TNFR2

Summary

Gene Symbol: TNFR2
Description: TNF receptor superfamily member 1B
Alias: CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, tumor necrosis factor receptor superfamily member 1B, TNF-R2, TNF-RII, p75 TNF receptor, p80 TNF-alpha receptor, soluble TNFR1B variant 1, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, tumor necrosis factor receptor 2, tumor necrosis factor receptor type II
Species: human

Top Publications

  1. ncbi Increased hypothalamic expression of the p75 tumor necrosis factor receptor in New Zealand obese mice
    N M Rizk
    Physiology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
    Horm Metab Res 33:520-4. 2001
  2. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
  3. ncbi Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
    S A Marsters
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080 4918, USA
    J Biol Chem 272:14029-32. 1997
  4. ncbi HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells
    Jose A Beltran
    Department of Biology, Seton Hall University, McNulty Hall, Room 215, South Orange, NJ 07079, USA
    Int Immunopharmacol 6:1459-67. 2006
  5. pmc Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
    Y Wang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Biol 20:4505-12. 2000
  6. ncbi The death domain of tumor necrosis factor receptor 1 is necessary but not sufficient for Golgi retention of the receptor and mediates receptor desensitization
    M L Gaeta
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Lab Invest 80:1185-94. 2000
  7. ncbi TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
    Masataka Nishimura
    Department of the Clinical Neuroscience, Tokushima University Hospital, Japan
    Hum Immunol 64:302-9. 2003
  8. pmc Elevated levels of soluble TNF receptors 1 and 2 correlate with Plasmodium falciparum parasitemia in pregnant women: potential markers for malaria-associated inflammation
    Audrey Davidson Thévenon
    Department of Biology, Georgetown University, Washington, D C 20057, USA
    J Immunol 185:7115-22. 2010
  9. ncbi TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells
    Leng Wen
    Department of Antibody Development, Human Genome Sciences, Inc, Rockville, Maryland 20833, USA
    J Biol Chem 278:39251-8. 2003
  10. ncbi Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    R Sacca
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 160:485-91. 1998

Research Grants

  1. TNF receptor-2 signaling in arteriogenesis/angiogenesis
    Wang Min; Fiscal Year: 2010
  2. Regulation of neurotransmitter properties by target-derived neurotrophic factors
    Susan J Birren; Fiscal Year: 2010
  3. Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells
    Jeffrey L Spees; Fiscal Year: 2012
  4. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
  5. Giovanni Piedimonte; Fiscal Year: 2016
  6. Frank B Hu; Fiscal Year: 2016
  7. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
  8. DOUGLAS LOWELL MANN; Fiscal Year: 2016
  9. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
  10. Paul L Fox; Fiscal Year: 2016

Detail Information

Publications236 found, 100 shown here

  1. ncbi Increased hypothalamic expression of the p75 tumor necrosis factor receptor in New Zealand obese mice
    N M Rizk
    Physiology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
    Horm Metab Res 33:520-4. 2001
    ..Using RT-PCR, we observed increased expression (2.4-fold) of TNF receptor 2 (p75) in the hypothalamus of obese mice...
  2. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..We investigated the distinct roles of TNFR1 and TNFR2 in spinal cord synaptic transmission and inflammatory pain...
  3. ncbi Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
    S A Marsters
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080 4918, USA
    J Biol Chem 272:14029-32. 1997
    ..These results suggest that HVEM is linked via TRAFs to signal transduction pathways that activate the immune response...
  4. ncbi HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells
    Jose A Beltran
    Department of Biology, Seton Hall University, McNulty Hall, Room 215, South Orange, NJ 07079, USA
    Int Immunopharmacol 6:1459-67. 2006
    ..Our data suggest that one of the mechanisms by which HIV-1 gp120 up-regulates the MOR in TPA-differentiated HL-60 cells is through autocrine/paracrine actions of TNF-alpha via the TNFR-II receptor...
  5. pmc Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
    Y Wang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Biol 20:4505-12. 2000
    ..Thus, Stat1 acts as a TNFR1-signaling molecule to suppress NF-kappaB activation...
  6. ncbi The death domain of tumor necrosis factor receptor 1 is necessary but not sufficient for Golgi retention of the receptor and mediates receptor desensitization
    M L Gaeta
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Lab Invest 80:1185-94. 2000
    TNF signals are mediated through two different receptors, TNFR1 and TNFR2. In endothelial cells, TNFR1 is predominantly localized in the Golgi apparatus and TNFR2 on the plasma membrane...
  7. ncbi TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
    Masataka Nishimura
    Department of the Clinical Neuroscience, Tokushima University Hospital, Japan
    Hum Immunol 64:302-9. 2003
    ..We also analyzed TNF receptors type 1 (TNFR1) and type 2 (TNFR2) gene polymorphisms, located on chromosome 12p13 and 1p36, respectively...
  8. pmc Elevated levels of soluble TNF receptors 1 and 2 correlate with Plasmodium falciparum parasitemia in pregnant women: potential markers for malaria-associated inflammation
    Audrey Davidson Thévenon
    Department of Biology, Georgetown University, Washington, D C 20057, USA
    J Immunol 185:7115-22. 2010
    ..Two counterregulatory molecules, TNF-αR (TNFR) 1 and TNFR2, modulate the pathological effects of TNF-α...
  9. ncbi TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells
    Leng Wen
    Department of Antibody Development, Human Genome Sciences, Inc, Rockville, Maryland 20833, USA
    J Biol Chem 278:39251-8. 2003
    ..Furthermore, inhibition of c-IAP2 production by RNA interference significantly sensitized TF-1 cells to TL1A-induced apoptosis. Our study identifies a molecular mechanism by which TL1A and DR3 regulate cell fate in TF-1 cells...
  10. ncbi Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    R Sacca
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 160:485-91. 1998
    ..Secreted LT alpha3 can bind to two cell surface receptors, TNFR1 and TNFR2, while the membrane-bound heterotrimer LT alpha1beta2 has been shown to interact with a distinct receptor, LT ..
  11. ncbi Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
    ..adapter protein, which, upon TNF stimulation, is directly recruited to the intracellular region of TNF receptor 2 (TNFR2) or indirectly, via TRADD, to the intracellular region of TNF receptor 1 (TNFR1)...
