic instability, which may contribute to the oncogenesis of LMP1 in human epithelial cells...
  14. ncbi A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation
    N T Georgopoulos
    Institute of Molecular Medicine, Epidemiology and Cancer Research, St James s University Hospital, Leeds LS9 7TF, UK
    Cell Death Differ 13:1789-801. 2006
    ..involving rapid upregulation of TNFR-associated factor (TRAF)3 protein, without concomitant upregulation of TRAF3 mRNA, followed by activation of the c-Jun N-terminal kinase (JNK)/activator protein-1 (AP-1) pathway and induction ..
  15. ncbi Involvement of CRAF1, a relative of TRAF, in CD40 signaling
    G Cheng
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Science 267:1494-8. 1995
    ..A yeast two-hybrid screen identified a gene, CRAF1, encoding a protein that interacts directly with the CD40 cytoplasmic tail through a region of similarity to the ..
  16. ncbi The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Cell 80:389-99. 1995
    ..growth transformation and is now shown to interact with a novel human protein (LMP1-associated protein 1 [LAP1])...
  17. ncbi TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor
    H Nakano
    Department of Immunology, Juntendo University, School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:14661-4. 1996
    ..These results show TRAF5 is functionally similar to TRAF2 in that both mediate activation NF-kappaB and implicate TRAF5 as a signal transducer for LT-betaR...
  18. pmc Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
    H Y Song
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 94:9792-6. 1997
    ..Thus, TRAF2 is the bifurcation point of two kinase cascades leading to activation of NF-kappaB and JNK, respectively...
  19. pmc 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
    R H Arch
    Department of Medicine, Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Mol Cell Biol 18:558-65. 1998
    ..While 4-1BB bound TRAF2 and TRAF1, Ox40 interacted with TRAF3 and TRAF2...
  20. ncbi CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase
    H Akiba
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 273:13353-8. 1998
    ..These results indicate that TRAF2 and TRAF5 are involved in NF-kappaB and SAPK/JNK activation by CD27, and NIK is a common downstream kinase of TRAF2 and TRAF5 for NF-kappaB and SAPK/JNK activation...
  21. ncbi CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    S S Pullen
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    Biochemistry 37:11836-45. 1998
    ..TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain...
  22. pmc Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
    N Tsukamoto
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 96:1234-9. 1999
    ..Although four members of the tumor necrosis factor receptor-associated factor (TRAF) family, including TRAF2, TRAF3, TRAF5, and TRAF6, bind to the CD40 cyt, how each TRAF protein contributes to the NFkappaB activation by CD40 is ..
  23. ncbi TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase
    A Hatzoglou
    Laboratory of Experimental Endocrinology, Faculty of Medicine, University of Crete, Heraklion, Greece
    J Immunol 165:1322-30. 2000
    ..performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins...
  24. ncbi Tumor necrosis factor receptor-associated factors (TRAFs)
    J R Bradley
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Oncogene 20:6482-91. 2001
    ..TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes...
  25. ncbi Downstream regulator TANK binds to the CD40 recognition site on TRAF3
    Chenglong Li
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    Structure 10:403-11. 2002
    ..The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the same crevice on TRAF3...
  26. ncbi Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling
    Chenglong Li
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:50523-9. 2003
    ..In this study, the crystal structure of a region of the cytoplasmic domain of LTbetaR bound to TRAF3 has revealed an unexpected new recognition motif, 388IPEEGD393, for TRAF3 binding...
  27. ncbi TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation
    Liusheng He
    Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    J Biol Chem 279:55855-65. 2004
    ..homotypic association of TRAF2, -3, and -5 was observed, as well as heterotypic association of TRAF1-TRAF2 and TRAF3-TRAF5...
  28. ncbi Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation
    Chao Zhou Ni
    Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 173:7394-400. 2004
    ..However, BAFF-R binds only one TRAF adaptor, TRAF3, and this interaction negatively regulates activation of NF-kappaB...
  29. pmc TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
    Julia Hauer
    Institut für Immunologie der Universität München, Goethestrasse 31, 80366 Munich, Germany
    Proc Natl Acad Sci U S A 102:2874-9. 2005
    ..Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. We observed that TRAF3 specifically blocked the NF-kappaB activation via TRAF2/5...
  30. ncbi LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3
    ShuangDing Wu
    Cancer Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:33620-6. 2005
    ..TRAFs are intracellular co-inducers of downstream signaling from CD40 and other TNFRs, and TRAF3 is required for activation of B lymphocytes by LMP1...
