TNFSF13B

Summary

Gene Symbol: TNFSF13B
Description: TNF superfamily member 13b
Alias: BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4, tumor necrosis factor ligand superfamily member 13B, ApoL related ligand TALL-1, B-cell-activating factor, B-lymphocyte stimulator, Delta4 BAFF, TNF and ApoL-related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, delta BAFF, dendritic cell-derived TNF-like molecule, tumor necrosis factor (ligand) superfamily, member 13b, tumor necrosis factor (ligand) superfamily, member 20, tumor necrosis factor ligand 7A, tumor necrosis factor superfamily member 13b, tumor necrosis factor-like protein ZTNF4
Species: human

Top Publications

  1. ncbi BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
    J S Thompson
    Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA, The Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
    Science 293:2108-11. 2001
  2. doi Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    Michelle Petri
    Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD 21205, USA
    Arthritis Rheum 58:2453-9. 2008
  3. ncbi Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome
    Anne J Novak
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Blood 104:2247-53. 2004
  4. doi Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors
    Matthias Kreuzaler
    Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    J Immunol 188:497-503. 2012
  5. doi B cell-activating factor: its clinical significance in multiple myeloma patients
    M Fragioudaki
    Hematology Department, University Hospital of Heraklion, PO Box 1352, Heraklion, Crete, Greece
    Ann Hematol 91:1413-8. 2012
  6. doi Evaluation of TNF superfamily molecules in multiple myeloma patients: correlation with biological and clinical features
    Dorota Lemancewicz
    Department of Human Anatomy, Medical University of Bialystok, Poland
    Leuk Res 37:1089-93. 2013
  7. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
  8. ncbi BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligands
    Ghada Alsaleh
    EA 3432, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Arthritis Rheum 56:3202-14. 2007
  9. doi Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF
    Ghada Alsaleh
    Laboratoire Physiopathologie des Arthrites, Universite de Strasbourg, UFR Sciences Pharmaceutiques, Illkirch, France
    Eur J Immunol 41:2113-22. 2011
  10. pmc Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis
    Kai Liu
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 7:e38429. 2012

Research Grants

  1. Jeffrey C Rathmell; Fiscal Year: 2014
  2. John C Cambier; Fiscal Year: 2014
  3. Judith A James; Fiscal Year: 2016
  4. David V Serreze; Fiscal Year: 2016
  5. Robert P Schleimer; Fiscal Year: 2016
  6. TIMOTHY L MANSER; Fiscal Year: 2014
  7. B-Cell Tolerance Mechanisms in Human SLE
    JENNIFER HOWITT ANOLIK; Fiscal Year: 2013
  8. CHRISTINE MOREL COQUERY; Fiscal Year: 2014
  9. Impact of regulatory T cells on human peripheral B cell tolerance
    Eric Meffre; Fiscal Year: 2013
  10. Loren D Erickson; Fiscal Year: 2016

Detail Information

Publications213 found, 100 shown here

  1. ncbi BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
    J S Thompson
    Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA, The Institute of Biochemistry, University of Lausanne, CH 1066, Epalinges, Switzerland
    Science 293:2108-11. 2001
    B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family...
  2. doi Association of plasma B lymphocyte stimulator levels and disease activity in systemic lupus erythematosus
    Michelle Petri
    Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD 21205, USA
    Arthritis Rheum 58:2453-9. 2008
    To determine the association of plasma B lymphocyte stimulator (BLyS) levels, immunosuppressive therapy, and other clinical parameters with disease activity in systemic lupus erythematosus (SLE).
  3. ncbi Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome
    Anne J Novak
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Blood 104:2247-53. 2004
    ..found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors (BCMA, TACI, and BAFF-R) for BLyS; however, the pattern of expression was variable...
  4. doi Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors
    Matthias Kreuzaler
    Department of Biomedicine, University of Basel, 4058 Basel, Switzerland
    J Immunol 188:497-503. 2012
    The TNF family member protein BAFF/BLyS is essential for B cell survival and plays an important role in regulating class switch recombination as well as in the selection of autoreactive B cells...
  5. doi B cell-activating factor: its clinical significance in multiple myeloma patients
    M Fragioudaki
    Hematology Department, University Hospital of Heraklion, PO Box 1352, Heraklion, Crete, Greece
    Ann Hematol 91:1413-8. 2012
    B cell-activating factor (BAFF) is a cytokine that plays a major role in the maintenance of normal B-cell development and homeostasis...
  6. doi Evaluation of TNF superfamily molecules in multiple myeloma patients: correlation with biological and clinical features
    Dorota Lemancewicz
    Department of Human Anatomy, Medical University of Bialystok, Poland
    Leuk Res 37:1089-93. 2013
    B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL) and apoptosis inducing ligand (TRAIL) are members of the tumour necrosis factor (TNF) family...
  7. pmc BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
    P Schneider
    Institute of Biochemistry, University of Lausanne, Switzerland
    J Exp Med 189:1747-56. 1999
    ..Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells...
  8. ncbi BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively regulated by tumor necrosis factor alpha and Toll-like receptor ligands
    Ghada Alsaleh
    EA 3432, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Arthritis Rheum 56:3202-14. 2007
    It was recently demonstrated that synoviocytes (FLS) from rheumatoid arthritis (RA) patients express BAFF transcripts that are up-regulated by tumor necrosis factor alpha (TNFalpha) and interferon-gamma (IFNgamma)...
  9. doi Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF
    Ghada Alsaleh
    Laboratoire Physiopathologie des Arthrites, Universite de Strasbourg, UFR Sciences Pharmaceutiques, Illkirch, France
    Eur J Immunol 41:2113-22. 2011
    ..RA FLSs can directly promote CSR and to analyze the role of external factors like TLR signals and BAFF (B cell activating factor) family cytokines in this FLS-B cell crosstalk, we performed cocultures of blood B cells (from normal ..
  10. pmc Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis
    Kai Liu
    MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    PLoS ONE 7:e38429. 2012
    ..Therefore, identification of more validated biomarkers and phenotypic signatures is imperative. In particular, T cell-related biomarkers are more significant...