  12. ncbi Transendothelial migration of myeloma cells is increased by tumor necrosis factor (TNF)-alpha via TNF receptor 2 and autocrine up-regulation of MCP-1
    Karin Johrer
    Tyrolean Cancer Research Institute at the University of Innsbruck, Innsbruck, Austria
    Clin Cancer Res 10:1901-10. 2004
    ..In summary, our data clearly support additional investigations using anti-MCP-1 antibodies in myeloma progression...
  13. ncbi Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab
    M Pierik
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 20:303-10. 2004
    ..Tumour necrosis factor-alpha exerts its effect by binding TNFR1 and TNFR2, which genes map to inflammatory bowel disorders susceptibility loci.
  14. ncbi Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences
    Z Dembic
    Central Research Unit, F Hoffmann LaRoche Ltd, Basel, Switzerland
    Cytokine 2:231-7. 1990
    ..In marked contrast to the extracellular regions, the intracellular domains of the two TNF receptors are entirely unrelated, suggesting different modes of signaling and function...
  15. ncbi Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors
    H Engelmann
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 265:1531-6. 1990
    ..The findings presented in this study are consistent with the notion that the urinary TNF-binding proteins constitute soluble forms of the two molecular species of the cell surface TNF receptors...
  16. ncbi TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
    ..A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling...
  17. ncbi The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Cell 80:389-99. 1995
    ..The interaction of LMP1 with these TNFR family-associated proteins is further evidence for their role in signaling and links LMP1-mediated transformation to signal transduction from the TNFR family...
  18. ncbi A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
    M Rothe
    Department of Molecular Biology, Genentech, Incorporated, South San Francisco, California 94080
    Cell 78:681-92. 1994
    ..TRAF1 interacts with TNF-R2 indirectly through heterodimer formation with TRAF2...
  19. ncbi The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
    M Rothe
    Department of Molecular Biology Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 83:1243-52. 1995
    The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously...
  20. ncbi Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization
    S M Santee
    Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:21151-9. 1996
    Tumor necrosis factor receptor p75 (TNF-R p75) is a 75-kDa type I transmembrane protein expressed predominantly on cells of hematopoietic lineage...
  21. ncbi Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease
    R A Allen
    Blackpool Victoria Hospital, Whinney Heys Road, Blackpool, UK
    Eur J Clin Invest 31:843-51. 2001
    ..We have therefore investigated whether polymorphisms in the TNF-alpha (- 238 and - 308), TNF receptor 1 (position - 609 and + 10, intron 6) and TNF receptor 2 (position + 422, codon 198) genes show an association with CAD...
  22. ncbi Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis
    C Morita
    Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Arthritis Rheum 44:2819-27. 2001
    ..To investigate whether a polymorphism(s) or mutation(s) in the tumor necrosis factor receptor II (TNFRII) gene is involved in the pathogenesis of systemic lupus erythematosus (SLE)...
  23. ncbi Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2
    Begoña Laínez
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Int Immunol 16:169-77. 2004
    ..The biological effects of TNF-alpha are mediated via the cell-surface TNF receptors TNFR1 and TNFR2. Soluble forms of these two receptors, which contain the extracellular ectodomains, are proteolytically cleaved ..
  24. ncbi Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes
    Kevin A Waschke
    Department of Medicine, Division of Gastroenterology, McGill University Inflammatory Bowel Disease Program, Montreal, Canada
    Am J Gastroenterol 100:1126-33. 2005
    ..Our purpose was to determine whether single nucleotide polymorphisms (SNPs) in the TNF receptors confer susceptibility to Crohn's disease and whether they are associated with clinical phenotype...
  25. ncbi A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma
    Souhir Mestiri
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Université du Centre, Monastir, Tunisia
    Cytokine 30:182-7. 2005
    ..We investigated the susceptibility and prognostic implications of the genetic variation in the TNFRII in breast carcinoma...
  26. ncbi A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes
    Iris Shai
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Diabetes Care 28:1376-82. 2005
    ..Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by adipose tissue and other cells, might play a role in insulin resistance...
  27. pmc A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis
    Takahiko Horiuchi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Ann Rheum Dis 66:320-4. 2007
    ....
  28. doi Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation
    A Wicovsky
    Department of Internal Medicine II, Division of Molecular Internal Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Oncogene 28:1769-81. 2009
    It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NFkappaB and JNK...
  29. pmc Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India
    Rubina Tabassum
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi, 110 007, India
    Genomic Med 2:93-100. 2008
    ..type 2 diabetes and various lines of evidences suggest an important contribution of type 2 receptor for TNFalpha (TNFR2), a mediator of inflammatory responses...
  30. doi Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Rheumatol 36:2195-203. 2009
    ..Along with environmental factors such as smoking, both polymorphisms may modulate an individual's susceptibility to SLE. We investigated these relationships in a case-control study to evaluate risk factors for SLE among Japanese women...
  31. pmc Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2)
    Hilka Rauert
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 285:7394-404. 2010
    Tumor necrosis factor (TNF) elicits its biological activities by stimulation of two receptors, TNFR1 and TNFR2, both belonging to the TNF receptor superfamily...
  32. doi Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response
    Catherine Potter
    Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University
    Pharmacogenet Genomics 20:338-41. 2010
    ..We hypothesized that variants spanning the type 2 TNF receptor (TNFR2) and the TNF cleavage enzyme (TACE) genes contribute towards the observed variation in patient response (defined ..
  33. pmc Endothelial-specific transgenesis of TNFR2 promotes adaptive arteriogenesis and angiogenesis
    Yan Luo
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Arterioscler Thromb Vasc Biol 30:1307-14. 2010
    We have previously shown that the tumor necrosis factor receptor 2 (TNFR2) protein is highly upregulated in vascular endothelium in response to ischemia, and a global deletion of TNFR2 in mice blunts ischemia-induced arteriogenesis and ..
  34. pmc TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
    Akiko Kuwahara
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Exp Clin Cancer Res 29:100. 2010
    ....
  35. doi Polymorphism of 3'UTR region of TNFR2 coding gene and its role in clinical tuberculosis in Han Chinese pediatric population
    Igor Mokrousov
    Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics Capital Medical University, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    Infect Genet Evol 11:1312-8. 2011
    ..b>TNFR2 encoded by the TNFRSF1B gene is one of the important TNF-α receptors; its polymorphisms were previously suggested ..
  36. pmc TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy
    Xiaoxiang Guan
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    BMC Cancer 11:447. 2011
    ..However, few reported studies have investigated the association between potentially functional SNPs in both TNF-α and TNFRSF1B and prognosis of NSCLC patients treated with chemoradiotherapy...
