TPSB2

Summary

Gene Symbol: TPSB2
Description: tryptase beta 2 (gene/pseudogene)
Alias: TPS2, tryptaseB, tryptaseC, tryptase beta-2, mast cell tryptase beta II, mast cell tryptase beta III, testicular tissue protein Li 163
Species: human

Top Publications

  1. ncbi Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils
    Liao Chang-Hui
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, No 259 Wen Hwa 1st Road, Kwei Shan, 333, Tao Yuan, Taiwan, ROC
    Eur J Pharmacol 484:29-39. 2004
  2. pmc Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 115:401-8. 1995
  3. ncbi Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis
    Hejin P Hahn
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1669-76. 2007
  4. ncbi Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani
    S Bhattacharyya
    Department of Microbiology, Bose Institute, Calcutta, India
    Mol Cell Biochem 216:47-57. 2001
  5. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
  6. ncbi Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population
    M Rottem
    Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Blood 84:2489-96. 1994
  7. ncbi Identification and characterization of protein kinase C zeta-immunoreactive proteins
    B G Allen
    Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Biol Chem 269:29288-98. 1994
  8. ncbi Antisense oligodeoxynucleotide to PKC-delta blocks alpha 1-adrenergic activation of Na-K-2Cl cotransport
    C M Liedtke
    Cystic Fibrosis Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol 273:C1632-40. 1997
  9. pmc Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma
    N G Carroll
    Faculty of Regional Professional Studies, Edith Cowan University, Bunbury 6230, Australia
    Thorax 57:677-82. 2002
  10. ncbi Differential activation of PKC-delta and -zeta by alpha 1-adrenergic stimulation in human airway epithelial cells
    C M Liedtke
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106-4948, USA
    Am J Physiol 273:C937-43. 1997

Research Grants

  1. Praveen Thumbikat; Fiscal Year: 2016
  2. Matthew J Hamilton; Fiscal Year: 2016
  3. The effect of pathological mutations in beta-III tubulin on microtubules and axon
    ADRIANNE LYNN KOLPAK; Fiscal Year: 2012
  4. RECOMBINANT HUMAN MAST CELL TRYPTASES
    David Johnson; Fiscal Year: 2000
  5. MECHANISM OF HUMAN MAST CELL TRYPTASE REGULATION
    Norman Schechter; Fiscal Year: 2003
  6. Kalpna Gupta; Fiscal Year: 2016
  7. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 2002
  8. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
  9. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
  10. PAR2, Bronchopulmonary Sensory Nerve and Pathogenesis of Asthma
    Qihai Gu; Fiscal Year: 2009

Detail Information

Publications291 found, 100 shown here

  1. ncbi Celecoxib simulates respiratory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils
    Liao Chang-Hui
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, No 259 Wen Hwa 1st Road, Kwei Shan, 333, Tao Yuan, Taiwan, ROC
    Eur J Pharmacol 484:29-39. 2004
    ..Celecoxib also regulates beta(2)-integrin expression through superoxide anion release, tyrosine kinase and p42/p44 MAP kinase on human neutrophils...
  2. pmc Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 115:401-8. 1995
    ....
  3. ncbi Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis
    Hejin P Hahn
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 31:1669-76. 2007
    ..Aggregates or sheets of mast cells are only seen in SM. Immunoreactivity for CD25 in GI mucosal mast cells is specific for SM and can be used to confirm the diagnosis...
  4. ncbi Selective impairment of protein kinase C isotypes in murine macrophage by Leishmania donovani
    S Bhattacharyya
    Department of Microbiology, Bose Institute, Calcutta, India
    Mol Cell Biochem 216:47-57. 2001
    ..Taken together, our observations revealed that infection with L. donovani selectively attenuates both the expression and activity of Ca-dependent PKC beta...
  5. ncbi Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton
    J Gomez
    Centro de Investigaciones Biologicas, Madrid, Spain
    Eur J Immunol 25:2673-8. 1995
    ..On the contrary, zeta PKC is not involved in the actin cytoskeleton organization when cells are maintained in IL-4, confirming our previous results showing that IL-4-induced signal transduction is PKC independent...
  6. ncbi Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population
    M Rottem
    Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Blood 84:2489-96. 1994
    ....
  7. ncbi Identification and characterization of protein kinase C zeta-immunoreactive proteins
    B G Allen
    Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Biol Chem 269:29288-98. 1994
    ..The first peak exhibited regulatory properties characteristic of PKC alpha, whereas the second peak (PKC alpha') exhibited constitutive activity. PKC alpha' appears to be derived from PKC alpha by irreversible oxidative modification...
  8. ncbi Antisense oligodeoxynucleotide to PKC-delta blocks alpha 1-adrenergic activation of Na-K-2Cl cotransport
    C M Liedtke
    Cystic Fibrosis Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol 273:C1632-40. 1997
    ..These results demonstrate the selective activation of Na-K-2Cl cotransport by cytosolic PKC-delta...
  9. pmc Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma
    N G Carroll
    Faculty of Regional Professional Studies, Edith Cowan University, Bunbury 6230, Australia
    Thorax 57:677-82. 2002
    ..A study was undertaken to count the mast cells and neutrophils in submucosal glands and to relate cell numbers to the presence of mucus in the airway lumen...
  10. ncbi Differential activation of PKC-delta and -zeta by alpha 1-adrenergic stimulation in human airway epithelial cells
    C M Liedtke
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio 44106-4948, USA
    Am J Physiol 273:C937-43. 1997
    ..Methoxamine selectively induced a sustained increase in PKC-zeta activity but only a transient increase in PKC-delta. These results suggest that PKC-delta and -zeta mediate hormonal activation of Na-Cl-K cotransport...
