TOMM40

Summary

Gene Symbol: TOMM40
Description: translocase of outer mitochondrial membrane 40
Alias: C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40, mitochondrial import receptor subunit TOM40 homolog, mitochondrial outer membrane protein, p38.5, protein Haymaker, translocase of outer membrane 40 kDa subunit homolog, translocase of outer mitochondrial membrane 40 homolog
Species: human

Top Publications

  1. pmc The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death
    Syed Mohammad Moin
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India
    J Biol Chem 282:21124-33. 2007
  2. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
  3. ncbi Dissection of the mitochondrial import and assembly pathway for human Tom40
    Adam D Humphries
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    J Biol Chem 280:11535-43. 2005
  4. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
  5. pmc A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
    Richard Abraham
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    BMC Med Genomics 1:44. 2008
  6. doi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
  7. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
  8. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
  9. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
  10. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010

Research Grants

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
  2. UNDERSTANDING THE ROLE OF MITOCHONDRIAL IMPORT IN AMYOTROPHIC LATERAL SCLEROSIS
    Matthew Crisp; Fiscal Year: 2013
  3. Robyn A Honea; Fiscal Year: 2015
  4. Genetic Factors that Impact the Risk of Alzheimer's Disease
    Allen D Roses; Fiscal Year: 2010
  5. A Study of APOE and TOMM40 in a large Cerebral Palsy Registry
    James A Blackman; Fiscal Year: 2010
  6. ORNIT FALEK; Fiscal Year: 2016
  7. MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMES
    Minu Chaudhuri; Fiscal Year: 2002
  8. Novel intervention strategy for mitochondrial ROS toxicity
    Yisang Yoon; Fiscal Year: 2006
  9. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
  10. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2006

Detail Information

Publications172 found, 100 shown here

  1. pmc The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death
    Syed Mohammad Moin
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110 067, India
    J Biol Chem 282:21124-33. 2007
    ..VDAC is a critical mitochondrial outer membrane protein, and its overexpression results in apoptosis...
  2. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..APOE epsilon4 genotype does not predict CSF apoE levels. Three SNPs within the TOMM40 gene, one APOE promoter SNP and two SNPs within distal APOE enhancer elements (ME1 and BCR) predict CSF apoE ..
  3. ncbi Dissection of the mitochondrial import and assembly pathway for human Tom40
    Adam D Humphries
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    J Biol Chem 280:11535-43. 2005
    b>Tom40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM complex), essential for protein import into mitochondria...
  4. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ....
  5. pmc A genome-wide association study for late-onset Alzheimer's disease using DNA pooling
    Richard Abraham
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    BMC Med Genomics 1:44. 2008
    ..In order to identify additional genetic risk loci we have conducted a genome-wide association (GWA) study in a large LOAD case - control sample, reducing costs through the use of DNA pooling...
  6. doi Examination of the current top candidate genes for AD in a genome-wide association study
    T M Feulner
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universität München TUM, Munich, Germany
    Mol Psychiatry 15:756-66. 2010
    ..Finally, our data confirm that GWAS, regardless of the platform, are valuable for the identification of genetic variants associated with AD...
  7. pmc Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA
    PLoS ONE 4:e6501. 2009
    ..With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown...
  8. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86)...
  9. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    ..Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease...
  10. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010
    ..phylogenetic analysis, we have identified a polymorphic poly-T variant, rs10524523, in the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene that provides greatly increased precision in the estimation of age of LOAD ..
  11. pmc Genome-wide scan of copy number variation in late-onset Alzheimer's disease
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
    J Alzheimers Dis 19:69-77. 2010
    ..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation...
  12. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..As expected, SNPs in the APOE and TOMM40 genes were confirmed as markers strongly associated with multiple brain regions...
  13. pmc Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Med Genet 11:55. 2010
    ..Here, we report single-locus and epistasis SNP effects on TC and HDL-C using the Framingham Heart Study (FHS) data...
  14. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  15. pmc Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities
    Adam C Naj
    Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Genet 6:e1001130. 2010
    ..This finding is noteworthy, as MTHFD1L may play a role in the generation of methionine from homocysteine and influence homocysteine-related pathways and as levels of homocysteine are a significant risk factor for LOAD development...
