TNFR1

Summary

Gene Symbol: TNFR1
Description: TNF receptor superfamily member 1A
Alias: CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF-R1, TNF-RI, TNFR-I, tumor necrosis factor binding protein 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor type 1, tumor necrosis factor-alpha receptor
Species: human

Top Publications

  1. pmc c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 283:24295-9. 2008
  2. doi Clinical and functional characterisation of a novel TNFRSF1A c.605T>A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etaner
    S Stojanov
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann Rheum Dis 67:1292-8. 2008
  3. doi Quantitative flow cytometric analysis of expression of tumor necrosis factor receptor types I and II on mononuclear cells
    Julia A Lopatnikova
    Laboratory of Molecular Immunology, Federal State Budgetary Institution Research Institute of Clinical Immunology, Russian Academy of Medical Sciences Siberian Branch, Novosibirsk, Russia
    J Recept Signal Transduct Res 33:49-55. 2013
  4. ncbi Late-onset tumor necrosis factor receptor-associated periodic syndrome in multiple sclerosis patients carrying the TNFRSF1A R92Q mutation
    Tania Kümpfel
    Institute of Clinical Neuroimmunology Grosshadern, Ludwig Maximilian University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Arthritis Rheum 56:2774-83. 2007
  5. ncbi Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:6578-83. 1997
  6. ncbi Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3
    Luzia Maria de Oliveira Pinto
    Department of AIDS and Retroviruses, URA CNRS 1930, Institut Pasteur, Paris, Cedex 15, France
    Blood 99:1666-75. 2002
  7. ncbi The enlarging clinical, genetic, and population spectrum of tumor necrosis factor receptor-associated periodic syndrome
    Catherine Dode
    Hopital Cochin, Institut Cochin, and Institut fédéritif de recherche, de l INSERM, Universite Paris V, Paris, France
    Arthritis Rheum 46:2181-8. 2002
  8. ncbi Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
    Nicole Cusson-Hermance
    Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:36560-6. 2005
  9. doi A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children
    M Gattorno
    Giannina Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1823-32. 2008
  10. doi Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: conformational stabilization of CRD2 and control of receptor responsiveness
    Marcus Branschädel
    University of Stuttgart, Institute of Cell Biology and Immunology, Allmandring 31, D 70569 Stuttgart, Germany
    Cell Signal 22:404-14. 2010

Research Grants

  1. Astar Winoto; Fiscal Year: 2016
  2. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
  3. DOUGLAS LOWELL MANN; Fiscal Year: 2016
  4. Steven L Gonias; Fiscal Year: 2014
  5. Clayton E Mathews; Fiscal Year: 2015
  6. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
  7. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
  8. TRADD as a Regulator of Cytokine Signaling in Glia
    ETTY BENVENISTE; Fiscal Year: 2009
  9. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
  10. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010

