TOX3

Summary

Gene Symbol: TOX3
Description: TOX high mobility group box family member 3
Alias: CAGF9, TNRC9, TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, trinucleotide repeat-containing gene 9 protein
Species: human

Top Publications

  1. doi A combined analysis of genome-wide association studies in breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177 Stockholm, Sweden
    Breast Cancer Res Treat 126:717-27. 2011
  2. doi Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany
    Int J Cancer 126:2858-62. 2010
  3. doi Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population
    Jie Liang
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, 210029 Nanjing, China
    Breast Cancer Res Treat 124:237-41. 2010
  4. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
  5. pmc Fine scale mapping of the breast cancer 16q12 locus
    Miriam S Udler
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Hum Mol Genet 19:2507-15. 2010
  6. pmc Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Department of Epidemiology, School of Public Health, 1010 Commonwealth Avenue, Boston MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 19:1320-7. 2010
  7. pmc Genome-wide association study identifies five new breast cancer susceptibility loci
    Clare Turnbull
    Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:504-7. 2010
  8. pmc Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Genet 6:e1001002. 2010
  9. doi Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci
    Gillian K Reeves
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    JAMA 304:426-34. 2010
  10. doi Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects
    Min Bin Chen
    Department of Oncology, Kunshan People s Hospital Affiliated To Jiangsu University, Kunshan, 215300, Jiangsu, China
    Breast Cancer Res Treat 126:177-83. 2011

Research Grants

  1. A Follow-up Study for Causes of Illness in Black Women
    Lynn Rosenberg; Fiscal Year: 2013
  2. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006
  3. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  4. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  5. P21 INDUCTION BY BRCA2
    Fergus Couch; Fiscal Year: 2002
  6. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
  7. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006
  8. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2007
  9. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
  10. Vitamin D and Mammographic Density
    Rulla Tamimi; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications86

  1. doi A combined analysis of genome-wide association studies in breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177 Stockholm, Sweden
    Breast Cancer Res Treat 126:717-27. 2011
    ..More effort focused in these aspects of oncology can potentially open up promising avenues for the understanding of breast cancer and its prevention...
  2. doi Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany
    Int J Cancer 126:2858-62. 2010
    ..43, 95% CI 1.30-1.59, p-value = 1.24 x 10(-12)) and for TNRC9 (OR = 1.33, 95% CI 1.19-1.46, p-value = 1.54 x 10(-7))...
  3. doi Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population
    Jie Liang
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, 210029 Nanjing, China
    Breast Cancer Res Treat 124:237-41. 2010
    Trinucleotide repeat-containing 9 (TNRC9), a high mobility group chromatin-associated protein, has been implicated in breast cancer metastasis to the bone...
  4. pmc Performance of common genetic variants in breast-cancer risk models
    Sholom Wacholder
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
    N Engl J Med 362:986-93. 2010
    ..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
  5. pmc Fine scale mapping of the breast cancer 16q12 locus
    Miriam S Udler
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Hum Mol Genet 19:2507-15. 2010
    ..containing the largely uncharacterized hypothetical gene LOC643714, a short intergenic region and the 5' end of TOX3. Re-sequencing this segment in European subjects identified 293 common polymorphisms, including a set of 26 highly ..
  6. pmc Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women
    Edward A Ruiz-Narváez
    Slone Epidemiology Center at Boston University, Department of Epidemiology, School of Public Health, 1010 Commonwealth Avenue, Boston MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 19:1320-7. 2010
    The rs3803662 single nucleotide polymorphism (SNP) in the TOX3/LOC643714 region was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry and has been ..
  7. pmc Genome-wide association study identifies five new breast cancer susceptibility loci
    Clare Turnbull
    Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:504-7. 2010
    ....
  8. pmc Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium
    Jirong Long
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Genet 6:e1001002. 2010
    ..1 and demonstrate the utility of conducting genetic association studies in populations with different genetic architectures...
  9. doi Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci
    Gillian K Reeves
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    JAMA 304:426-34. 2010
    ..There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination...
  10. doi Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects
    Min Bin Chen
    Department of Oncology, Kunshan People s Hospital Affiliated To Jiangsu University, Kunshan, 215300, Jiangsu, China
    Breast Cancer Res Treat 126:177-83. 2011
    Trinucleotide repeat containing 9 (TNRC9) is a gene located at chromosome 16q12. Although of an uncertain function, it is a newly described risk factor for breast cancer...
