TNIK

Summary

Gene Symbol: TNIK
Description: TRAF2 and NCK interacting kinase
Alias: MRT54, TRAF2 and NCK-interacting protein kinase
Species: human

Top Publications

  1. pmc Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes
    H Yonekura
    Department of Biochemistry, Center for Biomedical Research, Kanazawa University School of Medicine, Kanazawa 920 8640, Japan
    Nucleic Acids Res 27:2591-600. 1999
  2. ncbi Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta
    Yuanming Hu
    Rigel Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    J Biol Chem 279:54387-97. 2004
  3. ncbi TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
    C A Fu
    Rigel, Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:30729-37. 1999
  4. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
  5. pmc The kinase TNIK is an essential activator of Wnt target genes
    Tokameh Mahmoudi
    Hubrecht Institute KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 28:3329-40. 2009
  6. ncbi The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
    Kiyohito Taira
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:49488-96. 2004
  7. pmc Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer
    Hidenori Takahashi
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    BMC Cancer 15:794. 2015
  8. doi The essential role of TNIK gene amplification in gastric cancer growth
    D H Yu
    Innovation Center China, AstraZeneca, Shanghai, China
    Oncogenesis 2:e89. 2014
  9. pmc The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation
    Sarah V Consonni
    Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e98253. 2014
  10. doi Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis
    Jing Jin
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Pathol Res Pract 210:621-7. 2014

Research Grants

  1. THOMAS J O'DELL; Fiscal Year: 2016
  2. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006

Scientific Experts

  • S G Potkin
  • Nicholas J Bradshaw
  • S E Holmes
  • Hiroshi Kawabe
  • THOMAS J O'DELL
  • Mari Masuda
  • Tesshi Yamada
  • Jinghua Gui
  • Qi Wang
  • Jiyeon Kim
  • Ken Ichi Kariya
  • Hong Ji
  • Bow J Tauro
  • Marcelo P Coba
  • Miki Shitashige
  • Reiko Satow
  • Yukiko Uechi
  • Q Xu
  • Zhi Tan
  • Hae Jung Chon
  • Shams Anazi
  • Yong Zhang
  • Masaaki Sawa
  • Masato Umikawa
  • Nicholas J Brandon
  • Kimiko Takei
  • Michael D Ehlers
  • Tzer Bin Lin
  • Hidenori Takahashi
  • Alain C Burette
  • Claudia Colombrita
  • Sarah V Consonni
  • D H Yu
  • Jing Jin
  • Meihong Wong
  • Lan Xu
  • Xin Huang
  • Dong Seok Park
  • Johannes L Bos
  • Koc Kan Ho
  • David W Greening
  • Suresh Mathivanan
  • Richard J Simpson
  • Xiumei Zhou
  • Alexander Mikryukov
  • Christian Schürch
  • Martijn Gloerich
  • M Ayalew
  • Anna Shkoda
  • Seth G N Grant
  • Satoshi Kaneko
  • Erik J MacLaren
  • Q Wang
  • Hans Clevers
  • Kazufumi Honda
  • Masaya Ono
  • Takafumi Jigami
  • Setsuo Hirohashi
  • Natasha K Hussain
  • Tokameh Mahmoudi
  • Maitsetseg Bayarjargal
  • Minoru Oshiro
  • Tsuyoshi Asato
  • Shogo Endo
  • Yoshito Yamashiro
  • Hideo Nonaka
  • H Wang
  • Yuanming Hu
  • Kiyohito Taira
  • Stephen P Amato
  • Naoko Goto
  • Hirokazu Ohata
  • Mohamed Abouelhoda
  • Khalid Al-Rubeaan
  • Dorota Monies
  • Yuko Uno
  • Lu Chen
  • Xiangyu Su
  • Naomi Ohbayashi
  • Mustafa A Salih
  • M Li
  • Z Yi
  • L He
  • Hanan E Shamseldin
  • David M Rubitski
  • Ayako Mimata
  • X Wu
  • Kyoung Jun Bae
  • Fowzan S Alkuraya
  • Koji Okamoto