  31. pmc Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    Jonathan J Keats
    Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Cancer Cell 12:131-44. 2007
    ..We report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2 and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK that result primarily in constitutive ..
  32. ncbi Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
    Jean Stéphane Gatot
    Interdisciplinary Cluster for Applied Genoproteomics, Medical Chemistry, and Virology Immunology units, University of Liege, Sart Tilman, 4000 Liege, Belgium
    J Biol Chem 282:31131-46. 2007
    ..IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex...
  33. ncbi DUBA: a deubiquitinase that regulates type I interferon production
    Nobuhiko Kayagaki
    Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA
    Science 318:1628-32. 2007
    ..DUBA bound tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response...
  34. pmc The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation
    Peter J Alff
    Molecular and Cellular Biology Graduate Program, SUNY at Stony Brook, Stony Brook, NY 11794, USA
    J Virol 82:9115-22. 2008
    ..The formation of TBK1-TRAF3 complexes directs IRF-3 phosphorylation, and both IRF-3 and NF-kappaB activation are required for transcription ..
  35. pmc The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000650. 2009
    ..through Lys48-linked, ubiquitin-mediated degradation of the tumor necrosis factor receptor-associated factor 3 (TRAF3) adapter...
  36. pmc Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
    Shu Li
    College of Life Sciences, Modern Virology Center, Wuhan University, Wuhan 430072, China
    J Biol Chem 285:4291-7. 2010
    ..Coimmunoprecipitations indicated OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively...
  37. pmc Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response
    Ai Ping Mao
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 285:9470-6. 2010
    ..coimmunoprecipitation experiments indicated that viral infection caused recruitment of cIAP1 and cIAP2 to TRAF3, TRAF6, and VISA...
  38. pmc TRAF5 is a downstream target of MAVS in antiviral innate immune signaling
    Eric D Tang
    Laboratory of Molecular Signalling, Division of Oral Biology and Medicine, University of California Los Angeles School of Dentistry, Los Angeles, California, United States of America
    PLoS ONE 5:e9172. 2010
    ..MAVS dimerization in response to viral RNA, allowing the CARD to bind to and activate the downstream effector TRAF3. Notably, dimerization of the MAVS CARD alone is sufficient to activate IRF3, IRF7, and NF-kappaB...
  39. pmc TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor
    Pradeep Bista
    Department of Immunology, Biogen Idec, Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 285:12971-8. 2010
    Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB...
  40. doi Expanding TRAF function: TRAF3 as a tri-faced immune regulator
    Hans Hacker
    Department of Infectious Diseases, St Jude Childrens Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Immunol 11:457-68. 2011
    ..The function of one TRAF in particular, TRAF3, remained elusive for many years...
  41. pmc ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling
    Linlin Gao
    Department of Microbiology and Immunology, Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:36592-602. 2011
    ..ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi...
  42. pmc Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
    Joanne M Hildebrand
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunol Rev 244:55-74. 2011
    ..In recent years, there has been a resurgence of interest and exploration of the roles played by TRAF3 and TRAF5 in cellular regulation, particularly in cells of the immune system, the cell types of focus in this ..
  43. doi MIP-T3 is a negative regulator of innate type I IFN response
    Ming Him James Ng
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Immunol 187:6473-82. 2011
    ..MIP-T3 interacts specifically with TRAF3, but its function in innate IFN response remains unclear...
  44. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..the non-canonical NF-κB pathway involves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this signalling event is controlled is still unknown...
  45. ncbi A novel RING finger protein interacts with the cytoplasmic domain of CD40
    H M Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 269:30069-72. 1994
    ..This is the first identification of a molecule that interacts with CD40 and whose sequence suggests a potential role in signaling...
  46. ncbi TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 4:387-96. 1996
    ..These results suggest that distinct domains of RIP participate in the TNF signaling cascades leading to apoptosis and NF-kappa B activation...
  47. pmc Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB
    T L VanArsdale
    Division of Biomedical Sciences, University of California, Riverside 92521, USA
    Proc Natl Acad Sci U S A 94:2460-5. 1997
    ..with LT alpha1 beta2 or agonistic LTbeta R antibodies causes rapid recruitment of TNFR-associated factor 3 (TRAF3) to the LTbeta R cytoplasmic domain...
  48. ncbi A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation
    W G van Eyndhoven
    Laboratory of Molecular Immunology, Columbia University, New York, NY 10032, USA
    Mol Immunol 35:1189-206. 1998
    ..Together, these data indicate that a single TRAF-3 gene encodes a variety of mRNA species by a combination of alternative polyadenylation, alternative mRNA splicing and/or alternative initiation...
