Genomes and Genes
Gene Symbol: TOX3
Description: TOX high mobility group box family member 3
Alias: CAGF9, TNRC9, TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, trinucleotide repeat-containing gene 9 protein
- A combined analysis of genome-wide association studies in breast cancerJingmei Li
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 17177 Stockholm, Sweden
Breast Cancer Res Treat 126:717-27. 2011..More effort focused in these aspects of oncology can potentially open up promising avenues for the understanding of breast cancer and its prevention...
- Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patientsKari Hemminki
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany
Int J Cancer 126:2858-62. 2010..43, 95% CI 1.30-1.59, p-value = 1.24 x 10(-12)) and for TNRC9 (OR = 1.33, 95% CI 1.19-1.46, p-value = 1.54 x 10(-7))...
- Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese populationJie Liang
Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, 210029 Nanjing, China
Breast Cancer Res Treat 124:237-41. 2010Trinucleotide repeat-containing 9 (TNRC9), a high mobility group chromatin-associated protein, has been implicated in breast cancer metastasis to the bone...
- Performance of common genetic variants in breast-cancer risk modelsSholom Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 5050, MSC 7244, Bethesda, MD 20892, USA
N Engl J Med 362:986-93. 2010..Genomewide association studies have identified multiple genetic variants associated with breast cancer. The extent to which these variants add to existing risk-assessment models is unknown...
- Fine scale mapping of the breast cancer 16q12 locusMiriam S Udler
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Hum Mol Genet 19:2507-15. 2010..containing the largely uncharacterized hypothetical gene LOC643714, a short intergenic region and the 5' end of TOX3. Re-sequencing this segment in European subjects identified 293 common polymorphisms, including a set of 26 highly ..
- Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American womenEdward A Ruiz-Narváez
Slone Epidemiology Center at Boston University, Department of Epidemiology, School of Public Health, 1010 Commonwealth Avenue, Boston MA 02215, USA
Cancer Epidemiol Biomarkers Prev 19:1320-7. 2010The rs3803662 single nucleotide polymorphism (SNP) in the TOX3/LOC643714 region was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry and has been ..
- Genome-wide association study identifies five new breast cancer susceptibility lociClare Turnbull
Section of Cancer Genetics, The Institute of Cancer Research, Sutton, Surrey, UK
Nat Genet 42:504-7. 2010....
- Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer ConsortiumJirong Long
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS Genet 6:e1001002. 2010..1 and demonstrate the utility of conducting genetic association studies in populations with different genetic architectures...
- Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility lociGillian K Reeves
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
JAMA 304:426-34. 2010..There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination...
- Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjectsMin Bin Chen
Department of Oncology, Kunshan People s Hospital Affiliated To Jiangsu University, Kunshan, 215300, Jiangsu, China
Breast Cancer Res Treat 126:177-83. 2011Trinucleotide repeat containing 9 (TNRC9) is a gene located at chromosome 16q12. Although of an uncertain function, it is a newly described risk factor for breast cancer...
- TOX defines a conserved subfamily of HMG-box proteinsEmmett O'Flaherty
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA92037, USA
BMC Genomics 4:13. 2003..We recently identified an HMG-box protein involved in T cell development, designated TOX, which is highly conserved in humans and mice...
- TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complexSonja Dittmer
Department of Neurology, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
J Cell Sci 124:252-60. 2011b>TOX3 is a nuclear protein containing a high mobility group (HMG)-box domain, which regulates Ca(2+)-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB)...
- Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association studyOlivia Fletcher
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
J Natl Cancer Inst 103:425-35. 2011..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
- Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1Juliane Winkelmann
Institute of Human Genetics, Technische Universitat Munchen, Munich, Germany
PLoS Genet 7:e1002171. 2011..03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767.
- Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expressionRichard Cowper-Sal Lari
Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire, USA
Nat Genet 44:1191-8. 2012..SNPs modulate the affinity of chromatin for FOXA1 at distal regulatory elements, thereby resulting in allele-specific gene expression, which is exemplified by the effect of the rs4784227 SNP on the TOX3 gene within the 16q12.1 risk locus.
- The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patientsEydis Th Gudmundsdottir
Department of Pathology, Landspitali University Hospital, Hringbraut, 101, Reykjavik, Iceland
BMC Cancer 12:621. 2012..allele of SNP rs3803662 has been shown to correlate with increased breast cancer risk and with lower expression of TOX3. The SNP is closely located to TOX3 residing within an uncharacterised gene LOC643714...
- TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressivenessJingxuan Shan
Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar Qatar Foundation, Qatar
Cancer Res 73:2840-9. 2013..The breast cancer gene trinucleotide-repeat-containing 9 (TNRC9; TOX3) has been associated with disease susceptibility but its function is undetermined...
- Genome-wide association studies identify four ER negative-specific breast cancer risk lociMontserrat Garcia-Closas
1 Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK 3
Nat Genet 45:392-8, 398e1-2. 2013..0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers...
- TOX3 mutations in breast cancerJames Owain Jones
Cambridge Research Institute, Cancer Research UK, Cambridge, United Kingdom
PLoS ONE 8:e74102. 2013b>TOX3 maps to 16q12, a region commonly lost in breast cancers and recently implicated in the risk of developing breast cancer. However, not much is known of the role of TOX3 itself in breast cancer biology...
- Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern ChinaXuanqiu He
The First Clinical College, Southern Medical University, Guangzhou 510515, China
Int J Mol Sci 15:2130-41. 2014..risk is currently unclear, with contradictory evidence on the role of single nucleotide polymorphisms (SNPs) in TOX3/LOC643714 as a breast cancer susceptibility locus...
- Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristicsMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
PLoS Genet 4:e1000054. 2008..polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with ..
- Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriersAntonis C Antoniou
Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
Am J Hum Genet 82:937-48. 2008..association study has shown that common alleles at single nucleotide polymorphisms (SNPs) in FGFR2 (rs2981582), TNRC9 (rs3803662), and MAP3K1 (rs889312) are associated with increased breast cancer risks in the general population...
- Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer casesPetra E A Huijts
Department of Clinical Genetics, K5 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Breast Cancer Res 9:R78. 2007..Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer...
- Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancerSimon N Stacey
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:865-9. 2007..rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to ..
- Evaluation of 11 breast cancer susceptibility loci in African-American womenWei Zheng
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
- Genome-wide association study identifies novel breast cancer susceptibility lociDouglas F Easton
CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Nature 447:1087-93. 2007..Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0...
- A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)Gilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 41:579-84. 2009..1 (rs999737; P = 1.74 x 10(-7)) localizes to RAD51L1, a gene in the homologous recombination DNA repair pathway. We also confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1...
- cDNAs with long CAG trinucleotide repeats from human brainR L Margolis
Laboratory of Molecular Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Hum Genet 100:114-22. 1997..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment...
- A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han womenF Chen
Life Sciences school of Hubei University, Wuchang, Wuhan, China
Genet Mol Res 13:182-7. 2014A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry...
- Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat functionRajesh Ramakrishnan
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
Retrovirology 9:90. 2012..Nine CCAPs are novel, while three were previously identified as Core P-TEFb, the 7SK snRNP, and the Super-Elongation Complex. We have investigated the role of five newly identified CCAPs in Tat function and viral gene expression...
- The relationship between eight GWAS-identified single-nucleotide polymorphisms and primary breast cancer outcomesSoley Bayraktar
Department of Medical Oncology, Mercy Cancer Center, Ardmore, Oklahoma, USA
Oncologist 18:493-500. 2013..We investigated whether eight risk SNPs identified in GWAS were associated with breast cancer disease-free survival (DFS) and overall survival (OS) rates...
- Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutationsMonique A de Bruin
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
Fam Cancer 11:429-39. 2012..01). Asians had a higher frequency of risk-associated alleles in MAP3K1 (88 vs. 59 %, p = 0.005) and TOX3/TNRC9 (88 vs. 55 %, p = 0.0002)...
- Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25Laura Fejerman
Division of General Internal Medicine, Department of Medicine, Institute of Human Genetics, University of California San Fancisco, San Francisco, California 94158, USA
Nat Commun 5:5260. 2014..These results highlight the importance of conducting research in diverse populations. ..
- Phenotype and Tissue Expression as a Function of Genetic Risk in Polycystic Ovary SyndromeCindy T Pau
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 12:e0168870. 2017..The IRF1, SUMO1P1 and KRR1 loci may confer PCOS risk in development. The TOX3 and GATA4 loci appear to be involved in inflammation and its consequences...
- Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate CellsDong Gui Hu
Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, Flinders University School of Medicine, Flinders Medical Centre, Adelaide 5042, Australia
Int J Mol Sci 18:. 2016..of prostate cancer (PCGEM1, PEG3, EPHA3, and EFNB2) or other types of human cancers (TOX3, ST8SIA4, and SLITRK3), and genes that are diagnostic/prognostic biomarkers of prostate cancer (<..
- Increased risk of breast cancer in individuals carrying the TNRC9 rs3803662 C>T polymorphism: a meta-analysis of case-control studiesQ Wang
Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China
Genet Mol Res 15:. 2016Currently, the relationship between the trinucleotide repeat containing 9 (TNRC9) rs3803662 C>T polymorphism and risk of breast cancer (BC) is uncertain...
- The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese populationChaowen Jiang
Institute of Human Respiratory Disease, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
Oncotarget 7:59742-59753. 2016..to test our hypothesis that the previously identified breast cancer risk-associated genetic polymorphisms at the TOX3/LOC643714 locus might contribute to lung cancer risk, 16 SNPs at the TOX3/LOC643714 locus were evaluated in a Han ..
- TOX3 regulates neural progenitor identitySanjeeb Kumar Sahu
Institute of Molecular Biology, IMB, Mainz, Germany
Biochim Biophys Acta 1859:833-40. 2016The human genomic locus for the transcription factor TOX3 has been implicated in susceptibility to restless legs syndrome and breast cancer in genome-wide association studies, but the physiological role of TOX3 remains largely unknown...
- TOX3 protein expression is correlated with pathological characteristics in breast cancerCui Cui Han
Institute of Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang 161042, P R China
Oncol Lett 11:1762-1768. 2016b>TOX3 is a newly identified gene that has been observed to correlate with breast cancer by genome-wide association studies (GWAS) in recent years...
- TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer riskYing Chen
Department of Radiology, Shengjing Hospital Affiliated to China Medical University, No 36, Sanhao ST, Heping District, Shenyang, Liaoning Province, 110004, China
World J Surg Oncol 14:50. 2016..the association of fibroblast growth factor receptor 2 (FGFR2) rs2981582, trinucleotide-repeat-containing 9 (TNRC9) rs3803662, rs12443621, and leukocyte-specific protein 1 (LSP1) rs3817198 polymorphisms with breast cancer and ..
- Relationship between five GWAS-identified single nucleotide polymorphisms and female breast cancer in the Chinese Han populationYaning He
Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University Henan Tumor Hospital, Zhengzhou, 450000, China
Tumour Biol 37:9739-44. 2016..Different genotypes of rs3803662 (TOX3)/ (TNRC9)) in the case group and the control group are statistically significant (P = 0...
- [Establishment of breast cancer MDA-MB-231 cell line stably over-expressing human TOX high mobility group box family member 3]Cuicui Han
Basic Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30:1154-8. 2014To construct the lentiviral expression vector of human TOX high mobility group box family member 3 (TOX3) gene and the MDA-MB-231 cell line which stably over-expresses TOX3 gene.
- Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American populationIsabel Elematore
Human Genetics Program, Institute of Biomedical Sciences ICBM, School of Medicine, University of Chile, Av Independencia 1027, P O Box 70061, Santiago, Chile
Mol Biol Rep 41:3715-22. 2014..In the present study, we evaluated the association between rs3803662 (TOX3, also known as TNRC9), rs13387042 (2q35), and rs13281615 (8q24) with BC risk in 344 Chilean BRCA1/2-negative BC cases and in 801 ..
- A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese populationAiko Sueta
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Breast Cancer Res Treat 132:711-21. 2012..risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936...
- The role of genetic breast cancer susceptibility variants as prognostic factorsPeter A Fasching
University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen Nuremberg, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Hum Mol Genet 21:3926-39. 2012..CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC ..
- Breast cancer genome-wide association studies: there is strength in numbersD Fanale
Department of Surgical and Oncological Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy
Oncogene 31:2121-8. 2012..GWAS) in BC revealed single nucleotide polymorphisms (SNPs) in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-specific protein 1 (LSP1)...
- Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in TunisiansJingxuan Shan
Genetic Medicine and Immunology Laboratory, Weill Cornell Medical College in Qatar, Qatar Foundation, Education City, P O Box 24144, Doha, Qatar
Breast Cancer Res Treat 135:715-24. 2012..G allele: OR = 1.55, P = 3 × 10(-6)) of FGFR2 gene; the rs8051542 of the TNRC9 gene (T vs. C allele: OR = 1.40, P = 4 × 10(-4)); the rs889312 of the MAP3K1 gene (C vs. A allele: OR = 1...
- Genome-wide association study identifies eight new risk loci for polycystic ovary syndromeYongyong Shi
Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio X Institutes, Ministry of Education, Shanghai Jiao Tong University, China
Nat Genet 44:1020-5. 2012..Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS...
- Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer riskNick Orr
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
Nat Genet 44:1182-4. 2012..A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).
- Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigmYadav Sapkota
Cross Cancer Institute, Edmonton, Alberta, Canada
PLoS ONE 8:e62550. 2013..in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations. Since the original report by Garcia-Closas et al...
- A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese populationXiaojing Zhang
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P R China Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P R China
PLoS ONE 8:e72186. 2013Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes.
- Genome-wide association study of breast cancer in the Japanese populationSiew Kee Low
Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
PLoS ONE 8:e76463. 2013..15-.28) and rs12922061 (combined P-value of 3.97 × 10(-10), OR = 1.23; 95% CI = 1.15-.31) on chromosome 16q12 (TOX3-LOC643714)...
- Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 genePablo Fernandez-Navarro
National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain
Eur J Cancer 49:474-81. 2013....
- Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutationErica S Rinella
Department of Surgery, New York University Langone Medical Center, New York, NY, USA
Hum Genet 132:523-36. 2013..2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator ..
- Association of low-penetrance alleles with male breast cancer risk and clinicopathological characteristics: results from a multicenter study in ItalyL Ottini
Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Breast Cancer Res Treat 138:861-8. 2013..71; 95 % CI: 1.43-2.05; p = 0.0001), rs3803662/TOX3 (OR = 1.59; 95 % CI: 1.32-1.92; p = 0.0001), and rs2981582/FGFR2 (OR = 1.26; 95 % CI: 1.05-1.50; p = 0.013)...
- Genetic susceptibility to triple-negative breast cancerKristen N Stevens
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Cancer Res 73:2025-30. 2013..association studies and other large-scale genotyping efforts have also been associated with risk of TNBC (TOX3, ESR1, RAD51L1, TERT, 19p13.1, 20q11, MDM4, 2p24.1, and FTO). Furthermore, variation in the 19p13...
- Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancersMathewos Tessema
Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
PLoS ONE 7:e34850. 2012..Extension of these assays to TOX, TOX3, and TOX4 genes that share similar genomic structure and protein homology with TOX2 revealed distinct methylation ..
- Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genesMuhammad Riaz
Department of Medical Oncology, Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Erasmus MC, Building Be, Room 400, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Breast Cancer Res Treat 133:843-51. 2012..we examined the association of SNPs tagging the low-risk breast cancer loci in or near FGFR2, LSP1, MAP3K1, H19, TOX3, POU5F1P1, MYC, and 2q35, with clinical, pathological characteristics, prognosis, and mRNA expression of the ..
- TOX3 regulates calcium-dependent transcription in neuronsShauna H Yuan
Department of Neuroscience and Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0366
Proc Natl Acad Sci U S A 106:2909-14. 2009We report the cloning and characterization of TOX3, a high mobility group box protein involved in mediating calcium-dependent transcription. TOX3 was identified as a calcium-dependent transactivator using the Transactivator Trap screen...
- Association of breast cancer susceptibility variants with risk of pancreatic cancerFergus J Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 18:3044-8. 2009..Recently, several breast cancer susceptibility loci have been identified through genome-wide association studies. Here we evaluated possible associations between these single nucleotide polymorphisms (SNP) and pancreatic cancer risk...
- Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriersAntonis C Antoniou
Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK
Hum Mol Genet 18:4442-56. 2009..In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers...
- Mammary tumor development in dogs is associated with BRCA1 and BRCA2Patricio Rivera
Department of Clinical Sciences, Division of Small Animal Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
Cancer Res 69:8770-4. 2009..Here, we evaluate 10 human breast cancer genes (BRCA1, BRCA2, CHEK2, ERBB2, FGFR2, LSP1, MAP3K1, RCAS1, TOX3, and TP53) for association with CMTs...