  37. doi Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma
    Christina Heemann
    Department of Hematology and Oncology, Medical Center of the Georg August University Göttingen, Germany
    Clin Cancer Res 18:3637-47. 2012
    ..Therefore, we tested whether gene variations and serum levels of soluble TNF receptor (TNFR)I (sTNFRI), sTNFRII, interleukin (IL)-10, or sIL-4R are predictive for treatment response in T-NHLs...
  38. doi Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease
    C Steenholdt
    Department of Gastroenterology, Herlev Hospital, Denmark
    Aliment Pharmacol Ther 36:650-9. 2012
    ..Single nucleotide polymorphisms (SNPs) in TNF receptor superfamily (TNFRSF) 1A and 1B, and Fas ligand (FASLG) genes, have been associated with responsiveness to infliximab (IFX) in Crohn's disease...
  39. doi Quantitative flow cytometric analysis of expression of tumor necrosis factor receptor types I and II on mononuclear cells
    Julia A Lopatnikova
    Laboratory of Molecular Immunology, Federal State Budgetary Institution Research Institute of Clinical Immunology, Russian Academy of Medical Sciences Siberian Branch, Novosibirsk, Russia
    J Recept Signal Transduct Res 33:49-55. 2013
    ....
  40. ncbi The gene for the type II (p75) tumor necrosis factor receptor (TNF-RII) is localized on band 1p36.2-p36.3
    O Kemper
    Department of Molecular Genetics and Virology, Weitzmann Institute of Science, Rehovot, Israel
    Hum Genet 87:623-4. 1991
    The gene encoding the type II (p75) tumor necrosis factor receptor (TNF-RII) has been localized on human chromosome 1, band 1p36.2 by nonradioactive in situ hybridization...
  41. pmc A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor
    T Kohno
    Synergen, Inc, Boulder, CO 80301
    Proc Natl Acad Sci U S A 87:8331-5. 1990
    ..These three receptor molecules are therefore members of a family of polypeptide hormone receptors...
  42. ncbi Physical mapping and genomic structure of the human TNFR2 gene
    C P Beltinger
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104 4318, USA
    Genomics 35:94-100. 1996
    The tumor necrosis factor receptor 2 (TNFR2) gene localizes to 1p36. 2, a genomic region characteristically deleted in neuroblastomas and other malignancies...
  43. pmc I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
    M Rothe
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:8241-6. 1996
    ..Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state...
  44. ncbi A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    F K Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 288:2351-4. 2000
    ..Thus, TNFRs and related receptors appear to function as preformed complexes rather than as individual receptor subunits that oligomerize after ligand binding...
  45. ncbi Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians
    A Barton
    University of Manchester, UK
    Arthritis Rheum 44:61-5. 2001
    ..The present study was undertaken to investigate association of polymorphisms of TNFRI and TNFRII with RA in subjects in the UK...
  46. ncbi TNFRSF1B in genetic predisposition to clinical neuropathy and effect on HDL cholesterol and glycosylated hemoglobin in type 2 diabetes
    A V Benjafield
    Department of Physiology and Institute for Biomedical Research, The University of Sydney, Australia
    Diabetes Care 24:753-7. 2001
    ..Here we tested the TNFRSF1B marker used in the latter studies in type 2 diabetes patients...
  47. ncbi Tumor necrosis factor receptor 2 gene (TNFRSF1B) in genetic basis of coronary artery disease
    A V Benjafield
    Department of Physiology and Institute for Biomedical Research, The University of Sydney, Australia
    J Mol Med (Berl) 79:109-15. 2001
    ..sTNF-R2 was correlated with age, cholesterol, creatinine, fibrinogen, transforming growth factor beta and homocysteine and was influenced by TNFRSF1B genotype. Thus genetic variation in or near the TNFRSF1B locus may predispose to CAD...
  48. ncbi Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity
    Philippe Dieude
    GenHotel, Evry Genopole, France
    Arthritis Rheum 46:2039-44. 2002
    ..Results of genome scans have suggested that TNFR2 is a candidate rheumatoid arthritis (RA) locus...
  49. ncbi Tumor necrosis factor-alpha receptor II polymorphism in patients from southern Europe with mild-moderate and severe rheumatoid arthritis
    Martina Fabris
    Division of Rheumatology, DPMSC School of Medicine University of Udine, Italy
    J Rheumatol 29:1847-50. 2002
    ....
  50. ncbi Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation
    Gail L Stark
    Department of Haematology, Royal Victoria Infirmary, University of Newcastle, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, United Kingdom
    Transplantation 76:1742-9. 2003
    ....
  51. ncbi The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression
    Andreas Till
    Institute of Clinical Molecular Biology at the Christian Albrechts University Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Biol Chem 280:5994-6004. 2005
    ..A polymorphism in the TNF receptor 2 (TNFR2) gene resulting in a juxtamembrane inversion from methionine (TNFR2(196MET)) to arginine (TNFR2(196ARG)) has been ..
  52. ncbi Tumour necrosis factor receptors (TNFRs) in Type 2 diabetes. Analysis of soluble plasma fractions and genetic variations of TNFR2 gene in a case-control study
    J Vendrell
    Diabetes and Research Unit, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Diabet Med 22:387-92. 2005
    ..Likewise, we have analysed the genetic susceptibility of 196T > G exon6/CA-repeat intron 4 mutations in the TNFR2 gene in this population.
  53. ncbi Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes
    John R Glossop
    Institute of Science and Technology in Medicine, Keele University
    J Rheumatol 32:1673-8. 2005
    ..To investigate whether polymorphisms in the tumor necrosis factor receptor I (TNFRSF1A) and receptor II (TNFRSF1B) genes are associated with the anemia observed in rheumatoid arthritis (RA)...
  54. ncbi TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury
    Rafia S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    FASEB J 19:1637-45. 2005
    ..cell injury and proliferation, display down-regulation of TNFR1 and activation of ASK1 as well as up-regulation of TNFR2 on tubular cells, where it colocalizes with phosphorylated endothelial/epithelial tyrosine kinase (Etk)...
  55. ncbi Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis
    Juan Sainz
    Unidad de Investigacion, Servicio de Hematologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Hum Immunol 68:41-50. 2007
    ..single nucleotide polymorphisms were investigated: TNF-alpha -308 and +489, LT-alpha +252 and Tumor Necrosis Factor Receptor 2 (TNFR2) +676...
  56. ncbi Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    Exp Gerontol 42:538-44. 2007
    ..Our findings suggest that TNF-RI and -RII promoter gene polymorphisms and variations in protein and gene expression of these receptors are unlikely to play a major role in the development of AD...