  49. ncbi MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network
    L Ling
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 275:23852-60. 2000
    In this study, we report the identification of a novel tumor necrosis factor receptor-associated factor 3 (TRAF3)-interacting protein designated MIP-T3. MIP-T3 is a 83-kDa protein with no significant homology to known mammalian proteins...
  50. ncbi Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis
    Jun Kuai
    Musculoskeletal Science and Protein Chemistry and Proteomics, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 278:14363-9. 2003
    ..Four of five proteins identified, TRAF2, TRAF3, cIAP1, and Smac, are reported here...
  51. ncbi Act1, a negative regulator in CD40- and BAFF-mediated B cell survival
    Youcun Qian
    Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 21:575-87. 2004
    ..These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling...
  52. pmc TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    Clare C Davies
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    Mol Cell Biol 25:9806-19. 2005
    ..These observations provide novel insight into the mechanisms of CD40 signaling and the multiple roles played by TRAF6 in signal transduction...
  53. ncbi Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    Gagik Oganesyan
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Dr East, Los Angeles, California 90095, USA
    Nature 439:208-11. 2006
    ..Here we demonstrate that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several ..
  54. ncbi TRAF3: a new regulator of type I interferons
    Supriya K Saha
    Department of Microbiology, Immunology and Molecular Genetics, Medical Scientist Training Program, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cell Cycle 5:804-7. 2006
    ..Interestingly, all of the major viral recognition pathways characterized thus far require TRAF3 to initiate type I interferon production...
  55. pmc Unique signaling properties of CTAR1 in LMP1-mediated transformation
    Bernardo A Mainou
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 81:9680-92. 2007
    ..Dominant-negative forms of TRAF2 and TRAF3 inhibited but did not fully block LMP1-mediated transformation...
  56. pmc Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
    Rebeca Pérez de Diego
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U980, Necker Medical School, Paris, France
    Immunity 33:400-11. 2010
    Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-α (IFN-α), IFN-β, and IFN-λ production, including Toll-like receptor 3 (TLR3), which ..
  57. pmc TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling
    Ping Xie
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 186:143-55. 2011
    ..However, the specific function of TRAF3 in T cells has remained unclear...
  58. pmc Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity
    Wendy J van Zuylen
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec Canada
    PLoS Pathog 8:e1002747. 2012
    Tumor Necrosis Factor receptor-associated factor-3 (TRAF3) is a central mediator important for inducing type I interferon (IFN) production in response to intracellular double-stranded RNA (dsRNA)...
  59. pmc Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response
    Rezaul Karim
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS Pathog 9:e1003384. 2013
    ..UCHL1 accomplished this by inhibiting tumor necrosis factor receptor-associated factor 3 (TRAF3) K63 poly-ubiquitination which lead to lower levels of TRAF3 bound to TANK-binding kinase 1 and a reduced ..
  60. ncbi Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
    K P Hoeflich
    Department of Medical Biophysics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Oncogene 18:5814-20. 1999
    ..Hence, ASK1 is a common mediator of TRAF-regulated SAPK and apoptosis signaling, and the TRAF2 - ASK1 connection completes the signaling cascade from TNF to SAPK/JNK activation...
  61. pmc Molecular basis for CD40 signaling mediated by TRAF3
    C Z Ni
    Cancer Center, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:10395-9. 2000
    ..crystal structure of a 20-residue fragment from the cytoplasmic domain of CD40 in complex with the TRAF domain of TRAF3. The CD40 fragment binds as a hairpin loop across the surface of the TRAF domain...
  62. ncbi Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation
    Ying Hsin Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Exp Cell Res 278:166-74. 2002
    ..This suggests that IL-8 induction by LTbetaR is via TRAFs-elicited signaling pathways, including NIK/IKK-dependent NF-kappaB activation and ASK/MKK/JNK-dependent AP-1 activation...
  63. pmc Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
    Supriya K Saha
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA
    EMBO J 25:3257-63. 2006
    ..Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA...
  64. ncbi TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase
    Arnaud Besse
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Box 143, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochem Biophys Res Commun 359:660-4. 2007
    ..Interestingly, TRIP expression was down regulated during the late stages of osteoclastogenesis. Taken together, our results demonstrate that TRIP is a novel RING-dependent Ub ligase and a binding partner for TRAFs...
  65. pmc Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection
    Jamel Mankouri
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
    PLoS Pathog 6:e1000778. 2010
    ..identified optineurin in a protein complex containing the antiviral protein kinase TBK1 and the ubiquitin ligase TRAF3. Furthermore, mutagenesis studies determined that binding of ubiquitin was essential for both the correct sub-..
