TNNT2

Summary

Gene Symbol: TNNT2
Description: troponin T2, cardiac type
Alias: CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, troponin T, cardiac muscle, cardiomyopathy, dilated 1D (autosomal dominant), cardiomyopathy, hypertrophic 2, troponin T type 2 (cardiac), truncated cardiac troponin T
Species: human

Top Publications

  1. ncbi Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy
    H Watkins
    Howard Hughes Medical Institute, Boston, MA
    N Engl J Med 332:1058-64. 1995
  2. ncbi Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q
    P J Townsend
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, London, United Kingdom
    Genomics 21:311-6. 1994
  3. ncbi Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere
    L Thierfelder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 77:701-12. 1994
  4. ncbi Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy
    J F Forissier
    Unité de Recherches 153 de l INSERM, Paris, France
    Circulation 94:3069-73. 1996
  5. ncbi Sudden death due to troponin T mutations
    J C Moolman
    University of Stellenbosch, Tygerberg, Republic of South Africa
    J Am Coll Cardiol 29:549-55. 1997
  6. ncbi Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy
    C Nakajima-Taniguchi
    Department of Medicine III, Osaka University Medical School, Japan
    J Mol Cell Cardiol 29:839-43. 1997
  7. ncbi Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis
    R Anan
    First Department of Medicine, Kagoshima University, Sakuragaoka, Japan
    Circulation 98:391-7. 1998
  8. ncbi Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, CT, USA
    Clin Chim Acta 284:161-74. 1999
  9. ncbi Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein
    C Redwood
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circ Res 86:1146-52. 2000
  10. ncbi Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy
    C Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Circulation 102:1950-5. 2000

Research Grants

  1. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2011
  2. Jian Ping Jin; Fiscal Year: 2014
  3. Jose Renato Pinto; Fiscal Year: 2014
  4. Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament Activation
    Murali Chandra; Fiscal Year: 2012
  5. Structural Mechanisms Modulating Contraction in Normal and Diseased Heart
    Paul R Rosevear; Fiscal Year: 2010
  6. FHC Tn Mutations: Functional Consequences & Mechanisms
    James Potter; Fiscal Year: 2005
  7. CARDIAC MUSCLE--MOLECULAR MECHANISMS OF REGULATION
    JOHN PUTKEY; Fiscal Year: 2000
  8. REGULATION OF CARDIAC CROSS-BRIDGES BY TROPONIN T
    SCOTT BUCK; Fiscal Year: 2004
  9. High sensitivity Troponin T as a novel predictor of cardiovascular events
    ALEXIS LYNN BEATTY; Fiscal Year: 2012
  10. ALDRIN VERNO GOMES; Fiscal Year: 2014

Detail Information

Publications219 found, 100 shown here

  1. ncbi Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy
    H Watkins
    Howard Hughes Medical Institute, Boston, MA
    N Engl J Med 332:1058-64. 1995
    ..It is not known how often the disease is caused by mutations in the tropomyosin and troponin genes, and the associated clinical phenotypes have not been carefully studied...
  2. ncbi Human cardiac troponin T: identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q
    P J Townsend
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, London, United Kingdom
    Genomics 21:311-6. 1994
    ..Hybridization of the cloned cDNAs to genomic DNA identifies a single-copy gene, and using somatic cell hybrid analysis, we have mapped the corresponding gene locus (designated TNNT2) to the long arm of chromosome 1 (1cen-qter).
  3. ncbi Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere
    L Thierfelder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 77:701-12. 1994
    ..Further, because the splice site mutation is predicted to function as a null allele, we suggest that abnormal stoichiometry of sarcomeric proteins can cause cardiac hypertrophy...
  4. ncbi Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy
    J F Forissier
    Unité de Recherches 153 de l INSERM, Paris, France
    Circulation 94:3069-73. 1996
    ..In some families, the disease is linked to the CMH2 locus on chromosome 1q3, in which the cardiac troponin T gene (TNNT2) has been identified as the disease gene...
  5. ncbi Sudden death due to troponin T mutations
    J C Moolman
    University of Stellenbosch, Tygerberg, Republic of South Africa
    J Am Coll Cardiol 29:549-55. 1997
    ..This study was designed to verify initial observations of the clinical and prognostic features of hypertrophic cardiomyopathy caused by cardiac tropnin T gene mutations...
  6. ncbi Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy
    C Nakajima-Taniguchi
    Department of Medicine III, Osaka University Medical School, Japan
    J Mol Cell Cardiol 29:839-43. 1997
    ..for HCM in HCM families have been identified as beta-myosin heavy chain, alpha-tropomyosin, cardiac troponin T (cTnT) and myosin binding protein-C genes...
  7. ncbi Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis
    R Anan
    First Department of Medicine, Kagoshima University, Sakuragaoka, Japan
    Circulation 98:391-7. 1998
    ..Patients with mutations in the cardiac troponin T (cTnT) gene have particularly poor prognosis but only mild hypertrophy...
  8. ncbi Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, CT, USA
    Clin Chim Acta 284:161-74. 1999
    ..Jeopardized myocardial tissue can recover with acute recanalization. Support for this model comes from clinical observations and animal studies...
  9. ncbi Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein
    C Redwood
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circ Res 86:1146-52. 2000
    ..Further, these findings underscore the importance of studying mixed mutant:wild-type preparations to faithfully model this autosomal-dominant disease...
  10. ncbi Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy
    C Y Ho
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Circulation 102:1950-5. 2000
    Mutations in the gene that encode cardiac troponin T (cTnT) account for approximately 15% of cases of familial hypertrophic cardiomyopathy (HCM)...
  11. ncbi Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy
    M Kamisago
    Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA
    N Engl J Med 343:1688-96. 2000
    ..To elucidate this important cause of heart failure, we investigated other genetic causes of dilated cardiomyopathy...
  12. ncbi Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy
    D Li
    Section of Cardiology, Baylor College of Medicine, M D Anderson Cancer Center, Houston, Texas, USA
    Circulation 104:2188-93. 2001
    ..Studies indicate that mutations in sarcomeric proteins are responsible for FHCM and suggest that mutations in cytoskeletal proteins cause FDCM. Evidence is evolving, however, that such conclusions are premature...