  11. ncbi Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit
    H Tei
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 83:916-25. 1994
    ..The normal signal transduction through the c-kit receptor did not appear to be prerequisite for the acquisition of the RMCP-I+/II+ phenotype...
  12. ncbi Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2
    Grant R Stenton
    Pulmonary Research Group, Department of Medicine, Astra Zeneca Canada Inc, Glaxo Heritage Asthma Research Laboratory, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Pharmacol Exp Ther 302:466-74. 2002
    ..The responsiveness of mast cells to PAR-AP via a non-PAR-1/non-PAR-2 mechanism complicates the interpretation of in vivo studies using these peptides...
  13. ncbi The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C
    Tianyan Gao
    Department of Pharmacology, University of California, La Jolla, California 92093 0640, USA
    J Biol Chem 277:31585-92. 2002
    ..Disruption of this interaction prevents re-phosphorylation and targets the enzyme for down-regulation...
  14. doi Systemic mastocytosis involving the gastrointestinal tract: clinicopathologic and molecular study of five cases
    Richard Kirsch
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Mod Pathol 21:1508-16. 2008
    ..Systemic mastocytosis involving the gastrointestinal tract is associated with the usual D816V KIT mutation...
  15. ncbi Identification of nuclear beta II protein kinase C as a mitotic lamin kinase
    V L Goss
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    J Biol Chem 269:19074-80. 1994
    ....
  16. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    ..We assessed colonic mast cell infiltration, mediator release, and spatial interactions with mucosal innervation and their correlation with abdominal pain in IBS patients...
  17. ncbi A pilot study of fecal serine-protease activity: a pathophysiologic factor in diarrhea-predominant irritable bowel syndrome
    Richard Roka
    Institut National de la Recherche Agronomique, Neuro Gastroenterology and Nutrition Unit, Toulouse, France
    Clin Gastroenterol Hepatol 5:550-5. 2007
    ..Our study was designed to evaluate if colonic luminal serine-proteases may be a relevant pathophysiologic marker of IBS...
  18. ncbi Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice
    P J Vig
    Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Neurol Sci 174:100-10. 2000
    ..Further, we speculate that ataxin-1 aggregates may not be toxic in general; however, they may deplete specific proteins essential for Purkinje cell viability in SCA-1 TM...
  19. pmc Mast cells: the forgotten cells of renal fibrosis
    I S Roberts
    Department of Cellular Pathology, Level 1, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    J Clin Pathol 53:858-62. 2000
    ..Therefore, the numbers of mast cells in normal and fibrotic kidneys with various pathologies were investigated...
  20. pmc Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat
    Yinghua Zhang
    Department of Physiology, University of Maryland, School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
    J Mol Cell Cardiol 48:1050-9. 2010
    ..Our results suggest that the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth...
  21. ncbi Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis
    T Ehara
    First Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan
    Kidney Int 54:1675-83. 1998
    ..Mast cells have been found to secrete basic fibroblast growth factor (bFGF) in human pulmonary fibrosis...
  22. ncbi Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta
    Roselia M Spanevello
    Pós Graduação em Bioquímica Toxicológica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitario, Camobi, 97105 900 Santa Maria, RS, Brazil
    Life Sci 80:1109-14. 2007
    ..In conclusion, our study demonstrated that the hydrolysis of adenine nucleotides is modified in platelets of rats demyelinated and treated with IFN-beta...
  23. doi Local production of total IgE and specific antibodies to the house dust mite in adenoid tissue
    Seung Youp Shin
    Department of Otorhinolaryngology, College of Medicine, Kyunghee University, Seoul, Korea
    Pediatr Allergy Immunol 20:134-41. 2009
    ..In conclusion, locally-produced total IgE and DP-specific antibodies may contribute to eosinophilic inflammation in adenoid tissue in atopic children...
  24. doi Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis
    Desmond G Powe
    Department of Histopathology, Surgical and Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham NG7 2UH, United Kingdom
    J Allergy Clin Immunol 125:139-45.e1-3. 2010
    ..Recent murine studies suggest the existence of an IgE-independent hypersensitivity response involving antigen-induced mast cell activation, mediated by immunoglobulin free light chains (FLCs)...
  25. pmc Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin
    Konrad Pazdrak
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 186:6485-96. 2011
    ....
  26. doi Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients
    Sari Riihijärvi
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Mod Pathol 23:686-93. 2010
    ..Together, the data show that protein kinase C-beta II expression has prognostic significance in diffuse large B-cell lymphoma patients treated with immunochemotherapy...
  27. pmc The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii
    Popchai Ngamskulrungroj
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Infect Immun 77:4584-96. 2009
    ..Three genes putatively involved in trehalose biosynthesis, TPS1 (trehalose-6-phosphate [T6P] synthase) and TPS2 (T6P phosphatase), and degradation, NTH1 (neutral trehalose), were deleted in this strain, creating the R265tps1 ..
  28. ncbi [The molecular composition and spectral properties of polysaccharide isolated from pu-erh tea and its material]
    Jia Shun Gong
    College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China
    Guang Pu Xue Yu Guang Pu Fen Xi 30:1960-4. 2010
    ..The main polysaccharide TPS2 and TPS1 were isolated and purified from pu-erh tea and its materials by DEAE-52 and Sephadex G-150 column ..
  29. ncbi Interactions of mast cell tryptase with thrombin receptors and PAR-2
    M Molino
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:4043-9. 1997
    ..Tryptase is the first protease other than trypsin that has been shown to activate human PAR-2. Its presence within mast cell granules places it in tissues where PAR-2 is expressed but trypsin is unlikely to reach...
  30. doi Hyperexpression of the high-affinity IgE receptor-beta chain in chronic allergic keratoconjunctivitis
    Akira Matsuda
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 50:2871-7. 2009
    ....
