TNFRSF11A

Summary

Gene Symbol: TNFRSF11A
Description: TNF receptor superfamily member 11a
Alias: CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, tumor necrosis factor receptor superfamily member 11A, Paget disease of bone 2, loss of heterozygosity, 18, chromosomal region 1, osteoclast differentiation factor receptor, receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Species: human

Top Publications

  1. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
  2. ncbi Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    Patricia Collin-Osdoby
    Department of Biology and Division of Bone and Mineral Research, Washington University, St Louis, MO 63130, USA
    Circ Res 95:1046-57. 2004
  3. pmc Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis
    Han Kyoung Choi
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    Cell Res 23:524-36. 2013
  4. doi Hypoxia induces RANK and RANKL expression by activating HIF-1α in breast cancer cells
    Zhen Ning Tang
    Breast Disease Center, Southwest Hospital, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, PR China
    Biochem Biophys Res Commun 408:411-6. 2011
  5. ncbi Genetic linkage of familial expansile osteolysis to chromosome 18q
    A E Hughes
    Department of Medical Genetics, Queen s University of Belfast, UK
    Hum Mol Genet 3:359-61. 1994
  6. ncbi A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    Nature 390:175-9. 1997
  7. ncbi Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:20551-5. 1998
  8. ncbi The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
    L Galibert
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 273:34120-7. 1998
  9. ncbi RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
    N Nakagawa
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Tochigi, Japan
    Biochem Biophys Res Commun 253:395-400. 1998
  10. ncbi Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999

Research Grants

  1. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
  3. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
  4. Ginger Extracts in the Prevention of Metabolic Bone Disease
    LAURA ELIZABETH WRIGHT; Fiscal Year: 2011
  5. Lionel B Ivashkiv; Fiscal Year: 2016
  6. Hyeong Reh Choi Kim; Fiscal Year: 2016
  7. Bin Wang; Fiscal Year: 2015
  8. Rajaram Gopalakrishnan; Fiscal Year: 2014
  9. Regulation of Myeloid Development and Function by II-4
    Achsah D Keegan; Fiscal Year: 2010
  10. Statistical methods for assessing copy number variation in SNP arrays
    Robert B Scharpf; Fiscal Year: 2012

Detail Information

Publications331 found, 100 shown here

  1. pmc Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:687-94. 1994
    ..TEA, 1-10 mM) produced a concentration-dependent inhibition of the effect of cromakalim with the rank order of potency (EC50 in parentheses): glibenclamide (0.64 microM) >> 4-AP (1.11 mM) > TEA (6.6 mM)...
  2. ncbi Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    Patricia Collin-Osdoby
    Department of Biology and Division of Bone and Mineral Research, Washington University, St Louis, MO 63130, USA
    Circ Res 95:1046-57. 2004
    ..One emerging area in vascular biology involves the RANKL/RANK/OPG system, molecules of the tumor necrosis factor-related family recently discovered to be critical regulators of ..
  3. pmc Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis
    Han Kyoung Choi
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    Cell Res 23:524-36. 2013
    The receptor activator of NF-κB (RANK) and immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors are essential factors involved in regulating osteoclast formation and bone remodeling...
  4. doi Hypoxia induces RANK and RANKL expression by activating HIF-1α in breast cancer cells
    Zhen Ning Tang
    Breast Disease Center, Southwest Hospital, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, PR China
    Biochem Biophys Res Commun 408:411-6. 2011
    Receptor activator of NF-κB (RANK) and RANK ligand (RANKL) are known to play an important role in the development and progression of breast cancer...
  5. ncbi Genetic linkage of familial expansile osteolysis to chromosome 18q
    A E Hughes
    Department of Medical Genetics, Queen s University of Belfast, UK
    Hum Mol Genet 3:359-61. 1994
    ..1-q22. Mapping a new locus for a gene involved in regulation of bone metabolism may also have implications in the study of Paget's disease of bone which is a common related bone dysplasia...
  6. ncbi A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    Nature 390:175-9. 1997
    ..Here we report the characterization of RANK (for receptor activator of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the ..
  7. ncbi Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 273:20551-5. 1998
    ..The receptor activator of NF-kappaB (RANK), a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and ..
  8. ncbi The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
    L Galibert
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 273:34120-7. 1998
    Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells...
  9. ncbi RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
    N Nakagawa
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Tochigi, Japan
    Biochem Biophys Res Commun 253:395-400. 1998
    ..ODF binds directly to osteoclast progenitors, suggesting the presence of a membrane-bound receptor for ODF (ODFR) on the cells...
  10. ncbi Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
    B G Darnay
    Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 274:7724-31. 1999
    ..We have previously shown that the cytoplasmic domain of receptor activator of NF-kappaB (RANK) interacts with TRAF2, TRAF5, and TRAF6 and that its overexpression activates NF-kappaB and JNK pathways...
  11. pmc RANK is essential for osteoclast and lymph node development
    W C Dougall
    Immunex Corporation, Seattle, Washington 98101 USA
    Genes Dev 13:2412-24. 1999
    The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice...
  12. ncbi Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
    A E Hughes
    Department of Medical Genetics, The Queen s University of Belfast, Belfast, UK
    Nat Genet 24:45-8. 2000
    ..The gene encoding receptor activator of nuclear factor-kappa B (RANK; ref. 5), TNFRSF11A, maps to this region. RANK is essential in osteoclast formation...
  13. ncbi TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
    B R Wong
    Laboratory of Immunology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 4:1041-9. 1999
    ..These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross-talk between TRAF proteins and Src family kinases...
  14. pmc RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    J Li
    Departments of Cell Biology, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Proc Natl Acad Sci U S A 97:1566-71. 2000
    We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes...
  15. ncbi A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation
    J R Arron
    Laboratory of Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 276:30011-7. 2001
    ..We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor (TRANCE-R)/RANK, TRAF6, and c-Src...
  16. pmc Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
    Junko Mizukami
    Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Yodogawa ku, Osaka 532 8505, Japan
    Mol Cell Biol 22:992-1000. 2002
    The receptor activator of NF-kappaB (RANK) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts...