  13. ncbi Prevalence and age-dependence of malignant mutations in the beta-myosin heavy chain and troponin T genes in hypertrophic cardiomyopathy: a comprehensive outpatient perspective
    Michael J Ackerman
    Department of Internal Medicine Division of Cardiovascular Diseases, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 39:2042-8. 2002
    ..The goal of this study was to determine the prevalence of "malignant" mutations in hypertrophic cardiomyopathy (HCM)...
  14. ncbi Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy
    Paul Robinson
    Department of Cardiovascular Medicine, Wellcome Trust Center for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Biol Chem 277:40710-6. 2002
    ..The functional consequences of this DCM mutation are qualitatively different from the R92Q or any other studied HCM troponin T mutation, suggesting that DCM and HCM may be triggered by distinct primary stimuli...
  15. ncbi Prevalence and severity of "benign" mutations in the beta-myosin heavy chain, cardiac troponin T, and alpha-tropomyosin genes in hypertrophic cardiomyopathy
    Sara L Van Driest
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 106:3085-90. 2002
    ..survival: N232S, G256E, F513C, V606M, R719Q, and L908V of beta-myosin heavy chain (MYH7); S179F of troponin T (TNNT2); and D175N of alpha-tropomyosin (TPM1)...
  16. ncbi Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy
    Pascale Richard
    UF de Cardiogénétique et Myogénétique, Service de Biochimie B, Hopital de la Salpetriere, 47 Bld de l Hopital, 75651 Paris Cedex 13, France
    Circulation 107:2227-32. 2003
    ..The aim of the present study was to perform a systematic screening of these genes in a large population, to evaluate the distribution of the disease genes, and to determine the best molecular strategy in clinical practice...
  17. ncbi Hypertrophic cardiomyopathy: low frequency of mutations in the beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes among Spanish patients
    Monica Garcia-Castro
    Genética Molecular Instituto de Investigación Nefrológica IRSIN FRIAT and Servicio de Cardiología, Hospital Central de Asturias, 33006 Oviedo, Spain
    Clin Chem 49:1279-85. 2003
    Mutations in the cardiac beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes are reportedly responsible for up to 40% of familial cases with hypertrophic cardiomyopathy (HC)...
  18. ncbi Different functional properties of troponin T mutants that cause dilated cardiomyopathy
    Gayathri Venkatraman
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33101, USA
    J Biol Chem 278:41670-6. 2003
    ..These results suggest that a rightward shift in Ca2+ sensitivity is not the only determinant for the phenotype of DCM...
  19. ncbi Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy
    J Erdmann
    Department of Internal Medicine II Cardiology, University of Regensburg, Regensburg, Germany
    Clin Genet 64:339-49. 2003
    ..HCM patients for mutations in six sarcomeric genes: myosin-binding protein C3 (MYBPC3), MYH7, cardiac troponin T (TNNT2), alpha-tropomyosin (TPM1), cardiac troponin I (TNNI3), and cardiac troponin C (TNNC1)...
  20. ncbi Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contraction
    Keita Harada
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 279:14488-95. 2004
    ..These results suggest that different regions of TnT may contribute to the pathogenesis of TnT-linked FHC through different mechanisms...
  21. ncbi The role of a common TNNT2 polymorphism in cardiac hypertrophy
    Kazuo Komamura
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Hum Genet 49:129-33. 2004
    We found a five-basepair insertion/deletion polymorphism in intron 3 of TNNT2, one of the genes responsible for hypertrophic cardiomyopathy...
  22. ncbi Role of troponin T in disease
    Aldrin V Gomes
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Mol Cell Biochem 263:115-29. 2004
    ..To date 30 mutations have been identified in the cardiac TnT (CTnT) gene that results in familial HCM (FHC)...
  23. ncbi Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy
    Jens Mogensen
    Department of Cardiological Sciences, St George s Hospital Medical School, London, United Kingdom
    J Am Coll Cardiol 44:2033-40. 2004
    We performed genetic investigations of cardiac troponin T (TNNT2) and troponin C (TNNC1) in 235 consecutive patients with idiopathic dilated cardiomyopathy (DCM) to evaluate prevalence of mutations and associated disease expression in ..
  24. ncbi Mutations profile in Chinese patients with hypertrophic cardiomyopathy
    Lei Song
    Sino German Laboratory for Molecular Medicine, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Clin Chim Acta 351:209-16. 2005
    ..There are more than 1 million patients with hypertrophic cardiomyopathy (HCM) in China, but the genetic basis is presently unknown...
  25. ncbi Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype
    Mahmooda Mirza
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 280:28498-506. 2005
    ....
  26. ncbi F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers
    Olga M Hernandez
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 280:37183-94. 2005
    ..The combination of increased Ca(2+) sensitivity and energy cost in the F110I hearts may be responsible for the greater severity of this phenotype compared with the R278C mutation...
  27. pmc Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling
    J Ingles
    J Med Genet 42:e59. 2005
    ..To report the frequency of single and multiple gene mutations in an Australian cohort of patients with hypertrophic cardiomyopathy (HCM)...
  28. ncbi Troponin T and beta-myosin mutations have distinct cardiac functional effects in hypertrophic cardiomyopathy patients without hypertrophy
    Miriam Revera
    Department of Cardiology, IRCCS San Matteo Hospital, Pavia, Italy
    Cardiovasc Res 77:687-94. 2008
    ..The aims of this study were to investigate whether distinct HCM-mutations have different consequences for cardiac structure and function in the absence of the confounding effects of hypertrophy...
  29. ncbi A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin
    Jose R Pinto
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 283:2156-66. 2008
    ..We are reporting the functional effects of the first cardiac troponin T (CTnT) mutation linked to infantile RCM resulting from a de novo deletion mutation of glutamic acid 96...