  31. ncbi The orlA gene from Aspergillus nidulans encodes a trehalose-6-phosphate phosphatase necessary for normal growth and chitin synthesis at elevated temperatures
    P T Borgia
    Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield 62794 1120, USA
    Mol Microbiol 20:1287-96. 1996
    ..Da) that is homologous to a 211-amino-acid domain from the polypeptide encoded by the Saccharomyces cerevisiae TPS2 gene and to almost the entire Escherichia coli otsB-encoded polypeptide...
  32. ncbi On the in vitro biocompatibility of Elgiloy, a co-based alloy, compared to two titanium alloys
    Martha Es-Souni
    Department of Orthodontics, University of Kiel, Germany
    J Orofac Orthop 64:16-26. 2003
    ....
  33. ncbi Stem cell factor in a rat model of serum nephrotoxic nephritis
    M M El Kossi
    Sheffield Kidney Institute, University of Sheffield, Sheffield, UK
    Nephron Exp Nephrol 108:e1-e10. 2008
    ..The growth factor (SCF) was evaluated in a rat model of nephrotoxic serum nephritis (NTN), characterized by early inflammation followed by later tissue fibrosis...
  34. doi Lymphocyte sub-populations and non-Langerhans' cell monocytoid cells in pulmonary Langerhans' cell histiocytosis
    R Nagarjun Rao
    Department of Pathology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pathol Res Pract 204:315-22. 2008
    ..A small sub-population of NLMC was also present. Further studies are required to better define and to evaluate the role of cytotoxic T cells and NLMC in the pathogenesis of PLCH...
  35. doi Class III beta-tubulin is constitutively coexpressed with glial fibrillary acidic protein and nestin in midgestational human fetal astrocytes: implications for phenotypic identity
    Eduarda Dráberová
    Laboratory of the Biology of Cytoskeleton, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Neuropathol Exp Neurol 67:341-54. 2008
    ..Our results indicate that in the midgestational human brain, betaIII-tubulin is not neuron specific because it is constitutively expressed in GFAP+/nestin+ presumptive fetal astrocytes...
  36. doi Histochemical and immunohistochemical study in melasma: evidence of damage in the basal membrane
    Bertha Torres-Alvarez
    Department of Dermatology, Hospital Central Dr Ignacio Morones Prieto, Universidad Autonoma de San Luis Potosi, S L P, UASLP, Mexico
    Am J Dermatopathol 33:291-5. 2011
    ..We were surprised by the unexpected evidence of damage to basal membrane (BM), which could facilitate the fall or the migration of active melanocytes and melanin into the dermis allowing the constant hyperpigmentation in melasma...
  37. ncbi Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum
    K L Schreiber
    Department of Immunology, Mayo Clinic, Rochester, MN 55905
    Int Immunol 6:101-11. 1994
    ..The isolation of cDNA fragments encoding murine calnexin will allow us to further evaluate the functional consequences of calnexin-class II interaction...
  38. doi Emergence of highly neurofilament-immunoreactive zipper-like axon segments at the transection site in scalpel-cordotomized adult rats
    T Nishio
    Department of Integrative Brain Science, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto, Japan
    Neuroscience 155:90-103. 2008
    ..New York: Hafner]. On the other hand, axonal regenerative responses start within 6 h of injury, which may be supported by calpain-activation and intra-axonal protein synthesis...
  39. pmc Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay
    R Sargur
    Department of Immunology, Northern General Hospital, Sheffield, UK
    Clin Exp Immunol 163:339-45. 2011
    ..False positive MCT levels can be caused by rheumatoid factor. We suggest a strategy for identifying assay interference, and show that it is essential to incorporate this caveat into guidance for interpretation of MCT results...
  40. ncbi [Study of the mechanism of mast cell increase in cellular leiomyoma of uterus]
    Jie Qiang Lu
    Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China
    Zhonghua Fu Chan Ke Za Zhi 42:390-3. 2007
    ..To study the mechanism of mast cell increase in cellular leiomyoma of uterus...
  41. ncbi Trehalose accumulation in mutants of Saccharomyces cerevisiae deleted in the UDPG-dependent trehalose synthase-phosphatase complex
    J C Ferreira
    Departamento de Bioquimica, Instituto de Quimica, Universidade Federaldo Rio de Janeiro, Brazil
    Biochim Biophys Acta 1335:40-50. 1997
    ..synthase encoded by the GGS1/TPS1 (= FDP1, = BYP1, = CIF1) gene, trehalose 6-phosphatase encoded by the TPS2 gene and by a third protein encoded by both the TSL1 and TPS3 genes...
  42. ncbi Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries
    L D Longo
    Center for Perinatal Biology, Departments of Physiology, Pharmacology and Obstetrics and Gynecology, Loma Linda University, School of Medicine, Loma Linda, California 92350, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1419-29. 2000
    ..The mechanisms differ in the two age groups, however, and this probably relates, in part, to the relative lack of PKC-epsilon in fetal vessels...
  43. pmc Modulation of endogenous beta-tubulin isotype expression as a result of human beta(III)cDNA transfection into prostate carcinoma cells
    S Ranganathan
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Br J Cancer 85:735-40. 2001
    ..These results highlight the difficulty in isolating the contribution of single tubulin isotypes in drug response studies...
  44. ncbi Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis
    Shunji Nakano
    Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, and Department of Internal Medicine, Hakuai Kinen Hospital, Tokushima, 770 8503, Japan
    Clin Rheumatol 26:1284-92. 2007
    ..Mast cell tryptase in synovial fluid stimulates the proliferation of SFCs and the release of pro-inflammatory cytokines via PAR-2, which may contribute to exacerbation of synovitis in RA...