  11. ncbi Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase
    A Mukhopadhyay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:15978-81. 1999
    ..sequence tag data base and identified a novel full-length cDNA encoding 285 amino acid residues and named it THANK. THANK is a type II transmembrane protein with 15-20% overall amino acid sequence homology to TNF, LT-alpha, FasL, ..
  12. doi B-Lymphocyte stimulator: a new biomarker for multiple myeloma
    Pu Jiang
    Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China
    Eur J Haematol 82:267-76. 2009
    ..Considering the biological function of B-Lymphocyte stimulator (BLyS) and its receptors in B cell, we examined BLyS and its receptors expression in MM cells...
  13. doi Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid
    Samia Ragheb
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Mult Scler 17:819-29. 2011
    ..B-cell activating factor (BAFF) has an essential role in B-cell homeostasis...
  14. pmc The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients
    Yunying Chen
    Clinical Allergy Research Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden
    PLoS ONE 6:e22202. 2011
    The TNF family cytokines BAFF (B-cell activating factor of the TNF family) and APRIL (a proliferation-inducing ligand) are crucial survival factors for B-cell development and activation...
  15. doi BAFF and BAFF-R levels are associated with risk of long-term kidney graft dysfunction and development of donor-specific antibodies
    A Thibault-Espitia
    Institut National de la Santé Et de la Recherche Médicale INSERM U643, and Institut de Transplantation Urologie, Nephrologie, Nantes, France
    Am J Transplant 12:2754-62. 2012
    There are lines of evidence that B cells may play a role in transplantation. B cell activating factor, BAFF, is a homotrimer that has been shown to play a role in B cell survival, maturation and activation...
  16. doi Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome
    V Fühlhuber
    Dept of Neurology, Justus Liebig University, Giessen, Germany
    J Neuroimmunol 210:87-91. 2009
    ..While the newly discovered B-cell activating factors BAFF and APRIL are involved in systemic autoimmune diseases, their association with neuroimmunological diseases is ..
  17. ncbi TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
    J A Gross
    Department of Immunology, ZymoGenetics, Seattle, Washington 98102, USA
    Nature 404:995-9. 2000
    ..b>zTNF4 (BLyS, BAFF, TALL-1, THANK) is a member of the tumour necrosis factor (TNF) ligand family that is a potent co-..
  18. ncbi APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity
    G Yu
    Department of Inflammation, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Nat Immunol 1:252-6. 2000
    ..maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding...
  19. pmc DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand...
  20. ncbi Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands
    Yingfang Liu
    National Jewish Medical and Research Center, Integrated Department of Immunology, Denver, CO 80206, USA
    Cell 108:383-94. 2002
    TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis factor (TNF) ligand family. The crystal structure of the functional soluble TALL-1 (sTALL-1) has been determined at 3.0 A...
  21. ncbi Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production
    Susan L Kalled
    Biogen Idec, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Semin Immunol 18:290-6. 2006
    ..Identification of the B cell survival factor, BAFF, was a key discovery in understanding the survival mechanism for mature B cells in the periphery...
  22. ncbi TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    H B Shu
    National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Department of Immunology, Denver 80206, USA
    J Leukoc Biol 65:680-3. 1999
    ..Furthermore, TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin...
  23. doi Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways
    Marc Ittah
    Rhumatologie, Institut Pour la Santé et la Recherche Médicale INSERM U 802, Hopital Bicetre, Assistance Publique Hopitaux de Paris, Universite Paris Sud 11, Le Kremlin Bicetre, France
    Eur J Immunol 38:1058-64. 2008
    b>B cell activating factor (BAFF) plays a key role in promoting B lymphocyte activation...
  24. ncbi Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
    Catherine Kern
    U365 INSERM, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Blood 103:679-88. 2004
    Tumor necrosis factor (TNF) superfamily members BAFF, or B-cell activation factor of the TNF family, and APRIL, a proliferation-inducing ligand, are involved in normal B-cell survival and differentiation...
  25. ncbi Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment
    Yu Tzu Tai
    The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 66:6675-82. 2006
    Recent studies have underscored the role of B-cell-activating factor (BAFF), a member of the tumor necrosis factor superfamily, in promoting the survival of malignant B cells, including human multiple myeloma...
  26. doi BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
    Gamal Badr
    Service of Immuno Virology, Commissariat a l Energie Atomique, Departement des Sciences du Vivant, Institut des Maladies Emergentes et Thérapies Innovantes, Unité Mixte de Recherche E1, Universite Paris Sud, Orsay, France
    Blood 111:2744-54. 2008
    B-cell-activating factor of the TNF family, (BAFF), and a proliferation-inducing ligand (APRIL) regulate B-lymphocyte survival and activation...
  27. pmc Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric symptoms
    Annie George-Chandy
    Department of Rheumatology and Inflammation Research, Gothenburg, Sweden
    Arthritis Res Ther 10:R97. 2008
    The tumour necrosis factor (TNF) family ligands BAFF (B-cell activating factor of TNF family) and APRIL (a proliferation-inducing ligand) are essential for B-cell survival and function...
  28. pmc APRIL is overexpressed in cancer: link with tumor progression
    Jerome Moreaux
    CHU Montpellier, Institute of Research in Biotherapy, Montpellier, France
    BMC Cancer 9:83. 2009
    b>BAFF and APRIL share two receptors - TACI and BCMA - and BAFF binds to a third receptor, BAFF-R. Increased expression of BAFF and APRIL is noted in hematological malignancies...
  29. doi Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus
    Van Trung Chu
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    Arthritis Rheum 60:2083-93. 2009
    Elevated levels of BAFF and APRIL are characteristic of patients with systemic lupus erythematosus (SLE). The reasons for enhanced cytokine production are not well understood...
  30. doi Clinical significance of B cell-activating factor in autoimmune pancreatitis
    Hirofumi Yamanishi
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Japan
    Pancreas 40:840-5. 2011
    Overexpression of B Cell-activating factor (BAFF) is involved in autoimmunity, but little is known about its role in autoimmune pancreatitis (AIP)...