  17. ncbi Long-lived immature dendritic cells mediated by TRANCE-RANK interaction
    Isabelle Cremer
    Institut National de la Santé et de la Recherche Médicale INSERM U255, Centre de Recherches Biomedicales des Cordeliers, and Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France
    Blood 100:3646-55. 2002
    ..We have identified int-DCs that express both TRANCE (tumor necrosis factor-related activation-induced cytokine) and RANK (receptor activator of NF-kappaB) and have generated these cells from CD34(+) human progenitor cells using ..
  18. ncbi Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A gene
    Kiyoshi Nakatsuka
    Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Bone Miner Res 18:1381-5. 2003
    Three different insertion mutations in the TNFRSF11A gene affecting the signal peptide of RANK have been described...
  19. ncbi Genetic polymorphisms of OPG, RANK, and ESR1 and bone mineral density in Korean postmenopausal women
    J Y Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Calcif Tissue Int 77:152-9. 2005
    To evaluate the effects of genetic polymorphisms of OPG, RANK, and ESR1, which regulate osteoclastogenesis, on bone mineral density (BMD), a cross-sectional study was conducted in 650 Korean postmenopausal women...
  20. ncbi Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA, USA
    Hum Genet 118:568-77. 2006
    In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK (TNFRSF11A) and OPG (TNFRSF11B) genes to variations in bone mineral density (BMD), a population-based cohort with 1,120 extreme low hip BMD cases or ..
  21. pmc Biology of RANK, RANKL, and osteoprotegerin
    Brendan F Boyce
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Res Ther 9:S1. 2007
    The discovery of the receptor activator of nuclear factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a logic-based approach can identify ..
  22. ncbi RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes
    Allison P Armstrong
    Department of Hematology, Amgen Inc, Seattle, Washington 98119, USA
    Prostate 68:92-104. 2008
    ..b>RANK is essential for osteoclast differentiation, activation, and survival via its expression on osteoclasts and their ..
  23. doi Multiple genetic loci for bone mineral density and fractures
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    N Engl J Med 358:2355-65. 2008
    ..Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture...
  24. pmc Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations
    Matteo M Guerrini
    Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, Segrate 20090, Italy
    Am J Hum Genet 83:64-76. 2008
    ..RANKL and RANK (coded for by the TNFRSF11A gene) also play a role in the immune system, which raises the possibility that defects in this pathway might ..
  25. doi New sequence variants associated with bone mineral density
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:15-7. 2009
    ..These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21...
  26. doi Central control of fever and female body temperature by RANKL/RANK
    Reiko Hanada
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
    Nature 462:505-9. 2009
    ..ligand (TNFSF11, also known as RANKL, OPGL, TRANCE and ODF) and its tumour necrosis factor (TNF)-family receptor RANK are essential regulators of bone remodelling, lymph node organogenesis and formation of a lactating mammary gland...
  27. doi Genetic variations in genes encoding RANK, RANKL, and OPG in rheumatoid arthritis: a case-control study
    Gunter Assmann
    Internal Medicine I and José Carreras Research Centre, University of Saarland Medical School, Homburg Saar, Germany
    J Rheumatol 37:900-4. 2010
    ..The receptor activator of nuclear factor-kappaB (RANK) and the osteoprotegerin (OPG) cascade system have been reported to be essential in osteoclastogenesis...
  28. pmc Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
    Omar M E Albagha
    Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Nat Genet 42:520-4. 2010
    ..09 x 10(-13)) and with rs3018362 on 18q21 near the TNFRSF11A gene (P = 5.27 x 10(-13))...
  29. doi Involvement of integrin up-regulation in RANKL/RANK pathway of chondrosarcomas migration
    Chin Jung Hsu
    School of Chinese Medicine, China Medical University, Taichung, Taiwan
    J Cell Biochem 111:138-47. 2010
    ..Receptor activator of nuclear factor-kappaB ligand (RANKL) and its receptor, RANK, play a key roles in osteoclastogenesis and tumor metastasis...
  30. pmc TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women
    Yan Lu
    Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Menopause 17:1048-54. 2010
    ..The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM).
  31. doi Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases
    Daniele Santini
    Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
    J Cell Physiol 226:780-4. 2011
    Receptor activator of NFκB ligand (RANKL), RANK, and osteoprotegerin (OPG) represent the key regulators of bone metabolism both in normal and pathological conditions, including bone metastases...
  32. doi Osteoprotegerin genetic polymorphisms and age of symptom onset in ankylosing spondylitis
    Chun Huang Huang
    Department of Public Health, Chung Shan Medical University, Taiwan
    Rheumatology (Oxford) 50:359-65. 2011
    Osteoporosis is one of the recognized features of AS. It is known that RANK ligand (RANKL), which binds to RANK, can cause the activation of bone resorption...
  33. pmc Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
    Wei Tan
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California 92093, USA
    Nature 470:548-53. 2011
    ..and the upregulation of two tumour-necrosis-factor family members: receptor activator of nuclear factor-κB (RANK) ligand (RANKL) and lymphotoxin. But the source of RANKL and its role in metastasis have not been established...
  34. doi Evidence for a link between TNFRSF11A and risk of breast cancer
    Nuria Bonifaci
    Biomarkers and Susceptibility Unit, and Biomedical Research Center Network for Epidemiology and Public Health, Cancer Prevention and Control Program, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet, Barcelona 08908, Spain
    Breast Cancer Res Treat 129:947-54. 2011
    ..activator of nuclear factor-κB [Rank, encoded by the tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a) gene] is fundamental for mammary gland development in mice, regulating the expansion of stem and progenitor ..
  35. pmc Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients
    Daniele Santini
    Department of Medical Oncology, University Campus Bio Medico of Rome, Rome, Italy
    PLoS ONE 6:e19234. 2011
    Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity...
  36. doi Genome-wide association identifies three new susceptibility loci for Paget's disease of bone
    Omar M E Albagha
    Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Nat Genet 43:685-9. 2011
    ..We previously identified variants at the CSF1, OPTN and TNFRSF11A loci as risk factors for PDB by genome-wide association study...
  37. doi RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis
    Marta Palafox
    Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute IDIBELL, Barcelona, Spain
    Cancer Res 72:2879-88. 2012
    Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation of RANK pathway promotes mammary tumorigenesis in mice...