Patents

  1. Tumour necrosis factor - alpha binding protein

Detail Information

Publications255 found, 100 shown here

  1. pmc c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 283:24295-9. 2008
    ..c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1)-associated complexes where they can regulate receptor-mediated signaling...
  2. doi Clinical and functional characterisation of a novel TNFRSF1A c.605T>A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etaner
    S Stojanov
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann Rheum Dis 67:1292-8. 2008
    ..To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site...
  3. doi Quantitative flow cytometric analysis of expression of tumor necrosis factor receptor types I and II on mononuclear cells
    Julia A Lopatnikova
    Laboratory of Molecular Immunology, Federal State Budgetary Institution Research Institute of Clinical Immunology, Russian Academy of Medical Sciences Siberian Branch, Novosibirsk, Russia
    J Recept Signal Transduct Res 33:49-55. 2013
    ....
  4. ncbi Late-onset tumor necrosis factor receptor-associated periodic syndrome in multiple sclerosis patients carrying the TNFRSF1A R92Q mutation
    Tania Kümpfel
    Institute of Clinical Neuroimmunology Grosshadern, Ludwig Maximilian University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Arthritis Rheum 56:2774-83. 2007
    ..We undertook this study to investigate the prevalence of TRAPS in patients with multiple sclerosis (MS) who reported, in addition to their neurologic symptoms, at least 2 other symptoms compatible with TRAPS...
  5. ncbi Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:6578-83. 1997
    ..Consistent with this finding, FLICE2 is recruited to both the CD95 and p55 tumor necrosis factor receptor signaling complexes in a FADD-dependent manner...
  6. ncbi Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3
    Luzia Maria de Oliveira Pinto
    Department of AIDS and Retroviruses, URA CNRS 1930, Institut Pasteur, Paris, Cedex 15, France
    Blood 99:1666-75. 2002
    ..In this study, we found that both TNFR1 and TNFR2 induced marked apoptosis in peripheral T cells from HIV-infected persons, involving both CD4 and CD8 T ..
  7. ncbi The enlarging clinical, genetic, and population spectrum of tumor necrosis factor receptor-associated periodic syndrome
    Catherine Dode
    Hopital Cochin, Institut Cochin, and Institut fédéritif de recherche, de l INSERM, Universite Paris V, Paris, France
    Arthritis Rheum 46:2181-8. 2002
    ..To characterize the frequency, clinical signs, and genotypic features of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a series of 394 patients of various ethnic origins who have recurrent inflammatory syndromes...
  8. ncbi Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
    Nicole Cusson-Hermance
    Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:36560-6. 2005
    ..These studies suggest that Rip1 uses a similar, ubiquitin-dependent mechanism to activate IkappaB kinase-beta in response to TNF-alpha and TLR3 ligands...
  9. doi A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children
    M Gattorno
    Giannina Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1823-32. 2008
    ..To identify a set of clinical parameters that can predict the probability of carrying mutations in one of the genes associated with hereditary autoinflammatory syndromes...
  10. doi Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: conformational stabilization of CRD2 and control of receptor responsiveness
    Marcus Branschädel
    University of Stuttgart, Institute of Cell Biology and Immunology, Allmandring 31, D 70569 Stuttgart, Germany
    Cell Signal 22:404-14. 2010
    ..Both TNF receptors, TNFR1 and TNFR2, contain four cysteine rich domains (CRD) in their extracellular parts...
  11. ncbi Association of the R92Q TNFRSF1A mutation and extracranial deep vein thrombosis in patients with Behçet's disease
    Zahir Amoura
    Hopital Pitie Salpetriere, Paris, France
    Arthritis Rheum 52:608-11. 2005
    ..One of the 2 TNFalpha receptors is TNF receptor superfamily 1A (TNFRSF1A). We searched for R92Q TNFRSF1A mutations in patients with Behçet's disease...
  12. doi Incidence of TNFRSF1A mutations in German children: epidemiological, clinical and genetic characteristics
    Elke Lainka
    Department of Paediatric Rheumatology, Children s Hospital, University Duisburg Essen, Essen, Germany
    Rheumatology (Oxford) 48:987-91. 2009
    ..We aim to determine the incidence of TRAPS and the spectrum of mutations in the TNFRSF1A gene, and to give a brief survey of clinical signs...
  13. ncbi Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13 [corrected]
    P Fuchs
    Department of Molecular Biology, Ernst Boehringer Institut, Bender Co GmbH, Vienna, Austria
    Genomics 13:219-24. 1992
    ..the entire coding and 3' untranslated region of the human type I tumor necrosis factor receptor (p60) gene (TNFR1) were isolated by hybridization using probes derived from TNFR-1 cDNA...
  14. ncbi Chromosomal location of the human tumor necrosis factor receptor genes
    E Baker
    Department of Cytogenetics and Molecular Genetics, Adelaide Children s Hospital, North Adelaide, Australia
    Cytogenet Cell Genet 57:117-8. 1991
    b>TNFR1 and TNFR2, the genes encoding the two forms of the human tumor necrosis factor receptor, were localized to normal human chromosomes by in situ hybridization and Southern blot analysis of a series of human x mouse hybrid cell lines...
  15. ncbi Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors
    H Engelmann
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    J Biol Chem 265:1531-6. 1990
    ..The findings presented in this study are consistent with the notion that the urinary TNF-binding proteins constitute soluble forms of the two molecular species of the cell surface TNF receptors...
  16. ncbi Familial Hibernian fever
    L M Williamson
    Q J Med 51:469-80. 1982
    ..The disease appears to have a benign course and no patient has developed amyloid...
  17. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1 (TNFR1)...
  18. ncbi TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
    ..TNF) can induce apoptosis and activate NF-kappa B through signaling cascades emanating from TNF receptor 1 (TNFR1). TRADD is a TNFR1-associated signal transducer that is involved in activating both pathways...
  19. ncbi TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 4:387-96. 1996
    The death domain of tumor necrosis factor (TNF) receptor-1 (TNFR1) triggers distinct signaling pathways leading to apoptosis and NF-kappa B activation through its interaction with the death domain protein TRADD...
  20. ncbi FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase
    S Adam-Klages
    Institut fur Immunologie, Christian Albrechts Universitat Kiel, Federal Republic of Germany
    Cell 86:937-47. 1996
    ..The data suggest that FAN regulates ceramide production by N-SMase, which is a crucial step in TNF signaling...