  11. pmc TOX defines a conserved subfamily of HMG-box proteins
    Emmett O'Flaherty
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA92037, USA
    BMC Genomics 4:13. 2003
    ..We recently identified an HMG-box protein involved in T cell development, designated TOX, which is highly conserved in humans and mice...
  12. doi TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex
    Sonja Dittmer
    Department of Neurology, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    J Cell Sci 124:252-60. 2011
    b>TOX3 is a nuclear protein containing a high mobility group (HMG)-box domain, which regulates Ca(2+)-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB)...
  13. doi Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  14. pmc Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1
    Juliane Winkelmann
    Institute of Human Genetics, Technische Universitat Munchen, Munich, Germany
    PLoS Genet 7:e1002171. 2011
    ..03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767.
  15. pmc Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression
    Richard Cowper-Sal Lari
    Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Nat Genet 44:1191-8. 2012
    ..SNPs modulate the affinity of chromatin for FOXA1 at distal regulatory elements, thereby resulting in allele-specific gene expression, which is exemplified by the effect of the rs4784227 SNP on the TOX3 gene within the 16q12.1 risk locus.
  16. pmc The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients
    Eydis Th Gudmundsdottir
    Department of Pathology, Landspitali University Hospital, Hringbraut, 101, Reykjavik, Iceland
    BMC Cancer 12:621. 2012
    ..allele of SNP rs3803662 has been shown to correlate with increased breast cancer risk and with lower expression of TOX3. The SNP is closely located to TOX3 residing within an uncharacterised gene LOC643714...
  17. doi TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness
    Jingxuan Shan
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar Qatar Foundation, Qatar
    Cancer Res 73:2840-9. 2013
    ..The breast cancer gene trinucleotide-repeat-containing 9 (TNRC9; TOX3) has been associated with disease susceptibility but its function is undetermined...
  18. pmc Genome-wide association studies identify four ER negative-specific breast cancer risk loci
    Montserrat Garcia-Closas
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK 3
    Nat Genet 45:392-8, 398e1-2. 2013
    ..0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers...
  19. pmc TOX3 mutations in breast cancer
    James Owain Jones
    Cambridge Research Institute, Cancer Research UK, Cambridge, United Kingdom
    PLoS ONE 8:e74102. 2013
    b>TOX3 maps to 16q12, a region commonly lost in breast cancers and recently implicated in the risk of developing breast cancer. However, not much is known of the role of TOX3 itself in breast cancer biology...
  20. pmc Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China
    Xuanqiu He
    The First Clinical College, Southern Medical University, Guangzhou 510515, China
    Int J Mol Sci 15:2130-41. 2014
    ..risk is currently unclear, with contradictory evidence on the role of single nucleotide polymorphisms (SNPs) in TOX3/LOC643714 as a breast cancer susceptibility locus...
  21. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with ..
  22. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ..association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population...
  23. pmc Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    Petra E A Huijts
    Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Breast Cancer Res 9:R78. 2007
    ..Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer...
  24. ncbi Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer
    Simon N Stacey
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:865-9. 2007
    ..rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to ..
  25. pmc Evaluation of 11 breast cancer susceptibility loci in African-American women
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009
    ..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
  26. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0...
  27. pmc A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 41:579-84. 2009
    ..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
  28. ncbi cDNAs with long CAG trinucleotide repeats from human brain
    R L Margolis
    Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Genet 100:114-22. 1997
    ..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment...
  29. doi A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women
    F Chen
    Life Sciences school of Hubei University, Wuchang, Wuhan, China
    Genet Mol Res 13:182-7. 2014
    A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry...
  30. pmc Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function
    Rajesh Ramakrishnan
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    Retrovirology 9:90. 2012
    ..Nine CCAPs are novel, while three were previously identified as Core P-TEFb, the 7SK snRNP, and the Super-Elongation Complex. We have investigated the role of five newly identified CCAPs in Tat function and viral gene expression...
  31. pmc The relationship between eight GWAS-identified single-nucleotide polymorphisms and primary breast cancer outcomes
    Soley Bayraktar
    Department of Medical Oncology, Mercy Cancer Center, Ardmore, Oklahoma, USA
    Oncologist 18:493-500. 2013
    ..We investigated whether eight risk SNPs identified in GWAS were associated with breast cancer disease-free survival (DFS) and overall survival (OS) rates...
  32. doi Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
    Monique A de Bruin
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Fam Cancer 11:429-39. 2012
    ..01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002)...