Detail Information

Publications49

  1. pmc Antisense display--a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes
    H Yonekura
    Department of Biochemistry, Center for Biomedical Research, Kanazawa University School of Medicine, Kanazawa 920 8640, Japan
    Nucleic Acids Res 27:2591-600. 1999
    ..The results suggest that the antisense display method is potentially useful for isolating new genes towards elucidating their functions...
  2. ncbi Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta
    Yuanming Hu
    Rigel Pharmaceuticals, Inc, South San Francisco, California 94080, USA
    J Biol Chem 279:54387-97. 2004
    ..Similar to Nck interacting kinase (NIK) and Traf2 and Nck-interacting kinase (TNIK), hMINK beta moderately activates c-Jun N-terminal kinase (JNK) and associates with Nck via the intermediate domain ..
  3. ncbi TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
    C A Fu
    Rigel, Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:30729-37. 1999
    ..Here we describe the cloning and characterization of a novel GCK family kinase, Traf2- and Nck-interacting kinase (TNIK) that interacts with both Traf2 and Nck. TNIK encodes a polypeptide of 1360 amino acids with eight spliced isoforms...
  4. pmc Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
    Hiroshi Kawabe
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Neuron 65:358-72. 2010
    ..Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A...
  5. pmc The kinase TNIK is an essential activator of Wnt target genes
    Tokameh Mahmoudi
    Hubrecht Institute KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 28:3329-40. 2009
    ..Using a proteomics approach, we identified Tnik, a member of the germinal centre kinase family as a Tcf4 interactor in the proliferative crypts of mouse small ..
  6. ncbi The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton
    Kiyohito Taira
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Biol Chem 279:49488-96. 2004
    ..By liquid chromatography tandem mass spectrometry, we have identified p155 as Traf2- and Nck-interacting kinase (TNIK)...
  7. pmc Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer
    Hidenori Takahashi
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    BMC Cancer 15:794. 2015
    ..The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC)...
  8. doi The essential role of TNIK gene amplification in gastric cancer growth
    D H Yu
    Innovation Center China, AstraZeneca, Shanghai, China
    Oncogenesis 2:e89. 2014
    Traf2- and Nck-interacting kinase (TNIK) is one of the germinal center kinase family members involved in cytoskeleton organization and neuronal dendrite extension...
  9. pmc The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation
    Sarah V Consonni
    Department of Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e98253. 2014
    ..activates Rap2a resulting in induction of brush border formation via a pathway that includes the polarity players TNIK, Mst4 and Ezrin...
  10. doi Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis
    Jing Jin
    Department of Pathology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Pathol Res Pract 210:621-7. 2014
    TRAF2- and NCK-interacting kinase (TNIK) is a member of the germinal center kinase family and a transcription factor 4 (TCF4) interactor is recruited to promoters of Wnt target genes via phosphorylation of the TCF/β-catenin complex...
  11. pmc Silencing of STRN4 suppresses the malignant characteristics of cancer cells
    Meihong Wong
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 105:1526-32. 2014
    ..We previously reported that STRN4 directly associated with protein kinases, such as MINK1, TNIK and MAP4K4, which are associated with tumor suppression or tumor progression...
  12. pmc A novel aminothiazole KY-05009 with potential to inhibit Traf2- and Nck-interacting kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells
    Jiyeon Kim
    Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Jung Gu, Daejeon, Republic of Korea
    PLoS ONE 9:e110180. 2014
    ..Traf2- and Nck-interacting kinase (TNIK) has recently been considered as a first-in-class anti-cancer target molecule to regulate Wnt signaling pathway, ..
  13. pmc Organization of TNIK in dendritic spines
    Alain C Burette
    Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, 27599
    J Comp Neurol 523:1913-24. 2015
    ..factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1)...
  14. doi TNIK serves as a novel biomarker associated with poor prognosis in patients with pancreatic cancer