  31. ncbi Characterization of a new member of the TNF family expressed on antigen presenting cells
    C Tribouley
    Chiron Corporation, Emeryville, CA 94608 2916, USA
    Biol Chem 380:1443-7. 1999
    ..Here we present a new member of the TNF family, tumor necrosis factor superfamily member 20 (TNFSF20) that we have identified from the expressed sequence tag (EST) database and characterized...
  32. ncbi T cell costimulation by the TNF ligand BAFF
    B Huard
    Department of Dermatology, Geneva University Medical Center, Geneva, Switzerland
    J Immunol 167:6225-31. 2001
    The TNF ligand family member BAFF (B cell activating factor belonging to the TNF family, also called Blys, TALL-1, zTNF-4, or THANK) is an important survival factor for B cells [corrected]...
  33. ncbi BAFF is a survival and maturation factor for mouse B cells
    Antonius G Rolink
    Department of Immunology, University of Basel, Basel, Switzerland
    Eur J Immunol 32:2004-10. 2002
    Human B cell-activating factor (BAFF) induces mouse surface IgM+ B cells of the immature type from bone marrow and of the immature types 1 and 2 from spleen, as well as of the mature type from spleen to increased longevity in tissue ..
  34. ncbi BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases
    Viktor Roschke
    Department of Antibody Development, Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Immunol 169:4314-21. 2002
    b>BLyS and APRIL are two members of the TNF superfamily that are secreted by activated myeloid cells and have costimulatory activity on B cells...
  35. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..b>BAFF, a member of the TNF family, is a key regulator of B cell homeostasis...
  36. ncbi Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases
    Patrizia Scapini
    Department of Pathology, University of Verona, Verona, Italy
    Blood 105:830-7. 2005
    ..human neutrophils accumulate and release remarkable amounts of soluble B-lymphocyte stimulator (BLyS) in vitro...
  37. ncbi Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival
    Anne J Novak
    Departments of Immunology, Pediatric and Adolescent Medicine, and Internal Medicine, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    Blood 100:2973-9. 2002
    ..B-lymphocyte stimulator (BLyS) is a newly identified tumor necrosis factor (TNF) family member shown to be critical for maintenance of normal B-..
  38. ncbi Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation
    Ho Min Kim
    Department of Biological Science, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Nat Struct Biol 10:342-8. 2003
    B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACI and BAFF-R...
  39. ncbi HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 176:3931-41. 2006
    ..Chronic activation of B cells through this CD40-independent pathway could impair protective T cell-dependent Ab responses by inducing immune exhaustion...
  40. ncbi The role of the BAFF/APRIL system on T cell function
    Fabienne Mackay
    Department of Immunology and Inflammation, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Semin Immunol 18:284-9. 2006
    b>BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas...
  41. ncbi BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome
    Jacques Olivier Pers
    Brest University Medical School, Brest, France
    Arthritis Rheum 56:1464-77. 2007
    ..The purpose of this study was to track the repopulation of B cell subsets in PB as well as their subsequent homing into SGs in patients with primary SS treated with rituximab...
  42. ncbi Identification of new splice variants of the genes BAFF and BCMA
    Anna S Smirnova
    Immunogenetics Division, Department of Pediatrics, Universidade Federal de Sao Paulo, R Loefgreen 1235, 04040 031 São Paulo, SP, Brazil
    Mol Immunol 45:1179-83. 2008
    The TNF superfamily ligands BAFF and APRIL and receptors BCMA, TACI and BAFF-R play an important role in the regulation of B cell immunity...
  43. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion...
  44. pmc TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation
    X Z Xia
    Department of Inflammation, Amgen, Thousand Oaks, California 91320 1799, USA
    J Exp Med 192:137-43. 2000
    ..The identification and characterization of the receptor for TALL-1 provides useful information for the development of a treatment for B cell-mediated autoimmune diseases such as systemic lupus erythematosus...
  45. pmc B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
    H B Shu
    Department of Immunology, National Jewish Medical and Research Center and University of Colorado School of Medicine, 1400 Jackson Street, K516c, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 97:9156-61. 2000
    ..The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases...
  46. ncbi Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS
    Y Wu
    Department of Molecular Biology, Human Genome Sciences, Inc, Rockville, Maryland 20850, USA
    J Biol Chem 275:35478-85. 2000
    An expression cloning approach was employed to identify the receptor for B-lymphocyte stimulator (BLyS) and identified the tumor necrosis factor receptor superfamily member TACI as a BLyS-binding protein...
  47. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R)...
  48. ncbi BLyS and BLyS receptor expression in non-Hodgkin's lymphoma
    Javier Briones
    Division of Oncology, Stanford University Medical Center, Stanford, CA 94305 5151, USA
    Exp Hematol 30:135-41. 2002
    b>B Lymphocyte Stimulator (BLyS) protein and its receptor are new members of the tumor necrosis factor family, with specific effects exclusively on B cells...
  49. ncbi Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis
    A Kawasaki
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Genes Immun 3:424-9. 2002
    Recent studies indicated a substantial role of BLyS (BAFF, TNFSF13B) in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in humans and in animal models...
  50. ncbi Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
    Andrew Craxton
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Blood 101:4464-71. 2003
    ..BCR-activated B-cell proliferation, indicating a requirement for at least one of the known TACI ligands, BAFF and/or APRIL...
  51. ncbi BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
    Nathaniel C Gordon
    Department of Protein Engineering, Genentech, Inc, One DNA Way, South San Francisco, California 94080, USA
    Biochemistry 42:5977-83. 2003
    BAFF/BLyS, a member of the tumor necrosis family (TNF) superfamily of ligands, is a crucial survival factor for B cells...
  52. pmc DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF
    Amanda L Gavin
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:38220-8. 2003
    The tumor necrosis family member BAFF is limiting for the survival of follicular B lymphocytes, but excessive BAFF signaling can lead to autoimmunity, suggesting that its activity must be tightly regulated...
  53. pmc EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 171:5215-24. 2003
    ..By showing that LMP1 triggers T cell-independent CSR, our findings suggest that EBV could play an important role in the pathogenesis of disorders with aberrant IgG, IgA, and/or IgE production...