  45. doi Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans
    María Martínez-Esparza
    Departamento de Bioquímica y Biología Molecular B e Inmunología, Facultad de Medicina, Universidad de Murcia, E 30100 Murcia, Spain
    Int J Med Microbiol 299:453-64. 2009
    Disruption of the TPS2 gene encoding the only trehalose-6P phosphatase activity in Candida albicans caused a pleiotropic defective phenotype, maintaining the cell wall integrity and the ability to form chlamydospores...
  46. ncbi The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis
    M K Lee
    Neuroscience Program, University of Virginia, Charlottesville
    Cell Motil Cytoskeleton 17:118-32. 1990
    ..This localization pattern indicates that c beta 4 expression occurs either during or immediately following terminal mitosis, and suggests that beta III may have a unique role during early neuronal differentiation and neurite outgrowth...
  47. ncbi Beta-actinin is equivalent to Cap Z protein
    K Maruyama
    Department of Molecular Biology, Psychiatric Research Institute of Tokyo, Japan
    J Biol Chem 265:8712-5. 1990
    ..Thus it is concluded that highly purified beta-actinin is identical with the more recently described Cap Z, an actin barbed-end capping protein of chicken skeletal muscle...
  48. ncbi Characterization of two distinct DR beta chain alleles at the beta III locus of the DR5 haplotype: beta III alleles are highly conserved
    D K Didier
    J Immunol 137:2627-31. 1986
    ....
  49. ncbi Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
    D E Jenne
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunol Rev 103:53-71. 1988
    ..The strictly regulated secretion of granzymes and the lack of measurable enzymatic activity in the case of granzymes B, C, E and F towards a variety of synthetic substrates suggest a highly specific function for each of them...
  50. ncbi Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein)
    T Sato
    Section on Metabolic Regulation, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:10314-22. 1995
    ..A near homogeneous 20-kDa DNA-binding protein purified from rat brain was able to bind to these AT-rich regions of both Ng/RC3 and PKC-gamma genes with footprints containing ATTA, ATAA, and AATA sequences...
  51. ncbi Phosphorylation of beta III-tubulin
    I A Khan
    Department of Biochemistry, The University of Texas Health Science Center, San Antoxio, Texas 78284 7760, USA
    Biochemistry 35:3704-11. 1996
    ..Our results suggest the possibility that beta III phosphorylation may play a role in regulating microtubule assembly in vivo...
  52. ncbi Protein kinase C beta II isoform is up-regulated in human proliferative glomerulonephritis
    M B Ganz
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Exp Nephrol 5:225-32. 1997
    ..The consistent expression of PKC beta II in proliferative GN suggests a key signaling role for this enzyme in cell proliferation in renal disease...
  53. ncbi Expression of mast cell proteases in rat lung during helminth infection: mast cells express both rat mast cell protease II and tryptase in helminth infected lung
    M Tomita
    Department of Parasitology, Miyazaki Medical College, Kiyotake, Miyazaki, Japan
    Int Arch Allergy Immunol 120:303-9. 1999
    ..However, a previous study of ours showed that the expression of rat mast cell tryptase (RMCT) mRNA, which has been reported to be confined to CTMC, significantly increased in rat lung 14 days after infection...
  54. ncbi Loose ligation of the rat sciatic nerve is accompanied by changes in the subcellular content of protein kinase C beta II and gamma in the spinal dorsal horn
    V Miletic
    Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706 1102, USA
    Neurosci Lett 288:199-202. 2000
    ..These data support suggestions that peripheral nerve injury engenders plastic changes in the dorsal horn to contribute to the development of persistent pain...
  55. ncbi Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors
    J M Dener
    Department of Medicinal Chemistry, Axys Pharmaceuticals, Inc 180 Kimball Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 11:2325-30. 2001
    ..Using two classes of analogues as lead structures, several monocharged derivatives were identified with K(i) values ranging from 0.084 to 0.21 microM against the enzyme...
  56. ncbi Combination of gonadal steroid treatment and peripheral nerve grafting results in a peripheral motoneuron-like pattern of beta II-tubulin mRNA expression in axotomized hamster rubrospinal motoneurons
    Paul D Storer
    Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, IL 60153, USA
    J Comp Neurol 449:364-73. 2002
    ..The synergistic effects of the two treatment strategies confirm the importance of targeting multiple aspects of the injury response for therapeutic intervention...
  57. ncbi Protein kinase C beta (PKC beta): normal functions and diseases
    Toshiaki Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, Science Center Drive, San Diego, California 92121, USA
    J Biochem 132:677-82. 2002
    ..Their involvement in disorders due to pertubations in these signaling systems, i.e., immunodeficiencies and diabetes, is also reviewed. Finally, patterns of PKC action in these and other biologic systems are discussed...
  58. ncbi Mast cell density, neuronal hypertrophy and nerve growth factor expression in patients with acute appendicitis
    Nigar Coskun
    Department of Anatomy, Akdeniz University, Medical School, Antalya, Turkey
    Folia Morphol (Warsz) 61:237-43. 2002
    ....
  59. ncbi PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current
    Guang Qian Xiao
    Molecular and Cellular Cardiology Program, SUNY Downstate Medical Center, Research and Development Office 151, VA New York Harbor Healthcare System, 800 Poly Place, Brooklyn, NY 11209, USA
    Biochem Biophys Res Commun 306:1019-25. 2003
    ..Identification of the particular isozyme(s) that mediates the regulation of I(Ks) channels is of importance for the understanding of the mechanism of ion channel regulation and the development of new therapeutic agents...
  60. ncbi Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells
    Marianne Høy
    Laboratory of Islet Cell Physiology, Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    J Biol Chem 278:35168-71. 2003
    ..These data demonstrate that PKC-epsilon is involved in InsP6-induced exocytosis in pancreatic beta-cells...