  66. ncbi Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family
    S Krajewski
    The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 159:5841-52. 1997
    ..The findings establish for the first time the cell type- and differentiation-specific patterns of expression of a member of the TRAF family of proteins...
  67. ncbi Protein-protein interactions in TRAF3
    Kathryn R Ely
    The Burnham Institute, La Jolla, California 92037, USA
    Adv Exp Med Biol 597:114-21. 2007
    ..For example, CD40 binds to TRAF2, TRAF3 and TRAF6 to control B cell differentiation, proliferation and growth...
  68. ncbi Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation
    Frank Henkler
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart, Germany
    J Biol Chem 278:29216-30. 2003
    ..In contrast, a corresponding fragment generated by cleavage of TRAF3 showed no effect in this regard...
  69. ncbi The influence of bladder volume on the position and mobility of the urethrovesical junction
    H P Dietz
    Dunedin School of Medicine, University of Otago, New Zealand
    Int Urogynecol J Pelvic Floor Dysfunct 10:3-6. 1999
    ..Funneling of the proximal urethra, however, is more easily observed with a full bladder. Imaging of the lower urinary tract should be undertaken at defined bladder volumes...
  70. pmc TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway
    A I Chin
    Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 90095, USA
    Mol Cell Biol 19:6665-72. 1999
    ..Here we show that TANK synergized with TRAF2, TRAF5, and TRAF6 but not with TRAF3 in SAPK activation...
  71. pmc Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein
    K M Kaye
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:11085-90. 1996
    ..virus transforming protein, associates with tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) and TRAF3. Since TRAF2 has been implicated in TNFR-mediated NF-kappa B activation, we have evaluated the role of TRAF2 in ..
  72. pmc Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway
    M Kashiwada
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    J Exp Med 187:237-44. 1998
    ..The CD40 cytoplasmic tail interacts with tumor necrosis factor receptor-associated factor (TRAF)2, TRAF3, TRAF5, and TRAF6. These TRAF proteins, with the exception of TRAF3, are required for NF kappa B activation...
  73. pmc TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
    T K Ishida
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:9437-42. 1996
    ..factor (TRAF) domain in its carboxyl terminus and is most homologous to TRAF3, also known as CRAF1, CD40bp, or LAP-1, a previously identified CD40-associated factor...
  74. doi TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells
    Feng Guo
    The First Affiliated Hospital of Soochow University, Suzhou, PR China
    Mol Immunol 46:2441-8. 2009
    ..We report that all TRAFs except TRAF3 are expressed at mRNA and protein levels in B cell-derived Hodgkin's lymphoma cell lines (L428 and KM-H2)...
  75. ncbi TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
    ..Overexpression of TRAF2, but not TRAF1 or TRAF3, was sufficient to induce NF-kappa B activation...
  76. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
    ..wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice...
  77. ncbi An 11-amino acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun N-terminal kinase, activation of MAPKAP kinase-2, phosphorylation of I kappa B alpha, and protection of WEHI-231 cells from anti-IgM-induced growth arrest
    C L Sutherland
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Immunol 162:4720-30. 1999
    ..This is the same region of CD40 required for binding the TNF receptor-associated factor-2 (TRAF2), TRAF3, and TRAF5 adapter proteins...
  78. pmc Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
    H H Lee
    Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 96:1421-6. 1999
    Several tumor necrosis factor receptor-associated factor (TRAF) family proteins including TRAF2, TRAF3, TRAF5, and TRAF6, as well as Jak3, have been implicated as potential mediators of CD40 signaling...
  79. pmc The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinase
    Dang Wang
    Laboratory of Infectious Diseases, College of Veterinary Medicine, Huazhong Agricultural University, 1 Shi zi shan Street, Wuhan 430070, China
    J Virol 85:3758-66. 2011
    ..acid-inducible gene I (RIG-I), TANK-binding kinase 1 (TBK1), TNF receptor-associated factor 6 (TRAF6), and TRAF3, key signaling molecules in activation of type I IFN response...
  80. ncbi Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:5546-55. 2004
    ..The present study further investigated how TRAF3 participates in LMP1 signaling...
  81. ncbi Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 176:5388-400. 2006
    ..an increased amount of TRAF2 was recruited to lipid rafts, and subsequently, more robust degradation of TRAF2 and TRAF3 was induced in response to CD40 signaling...
  82. pmc Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
    Hideki Sanjo
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Biol Chem 285:17148-55. 2010
    ..We found that insertion of a charge-repulsion mutation in the receptor-binding crevice of TRAF3 ablated binding of both LTbetaR and NIK suggesting a common recognition site...