  38. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways...
  39. pmc Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury
    Shuangxin Liu
    Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
    PLoS ONE 7:e41331. 2012
    ..The ligand of receptor activator of NF-kappaB (RANKL) and receptor activator of NF-kappaB (RANK) are members of the TNF and receptor superfamilies...
  40. ncbi Expression profile of receptor activator of nuclear-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in breast cancer
    Sioned Owen
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, CF14 4XN, U K
    Anticancer Res 33:199-206. 2013
    ..Receptor activator of nuclear-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are a group of important regulators for osteoclast differentiation ..
  41. ncbi Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines
    P Fiumara
    Department of Lymphoma and Myeloma, Head and Neck Surgery, and Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 98:2784-90. 2001
    ..Previous studies reported that receptor activator of nuclear factor kappaB (NF-kappaB) (RANK), a member of the TNF receptor family, is expressed on DCs, and that RANK ligand (RANKL) enhances DC survival and ..
  42. pmc Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene
    L Palenzuela
    Centre d Investigacions en Bioquimica i Biologia Molecular CIBBIM, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Med Genet 39:E67. 2002
  43. ncbi The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
    Teiji Wada
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3 5, A 1030 Vienna, Austria
    Nat Med 11:394-9. 2005
    ..Receptor activator of NF-kappaB (RANK) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone ..
  44. ncbi RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells
    Yohann Wittrant
    Université de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Faculte de Medecine, 44035 Nantes cedex 1, France
    Int J Oncol 28:261-9. 2006
    ..undifferentiated phenotype, expressing both osteoblastic and unexpected osteoclastic markers (TRAP, cathepsin K and RANK)...
  45. doi A single-center experience in 20 patients with infantile malignant osteopetrosis
    Evelina Mazzolari
    Department of Pediatrics, University of Brescia, 25123 Brescia, Italy
    Am J Hematol 84:473-9. 2009
    ..9 months, and mean follow-up was 66.75 months. Mutations in TCIRG1, OSTM1, ClCN7, and TNFRSF11A genes were detected in nine, three, one, and one patients, respectively...
  46. pmc OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts
    L Paternoster
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 95:3940-8. 2010
    ..Several single-nucleotide polymorphisms (SNPs) have been reliably associated with areal bone mineral density (aBMD) in genome-wide association studies of mostly older subjects...
  47. pmc Follicle-stimulating hormone promotes RANK expression on human monocytes
    Joseph G Cannon
    School of Allied Health Sciences, Medical College of Georgia, Augusta, GA 30912, USA
    Cytokine 53:141-4. 2011
    ..spanning the physiological range, and then measuring the expression of receptor activator for NF-κB (RANK, a surface marker for osteoclasts) on CD14(+) cells by flow cytometry. In the absence of FSH, 3.3±0...
  48. ncbi Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis
    Michael P Whyte
    Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St Louis, Missouri 63131, USA
    J Bone Miner Res 17:26-9. 2002
    ..reported to have an identical 18-base pair tandem duplication (84dup18) in the signal peptide sequence of the TNFRSF11A gene that encodes receptor activator of nuclear factor-kappaB (RANK)...
  49. ncbi Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis
    Teresa L Johnson-Pais
    Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Bone Miner Res 18:376-80. 2003
    ..The TNFRSF11A gene encodes the receptor activator of nuclear factor-kappaB (RANK), which has been demonstrated to be essential ..
  50. doi Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men
    Delnaz Roshandel
    Arthritis Research UK, Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Bone Miner Res 25:1830-8. 2010
    The aim of this study was to determine if single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (r(2) > or = 0...
  51. ncbi TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB
    Soo Woong Lee
    National Research Laboratory for Bone Metabolism, Chosun University, Gwangju, Korea
    J Biochem Mol Biol 35:371-6. 2002
    The receptor activator of nuclear factor kappa B (RANK) is a member of the tumor necrosis factor (TNF) receptor superfamily. It plays a critical role in osteoclast differentiation, lymph node organogenesis, and mammary gland development...
  52. ncbi High-performance liquid chromatographic method for the simultaneous detection of malonaldehyde, acetaldehyde, formaldehyde, acetone and propionaldehyde to monitor the oxidative stress in heart
    G A Cordis
    University of Connecticut School of Medicine, Farmington 06030-1110
    J Chromatogr A 661:181-91. 1994
    ..acetaldehyde (ADA), acetone, and propionaldehyde (PDA), the degradation products of oxygen-derived free radicals (ODFR) and PUFA, as presumptive markers for LPO...
  53. ncbi The insulin-like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy
    S A Lieberman
    Medical Service, Department of Veterans Affairs Medical Center, Palo Alto, California
    Horm Metab Res 26:229-33. 1994
    ..years) males (OM), older females not on estrogen replacement (OFN), and older females on oral estrogen replacement (OFE). Blood was sampled for IGF-I and GHBP over 72 hours following GH administration...
  54. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
    ..3. Under control culture conditions vessels released prostaglandins in the following rank order 6-keto PGF1 alpha = PGE2 > > TXB2...
  55. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
    ..A number of bradykinin B2 antagonists selectively and reversibly attenuated the response to bradykinin. The rank order potency was Hoe 140> LysLys [Hyp3,Thi5 8,D-Phe7]-bradykinin> D-Arg[Hyp3, Thi5'8, D-Phe7]-bradykinin = D-..
  56. pmc Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bed
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 114:1541-8. 1995
    ..A rank order of vasodilator potency of ADP >> ADP-ribose >> NADP > or = NAD = adenosine was observed...
  57. pmc Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells
    J Pfeilschifter
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 110:847-53. 1993
    ..4. The rank order of potency of a series of nucleotide analogues for stimulation of phosphatidylethanol formation was UTP = ATP ..
  58. pmc Mechanism of action of the inhibitory effect of nifedipine on the growth of cultured aortic cells from spontaneously hypertensive and normotensive rats
    T Herembert
    CNRS URA 1482, Universite Rene Descartes, UFR des Saints Pères, Paris, France
    Br J Pharmacol 114:1703-9. 1995
    ..cultures nifedipine, like other dihydropyridines concentration-dependently inhibited cell proliferation; the rank order of effect (measured at a concentration of 10 microM) was nifedipine > nisoldipine > nitrendipine ..