  30. ncbi Troponin T elevation and long-term mortality after chronic obstructive pulmonary disease exacerbation
    P H Brekke
    Dept of Medicine Akershus University Hospital, N 1478 Lørenskog, Norway
    Eur Respir J 31:563-70. 2008
    ..Median observation time was 1.9 yrs. In 396 patients, measurements of cardiac-specific troponin T (cTnT) were available. Levels of cTnT >/=0.04 mug.L(-1) were considered elevated...
  31. pmc Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients
    Sangeetha Satyan
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 50:1009-19. 2007
    Although the cardiac biomarker troponin T (cTnT) is related strongly to mortality in patients with end-stage renal disease, the independent association of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and cTnT levels in ..
  32. pmc Cardiac troponin T mutation in familial cardiomyopathy with variable remodeling and restrictive physiology
    S C Menon
    Department of Pediatric and Adolescent Medicine, Division of Cardiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Clin Genet 74:445-54. 2008
    ..Linkage to eight genes was excluded, but a cardiac troponin T (TNNT2) marker cosegregated with the disease phenotype...
  33. pmc Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 2:306-13. 2009
    ..This is critically important as genetic DCM, usually presenting with advanced, life-threatening disease, may be preventable with early intervention in relatives known to carry the mutation...
  34. doi Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation
    Mark Luedde
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Cardiovasc Res 86:452-60. 2010
    ..Here, we describe a family with LVNC due to a novel missense mutation, pE96K, in the cardiac troponin T gene (TNNT2).
  35. doi The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T
    Eduard M Laufer
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1269-75. 2010
    This study explored the relationship between coronary atherosclerotic plaque burden and quantifiable circulating levels of troponin measured with a recently introduced high sensitive cardiac troponin T (hs-cTnT) assay.
  36. doi Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations
    Francesca Girolami
    Unit for Genetic Diagnosis, Careggi University Hospital, Florence, Italy
    J Am Coll Cardiol 55:1444-53. 2010
    ..The aim of this study was to describe the clinical profile associated with triple sarcomere gene mutations in a large hypertrophic cardiomyopathy (HCM) cohort...
  37. pmc Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study
    Justin T Saunders
    6565 Fannin, MS A 601, Houston, TX 77030, USA
    Circulation 123:1367-76. 2011
    We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of ..
  38. doi 72-h kinetics of high-sensitive troponin T and inflammatory markers after marathon
    Johannes Scherr
    Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany
    Med Sci Sports Exerc 43:1819-27. 2011
    ..However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction...
  39. doi Cardiac Troponin T (TNNT2) mutations are less prevalent in Indian hypertrophic cardiomyopathy patients
    Deepa Selvi Rani
    CSIR Centre for Cellular and Molecular Biology, Hyderabad, India
    DNA Cell Biol 31:616-24. 2012
    We sought to determine the frequency of the genetic variations in the Troponin T (TNNT2) gene and its association in Indian cardiomyopathy patients...
  40. doi Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene
    Ferdinando Pasquale
    Heart Hospital, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
    Circ Cardiovasc Genet 5:10-7. 2012
    Hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene (TNNT2) has been associated with a high risk of sudden cardiac death (SCD) and mild left ventricular hypertrophy...
  41. doi Utility of 14 novel biomarkers in patients with acute chest pain and undetectable levels of conventional cardiac troponin
    Christophe Meune
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Int J Cardiol 167:1164-9. 2013
    ..The aim of this multicenter study was to determine the accuracy of multiple biomarkers in these patients...
  42. doi High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease
    Philip Haaf
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Circulation 126:31-40. 2012
    ..We hypothesized that high-sensitivity cardiac troponin (hs-cTn) and its early change are useful in distinguishing acute myocardial infarction (AMI) from acute cardiac noncoronary artery disease...
  43. pmc Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates
    Bin Liu
    Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e38259. 2012
    ..Troponin C may act as a hub, sensing physiological and pathological stimuli to modulate the Ca(2+)-binding properties of the thin filament and influence the contractile performance of the heart...
  44. pmc Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients
    Tobias Breidthardt
    School of Graduate Entry Medicine and Health, University of Nottingham Medical School at Derby and Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom
    Clin J Am Soc Nephrol 7:1285-92. 2012
    ..Circulating troponin T levels are frequently elevated in patients undergoing long-term dialysis. The pathophysiology underlying these elevations is controversial...
  45. pmc Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy
    D S Lim
    Section of Cardiology, Department of Medicine, Section of Cardiovascular Sciences and DeBakey Heart Center, Baylor College of Medicine, Houston, Texas, USA
    Circulation 103:789-91. 2001
    ..METHODS AND RESULTS: We randomized 24 adult cardiac troponin T (cTnT-Q(92)) mice, which exhibit myocyte disarray and interstitial fibrosis, to treatment with losartan or placebo and ..
  46. pmc Evaluating a new graphical ordinal logit method (GOLDminer) in the diagnosis of myocardial infarction utilizing clinical features and laboratory data
    L H Bernstein
    Department of Pathology and Laboratory Medicine, Yale University School of Medicine, Bridgeport Hospital, Connecticut 06610, USA
    Yale J Biol Med 72:259-68. 1999
    OBJECTIVE: We used a new graphical ordinal logit method (GOLDminer) to assess a single cardiac troponin T (cTnT) analysis at the time of admission (first generation monoclonal; Roche BMC Corp...
  47. ncbi Patterns and diagnostic value of cardiac troponin I vs. troponin T and CKMB after OPCAB surgery
    A A Peivandi
    Department for Cardiothoracic Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Thorac Cardiovasc Surg 49:137-43. 2001
    ..this prospective study was to determine the patterns and kinetic and diagnostic value of cTnI, cardiac troponin T (cTnT), and creatine kinase MB (CKMB) activity after minimally invasive coronary revascularization using an octopus ..
  48. ncbi Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocyte contractility
    A J Marian
    Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    Circ Res 81:76-85. 1997
    ..To test this hypothesis, we determined the impact of expression of a mutant (Arg92Gln) human cardiac troponin T (cTnT), known to cause HCM in humans, on adult cardiac myocyte contractility...