  83. ncbi Intestinal microcirculation and gut permeability in acute pancreatitis: early changes and therapeutic implications
    H G Hotz
    Department of Surgery, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    J Gastrointest Surg 2:518-25. 1998
    ....
  84. ncbi Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway
    Jeannie Q He
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 282:3688-94. 2007
    ..Whereas TRAF2, 5, and 6 are activators of the canonical NF-kappaB signaling pathway, TRAF3 is an inhibitor of the noncanonical NF-kappaB pathway...
  85. doi Solea senegalensis genes responding to lipopolysaccharide and copper sulphate challenges: large-scale identification by suppression subtractive hybridization and absolute quantification of transcriptional profiles by real-time RT-PCR
    María José Prieto-Alamo
    University of Cordoba, Department of Biochemistry and Molecular Biology, Spain
    Aquat Toxicol 91:312-9. 2009
    ..components), and ferritin M, HP and TF (iron homeostasis), or play a crucial role in its regulation, like TRAF3. Other mRNAs studied encode proteins involved in metabolism, like TKT and NDUFA4, the response to stimulus, like ..
  86. pmc Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment
    Michael Imbeault
    Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec CHUL, 2705 Boul Laurier, Quebec, Canada
    J Virol 85:2189-200. 2011
    ..factors and associated proteins (NFKB1, NFKBIA, NFKBIE), second messengers involved in CD40 signaling (TRAF1, TRAF3, MAP2K1, phosphatidylinositol 3-kinase), and the activation-induced cytidine deaminase (AID) were identified...
  87. ncbi [Study of gene expression difference in lung carcinogenesis by cDNA microarray]
    Zai Mei Peng
    Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Ai Zheng 23:150-4. 2004
    ....
  88. ncbi RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
    J V McCarthy
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    J Biol Chem 273:16968-75. 1998
    ..cIAP1 and with members of the TNFR-associated factor (TRAF) family, specifically TRAF1, TRAF5, and TRAF6, but not with TRAF2, TRAF3, or TRAF4. These TRAF interactions mediate the recruitment of RIP2 to receptor signaling complexes.
  89. ncbi TRAF3 and its biological function
    Jeannie Q He
    Department of Microbiology, Immunology and Molecular Genetics, 8University of California, Los Angeles, Los Angeles, California 90095, USA
    Adv Exp Med Biol 597:48-59. 2007
    Tumor necrosis factor receptor associated factor 3 (TRAF3) is one of the most enigmatic members in the TRAF family that consists of six members, TRAF1 to 6...
  90. doi Expression profiles of carp IRF-3/-7 correlate with the up-regulation of RIG-I/MAVS/TRAF3/TBK1, four pivotal molecules in RIG-I signaling pathway
    Hong Feng
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Fish Shellfish Immunol 30:1159-69. 2011
    ..acid-inducible gene I) and downstream signaling molecules, MAVS (mitochondrial antiviral signaling protein), TRAF3 (TNF-receptor-associated factor 3) and TBK1 (TANK-binding kinase 1), have significant roles in the recognition of ..
  91. pmc Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity
    Etienne Decroly
    Architecture et Fonction des Macromolecules Biologiques, CNRS and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, 13288 Marseille, France
    J Virol 82:8071-84. 2008
    ....
  92. ncbi CD40-mediated activation of NF-kappa B in airway epithelial cells
    Stacie M Propst
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 277:37054-63. 2002
    ..Stable transfectants expressing wild-type or mutant forms of the cytoplasmic domain of CD40 suggested that TRAF3, but not TRAF2, binding was essential for CD40-mediated RANTES expression...
  93. doi TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway
    Alfonso Lavorgna
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Naples, Italy
    Mol Immunol 46:3278-82. 2009
    ..Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52...
  94. pmc RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis
    Etienne Meylan
    Institute of Biochemistry, University of Lausanne, 155 Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    EMBO Rep 3:1201-8. 2002
    ..RIP4 binds to several members of the TRAF protein family, and DN versions of TRAF1, TRAF3 and TRAF6 inhibit RIP4-induced NF-kappa B activation...
  95. ncbi Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K
    Rebecca J Benson
    Medical Scientist Training Program and Immunology Graduate Program, University of Iowa and Veterans Affairs Medical Center, Iowa City 52245, USA
    Eur J Immunol 36:2535-43. 2006
    ..Signaling via a CD40 mutant that does not bind TNFR-associated factor (TRAF)1, TRAF2, and TRAF3 rescued B cells from CD95-induced apoptosis...