  33. pmc Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25
    Laura Fejerman
    Division of General Internal Medicine, Department of Medicine, Institute of Human Genetics, University of California San Fancisco, San Francisco, California 94158, USA
    Nat Commun 5:5260. 2014
    ..These results highlight the importance of conducting research in diverse populations. ..
  34. pmc Phenotype and Tissue Expression as a Function of Genetic Risk in Polycystic Ovary Syndrome
    Cindy T Pau
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 12:e0168870. 2017
    ..The IRF1, SUMO1P1 and KRR1 loci may confer PCOS risk in development. The TOX3 and GATA4 loci appear to be involved in inflammation and its consequences...
  35. pmc Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells
    Dong Gui Hu
    Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Flinders Medical Centre, Adelaide 5042, Australia
    Int J Mol Sci 18:. 2016
    ..of prostate cancer (PCGEM1, PEG3, EPHA3, and EFNB2) or other types of human cancers (TOX3, ST8SIA4, and SLITRK3), and genes that are diagnostic/prognostic biomarkers of prostate cancer (<..
  36. doi Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studies
    Q Wang
    Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China
    Genet Mol Res 15:. 2016
    Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain...
  37. pmc The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population
    Chaowen Jiang
    Institute of Human Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
    Oncotarget 7:59742-59753. 2016
    ..to test our hypothesis that the previously identified breast cancer risk-associated genetic polymorphisms at the TOX3/LOC643714 locus might contribute to lung cancer risk, 16 SNPs at the TOX3/LOC643714 locus were evaluated in a Han ..
  38. doi TOX3 regulates neural progenitor identity
    Sanjeeb Kumar Sahu
    Institute of Molecular Biology, IMB, Mainz, Germany
    Biochim Biophys Acta 1859:833-40. 2016
    The human genomic locus for the transcription factor TOX3 has been implicated in susceptibility to restless legs syndrome and breast cancer in genome-wide association studies, but the physiological role of TOX3 remains largely unknown...
  39. pmc TOX3 protein expression is correlated with pathological characteristics in breast cancer
    Cui Cui Han
    Institute of Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang 161042, P R China
    Oncol Lett 11:1762-1768. 2016
    b>TOX3 is a newly identified gene that has been observed to correlate with breast cancer by genome-wide association studies (GWAS) in recent years...
  40. pmc TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk
    Ying Chen
    Department of Radiology, Shengjing Hospital Affiliated to China Medical University, No 36, Sanhao ST, Heping District, Shenyang, Liaoning Province, 110004, China
    World J Surg Oncol 14:50. 2016
    ..the association of fibroblast growth factor receptor 2 (FGFR2) rs2981582, trinucleotide-repeat-containing 9 (TNRC9) rs3803662, rs12443621, and leukocyte-specific protein 1 (LSP1) rs3817198 polymorphisms with breast cancer and ..
  41. doi Relationship between five GWAS-identified single nucleotide polymorphisms and female breast cancer in the Chinese Han population
    Yaning He
    Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University Henan Tumor Hospital, Zhengzhou, 450000, China
    Tumour Biol 37:9739-44. 2016
    ..Different genotypes of rs3803662 (TOX3)/ (TNRC9)) in the case group and the control group are statistically significant (P = 0...
  42. ncbi [Establishment of breast cancer MDA-MB-231 cell line stably over-expressing human TOX high mobility group box family member 3]
    Cuicui Han
    Basic Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:1154-8. 2014
    To construct the lentiviral expression vector of human TOX high mobility group box family member 3 (TOX3) gene and the MDA-MB-231 cell line which stably over-expresses TOX3 gene.
  43. doi Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population
    Isabel Elematore
    Human Genetics Program, Institute of Biomedical Sciences ICBM, School of Medicine, University of Chile, Av Independencia 1027, P O Box 70061, Santiago, Chile
    Mol Biol Rep 41:3715-22. 2014
    ..In the present study, we evaluated the association between rs3803662 (TOX3, also known as TNRC9), rs13387042 (2q35), and rs13281615 (8q24) with BC risk in 344 Chilean BRCA1/2-negative BC cases and in 801 ..
  44. doi A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population
    Aiko Sueta
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Breast Cancer Res Treat 132:711-21. 2012
    ..risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936...
  45. pmc The role of genetic breast cancer susceptibility variants as prognostic factors
    Peter A Fasching
    University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen Nuremberg, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Hum Mol Genet 21:3926-39. 2012
    ..CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC ..