  54. ncbi BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex
    Hidenori Hase
    Division of Immunology, Institute for Medical Science, and Department of Pathology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Blood 103:2257-65. 2004
    The tumor necrosis factor (TNF)-like ligand BAFF/BLyS (B-cell activating factor of the TNF family/B-lymphocyte stimulator) is a potent B-cell survival factor, yet its functional relationship with other B-cell surface molecules such as ..
  55. ncbi B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations
    William Stohl
    Los Angeles County University of Southern California Medical Center, and University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Arthritis Rheum 48:3475-86. 2003
    To assess the overexpression of B lymphocyte stimulator (BLyS) over time in patients with systemic lupus erythematosus (SLE).
  56. ncbi Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL
    Bing He
    Departments of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Immunol 172:3268-79. 2004
    ..We show in this study that non-Hodgkin's lymphoma (NHL) B cells express B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), two powerful B cell-activating molecules usually expressed by myeloid ..
  57. pmc BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
    Jerome Moreaux
    Institut National de la Santé et de la Recherche Médicale U475 and Unité de Thérapie Cellulaire, Centre Hospitalier Universitaire Montpellier, Hopital St Eloi, France
    Blood 103:3148-57. 2004
    ..identified overexpression of 2 receptors for a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF) in malignant plasma cells compared with normal plasma cells...
  58. ncbi Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding
    Sarah G Hymowitz
    Department of Protein Engineering, Molecular Oncology, Medicinal Chemistry, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 280:7218-27. 2005
    ..TACI binds two ligands, APRIL and BAFF, with high affinity and contains two cysteine-rich domains (CRDs) in its extracellular region; in contrast, BCMA ..
  59. ncbi Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines
    Junko Ohata
    Division of Hematology Oncology, University of California, San Diego, La Jolla 92093, USA
    J Immunol 174:864-70. 2005
    ..joints in osteoarthritis in that they stained with mAb specific for the B cell-activating factor of the TNF family (BAFF; also called BLyS)...
  60. pmc The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
    Jerome Moreaux
    INSERM U475, 99, Rue Puech Villa, 34197 Montpellier Cedex 5, France
    Blood 106:1021-30. 2005
    B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have been shown to promote multiple myeloma (MM) cell growth...
  61. ncbi BAFF augments certain Th1-associated inflammatory responses
    Andrew P R Sutherland
    Arthritis and Asthma Research Program, Garvan Institute of Medical Research, Sydney, Australia
    J Immunol 174:5537-44. 2005
    B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders...
  62. ncbi Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome
    Malin V Jonsson
    Department of Odontology Oral Pathology and Forensic Odontology, University of Bergen, Bergen, Norway
    J Clin Immunol 25:189-201. 2005
    b>B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of the tumour necrosis factor superfamily...
  63. pmc BLyS and APRIL in rheumatoid arthritis
    Thorsten M Seyler
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 115:3083-92. 2005
    The cytokines B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) enhance autoimmune disease by sustaining B cell activation...
  64. ncbi BAFF is elevated in serum of patients with Wegener's granulomatosis
    Markus Krumbholz
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Autoimmun 25:298-302. 2005
    b>BAFF (B-cell activating factor of the TNF family) plays a crucial role in B-cell survival...
  65. pmc B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia
    Sherine F Elsawa
    Division of Hematology and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Blood 107:2882-8. 2006
    ..Many of the mechanisms leading to this disease are not yet known. B-lymphocyte stimulator (BLyS) is a TNF family member that is critical for maintenance of normal B-cell development and homeostasis...
  66. pmc B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels
    Christopher E Collins
    Division of Rheumatology, Department of Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, CA 90033, USA
    Arthritis Res Ther 8:R6. 2006
    Considerable evidence points to a role for B lymphocyte stimulator (BLyS) overproduction in murine and human systemic lupus erythematosus (SLE)...
  67. ncbi Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor)
    Teresa G Cachero
    Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Biochemistry 45:2006-13. 2006
    The oligomeric state of BAFF (B cell activing factor), a tumor necrosis factor (TNF) family cytokine that plays a critical role in B cell development and survival, has been the subject of recent debate...
  68. pmc Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas
    Lingchen Fu
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 107:4540-8. 2006
    ..BLyS binds to 3 TNF-R receptors, TACI, BCMA, BAFF-R, to regulate B-cell survival, differentiation, and proliferation...
  69. ncbi Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy
    Keiko Yoshimoto
    Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama 350 8550, Japan
    Int Immunol 18:1189-96. 2006
    B cell-activating factor of the tumor necrosis factor (TNF) family, or BAFF, is mainly produced in monocytes and dendritic cells, and indispensable for proliferation, differentiation and survival of B cells...
  70. pmc A role for BLyS in the activation of innate immune cells
    Sook Kyung Chang
    Department of Immunology, Guggenheim 4, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Blood 108:2687-94. 2006
    B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily. Although BLyS costimulates adaptive immune cells, the ability of BLyS to stimulate innate immune cells has not been described...
  71. ncbi Mutational analysis of human BLyS in patients with common variable immunodeficiency
    Claretta Gioia Losi
    Istituto di Medicina Molecolare Angelo Nocivelli, Clinica Pediatrica, Universita di Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy
    J Clin Immunol 26:396-9. 2006
    b>BLyS, a TNF family member, is crucial for B cell proliferation and differentiation by acting through its three receptors, TACI, BCMA and BAFF-R...
  72. ncbi BAFF, APRIL and their receptors: structure, function and signaling
    Claudia Bossen
    Biochemistry Department, University of Lausanne, Boveresses 155, CH 1066 Epalinges, Switzerland
    Semin Immunol 18:263-75. 2006
    b>BAFF, APRIL and their receptors play important immunological roles, especially in the B cell arm of the immune system...
  73. ncbi BAFF, APRIL and human B cell disorders
    Stuart G Tangye
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Semin Immunol 18:305-17. 2006
    ..b>BAFF has been identified as a critical regulator of B cell development and differentiation...
  74. ncbi BLyS and B cell homeostasis
    Robert T Woodland
    Department of Molecular Genetics and Microbiolgy, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Immunol 18:318-26. 2006
    Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF)...