  16. pmc Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study
    Mi Ryung Han
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Neurol 10:90. 2010
    ..We carried out a genome-wide association study (GWAS) in order to better define the genetic backgrounds to these three states in relation to CSF levels...
  17. pmc Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    S Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202, USA
    Neurology 76:69-79. 2011
    ..We report a genome-wide association study (GWAS) of CSF biomarkers (Aβ1-42, t-tau, p-tau181p, p-tau181p/Aβ1-42, and t-tau/Aβ1-42)...
  18. pmc Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
    Joris Deelen
    Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Aging Cell 10:686-98. 2011
    ..71 (95% CI 0.65-0.77), P=3.39 × 10(-17) ]. This SNP, rs2075650, is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E (APOE) gene...
  19. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  20. pmc The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
    Sterling C Johnson
    Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Alzheimers Dement 7:456-65. 2011
    ..poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier ..
  21. pmc Cerebrospinal fluid cortisol concentrations in healthy elderly are affected by both APOE and TOMM40 variants
    Davide Bruno
    Nathan Kline Institute, Orangeburg, NY, USA
    Psychoneuroendocrinology 37:366-71. 2012
    ..In this study, we examined whether TOMM40 variants, which have been reported to influence age of onset of AD, also had an effect on CSF cortisol levels, in ..
  22. pmc TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease
    Su Hee Chu
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA
    Neurobiol Aging 32:2328.e1-9. 2011
    ..region in a small sample of LOAD subjects identified a variable length poly-T repeat sequence in the nearby gene, TOMM40, which may affect age of onset...
  23. pmc Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease
    Carlos Cruchaga
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 68:1013-9. 2011
    ..The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all the association signal is derived from APOE or whether there is an independent signal from a nearby gene...
  24. pmc Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    BMC Med Genet 12:123. 2011
    ....
  25. pmc Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants
    Davide Bruno
    Nathan Kline Institute, Orangeburg, NY 10962, USA
    Exp Gerontol 47:347-52. 2012
    ..We examined whether TOMM40 variants, which have been reported to influence age of onset of AD and are in linkage disequilibrium with APOE, ..
  26. pmc Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE
    Lynn M Bekris
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    J Hum Genet 57:18-25. 2012
    ..Luciferase reporter constructs containing haplotypes of APOE locus gene promoters; APOE, APOC1 and TOMM40, and regional putative enhancers; TOMM40 intervening sequence (IVS)2-4, TOMM40 IVS6 poly-T, as well as previously ..
  27. pmc Characterization of the poly-T variant in the TOMM40 gene in diverse populations
    Colton Linnertz
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 7:e30994. 2012
    We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of Alzheimer's disease and with cognitive performance in elderly...
  28. doi Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene
    Louise Hedskog
    KI Alzheimer s Disease Research Center, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society NVS, Stockholm, Sweden
    J Alzheimers Dis 31:527-36. 2012
    ..Recently the gene, TOMM40, which is in linkage disequilibrium with APOE, was identified to be associated with LOAD in genome-wide ..
  29. pmc A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
    Alzheimers Dement 8:381-8. 2012
    ..A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset...
  30. pmc Longitudinal modeling of cognitive aging and the TOMM40 effect
    Richard J Caselli
    Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA
    Alzheimers Dement 8:490-5. 2012
    b>TOMM40 (translocase of the outer mitochondrial membrane pore subunit) is in linkage disequilibrium with apolipoprotein E (APOE)...
  31. doi A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing
    G Davies
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 19:76-87. 2014
    ..One SNP--rs2075650, located in TOMM40 (translocase of the outer mitochondrial membrane 40 homolog)--had a genome-wide significant association with ..
  32. doi Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population
    Xiao Ying Ma
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No 5 Donghai Middle Road, Qingdao 266071, China
    Neuromolecular Med 15:279-87. 2013
    ..One interesting candidate gene for mitochondrial dysfunction in LOAD is the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene...
  33. pmc Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis
    Elizabeth G Holliday
    Centre for Clinical Epidemiology and Biostatistics, and School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 8:e53830. 2013
    ....
  34. doi Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms
    F L Mastaglia
    Australian Neuro Muscular Research Institute, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia Institute for Immunology and Infectious Diseases, Murdoch University, Western Australia, Australia Electronic address
    Neuromuscul Disord 23:969-74. 2013
    A polyT repeat in an intronic polymorphism (rs10524523) in the TOMM40 gene, which encodes an outer mitochondrial membrane translocase involved in the transport of amyloid-β and other proteins into mitochondria, has been implicated in ..