  59. pmc Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileum
    H Reddy
    Syntex Discovery Research, Institute of Pharmacology, Palo Alto, CA 94303
    Br J Pharmacol 114:49-56. 1995
    ..4 +/- 0.9%) by the muscarinic agonist (+)-cis-dioxolane (-log EC50 = 7.3 +/- 0.1). The rank order of antagonist affinities against the (+)-cis-dioxolane response was (-log KB values in parentheses): atropine ..
  60. pmc 5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases
    G P Reynolds
    Department of Biomedical Science, University of Sheffield
    Br J Pharmacol 114:993-8. 1995
    ..The pharmacology of this site was characterized by use of a series of displacing ligands, and the following rank order of apparent affinities (with mean +/- s.d. -log Ki values in parentheses) was generated: GR113808 (10...
  61. ncbi Uridine receptor: discovery and its involvement in sleep mechanism
    T Kimura
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi, Kanazawa, Japan
    Sleep 24:251-60. 2001
    ..The rank order of the distribution of these specific binding sites was found to be striatum > thalamus > cerebral ..
  62. pmc Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung
    D A Walsh
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:1407-15. 1994
    ..4. [125I]-BH-SP binding was inhibited by tachykinins with rank orders of affinity of SP > NKA > NKB (human microvessels) and SP > NKA = NKB (guinea pig bronchi and ..
  63. pmc Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colon
    C W Shuttleworth
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 109:739-47. 1993
    ..7. Exogenous tachykinins mimicked non-cholinergic excitatory electrical and mechanical responses. The rank order of potency for contraction was neurokinin A>neurokinin B>substance P, suggesting a predominance of the ..
  64. pmc Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area
    B Bowery
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
    Br J Pharmacol 112:873-80. 1994
    ..The rank order of agonist potency was naxagolide > quinpirole > apomorphine > dopamine. 3...
  65. pmc Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 107:27-33. 1992
    ..L 659,877 and R 396 antagonized competitively the response to [PAla8] neurokinin A (4-10) with the following rank order of potency (pA2 values in parentheses): MEN 10,376 (7.41)>L 659,877 (7.15)>R 396 (6.43)...
  66. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
    ..IC25 values (concentration of the agonist required to give a 25% inhibition of the excitatory NANC response) gave a rank order of potency 5-CT > 5-HT> > 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) >alpha-methyl-5-..
  67. pmc Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells
    R Plevin
    Department of Biochemistry, University of Glasgow
    Br J Pharmacol 107:109-15. 1992
    ..analogues stimulated the accumulation of [3H]-IP and [3H]-PtdBuOH with similar EC50 values, generating the same rank order of potency for each response (Arg8-VP = vasotocin = Lys8-VP much greater than oxytocin). 3...
  68. pmc Functional characterization of muscarinic receptors in murine airways
    J Garssen
    Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands
    Br J Pharmacol 109:53-60. 1993
    ..2. The muscarinic receptor antagonists tested inhibited arecoline-induced tracheal contractions with the following rank order of potency: 4-DAMP = atropine > pirenzepine = AFDX-116...
  69. pmc Adenosine receptor-induced second messenger production in adult guinea-pig cerebellum
    F Hernandez
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 110:1085-90. 1993
    ..Adenosine analogues stimulated cyclic AMP generation up to 40 fold with the rank order of potency: 5'-N-ethylcarboxamidoadenosine (0...
  70. pmc Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies
    M Kumari
    Department of Pharmacology, Charing Cross and Westminister Medical School, London
    Br J Pharmacol 121:459-68. 1997
    ..05); the rank order of potency was thus BRL 61063 > rolipram > denbufylline...
  71. pmc Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve: implications for P2 purinoceptor classification
    D J Trezise
    Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge
    Br J Pharmacol 113:463-70. 1994
    ..In Ca2+/Mg2+-free PSS, the rank order of agonist potencies was ATP = 2-methylthioATP = ATP-gamma-S>> alpha,beta-methylene ATP = beta, gamma ..
  72. ncbi Research, academic rank, and compensation of women and men faculty in academic general internal medicine
    P Carr
    Massachusetts General Hospital, Harvard Medical School, Boston 02114
    J Gen Intern Med 7:418-23. 1992
    ..internal medicine, including their professional training, faculty responsibilities, research performance, academic rank, and compensation, to determine whether systematic differences exist by gender...
  73. pmc Identification of renal natriuretic peptide receptor subpopulations by use of the non-peptide antagonist, HS-142-1
    R A Rutherford
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:931-9. 1994
    ..3. In the rat, [125I]-rANP1-28 binding was inhibited by unlabelled peptide sequences with a rank order of potency (rANP1-28 > pCNP1-22 > C-ANP4-23)...
  74. ncbi Fellowship training in academic general internal medicine: a curriculum survey
    J D Orlander
    Department of Medicine, Cambridge Hospital, Harvard Medical School, Cambridge, Massachusetts
    J Gen Intern Med 6:460-5. 1991
    ..Respondents then prioritized elements by rank-ordering them on perceived importance...
  75. pmc Vascular actions of purines in the foetal circulation of the human placenta
    M A Read
    Department of Obstetrics and Gynaecology, John Hunter Hospital, NSW, Australia
    Br J Pharmacol 110:454-60. 1993
    ..6. The rank order of vasodilator potencies of a selection of adenosine receptor agonists was, 2-chloroadenosine>>5-(N-..
  76. ncbi Incidence and survival of brain tumors: a population-based study
    M Sant
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Servizio di Epidemiologia, Milano, Italia
    Tumori 74:243-52. 1988
    ..The probability of survival at 5 years after diagnosis was computed by the method of Kaplan and Meier, and the log rank procedure was used to test statistical differences among survivors...
  77. doi IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells
    Satoshi Kitami
    Department of Oral Health Sciences, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, Japan
    Biochimie 92:398-404. 2010
    ..osteoclastic bone resorption via osteoblasts by inducing the expression of "receptor activator of NF-kappaB (RANK) ligand" (RANKL)...