  46. doi Breast cancer genome-wide association studies: there is strength in numbers
    D Fanale
    Department of Surgical and Oncological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
    Oncogene 31:2121-8. 2012
    ..GWAS) in BC revealed single nucleotide polymorphisms (SNPs) in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-specific protein 1 (LSP1)...
  47. pmc Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians
    Jingxuan Shan
    Genetic Medicine and Immunology Laboratory, Weill Cornell Medical College in Qatar, Qatar Foundation, Education City, P O Box 24144, Doha, Qatar
    Breast Cancer Res Treat 135:715-24. 2012
    ..G allele: OR = 1.55, P = 3 × 10(-6)) of FGFR2 gene; the rs8051542 of the TNRC9 gene (T vs. C allele: OR = 1.40, P = 4 × 10(-4)); the rs889312 of the MAP3K1 gene (C vs. A allele: OR = 1...
  48. doi Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
    Yongyong Shi
    Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio X Institutes, Ministry of Education, Shanghai Jiao Tong University, China
    Nat Genet 44:1020-5. 2012
    ..Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS...
  49. pmc Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
    Nick Orr
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Nat Genet 44:1182-4. 2012
    ..A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).
  50. pmc Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm
    Yadav Sapkota
    Cross Cancer Institute, Edmonton, Alberta, Canada
    PLoS ONE 8:e62550. 2013
    ..in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations. Since the original report by Garcia-Closas et al...
  51. pmc A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population
    Xiaojing Zhang
    Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P R China Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P R China
    PLoS ONE 8:e72186. 2013
    Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes.
  52. pmc Genome-wide association study of breast cancer in the Japanese population
    Siew Kee Low
    Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e76463. 2013
    ..15-.28) and rs12922061 (combined P-value of 3.97 × 10(-10), OR = 1.23; 95% CI = 1.15-.31) on chromosome 16q12 (TOX3-LOC643714)...
  53. doi Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 gene
    Pablo Fernandez-Navarro
    National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Eur J Cancer 49:474-81. 2013
    ....
  54. pmc Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation
    Erica S Rinella
    Department of Surgery, New York University Langone Medical Center, New York, NY, USA
    Hum Genet 132:523-36. 2013
    ..2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator ..
  55. doi Association of low-penetrance alleles with male breast cancer risk and clinicopathological characteristics: results from a multicenter study in Italy
    L Ottini
    Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
    Breast Cancer Res Treat 138:861-8. 2013
    ..71; 95 % CI: 1.43-2.05; p = 0.0001), rs3803662/TOX3 (OR = 1.59; 95 % CI: 1.32-1.92; p = 0.0001), and rs2981582/FGFR2 (OR = 1.26; 95 % CI: 1.05-1.50; p = 0.013)...
  56. pmc Genetic susceptibility to triple-negative breast cancer
    Kristen N Stevens
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Res 73:2025-30. 2013
    ..association studies and other large-scale genotyping efforts have also been associated with risk of TNBC (TOX3, ESR1, RAD51L1, TERT, 19p13.1, 20q11, MDM4, 2p24.1, and FTO). Furthermore, variation in the 19p13...
  57. pmc Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers
    Mathewos Tessema
    Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
    PLoS ONE 7:e34850. 2012
    ..Extension of these assays to TOX, TOX3, and TOX4 genes that share similar genomic structure and protein homology with TOX2 revealed distinct methylation ..
  58. doi Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Erasmus MC, Building Be, Room 400, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Breast Cancer Res Treat 133:843-51. 2012
    ..we examined the association of SNPs tagging the low-risk breast cancer loci in or near FGFR2, LSP1, MAP3K1, H19, TOX3, POU5F1P1, MYC, and 2q35, with clinical, pathological characteristics, prognosis, and mRNA expression of the ..
  59. pmc TOX3 regulates calcium-dependent transcription in neurons
    Shauna H Yuan
    Department of Neuroscience and Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0366
    Proc Natl Acad Sci U S A 106:2909-14. 2009
    We report the cloning and characterization of TOX3, a high mobility group box protein involved in mediating calcium-dependent transcription. TOX3 was identified as a calcium-dependent transactivator using the Transactivator Trap screen...
  60. pmc Association of breast cancer susceptibility variants with risk of pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:3044-8. 2009
    ..Recently, several breast cancer susceptibility loci have been identified through genome-wide association studies. Here we evaluated possible associations between these single nucleotide polymorphisms (SNP) and pancreatic cancer risk...