  96. pmc Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer
    Juan M Zapata
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Blood 113:4595-603. 2009
    Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) regulates both innate and adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors...
  97. pmc Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex
    Kam Leung Siu
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong
    J Biol Chem 284:16202-9. 2009
    ..M protein physically associates with RIG-I, TBK1, IKKepsilon, and TRAF3 and likely sequesters some of them in membrane-associated cytoplasmic compartments...
  98. pmc Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways
    Samer Swedan
    Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd, Mobile, AL 36688 0002, USA
    J Virol 83:9682-93. 2009
    ..We found that both NS1 and NS2 decreased the levels of TRAF3, a strategic integrator of multiple IFN-inducing signals, although NS1 was more efficient...
  99. ncbi Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray
    K Heikinheimo
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Lemminkaisenkatu 2, FIN 20520 Turku, Finland
    J Dent Res 81:525-30. 2002
    ..Genes for sonic hedgehog (SHH), TNF-receptor-associated-factor 3 (TRAF3), rhoGTP-ase-activating protein 4 (ARHGAP4), deleted in colorectal carcinoma (DCC), cadherins 12 and 13 (CDH12 and ..
  100. ncbi The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts
    Jeffrey M Purkerson
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Immunol 35:2920-8. 2005
    ..amino acids of the CD40ct encompassing the TRAF6 binding site (1-35), and amino acids 35-53 containing the TRAF2/TRAF3 binding domain were expressed in human lung fibroblasts as fusion proteins with the extracellular domain of human ..
  101. pmc IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3
    Yoon Jae Song
    Department of Microbiology, Channing Laboratory Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:18448-53. 2008
    ..IRF7 activation required TRAF6 and RIP1, but not TRAF2 or TRAF3. LMP1 Y(384)YD(386), which are required for TRADD and RIP1 binding and for NF-kappaB activation, were not required ..

Research Grants57

  1. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ..We, recently, have shown that the tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) is a critical negative modulator of type II NF- kappa B pathway and TRAF3 knock out (TRAF3-/-) have constitutive ..
  2. Yong Jun Liu; Fiscal Year: 2014
    ..Engagement of TLR9 by CpG-A oligodeoxynucleotide (ODN) in the early endosomes preferentially triggers the TRAF3/IRAK1/IKK1/PI3K/IRF7 signal cascade leading to type 1 IFN responses, whereas engagement of TLR9 by CpG-B ODN in ..
  3. TLR-mediated Signaling Complex Formation and Regulation of Effector Functions
    Hans Haecker; Fiscal Year: 2012
    ..We have demonstrated the proof of principle for this approach by identifying TRAF3 as a critical component of TLR signaling pathways...
  4. Ping Xie; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): TRAF3 is a novel tumor suppressor gene identified in a variety of human B lymphoma, including splenic marginal zone lymphoma, B cell chronic lymphocytic leukemia and mantle cell lymphoma, as well as ..
  5. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..investigate the molecular mechanisms that link BAFF-R to Btk at the level of cIAP2 and TRAF2 and modifications to TRAF3 and NF-kB inducing kinase (NIK) (Aim 1)...
  6. The Role of Ubiquitination on TBK1 Function
    Roosevelt Boursiquot; Fiscal Year: 2010
    ..Sequence analysis of TRAF3, another TRAF family member, reveals that it contains a RING finger domain...
  7. Genhong Cheng; Fiscal Year: 2015
    ..Surprisingly, we have found that while TNF receptor associated factor 3 (TRAF3) deficient cells are defective in IFN induction in response to RNA viral infections, they ..
  8. Shen Ying Zhang; Fiscal Year: 2016
    ..We recently discovered an AR form of TLR3 deficiency, as well as AD TRIF, TRAF3 and TBK1 defects (unpublished)...
  9. Deborah V Novack; Fiscal Year: 2015
    ..Recently, cIAP and TRAF3 have been implicated as critical negative regulators of NIK, and thus RelB...
  10. Understanding TRAF3-mediated regulation of T lymphocyte functions
    Gail A Bishop; Fiscal Year: 2013
    ..During the >15 years since its discovery, the number of receptors for which TRAF3 plays important roles has grown considerably, including members of the TNFR-superfamily (TNFR-SF), certain ..
  11. MECHANISMS OF IGE SYNTHESIS BY B CELLS
    Raif Geha; Fiscal Year: 2007
    ..IC) domain of CD40 has a binding site for Jak3, one for TRAF6 and one for the TRAF proteins TRAF2 and TRAF3 (TRAF2/3 site)...