  61. ncbi Analysis of solution nonideality of a pseudomorphic drug system through a comprehensive thermodynamic framework for the design of a crystallization process
    Fredrik L Nordstrom
    Department of Chemical Engineering and Technology, Royal Institute of Technology, 10044 Stockholm, Sweden
    J Pharm Sci 93:995-1004. 2004
    ..The resulting explanation has major consequences for crystallization process development...
  62. ncbi Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice
    Wouter J de Jonge
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 127:535-45. 2004
    ..Here, we evaluate the role of mast cell activation in the recruitment of infiltrates in a murine model...
  63. ncbi Subset of cells immunopositive for neurokinin-1 receptor identified as arterial interstitial cells of Cajal in human large arteries
    Yuri V Bobryshev
    Surgical Professorial Unit Level 5, St Vincent s Hospital, DeLacy Building, Darlinghurst, NSW, 2010, Australia
    Cell Tissue Res 321:45-55. 2005
    ..The functional significance of the arterial interstitial cells of Cajal and their possible involvement in atherosclerosis and other vascular diseases need clarification...
  64. ncbi Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins
    Claire Jacob
    Department of Surgery, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:31936-48. 2005
    ..These mechanisms may explain the increased epithelial permeability of the intestine during stress and inflammation...
  65. pmc GABAergic lineage differentiation of AF5 neural progenitor cells in vitro
    Joseph F Sanchez
    Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Cell Tissue Res 324:1-8. 2006
    ..Therefore, AF5 cells can be induced to differentiate to a neuronal phenotype with a GABAergic lineage...
  66. ncbi Spectrin mutations cause spinocerebellar ataxia type 5
    Yoshio Ikeda
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 321 Church St SE, Minneapolis, Minnesota 55455 USA
    Nat Genet 38:184-90. 2006
    ..Spectrin mutations are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling...
  67. ncbi Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea
    Shriram Jakate
    Department of Pathology, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Pathol Lab Med 130:362-7. 2006
    ..In some adult patients with chronic intractable diarrhea, the diagnosis remains elusive even after detailed evaluations, and colonic or duodenal biopsy specimens may appear unremarkable on routine hematoxylin-eosin staining...
  68. ncbi Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B
    Bjorn Lindkvist
    Department of Surgery, Malmo University Hospital, Lund University, Malmo, Sweden
    Pancreatology 6:224-31. 2006
    ..The aim of this study was to investigate cathepsin B and tryptase activation of pancreatic zymogens...
  69. ncbi Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
    Yoshikazu Yoshino
    Department of Neurosurgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Int J Oncol 29:981-7. 2006
    ....
  70. ncbi Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients
    Henry Klassen
    Stem Cell Research, Children s Hospital of Orange County, Orange, California, USA
    Stem Cells 25:1222-30. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  71. ncbi Elastofibroma: a clinicopathologic and immunohistochemical study of seven cases and literature review
    Banu Dogan Gun
    Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
    APMIS 115:115-9. 2007
    ..Collagen type IV immunoreactivity was seen in two cases. No staining was observed with smooth muscle actin, desmin or S-100 protein. Our findings suggest that CD34-positive mesenchymal cells are an integral component of elastofibroma...
  72. ncbi Beneficial impact of L-carnitine in liver: a study in a rat model of syndrome X
    P Rajasekar
    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    Amino Acids 35:475-83. 2008
    ..In summary the data suggest that elevated oxidative damage and PKC expression could in part induce insulin resistance and CA has beneficial impact on liver during insulin resistance with modulatory effects at the post-receptor level...
  73. doi Intravitreal colchicine causes decreased RNFL birefringence without altering RNFL thickness
    Brad Fortune
    Devers Eye Institute, Legacy Health System, 1225 NE Second Avenue, Portland, OR 97232, USA
    Invest Ophthalmol Vis Sci 49:255-61. 2008
    ....
  74. doi Late-phase allergic reaction in nasal provocation with fungal allergens
    Marek Niedoszytko
    Department of Allergology, Medical University of Gdansk, Gdansk, Poland
    Allergy Asthma Proc 29:35-9. 2008
    ..001). The nasal allergen challenge with fungal allergen seems to be a promising diagnostic method of allergic rhinitis. Late phase of the allergic reaction seems to be an important part of the assessment...
  75. doi Gene expression profiles and intracellular contents of stress protectants in Saccharomyces cerevisiae under ethanol and sorbitol stresses
    Tomohiro Kaino
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0192, Japan
    Appl Microbiol Biotechnol 79:273-83. 2008
    ..In contrast, in the presence of 9% ethanol, the rapid induction of TPS2 encoding trehalose-6-phosphate phosphatase resulted in trehalose accumulation...
  76. doi Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer
    Karen Lise Garm Spindler
    Danish Colorectal Cancer Group South, Vejle Hospital, 7100, Vejle, Denmark
    Int J Colorectal Dis 24:641-5. 2009
    ..Little is known about the expression of PKC-beta in colorectal cancer or the prognostic value in colorectal cancer, which was the focus of the present study...
  77. doi Neural stem/progenitor cells differentiate in vitro to neurons by the combined action of dibutyryl cAMP and interferon-gamma
    Tasneem Zahir
    Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Stem Cells Dev 18:1423-32. 2009
    ..These NSPC-derived neurons may be promising for neural regenerative strategies in the CNS...
  78. doi Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in experimental autoimmune encephalomyelitis
    Rina Aharoni
    The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Neuroimmunol 215:73-83. 2009
    ..The therapeutic potential of myogenic progenitor cells was demonstrated by amelioration of clinical symptoms and reduced mortality in EAE mice, as well as by expression of IL-10, TGF-beta, and the neurotrophin-BDNF...