  21. ncbi Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling
    S Schutze
    Institute of Immunology, University of Kiel, 24105 Kiel, Germany
    J Biol Chem 274:10203-12. 1999
    ..We show that MDC does not prevent the interaction of the p55 TNF receptor (TR55) with FAN and TRADD...
  22. ncbi Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    M F McDermott
    Medical Unit, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, Whitechapel, London, England
    Cell 97:133-44. 1999
    ..seven affected families, we found six different missense mutations of the 55 kDa tumor necrosis factor receptor (TNFR1), five of which disrupt conserved extracellular disulfide bonds...
  23. ncbi Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance
    E Aganna
    Unit of Molecular Medicine, Department of Diabetes and Metabolic Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    Eur J Hum Genet 9:63-6. 2001
    ..As this R92P mutation is present in two unaffected carriers it appears to be less penetrant than previously reported TNFRSF1A mutations involving cysteine residues in the extracellular domains...
  24. pmc The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers
    I Aksentijevich
    Section of Genetics, Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 69:301-14. 2001
    ....
  25. ncbi Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease
    R A Allen
    Blackpool Victoria Hospital, Whinney Heys Road, Blackpool, UK
    Eur J Clin Invest 31:843-51. 2001
    ..We have therefore investigated whether polymorphisms in the TNF-alpha (- 238 and - 308), TNF receptor 1 (position - 609 and + 10, intron 6) and TNF receptor 2 (position + 422, codon 198) genes show an association with CAD...
  26. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the adaptor FADD and caspase-8 to the receptor complex...
  27. ncbi Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis
    E Aganna
    Department of Diabetes and Metabolic Medicine, Barts and London, Queen Mary s School of Medicine and Dentistry, Whitechapel, London, UK
    Genes Immun 5:289-93. 2004
    ..Although allelic variants in HPFs genes are not major susceptibility factors for AA amyloidosis in chronic inflammatory disease, low-penetrance variants of MEFV and TNFRSF1A may have clinically significant proinflammatory effects...
  28. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..ubiquitin chains from receptor interacting protein (RIP), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex...
  29. ncbi Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor-associated periodic syndrome is altered antigenically and is retained within patients' leukocytes
    Ian Todd
    Division of Immunology, Queen s Medical Center, University of Nottingham, Derby Road, Nottingham, UK
    Arthritis Rheum 56:2765-73. 2007
    To investigate the effect of mutations in tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in TNFR-associated periodic syndrome (TRAPS) on the binding of anti-TNFRSF1A monoclonal antibodies (mAb), and to investigate the ..
  30. ncbi IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    Cell 131:682-93. 2007
    ..Cells treated with an IAC, or those in which cIAP1 was deleted, became sensitive to apoptosis induced by exogenous TNFalpha, suggesting novel uses of these compounds in treating cancer...
  31. doi Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome
    Belinda Nedjai
    Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, UK
    Arthritis Rheum 58:273-83. 2008
    ....
  32. doi TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression
    Sun Kim
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Laboratory of Genome Research, 388 1 Pungnap 2 dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Biochem Biophys Res Commun 368:395-401. 2008
    ..In particular, we found that the TNFR1 promoter -329G/T polymorphism was strongly associated with primary HCC (odds ratio [OR]=5.22, p=0.0007)...
  33. ncbi Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity
    Roxana Pincheira
    Department of Surgery and Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    J Immunol 181:1288-98. 2008
    The type 1 TNFR (TNFR1) contains a death domain through which it interacts with other death-domain proteins to promote cellular responses...
  34. doi Increased serum levels of inflammatory markers in chronic institutionalized patients with schizophrenia
    Fernanda Matos Coelho
    Group of Neuroimmunology, Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Neuroimmunomodulation 15:140-4. 2008
    ..However, associations between the levels of cytokines and the severity of symptoms have not been completely established...
  35. doi Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
    Kim Newton
    Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell 134:668-78. 2008
    ..Polyubiquitin editing may therefore be a general mechanism for attenuating innate immune signaling...
  36. doi Novel markers of inflammation identified in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) by transcriptomic analysis of effects of TRAPS-associated tumor necrosis factor receptor type I mutations in an endothelial cell line
    Susana L Rebelo
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, and Queen s Medical Centre, Nottingham, UK
    Arthritis Rheum 60:269-80. 2009
    ....
  37. doi Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation
    A Wicovsky
    Department of Internal Medicine II, Division of Molecular Internal Medicine, University Hospital Wurzburg, Wurzburg, Germany
    Oncogene 28:1769-81. 2009
    ..receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NFkappaB and JNK...
  38. pmc Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    Young Sik Cho
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 137:1112-23. 2009
    ..Our findings suggest that RIP3 controls programmed necrosis by initiating the pronecrotic kinase cascade, and that this is necessary for the inflammatory response against virus infections...
  39. pmc Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    Philip L De Jager
    Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 41:776-82. 2009
    ....
  40. doi Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis
    Midori Hasegawa
    Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Nephron Clin Pract 113:c222-33. 2009
    ..necrosis factor (TNF) receptors in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, we evaluated the cell surface expression of TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2).
  41. doi Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis
    Tania Kümpfel
    Institute of Clinical Neuroimmunology Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, Munich, Germany
    Nat Rev Neurol 5:528-9. 2009
    ..This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS...
  42. pmc Multiple sclerosis susceptibility alleles in African Americans
    B A Johnson
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Genes Immun 11:343-50. 2010