  57. doi Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians
    Reeshu Gupta
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Oral Oncol 44:455-63. 2008
    ..chain reaction-restriction fragment length polymorphism (PCR-RFLP) and at four sites of TNF receptor 2 gene (TNFR2; exon 9 site 1176; exon 10 sites 1663, 1668 and 1690) by PCR-sequence-specific primers (PCR-SSP) techniques, ..
  58. doi Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease
    H Matsukura
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Aliment Pharmacol Ther 27:765-70. 2008
    ..The genetic background of the individual may partially explain the differences of the responsiveness...
  59. ncbi Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively
    Hiroko Sashio
    Department of Genetics, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Immunogenetics 53:1020-7. 2002
    ..known as TNFR1), at codon 12 in exon 1 (CCA/CCG), and two SNPs of the 1B gene, TNFRSF1B (also known as TNFR2), (1466 A/G and 1493 C/T)...
  60. ncbi Tumor necrosis factor receptor II gene polymorphism and severity of rheumatoid arthritis
    Arnaud Constantin
    Centre Hospitalier Universitaire Rangueil, INSERM U558, and INSERM U563, Toulouse, France
    Arthritis Rheum 50:742-7. 2004
    The gene encoding tumor necrosis factor receptor type II (TNFRII) is a strong candidate in the pathogenesis of rheumatoid arthritis (RA)...
  61. doi Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study
    Takahiko Horiuchi
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 48:1045-9. 2009
    ..These three genes are involved in the generation of reactive oxygen species (ROS), which play a critical role for autoimmune diseases...
  62. pmc Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor
    H Y Song
    Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis 46202, USA
    Biochem J 309:825-9. 1995
    ..The TRAP identified in the present study shares considerable homology with, and may be the human homologue of, a mouse protein, TNF receptor-associated factor 2 (TRAF2), that binds mouse TNFR-2...
  63. ncbi Cloning, sequencing and partial functional characterization of the 5' region of the human p75 tumor necrosis factor receptor-encoding gene (TNF-R)
    P Kuhnert
    Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel
    Gene 150:381-6. 1994
    A 1887-bp region at the 5' flank of the human p75 tumor necrosis factor receptor (p75 TNF-R)-encoding gene was found to be active in driving expression of the luc (luciferase-encoding) reporter gene, suggesting that it contains the ..
  64. ncbi Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3
    Luzia Maria de Oliveira Pinto
    Department of AIDS and Retroviruses, URA CNRS 1930, Institut Pasteur, Paris, Cedex 15, France
    Blood 99:1666-75. 2002
    ..In this study, we found that both TNFR1 and TNFR2 induced marked apoptosis in peripheral T cells from HIV-infected persons, involving both CD4 and CD8 T cells...
  65. ncbi Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..Our findings suggest that insulin resistance and blood pressure are linked to altered shedding of TNF-alpha receptors in DM-2. The latter seems reversible and is not genetically determined...
  66. ncbi Single-nucleotide polymorphisms in tumor necrosis factor receptor genes: definition of novel haplotypes and racial/ethnic differences
    S Louis Bridges
    University of Alabama at Birmingham
    Arthritis Rheum 46:2045-50. 2002
    ..To characterize allele frequencies of known single-nucleotide polymorphisms (SNPs) in tumor necrosis factor receptor (TNFR) genes in African Americans with rheumatoid arthritis (RA), healthy African Americans, and healthy Caucasians...
  67. ncbi Elevation of serum eosinophil cationic protein, soluble tumor necrosis factor receptors and soluble intercellular adhesion molecule-1 levels in acute bronchial asthma
    Ali Kokuludag
    Division of Immunology, Department of Internal Medicine, Ege University Medical Faculty, Bornova, Izmir, Turkey
    J Investig Allergol Clin Immunol 12:211-4. 2002
    ..In conclusion, high serum levels of sTNF-RI, sTNF-RII and sICAM-1 suggest that these molecules may contribute to the regulation of allergic inflammation and may reflect the severity of inflammation in the airway of asthmatic patients...
  68. ncbi No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis
    John R Glossop
    Staffordshire Rheumatology Centre, The Haywood, Stoke on Trent, Staffordshire, England, UK
    J Rheumatol 30:1406-9. 2003
    ..We investigated whether this particular SNP, and also one at position +36 in exon 1 of the TNF receptor I (TNFRSF1A) gene, are associated with disease severity...
  69. ncbi A TNFR1 genotype with a protective role in familial rheumatoid arthritis
    Philippe Dieude
    GenHotel, Evry Genopole, France
    Arthritis Rheum 50:413-9. 2004
    ..arthritis (RA) have suggested that the tumor necrosis factor receptor I (TNFRI) and TNFRII loci (TNFR1 and TNFR2) are susceptibility loci. A TNFR2 polymorphism was found to be associated with familial RA...
  70. ncbi No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes
    A H M van der Helm-van Mil
    Department of Rheumatology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Rheumatology (Oxford) 43:1232-4. 2004
    To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis.
  71. ncbi Distinct differences between TNF receptor 1- and TNF receptor 2-mediated activation of NFkappaB
    Liv Thommesen
    Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Sør Trøndelag University College, Faculty of Technology, N 7489 Trondheim, Norway
    J Biochem Mol Biol 38:281-9. 2005
    Tumor necrosis factor (TNF) signaling is mediated via two distinct receptors, TNFR2 and TNFR1, which shows partially overlapping signaling mechanisms and biological roles...
  72. ncbi NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B
    N J Macdonald
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch at Galveston, USA
    J Neurosci Res 57:219-26. 1999
    ..NGF also binds to the common neurotrophin receptor (p75(NTR)), a member of the TNFalpha receptor (TNFR-I) superfamily, whose function may be to modulate apoptosis via the ..
  73. ncbi Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease
    M P Look
    Department of General Internal Medicine, University of Bonn, Germany
    AIDS Res Hum Retroviruses 16:1215-21. 2000
    ..e., soluble tumor necrosis factor receptor p75 (sTNFR p75) concentrations. Baseline quinolinic acid (848 nM, 95% CI 567-1130 vs. 303 nM, 95% CI 267.1-339...
  74. pmc The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart
    Jana S Burchfield
    Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Heart Fail 3:157-64. 2010
    Activation of both type 1 and type 2 tumor necrosis factor (TNF) receptors (TNFR1 and TNFR2) confers cytoprotection in cardiac myocytes...