  49. ncbi Results from a multicenter evaluation of the 4th generation Elecsys Troponin T assay
    D Hermsen
    Institute of Clinical Chemistry and Laboratorv Diagnostics, Heinrich Heine University, Dusseldorf, Germany
    Clin Lab 53:1-9. 2007
    ..heparin plasma samples have been described for many commercial troponin assays including the cardiac troponin T (cTnT) assay...
  50. ncbi Troponin I, troponin T, CKMB-activity and CKMB-mass as markers for the detection of myocardial contusion in patients who experienced blunt trauma
    J C Swaanenburg
    Central Clinical Chemical Laboratory, University Hospital Groningen, The Netherlands
    Clin Chim Acta 272:171-81. 1998
    ..We investigated the assessment of the new cardiac markers troponin I (cTnI) and troponin T (cTnT) in relation to the conventional CKMB-activity, the CKMB-activity/CK-total ratio, CKMB-mass and the CKMB-mass/CK-..
  51. ncbi A new sensitive cardiac Troponin T rapid test (TROPT) for the detection of experimental acute myocardial damage in rats
    T Bertsch
    Institute for Clinical Chemistry, Faculty of Clinical Medicine Mannheim of the University of Heidelberg, Germany
    Exp Toxicol Pathol 51:565-9. 1999
    Cardiac Troponin T (cTnT) is a cardiac structural protein which is released in the circulation during myocardial cell damage...
  52. ncbi Prognostic value of troponin T and homocysteine in patients with end-stage renal disease
    Asife Sahinarslan
    Department of Cardiology, Medicine Faculty of Gazi University, Ankara, Turkey
    Turk Kardiyol Dern Ars 36:382-7. 2008
    The most important cause of increased mortality in end-stage renal disease (ESRD) is cardiovascular diseases. We investigated the prognostic value of cardiac troponin T (cTnT) and homocysteine in the long-term follow-up of ESRD patients.
  53. doi Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays
    Alma Mingels
    Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Chem 55:101-8. 2009
    ..The application of recently developed highly sensitive cTn immunoassays may help resolve these problems...
  54. pmc Mutual rescues between two dominant negative mutations in cardiac troponin I and cardiac troponin T
    Bin Wei
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 285:27806-16. 2010
    ..helix of cardiac TnI (cTnI) in wild turkey hearts in concurrence with an abnormally spliced myopathic cardiac TnT (cTnT) (Biesiadecki, B. J., Schneider, K. L., Yu, Z. B., Chong, S. M., and Jin, J. P. (2004) J. Biol. Chem...
  55. pmc Diagnosis of myocardial infarction: integration of serum markers and clinical descriptors using information theory
    L H Bernstein
    Department of Pathology and Laboratory Medicine, Bridgeport Hospital, Connecticut 06610, USA
    Yale J Biol Med 72:5-13. 1999
    We examine the use of information theory applied to a single cardiac troponin T (cTnT) (first generation monoclonal; Boehringer Mannheim Corp...
  56. ncbi Cardiac troponin T vs other biochemical markers in patients with congestive heart failure
    Yukiko Nishio
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ J 71:631-5. 2007
    ..Cardiac troponin T (cTnT), a specific and sensitive marker of myocardial injury, has been related to long-term outcome in patients with CHF, ..
  57. ncbi Combined utility of brain natriuretic peptide and cardiac troponin T may improve rapid triage and risk stratification in normotensive patients with pulmonary embolism
    Igor I Tulevski
    Department of Cardiology, Academic Medical Center, Amsterdam, 1100 DD, The Netherlands
    Int J Cardiol 116:161-6. 2007
    Evaluation of the combined utility of brain natriuretic peptide (BNP) and cardiac troponin T (cTnT) for risk stratification in normotensive patients with acute pulmonary embolism...
  58. ncbi Sustained elevated concentrations of cardiac troponin T during acute allograft rejection after heart transplantation in children
    Håkan Wåhlander
    Department of Pediatrics, Division of Cardiology, The Queen Silvia Children s Hospital, SU Ostra, SE 416 85 Goteborg, Sweden
    Transplantation 74:1130-5. 2002
    ..We evaluated the myocardial damage marker cardiac troponin T (cTnT) as a marker of rejection in children who have undergone heart transplantation.
  59. ncbi Effect of patent ductus arteriosus and indomethacin treatment on serum cardiac troponin T levels in preterm infants with respiratory distress syndrome
    D Trevisanuto
    Department of Pediatrics, University of Padova, Italy
    Eur J Pediatr 159:273-6. 2000
    Cardiac troponin T (cTnT) represents a sensitive and specific marker of ischemic myocardial damage in adult and neonatal populations...
  60. ncbi [Plasma levels of troponin T in rabbits after administration of new antineoplastic agents (Oracin and Dimefluron) and daunorubicin]
    M Adamcova
    Univerzita Karlova v Praze, Lekarska fakulta v Hradci Kralove
    Acta Medica (Hradec Kralove) Suppl 44:3-8. 2001
    Recently, cardiac troponin T (cTnT) has been shown to be a sensitive marker of anthracycline-induced cardiomyopathy. In our study, the cardiotoxicity of repeated i.v...
  61. ncbi Timing of peak troponin T and creatine kinase-MB elevations after percutaneous coronary intervention
    Wayne L Miller
    Cardiovascular Division, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Chest 125:275-80. 2004
    The prognostic significance of elevations in creatine kinase-MB and troponin T (cTnT), which have been conventionally measured 6 to 8 h after percutaneous coronary intervention (PCI), has been established...
  62. pmc Troponin T measurement can predict persistent left ventricular dysfunction in peripartum cardiomyopathy
    C L Hu
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuchang District, Wuhan, People s Republic of China
    Heart 93:488-90. 2007
    To determine whether measurement of cardiac troponin T (cTnT) concentration in newly diagnosed peripartum cardiomyopathy (PPCM) can be used to predict persistent left ventricular dysfunction after a 6-month follow-up.
  63. ncbi The influence of chest compressions and external defibrillation on the release of creatine kinase-MB and cardiac troponin T in patients resuscitated from out-of-hospital cardiac arrest
    M Mullner
    Department of Emergency Medicine, Vienna General Hospital, University of Vienna, Medical School, Austria
    Resuscitation 38:99-105. 1998
    This study sought to determine the influence of resuscitative procedures, such as chest compressions and external defibrillation, on the release of creatine kinase (CK)-MB and cardiac troponin T (cTnT).