  78. pmc Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells
    T Kusama
    Molecular Neurobiology, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland 21224
    Br J Pharmacol 109:200-6. 1993
    ..rho 1 receptor were trans-4-aminocrotonic acid (TACA) > GABA > muscimol; at the alpha 5 beta 1 receptor the rank order was muscimol > GABA > 4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-ol (THIP)...
  79. pmc Heterogeneity of muscarinic receptors in lamb isolated coronary resistance arteries
    U Simonsen
    , Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 109:998-1007. 1993
    ..2. The rank order of potency for muscarinic agonist-induced increases in tension in endothelium-intact preparations was ..
  80. pmc Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum
    U Windscheif
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 115:1509-17. 1995
    ..2. The resulting rank order of potency for the adenine nucleotides in guinea-pig taenia coli was: 2-methylthio ATP >> ATP > ..
  81. ncbi The impact of spinal problems on the health status of patients: have we underestimated the effect?
    J C Fanuele
    Department of Surgery, Section of Orthopaedics, and Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA
    Spine (Phila Pa 1976) 25:1509-14. 2000
    ..A prospective study of 17,774 patients who consulted spine centers in which the impact of spinal disorders and comorbidities on physical functional status were evaluated...
  82. pmc The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro
    E H Wong
    Institute of Pharmacology, Palo Alto, California 94303, USA
    Br J Pharmacol 114:851-9. 1995
    ..1, respectively, with Hill coefficients not significantly different from unity. Thus, at these 5-HT3 receptors, the rank order of apparent affinities was (S,S) > (R,S) > (S,R) = (R,R). 3...
  83. pmc Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain
    F P Jansen
    Leiden Amsterdam Center for Drug Research, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, The Netherlands
    Br J Pharmacol 113:355-62. 1994
    ..7. Histamine competition binding curves were shifted to the right by different nucleotides (100 microM) with a rank order of potency GTP gamma S > Gpp(NH)p, GTP...
  84. pmc Effects of muscarinic M2 and M3 receptor stimulation and antagonism on responses to isoprenaline of guinea-pig trachea in vitro
    N Watson
    Syntex Discovery Research, Institute of Pharmacology R2 101, Palo Alto, CA 94303
    Br J Pharmacol 112:179-87. 1994
    ..5 +/- 0.9 nM). The rank order of antagonist apparent affinities (with pA2 values in parentheses) was atropine (9.4 +/- 0...
  85. pmc Adenosine A1-receptor stimulated increases in intracellular calcium in the smooth muscle cell line, DDT1MF-2
    J M Dickenson
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
    Br J Pharmacol 108:85-92. 1993
    ..The rank order of agonist potencies was N6-cyclopentyladenosine > 5'-N-ethylcarboxamidoadenosine > 2-chloroadenosine &..
  86. pmc Age of donor alters the effect of cyclic hydrostatic pressure on production by human macrophages and osteoblasts of sRANKL, OPG and RANK
    C E Evans
    Laboratory and Regenerative Medicine, Stopford Building, The Medical School, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    BMC Musculoskelet Disord 7:21. 2006
    ..receptor activator of NF-kappa beta ligand /receptor activator of NF-kappa beta (OPG/ RANKL/ RANK) triumvirate has been implicated in control of bone resorption under various circumstances...
  87. pmc The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels
    I K Wright
    Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
    Br J Pharmacol 114:678-88. 1995
    ..03-10 microM) elicited concentration-dependent contractions in the TA and MEV, with a rank order of potency of UK14304 > NA > PE...
  88. ncbi Norwegian adults' perceived need for coping skills to adjust to dental and non-dental life events
    O Haugejorden
    Department of Community Dentistry, University of Bergen, Norway
    Community Dent Oral Epidemiol 21:57-61. 1993
    ..Mean values were calculated and used to rank the life events. "Losing one or more teeth" was ranked 30 (mean = 11.8; SD = 5...
  89. ncbi Increasing referral of at-risk travelers to travel health clinics: evaluation of a health promotion intervention targeted to travel agents
    L A MacDougall
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    J Travel Med 8:232-42. 2001
    ..The Wilcoxon signed rank test was used to compare the mean difference in overall scores to evaluate the overall impact of the intervention ..
  90. pmc Identification of both NK1 and NK2 receptors in guinea-pig airways
    K T McKee
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire, Dorval, , Canada
    Br J Pharmacol 110:693-700. 1993
    ..The rank order of affinity for competing tachykinins was as predicted for an NK1 receptor: substance P = [Sar9Met(O2)11]..
  91. pmc Differential effects of phosphoramidon on contractile responses to angiotensin II in rat blood vessels
    L Chen
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, 0W0, Canada
    Br J Pharmacol 114:1599-604. 1995
    ..01) and mesenteric artery (P < 0.05) but not in aorta. The rank order of sensitivity to the inhibition by phosphoramidon was tail artery > mesenteric artery > aorta...
  92. ncbi Quality-adjusted meta-analysis of the hypertension/coronary dilemma
    I Holme
    Life Insurance Companies' Institute for Medical Statistics, Oslo, Norway
    Am J Hypertens 7:703-12. 1994
    ..This stayed unchanged until HDFP at rank 11 was included raising this estimate to 16%...
  93. pmc Identification of a novel calcium antagonist binding site in rat brain by SR 33557
    B A Kenny
    Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh
    Br J Pharmacol 108:93-9. 1993
    ..The affinity of Cd2+ was 0.026 +/- 0.015 mM and the rank order of affinity was Cd2+ >Ca2+ >Mn2+ >Mg2+ >Na+.7...
  94. pmc Investigation of the 5-hydroxytryptamine receptor mediating the 'maintained' short-circuit current response in guinea-pig ileal mucosa
    C M Scott
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Herts
    Br J Pharmacol 106:877-82. 1992
    ..3. In the presence of IBMX, 5-HT stimulated reproducible increases in SCC with an EC50 value of 0.9 microM. The rank order of potency of indole agonists in these tests was 5-HT greater than or equal to 5-methoxytryptamine greater ..
  95. ncbi Advances in the treatment of osteoporosis
    N H Bell
    Strom Thurmond Research Building, 114 Doughty Street, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Drug Targets Immune Endocr Metabol Disord 1:93-102. 2001
    ..Interaction between the receptor for activation of nuclear factor kappa B (RANK) on the surface of preosteoclasts and osteoclasts and RANK ligand on the surface of osteoblasts is required to ..