  79. pmc A comparative study of the spatial distribution of mast cells and microvessels in the foetal, adult human thymus and thymoma
    Marius Raica
    Department of Histology and Cytology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
    Int J Exp Pathol 91:17-23. 2010
    ..This could be an expression of their involvement not only in endothelial cells but also in tumour cell proliferation...
  80. doi Taurine stimulates proliferation of mice embryonic cultured neural progenitor cells
    Reyna Hernández-Benítez
    Division de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Neurosci Res 88:1673-81. 2010
    ..These results point to taurine as a trophic factor contributing to optimize NPC proliferation...
  81. doi Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation
    Pohsheng Yeong
    Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, 138 Yixueyuan Road, Shanghai 200032, China
    Biochim Biophys Acta 1801:567-76. 2010
    ..This investigation sheds a new light on the role of tryptase in foam cell formation and pathogenesis of atherosclerosis...
  82. doi Fetuin-a in the developing brain
    Johannes Elsas
    Department of Pediatrics, University Hospital, RWTH Aachen, Aachen, Germany
    Dev Neurobiol 73:354-69. 2013
    ..Further research on the role of fetuin-A in the neonatal brain during physiological and pathological conditions is recommended...
  83. ncbi Tryptase in diagnosing adverse suspected anaphylactic reaction
    Grazyna Michalska-Krzanowska
    Division of Anesthesiology and Intensive Care, 111th Military Hospital with Outpatient Clinic, Poznan, Poland
    Adv Clin Exp Med 21:403-8. 2012
    ..Patients with normal tryptase concentration should also undergo further diagnosis if they manifest clinical symptoms of a severe anaphylactic reaction...
  84. doi Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome
    Ewa M Wilcz-Villega
    Department of Clinical Medicine, Adelaide and Meath Hospital, Dublin, Ireland
    Am J Gastroenterol 108:1140-51. 2013
    ..The objective of this study was to investigate how mast cell tryptase may influence intestinal permeability and tight junction (TJ) proteins in vitro and explore translation to irritable bowel syndrome (IBS)...
  85. pmc Allosteric control of βII-tryptase by a redox active disulfide bond
    Kristina M Cook
    From the Lowy Cancer Research Centre and Prince of Wales Clinical School and
    J Biol Chem 288:34920-9. 2013
    ..These observations indicate that βII-tryptase activity is post-translationally regulated by an allosteric disulfide bond. It is likely that other S1A serine proteases are similarly regulated. ..
  86. pmc Characterization of two homogalacturonan pectins with immunomodulatory activity from green tea
    Huijun Wang
    The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
    Int J Mol Sci 15:9963-78. 2014
    ..The crude tea polysaccharides (TPS1 and TPS2) were obtained from green tea leaves by hot water extraction and followed by 40% and 70% ethanol precipitation, ..
  87. ncbi Does bile protect or damage interstitial Cajal-like cells in the human gallbladder?
    Artur Pasternak
    First Chair of General, Oncological and Gastrointestinal Surgery, Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland
    Folia Med Cracov 53:47-59. 2013
    ..The results suggest that bile composition may play an important role in the reduction of ICLC density in the gallbladder. ..
  88. doi Human beta-defensin-3 producing cells in septic implant loosening
    Jaakko Levon
    Department of Anatomy, Institute of Biomedicine, BMH 1, PO Box 63, 00014, Helsinki, Finland
    J Mater Sci Mater Med 26:98. 2015
    ..The results explain the increased synovial fluid/tissue concentrations of hBD-3 in septic loosening. ..
  89. doi Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease
    Michael J Hurley
    Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    J Mol Neurosci 57:48-62. 2015
    ..Given the role of PAR2 in neuroinflammation, drugs that mitigate these changes may be neuroprotective when administered to patients with Parkinson's disease. ..
  90. doi Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats
    Takeshi Tanaka
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu shi, Tokyo 183 8509, Japan Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 1 1 Yanagido, Gifu shi, Gifu 501 1193, Japan Electronic address
    Toxicology 336:59-69. 2015
    ..The no-observed-adverse-effect level for offspring neurogenesis was determined to be 0.1 ppm (7.1-13.6 mg/kg body weight/day)...
  91. doi The stem cell growth factor receptor KIT is not expressed on interstitial cells in bladder
    Thomas Gevaert
    Laboratory of Experimental Urology, Organ Systems, KU Leuven, Leuven, Belgium
    J Cell Mol Med . 2016
    ..In this perspective, functional concepts of KIT+ ICC being involved in sensory and/or motor aspects of bladder physiology should be revised...
  92. pmc Role of mast cell-miR-490-5p in irritable bowel syndrome
    Hai xia Ren
    Hai Xia Ren, He Sheng Luo, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
    World J Gastroenterol 23:93-102. 2017
    ..To determine the functional role of miR-490-5p in mast cell proliferation and apoptosis, and in the mast cell tryptase/PAR-2 signal pathway...
  93. ncbi Human mouse mast cell protease 7-like tryptase genes are pseudogenes
    H K Min
    Department of Internal Medicine, Virginia Commonwealth University, Richmond 23298, USA
    J Allergy Clin Immunol 107:315-21. 2001
    ..A third family of tryptase genes on human chromosome 16 has been identified and called human mouse mast cell protease 7 (hmMCP-7)-like tryptase...
  94. ncbi Trehalose metabolism in Arabidopsis: occurrence of trehalose and molecular cloning and characterization of trehalose-6-phosphate synthase homologues
    G Vogel
    Botanisches Institut, Universitat Basel, Hebelstrasse 1, CH 4056 Basel, Switzerland
    J Exp Bot 52:1817-26. 2001
    ..cerevisiae tps2 mutant lacking TPP activity...