  75. ncbi Prognostic significance of serum B-lymphocyte stimulator in Hodgkin's lymphoma
    Yasuhiro Oki
    Haematologica 92:269-70. 2007
    B-lymphocyte stimulator (BLyS) plays a critical role in the survival of B-lymphocytes. In 50 patients with Hodgkin's lymphoma BLyS levels were higher in newly diagnosed patients (median 2.0 ng/mL, range <0.3-56...
  76. ncbi Divergent effects of BAFF on human memory B cell differentiation into Ig-secreting cells
    Jaime R Darce
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Graduate School, 200 First Street Southwest, Rochester, MN 55905, USA
    J Immunol 178:5612-22. 2007
    B cell-activating factor belonging to the TNF family (BAFF) plays a critical role in B cell maturation, yet its precise role in B cell differentiation into Ig-secreting cells (ISCs) remains unclear...
  77. ncbi Elevated serum BAFF levels in patients with autoimmune hepatitis
    Kiyoshi Migita
    Clinical Research Center, National Nagasaki Medical Center, Kubara 2 1001 1, Omura 856 8562, Japan
    Hum Immunol 68:586-91. 2007
    ..B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and ..
  78. ncbi Elevated serum APRIL levels in patients with systemic sclerosis: distinct profiles of systemic sclerosis categorized by APRIL and BAFF
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 34:2056-62. 2007
    Elevated serum concentrations of B cell-activating factor belonging to the tumor necrosis factor family (BAFF) are found in systemic sclerosis (SSc) and are associated with the severity of skin sclerosis...
  79. ncbi Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model
    Paola Neri
    Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Clin Cancer Res 13:5903-9. 2007
    B-cell-activating factor (BAFF) is a tumor necrosis factor superfamily member critical for the maintenance and homeostasis of normal B-cell development...
  80. ncbi TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts
    Claudia Bossen
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Blood 111:1004-12. 2008
    The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers...
  81. ncbi Expression of BAFF and BAFF-R in the synovial tissue of patients with rheumatoid arthritis
    K Nakajima
    Division of Rheumatic Diseases, International Medical Centre of Japan, Tokyo
    Scand J Rheumatol 36:365-72. 2007
    The elevated expression of B-cell-activating factor belonging to the TNF family (BAFF) is associated with systemic autoimmune disease, including rheumatoid arthritis (RA)...
  82. pmc Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas
    Vassiliki Pelekanou
    Laboratory of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, 71003, Greece
    BMC Cancer 8:76. 2008
    ..Among these members, BAFF and APRIL (CD257 and CD256 respectively) gained an increased interest, in view of their role in cell protection, differentiation ..
  83. pmc Signaling pathways for B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in human placenta
    Daudi L Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    Am J Pathol 172:1303-11. 2008
    ..superfamily (TNFSF) contains two soluble ligands that are involved in B lymphocyte development, BAFF (B cell activating factor, BlyS, TALL-1, CD257, TNFSF13B) and APRIL (a proliferation inducing ligand, CD256, TNFSF13)...
  84. pmc B lymphocyte stimulator regulates adaptive immune responses by directly promoting dendritic cell maturation
    Sook Kyung Chang
    Department of Immunology, College of Medicine, Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 180:7394-403. 2008
    b>B lymphocyte stimulator (BLyS) is a well-known direct costimulator of adaptive immune cells, particularly B lineage cells. However, we have reported recently that BLyS is also able to activate monocytes...
  85. ncbi Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis
    Silvia Bosello
    Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
    J Rheumatol 35:1256-64. 2008
    To determine whether levels of B cell activating factor (BAFF), a member of the tumor necrosis factor family, relate to autoantibody levels, disease activity, and response to treatment in patients with early rheumatoid arthritis (ERA).
  86. pmc Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF
    Weifeng Xu
    Department of Pathology and Laboratory Medicine, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    J Immunol 181:276-87. 2008
    ..Subsequent IgG and IgA production was enhanced by BAFF (B cell-activating factor of the TNF family), an innate mediator released by TLR3-expressing mucosal dendritic ..
  87. doi Correlation of expression levels of BLyS and its receptors with multiple myeloma
    Shaoqing Ju
    Laboratory Medicine Center, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu Province 226001, PR China
    Clin Biochem 42:387-99. 2009
    To measure the expression levels of B-lymphocyte stimulator (BLyS) and its receptors in multiple myeloma (MM), and to investigate the relationship between them.
  88. pmc Serum BLyS levels increase after rituximab as initial therapy in patients with follicular Grade 1 non-Hodgkin lymphoma
    Stephen M Ansell
    Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Hematol 84:71-3. 2009
    Serum B-lymphocyte stimulator (BLyS) levels are elevated in a subset of non-Hodgkin lymphoma (NHL) patients, particularly those with a family history of B-cell malignancies or a polymorphism in the BLyS gene...
  89. pmc Local release of B cell-activating factor of the TNF family after segmental allergen challenge of allergic subjects
    Atsushi Kato
    Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    J Allergy Clin Immunol 123:369-75. 2009
    ..Local production of IgA and IgE in the airways has been proposed to be an important event in both immune protection from pathogens and the pathogenesis of airway allergic diseases...
  90. pmc Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma
    Anne J Novak
    Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 69:4217-24. 2009
    Elevated B-cell-activating factor (BAFF; TNFSF13B) levels have been found in patients with B-cell malignancies and autoimmune diseases, suggesting that it may play a pathogenic role...
  91. doi Interleukin-10 and interferon-gamma up-regulate the expression of B-cell activating factor in cultured human promyelocytic leukemia cells
    Lin Zhou
    Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shaghai, PR China
    Exp Mol Pathol 87:54-8. 2009
    B-cell activating factor (BAFF) is a potent cell-survival factor, expressed in many hematopoietic cells, for B-cell maturation and activation. It is involved in pathogenesis of autoimmune disorders and B-cell malignancies...
  92. pmc Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes
    N Acevedo
    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
    Clin Exp Immunol 157:282-90. 2009
    ..Ig)E and IgG confer protective immunity and here we sought to investigate in an endemic population whether LIG4, TNFSF13B and IRS2 genes influence IgE and IgG levels against Ascaris and the ABA-1 allergen as a putative resistance ..