    ..None of the tested variants showed results that were statistically inconsistent with the effects established in whites. The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry...
  43. ncbi Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome
    L Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Int J Immunopathol Pharmacol 22:1051-8. 2009
    ..A poor response to colchicine treatment and/or a steroid-dependence may be the clue to investigate TNFRSF1A mutations in patients with idiopathic recurrent pericarditis...
  44. doi Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer
    Eung Bae Lee
    Department of Thoracic Surgery, Kyungpook National University Hospital, Daegu, Korea
    Ann Surg Oncol 17:2608-18. 2010
    ..This study was conducted to determine the association between single-nucleotide polymorphisms (SNPs) in apoptosis-related genes and survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC)...
  45. pmc Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
    Anna Simon
    Inflammatory Biology Section, Laboratory of Clinical Investigation and Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:9801-6. 2010
    TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases...
  46. ncbi TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis
    J Sainz
    Experimental Research Unit, Virgen de las Nieves University Hospital, Granada, Spain
    Int J Immunopathol Pharmacol 23:423-36. 2010
    ..TNF acts through TNF receptor 1 (TNFR1) triggering a pro-inflammatory response, and therefore plays a pivotal role in immune regulation and host immune ..
  47. doi Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese
    Stuart I Davidson
    The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Ann Rheum Dis 70:289-92. 2011
    ..A candidate gene study in a Han Chinese population was performed based on these findings to identify associated genes in this population...
  48. pmc Long-term clinical profile of children with the low-penetrance R92Q mutation of the TNFRSF1A gene
    M A Pelagatti
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 63:1141-50. 2011
    ....
  49. pmc Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    George F Mells
    Academic Department of Medical Genetics, Cambridge University, Cambridge, UK Department of Hepatology, Cambridge University Hospitals National Health Service NHS Foundation Trust, Cambridge, UK
    Nat Genet 43:329-32. 2011
    ..New candidate genes include STAT4, DENND1B, CD80, IL7R, CXCR5, TNFRSF1A, CLEC16A and NFKB1. This study has considerably expanded our knowledge of the genetic architecture of PBC...
  50. pmc Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis
    Núria Tarrats
    IDIBAPS, Liver Unit Hospital Clínic, CIBERehd, Barcelona, Spain
    Hepatology 54:319-27. 2011
    ..Using HSCs from wild-type, TNF-receptor-1 (TNFR1) knockout, TNF-receptor-2 (TNFR2) knockout, or TNFR1/R2 double-knockout (TNFR-DKO) mice, we show that loss of both ..
  51. pmc De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF
    A L Mahul-Mellier
    Imperial College London, Experimental Medicine and Toxicology, Hammersmith Campus, Du Cane Road, Burlington Danes Building, London W12 0NN, UK
    Cell Death Differ 19:891-9. 2012
    Components of the TNFR1 complex are subject to dynamic ubiquitination that impacts on their effects as signalling factors...
  52. ncbi Evidence of genetic association between TNFRSF1A encoding the p55 tumour necrosis factor receptor, and ankylosing spondylitis in UK Caucasians
    T Karaderi
    National Institute for Health Research Oxford Musculoskeletal Biomedical Research Unit, Botnar Research Centre, Oxford, UK
    Clin Exp Rheumatol 30:110-3. 2012
    ..To replicate the possible genetic association between ankylosing spondylitis (AS) and TNFRSF1A...
  53. pmc The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
    Jixi Li
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Cell 150:339-50. 2012
    ..The current study provides insight into the structural changes that occur when RIP kinases are triggered to execute different signaling outcomes and expands the realm of amyloids to complex formation and signaling...
  54. pmc NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 7:e41238. 2012
    TNF can trigger two opposing responses: cell survival and cell death. TNFR1 activates caspases that orchestrate apoptosis but some cell types switch to a necrotic death when treated with caspase inhibitors...
  55. doi Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease
    C Steenholdt
    Department of Gastroenterology, Herlev Hospital, Denmark
    Aliment Pharmacol Ther 36:650-9. 2012
    ..Single nucleotide polymorphisms (SNPs) in TNF receptor superfamily (TNFRSF) 1A and 1B, and Fas ligand (FASLG) genes, have been associated with responsiveness to infliximab (IFX) in Crohn's disease...
  56. doi Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS)
    Tiziana Bachetti
    Laboratory of Molecular Genetics, Giannina Gaslini Institute, Genoa, Italy
    Ann Rheum Dis 72:1044-52. 2013
    ..syndrome (TRAPS) is caused by TNFRSF1A mutations, known to induce intracellular retention of the TNFα receptor 1 (TNFR1) protein, defective TNFα-induced apoptosis, and production of reactive oxygen species...
  57. pmc Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor
    Y Nophar
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 9:3269-78. 1990
    ....
  58. doi TNFRSF1A coding variants in multiple sclerosis
    An Goris
    Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 bus 1022, 3000 Leuven, Belgium
    J Neuroimmunol 235:110-2. 2011
    ..26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed...
  59. doi Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis
    Seungseob Kim
    National Institute of Health Sciences, Tokyo Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    Cancer Sci 101:2425-9. 2010
    ..These results indicate an important role of RIP1 in apoptosis induced by combined treatment with TNFα and MeBS, suggesting that MeBS sensitizes cancer cells to apoptosis by modulating RIP1 ubiquitylation and distribution...
  60. ncbi Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation
    D W Banner
    F Hoffmann La Roche Limited, Pharmaceutical Research New Technologies, Basel, Switzerland
    Cell 73:431-45. 1993
    ..The novel fold of the TNF receptor structure is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole...
  61. ncbi A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
    F K Chan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 288:2351-4. 2000
    ..Thus, TNFRs and related receptors appear to function as preformed complexes rather than as individual receptor subunits that oligomerize after ligand binding...
  62. pmc Reduced tumor necrosis factor signaling in primary human fibroblasts containing a tumor necrosis factor receptor superfamily 1A mutant
    Stefan Siebert
    Section of Infection and Immunity, Wales College of Medicine, Cardiff University, Cardiff, UK
    Arthritis Rheum 52:1287-92. 2005
    ....
  63. ncbi Approach to genetic analysis in the diagnosis of hereditary autoinflammatory syndromes