  75. ncbi Distribution of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus infected trigeminal ganglia in the mouse
    E T Cunningham
    The Francis I Proctor Foundation, UCSF, Medical Center, San Francisco, CA 94122 0944, USA
    Brain Res 758:99-106. 1997
    to investigate the distribution of p55 and p75 tumor necrosis factor (TNF) receptor mRNA in normal murine trigeminal ganglia, and in murine trigeminal ganglia acutely infected with McKrae strain herpes simplex virus (HSV).
  76. ncbi Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia
    J M Dopp
    Department of Neurology, UCLA 90095, USA
    J Neuroimmunol 75:104-12. 1997
    ..through low-affinity 55 kDa type-1 receptors (TNFR1, CD120a) and high-affinity 75 kDa type-2 receptors (TNFR2, CD120b)...
  77. ncbi Chronic ethanol enhances ectodomain shedding in T cells and monocytes
    Xue Jun Zhao
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Alcohol Clin Exp Res 28:1399-407. 2004
    ..We hypothesized that chronic ethanol through oxidative stress activates TACE-mediated ectodomain shedding of the preformed substrates p75 and p55 TNF receptors in Mono Mac 6 cells and L-selectin in Jurkat T cells.
  78. ncbi Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Germany
    J Immunol 160:3427-36. 1998
    ..its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75)...
  79. ncbi Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
    R Lucas
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
    Eur J Immunol 27:1719-25. 1997
    ..A significant increase in the expression of TNF-receptor 2 (TNFR2, p75), but not of TNFR1 (p55), was found on brain microvessels at the time of CM in susceptible animals...
  80. ncbi Ligand-induced formation of p55 and p75 tumor necrosis factor receptor heterocomplexes on intact cells
    J K Pinckard
    Department of Pathology, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:10784-9. 1997
    ..Whereas immunoprecipitates from untreated or human TNF-treated cells formed with either p55 or p75 TNF receptor-specific monoclonal antibodies contained only the relevant TNF receptor class, anti-p55 or anti-p75 ..
  81. doi Identification of soluble and membrane-bound isoforms of porcine tumor necrosis factor receptor 2
    Mireia Uribe-Herranz
    New Therapies of Genes and Transplants Group, Institut d Investigacio Biomedica de Bellvitge, IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Xenotransplantation 18:131-46. 2011
    TNF and its receptors TNF-Receptor 1 (TNFR1, CD120a) and TNF-Receptor 2 (TNFR2, CD120b) have been implicated in the rejection of transplanted cells and organs...
  82. pmc Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75
    K C Sheehan
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 181:607-17. 1995
    ..The fourth mAb (55R-286) had no functional effects on cells. Several antibodies specific for the p75 TNF receptor partially inhibited recombinant murine TNF-alpha-dependent cytolytic activity (60%)...
  83. ncbi Endothelial cell contact potentiates release of soluble tumor necrosis factor (TNF) receptors from the monocyte-like cell line THP-1
    F Björnberg
    Department of Hematology, University of Lund, Sweden
    J Interferon Cytokine Res 18:167-74. 1998
    ..Thus, endothelial cell contact potentiates the production of TNF-R75-BP in a monocyte-like cell line. The shedding of soluble TNF receptors observed in this case seems to be a result of both cell attachment and soluble factors...
  84. doi Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway
    Roman Fischer
    Institute of Cell Biology and Immunology, University Stuttgart, Allmandring 31, Stuttgart, Germany
    Cell Signal 23:161-70. 2011
    ..of receptor internalization for signaling as well as the fate and route of internalized TNF receptor 2 (TNFR2; CD120b) is poorly understood...
  85. ncbi TNF-Induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase
    P Dri
    Department of Physiology and Pathology, University of Trieste, Trieste, Italy
    J Immunol 165:2165-72. 2000
    ..The possibility that ADAM-17, which we show to be expressed in neutrophils, might be the involved proteinase is discussed...
  86. ncbi Preferential induction of prodestructive matrix metalloproteinase-1 and proinflammatory interleukin 6 and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts via tumor necrosis factor receptor-55
    Saifeddin Alsalameh
    Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Rheumatol 30:1680-90. 2003
    ..To assess expression and individual functional relevance of tumor necrosis factor receptor 55 (TNF-R55) and TNF-R75 in rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFB)...
  87. ncbi Red blood cell Na-Li countertransport, hypertensive heredity, and cardiovascular risk in young adults
    J M Krzesinski
    University of Liege, Belgium
    Am J Hypertens 6:314-6. 1993
    ..people according to the blood pressure level during adolescence in two groups, one lower than the 75th percentile (P75), and one higher, we notice that the latter remains characterized by a higher systolic blood pressure...
  88. ncbi Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling
    L C Gerstenfeld
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Mass, USA
    Cells Tissues Organs 169:285-94. 2001
    ..were carried out in the tibiae of both wild-type and knock-out mice in which both TNF-alpha receptors (p55(-/-)/p75(-/-)) had been ablated...
  89. ncbi Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients
    J M Fernandez-Real
    Diabetes Unit, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Barcelona, Spain
    Diabetes Care 23:831-7. 2000
    Mice lacking the tumor necrosis factor-alpha receptor 2 (TNFR2) gene fed a high-fat diet gain less weight and display reduced leptin and insulin levels...
  90. ncbi The correlation of cytokine levels with body weight after megestrol acetate treatment in geriatric patients
    S S Yeh
    Department of Medicine, VA Medical Center at Northport, New York 11768, USA
    J Gerontol A Biol Sci Med Sci 56:M48-54. 2001
    ..This study evaluates the correlation between changes in cytokine (or their receptor) levels and weight following MA treatment in geriatric weight-loss patients...
  91. ncbi Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA
    M Rende
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia School of Medicine, Italy
    Int J Dev Neurosci 18:869-85. 2000
    ..During differentiation, muscle cells also express some neurotrophin receptors, such as the low-affinity p75 neurotrophin receptor, which binds all neurotrophins, and the high affinity tyrosine kinase receptor TrKA, nerve ..
  92. ncbi Expression and significance of nerve growth factor receptor p75 in rats' cathartic colonic wall
    Yi Hong Fan
    Department of Gastroenterology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China
    Chin J Dig Dis 7:225-9. 2006
    To investigate the expression of nerve growth factor receptor p75 in a normal and cathartic colon and its significance in the formation of the cathartic colon in rats.
  93. ncbi Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 119:191-204. 1998
    ..Also low-affinity nerve growth factor receptor (p75) and growth-associated protein-43 (GAP-43) mRNAs were upregulated during the entire 3-week period...