  96. pmc Differential localization of endothelin ETA and ETB binding sites in human placenta
    R A Rutherford
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 109:544-52. 1993
    ..3. [125I]-ET-1 binding sites exhibited a rank order of inhibition by unlabelled peptide sequences (ET-1 > ET-3 > [Ala3,11,18Nle7]-ET-1 > BQ123 > or = ..
  97. pmc Evidence for a nucleotide receptor on adrenal medullary endothelial cells linked to phospholipase C and phospholipase D
    J R Purkiss
    Department of Pharmacology and Therapeutics, University of Leicester
    Br J Pharmacol 108:1031-7. 1993
    ..The total [3H]-inositol phosphate responses were with a rank order of UTP > ATP- = adenosine 5'-O-(3-thio-triphosphate) (ATP gamma S) >> 2MeSATP...
  98. ncbi [Improved prognosis of first episode HIV associated Pneumocystis carinii pneumonia without preventive treatment: etiology and sequelae]
    S Ewig

    Pneumologie 50:455-61. 1996
    ..The prognosis of late episodes was significantly improved (7 versus 32% lethal outcomes, log rank p < 0.01)...
  99. ncbi Flow cytometric and immunohistochemical correlations in high incidence human solid tumors
    D T Danesi
    Sezione di Tossicologia e Scienze Biomediche, ENEA CR Casaccia, Rome, Italy
    Tumori 83:689-97. 1997
    ..of the results obtained by the different techniques have been attempted by the non-parametric Spearman's rank correlation approach. Significant associations (P < 0...
  100. ncbi Nature of [3H]rilmenidine binding to membranes of rat cerebral cortex
    P R King
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Australia
    Am J Hypertens 5:64S-68S. 1992
    ..up to 50% of specific, 2 nmol/L [3H]rilmenidine binding and was displaceable by the catecholamines in the rank order epinephrine----norepinephrine----dopamine----isoproterenol...
  101. ncbi Frictional heating of bearing materials tested in a hip joint wear simulator
    Z Lu
    J Vernon Luck Orthopaedic Research Center, Los Angeles Orthopaedic Hospital, USA
    Proc Inst Mech Eng H 211:101-8. 1997
    ..The rank order of the surface temperatures corresponded to the relative amounts of protein that were precipitated in the ..

Research Grants70

  1. ATF4 and Osteoclastogenesis
    Guozhi Xiao; Fiscal Year: 2013
    ..Our data indicate that ATF4 mediates M-CSF-induced expression of RANK, a critical molecular event required for early differentiation of OCLs...
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..RANKL is a member of the TNF family expressed on the surface of osteoblasts which signals through the receptor RANK on the surface of osteoclast precursors to stimulate osteoclastogenesis...
  4. Ginger Extracts in the Prevention of Metabolic Bone Disease
    LAURA ELIZABETH WRIGHT; Fiscal Year: 2011
    ..bone disorders in which bone destruction is mediated through activation of the receptor activator of NF-kB (RANK) pathway, the final common pathway for bone resorption...
  5. Lionel B Ivashkiv; Fiscal Year: 2016
    ..been implicated in promoting osteoclast differentiation by providing costimulatory signals required for effective RANK responses...
  6. Hyeong Reh Choi Kim; Fiscal Year: 2016
    ..unveiled exciting new roles of PDGF D in the regulation of osteoclast differentiation independent of the RANKL/RANK signaling axis as well as osteoblast differentiation involving modulation of homeoprotein expression...
  7. Bin Wang; Fiscal Year: 2015
    ..The engagement of RANKL binding to RANK leads to induction of gene expression involved in osteoclastogenesis...
  8. Rajaram Gopalakrishnan; Fiscal Year: 2014
    ..precursors are already primed to RANKL and/or M-CSF, (3B) determining whether Twsg1 disruption leads to altered RANK-mediated signaling pathways;and (3C) evaluating if NFAT-c1 is a target of Twsg1-deficiency ...
  9. Regulation of Myeloid Development and Function by II-4
    Achsah D Keegan; Fiscal Year: 2010
    ..in the developing progenitors altering the differentiation fate of a multipotential precursor, (2) influencing RANK-initiated responses in committed progenitors, and (3) suppressing the bone resorbing activity of mature osteoclasts...
  10. Statistical methods for assessing copy number variation in SNP arrays
    Robert B Scharpf; Fiscal Year: 2012
    ..First, 1 successfully identified a tenure-track faculty position at the rank of Assistant Professor. Faculty in the Department of Oncology are supportive of the development of these methods...
  11. Negative Regulation of Osteoclastogenesis by Inflammatory Signals
    Kyung Hyun Park-Min; Fiscal Year: 2013
    ..We have found that TLR stimulation strongly suppresses osteoclastogenesis by inhibiting RANK, a key receptor required for osteoclastogenesis...
  12. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven L Teitelbaum; Fiscal Year: 2012
    ..for all pathological bone resorption, namely RANKL, whose crystal structure, in complex with its receptor, RANK, we resolved in the current funding period...
  13. Joseph A Lorenzo; Fiscal Year: 2016
    ..osteoclast differentiation;(ii) examine if Rux1-mediated inhibition of osteoclastogenesis depends on inhibition of RANK-signaling;(iii) Runx1 alters osteoclast precursor lineage commitment and differentiation by regulating critical ..
  14. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..TRAF6 also mediates signaling from receptor activator of NF-?B (RANK) and CD40, TNFR family members involved in the differentiation and effector functions of osteoclasts and B ..
  15. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..The central hypothesis guiding the proposed experiments is that RANKL acting through its receptor RANK on epithelial cells is a critical signaling pathway required for normal M cell differentiation and function...
  16. ROBERT WADE SIGGINS; Fiscal Year: 2015
    ..b>RANK/c-FOS and Wnt/Frizzled (FZD)/[unreadable]-catenin pathways are two major signaling systems involved in ODC ..