  95. ncbi LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis
    Peter A Edwards
    Departments of Biological Chemistry and Medicine, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Vascul Pharmacol 38:249-56. 2002
    ..In this review, we summarize the current status of this rapidly moving area with a special emphasis on the potential for pharmacological intervention...
  96. ncbi Chlorine inhalation produces nasal congestion in allergic rhinitics without mast cell degranulation
    D Shusterman
    Dept of Medicine, University of California, San Francisco, CA, USA
    Eur Respir J 21:652-7. 2003
    ..However, unlike nasal allergen challenge, the mechanism of response to chlorine does not appear to involve mast cell degranulation...
  97. ncbi Mast cell inhibitor cromolyn increases blood clotting and hypoxia in murine breast cancer
    Michael Samoszuk
    Pathology Department, University of California, Irvine, Orange, CA 92868, USA
    Int J Cancer 107:159-63. 2003
    ..We conclude that sodium cromolyn enhanced peri-tumoral blood clotting and intratumoral hypoxia. These results suggest that mast cells may play an important role in regulating blood clotting and hypoxia within breast cancer...
  98. ncbi Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells
    Y K Jang
    Brain Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    J Neurosci Res 75:573-84. 2004
    ..These results indicate that human cord blood-derived CD133+ hematopoietic stem cells could trans-differentiate into neural cell types of neuron-like cells, astrocytes, and oligodendrocytes by RA treatment...
  99. ncbi Mast cell tryptase in postmortem serum-reference values and confounders
    Erik Edston
    Institution for Clinical and Molecular Medicine, Linkoping University, Linköping 581 85, Sweden
    Int J Legal Med 121:275-80. 2007
    ..It is concluded that asphyxia premortem seems to affect tryptase concentrations, that postmortem tryptase measurements should be done in serum from femoral blood, and that the normal upper limit, covering 95%, is 44.3 microg/l...
  100. ncbi Structure-function analysis of mouse Pur beta II. Conformation altering mutations disrupt single-stranded DNA and protein interactions crucial to smooth muscle alpha-actin gene repression
    Anna M Knapp
    Departments of Biochemistry and Medicine, Cardiovascular Research Institute, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 282:35899-909. 2007
    ....
  101. pmc Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
    Neil N Trivedi
    Cardiovascular Research Institute, University of California at San Francisco, San Francisco, Calif, USA
    J Allergy Clin Immunol 124:1099-105.e1-4. 2009
    ..Tryptase gene loci TPSAB1 and TPSB2 are known to be polymorphic, but the nature and extent of diversity at these loci have not been fully explored.

Research Grants55

  1. Praveen Thumbikat; Fiscal Year: 2016
    ..Finally, this project will test the efficacy of new therapies targeting chronic pelvic pain in animal models. ..
  2. Matthew J Hamilton; Fiscal Year: 2016
    ..In this environment and with the guidance of my mentors and collaborators, I will be poised to attain my goal of becoming an independent investigator. ..
  3. The effect of pathological mutations in beta-III tubulin on microtubules and axon
    ADRIANNE LYNN KOLPAK; Fiscal Year: 2012
    ....
  4. RECOMBINANT HUMAN MAST CELL TRYPTASES
    David Johnson; Fiscal Year: 2000
    ....
  5. MECHANISM OF HUMAN MAST CELL TRYPTASE REGULATION
    Norman Schechter; Fiscal Year: 2003
    ..Understanding the structural properties responsible for the functional instability may provide new targets for therapeutic inhibitors. ..
  6. Kalpna Gupta; Fiscal Year: 2016
    ..We expect that the multidisciplinary approach combining biochemistry, neurophysiology, pharmacology, behavior and biomedical engineering will advance the treatment of pain in SCD. (End of Abstract) ..
  7. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 2002
    ....
  8. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
    ..abstract_text> ..
  9. MOLECULAR PATHOGENESIS OF RADIATION ENTEROPATHY
    Martin Hauer Jensen; Fiscal Year: 2005
    ..This project may facilitate development of specific strategies to minimize intestinal radiation toxicity, thereby making radiation therapy safer and more effective. ..
  10. PAR2, Bronchopulmonary Sensory Nerve and Pathogenesis of Asthma
    Qihai Gu; Fiscal Year: 2009
    ..The proposed project will investigate how activation of this receptor regulates the pulmonary sensory nerve responses to low pH in the airways, and how these interactions will affect the disease process of asthma. ..
  11. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2005
    ....
  12. BIOCHEMISTRY OF MAST CELL SECRETORY GRANULE ENZYMES
    Lawrence Schwartz; Fiscal Year: 2000
    ..abstract_text> ..
  13. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  14. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ....
  15. MECHANISMS AND MODULATION OF VISCERAL PAIN
    Gerald Gebhart; Fiscal Year: 2009
    ..g., ATP, mast cell tryptase, serotonin) contribute to visceral hypersensitivity and can do so in the absence of frank tissue damage, which is relevant to IBS and other functional gastrointestinal disorders. ..
  16. EFFECTS OF O3 AND NO2 ON HUMAN LUNG PROTEINS
    David Johnson; Fiscal Year: 1992
    ..Knowledge will be gained on the molecular and cellular reactions of O3 and NO2, which could lead to better markers of oxidant exposure and eventually to methods of intervention or protection from the adverse effects of O3 and NO2...
  17. Topographic Spectrin Assembly in the Renal Tubule Cell
    Jon Morrow; Fiscal Year: 2007
    ..abstract_text> ..
  18. VP-16/BRYOSTATIN 1 FOR TREATMENT OF RESISTANT LEUKEMIA
    Jack Yalowich; Fiscal Year: 1999
    ....