  35. pmc Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK Department of Psychology, University of Edinburgh, Edinburgh, UK Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine, Western General Hospital, Edinburgh, UK MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Neurobiol Aging 35:1513.e25-33. 2014
    ..g., age of onset). In the TOMM40 gene, the rs10524523 ("523") variable length poly-T repeat polymorphism has more recently been associated with ..
  36. ncbi Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and morphology
    L I Grad
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Curr Genet 36:137-46. 1999
    ..The presence of tetratricopeptide repeats (TPRs) in the TOM70 sequence and the enlarged shape of mitochondria lacking TOM70 raise the possibility that the protein also plays a role in the maintenance of mitochondrial morphology...
  37. ncbi Protein sorting between the outer and inner mitochondrial membranes: submitochondrial localization of cytochrome c1 whose presequence is replaced by the amino-terminal region of a 70 kDa outer membrane protein
    M Nakai
    Department of Biology, Faculty of Science, Osaka University
    J Biochem 106:181-7. 1989
    The amino-terminal region of a 70 kDa mitochondrial outer membrane protein of yeast and the presequence of cytochrome c1, an inner membrane protein exposed to the intermembrane space, are thought to be responsible for localizing the ..
  38. ncbi Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo
    Minu Chaudhuri
    Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA
    Curr Genet 44:85-94. 2003
    The TOM complex (translocase of the mitochondrial outer membrane) is a dynamic, multisubunit protein complex. Tom40 is the major component of the complex and forms the preprotein conducting pore...
  39. pmc Rpm2p, a component of yeast mitochondrial RNase P, acts as a transcriptional activator in the nucleus
    Vilius Stribinskis
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Mol Cell Biol 25:6546-58. 2005
    ..The ability of RPM2 alleles to suppress tom40-3, a temperature-sensitive mutant of a component of the mitochondrial import apparatus, correlates with their ..
  40. pmc The essentials of protein import in the degenerate mitochondrion of Entamoeba histolytica
    Pavel Dolezal
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia
    PLoS Pathog 6:e1000812. 2010
    ..membrane-located components of the protein import machinery that includes the outer membrane translocation channel Tom40 and membrane assembly protein Sam50. Using in vitro and in vivo systems we show that E...
  41. pmc Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity
    Helena Castro
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    PLoS ONE 5:e12607. 2010
    ..subcellular localization and membrane topology, which revealed that LiTXN3 is a tail-anchored (TA) mitochondrial outer membrane protein presenting, as characteristic of TA proteins, its N-terminal end (containing the redox-active ..
  42. doi Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    J Mol Biol 405:113-24. 2011
    ..of the outer mitochondrial membrane (TOM complex) involves the assembly of the central β-barrel forming protein Tom40 with six different subunits that are embedded in the membrane via α-helical transmembrane segments...
  43. ncbi Relationship between the peptide-sensitive channel and the mitochondrial outer membrane protein translocation machinery
    P Juin
    Service de Neurobiologie Physico Chimique, Centre National de la Recherche Scientifique, , Institut de Biologie Physico Chimique, 13 rue P et M Curie, 75005 Paris, France
    J Biol Chem 272:6044-50. 1997
    ..Taken together, the present data reinforce the hypothesis that the PSC is the pore responsible for the translocation of protein through the outer membrane...
  44. pmc In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
    Heftsi Azoulay-Zohar
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Biochem J 377:347-55. 2004
    ..Our studies relying on the purified mitochondrial outer membrane protein VDAC (voltage-dependent anion channel), isolated mitochondria or cells in culture suggested that ..
  45. ncbi Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10
    Chris Meisinger
    Institut für Biochemie und Molekularbiologie and the Fakultät für Biologie, Universitat Freiburg, 79104 Freiburg
    J Biol Chem 281:22819-26. 2006
    ..proteins, Mdm10 and the SAM(holo) complex play a selective role in beta-barrel biogenesis by promoting assembly of Tom40 but not of porin...
  46. pmc Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
    ..associated with LDL cholesterol and apolipoprotein B were located in LDLR, PCSK9, APOB, CELSR2, HMGCR, CETP, the TOMM40-APOE-C1-C2-C4 cluster, and the APOA5-A4-C3-A1 cluster; SNPs associated with HDL cholesterol and apolipoprotein AI ..