    A Simon
    Division of General Internal Medicine, 541, Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Rheumatology (Oxford) 45:269-73. 2006
    ....
  64. pmc The TNFRSF1A R92Q mutation is frequent in rheumatoid arthritis but shows no evidence for association or linkage with the disease
    Philippe Dieude
    Service de Rhumatologie, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France
    Ann Rheum Dis 66:1113-5. 2007
    ..A recent study suggested that the R92Q mutation was associated with polyarthritis. We aimed to search for this and other TNFRSF1A mutations in rheumatoid arthritis (RA), and to test for linkage...
  65. pmc The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis
    Dieter E Jenne
    Ann Rheum Dis 66:1266-7. 2007
  66. pmc Linkage of familial Hibernian fever to chromosome 12p13
    M F McDermott
    Medical Unit, St Bartholomew s and The Royal London Hospital School of Medicine and Dentistry, Whitechapel, London, UK
    Am J Hum Genet 62:1446-51. 1998
    ....
  67. pmc The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Spain
    EMBO J 18:3044-53. 1999
    ..Together, these results demonstrate that the interaction of p62 with RIP serves to link the atypical PKCs to the activation of NF-kappaB by the TNFalpha signaling pathway...
  68. ncbi Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians
    A Barton
    University of Manchester, UK
    Arthritis Rheum 44:61-5. 2001
    ..The present study was undertaken to investigate association of polymorphisms of TNFRI and TNFRII with RA in subjects in the UK...
  69. ncbi Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes
    Ebun Aganna
    Barts and London, Queen Mary s School of Medicine and Dentistry, London, UK
    Arthritis Rheum 48:2632-44. 2003
    ..To investigate the prevalence of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among outpatients presenting with recurrent fevers and clinical features consistent with TRAPS...
  70. ncbi Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC Studies
    Odette Poirier
    INSERM U525, Epidemiologic and Molecular Genetics of Cardiovascular Diseases, Paris, France
    Eur J Hum Genet 12:213-9. 2004
    ..70 (0.09) vs 0.67 (0.13), P=0.02). No significant association of the 92Q allele was found with BI in the GENIC Study. Overall, these results may suggest that carriers of the 92Q allele may be at increased risk of atherosclerosis...
  71. ncbi Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenot
    Silvia Stojanov
    Department of Infectious Diseases Immunology, Children s Hospital, University of Munich, Munich, Germany
    Arthritis Rheum 50:1951-8. 2004
    ....
  72. ncbi Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis
    Laurent Spahr
    Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland
    J Hepatol 41:229-34. 2004
    ..In patients with AH, we determined the prognostic value of TNF alpha, sTNF-R1, and lipopolysaccharide binding protein (LBP) and CD14, both involved in endotoxemia-associated inflammation...
  73. ncbi Protein and gene expression of tumour necrosis factor receptors I and II and their promoter gene polymorphisms in Alzheimer's disease
    Doris Culpan
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Sciences at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    Exp Gerontol 42:538-44. 2007
    ..Our findings suggest that TNF-RI and -RII promoter gene polymorphisms and variations in protein and gene expression of these receptors are unlikely to play a major role in the development of AD...
  74. doi Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians
    Reeshu Gupta
    Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India
    Oral Oncol 44:455-63. 2008
    ..We assessed SNPs in TNF-alpha(-308, -238) and TNF receptor 1 (TNFR1; -609) promoters by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and at four ..
  75. doi Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients
    Belinda Nedjai
    Centre for Diabetes, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, UK
    Cell Immunol 268:55-9. 2011
    ..condition caused by mutations in the TNFRSF1A gene which encodes the tumor necrosis factor (TNF) receptor, TNFR1. We investigated the effect of three high penetrance and three low penetrance TNFRSF1A mutations upon NF-κB ..
  76. pmc The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail
    Helen Storey
    Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, U K
    Biochem J 366:15-22. 2002
    ..We have shown by immunofluorescence and immunoelectron microscopy that the p55 tumour necrosis factor receptor, TNFR1, is principally localized to the trans-Golgi network in the human breast carcinoma cell line, MCF7...
  77. ncbi Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus
    Jose Manuel Fernandez-Real
    Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona, 17001 Girona, Spain
    Am J Physiol Endocrinol Metab 282:E952-9. 2002
    ..00001). The TNF-alpha receptor 1 (TNFR1) density in peripheral blood monocytes was similar in DM-2 patients and in nondiabetic subjects...
  78. ncbi Single-nucleotide polymorphisms in tumor necrosis factor receptor genes: definition of novel haplotypes and racial/ethnic differences
    S Louis Bridges
    University of Alabama at Birmingham
    Arthritis Rheum 46:2045-50. 2002
    ..To characterize allele frequencies of known single-nucleotide polymorphisms (SNPs) in tumor necrosis factor receptor (TNFR) genes in African Americans with rheumatoid arthritis (RA), healthy African Americans, and healthy Caucasians...
  79. ncbi No association of polymorphisms in the tumor necrosis factor receptor I and receptor II genes with disease severity in rheumatoid arthritis
    John R Glossop
    Staffordshire Rheumatology Centre, The Haywood, Stoke on Trent, Staffordshire, England, UK
    J Rheumatol 30:1406-9. 2003
    ..We investigated whether this particular SNP, and also one at position +36 in exon 1 of the TNF receptor I (TNFRSF1A) gene, are associated with disease severity...
  80. ncbi A TNFR1 genotype with a protective role in familial rheumatoid arthritis
    Philippe Dieude
    GenHotel, Evry Genopole, France
    Arthritis Rheum 50:413-9. 2004
    ..in rheumatoid arthritis (RA) have suggested that the tumor necrosis factor receptor I (TNFRI) and TNFRII loci (TNFR1 and TNFR2) are susceptibility loci. A TNFR2 polymorphism was found to be associated with familial RA...
  81. ncbi Increased hypothalamic expression of the p75 tumor necrosis factor receptor in New Zealand obese mice
    N M Rizk
    Physiology Department, Mansoura Faculty of Medicine, Mansoura University, Egypt
    Horm Metab Res 33:520-4. 2001
    ..TNF-alpha and TNF receptor 1 (p55) expression in hypothalamic tissue was similar in obese and lean animals...
  82. ncbi Effect of blocking TNF on IL-6 levels and metastasis in a B16-BL6 melanoma/mouse model
    S Cubillos
    Laboratorio de Fisiopatologia, Instituto Venezolano de Investigaciones Cientificas (IVIC, Caracas, Venezuela
    Anticancer Res 17:2207-11. 1997