    Yong Zhang
    Department of Gastrointestinal Surgery, Inner Mongolia People s Hospital, No 20 Zhao Wuda Road, Inner Mongolia, Hohhot, 010017, China
    Tumour Biol 37:1035-40. 2016
    Traf-2 and Nck interacting kinase (TNIK) is one of the STE20/MAP4K family members implicated in carcinogenesis and progression of several human malignancies...
  15. doi Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population
    Q Xu
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    Pharmacogenomics J 16:357-65. 2016
    ..Also, we found several new candidate genes (TNIK, RELN, NOTCH4 and SLC6A2) and combinations (haplotype rs1544325-rs5993883-rs6269-rs4818 in COMT) that are ..
  16. doi From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models
    Claudia Colombrita
    Department of Pathophysiology and Transplantation, Dino Ferrari Center Università degli Studi di Milano, Milan 20122, Italy Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy
    Biochim Biophys Acta 1849:1398-410. 2015
    ..TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA metabolism (DICER, ELAVL3/HuC, POLDIP3)...
  17. pmc Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor
    Zhi Tan
    Integrated Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Sci Rep 6:33534. 2016
    TRAF2- and NCK-interacting kinase (TNIK) represents one of the crucial targets for Wnt-activated colorectal cancer...
  18. pmc TNIK inhibition abrogates colorectal cancer stemness
    Mari Masuda
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Nat Commun 7:12586. 2016
    ..We and others have previously identified Traf2- and Nck-interacting kinase (TNIK) as an essential regulatory component of the T-cell factor-4 and β-catenin transcriptional complex...
  19. doi Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
    Mari Masuda
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Pharmacol Ther 156:1-9. 2015
    ..Traf2- and Nck-interacting protein kinase (TNIK) has been identified as a regulatory component of the T-cell factor-4 and β-catenin transcriptional complex ..
  20. doi Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK
    Qi Wang
    Neuroscience and Pain Research Unit, BioTherapeutics Research and Development, Pfizer Inc Cambridge, Massachusetts Q W, S p A, D M R, N J B, M D E Center of Chemistry Innovation and Excellence, Pfizer Inc, Groton, Connecticut M M H Neuroscience Medicinal Chemistry, Pfizer Inc, Cambridge, Massachusetts B L K, P R V and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts L X
    J Pharmacol Exp Ther 356:410-23. 2016
    Traf2- and Nck-interacting kinase (TNIK) is a serine/threonine kinase highly expressed in the brain and enriched in the postsynaptic density of glutamatergic synapses in the mammalian brain...
  21. doi Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade
    Tzer Bin Lin
    Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11049, Taiwan, Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan, Department of Biotechnology, Asia University, Taichung 41354, Taiwan
    J Neurosci 35:16545-60. 2015
    ..we report that the abundance of tumor necrosis factor receptor-associated factor 2 and NcK-interacting kinase (TNIK), a kinase that is presumed to regulate neural plasticity, was specifically enhanced in ipsilateral dorsal horn ..
  22. doi Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells
    Hae Jung Chon
    Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, 34824, Korea
    Amino Acids 48:1591-9. 2016
    Traf2- and Nck-interacting kinase (TNIK) is a member of the germinal center kinase family...
  23. doi A null mutation in TNIK defines a novel locus for intellectual disability
    Shams Anazi
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Hum Genet 135:773-8. 2016
    ..Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein...
  24. pmc Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    M Ayalew
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Psychiatry 17:887-905. 2012
    ..NDUFV2, RAB18, as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RELN, SNAP-25, TNIK), brain development, myelination, cell adhesion, glutamate receptor signaling, G-protein-coupled receptor signaling ..
  25. pmc DISC1-binding proteins in neural development, signalling and schizophrenia
    Nicholas J Bradshaw
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, Midlothian EH4 2XU, UK
    Neuropharmacology 62:1230-41. 2012
    ..neural progenitor proliferation (GSK3β), neurosignalling (Girdin, GSK3β, PDE4) and synaptic function (Kal7, TNIK)...
  26. doi Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    Bow J Tauro