- Birth weight, breast cancer susceptibility loci, and breast cancer riskRulla M Tamimi
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 21:689-96. 2010....
- Common genetic variants associated with breast cancer and mammographic density measures that predict diseaseFabrice Odefrey
Department of Pathology and Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne 3053, Australia
Cancer Res 70:1449-58. 2010..These findings could help elucidate how those variants and mammographic density measures are associated with breast cancer susceptibility...
- Breast cancer susceptibility variants alter risks in familial diseaseAyse Latif
Department of Medical Genetics, St Mary s Hospital, Manchester Academic Health Sciences Centre MAHSC, University of Manchester, Manchester M13 0JH, UK
J Med Genet 47:126-31. 2010..Recent candidate and genome-wide association studies have identified variants altering susceptibility to breast cancer...
- Low-risk susceptibility alleles in 40 human breast cancer cell linesMuhammad Riaz
Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
BMC Cancer 9:236. 2009..The mechanism by which the low-risk SNPs confer breast cancer risks is currently unclear. The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes...
- TNRC9/LOC643714 polymorphisms are not associated with breast cancer risk in Chinese womenLihua Li
Oncology Institute of Wuxi, The Fourth Affiliated Hospital of Soochow University, Wuxi, Jiangsu Province, China
Eur J Cancer Prev 18:285-90. 2009..Genetic variation in trinucleotide repeat containing 9 (TNRC9) and the hypothetical gene LOC643714 (TNRC9/LOC643714) is a newly described risk factor for breast cancer...
- Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association studyHonglin Song
CR UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
Hum Mol Genet 18:2297-304. 2009..Initially, three SNPs (rs2107425 in MRPL23, rs7313833 in PTHLH, rs3803662 in TNRC9) were weakly associated with ovarian cancer risk and one SNP (rs4954956 in NXPH2) was associated with serous ..
- Breast cancer susceptibility variants alter risk in familial ovarian cancerA Latif
Genetic Medicine, Manchester Academic Heath Science Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary s Hospital, University of Manchester, Oxford Road, Manchester M13 9WL, UK
Fam Cancer 9:503-6. 2010..mutation positive and 104 BRCA1/2 mutation negative) with familial ovarian cancer were genotyped for FGFR2, TNRC9/TOX3 and CASP8 variants. The p...
- FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger womenJill S Barnholtz-Sloan
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106 5065, USA
Carcinogenesis 31:1417-23. 2010..17-1.81]. Associations were observed for SNPs in FGFR2, LSP1, H19, TLR1/TLR6 and RELN for AA; FGFR2, TNRC9, H19 and MAP3K1 for Whites; FGFR2, TNRC9, Msc5A1 and chromosome 8q for women > or =50 years old and FGFR2 and ..
- Association between breast cancer susceptibility loci and mammographic density: the Multiethnic CohortChristy G Woolcott
Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
Breast Cancer Res 11:R10. 2009..Mammographic density is a strong risk factor for breast cancer. Our objective was to examine its association with polymorphisms identifying breast cancer susceptibility loci that were ascertained in recent genome-wide association studies...
- Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women StudyRuth C Travis
Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Lancet 375:2143-51. 2010..To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across the other risk factors in a large UK prospective study...
- Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in menNick Orr
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
PLoS Genet 7:e1002290. 2011..1) (OR = 1.39, p = 0.004), rs2981579 (FGFR2) (OR = 1.18, p = 0.03), and rs3803662 (TOX3) (OR = 1.48, p = 4.04×10⁻⁶)...
- [Implications of genetic risk factors in breast cancer: culprit genes and associated malignancies]Dominique Stoppa-Lyonnet
Génétique oncologique, Institut Curie Hôpital, 26, rue d Ulm 75248 Paris, INSERM U830, Universite Paris Descartes
Bull Acad Natl Med 193:2063-83; discussion 2084-5. 2009..e., polymorphisms located within predisposing gene loci (FGFR2, TNRC9, MAP3K1, LSP1, etc.) or intergenic regions...
- The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancerWilliam Tapper
Human Genetics and Cancer Sciences Divisions, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK
Breast Cancer Res 10:R108. 2008..Common variants that alter breast cancer risk are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk and tumour characteristics...