    ..Serum IL-6 levels were increased in inoculated animals. Injection of a hybrid molecule (p55-sf2) composed of the human p55 TNF receptor extracellular domain coupled to a human constant region backbone, ..
  83. ncbi Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
    W H Kim
    Section on Liver Biology, Laboratory of Physiologic Studies, NIAAA, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2551-3. 2001
    ..HCV core protein-mediated activation of NF-kappaB is abolished completely in tumor necrosis factor a receptor 1 (TNFR1) (-/-) hepatocytes...
  84. ncbi TNF-alpha blockade by a dimeric TNF type I receptor molecule selectively inhibits adaptive immune responses
    D B Colagiovanni
    Pharmacology Department, Amgen, Inc, Thousand Oaks, CA 91320, USA
    Immunopharmacol Immunotoxicol 22:627-51. 2000
    ..receptors might alter immune system function, assays were assessed in rodents treated with a dimeric form of the p55 TNF-RI, Tumor Necrosis Factor-binding protein (TNFbp)...
  85. ncbi Correlation of the expression of nuclear factor-kappa B, tumor necrosis factor receptor type 1 (TNFR 1) and c-Myc with the clinical course in the treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2)
    M Yamamoto
    Department of Neurosurgery, Fukuoka University School of Medicine, Japan
    Anticancer Res 20:611-8. 2000
    ..We also investigated the expression of nuclear factor-kappa B (NF-kappa B), tumor necrosis factor receptor type 1 (TNFR1), and c-Myc in human astrocytoma tissues in vivo in patients treated with TNF-SAM2 by RT-..
  86. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
    ..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells...
  87. pmc The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart
    Jana S Burchfield
    Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Heart Fail 3:157-64. 2010
    Activation of both type 1 and type 2 tumor necrosis factor (TNF) receptors (TNFR1 and TNFR2) confers cytoprotection in cardiac myocytes...
  88. ncbi Distribution of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus infected trigeminal ganglia in the mouse
    E T Cunningham
    The Francis I Proctor Foundation, UCSF, Medical Center, San Francisco, CA 94122 0944, USA
    Brain Res 758:99-106. 1997
    to investigate the distribution of p55 and p75 tumor necrosis factor (TNF) receptor mRNA in normal murine trigeminal ganglia, and in murine trigeminal ganglia acutely infected with McKrae strain herpes simplex virus (HSV).
  89. ncbi Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease
    K Bachmaier
    Amgen Institute, Ontario Cancer Institute, Canada
    Circulation 95:655-61. 1997
    ..is involved in the pathogenesis of myocarditis and can bind to either tumor necrosis factor receptor (TNF-R) p55 or TNF-Rp75. However, it is not known which TNF-R mediates the specific functions of TNF in disease...
  90. ncbi Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia
    J M Dopp
    Department of Neurology, UCLA 90095, USA
    J Neuroimmunol 75:104-12. 1997
    ..alpha (LT alpha) induce pleiotropic cellular effects through low-affinity 55 kDa type-1 receptors (TNFR1, CD120a) and high-affinity 75 kDa type-2 receptors (TNFR2, CD120b)...
  91. pmc Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 gene-deficient mice intravenously infected with Mycobacterium avium
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, D 23845 Borstel, Germany
    Infect Immun 67:3571-9. 1999
    ..to compare the development of granulomatous lesions in intravenously infected tumor necrosis factor receptor p55 (TNFRp55) gene-deficient (p55(-/-)) mice to the development of granulomatous lesions in M...
  92. ncbi IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Invest Ophthalmol Vis Sci 40:2583-9. 1999
    ..To determine the role of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the induction of uveitis by a reverse passive Arthus reaction (RPAR)...
  93. doi Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha-converting enzyme-dependent ectodomain shedding
    Tohru Sakimoto
    Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:4618-21. 2009
    ..An involvement of tumor necrosis factor-alpha-converting enzyme (TACE)-dependent ectodomain shedding in the release of soluble tumor necrosis factor receptor 1 (sTNFR1) from corneal epithelium was evaluated...
  94. ncbi Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Germany
    J Immunol 160:3427-36. 1998
    TNF-alpha exerts its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75)...
  95. ncbi Chronic ethanol enhances ectodomain shedding in T cells and monocytes
    Xue Jun Zhao
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Alcohol Clin Exp Res 28:1399-407. 2004
    ..We hypothesized that chronic ethanol through oxidative stress activates TACE-mediated ectodomain shedding of the preformed substrates p75 and p55 TNF receptors in Mono Mac 6 cells and L-selectin in Jurkat T cells.
  96. ncbi Tumor necrosis factor receptor-associated periodic syndrome: a novel syndrome with cutaneous manifestations
    J R Toro
    National Cancer Institute, National Institutes of Health, Bldg 10, Room 12N 238, 10 Center Dr, MSC 1908, Bethesda, MD 20892 1908, USA
    Arch Dermatol 136:1487-94. 2000
    ..To our knowledge, the cutaneous pathologic characteristics of TRAPS have not been described previously...
  97. ncbi A low serum level of soluble tumor necrosis factor receptor p55 predicts response to thalidomide in advanced multiple myeloma
    Anne Tove Brenne
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N 7489 Trondheim, Norway
    Haematologica 89:552-6. 2004
    Thalidomide modulates the production of tumor necrosis factor (TNF-alpha). Soluble TNF receptors, TNFR p55 and TNFR p75, modify TNF-alpha activity...
  98. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..It is generally believed that TNF-α exerts its effects primarily via TNF receptor subtype-1 (TNFR1). We investigated the distinct roles of TNFR1 and TNFR2 in spinal cord synaptic transmission and inflammatory pain...
  99. pmc TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia
    Megan L Kelly
    The Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Shock 33:602-7. 2010
    ..Genetic modification of MSCs is an appealing method to enhance MSC paracrine action. Ablation of TNF receptor 1 (TNFR1), but not TNFR2, increases MSC growth factor production...
  100. doi Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain
    C Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuroscience 169:463-74. 2010
    ..Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood...
  101. ncbi Expression and regulation of Fas antigen and tumor necrosis factor receptor type I in hen granulosa cells
    J T Bridgham
    Department of Biological Sciences, The University of Notre Dame, Notre Dame, IN 46556, USA
    Biol Reprod 65:733-9. 2001
    ..ovary; however, nothing is currently known regarding expression of either Fas or the related tumor necrosis factor receptor type 1 (TNFR1), in avian species...