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia
    Methods 56:293-304. 2012
    ..Additionally, several cancer-related proteins were identified in IAC-Exos including various ephrins (EFNB1, EFNB2) and Eph receptors (EPHA2-8, EPHB1-4), and components involved in Wnt (CTNNB1, TNIK) and Ras (CRK, GRB2) signalling.
  27. pmc CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression
    Christian Schürch
    Tumor Immunology, Department of Clinical Research, University of Bern, Bern, Switzerland
    J Clin Invest 122:624-38. 2012
    ..target genes in LSCs by enhancing nuclear localization of active β-catenin and TRAF2- and NCK-interacting kinase (TNIK). This resulted in increased proliferation and differentiation of LSCs...
  28. doi Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling
    Dong Seok Park
    Department of Biomedical Sciences, University of Ulsan College of Medicine, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Biochem Biophys Res Commun 436:338-43. 2013
    ..Furthermore, we found that TRAF2/Nck-interacting kinase (TNIK), a member of the Ste20 protein family, acts as a downstream effector of Rap2 in control of LRP6 stabilization...
  29. doi Differences in the transcriptional profiles of human cumulus cells isolated from MI and MII oocytes of patients with polycystic ovary syndrome
    Xin Huang
    Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao Medical University, 20 Yuhuangding Road East, Yantai, Shandong, 264000, People s Republic of China
    Reproduction 145:597-608. 2013
    ..levels in the microarrays and their putative functions, six differentially expressed genes (LHCGR, ANGPTL1, TNIK, GRIN2A, SFRP4, and SOCS3) were selected and analyzed by quantitative RT-PCR (qRT-PCR)...
  30. doi Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components
    Hong Ji
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia
    Proteomics 13:1672-86. 2013
    ..enrichment of metastatic factors (MET, S100A8, S100A9, TNC), signal transduction molecules (EFNB2, JAG1, SRC, TNIK), and lipid raft and lipid raft-associated components (CAV1, FLOT1, FLOT2, PROM1) in exosomes derived from ..
  31. doi Dynamic change of TNIK in response to tumor necrosis factor alpha in a TRAF2-dependent manner
    Jinghua Gui
    Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci Tech University, Mailbox 539, Hangzhou 310018, Zhejiang, People s Republic of China
    Hum Cell 26:67-72. 2013
    b>TNIK (TRAF2- and NCK-interacting kinase) was named because of its association with TRAF2 (tumor necrosis factor receptor-associated factor 2)...
  32. doi Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors
    Koc Kan Ho
    Astex Pharmaceuticals, Inc, 2401 South Foothill Drive, Salt Lake City, UT 84109, USA
    Bioorg Med Chem Lett 23:569-73. 2013
    ..scaffold that are potent and selective inhibitors of Traf2- and Nck-interacting kinase (TNIK) activity are described...
  33. pmc TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function
    Marcelo P Coba
    Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    J Neurosci 32:13987-99. 2012
    Traf2 and NcK interacting kinase (TNiK) contains serine-threonine kinase and scaffold domains and has been implicated in cell proliferation and glutamate receptor regulation in vitro...
  34. pmc Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling
    Alexander Mikryukov
    Laboratory of Growth and Development, Cancer Research Centre, Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e43330. 2012
    ..Here we show that TNIK (Traf2 and Nck-interacting kinase) and MINK (Misshapen/NIKs-related kinase) MAP4K signalling kinases are integral ..
  35. pmc The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
    Anna Shkoda
    Research Unit Gene Vectors, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Munchen, Germany
    PLoS Biol 10:e1001376. 2012
    The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center kinase family...
  36. doi Rap2A links intestinal cell polarity to brush border formation
    Martijn Gloerich
    Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht 3584 CG, The Netherlands
    Nat Cell Biol 14:793-801. 2012
    ..for successive signalling by the guanine nucleotide exchange factor PDZGEF, the small G protein Rap2A, its effector TNIK, the kinase MST4 and, ultimately, the actin-binding protein Ezrin...
  37. ncbi The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
    W Yan
    Department of Stomatology, University of California, San Francisco 94143, USA
    J Biol Chem 276:31349-56. 2001