  17. Alcohol-induced Osteoimmunopathies: A Unifying Explanatory Mechanism
    ROBERT WADE SIGGINS; Fiscal Year: 2012
    ..b>RANK/c-FOS and Wnt/Frizzled (FZD)/2-catenin pathways are two major signaling systems involved in ODC differentiation to ..
  18. AVI MA'AYAN; Fiscal Year: 2015
    ..Here we propose an alternative rational approach, called Expression2Kinases, to identify and rank transcription factors, chromatin modifiers, protein complexes, and protein kinases that are likely responsible for ..
  19. Yousef Abu-Amer; Fiscal Year: 2016
    ..Differentiation of osteoclasts is governed by RANK ligand which activates several signal transduction pathways, including MAP kinases and NF-?B pathways...
  20. The role of CTGF in bone cell development and function
    Steven N Popoff; Fiscal Year: 2012
    ..g. RANK-L) by stromal cells/osteoblasts in the bone microenvironment...
  21. IKKa-Dependent Negative Feedback Control of Non-Canonical NF-kB Activation
    Genhong Cheng; Fiscal Year: 2012
    ..non-canonical NF-:B signaling is activated over hours by a select group of receptors such as BAFF, LT2R, CD40 and RANK on a limited number of cell types such as B-cells, fibroblasts, and macrophages...
  22. MELISSA LE HOA VO; Fiscal Year: 2014
    ..It allows neural signatures, elicited in response to a sequence of images, to be used to rank those images in order of their implicit 'interest'to the viewer...
  23. Nina A Mayr; Fiscal Year: 2015
    ..at-risk tumor voxels, 2) Validate the predictive power of MRI and PET imaging metrics with treatment outcome and rank the comparative effectiveness at different time points, and 3) Derive novel multivariate predictive algorithms from ..
  24. Carl B Shanholtz; Fiscal Year: 2016
    ..from 2x4 repeated measures analysis or mixed linear modeling and Cochran's Q for 2x2 repeated measures on rank data...
  25. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..seems to cause activation of a partial osteoclast differentiation program, similar to that induced by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase...
  26. DAP12 and ITAM-signals in Osteoclastogenesis
    Mary C Nakamura; Fiscal Year: 2013
    ..Osteoclast development requires receptor stimulation through RANK (receptor for activation of NFkappaB), and c-fms (receptor for macrophage colony stimulating factor, M-CSF)...
  27. Xu Feng; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The receptor activator of NF-?B (RANK) ligand (RANKL), a member of the tumor necrosis factor (TNF) superfamily, plays an essential role in osteoclast (OC) formation, function and survival by binding ..
  28. KATHERINE NELSON WEILBAECHER; Fiscal Year: 2015
    ..Osteoprotegerin (OPG) receptor activator of nuclear factor-kB (RANK) and RANK ligand (RANKL) pathway plays a central role in bone destruction through osteoclast differentiation and ..
  29. Brendan F Boyce; Fiscal Year: 2016
    ..Expression of these is essential for osteoclast formation. RANKL/RANK signals through a canonical NF-?B1/p65 and an alternative NF-?B2/RelB pathway...
  30. Michael E Rosenfeld; Fiscal Year: 2016
    ..b>RANK-RANKL plays an essential role in bone homeostasis by stimulating the differentiation of osteoclasts...
  31. GENETIC BASES FOR DISEASES OF THE RANK SIGNALING PATHWAY
    STEVEN R MUMM; Fiscal Year: 2013
    ..DNA and RNA samples will be screened for mutations in TNFRSF11B, encoding OPG, TNFRSF11A, encoding RANK, and TNFSF11, encoding RANKL, using PCR and capillary DNA sequencing, and RT-PCR...
  32. Molecular mechanisms of the innate regulation of osteoclastogenesis.
    Ping Zhang; Fiscal Year: 2013
    ..The receptor activator of NF-?B ligand (RANKL) and its receptor RANK are the key regulators for bone remodeling and for the activation of OC...
  33. Regulatory T Cells and Tumor Bone Marrow Metastasis
    Weiping Zou; Fiscal Year: 2010
    ..Receptor activator of NF-kB (RANK) and its ligand RANKL signals are implicated in Treg expansion in diabetes and ultraviolet-induced immune ..
  34. Osteoclastogenesis and RANK signaling to NF-kB via TRAF6
    JASON BOCH; Fiscal Year: 2005
    ..Ligand (RANKL) which mediates its effects via a specific cell surface receptor, Receptor and Activator of NF-kB (RANK). This receptor is a member of the TNF receptor family, and is expressed on osteoclasts and osteoclast precursors...
  35. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  36. Targeting FGFR to prevent the outgrowth of metastatic breast cancer
    MICHAEL KEITH WENDT; Fiscal Year: 2013
    ..I currently hold the position of Senior Research Associate, the highest postdoctoral training rank at Case Western Reserve University...
  37. MYCN Function in Neuroblastoma
    Naohiko Ikegaki; Fiscal Year: 2012
    ..significance of MYCN expression in subsets of high-risk MYCN-non-amplified NB by Kaplan-Meier analysis and log rank test, (Aim 2) identify MYCN target genes that provide NB with a favorable phenotype (favorable NB gene candidates) ..
  38. Georgios I Papachristou; Fiscal Year: 2014
    ..We now seek to use the 5-biomarker panel data to fit diverse statistical models and rank their ability to predict risk of persistent organ failure through cross- validation...
  39. SCOTT MICHAEL BARTELL; Fiscal Year: 2014
    ..studies of the health effects of these pollutants is characterizing those patterns accurately enough to rank study participants by the amount of pollutant exposure at any particular point in time or cumulatively over a given ..
  40. Nucleosides and TREM2 Mediate Inflammation-Induced Bone Loss
    George Pan; Fiscal Year: 2010
    ..TREM2 has been demonstrated to be a costimulatory receptor enhancing RANK-mediated osteoclastogenesis. However, the specific ligand for TREM2 has not yet been identified...
  41. RANK-Associated Inhibitor (RAIN) in Osteoclast Formation
    Bryant Darnay; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Receptor activator of NF-kappaB (RANK) and its ligand (RANKL, also known as TRANCE/ODF/OPGL) are essential mediators of osteoclastogenesis and have been implicated in various diseases, which include ..