  61. pmc Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK
    Hum Mol Genet 18:4442-56. 2009
    ..In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers...
  62. doi Mammary tumor development in dogs is associated with BRCA1 and BRCA2
    Patricio Rivera
    Department of Clinical Sciences, Division of Small Animal Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Cancer Res 69:8770-4. 2009
    ..Here, we evaluate 10 human breast cancer genes (BRCA1, BRCA2, CHEK2, ERBB2, FGFR2, LSP1, MAP3K1, RCAS1, TOX3, and TP53) for association with CMTs...
  63. doi Birth weight, breast cancer susceptibility loci, and breast cancer risk
    Rulla M Tamimi
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 21:689-96. 2010
    ....
  64. doi Common genetic variants associated with breast cancer and mammographic density measures that predict disease
    Fabrice Odefrey
    Department of Pathology and Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne 3053, Australia
    Cancer Res 70:1449-58. 2010
    ..These findings could help elucidate how those variants and mammographic density measures are associated with breast cancer susceptibility...
  65. doi Breast cancer susceptibility variants alter risks in familial disease
    Ayse Latif
    Department of Medical Genetics, St Mary s Hospital, Manchester Academic Health Sciences Centre MAHSC, University of Manchester, Manchester M13 0JH, UK
    J Med Genet 47:126-31. 2010
    ..Recent candidate and genome-wide association studies have identified variants altering susceptibility to breast cancer...
  66. pmc Low-risk susceptibility alleles in 40 human breast cancer cell lines
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Cancer 9:236. 2009
    ..The mechanism by which the low-risk SNPs confer breast cancer risks is currently unclear. The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes...
  67. doi TNRC9/LOC643714 polymorphisms are not associated with breast cancer risk in Chinese women
    Lihua Li
    Oncology Institute of Wuxi, The Fourth Affiliated Hospital of Soochow University, Wuxi, Jiangsu Province, China
    Eur J Cancer Prev 18:285-90. 2009
    ..Genetic variation in trinucleotide repeat containing 9 (TNRC9) and the hypothetical gene LOC643714 (TNRC9/LOC643714) is a newly described risk factor for breast cancer...
  68. pmc Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study
    Honglin Song
    CR UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
    Hum Mol Genet 18:2297-304. 2009
    ..Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ..
  69. doi Breast cancer susceptibility variants alter risk in familial ovarian cancer
    A Latif
    Genetic Medicine, Manchester Academic Heath Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary s Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, UK
    Fam Cancer 9:503-6. 2010
    ..mutation positive and 104 BRCA1/2 mutation negative) with familial ovarian cancer were genotyped for FGFR2, TNRC9/TOX3 and CASP8 variants. The p...
  70. pmc FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women
    Jill S Barnholtz-Sloan
    Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
    Carcinogenesis 31:1417-23. 2010
    ..17-1.81]. Associations were observed for SNPs in FGFR2, LSP1, H19, TLR1/TLR6 and RELN for AA; FGFR2, TNRC9, H19 and MAP3K1 for Whites; FGFR2, TNRC9, Msc5A1 and chromosome 8q for women > or =50 years old and FGFR2 and ..
  71. pmc Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort
    Christy G Woolcott
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R10. 2009
    ..Mammographic density is a strong risk factor for breast cancer. Our objective was to examine its association with polymorphisms identifying breast cancer susceptibility loci that were ascertained in recent genome-wide association studies...
  72. pmc Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study
    Ruth C Travis
    Cancer Epidemiology Unit, University of Oxford, Oxford, UK
    Lancet 375:2143-51. 2010
    ..To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study...
  73. pmc Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men
    Nick Orr
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS Genet 7:e1002290. 2011
    ..1) (OR = 1.39, p = 0.004), rs2981579 (FGFR2) (OR = 1.18, p = 0.03), and rs3803662 (TOX3) (OR = 1.48, p = 4.04×10⁻⁶)...
  74. ncbi [Implications of genetic risk factors in breast cancer: culprit genes and associated malignancies]
    Dominique Stoppa-Lyonnet
    Génétique oncologique, Institut Curie Hôpital, 26, rue d Ulm 75248 Paris, INSERM U830, Universite Paris Descartes
    Bull Acad Natl Med 193:2063-83; discussion 2084-5. 2009
    ..e., polymorphisms located within predisposing gene loci (FGFR2, TNRC9, MAP3K1, LSP1, etc.) or intergenic regions...