  64. ncbi Cardiac troponin T as a marker of myocardial damage caused by antineoplastic drugs in rabbits
    M Adamcova
    Department of Physiology, Charles University Faculty of Medicine in Hradec Kralove, Czech Republic
    J Cancer Res Clin Oncol 125:268-74. 1999
    ..of antineoplastic drugs were investigated in rabbits in vivo from the viewpoint of release of cardiac troponin T (cTnT) measured by Elecsys Troponin T STAT immunoassay (Boehringer Mannheim, Germany)...
  65. ncbi Cardiac troponin T and I and creatine kinase-MB as markers of myocardial injury and predictors of outcome following percutaneous coronary intervention
    Thuraia Nageh
    King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Int J Cardiol 92:285-93. 2003
    ....
  66. doi Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infants
    Afif F El-Khuffash
    Department of Neonatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 96:F133-7. 2011
    ..The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) in combination with echocardiography assessment may facilitate the development of ..
  67. ncbi Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy
    Tomas Simunek
    Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    Cancer Chemother Pharmacol 52:431-4. 2003
    Cardiac troponin T (cTnT) plasma concentration is considered a useful marker of anthracycline-induced cardiomyopathy...
  68. ncbi Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice
    Christian Löwbeer
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Clin Chim Acta 344:73-8. 2004
    The isolated perfused mouse heart is a useful experimental model, and cardiac troponin T (cTnT) in coronary effluent may be a sensitive marker of myocardial damage...
  69. ncbi Cardiac troponin T in patients with clinically suspected myocarditis
    B Lauer
    Herzzentrum Leipzig, Universitätsklinik für Kardiologie, Leipzig, Germany
    J Am Coll Cardiol 30:1354-9. 1997
    ..whether myocyte injury can be assessed sensitively by measurement of serum levels of cardiac troponin T (cTnT) in patients with clinically suspected myocarditis and whether cTnT levels may predict the results of histologic ..
  70. ncbi Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes
    C R deFilippi
    Department of Internal Medicine, University of Texas Medical Branch at Galveston, USA
    J Am Coll Cardiol 35:1827-34. 2000
    We prospectively evaluated the relation between cardiac troponin T (cTnT) level, the presence and severity of coronary artery disease (CAD) and long-term prognosis in patients with chest pain but no ischemic electrocardiographic (ECG) ..
  71. ncbi Cardiac troponin T: a marker in the diagnosis of acute myocarditis in children
    J Soongswang
    Department of Pediatrics, Siriraj Hospital, Faculty of Medicine, Mahidol University, 2 Prannok Road, Bangkok, 10700, Thailand
    Pediatr Cardiol 26:45-9. 2005
    This study was conducted to assess the use of serum cardiac troponin T (cTnT) level as a noninvasive indicator to diagnose acute myocarditis in children...
  72. pmc The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy
    Ferhaan Ahmad
    Cardiovascular Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 3:e2642. 2008
    ..and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2)...
  73. ncbi Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon
    N Rifai
    Department of Laboratory Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 83:1085-9. 1999
    Cardiac troponin T (cTnT) and troponin I (cTnI) are highly sensitive and specific for detecting myocardial damage even in the presence of skeletal muscle injury...
  74. ncbi Cardiac troponin T levels are associated with poor short- and long-term prognosis in patients with acute cardiogenic pulmonary edema
    Eduardo Roque Perna
    Coronary Intensive Care Unit, Instituto de Cardiologia Juana F Cabral, Corrientes, Argentina
    Am Heart J 143:814-20. 2002
    The clinical determinants of increased cardiac troponin T (cTnT) in patients with acute cardiogenic pulmonary edema are not well defined, and the ability of this marker to predict long-term mortality has not yet been documented.
  75. ncbi Cardiac troponin T and C-reactive protein for predicting prognosis, coronary atherosclerosis, and cardiomyopathy in patients undergoing long-term hemodialysis
    Christopher deFilippi
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    JAMA 290:353-9. 2003
    Cardiac troponin T (cTnT) and C-reactive protein (CRP) are prognostic markers in acute coronary syndromes...
  76. ncbi Dobutamine stress echocardiography and cardiac troponin T for the detection of significant coronary artery disease and predicting outcome in renal transplant candidates
    R Sharma
    Department of Cardiology, St George s Hospital, London, UK
    Eur J Echocardiogr 6:327-35. 2005
    ..assess the diagnostic accuracy of dobutamine stress echocardiography (DSE) and baseline plasma cardiac troponin T (cTnT) for detecting significant CAD and predicting adverse cardiac events in patients referred for renal transplantation.
  77. pmc Troponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle
    Murali Chandra
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, 99164 6520, USA
    Biophys J 90:2867-76. 2006
    ..Dynamic features of rat cardiac TnT (cTnT) and rat fast skeletal TnT (fsTnT) reconstituted cardiac muscle preparations were captured by fitting the force ..
  78. ncbi Elevated cardiac troponin T is associated with increased left ventricular mass index and predicts mortality in continuous ambulatory peritoneal dialysis patients
    Dursun Duman
    Haydarpasa Numune Training and Research Hospital, Department of Cardiology, Ahmet Refik Sok Ceylan Apt 19 5, Ciftehavuzlar, 81060 Istanbul, Turkey
    Nephrol Dial Transplant 20:962-7. 2005
    ..Elevated cardiac troponin T (cTnT) is related to increased left ventricular mass index (LVMI) and predicts poor outcome in chronic haemodialysis ..
  79. ncbi Importance of early combined N-terminal pro-brain natriuretic peptide and cardiac troponin T measurements for long-term risk stratification of patients with decompensated heart failure
    Eduardo R Perna
    Heart Failure Clinic, Instituto de Cardiologia J F Cabral, Corrientes, Argentina
    J Heart Lung Transplant 25:1230-40. 2006
    ..We prospectively studied the optimal timing of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements for long-term risk stratification.