  12. Shao Cong Sun; Fiscal Year: 2016
    ..that activation of the noncanonical NF-[unreadable]B pathway involves degradation of an inhibitory protein, TRAF3, and stabilization of the NF-[unreadable]B-inducing kinase (NIK)...
  13. Role of TRAF1 in signaling by TNFR2 family members
    Erdyni Tsitsikov; Fiscal Year: 2007
    ..Each of TNFR2 family receptors may associate with one or several TRAF signal transduction molecules. TRAF2, TRAF3, TRAF5, and TRAF6 were shown to participate in signal transduction and activation of NF-kappaB and AP-1 ..
  14. CHROMOSOMAL ABNORMALITIES IN MYELOMA AS DETECTED BY FISH
    Rafael Fonseca; Fiscal Year: 2013
    ..Can bortezomib result in better responses and outcome in patients with HR-MM? 4. Can NF-kB hyperactivation or TRAF3 inactivation predict improved outcome with bortezomib? 5...
  15. Translational partitioning of the SL RNA
    David A Campbell; Fiscal Year: 2010
    ..tarentolae, which generally exhibit the cap 1 phenotype, is that they are recognized by the translational masking factor, but cannot be unmasked...
  16. Weizhou Zhang; Fiscal Year: 2014
    ..of alternative NF-[unreadable]B pathways components, including NF-[unreadable]B inducing kinase (NIK), TRAF2, and TRAF3 in ErbB2-induced mammary tumor development and metastasis;and identify upstream members, if other than RANKL that ..
  17. DIFFERENTIATION AND FUNCTION OF HUMAN HELPER T CELLS
    SETH LEDERMAN; Fiscal Year: 2000
    ..own, of a critical signalling element in the CD4O pathway, termed CD40-receptor associated factor 1 (CRAF1, LAP1, CD40bp)...
  18. Genes in X-linked Ectodermal Dysplasia Receptor
    PREET CHAUDHARY; Fiscal Year: 2006
    ..We have characterized the signaling pathways activated by XEDAR and discovered that it binds to TRAF3 and TRAF6 in a ligand-dependent fashion and activates the NF-kappaB and JNK pathways...
  19. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    ..Preliminary data are presented that show that in a human B-cell line both TRAF2 and TRAF3 are recruited to the CD40 receptor complex within minutes of ligand binding...
  20. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..toward alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  21. RICHARD LOWELL BELL; Fiscal Year: 2014
    ..This approach is most expedient because Dr. Ting-Kai Li (the PI who created our P/NP, HAD1-2/LAD1-2, and HAP1-2/LAP1-2 selected rodent lines) is now a Professor of Psychiatry at Duke and Drs. Amir H. Rezvani and Edward D...
  22. MICHAEL FINLEY SUMMERS; Fiscal Year: 2015
    ..abstract_text> ..
  23. CD40 SIGNAL TRANSDUCTION
    Claudius Vincenz; Fiscal Year: 1999
    ..One such interacting protein, designated CD40-binding protein (CD40bp), has a N- terminal RING finger motif and a prominent central coiled-coil segment that may allow homo- or hetero-..
  24. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..The proposed research is expected to help transform this ideal into a reality. ..
  25. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
    ..in silencing ICPO expression (iv) To characterize cis-acting elements associated with two LAT promoters designated LAP1 and LAP2. (v) To determine the role of chromatin and DNA methylation in promoter silencing during latency...
  26. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    ....
  27. EXOGENOUS INDUCTION OF THE E.COLI UHPT GENE
    ROBERT KADNER; Fiscal Year: 2004
    ..These studies should provide new information on transmembrane signal transduction coupled between two membrane proteins. ..
  28. CLINICAL SCALE EXPANSION OF HUMAN DENDRITIC CELLS
    Douglas Smith; Fiscal Year: 2001
    ..The development of a fully automated DC culture process will enable widespread application of successful dendritic cell-based immunotherapies in a reliable and cost- effective fashion. ..
  29. QTL MAPPING FOR ALCOHOL PREFERENCE IN SELECTED MICE
    Paula Bice; Fiscal Year: 2004
    ..we also propose to do a fun genome screen to search for novel QTLs by using F2 animals generated from a HAP1 X LAP1 cross...
  30. Role of Cysteine-rich Protein 2 in Vascular Disease
    Shaw Fang Yet; Fiscal Year: 2005
    ..We hypothesize that CAP 1, a closely related protein that is expressed in SMC, may also contribute to the vascular remodeling...