  75. pmc The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer
    William Tapper
    Human Genetics and Cancer Sciences Divisions, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK
    Breast Cancer Res 10:R108. 2008
    ..Common variants that alter breast cancer risk are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk and tumour characteristics...
  76. pmc Breast cancer susceptibility: current knowledge and implications for genetic counselling
    Tim Ripperger
    Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 17:722-31. 2009
    ..breast cancer susceptibility polymorphisms within genes as well as in chromosomal loci with no known genes (FGFR2, TOX3, LSP1, MAP3K1, TGFB1, 2q35 and 8q)...
  77. pmc Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction
    Antonis C Antoniou
    Center for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Cancer Res 70:9742-54. 2010
    The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers...
  78. pmc Genetic susceptibility loci for breast cancer by estrogen receptor status
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Clin Cancer Res 14:8000-9. 2008
    ..consortial studies has led to the discovery of novel breast cancer susceptibility loci in genic (CASP8, FGFR2, TNRC9, MAP3K1, LSP1) and nongenic regions (8q24, 2q35, 5p12) of the genome, and to the finding of substantial ..
  79. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  80. pmc Breast cancer susceptibility loci and mammographic density
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Breast Cancer Res 10:R66. 2008
    ....
  81. doi Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
    Sihua Peng
    Department of Pathology, Zhejiang University School of Medicine, Zhejiang, People s Republic of China
    Breast Cancer Res Treat 127:309-24. 2011
    ..rs2981579, rs1219648, and rs2981582), LSP1 (rs909116), RNF146 (rs2180341), SLC4A7 (rs4973768), MRPS30 (rs7716600), TOX3 (rs3803662 and rs4784227), ZNF365 (rs10995190), rs889312, rs614367, rs13281615, rs13387042, rs11249433, rs1011970, ..
  82. pmc Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
    Martha L Slattery
    University of Utah, Salt Lake City, UT, 84108, USA
    Breast Cancer Res Treat 129:531-9. 2011
    ..We focus on TNRC9 rs3803662, FGFR2 rs1219648 and rs2981582, MAP3K1 rs889312, and 2q35 rs13387042, to replicate in the 4-Corner's ..
  83. pmc Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk
    Mitchell H Gail
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 8032, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 100:1037-41. 2008
    ..These seven SNPs were located in FGFR2, TNRC9 (now known as TOX3), MAP3K1, LSP1, CASP8, chromosomal region 8q, and chromosomal region 2q35...
  84. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
    ..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
  85. pmc Common breast cancer susceptibility loci are associated with triple-negative breast cancer
    Kristen N Stevens
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 71:6240-9. 2011
    ..We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13...

Research Grants14

  1. A Follow-up Study for Causes of Illness in Black Women
    Lynn Rosenberg; Fiscal Year: 2013
    ..Under separate funding, we are assessing two genes, FGFR2 and TNRC9 (which have been associated with breast cancer risk in genome wide association studies of European-ancestry women) ..
  2. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006
    ..These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease. ..
  3. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  4. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  5. P21 INDUCTION BY BRCA2
    Fergus Couch; Fiscal Year: 2002
    ....
  6. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  7. Characterization of the Chromosome 17q23 Amplicon
    Fergus Couch; Fiscal Year: 2006
    ..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
  8. Cancer Risk Reduction and Diet: A Cohort Study of Women
    Wei Zheng; Fiscal Year: 2007
    ..The results from this study may guide new strategies in the primary prevention of common cancer in both Western and Asian women. ..
  9. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  10. Vitamin D and Mammographic Density
    Rulla Tamimi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. BENIGN BREAST DISEASE AND RISK OF BREAST CANCER
    Rulla Tamimi; Fiscal Year: 2009
    ..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
  12. MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCER
    Wei Zheng; Fiscal Year: 2009
    ..Results from this study will be valuable in identifying high risk women for primary and secondary prevention of breast cancer. ..
  13. The Nashville Breast Health Study
    Wei Zheng; Fiscal Year: 2009
    ..Studies investigating gene-gene and gene-environment interaction could provide valuable information in identifying high-risk individuals for designing cost-effective preventive strategies for breast cancer. ..
  14. Tumor Markers and Recurrent Adenomas: A Follow-up Study
    Wei Zheng; Fiscal Year: 2006
    ..This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention. ..