  80. ncbi Exercise-induced cardiac troponin T release: a meta-analysis
    Robert Shave
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, United Kingdom
    Med Sci Sports Exerc 39:2099-106. 2007
    Cardiac troponin T (cTnT) is a highly specific marker of myocardial damage and used clinically in the diagnosis of acute myocardial infarction (AMI). Release of cTnT has been demonstrated in several small studies after endurance exercise...
  81. doi Long-term survival and cardiac troponin T elevation in on- and off-pump coronary artery bypass surgery
    Jeremiah R Brown
    The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire 03756, USA
    Heart Surg Forum 11:E163-8. 2008
    ..Long-term survival and elevation in cardiac troponin T (cTnT) concentration following CCAB and OPCAB have not been assessed...
  82. ncbi Prognostic value of serum concentration of heart-type fatty acid-binding protein relative to cardiac troponin T on admission in the early hours of acute coronary syndrome
    Junnichi Ishii
    Division of Critical Care, Fujita Health University Graduate School of Health Sciences, Toyoake, Japan
    Clin Chem 51:1397-404. 2005
    ..We evaluated the prognostic value of the H-FABP concentration relative to cardiac troponin T (cTnT) in the early hours of ACS.
  83. ncbi Elevated cardiac troponin T in predialysis patients is associated with inflammation and predicts mortality
    C Löwbeer
    Division of Clinical Chemistry, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    J Intern Med 253:153-60. 2003
    Cardiac troponin T (cTnT) is a highly sensitive and specific marker of myocardial damage. It has been shown that elevated serum concentrations of cTnT in haemodialysis (HD) patients are associated with poor prognostic outcome...
  84. ncbi C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction
    D A Morrow
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 31:1460-5. 1998
    ..evaluated C-reactive protein (CRP) alone and in conjunction with a rapid qualitative assay for cardiac-specific troponin T (cTnT) for predicting 14-day mortality in patients with unstable angina or non-Q wave myocardial infarction (NQMI).
  85. ncbi Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes. The GUSTO-IIa Investigators
    L K Newby
    Duke Clinical Research Institute, Durham, NC, USA
    Circulation 98:1853-9. 1998
    The baseline cardiac troponin T (cTnT) level strongly predicts short-term mortality in acute coronary syndromes, but the added value of later measures to predict short- and long-term outcome and in the context of baseline clinical ..
  86. ncbi Elevated cardiac troponin T in peritoneal dialysis patients is associated with CRP and predicts all-cause mortality and cardiac death
    Christian Löwbeer
    Division of Clinical Chemistry, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden
    Nephrol Dial Transplant 17:2178-83. 2002
    Cardiac troponin T (cTnT) is a highly sensitive and specific marker of myocardial damage. In sera from patients with end-stage renal disease, cTnT may be elevated without other signs of acute myocardial injury...
  87. ncbi Differential use of cardiac troponin T versus I in hemodialysis patients
    T Fehr
    Division of Nephrology, University Hospital, Zurich, Switzerland
    Clin Nephrol 59:35-9. 2003
    Cardiac troponin T (cTnT) is frequently elevated in asymptomatic hemodialysis (HD) patients and predicts increased cardiovascular morbidity and mortality. Compared to cTnT, cardiac troponin I (cTnI) has a shorter half-life...
  88. ncbi Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension
    Adam Torbicki
    Department of Chest Medicine, Institute of Tuberculosis and Lung Diseases, Medical University of Warsaw, Poland
    Circulation 108:844-8. 2003
    ..We checked whether detection of cardiac troponin T (cTnT), a specific marker of myocyte injury, could be useful in prognostic stratification of those patients.
  89. ncbi Serum cardiac troponin T in patients hospitalized with heart failure is associated with left ventricular hypertrophy and systolic dysfunction
    C Löwbeer
    Division of Clinical Chemistry, Department of Laboratory Medicine, Medilab AB, Box 1550, SE 183 15 Täby, Sweden
    Scand J Clin Lab Invest 64:667-76. 2004
    Cardiac troponin T (cTnT) is a highly sensitive and specific marker of acute myocardial infarction...
  90. ncbi Elevated cardiac troponin T in hemodialysis patients receiving more intravenous iron sucrose
    Galip Guz
    Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey
    Ren Fail 26:663-72. 2004
    Elevated cardiac troponin T (cTnT) has been associated with shorter survival in hemodialysis patients...
  91. ncbi Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation
    Murali Chandra
    Dept of VCAPP, Washington State Univ, Pullman, WA 99164, USA
    Am J Physiol Heart Circ Physiol 289:H2112-9. 2005
    How different mutations in cardiac troponin T (cTnT) lead to distinct secondary downstream cellular remodeling in familial hypertrophic cardiomyopathy (FHC) remains elusive...
  92. doi Usefulness of peak troponin-T to predict infarct size and long-term outcome in patients with first acute myocardial infarction after primary percutaneous coronary intervention
    Ayman K M Hassan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 103:779-84. 2009
    In acute myocardial infarction cardiac troponin-T (cTnT) is the preferred biomarker to detect myocardial necrosis...
  93. pmc Cardiac troponin T elevation after stroke: relationships between elevated serum troponin T, stroke location, and prognosis
    Hwa Suk Song
    Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Clin Neurol 4:75-83. 2008
    Elevation of serum cardiac troponin T (cTnT) is regarded as a specific marker of acute coronary syndrome. Serum cTnT can be increased in patients with acute ischemic stroke, but its clinical implications remain unclear...
  94. doi Impact of cardiac troponin T N-terminal deletion and phosphorylation on myofilament function
    Marius P Sumandea
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    Biochemistry 48:7722-31. 2009
    Cardiac troponin T (cTnT) is a phosphoprotein that modulates cardiac muscle contraction through its extensive and diverse interactions with neighboring thin filament proteins...
  95. ncbi Cardiac troponin T for risk stratification in decompensated chronic heart failure
    Carlos Henrique del Carlo
    Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 92:372-80, 389-97, 404-12. 2009
    ..The cardiac troponins are highly sensitive and specific markers of myocardial injury. They have been detected in heart failure (HF) and are associated with a bad prognosis...