  47. doi Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins
    Nicolas Thornton
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, D 79104 Freiburg, Germany
    J Mol Biol 396:540-9. 2010
    ..complex is required for the assembly of precursors of the TOM complex, including not only the beta-barrel protein Tom40 but also a subset of alpha-helical subunits...
  48. doi Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A
    Romain Cartoni
    Department of Cell Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    Brain 133:1460-9. 2010
    ..Mitofusin 2 encodes a mitochondrial outer membrane protein that participates in mitochondrial fusion in mammalian cells...
  49. pmc Functional cooperation of mitochondrial protein import receptors in yeast
    L Ramage
    Biocenter, University of Basel, Switzerland
    EMBO J 12:4115-23. 1993
    We have identified a 20 kDa yeast mitochondrial outer membrane protein (termed MAS20) which appears to function as a protein import receptor...
  50. pmc Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis
    Sabine Weller
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 76:987-1007. 2005
    ..we made a chimeric protein (PEX26-Mito) with PEX26 as its N-terminus and the targeting segment of a mitochondrial outer membrane protein (OMP25) at its C-terminus...
  51. ncbi Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane
    K Saeki
    Institute of Life Science, Kurume University, 2432 3, Aikawa machi, Kurume 839 0861, Japan
    J Biol Chem 275:31996-2002. 2000
    A mitochondrial outer membrane protein of approximately 22 kDa (1C9-2) was purified from Vero cells assessing immunoreactivity with a monoclonal antibody, and the cDNA was cloned based on the partial amino acid sequence of the trypsin-..
  52. pmc Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation
    Marie Anne Robin
    Department of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Chem 277:40583-93. 2002
    ..S129A mutation resulted in lower affinity for binding to cytoplasmic Hsp70, mitochondrial translocases (TOM40 and TIM44) and reduced mitochondrial import...
  53. ncbi Identification and characterization of Xenopus OMP25
    Masafumi Inui
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8654, Japan
    Dev Growth Differ 46:405-12. 2004
    This study describes the isolation of mitochondrial outer membrane protein 25 (OMP25) from Xenopus laevis and an analysis of its role in early development. X...
  54. pmc ABA, porphyrins and plant TSPO-related protein
    Damien Guillaumot
    Institut des Sciences de la Vie, Molecular Physiology Group FYMO, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Plant Signal Behav 4:1087-90. 2009
    ..of mammalian 18-kDa translocator protein (at least for the mostly studied isoform, 18-kDa TSPO), a mitochondrial outer membrane protein (reviewed in ref. 2)...
  55. pmc Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic tree
    Thomas Cavalier-Smith
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Biol Lett 6:342-5. 2010
    ..The bacteria-like absence of mitochondrial outer-membrane channel Tom40 and DNA replication origin-recognition complexes from trypanosomatid Euglenozoa roots the eukaryotic tree between ..
  56. pmc Genetic variation at a single locus and age of onset for Alzheimer's disease
    Michael W Lutz
    Deane Drug Discovery Institute, Duke University, Durham, NC, USA
    Alzheimers Dement 6:125-31. 2010
    ..finding discussed here is that a variable-length, deoxythymidine homopolymer (poly-T) within intron 6 of the TOMM40 gene is associated with the age of onset of LOAD [Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, ..
  57. pmc Ian4 is required for mitochondrial integrity and T cell survival
    Malini Pandarpurkar
    Department of Medicine and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Suite 218, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:10382-7. 2003
    ..These proteins localize to the outer mitochondrial membrane. Ian4, a mitochondrial outer membrane protein with GTP-binding activity, is normally present in thymocytes, T cells, and B cells...
  58. pmc Structural requirements of Tom40 for assembly into preexisting TOM complexes of mitochondria
    D Rapaport
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Mol Biol Cell 12:1189-98. 2001
    b>Tom40 is the major subunit of the translocase of the outer mitochondrial membrane (the TOM complex)...
  59. pmc Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, Freiburg, Germany
    Mol Biol Cell 21:3106-13. 2010
    The preprotein translocase of the outer mitochondrial membrane (TOM) consists of a central β-barrel channel, Tom40, and six proteins with α-helical transmembrane segments...