  93. doi Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development
    Vassilia Ismini Alexaki
    Department of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, Greece
    J Immunol 183:5948-56. 2009
    ..In this paper, we report the differential expression of TNF-superfamily members B cell activating factor of the TNF Family (BAFF), a proliferation inducing ligand (APRIL), and TNF-like weak inducer of apoptosis ..
  94. doi Reverse signaling through BAFF differentially regulates the expression of inflammatory mediators and cytoskeletal movements in THP-1 cells
    Sung Tak Jeon
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu, Korea
    Immunol Cell Biol 88:148-56. 2010
    ..b>BAFF has been reported to have important functions in B-cell survival through forward signaling, but the presence of ..
  95. doi Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia
    Stefano Molica
    Medical Oncology Unit, Hematology Oncology Department, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Eur J Haematol 85:314-20. 2010
    ..heavy chain variable region (IgVH), ZAP-70 and CD38 expression] and serum levels of B cell-activating factor (BAFF of the TNF family) by evaluating the impact of these variables on the time to first treatment (TFT) in a series of ..
  96. doi Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS
    Michael R Pranzatelli
    National Pediatric Myoclonus Center and Neuroimmunology Laboratory, Southern Illinois University School of Medicine, Springfield, IL 62794 9643, USA
    Cytokine 53:384-9. 2011
    ..Serum BAFF concentration changed dramatically (even after first infusion) and inversely with B-cell depletion/repopulation and ..
  97. doi Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus
    Carolina Landolt-Marticorena
    Arthritis Centre of Excellence, Division of Genetics and Development, and the Division of Health Care and Outcomes Research, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 38:642-51. 2011
    To examine the relationship between interferon-α (IFN-α) and dysregulation of B cell activation factor (BAFF) and specific B cell phenotypes in systemic lupus erythematosus (SLE).
  98. doi Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma
    M Fragioudaki
    Department of Hematology, University Hospital of Heraklion, Heraklion, Greece
    Leuk Res 36:1004-8. 2012
    B-cell activating factor (BAFF) is a B-cell growth factor...
  99. pmc Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L
    Montserrat Cols
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 188:6071-83. 2012
    ..We found that the CLL stroma included microvascular endothelial cells (MVECs) expressing BAFF and APRIL, two TNF family members related to the T cell-associated B cell-stimulating molecule CD40L...
  100. doi BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells
    G Xu
    Laboratory Medicine Center, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China
    Cytokine 60:505-13. 2012
    B-Lymphocyte stimulator (BLyS), a member of tumor necrosis factor superfamily, is a potent co-activator of B cells in vitro, and in vivo induces B cell proliferation and immunoglobulin secretion...
  101. doi BAFF expression correlates with idiopathic inflammatory myopathy disease activity measures and autoantibodies
    Consuelo M López De Padilla
    Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Rheumatol 40:294-302. 2013
    ..To investigate B cell survival cytokine messenger RNA (mRNA) levels as biomarkers of idiopathic inflammatory myopathies (IIM)...

Research Grants65

  1. Jeffrey C Rathmell; Fiscal Year: 2014
    ..Importantly, B cells from SLE-prone BAFF-transgenic mice were highly glycolytic immediately upon isolation, suggesting that this metabolic transition occurs ..
  2. John C Cambier; Fiscal Year: 2014
    ..that SHIP-1 mediates the unresponsiveness of anergic B cells to antigen as well as to the survival factor BAFF, and propose to test this possibility in aim 1...
  3. Judith A James; Fiscal Year: 2016
    ..a spectrum of pre-clinical lupus collections, 2) evaluate the role of IL1 receptor antagonist:IL1beta ratios and BLyS levels, as well as other peripheral cytokine or chemokine measurements, in the transition from preclinical ..
  4. David V Serreze; Fiscal Year: 2016
    ..populations, including those in NOD islets, can potentially be deleted through use of agents inhibiting the BAFF/APRIL survival factors rather than anti-CD20...
  5. Robert P Schleimer; Fiscal Year: 2016
    ..We have discovered that nasal polyp tissue contains very high levels of B lymphocytes, the B cell activator BAFF, the B cell chemokines CXCL12 and CXCL13, IgA and IgE...
  6. TIMOTHY L MANSER; Fiscal Year: 2014
    ..In this application, we propose to test this hypothesis by generating human IL-7 and human BLyS (BAFF) expressing NSG mice for use as recipients for UCB HSCs...
  7. B-Cell Tolerance Mechanisms in Human SLE
    JENNIFER HOWITT ANOLIK; Fiscal Year: 2013
    ..g. BAFF-B cell activator of the TNF family) relative to the numbers of transitional B cells emerging from the bone marrow (..
  8. CHRISTINE MOREL COQUERY; Fiscal Year: 2014
    ..B Cell Maturation Antigen (BCMA) is an important receptor that binds two ligands: BAFF and APRIL...
  9. Impact of regulatory T cells on human peripheral B cell tolerance
    Eric Meffre; Fiscal Year: 2013
    ..patients, who pointed to a potential role for regulatory T (Treg) cells and serum B-cell activating factor (BAFF) in the removal of developing autoreactive B cells in the periphery (6)...
  10. Loren D Erickson; Fiscal Year: 2016
    ..receptor family and was first described by our group as a critical receptor on PCs that, upon binding its ligands BAFF and APRIL, mediates their long-term survival in the bone marrow (BM)...
  11. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2012
    ..determine on which cell types TLRs need to be expressed to promote RF B cell activation;and d) test the roles of BAFF/APRIL in promoting differentiation, class-switch and mutation...
  12. COGNATE ACTIVATION OF B-LYMPHOCYTES
    Randolph J Noelle; Fiscal Year: 2013
    ..role of BCR affinity in B cell fate, 2) Developed new strategies to isolate and study Bmem, 3) Resolved the role of BAFF family members in Bmem and PC survival;4) Shown that Bmem can be selectively primed relative to PCs, 5) Identified ..
  13. Jamie L Renbarger; Fiscal Year: 2016
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  14. B-Lymphocyte Repertoire Remodeling for Transplantation Tolerance
    Hooman Noorchashm; Fiscal Year: 2010
    ..the TR`follicular (FO) B-cell developmental checkpoint is regulated by the dominant B lymphocyte survival factor, BLyS/BAFF...