  94. ncbi Sensory evoked potentials in unanesthetized unrestrained cuttlefish: a new preparation for brain physiology in cephalopods
    T H Bullock
    Neurobiology Unit, Scripps Institution of Oceanography, University of California, San Diego, La Jolla
    J Comp Physiol A 168:141-50. 1991
    ..35 ms (called P35), followed by ca. P75, P95, N110 and smaller waves or oscillations lasting more than 0.5 s...
  95. doi Schwann cell p75NTR prevents spontaneous sensory reinnervation of the adult spinal cord
    Angela L M Scott
    Blusson Spinal Cord Centre, Vancouver, BC V5Z 1M9, Canada
    Brain 133:421-32. 2010
    ..cell activation such as that which accompanies peripheral nerve injury results in massive upregulation of the p75(NTR) pan-neurotrophin-receptor...
  96. ncbi A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro
    Peter Andrews
    Department of Cell Biology, Georgetown University School of Medicine, 3900 Reservoir Road, NW, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 61:203-14. 2008
    ..Chemother Pharmacol 502:77-284, 2002), and that this observed effectiveness is mediated by an up-regulation of the p75 NTR tumor suppressor (Khwaja et al. in Cancer Res 646:207-6213, 2004)...
  97. pmc Hepatocyte growth factor is a mitogen for olfactory ensheathing cells
    H Yan
    Department of Neurology, Yale University School of Medicine, Neuroscience Research Center, VA Medical Center, West Haven, Connecticut 06516, USA
    J Neurosci Res 66:698-704. 2001
    ..from adult rat olfactory bulbs and cultured in serum-free medium, and were identified by double immunostaining for p75 and S-100 antibodies...
  98. ncbi Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
    Clin Cancer Res 7:3457-64. 2001
    ..this study was to analyze the expression of the high- and low-affinity nerve growth factor (NGF) receptors TrkA and p75 in effusions and in primary and metastatic tumors of serous ovarian carcinoma patients, as well as to evaluate ..
  99. ncbi Overexpressions of nerve growth factor and its tropomyosin-related kinase A receptor on chordoma cells
    Jong Beom Park
    Department of Orthopaedic Surgery, Catholic University of Korea School of Medicine, Seoul, Korea
    Spine (Phila Pa 1976) 32:1969-73. 2007
    ..Immunohistochemistry and in situ apoptosis detection assay were performed on chordoma and notochordal cells...
  100. ncbi Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR
    B T Fundin
    Department of Anatomy, Uppsala University, Sweden
    Dev Biol 190:94-116. 1997
    ..NT-4), the three tyrosine kinase receptors (trkA, trkB, trkC), and the low-affinity nerve growth factor receptor p75. Specimens were sacrificed at birth and at 1, 2, and 4 weeks for each type of mutation as well as at 11 weeks and 1 ..
  101. ncbi Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Breast Cancer Res Treat 83:119-28. 2004
    ..of the expression of nerve growth factor (NGF) and its receptors phospho-TrkA (p-TrkA activated receptor) and p75. Sections from 42 malignant pleural effusions from breast cancer patients and 65 corresponding solid tumors (34 ..

Research Grants64

  1. TNF receptor-2 signaling in arteriogenesis/angiogenesis
    Wang Min; Fiscal Year: 2010
    ..two distinct TNF-specific plasma membrane-localized receptors, type I 55 kDa TNFR (TNFR1) and type II 75 kDa TNFR (TNFR2)...
  2. Regulation of neurotransmitter properties by target-derived neurotrophic factors
    Susan J Birren; Fiscal Year: 2010
    ..NGF promotes noradrenergic transmission via activation of Trk receptors. In contrast, BDNF acts through the p75 receptor to increase activity-dependent acetylcholine release...
  3. Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells
    Jeffrey L Spees; Fiscal Year: 2012
    ..show that serum-free medium conditioned by mixed MSCs or by standardized MSCs isolated by magnetic sorting for the p75 low affinity nerve growth factor receptor (p75LNGFR;p75MSCs) can support the growth and survival of adult cardiac ..
  4. MECHANISMS OF ESTROGEN ACTION IN THE DEVELOPING CNS
    Dominique Toran Allerand; Fiscal Year: 2000
    ..neurotrophic factor (BDNF); neurotrophin-3 (NT-3)] are essential for regulation of the estrogen and neurotrophin (p75 and trk family) receptor genes and for estrogen signaling pathways...
  5. Giovanni Piedimonte; Fiscal Year: 2016
    ..inflammation through mechanisms involving the increased expression of nerve growth factor (NGF) and its trkA and p75 receptors, and we have confirmed overexpression of neurotrophic factors [NGF and brain-derived neurotrophic factors ..
  6. Frank B Hu; Fiscal Year: 2016
    ..leptin, soluble leptin receptor (sOB-R), insulin, adiponectin, retinol binding protein 4 [RBP4], tumor necrosis factor receptor 2 [TNF-R2], and interleukin 6 [IL-6]) among 1,000 healthy NHS II participants who provided repeated ..
  7. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..reperfusion and ventricular remodeling;their actions are regulated by soluble Type I/Type II TNF receptor (TNFR1/TNFR2), IL-1 receptor antagonist (IL-1ra), and IL-18 binding protein (IL-18bp), respectively...
  8. DOUGLAS LOWELL MANN; Fiscal Year: 2016
    ..that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  9. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  10. Paul L Fox; Fiscal Year: 2016
    ..The goal of Project 3, led by Dr. Paul DiCorleto, is to understand the role of the tumor necrosis factor receptor p75 and the transcription factor HOXA9 in the transcriptional regulation of pro-inflammatory genes in endothelial cells...
  11. CD8+ T CELL APOPTOSIS IN HIV INFECTION
    Georges Herbein; Fiscal Year: 2000
    ..Following interaction of CXCR4 with the HIV envelope gp120, tumor necrosis factor receptor 2 (TNFR2) is up-regulated on Cd8+ T cells and tumor necrosis factor alpha (TNF) stimulation provided by ..
  12. MOSES VICTOR CHAO; Fiscal Year: 2016
    ..exert trophic and synaptic effects through the actions of two different receptors, Trk tyrosine kinases and the p75 neurotrophin receptor...
  13. p75 Expression for Assessing Neurotoxicity
    William Valentine; Fiscal Year: 2003
    ..The low affinity nerve growth factor receptor (p75) has been most extensively characterized and has exhibited the greatest increases and longest duration of elevated ..