- Breast cancer susceptibility: current knowledge and implications for genetic counsellingTim Ripperger
Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Eur J Hum Genet 17:722-31. 2009..breast cancer susceptibility polymorphisms within genes as well as in chromosomal loci with no known genes (FGFR2, TOX3, LSP1, MAP3K1, TGFB1, 2q35 and 8q)...
- Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk predictionAntonis C Antoniou
Center for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Cancer Res 70:9742-54. 2010The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers...
- Genetic susceptibility loci for breast cancer by estrogen receptor statusMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
Clin Cancer Res 14:8000-9. 2008..consortial studies has led to the discovery of novel breast cancer susceptibility loci in genic (CASP8, FGFR2, TNRC9, MAP3K1, LSP1) and nongenic regions (8q24, 2q35, 5p12) of the genome, and to the finding of substantial ..
- Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control studyRoger L Milne
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
Breast Cancer Res 12:R110. 2010....
- Breast cancer susceptibility loci and mammographic densityRulla M Tamimi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
Breast Cancer Res 10:R66. 2008....
- Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studiesSihua Peng
Department of Pathology, Zhejiang University School of Medicine, Zhejiang, People s Republic of China
Breast Cancer Res Treat 127:309-24. 2011..rs2981579, rs1219648, and rs2981582), LSP1 (rs909116), RNF146 (rs2180341), SLC4A7 (rs4973768), MRPS30 (rs7716600), TOX3 (rs3803662 and rs4784227), ZNF365 (rs10995190), rs889312, rs614367, rs13281615, rs13387042, rs11249433, rs1011970, ..
- Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United StatesMartha L Slattery
University of Utah, Salt Lake City, UT, 84108, USA
Breast Cancer Res Treat 129:531-9. 2011..We focus on TNRC9 rs3803662, FGFR2 rs1219648 and rs2981582, MAP3K1 rs889312, and 2q35 rs13387042, to replicate in the 4-Corner's ..
- Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer riskMitchell H Gail
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 8032, Bethesda, MD 20892 7244, USA
J Natl Cancer Inst 100:1037-41. 2008..These seven SNPs were located in FGFR2, TNRC9 (now known as TOX3), MAP3K1, LSP1, CASP8, chromosomal region 8q, and chromosomal region 2q35...
- Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortiumDaniele Campa
Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Natl Cancer Inst 103:1252-63. 2011..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
- Common breast cancer susceptibility loci are associated with triple-negative breast cancerKristen N Stevens
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Res 71:6240-9. 2011..We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13...
- A Follow-up Study for Causes of Illness in Black WomenLynn Rosenberg; Fiscal Year: 2013..Under separate funding, we are assessing two genes, FGFR2 and TNRC9 (which have been associated with breast cancer risk in genome wide association studies of European-ancestry women) ..
- Analysis of Ethnic Admixture in Lung CancerJill Barnholtz Sloan; Fiscal Year: 2006..These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- P21 INDUCTION BY BRCA2Fergus Couch; Fiscal Year: 2002....
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- Characterization of the Chromosome 17q23 AmpliconFergus Couch; Fiscal Year: 2006..Thus, the project may involve a complete transition from benchtop to bedside. Finally, the amplified and overexpressed genes may prove useful as important targets of gene, pharmacological, and immunological therapy in the future. ..
- Cancer Risk Reduction and Diet: A Cohort Study of WomenWei Zheng; Fiscal Year: 2007..The results from this study may guide new strategies in the primary prevention of common cancer in both Western and Asian women. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- Vitamin D and Mammographic DensityRulla Tamimi; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- BENIGN BREAST DISEASE AND RISK OF BREAST CANCERRulla Tamimi; Fiscal Year: 2009..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
- MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCERWei Zheng; Fiscal Year: 2009..Results from this study will be valuable in identifying high risk women for primary and secondary prevention of breast cancer. ..
- The Nashville Breast Health StudyWei Zheng; Fiscal Year: 2009..Studies investigating gene-gene and gene-environment interaction could provide valuable information in identifying high-risk individuals for designing cost-effective preventive strategies for breast cancer. ..
- Tumor Markers and Recurrent Adenomas: A Follow-up StudyWei Zheng; Fiscal Year: 2006..This study is likely to provide valuable information for identifying high-risk adenoma patients for close surveillance and chemoprevention. ..