  15. Jolan E Walter; Fiscal Year: 2016
    ..indicated impaired receptor editing (a disruption of central B cell tolerance) and increased levels of B cell activating factor (BAFF) secondary to lymphopenia that might contribute to the rescue of self-reactive B cell in the ..
  16. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..We have discovered that nasal polyp tissue contains very high levels of B lymphocytes, the B cell activator BAFF, the B cell chemokines CXCL12 and CXCL13, IgA and IgE...
  17. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..Studies in this grant application will define a novel function for Btk in signaling through B cell activating factor receptor (BAFF-R)...
  18. IKKa-Dependent Negative Feedback Control of Non-Canonical NF-kB Activation
    Genhong Cheng; Fiscal Year: 2012
    ..variety of cell types, non-canonical NF-:B signaling is activated over hours by a select group of receptors such as BAFF, LT2R, CD40 and RANK on a limited number of cell types such as B-cells, fibroblasts, and macrophages...
  19. Establishing and characterizing BAFF RFP reporter and BAFF knockin mice
    Edward A Clark; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): BAFF (B cell activating factor, BLyS, TNFSF13B) is a TNF-family cytokine produced by a number of cell types such as dendritic cells (DCs), monocytes, neutrophils, T and B cells and stromal cells...
  20. Effect of BAFF on threshold of B cell tolerance
    David Nemazee; Fiscal Year: 2010
    ..Elevated levels of the B cell survival cytokine BAFF are associated with lupus and SS in both humans and experimental animals...
  21. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..Engagement of TACI by its ligands B cell activating factor (BAFF) or a proliferation inducing ligand (APRIL) up-regulate the expression of activation-induced ..
  22. Tageting BAFF and BAFF-Induced Non-Canonical NF-kB Pathways for Enhancing Mantle
    Jianguo Tao; Fiscal Year: 2013
    ..Furthermore, our preliminary data has shown that BAFF (B cell activating factor belonging to the tumor necrosis factor [TNF] family) activates this pathway and plays a critical role in ..
  23. Anne Davidson; Fiscal Year: 2014
    ..Engagement of TLRs induces both IFN1 that fosters plasma cell maturation and BAFF that enhances B cell survival and class switching;disease can then be propagated by T cell independent mechanisms ..
  24. Emiko Mizoguchi; Fiscal Year: 2015
    ..they developed both in antigen-independent manner and in SLPI (secretory leukocyte protease inhibitor) and BAFF (receptor of B cell activation factor from the TNF family)-dependent manners...
  25. Pathways of B cell differentiation into plasma cells
    Loren D Erickson; Fiscal Year: 2011
    ..that the long-term survival of PCs produced de novo from PCpre is controlled by interactions with the cytokines BLyS and IL-6...
  26. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..Cytokines CXCL10, CXCL11, IL-7, RANTES and BAFF are induced 337, 45, 128, 84 and 119 fold, respectively, in synchronously infected ECs by 24 hrs p.i...
  27. Barbara J Vilen; Fiscal Year: 2014
    ..In vivo and in vitro, the accumulation of ICs heightens BAFF secretion...
  28. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..the relative role of CNS localized Ag versus chemokines in regulating ASC retention and 4) demonstrate that BAFF is the major survival factor for ASC within the CNS...
  29. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2012
    ..B cell function is regulated by B cell receptor, BCR, as well as other B cell specific receptors like BAFF-R...
  30. Regulation of the anti-phospholipid response in SLE
    Anne Davidson; Fiscal Year: 2009
    ..Engagement of TLRs induces both IFN&#945;that fosters plasma cell maturation and BAFF that decreases the stringency for B cell negative selection and enhances B cell survival and class switching...
  31. Peter Buchwald; Fiscal Year: 2016
    ..similar mechanism can be found for other members of the TNF superfamily (in particular, OX40[unreadable]OX40L, BAFF-R[unreadable]BAFF, RANK[unreadable]RANKL, 4-1BB[unreadable]4- 1BBL) and whether it can be used to identify specific ..
  32. David M Allman; Fiscal Year: 2016
    ..role of newly formed and long-lived BM PCs in antibody-mediated autoimmunity;and 3) Define the roles of IL-5 and BAFF family cytokines in the maintenance of TI antigen-induced PCs...
  33. Bonnie B Blomberg; Fiscal Year: 2014
    ..suboptimal responses in aged human B cells? B cells will be stimulated either with anti-CD40/IL-4, CpG/IL-4, or BAFF/IL-4. Possible AID down regulation will be assessed by quantitative (q) PCR...
  34. Philip J Thomas; Fiscal Year: 2016
    ..We thank the institute for selecting our study for MERIT support that allowed pursuit of the long term discovery effort of ..
  35. Kei Yasuda; Fiscal Year: 2015
    ..stage in B cell development is synergistically controlled by both B cell receptor (BCR) signaling and B lymphocyte stimulator (BLyS) receptor signaling, we hypothesize that IRF5 is involved in either B cell receptor signaling or ..
  36. John W Sleasman; Fiscal Year: 2016
    ..cytokines, extent of macrophage activation, and capacity of neonatal monocytes/macrophages to produce BAFF and APRIL following activation via Toll-like receptors...
  37. Lymphocyte Functions in the Injured Spinal Cord
    Phillip G Popovich; Fiscal Year: 2013
    ..Specifically, we will document spatiotemporal induction patterns and sources of BAFF and APRIL after SCI...
  38. Mechanisms of B Cell Survival and Death
    Roberta Pelanda; Fiscal Year: 2011
    ..We propose that the NF-KBpathway, BAFF-R signaling and the Bcl-2 family properly translate B cell antigen receptor signaling to regulate cellular lifespan ..
  39. Andrei E Medvedev; Fiscal Year: 2014
    ..These advances would be of key importance for basic immunology of SLE, and for improving public health of lupus patients in the U.S. ..
  40. Regulation of humoral immunity by NKT cells
    Mark L Lang; Fiscal Year: 2013
    ..and perhaps important for the induction of primary Ab responses and memory B cells (iii) The TNF family member BAFF (B cell-activating factor) that promotes development and survival of plasma cells...