  96. doi Prospective, comprehensive assessment of cardiac troponin T testing after coronary artery bypass graft surgery
    Asim A Mohammed
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Circulation 120:843-50. 2009
    ..The significance and clinical role of cardiac troponin testing after coronary artery bypass grafting remain unclear...
  97. ncbi Cardiac troponin T as a prognostic marker in patients with heart failure : a 3-year outcome study
    Mesut Demir
    Department of Cardiology, Cukurova University, School of Medicine, Adana, Turkey
    Angiology 58:603-9. 2007
    Cardiac troponin T (cTnT), a highly sensitive and specific indicator of myocardial cell death, may be elevated in congestive heart failure (CHF)...
  98. ncbi cTnT can be a useful marker for early detection of anthracycline cardiotoxicity
    S Kilickap
    Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Ann Oncol 16:798-804. 2005
    The level of serum cardiac troponin-T (cTnT) increases with myocardial damage. We sought to assess whether cTnT level could be a useful marker for the early detection of anthracycline cardiotoxicity.
  99. ncbi Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes
    Jil C Tardiff
    Department of Physiology and Biophysics and the Department of Medicine Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Heart Fail Rev 10:237-48. 2005
    ..of the major structural components of the cardiac sarcomere: the thick filament (beta MyHC), the thin filament (cTnT and Tm) and associated proteins (MyBP-C)...
  100. doi Impact of time to reperfusion after acute myocardial infarction on myocardial damage assessed by left ventricular longitudinal strain
    Matteo Bertini
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 104:480-5. 2009
    The relation between cardiac troponin T (cTnT) and regional strain in patients with acute myocardial infarction (AMI) was investigated...
  101. doi FGF-23 and osteoprotegerin are independently associated with myocardial damage in chronic kidney disease stages 3 and 4. Another link between chronic kidney disease-mineral bone disorder and the heart
    Martin L Ford
    Brighton and Sussex Medical School, Brighton, UK
    Nephrol Dial Transplant 27:727-33. 2012
    ..Troponin T (cTnT) is released from cardiac myocytes under conditions of stress and is predictive of mortality across a range of ..

Research Grants43

  1. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The cardiac troponin complex (CTn) is made up of cardiac troponin T (CTnT), that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction ..
  2. Jian Ping Jin; Fiscal Year: 2014
    ..This research project investigates the role of a novel posttranslational modification of cardiac TnT (cTnT) in myocardial adaptation to energetic crisis...
  3. Jose Renato Pinto; Fiscal Year: 2014
    Project Summary The cardiac troponin complex (CTn) is made up of cardiac troponin T (CTnT), that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction and cardiac/slow ..
  4. Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament Activation
    Murali Chandra; Fiscal Year: 2012
    ..interactions among contractile regulatory pro- teins, which include cardiac troponin C (cTnC), troponin T (cTnT), troponin I (cTnI), and tropomyosin (Tm)...
  5. Structural Mechanisms Modulating Contraction in Normal and Diseased Heart
    Paul R Rosevear; Fiscal Year: 2010
    ..troponin (cTn) is the calcium sensitive switch consisting of troponin C (cTnC), troponin I (cTnl), and troponin T (cTnT). Unique isoforms of the cardiac subunits allow modification of heart contraction during development and disease...
  6. FHC Tn Mutations: Functional Consequences & Mechanisms
    James Potter; Fiscal Year: 2005
    ..heavy chain (MHC) mutations, in general, have a higher level of cardiac hypertrophy, those with cardiac Troponin T (CTnT) and some of the reported Troponin I (CTnI) mutations have less hypertrophy and a higher incidence of sudden ..
  7. CARDIAC MUSCLE--MOLECULAR MECHANISMS OF REGULATION
    JOHN PUTKEY; Fiscal Year: 2000
    ..Unfortunately, cTnC and the interactions between cTnC and cTnT have unique and clinically important features which can not be studied using the skeletal isoforms...
  8. REGULATION OF CARDIAC CROSS-BRIDGES BY TROPONIN T
    SCOTT BUCK; Fiscal Year: 2004
    ..abstract_text> ..
  9. High sensitivity Troponin T as a novel predictor of cardiovascular events
    ALEXIS LYNN BEATTY; Fiscal Year: 2012
    ..This study proposes to evaluate the relationship between high-sensitivity cardiac Troponin T (hs-cTnT) and cardiovascular outcomes in subjects from the Heart and Soul Study, a longitudinal cohort study of 1024 ..
  10. ALDRIN VERNO GOMES; Fiscal Year: 2014
    ..Mutations in cardiac troponin T (cTnT) are responsible for ~7% of all familial hypertrophic cardiomyopathy (FHC) cases...
  11. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..We previously show that the transgene expression driven by rat cardiac troponin T (cTnT) proximal promoter is faithfully recapitulated the endogenous cTnT expression throughout the embryonic development ..
  12. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2006
    ..HIV seroreverter cohorts to determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are affected ..
  13. MECHANISM OF MIS-SPLICING IN MYOTONIC DYSTROPHY 1
    MUGE KUYUMCU MARTINEZ; Fiscal Year: 2007
    ..CUG-BP1 regulates alternative splicing of cardiac troponin T (cTNT), insulin receptor (IR) and chloride channel (CIC-1) pre-mRNAs that are mis-spliced in DM1 striated muscle...
  14. MOLECULAR STUDY OF CARDIOGENESIS
    Charles Ordahl; Fiscal Year: 2002
    ..between two distinct regulatory domains that control cardiac-specific transcription of the cardiac troponin T gene (cTNT)...
  15. CARDIAC TROPONIN T MUTATIONS AND HEART FUNCTION
    Amy Sehnert; Fiscal Year: 2003
    ..The proposed research plan specifically addresses the affect of cardiac troponin T (cTnT) mutations on cardiac contractility...
  16. TRANSCRIPTION OF MUSCLE-SPECIFIC GENES IN MYOGENESIS
    Charles Ordahl; Fiscal Year: 1992
    ..We have characterized an embryo specific muscle gene, the gene encoding cardiac troponin T (cTNT)...