  14. Italo Mocchetti; Fiscal Year: 2016
    ..effects are reproduced by the proneurotrophin brain-derived neurotrophic factor (proBDNF) and are mediated by the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor family...
  15. Beth A Habecker; Fiscal Year: 2016
    ..exert their effects on sympathetic neurons through two receptors, the TrkA tyrosine kinase receptor and the p75 receptor...
  16. Chuanju Liu; Fiscal Year: 2016
    ..PGRN directly binds to TNFR2 with an approximately 600-fold higher affinity than TNF?, and PGRN-activated target gene expressions in ..
  17. Cytokine Driven Mechanisms of Vein Graft Failure
    C Ozaki; Fiscal Year: 2009
    ..by soluble receptors, adeno-associated virus (AAV)-delivered TNF receptor homologs, specific p55 or p75 TNF receptor antibodies, or TNF-o_ converting enzyme inhibition...
  18. KIMBERLY S WILLIAMS; Fiscal Year: 2014
    ..The proposed studies will expand on ongoing research exploring how neurotrophin signaling through the p75 and TrkA receptors may suppress the neurotoxic activity of these cells with the intent of developing a novel ..
  19. Genetic mosaic analysis of neurotrophin signaling in neuronal morphogenesis and r
    WILLIAM J JOO; Fiscal Year: 2012
    ..combine inducible genetic strategies and genetic mosaic analysis to test the function of neurotrophin receptors p75, TrkB, and TrkC in development and refinement of central somatosensory circuitry...
  20. MECHANISMS OF NEUROTROPHIN RECEPTOR CROSSTALK
    RICK DOBROWSKY; Fiscal Year: 2002
    ..In addition, it appears that p75 can increase the activity of Trk, and in contrast, that Trk can silence p75 signaling; that is, there seems to be ..
  21. Mechanisms and Neural Consequences of Estrogen Action
    Farida Sohrabji; Fiscal Year: 2005
    ..In the adult forebrain, estrogen increases trk receptors and decreases p75, resulting in a favorable trk/p75 ratio, while in the reproductively senescent forebrain, estrogen replacement, ..
  22. ASHLESH KRISHNA MURTHY; Fiscal Year: 2016
    ..TNF-a induces pleotrophic effects including apoptosis via two main receptors, TNF receptor 1 (TNFR1) and TNFR2, which have been shown to complement or oppose the effects of each other in different infection models...
  23. GROWTH FACTORS AND INFLAMMATORY BOWEL DISEASE
    Pauline K Lund; Fiscal Year: 2013
    ..silencing promotes tumorigenesis by limiting excessive or aberrant activation of STATs, NFkB and TNF receptor 2 (TNFR2)...
  24. TNF SIGNALING IN THE ABSENCE OF FUNCTIONAL TNF RECEPTORS.
    EDOUARD M CANTIN; Fiscal Year: 2012
    ..studies, we showed that B6 mice genetically deleted for either or both of the known TNF receptors TNFR1 or p55 and TNFR2, or p75 were resistant to fatal HSV infection...
  25. P75NTR Small Molecule Ligands for Down Syndrome Therapy
    Frank M Longo; Fiscal Year: 2013
    ..The current proposal will test whether small molecule ligands for the p75 neurotrophin receptor (p75NTR) will be effective treatments for neurodegeneration associated with Down syndrome (DS)..
  26. TNF Processing in Pulmonary Immunopathology
    Richard I Enelow; Fiscal Year: 2011
    ..This appears to mediated by TNF-R2 (p75) leading to exuberant ERK activation and Egr-1 expression...
  27. Immunocytoprotection in collapsing glomerulopathy
    PETER JACOB NELSON; Fiscal Year: 2013
    ..Towards this end, we have identified the interaction of TNF-[unreadable] with TNF receptor 2 (TNFR2) on podocytes as a potential precipitant of CG...
  28. Grant D Nicol; Fiscal Year: 2015
    ..demonstrated that NGF/BDNF can rapidly increase the ability of sensory neurons to fire action potentials (APs) via p75 neurotrophin receptor (p75NTR) activation of the sphingolipid signaling cascade...
  29. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2012
    ..BDNF and NT4, can influence various aspects of neural innervation through the same receptors, TrkB and p75. The proposed studies use cell counting, tract tracing, immunohistochemistry and scanning electron microscopy in ..
  30. Signaling mechanisms of axon regeneration by CNS myelin
    Zhigang He; Fiscal Year: 2009
    ..across the axonal membrane mediated by two transmembrane co-receptors, including a TNF receptor family member p75 and a newly-identified transmembrane protein Lingo-1...
  31. Mechanisms of Redox Mediated Cardioprotection
    Daret St Clair; Fiscal Year: 2006
    ..to ADR-induced cardiac injury and that pre-treatment with TAM results in a dose-dependent reduction of the p75 TNF receptor and suppression of TNFalpha-induced mitochondrial injury...
  32. Sex differences in TNFR2 signaling mechanisms following acute surgical ischemia
    Brent Weil; Fiscal Year: 2009
    ..The role that TNF receptor 2 (TNFR2) may play in facilitating TNFR1 signaling resistance, however, has yet to be elucidated...
  33. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
    ..effects through distinct signaling cascades associated with TNF receptor-type I (TNFR1) and -type II (TNFR2)...
  34. John R Grider; Fiscal Year: 2016
    ..In AIM 2, we will use pharmacological, biochemical, and molecular tools to identify the receptors (TrkB, p75, and sortilin) and intracellular signaling pathways (PLC-gamma, PI-3-K/AKT, ERK1/2, Rho/Rock) activated by proBDNF ..
  35. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..In AIM 2, we will use pharmacological, biochemical, and molecular tools to identify the receptors (TrkB, p75, and sortilin) and intracellular signaling pathways (PLC-gamma, PI-3-K/AKT, ERK1/2, Rho/Rock) activated by proBDNF ..
  36. The Role of Local BDNF Synthesis in Spine Morphogenesis
    LAUREN LYNN OREFICE; Fiscal Year: 2012
    ..I hypothesize that activity induces dendritic translation and secretion of proBDNF, which interacts with p75[NTR] to mediate spine pruning through RhoA in cultured hippocampal neurons...
  37. D Brent Polk; Fiscal Year: 2016
    ..project is focused on understanding the roles played by tumor necrosis factor (TNF) and its receptors (TNFR1 &TNFR2) in coordinating proliferation and apoptosis during intestinal epithelial injury and inflammation...