Research Grants63

  1. Astar Winoto; Fiscal Year: 2016
    ..Successful completion of these aims will greatly enhance our understanding of the host- pathogen interaction and the physiological role of necroptosis. ! ! ! ..
  2. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..reperfusion and ventricular remodeling;their actions are regulated by soluble Type I/Type II TNF receptor (TNFR1/TNFR2), IL-1 receptor antagonist (IL-1ra), and IL-18 binding protein (IL-18bp), respectively...
  3. DOUGLAS LOWELL MANN; Fiscal Year: 2016
    ..previously shown that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  4. Steven L Gonias; Fiscal Year: 2014
    ..levels of other receptors, including the urokinase receptor (uPAR) and tumor necrosis factor receptor-1 (TNFR1)...
  5. Clayton E Mathews; Fiscal Year: 2015
    ..cells and primary islets resist destruction mediated by members of the Tumor Necrosis Factor Receptor family, TNFR1 and Fas...
  6. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
    ..mt-Nd2a encoding beta cells resist destruction mediated by members of the Tumor Necrosis Factor Receptor family, TNFR1 and Fas. Aim 2 will extend the studies to determine the mechanisms utilized by NIT-4 cells to avert lysis by CTL...
  7. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..have shown that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  8. TRADD as a Regulator of Cytokine Signaling in Glia
    ETTY BENVENISTE; Fiscal Year: 2009
    ..Our studies will provide a comprehensive assessment of TRADD function in cytokine signaling, thereby advancing our understanding of this novel signaling pathway in the context of macrophage/microglial activation and neuroinflammation. ..
  9. Respiratory Muscle Weakness in Chronic Inflammation
    Francisco H Andrade; Fiscal Year: 2013
    ..To evaluate sphingolipid signaling as an early post-receptor mechanism by which TNF/TNFR1 stimulates oxidant activity and weakness...
  10. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..Our preliminary data suggest that transgene-mediated p55 soluble tumor necrosis factor receptor (p55sTNFR) or interleukin 10 reduces pain-related behavior and downregulates ..
  11. Steven D Crowley; Fiscal Year: 2015
    ..Mice doubly deficient for the IL-1 receptor (IL-1R) and TNF-receptor 1 (TNFR1) are unable to mount an M1 immune response (M1 KO)...
  12. Suzanne Gaudet; Fiscal Year: 2016
    ..Although TNF receptor 1 (TNFR1) expression is ubiquitous, some cells respond to TNF by differentiating and proliferating, while others commit to ..
  13. Jamie L Renbarger; Fiscal Year: 2016
    ..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
  14. Guy S Salvesen; Fiscal Year: 2016
    ..with Deubiquitinase CYLD to modulate K63 ubiquitination of Rip1, thereby dictating the assembly of TNFR1 signaling complexes that either promote or suppress TNF?-induced apoptosis;and (4) Investigating the mechanisms by ..
  15. MOHAMED HASSAN FARAH; Fiscal Year: 2016
    ..The two proposed substrates are the amyloid precursor protein (APP) in axons and tumor necrosis factor receptor 1 (TNFR1) on macrophages, which infiltrate injured nerves and clear the inhibitory myelin debris...
  16. Cytokine Driven Mechanisms of Vein Graft Failure
    C Ozaki; Fiscal Year: 2009
    ..by way of low wall shear induced pro-inflammatory cytokine driven mechanisms (soluble TNF-a signaling via the p55 receptor, leading to enhanced leukocyte mediated inflammation, and increased cell proliferation)...
  17. Lung radioprotection by inhibition of TNF-alpha and TGF-beta1
    Ming Zhang; Fiscal Year: 2012
    ..Reduction of lung TNF receptor 1 (TNFR1) by antisense oligonucleotide (ASO) or by genetic knock-out in mice is radioprotective by decreasing lung ..
  18. TNF-alpha Underlies Glomerular Aging in B6 Females
    Feng Zheng; Fiscal Year: 2010
    ..Since B6females lacking TNF receptor 1 (TNFR1) are largely protected from glomerular aging, we postulate that increased TNF-a in aging contributes significantly ..
  19. TNF SIGNALING IN THE ABSENCE OF FUNCTIONAL TNF RECEPTORS.
    EDOUARD M CANTIN; Fiscal Year: 2012
    ..In further studies, we showed that B6 mice genetically deleted for either or both of the known TNF receptors TNFR1 or p55 and TNFR2, or p75 were resistant to fatal HSV infection...
  20. Adrian T Ting; Fiscal Year: 2016
    Abstract TNF binding to its receptor TNFR1 triggers cell survival or cell death but the mechanisms that determine which of these two divergent responses is triggered remain to be fully elucidated...
  21. BTK SIGNALING IN B CELL SURVIVAL BY BAFF-R
    Wasif N Khan; Fiscal Year: 2011
    ..The proposed research will illuminate novel mechanisms by which Btk regulates B cell survival critical for normal B cell survival in the healthy immune system as well as B cell autoimmune and immunodeficiency diseases. ..
  22. ASHLESH KRISHNA MURTHY; Fiscal Year: 2016
    ..TNF-a induces pleotrophic effects including apoptosis via two main receptors, TNF receptor 1 (TNFR1) and TNFR2, which have been shown to complement or oppose the effects of each other in different infection models...
  23. TNF receptor-2 signaling in arteriogenesis/angiogenesis
    Wang Min; Fiscal Year: 2010
    ..by applicant): There are two distinct TNF-specific plasma membrane-localized receptors, type I 55 kDa TNFR (TNFR1) and type II 75 kDa TNFR (TNFR2)...
  24. Redox Mechanisms of Ischemia Reperfusion Injury in the Liver
    John F Engelhardt; Fiscal Year: 2013
    ..Aim 2 will investigate the molecular mechanisms by which endosomal Nox controls TNFR1 activation of NF[unreadable]B, using subcellular fractionation assays and Nox-deficient model systems...
  25. Jeffrey D Hasday; Fiscal Year: 2016
    ..g. TNF Receptor- 1/TNFR1 or fas) accelerates assembly of the death inducing signaling complexes, augments downstream pro-apoptotic pathways,..
  26. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2004
    ..Impaired lymphocyte generation was largely rescued in the combined absence of Re1A and TNF receptor 1 (TNFR1), indicating a key function of Re1A may be to prevent TNFR1-induced killing of developing lymphocytes...
  27. The Function of cFLIP in B Lymphocytes
    Jianke Zhang; Fiscal Year: 2009
    ..The results will facilitate the development of effective preventive and therapeutic approaches. ..
  28. IN VIVO EFFECTS OF IL 2--ROLE OF TNF AND TNF R FAMILIES
    James Mier; Fiscal Year: 1999
    ..However, like the p55 TNF receptor, CD40 engagement has been shown to elicit adhesion molecule expression in these cells, thus raising ..
  29. Sex differences in TNFR2 signaling mechanisms following acute surgical ischemia
    Brent Weil; Fiscal Year: 2009
    ..that females exhibit enhanced protection from I/R due to an inherent resistance in detrimental TNF receptor 1 (TNFR1) signaling (2)...
  30. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
    ..induces multiple physiological effects through distinct signaling cascades associated with TNF receptor-type I (TNFR1) and -type II (TNFR2)...
  31. D Brent Polk; Fiscal Year: 2016
    ..This project is focused on understanding the roles played by tumor necrosis factor (TNF) and its receptors (TNFR1 &TNFR2) in coordinating proliferation and apoptosis during intestinal epithelial injury and inflammation...
  32. Chuanju Liu; Fiscal Year: 2015
    ..In a global screen for the binding proteins of progranulin (PGRN) growth factor, we found that PGRN bound to TNFR1 and TNFR2...