  60. pmc Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex
    P J Dekker
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    Mol Cell Biol 18:6515-24. 1998
    ..We have analyzed the molecular architecture of the Tom machinery. The receptor Tom22 stably associates with Tom40, the main component of the GIP, in a complex with a molecular weight of approximately 400,000 ( approximately 400K)..
  61. pmc Protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small tom proteins, and import receptors
    C Meisinger
    , , Germany
    Mol Cell Biol 21:2337-48. 2001
    ..400-kDa (400 K) general import pore (GIP) complex that includes the central receptor Tom22, the channel Tom40, and the three small Tom proteins Tom7, Tom6, and Tom5...
  62. ncbi Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore
    Lars Becker
    Biophysik, Universitat Osnabruck, FB Biologie Chemie, D 49034 Osnabrück, Germany
    J Mol Biol 353:1011-20. 2005
    b>Tom40 is the central pore-forming component of the translocase of the outer mitochondrial membrane (TOM complex)...
  63. ncbi Identification and characterization of a new tom40 isoform, a central component of mitochondrial outer membrane translocase
    Jun Ya Kinoshita
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biochem 141:897-906. 2007
    Newly synthesized precursors are transported into mitochondria through an outer membrane translocase, TOM. Tom40, a central pore-forming component, interacts directly with precursors to help them translocate across the outer membrane...
  64. ncbi Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors
    Thomas Becker
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 283:120-7. 2008
    ..The channel-forming beta-barrel protein Tom40 is targeted to mitochondria via Tom receptors and inserted into the outer membrane by the sorting and assembly ..
  65. doi Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity
    Anna Maria Joseph
    School of Kinesiology and Health Science, York Univesity, Toronto, ON, Canada
    Am J Physiol Cell Physiol 298:C1308-14. 2010
    ..b>Tom40 assembly into the translocases of the outer membrane (TOM complex) was measured in subsarcolemmal mitochondria ..
  66. pmc Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 285:41222-31. 2010
    barrel membrane proteins in the mitochondrial outer membrane use the TOM40 complex to enter mitochondria and then the TOB/SAM complex to be assembled into the outer membrane...
  67. ncbi Protein import into mitochondria of Neurospora crassa
    Holger Prokisch
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstr 5, 81377 Munich, Germany
    Fungal Genet Biol 36:85-90. 2002
    ..receptors which specifically recognize mitochondrial preproteins and a protein conducting channel formed by TOM40. The TOM complex is able to insert resident proteins into the outer membrane and to translocate proteins into the ..
  68. ncbi Tom22', an 8-kDa trans-site receptor in plants and protozoans, is a conserved feature of the TOM complex that appeared early in the evolution of eukaryotes
    Diana Maćasev
    Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Australia
    Mol Biol Evol 21:1557-64. 2004
    ..Comparative sequence analysis suggests three subunits, Tom40, Tom7, and Tom22 as common elements of the protein translocase in the mitochondrial outer membrane in diverse ..
  69. pmc Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Genomics 89:655-65. 2007
    ..SNPs in APOE were further molecularly haplotyped to determine their phases. One set of SNPs in TOMM40, roughly 15 kb upstream of APOE, showed intriguing LD with the epsilon(4) allele and was strongly associated with ..
  70. pmc Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins
    Diana Stojanovski
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, D 79104 Freiburg, Germany
    J Cell Biol 179:881-93. 2007
    ..TOM functions as the central entry gate for nuclear-encoded proteins. The channel-forming Tom40 is a beta-barrel protein, whereas all Tom receptors and small Tom proteins are membrane anchored by a ..
  71. pmc Crystallization and preliminary X-ray diffraction studies of the prototypal homologue of mitoNEET (Tth-NEET0026) from the extreme thermophile Thermus thermophilus HB8
    Asako Kounosu
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:1146-8. 2008
    MitoNEET (a mammalian mitochondrial outer membrane protein) is a potential pharmacological and clinical target of the insulin-sensitizer pioglitazone...
  72. doi N-terminal region of Mannheimia haemolytica leukotoxin serves as a mitochondrial targeting signal in mammalian cells
    Dagmara I Kisiela
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    Cell Microbiol 12:976-87. 2010
    ..By immunoprecipitation we demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin ..