    ..These findings indicate that NIK acts downstream of platelet-derived growth factor receptors to phosphorylate and activate NHE1 divergently of its activation of JNK...
  38. ncbi A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array
    S E Holmes
    Laboratory of Genetic Neurobiology, Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, CMSC 8 121, Baltimore, MD 21287, USA
    Hum Genet 120:193-200. 2006
    ..The closest experimentally verified gene in the region (TNIK, encoding a serine/threonine kinase) occurs approximately 63 Kb downstream from the repeat...
  39. doi MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1
    Hideo Nonaka
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 377:573-8. 2008
    ..MINK was enriched in the brain, and both MINK and its close relative, Traf2- and Nck-interacting kinase (TNIK), interacted with a postsynaptic scaffold protein containing tetratricopeptide repeats, ankyrin repeats and a ..
  40. pmc A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Bull 35:96-108. 2009
    ..We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia...
  41. doi Rap2 function requires palmitoylation and recycling endosome localization
    Yukiko Uechi
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Biochem Biophys Res Commun 378:732-7. 2009
    ..We have recently identified the Traf2- and Nck-interacting kinase (TNIK), a member of the STE20 group of mitogen-activated protein kinase kinase kinase kinases, as a specific Rap2 ..
  42. doi Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth
    Miki Shitashige
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5024-33. 2010
    ..We previously identified Traf2- and Nck-interacting kinase (TNIK) as one of the proteins that interact with TCF4 in colorectal cancer cells, but its functional significance has not ..
  43. pmc Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 285:26289-94. 2010
    ..We have recently identified Traf2- and Nck-interacting kinase (TNIK) as a novel activator of Wnt signaling through a comprehensive proteomic approach in human colorectal cancer cell ..
  44. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..Several of these genes (RSRC1, ARHGAP18, ROBO1-ROBO2, GPC1, TNIK, and CTXN3-SLC12A2) have functions related to progenitor cell proliferation, migration, and differentiation, ..
  45. pmc The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function
    Q Wang
    Pfizer Neuroscience Research Unit, Princeton, NJ, USA
    Mol Psychiatry 16:1006-23. 2011
    ..We identify the Traf2 and Nck-interacting kinase (TNIK), an emerging risk factor itself for disease, as a key synaptic partner for DISC1, and provide evidence that the ..
  46. pmc MINK and TNIK differentially act on Rap2-mediated signal transduction to regulate neuronal structure and AMPA receptor function
    Natasha K Hussain
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:14786-94. 2010
    Misshapen/NIKs (Nck-interacting kinases)-related kinase (MINK) and closely related TRAF2/Nck-interacting kinase (TNIK) are proteins that specifically bind to activated Rap2 and are thus hypothesized to relay its downstream signal ..
  47. pmc Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
    Erik J MacLaren
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Mol Cell Neurosci 47:93-9. 2011
    ..Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene...
  48. pmc Smad inhibition by the Ste20 kinase Misshapen
    Satoshi Kaneko
    Program in Molecular Medicine and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 108:11127-32. 2011
    ..Through RNAi screening of the kinome, we have identified Misshapen (Msn) and the mammalian orthologs TNIK, MINK1, and MAP4K4 as the kinases responsible for α-helix 1 phosphorylation...
  49. doi Enormous influence of TNIK knockdown on intracellular signals and cell survival
    Jinghua Gui
    Xinyuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci Tech University, Room 201, Building No 6, Xiasha, Hangzhou 310018, China
    Hum Cell 24:121-6. 2011
    ..As one of the central transcriptional factors, Traf2- and Nck-interacting kinase (TNIK) mediates the transactivation of Wnt target genes and promotes the activity of c-Jun N-terminus kinase (JNK)2 when ..

Research Grants2

  1. THOMAS J O'DELL; Fiscal Year: 2016
    ..mice with null mutations in the GluN1 subunit adaptor protein AKAP9 as well as the AKAP9-associated protein kinase TNiK. Importantly, several of the proteins to be examined in this proposal have been implicated in diseases such as ..
  2. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..