  41. Role of TACI in B Cell Function and Transformation
    RICHARD BRAM; Fiscal Year: 2007
    ..BAFF (also called BLyS, THANK, TALL, and zTNF4) was first identified in 1999 as an orphan TNF homologue with B-lymphocyte stimulatory properties,..
  42. Toll-like receptor signaling in the generation of B1b cell memory
    Kishore R Alugupalli; Fiscal Year: 2012
    ..found that TLR and BCR signaling pathways synergize to upregulate BR3 and TACI, the major receptors for B Lymphocyte Stimulator (BLyS, also known as BAFF), on B1b cells in vitro...
  43. Marco Colonna; Fiscal Year: 2014
    ..We also demonstrate that NK-22 cells secrete BAFF, a soluble factor that enhances B cell responses...
  44. B Cells and Autoimmunity
    John C Cambier; Fiscal Year: 2010
    ..aim entitled "Does the SHIP-1/Dok-1 pathway mediate anergic B cell hyporesponsiveness to antigen, CXCL12 and BAFF, and, if so, how? Studies will test the concept of a mobile PtdIns3,4,5P3 scavenger complex (mPsc) that consists of ..
  45. L2DTL Function in Maintaining Genomic Stability during Drosophila Development
    CATHERINE SILVER KEY; Fiscal Year: 2010
    ..organism, this proposal will focus on identifying and characterizing fly stocks with mutations in the l(2)dtl gene...
  46. Michael R Verneris; Fiscal Year: 2016
    ..Lastly, we have found that LTi cells express TNF-superfamily molecules (including OX40L, CD70 LTa1b2 and BAFF) and hypothesize that they costimulate T, B and NK cell activation and proliferation...
  47. TAREK A ABBAS; Fiscal Year: 2014
    ..Cdt2/DTL, a WD-repeat containing protein associates with CRL4 (CRL4-Cdt2) and functions as a substrate recognition factor ..
  48. BCR signaling during B cell development and maintenance
    MICHAEL CRAIG CARROLL; Fiscal Year: 2012
    ..has demonstrated that the maintenance of mature B cells requires, apart from an NFicB-mediated signal through the BAFF-R (Sasaki et al., 2006), a maintenance signal through the BCR, involving the Igo/p cytoplasmic tail (Kraus et al...
  49. Stefanie Sarantopoulos; Fiscal Year: 2014
    ..The long-term goal of this research project is to understand the role of B cell Activating Factor of the TNF family (BAFF) and its associated signaling pathways...
  50. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..We will test the hypothesis that interruption of B cell maturation by TACI-lg (a fusion protein antagonist of BAFF and APRIL) will reduce acute rejection rates and improve outcome in highly sensitized renal transplant recipients...
  51. Targeting Placental Pathophysiology in IUGR and Preeclampsia
    Seth Guller; Fiscal Year: 2010
    ..We thank the NIH for considering two additional years of funding for our now long-standing studies examining placental ..
  52. HIVRAD: Structural approaches to vaccine development
    Ellis Reinherz; Fiscal Year: 2009
    ..trimeric fragments as well as exploiting "miniprotein" designs including fusion to protein G B1 domain, C3d or Blys proteins in E. coli and Pichia, among other expression systems...
  53. Ali Naji; Fiscal Year: 2016
    ..the key regulatory pathway of B cell survival, life-span and selection: the TNF-related cytokine known as BLyS/BAFF. It was recently recognized that this cytokine regulates antigen mediated negative selection of newly emerging "..
  54. Timothy P Bender; Fiscal Year: 2014
    ..that c-Myb is crucial for peripheral B cell homeostasis and that c-Myb deficient B cells are hyporesponsive to BAFF, displaying both reduced expression of BAFF-R and increased nuclear distribution of PKC-(...
  55. Muscle-based Tissue Engineering to Improve Bone Healing
    Johnny Huard; Fiscal Year: 2010
    ..We would like to thank NIDCR for their support during the prior funding period...
  56. Follicular dendritic cells and B cell tolerance
    Robert C Rickert; Fiscal Year: 2013
    ..antigen and immune complexes, but also respond to environmental stimuli and provide soluble factors, including BAFF, that impact late B cell differentiation...
  57. Mark J Shlomchik; Fiscal Year: 2016
    ..Similarly anti-CD20 failed to show clinical effect in SLE patients, though anti-BLyS did...
  58. Manipulating Aromaticity: characterization of an ultra-rapid insulin analog
    BRUCE HILL FRANK; Fiscal Year: 2013
    ..Thermalin Diabetes, LLC has an exclusive license to ChaB24- related IP, which is owned by CWRU. We thank the Study Section for its guidance.
  59. Roberta Pelanda; Fiscal Year: 2014
    ..b>BAFF isan important homeostatic factor for B cells both in mice and in humans...
  60. Role of BAFF in regulation of B cell peripheral tolerance
    Neda Nikbakht; Fiscal Year: 2012
    ..The project described in this fellowship application centers on understanding the role of the cytokine BAFF in the regulation of DNA-reactive B cells that enter the germinal center B cell response...
  61. Intestinal Mucosal Immunity
    Margaret E Conner; Fiscal Year: 2013
    ..We find that a mutation in the B cell activating factor (BAFF) signaling pathway also results in the ablation of B cell activation, suggesting a potential link ..
  62. MUSCLE CELLS MEDIATED GENE THERAPY FOR INCONTINENCE
    Michael Chancellor; Fiscal Year: 2005
    ..We were extremely productive during the initial ROl grant funding period and we would like to thank NIDDK for their support. All key objectives of the previous grant were successfully completed...
  63. AGE ASSOCIATED CHANGES IN B LYMPHOCYTE FUNCTION
    Subbarao Bondada; Fiscal Year: 2005
    ..Also, B-cell macrophage interactions required for TI responses may involve the macrophage derived cytokine BLyS and its B-cell receptors, TACI and BCMA, which may be dysfunctional in the neonate...
  64. Act1 in CD40-/BAFFR-Mediated B Cell Survival
    Xiaoxia Li; Fiscal Year: 2009
    ..CD40-CD40L and BAFF-BAFFR cytokine pathways have been shown to play essential roles in B cell survival and differentiation...