  73. pmc Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa
    Jeremy G Wideman
    Department of Biological Sciences, University of Alberta, Alberta, Canada
    Mol Biol Cell 21:1725-36. 2010
    ..functions including mitochondrial distribution and morphology, assembly of beta-barrel proteins such as Tom40 and porin, association of mitochondria and endoplasmic reticulum, and maintaining lipid composition of ..
  74. doi Mitochondrial preprotein translocase of trypanosomatids has a bacterial origin
    Mascha Pusnik
    Department of Chemistry and Biochemistry, University of Bern, CH 3012 Bern, Switzerland
    Curr Biol 21:1738-43. 2011
    ..b>Tom40, the essential component of the protein translocase of the outer membrane, is conserved in mitochondria of almost ..
  75. pmc Predicting three-dimensional structures of transmembrane domains of β-barrel membrane proteins
    Hammad Naveed
    Department of Bioengineering, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60607, USA
    J Am Chem Soc 134:1775-81. 2012
    ..Such predictions on eukaryotic mitochondria outer membrane protein Tom40 and VDAC are confirmed by independent mutagenesis and chemical cross-linking studies...
  76. doi Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate
    Wen Yan Li
    Department of Biochemistry and Molecular Biology, Zhengzhou University, Zhengzhou City, Henan, People s Republic of China
    Mol Med Rep 5:1396-400. 2012
    ..function, such as nuclear respiratory factor 1 transcript variant 2 (NRF-1-L) and 6 (NRF-1-S), mitochondrial outer membrane protein 40 (Tom40), lipoic acid synthetase (Lias), cytochrome b, medium-chain acyl-coenzyme A dehydrogenase ..
  77. pmc The pathways of mitophagy for quality control and clearance of mitochondria
    G Ashrafi
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
    Cell Death Differ 20:31-42. 2013
    ..In yeast, the mitochondrial outer membrane protein autophagy-related gene 32 (ATG32) recruits the autophagic machinery to mitochondria, while ..
  78. pmc Mitochondrial SKN-1/Nrf mediates a conserved starvation response
    Jennifer Paek
    Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
    Cell Metab 16:526-37. 2012
    ..alleles of skn-1, affecting a domain of SKN-1 that binds the transcription factor MXL-3 and the mitochondrial outer membrane protein PGAM-5...
  79. pmc SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    Akinori Miyashita
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 8:e58618. 2013
    ..Our study highlights the importance of examining associations in multiple ethnic populations...
  80. pmc Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
    Marc A Coram
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 92:904-16. 2013
    ....
  81. pmc The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age
    Beata Ferencz
    Aging Research Center, Karolinska Institutet and Stockholm University Stockholm, Sweden
    Front Hum Neurosci 7:198. 2013
    ..Translocase of outer mitochondrial membrane 40 (TOMM40) may be influential in this regard by influencing mitochondrial neurotoxicity...
  82. pmc Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
    Li Shen
    Center for Neuroimaging and Indiana Alzheimer s Disease Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W 16th Street, Suite 4100, Indianapolis, IN, 46202, USA
    Brain Imaging Behav 8:183-207. 2014
    ..Several other genes (e.g., APOC1, FTO, GRIN2B, MAGI2, and TOMM40) were associated with multiple ADNI phenotypes, warranting further investigation on other data sets...
  83. pmc Association of exome sequences with plasma C-reactive protein levels in >9000 participants
    Ursula M Schick
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 24:559-71. 2015
    ..0 × 10(-8)), we confirmed associations for reported common variants of HNF1A, CRP, IL6R and TOMM40-APOE. In gene-based tests, a burden of rare/lower frequency variation in CRP in EAs (P ≤ 6...
  84. pmc Retro-translocation of mitochondrial intermembrane space proteins
    Piotr Bragoszewski
    Laboratory of Mitochondrial Biogenesis, International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    Proc Natl Acad Sci U S A 112:7713-8. 2015
    ..We identified the general import pore protein Tom40 as an escape gate...
  85. doi The TOM Complex of Amoebozoans: the Cases of the Amoeba Acanthamoeba castellanii and the Slime Mold Dictyostelium discoideum
    Małgorzata Wojtkowska
    Adam Mickiewicz University, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Department of Bioenergetics, Poznan, Poland Electronic address
    Protist 166:349-62. 2015
    ..Our results confirm the presence of Tom70, Tom40 and Tom7 in the A. castellanii and D...