  17. Troponin Elevation in Patients with Acute Coronary Syndrome & Decreased Kidney Fu
    Claudine T Jurkovitz; Fiscal Year: 2010
    ..This study will be a retrospective analysis of patients with documented cTnT admitted to the Christiana Care Health System since 2004...
  18. MUTANT SARCOMERIC PROTEINS AND CARDIAC DISEASE
    Joseph Metzger; Fiscal Year: 2007
    ..Aim 2. To determine whether specific DCM and HCM mutations in tropomyosin (Tm) and cardiac troponin T (cTnT) will produce specific and distinct differences in cardiac myocyte performance...
  19. Jil C Tardiff; Fiscal Year: 2016
    ..We now turn our attention to both TM and cTnT and focus on two unique disease mechanisms that are likely to be involved in the earliest development of ..
  20. TROPONIN MODULATION IN HEART FAILURE
    Beata M Wolska; Fiscal Year: 2013
    ..the functional significance of diverse pathways of activation of PKC6 that induce dephosphorylation of cTnI and cTnT and phosphorylation of MyBP- C and Tm...
  21. Jil C Tardiff; Fiscal Year: 2016
    ..The fact that the mutations we plan to study (all in cTnT) have in some cases been shown to effect significant changes on both these control mechanisms seems to demonstrate ..
  22. DEVELOPMENTAL CORRELATES-- MEMBRANE/CONTRACTILE PROTEIN
    Page Anderson; Fiscal Year: 2004
    ..Myofilament function is regulated by troponin, a complex made of three subunits (cTnI, cTnC, cTnT): cTnI inhibits actin-myosin interaction, the binding of Ca2+ to cTnC disinhibits this interaction, and cTnT binds ..
  23. Artificial site-specific RNA endonuclease as new Myotonic Dystrophy therapeutics
    Zefeng Wang; Fiscal Year: 2012
    ..ARSE treatment can reverse the mis-splicing of genes affected in patients and transgenic DM1 mouse (such as CIC-1, cTnT and SERCA1)...
  24. Wen Yi Chen; Fiscal Year: 2014
    ..Of these, more than 80% can be found in 7 genes, namely LMNA, MYH6, MYH7, MYPN, TNNT2, SCN5a, and MYBPC3...
  25. SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Douglas Mann; Fiscal Year: 2004
    ..Renin-angiotensin system (RAS) inhibitors will be assessed in transgenics harboring the human cTNT mutation and, in preparation for future gene therapy, Gene-Switch will be used to determine if the phenotype is ..
  26. Signaling Pathways in Cardiac Hypertrophy
    STEPHEN LUCKEY; Fiscal Year: 2005
    ..alpha-myosin heavy chain (alpha-MHC), and both a missense mutation and a truncated molecule of cardiac troponin T (cTnT)...
  27. Signaling in pathological & physiological hypertrophy
    JOHN KONHILAS; Fiscal Year: 2004
    ..Additional models contain a missense mutation of cardiac troponin T (cTnT) or a truncated cTnT. Interestingly, cTnT mutations result in significantly decreased ventricular mass...
  28. Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer Survivors
    Steven Lipshultz; Fiscal Year: 2009
    ..of cardiac function via echocardiography and analysis of serum biomarkers of cardiac risk (lipids, proBNP, hsCRP, cTnT). We will determine: 1...
  29. CALCIUM SIGNALING IN CARDIAC MYOFILAMENTS
    R Solaro; Fiscal Year: 1999
    ..Experiments proposed here test the hypothesis that isoform switching and phosphorylation of cardiac TnI (cTnI) and cTnT are important elements in the intrinsic (Starling's Law) and extrinsic (neurohumoral) control of cardiac output...
  30. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    We hypothesize that the analytical and clinical validation of cardiac troponin (cTnl) and cardiac troponin T (cTnT) will enable the establishment of reference ranges in a healthy population to be used as cutoff levels for the sensitive ..
  31. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  32. MECHANISMS OF HORMONE THERAPY IN POSTMENOPAUSAL WOMEN
    L Newby; Fiscal Year: 2003
    ....
  33. REG OF SM22 ALPHA TRANSCRIPTION IN SMOOTH MUSCLE CELLS
    Michael Parmacek; Fiscal Year: 2005
    ....
  34. Developmental regulation of cardiac gene expression
    Anthony Azakie; Fiscal Year: 2007
    ..An understanding of the transcriptional mechanisms that control cardiogenesis may also elucidate the molecular pathogenesis of various congenital heart defects and cardiomyopathies. ..
  35. Molecular Basis of Myocardin Function in the Heart
    Michael S Parmacek; Fiscal Year: 2010
    ..These studies will provide new understanding into cardiac development as well as the underlying causes of heart failure and cardiomyopathy. ..
  36. Cellular Mechanisms in the Pathogenesis of FHC
    JIL TARDIFF; Fiscal Year: 2006
    ..To date, all of the mutations linked to FHC encode sarcomeric proteins. Mutations in the cardiac Troponin T (cTnT) gene result in a particularly poor clinical outcome...
  37. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2009
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  38. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2008
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  39. Testosterone in TNFR1 Signaling During Acute Myocardial Injury
    Meijing Wang; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  40. CORONARY THROMBOSIS AND RISK IN THE EMERGENCY DEPARTMENT
    Gary Green; Fiscal Year: 2003
    ..The ED physician's judgement will then be compared to the potential clinical utility and cost effectiveness of this "comprehensive predictive instrument" for both diagnosis and risk stratification. ..
  41. REGULATION OF CARDIAC MYOGENESIS
    PARKER ANTIN; Fiscal Year: 2002
    ..This information will increase our understanding of both normal and abnormal heart development and may suggest ways to alter heart development or replication of cardiac myocytes. ..
  42. Gordon Research Conference:Cardiac Regulatory Mechanisms
    R Solaro; Fiscal Year: 2002
    ..Much of the time of the meeting is devoted to debates and discussion. Presentations of late breaking science from young investigator will be added from the posters submitted to the meeting. ..