  19. Retinal Oxygenation in Diabetic Retinopathy
    BRUCE BERKOWITZ; Fiscal Year: 2004
    ..The results of these studies could lead to the development of a non-invasive real time method for the early evaluation of diabetic retinopathy and its treatment. ..
  20. Cloning a Membrane Estrogen Receptor in Developing Brain
    Dominique Toran Allerand; Fiscal Year: 2003
    ..abstract_text> ..
  21. THE ROLE OF CTGF IN SUBEPITHELIAL FIBROSIS IN ASTHMA
    DAVID RISHIKOF; Fiscal Year: 2004
    ..This award will prepare the investigator for an independent research career. ..
  22. Chemoprevention of colitis-associated colon cancer
    E Thompson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. CELL KILLING BY TOPOISOMERASE ACTIVE ANTICANCER DRUGS
    James Wang; Fiscal Year: 2000
    ..The DNA topoisomerases are unique in that they are not only targets in the treatment of cancer, they may also play key roles in oncogenesis. The proposed studies may thus contribute to both cancer treatment and prevention. ..
  24. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  25. PKC Beta II: A target for colon cancer chemoprevention
    Nicole Murray; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  26. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    CHRISTINA DANIELS; Fiscal Year: 2007
    ..Cell signaling pathway(s) responsible for protection from apoptosis will be identified by determining the specific sites of serine phosphorylation of the propapoptotic protein BAD. ..
  27. Effects of Ang II and hypoxia on the blood-brain barrier
    MELISSA FLEEGAL DEMOTTA; Fiscal Year: 2006
    ..The goal is to investigate the effects of Ang II and hypoxia on PKC(alpha, beta-I, beta-II, gamma) expression and activity and its effects on tight junctions and BBB permeability. ..
  28. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  29. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  30. Activation of the human neurtrophil
    HELEN KORCHAK; Fiscal Year: 2005
    ..V Establish the role of d-PKC in downregulation of signalling pathways triggered by the p60TNFR. Determine if d-PKC acts on a serine residue(s) in the juxtamembrane region or the death domain. ..
  31. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  32. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..abstract_text> ..
  33. STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENT
    Maya Sieber Blum; Fiscal Year: 2003
    ..However, the newly detected additional roles of SCF in maintaining stem cells, up-regulating neurotrophin receptors and promoting sensory neurogenesis suggest additional defects in human piebaldism that remain to be elucidated. ..
  34. Regulation of Protein Kinase C Translocation
    JOSEPH O FLAHERTY; Fiscal Year: 2005
    ..abstract_text> ..
  35. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  36. PROTEIN TYROSINE KINASES AND MAST CELL ACTIVATION
    Toshiaki Kawakami; Fiscal Year: 2001
    ..Particularly, interactions of Btk with Src PTKs and ERK might suggest positive and negative, respectively, feedback mechanisms for FceRI induced mast cell activation. ..
  37. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  38. Mast cell regulation by PKC and Akt
    Toshiaki Kawakami; Fiscal Year: 2005
    ..Given the critical importance of PKC in degranulation and other activation events, these studies are also likely to provide an opportunity for novel therapeutic modalities aimed at allergic diseases. ..
  39. TH and GTPCHI gene therapy for Parkinson's disease
    Jeffrey H Kordower; Fiscal Year: 2010
    ..These studies will determine the safety and efficacy of gene delivery of LDOPA and determine whether this approach is appropriate for clinical trials. ..
  40. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  41. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2002
    ..abstract_text> ..
  42. PROTEIN KINASE C IN ISCHEMIC RENAL INJURY AND REPAIR
    Babu Padanilam; Fiscal Year: 2002
    ..These observations will be extended to test the effects of various PKC activators and inhibitors on renal function, morphology, cell proliferation, apoptosis and differentiation post- ischemia. ..
  43. Identification of Genes Activated by Bile Acids
    Peter Edwards; Fiscal Year: 2009
    ..In addition, these studies will elucidate the role of FXR in glucose, steroid and drug metabolism and in resistance to endotoxin. ..
  44. DYSKINESIAS IN LENTI-GDNF TREATED PARKINSONIAN MONKEYS
    Jeffrey Kordower; Fiscal Year: 2006
    ..This application will determine whether potent dopaminergic gene therapies influence dyskinesias in the best animal model of PD. ..
  45. Regulation of asthma by Btk and family kinases
    Toshiaki Kawakami; Fiscal Year: 2008
    ..This is a poorly explored area in DC biology. Our efforts will hopefully identify novel targets for pharmaceutical intervention to treat asthma and other immune diseases. ..
  46. Mechanisms of Ataxin-1 Mediated Purkinje Cell Death
    PARMINDER VIG; Fiscal Year: 2007
    ..Further, changes observed in SCA-1 patients and in transgenic mice will be compared with that in Machado-Joseph disease/SCA-3, other cerebellar ataxias and normal controls. ..
  47. MECHANISMS OF SYMPATHETIC NEURON SPECIFICATION
    Maya Sieber Blum; Fiscal Year: 2004
    ..Both types of drug easily cross the placenta and can cause autonomic disturbances in infants born to mothers who have been treated with the antidepressant, or who have used cocaine during pregnancy. ..
  48. Cocaine and Apoptosis in the Developing Heart
    Lubo Zhang; Fiscal Year: 2004
    ..Such an understanding has obvious clinical implications because the increasing information has pointed to an important role of apoptosis in cardiovascular diseases. ..
  49. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  50. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  51. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  52. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005
    ..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
  53. IgE Regulation of Mast Cell Growth and Survival
    Toshiaki Kawakami; Fiscal Year: 2006
    ..abstract_text> ..