  86. pmc APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds
    Donald M Lyall
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
    Int J Stroke 10:1297-300. 2015
    ..Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease...
  87. pmc Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells
    Girija G Konduri
    Department of Pediatrics, Cardiovascular Research Center and Children s Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin and
    Am J Physiol Lung Cell Mol Physiol 309:L1009-17. 2015
    ..We assessed the effect of O2 and ATP on eNOS interactions with the mitochondrial outer membrane protein porin and with the chaperone hsp90...
  88. doi Molecular architecture of the active mitochondrial protein gate
    Takuya Shiota
    Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Science 349:1544-8. 2015
    ..translocator down to single amino acid residues, revealing different transport paths for preproteins through the Tom40 channel...
  89. pmc Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population
    Qianyi Xiao
    Center for Genomic Translational Medicine and Prevention, School of Public Health, Fudan University, Shanghai, China
    Oncotarget 6:36955-64. 2015
    ..rs9349407 in CD2AP, rs11218343 in SORL1, rs17125944 in FERMT2, rs6859 in PVRL2, rs157580 and rs2075650 in TOMM40. The first three SNPs were associated with SAD risk independent of APOE genotypes...
  90. pmc Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia
    Lee Sooyeon
    Department of Surgery, University of Florida, Gainesville, FL, USA
    Mol Cell Oncol 3:e1087452. 2016
    ..in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and ..
  91. doi Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population
    Ardeshir Omoumi
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurobiol Aging 35:936.e5-12. 2014
    ..no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and ..
  92. ncbi N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence
    Sebastian Maurer-Stroh
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, A 1030, Austria
    J Mol Biol 317:541-57. 2002
    ..4, kinase interacting proteins KIP1/KIP2, protozoan flagellar proteins, homologues of mitochondrial translocase TOM40, of the neuronal calcium sensor NCS-1 and of the cytochrome c-type heme lyase CCHL...
  93. ncbi Biogenesis of yeast mitochondrial cytochrome c: a unique relationship to the TOM machinery
    Nils Wiedemann
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, Hermann Herder Strasse 7, Germany
    J Mol Biol 327:465-74. 2003
    ..When the general import pore (GIP)-protein Tom40 is blocked, the import of cytochrome c is moderately affected...
  94. doi The single mitochondrial porin of Trypanosoma brucei is the main metabolite transporter in the outer mitochondrial membrane
    Mascha Pusnik
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Mol Biol Evol 26:671-80. 2009
    ..conserved metabolite transporter VDAC (voltage dependent anion channel) and the conserved protein import channel Tom40. Bioinformatic searches of the Trypanosoma brucei genome for either VDAC or Tom40 identified a single open reading ..
  95. pmc In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work
    Takuya Shiota
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 108:15179-83. 2011
    ..Here we analyze the interactions of Tom22, a multifunctional subunit of the outer membrane translocator TOM40 complex, with other translocator subunits such as Tom20, Tom40, and Tim50 and with substrate precursor proteins at ..
  96. pmc Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40
    Anton Kuzmenko
    University of Tartu, Institute of Technology, Tartu, Estonia
    Sci Rep 1:195. 2011
    b>Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import...
  97. ncbi Crystallization and preliminary crystallographic analysis of rat monoamine oxidase A complexed with clorgyline
    Jichun Ma
    Institute for Protein Research, Osaka University, Japan
    Acta Crystallogr D Biol Crystallogr 60:317-9. 2004
    ..Diffraction data were collected to 3.2 A resolution. The crystal belongs to the space group P4(3)2(1)2, with unit-cell parameters a = b = 158.2, c = 258.4 A...
  98. ncbi Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway
    Nils Wiedemann
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 279:18188-94. 2004
    b>Tom40 forms the central channel of the preprotein translocase of the mitochondrial outer membrane (TOM complex)...
  99. ncbi Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability
    Dusanka Milenkovic
    Institut fur Biochemie und Molekularbiologie, Universitat Freiburg, D 79104 Freiburg, Germany
    J Biol Chem 279:22781-5. 2004
    ..Here we report the identification of Sam35, the first peripheral mitochondrial outer membrane protein that is essential for cell viability...