  33. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ..of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
  34. Development of small molecule inhibitors the TNF-alpha/TNF-R55 interaction
    Jessica M Davis; Fiscal Year: 2010
    ..This research proposes to use small, orally available therapeutics that have been designed using the mechanism of current therapies for Crohn's disease. ..
  35. Debra L Laskin; Fiscal Year: 2016
    ..The major receptor mediating the reparative actions of TNF-( is TNFR1 (p55), which is localized in caveolin-1 (Cav-1)-containing plasma membrane lipid rafts, or caveolae...
  36. CONTROL OF TNF SIGNALING BY NFKB
    ALBERT BALDWIN JR; Fiscal Year: 2003
    ..The effects of TNFalpha are mediated by two distinct cell surface receptors, p55 TNF-R1 and p75 TNF-R2, that are expressed on almost all cells...
  37. LeBris S Quinn; Fiscal Year: 2014
    ..The effects of IL-15/sIL-15R1 complex variants on TNFR1- mediated TNF-1 signaling in skeletal myogenic and adipogenic cultures will be determined as well...
  38. John H Richburg; Fiscal Year: 2016
    ..via the action of distinct metalloproteinase (MP) enzymes, after MEHP-treatment and that sTNF-? may act upon TNFR1 on Sertoli cells to stimulate an increase in their expression of FasL...
  39. ELENA LEVITSKAIA; Fiscal Year: 2014
    ..Characterization of TNF function in neuroblastoma will prompt investigations on the role of this cytokine in the pathogenesis of other tumors. ..
  40. Macrophages and Inflammatory Mediators in Silica-Induced Carcinogenesis
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..The major receptor mediating the mitogenic actions of TNFa is TNFR1 (p55), which is localized in caveolin-1 (Cav-1)-containing plasma membrane lipid rafts, or caveolae...
  41. OPTICAL IMAGING OF MESENCHYMAL STEM CELL INTERACTIONS WITH LUNG MICROVESSELS
    Jahar Bhattacharya; Fiscal Year: 2013
    ..to MSCAEEC mitochondrial transfer (Specific Aim 2);and that beneficial effects accrue from loss of the receptor (TNFR1) for tumor necrosis factor-[unreadable] (TNF[unreadable]) (Specific Aim 2) and lung microvascular barrier ..
  42. LAURA ANN ASHLEY GILLIAM; Fiscal Year: 2014
    ..Mice deficient in tumor necrosis factor-[unreadable] receptor subtype 1 (TNFR1) were protected against the fall in muscle force...
  43. Development of a Biologically-based Nursing Intervention for Cancer Cachexia
    DONNA MCCARTHY BECKETT; Fiscal Year: 2009
    ..activity preserved gastrocnemious (gastroc) muscle mass and reduced muscle expression of TNFa type 1 receptors (TNFR1) in one model of cancer cachexia, but not in another...
  44. TNF alpha Signaling: Effects on AMPA Receptor Location
    ERIC BEATTIE; Fiscal Year: 2007
    ..Specific aim 1 will determine if signaling from one of the two TNF-alpha receptors- TNFR1, TNFR2, or both contribute to increased AMPAR surface localization...
  45. Patrick N Cunningham; Fiscal Year: 2014
    ..indicate that LPS-induced ARF, a model of septic renal dysfunction, depends on the action of TNF on its receptor TNFR1 in the kidney, and is associated with renal endothelial apoptosis, inflammation, and vascular leak both in vivo ..
  46. Aging, Inflammation and Exercise in Chronic Stroke
    Alice S Ryan; Fiscal Year: 2012
    ..levels) and tissue (adipose tissue and skeletal muscle) inflammation (secretion, expression, and cytokine receptor TNFR1, TNFR2, adipoR1, adipoR2 expression) are disturbed in chronic stroke compared to age, sex, BMI, race, and risk-..
  47. Effects of fish oil on inflammation and metabolic syndrome
    Philip A Kern; Fiscal Year: 2012
    ..changes in recruitment of inflammatory receptors, such as toll-like receptor 4 (TLR4) and TNFαReceptor 1 (TNFR1) to membrane rafts. Hypothesis 3...
  48. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..contractility (Aim 3) with inflammation (induced by TNFa) will then be examined, focusing on specific mechanisms (TNFR1, PTRF, MAPK, NF-?B)...
  49. Sanjoy Roychowdhury; Fiscal Year: 2014
    ..We will also use mice deficient in CYP2E1, TNFR1, and TLR4 to determine upstream activators of the RIP3-signaling pathway in response to ethanol feeding...
  50. Junying Yuan; Fiscal Year: 2016
    ..Activation of TNFR1 by TNF[unreadable] has recently been shown to mediate two alternative cell death pathways: caspase-dependent ..
  51. Cynthia A Lemere; Fiscal Year: 2014
    ..C3fl/fl mice from Aim 1 to ubiquitin-promoter driven Cre-Estrogen receptor 2 mice, treat the mice with tamoxifen at P60, and examine synapses, neurons and glia in hippocampus at 4 mo and 12 mo of age...
  52. Selective Delivery of a novel bacterial adjuvant for multipurpose vaccination
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ..Our current data also suggest that induction of these cells is likely to depend on one bacterial protein, the p60 autolysin, a virulence factor of the bacteria, which functions to digest peptidoglycan (PGN) cell walls...
  53. CTL EFFECTOR MECHANISMS IN ADENOVIRAL HEPATITIS
    DWAIN LOUIS THIELE; Fiscal Year: 2010
    ..from the liver is mediated predominately by alternative CTL effector mechanisms that utilize Fas/FasL, TNF/TNFR1 and/or other death receptor mediated pathways...
  54. DOROTHY ANNE CROSS; Fiscal Year: 2016
    ..Recent work from his laboratory has found that TNFR1 responses of astrocytes are key in promoting infiltration of the parenchyma which is in turn critical for EAE ..
  55. Pathway analysis of tuberculosis pathogenesis
    CATHERINE MARIE STEIN; Fiscal Year: 2013
    ..We have shown that the TNFR1, IL10, and IFNGR1 genes are associated with TB but not resistance to Mtb infection...
  56. Richard P Kraig; Fiscal Year: 2016
    ..measure innate cytokines (IL-1alpha, IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-10), their receptors (IL-1R1, TNFR1, IL-6Ralpha/gp130, IFNgammaR, IL-10R), and related downstream phosphoprotein (kinases (ERK1/2, P38MAPK, JNK) and ..
  57. Caroline A Genco; Fiscal Year: 2016
    ..Successful undertaking of the proposed studies has the potential to identify and validate novel therapeutic interventions that target pathogen evasion mechanisms associated with chronic infection and the resulting inflammatory sequelae. ..
  58. Endothelia mechanisms of leukocyte accumulation in glomerulonephritis
    Tanya N Mayadas; Fiscal Year: 2010
    ..The biological activities of TNF are mediated by two functionally distinct TNFRs, TNFR1 and TNFR2. We have shown that TNFR2 is critical for GN...
  59. David H Broide; Fiscal Year: 2016
    ..An lOFM Core is also proposed as requested by the RFA. ..
  60. Exploring the consequences of the TNFRSF1A susceptibility allele for MS
    Philip L De Jager; Fiscal Year: 2011
    ....
  61. Sandra M Garraway; Fiscal Year: 2014
    ..the role TNFalpha signaling plays in the induction of enhanced pain behaviors following SCI, by administering a TNFR1 blocker...
  62. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..P41-RR00954) and also serves as a core MS laboratory for the WU Diabetes Research and Training Center (DRTC, P60-DK20579) and the WU Clinical Nutrition Research Unit (CNRU, P30-DK56341) that are supported by NIDDK...
  63. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..appreciation that TNF itself may have beneficial or detrimental effects depending on which of its receptors (TNFR1 or TNFR2) is activated...

Patents1

  1. Tumour necrosis factor - alpha binding protein
    Patent Number: GB2246569-A; Date:1992-02-05