  42. TRAF6 E3 LIGASE FUNCTION IN OSTEOCLASTOGENESIS
    Bryant G Darnay; Fiscal Year: 2010
    b>RANK plays a central role in the maintenance of the bone homeostasis by regulating the differentiation and activation of osteoclasts...
  43. Plasma Osteoprotegerin and Adverse Outcomes in CHD Patients
    Iftikhar J Kullo; Fiscal Year: 2013
    ..Circulating levels of OPG are easily measured, in contrast to RANK and RANKL that are expressed locally in the cardiac and vascular tissue...
  44. RODNEY JON SCHLOSSER; Fiscal Year: 2014
    ..Iraqi Freedom (OIF) Veterans has been a consistent finding that affects military personnel regardless of age, rank, gender or active duty/National Guard status...
  45. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Clones will be rank ordered by their affinity and specificity for MBG. Finally, we will evaluate function in an NKA assay...
  46. Screening Complete TB Proteome for Protective Antigens
    Alan Greener; Fiscal Year: 2010
    ..proteome by 1) applying bioinformatic analyses to predict the immunogenicity of each open reading frame (ORF) and rank the genome accordingly, then 2) synthesizing and purifying the proteins to create protein arrays for subsequent ..
  47. Arnold Louie; Fiscal Year: 2014
    ..It is the intent of this proposal to examine up to five of these molecules over the span of the proposal, rank order them and, for at least two of the molecules, to progress them into New Drug Applications...
  48. April N Herrity; Fiscal Year: 2014
    ..Furthermore, deficits in urological functin rank high as one of the most important factors affecting quality of life for SCI patients 6...
  49. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..Aim #1: Rank order the potency of R-100 and its analogues in a rodent model of LIRI R- 100 (both enantiomers) will be compared ..
  50. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Bioassays of plasma from severe and non-severe SCD patients and control subjects will be used to identify and rank potential partners that impair vasodilation and shift the balance of nitric oxide (-NO) and superoxide anion (O2...
  51. Patrick F Sullivan; Fiscal Year: 2015
    ..MDD is a first-rank public health problem due to the associated morbidity, mortality, and personal/societal costs...
  52. Evaluation of Safety Training, Supervision, and Injury Among Working Teenagers.
    KRISTINA MARIE ZIEROLD; Fiscal Year: 2010
    ..National Pediatric Trauma Registry and National Center for Health Statistics report that injuries due to occupation rank fourth in injuries among youth aged 10 to 19 years, led only by motor vehicle wrecks, violence, and recreational ..
  53. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    ..The Specific Aims are: 1. Synthesize new peptide/DNA mimetope small molecules and determine their rank order of efficacy in in vitro assays. 2...
  54. Dietary Patterns, Diet Quality + Cancer Risk
    Frank B Hu; Fiscal Year: 2012
    ..g., 4-12 years). 3). Using a novel statistical approach, Reduced Rank Regression (RRR), we will develop diet patterns that represent the effect of diet on increased insulin resistance (..
  55. Rebecca M Brotman; Fiscal Year: 2014
    ..opportunity to investigate four specific aims: 1) Characterize the changes in structure (species composition and rank abundance) of vaginal microbial communities over time;2) Develop a molecular model for the diagnosis of BV;3) Apply ..
  56. The XXII nd North American Testis Workshop
    WILLIAM WALLACE WRIGHT; Fiscal Year: 2013
    ..talks from abstracts that are submitted by young investigators (trainees and Assistant Professors who have been in rank for no more than 2 years...
  57. Marcia B Goldberg; Fiscal Year: 2016
    ..Of these individuals, 175 now hold positions in academia or work in government service. Sixty hold the rank of assistant professor or higher at 52 colleges, universities and medical schools around the world...
  58. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
    ..The underlying causes of fatty liver (FL) are numerous, but alcohol intake and obesity rank as the most common...
  59. Epigenetics and Nutrition: DNA Methylation, Dietary Intake and CVD
    Annette L Fitzpatrick; Fiscal Year: 2012
    ..Cox proportional hazards regression for incidence of CVD and mortality, and multiple linear regression and reduced rank regression for continuous measures of dietary intake...
  60. Karen J Parker; Fiscal Year: 2015
    ..Data on dominance rank, maternal protectiveness, and social support (social network size;grooming received;aid during agonistic ..
  61. Jeffrey D Esko; Fiscal Year: 2016
    ..The resultant rank ordering of potency of confirmed hit sets and chemotypes merged with additional secondary and tertiary assay ..
  62. Interactions between Urological and Locomotor Systems during Treadmill Training i
    Patricia J Ward; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Both quadriplegics and paraplegics rank bladder function as one of the most important factors affecting their quality of life, and 96...
  63. Min Guo; Fiscal Year: 2015
    ..To rank order compound activity, EC50's will be determined and the chemical tractability of the chose 'hits'..
  64. Variation in the Safety of Back Pain-Related Surgery
    Sohail K Mirza; Fiscal Year: 2010
    ..We will rank de-identified individual hospitals and surgeons by reoperation rate and identify hospital/surgeon features ..
  65. Regulation of ITK in Lung Allergy
    Constantine D Tsoukas; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung allergies, in particular Bronchial Asthma, rank among the most common chronic conditions in the United States, affecting approximately 15 million Americans and causing serious illness and several ..
  66. Cell-Based Assays for Identifying Anti-RANK Signaling Agents
    Xu Feng; Fiscal Year: 2007
    ..RANKL regulates OC formation and function by activating its receptor RANK (the receptor activator of NF-?B) on OC precursors and mature OCs...
  67. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ..Anorexia nervosa (AN) is a terrifying and perplexing disorder. Eating disorders, in general, rank among the top ten causes for disability among women, while AN has the highest mortality rate of any psychiatric ..
  68. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
    ..In studies involving repeated 14 day injection procedures, the rank order of the ratios of the ED50s for suppression of tacrine-induced jaw movements and lever injection procedures, ..
  69. EQUITY OF INPATIENT SURGERY UTILIZATION IN CALIFORNIA
    Mita Giacomini; Fiscal Year: 1992
    ..To answer the second research question, Spearman's rank correlation coefficients will be used to measure correlations between the procedure-specific degree of inequity and ..