  31. Capsid assembly inhibitors for the treatment of AIDS
    Atul Agarwal; Fiscal Year: 2006
    ..Phase II of the project will entail further lead optimization and identification of development candidate(s). ..
  32. Integrating Aging and Cancer Research
    Robert Wallace; Fiscal Year: 2007
    ..Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development. ..
  33. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009
    ..abstract_text> ..
  34. TRAF Regulation and Receptor Interactions in TNFR Family Signals
    GAIL BISHOP; Fiscal Year: 2009
    ..To explore the role of TRAF5 in B cell activation. ..
  35. Measuring the Aversive Effects of Alcohol Withdrawal
    JULIA CHESTER; Fiscal Year: 2006
    ..Studies using this place conditioning technique are likely to provide important information that will lead to the development of novel behavioral and pharmacological treatments for alcoholism. ..
  36. NIK KINASE AND T CELL COSTIMULATION
    Shao Cong Sun; Fiscal Year: 2003
    ..It is also expected that novel signaling molecules will have been isolated which function in the T cell co-stimulatory pathway. ..
  37. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2003
    ..abstract_text> ..
  38. How Anthrax lethal factor kills activated macrophages
    Michael Karin; Fiscal Year: 2003
    ..anthracis and its host, this project should enable the design of new therapeutic strategies that will tilt the balance in favor of the host macrophage in the battle against B. anthracis and inhalation anthrax. ..
  39. DEXASOME BASED IMMUNOTHERAPY OF LUNG CANCER
    Michael Morse; Fiscal Year: 2002
    ..This clinical trial will form the background for further trials designed to demonstrate both immunology and clinical benefits of dexosome-based immunotherapy. ..
  40. RANK/NF-KappaB signaling in chondrogenesis
    BRENDAN BOYCE; Fiscal Year: 2003
    ....
  41. Regulation of Beta-Defensin Expression in Oral Epithelia
    WHASUN CHUNG; Fiscal Year: 2009
    ..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
  42. Molecular Mechanisms for IL-25-mediated Th2 Responses
    Xiaoxia Li; Fiscal Year: 2010
    ..With this improved understanding comes the potential to develop specific inhibitors of these pathways and perhaps novel therapeutics for the treatment of asthma. ..
  43. Functions and Mechanisms of Radiation Induced Responses
    Michael Karin; Fiscal Year: 2006
    ..abstract_text> ..
  44. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Encoded by an intronless gene, C/EBPB is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) whose expression is tightly regulated by the differential use of a number of in-frame translation ..
  45. SIGIRR A Negative Regulator of Toll-IL-IR Signaling
    Xiaoxia Li; Fiscal Year: 2009
    ..Specifically, the proposed studies should result in significant advances in the field of innate mucosal immunity and should also help us to determine the potential of SIGIRR as a target for developing anti-inflammatory drugs. ..
  46. Act1 in CD40-/BAFFR-Mediated B Cell Survival
    Xiaoxia Li; Fiscal Year: 2009
    ..These findings will help us to elucidate the detailed regulatory mechanism for B cell homeostasis and opens new possibility to intervene the immune system. ..
  47. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2007
    ..abstract_text> ..
  48. Molecular Mechanisms of IL-1R-TLR-Mediated Signaling
    Xiaoxia Li; Fiscal Year: 2008
    ..The long-term objective is to develop more effective anti-inflammatory and anti-atherogenic small molecule drugs. [unreadable] [unreadable] [unreadable]..
  49. Epithelial Innate Immune Response to Oral Bacteria
    WHASUN CHUNG; Fiscal Year: 2008
    ..This work will lay the groundwork for identifying new therapeutic targets to prevent and treat periodontal diseases. [unreadable] [unreadable]..
  50. How Anthrax lethal factor kills macrophages
    Michael Karin; Fiscal Year: 2008
    ..Interference with this activation process may be used to increase host resistance to bacterial infections, both with agents of bioterrorism and more common pathogens. ..
  51. Vaccination with Regulatory T Cell Depletion
    Michael Morse; Fiscal Year: 2007
    ..Future studies will assess whether the greater magnitude and durability of the CEA-specific immune responses will translate into a long-term clinical benefit. [unreadable] [unreadable] [unreadable]..
  52. 2007 Bones and Teeth Gordon Research Conference
    BRENDAN BOYCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  53. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
  54. INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    Michael Karin; Fiscal Year: 2007
    ..As NF-KB plays a key role in inflammation, understanding the regulation of IKK activity by oxidants, such as ozone, will provide a molecular basis for oxidant induced inflammatory disease. ..
  55. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  56. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..