  100. ncbi Membrane-embedded C-terminal segment of rat mitochondrial TOM40 constitutes protein-conducting pore with enriched beta-structure
    Hiroyuki Suzuki
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 279:50619-29. 2004
    b>TOM40 is the central component of the preprotein translocase of the mitochondrial outer membrane (TOM complex)...
  101. pmc Functions of the small proteins in the TOM complex of Neurospora crasssa
    E Laura Sherman
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Mol Biol Cell 16:4172-82. 2005
    ..Newly imported Tom40 was readily assembled into the TOM complex in mitochondria lacking any of the small Tom proteins.

Research Grants23

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..to ATP, a NOS agonist, and postnatal oxygen tension stimulate the association of eNOS with the mitochondrial outer membrane protein, porin in normal fetal lamb pulmonary artery endothelial cells (PAEC)...
  2. UNDERSTANDING THE ROLE OF MITOCHONDRIAL IMPORT IN AMYOTROPHIC LATERAL SCLEROSIS
    Matthew Crisp; Fiscal Year: 2013
    ..by increased levels of the translocase of the outer mitochondrial membrane (TOM) proteins TOM20, TOM22, and TOM40, which are three core components of the machinery responsible for the import of nearly all nuclear-encoded ..
  3. Robyn A Honea; Fiscal Year: 2015
    ..interactions, we have identified several candidate genes associated with AD risk (BDNF, APOE, CLU, PICALM, CR1, TOMM40) 21, 22, and will take them through a three-step process...
  4. Genetic Factors that Impact the Risk of Alzheimer's Disease
    Allen D Roses; Fiscal Year: 2010
    ..results show that age of onset of AD is a function of at least two pathogenesis specific genes APOE and TOMM40, each with multiple determinants that affect their protein-protein interactions, residing on the same linkage ..
  5. A Study of APOE and TOMM40 in a large Cerebral Palsy Registry
    James A Blackman; Fiscal Year: 2010
    ..In the most innovative aspect of this project, we will also explore the role of APOE regulatory genes, including TOMM40, in cerebral palsy severity...
  6. ORNIT FALEK; Fiscal Year: 2016
    ..by applicant): We have demonstrated that there is a strong association between polymorphic poly-T variant of TOMM40 and the age of onset of late-onset Alzheimer's disease (AD)...
  7. MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMES
    Minu Chaudhuri; Fiscal Year: 2002
    ..expressed during the parasite life cycle; 2) to clone and characterize components of the TOM complex (TOM70, TOM40, TOM22, and TOM20) from T...
  8. Novel intervention strategy for mitochondrial ROS toxicity
    Yisang Yoon; Fiscal Year: 2006
    ..Conversely, inhibition of mitochondrial fission prevents apoptotic progression. The mitochondrial outer membrane protein hFis1 recruits the membrane severing protein DLP1 to mediate mitochondrial fission...
  9. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..
  10. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2006
    ..S. whites and blacks. The proposed immunochemical, functional, molecular and genetic epidemiological studies will enable us to delineate the role of the apoD in the etiology of AD. ..
  11. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2006
    ..We will systematically screen the three PON genes for new mutations (Aim 1) and, in conjunction with known PON potymorphisms, we will evaluate their genetic and functional significances (Aims 2-4). ..
  12. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Microarrays for Alzheimer's Disease Mouse Models
    P Reddy; Fiscal Year: 2003
    ..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
  14. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..The proposed studies will clarify biological mechanisms relating variations in estrogen to the development of AD. ..
  15. Genetic Determinants of HDL-Cholesterol
    M Ilyas Kamboh; Fiscal Year: 2010
    ..As a result of these analyses, we should be able to definitively determine both rare and common variants that contribute to high and low HDL-C levels. ..
  16. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2006
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  17. Vascular Risk Factors in Alzheimer's Disease
    Gail Li; Fiscal Year: 2006
    ..abstract_text> ..
  18. Prothrombin Gene Variation and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2010
    ....
  19. RNAi screen to identify host factors involved in Chlamydia pathogenesis
    Isabelle Derre; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  20. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
  21. APOE Gene-Based Haplotype Study in Alzeheimer's Disease
    Chang En Yu; Fiscal Year: 2005
    ..2. Analyze the association between APOE haplotypes and AD. 3. Establish association between APOE expression level and haplotypes. 4. Identify critical SNPs from candidate haplotypes that affect APOE expression. ..
  22. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..