  38. Chuanju Liu; Fiscal Year: 2015
    ..global screen for the binding proteins of progranulin (PGRN) growth factor, we found that PGRN bound to TNFR1 and TNFR2. Subsequent studies demonstrated that PGRN protected regulatory T cells (Treg) from negative regulation by TNF?;..
  39. CONTROL OF TNF SIGNALING BY NFKB
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..The effects of TNFalpha are mediated by two distinct cell surface receptors, p55 TNF-R1 and p75 TNF-R2, that are expressed on almost all cells...
  40. TNF alpha Signaling: Effects on AMPA Receptor Location
    ERIC BEATTIE; Fiscal Year: 2007
    ..Specific aim 1 will determine if signaling from one of the two TNF-alpha receptors- TNFR1, TNFR2, or both contribute to increased AMPAR surface localization...
  41. Robert W McCarley; Fiscal Year: 2016
    ..The selective toxin mu p75-saporin will be used to investigate the role of cholinergic BF neurons in the regulation of wakefulness, and the ..
  42. DESIGN AND SYNTHESIS OF FUNCTIONAL NGF PEPTIDOMIMETICS
    Kevin Burgess; Fiscal Year: 2009
    ..because of cost, proteolytic instability, immune responses, and, notably, its interactions with other receptors (p75, and other Trk's) causing undesirable side effects...
  43. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    Richard E Zigmond; Fiscal Year: 2010
    ..produces its effects on the intrinsic growth properties of sympathetic neurons by down-regulating BDNF- and p75-mediated inhibition of neurite outgrowth, and we will test this hypothesis by (a) determining the impact of ..
  44. Neurotrophin mimetic therapeutics for HIV-associated neural dysfunction
    Rick B Meeker; Fiscal Year: 2013
    ..These compounds are targeted to specific epitopes of the p75 neurotrophin receptor (p75NTR) or receptor tyrosine kinase B (TrkB), thereby allowing a greater degree of control ..
  45. Bruce D Carter; Fiscal Year: 2014
    ..One key regulator of neuronal death and degeneration is the p75 neurotrophin receptor...
  46. P75 Small Molecule Ligands for Alzheimer's Therapy
    Frank M Longo; Fiscal Year: 2012
    ..that specifically target a cell surface receptor that is expressed by neurons affected in AD, known as the p75 receptor...
  47. Helen E Scharfman; Fiscal Year: 2014
    ..suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 and sortilin to initiate neuronal death...
  48. Multipotent mesenchymal stem cell-like cells in pancreatic tumorigenesis
    NADEZDA ALEKSANDROVNA ISACHENKO; Fiscal Year: 2012
    ..While there are many signaling pathways and factors that would be worthwhile and important to assess, I decided to focus on PDGFR2 and CD271/p75 as a potential regulators of MPMSC differentiation into pericytes.
  49. Regulating BDNF Action in Postnatal Development.
    Barbara L Hempstead; Fiscal Year: 2013
    ..When proBDNF is released at the synapse, it can bind to p75 receptors to induce LTD, and potentially reduce spine density and dendritic complexity...
  50. Frank M Longo; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): This application titled "Small Molecule p75 Neurotrophin Receptor Ligand to Treat Huntington's Disease" is in response to NINDS Exploratory/Developmental Projects in Translational Research (R21;..
  51. Genetic analysis of the neurotrophin receptor p75 in neural development
    Kuo Fen Lee; Fiscal Year: 2012
    The long-term goal of this project is to understand the role of the neurotrophin receptor p75 in neural development and regeneration...
  52. Barbara L Hempstead; Fiscal Year: 2014
    ..However, proneurotrophins, including proBDNF, exert independent cell fate decisions by activating the p75 receptor and sortilin, to mediate cell death...
  53. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2013
    ..of the factors with two distinct receptors, a member of the Trk family of receptor tyrosine kinases and the p75 neurotrophin receptor (NTR)...
  54. Rick B Meeker; Fiscal Year: 2016
    ..In independent studies of HIV neuropathogenesis and aging we have demonstrated that the novel p75 neurotrophin ligand, LM11A-31, prevents neural dysfunction and damage, in part, by restoring calcium homeostasis...
  55. The Role of Presenilins in HIV Associated Dementia
    Suman Jayadev; Fiscal Year: 2010
    ..The PS y-secretase complex also cleaves numerous substrates such as ErbB4, Notch, p75 that have been implicated in inflammatory processes...
  56. MOSES VICTOR CHAO; Fiscal Year: 2015
    ..The actions of neurotrophins are dictated by two cell surface receptors, Trk tyrosine kinases and the p75 receptor...
  57. Role of C-myb in Hematopoiesis and Cancer
    E Premkumar Reddy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): It is now well established that the c-myb gene encodes for two proteins, p75-Myb and p89-Myb, and plays a critical role in the development, proliferation and oncogenesis of hematopoietic cells...
  58. Gerald J Taborsky; Fiscal Year: 2014
    ..balance of islet neurotrophins away from "axonal maintenance" via Trk receptors towards "axonal pruning" via the p75 pan-neurotrophin receptor (NTR), causing a selective loss of islet sympathetic nerves and thereby dysfunction of ..
  59. Herman S Cheung; Fiscal Year: 2014
    ..study showed that cells isolated from adult human PDL expressed ESC markers ( Oct4, Nanog, Sox2) and NC markers (p75, Nestin, Sox10), and exhibited the potential to differentiate into all 3 germ layers...
  60. Fang Yan; Fiscal Year: 2016
    ..We have successfully purified and cloned two novel LGG-derived soluble proteins (p40 and p75) that prevent cytokine-induced apoptosis through activating Akt in intestinal epithelial cells...
  61. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..and tissue (adipose tissue and skeletal muscle) inflammation (secretion, expression, and cytokine receptor TNFR1, TNFR2, adipoR1, adipoR2 expression) are disturbed in chronic stroke compared to age, sex, BMI, race, and risk-factor ..
  62. Elizabeth W Karlson; Fiscal Year: 2016
    ..breastfeeding, early menarche, and irregular menses, inflammatory markers including anti-CCP antibodies, and TNFR2 levels and a novel RA risk allele in the prolactin gene as significant risk factors for RA...
  63. HIV integrase/DNA complexes and concerted integration
    Duane P Grandgenett; Fiscal Year: 2010
    ..The cellular co- factor, LEDGF/p75, influences the ability of the PIC to select sites on the host chromosomes for integration...
  64. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..that TNF itself may have beneficial or detrimental effects depending on which of its receptors (TNFR1 or TNFR2) is activated...