TNF-alpha

Summary

Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human

Top Publications

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
  2. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
  3. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
  4. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
  5. pmc Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    Bertrand Boisson
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York, USA
    Nat Immunol 13:1178-86. 2012
  6. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
  7. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
  8. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
  9. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
  10. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005

Detail Information

Publications469 found, 100 shown here

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  2. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
    ..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP...
  3. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1 (TNFR1)...
  4. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    ..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
  5. pmc Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    Bertrand Boisson
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York, USA
    Nat Immunol 13:1178-86. 2012
    ..These data suggest that LUBAC regulates NF-κB-dependent IL-1β responses differently in different cell types...
  6. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  7. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
    To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases.
  8. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
    ..However, the effects upon endothelial cells and the mechanisms involved are not fully understood. We assessed the hypothesis that GLP-1 has protective effects against inflammation and oxidative stress on human endothelial cells...
  9. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
    ..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation...
  10. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005
    ..to assess the association between genetic polymorphisms in interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha (TNFalpha), which are involved in H.pylori infection, and risk of gastric cancer...
  11. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
    ....
  12. doi TNF-alpha gene polymorphism and TNF-alpha levels in obese Asian Indians with obstructive sleep apnea
    Bharat Bhushan
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Respir Med 103:386-92. 2009
    Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA...
  13. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
    ....
  14. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe ..
  15. pmc Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
    Sinead M Flannery
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 286:23688-97. 2011
    ..Collectively, these data demonstrate for the first time an essential role for IRAK-2 in primary human cells for both transcriptional and post-transcriptional TLR responses...
  16. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
    ..It is possible that OGG1 and p53 and TNF-α proteins together or separately may be involved in pathogenesis of AD by repair of oxidative DNA damage and/or apoptosis...
  17. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  18. ncbi Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    S Muller
    German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
    Diabetologia 45:805-12. 2002
    ..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance...
  19. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
    ..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells...
  20. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    ..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course...
  21. pmc TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis
    Youde Jiang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Cell Signal 24:1086-92. 2012
    ..Resolution of the hyperglycemia-induced TNFα levels in retinal endothelial cells may prevent apoptosis through disinhibition of insulin receptor signaling...
  22. ncbi c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003
    The signaling pathway involved in tumor necrosis factor-alpha (TNF-alpha)-induced intercellular adhesion molecule-1 (ICAM-1) expression was further studied in human A549 epithelial cells...
  23. ncbi Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea
    Ja Young Lee
    Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong gu, Seoul 134 701, South Korea
    Cancer Lett 225:207-14. 2005
    ..pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea...
  24. pmc Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R8. 2009
    ..TNFalpha activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFalpha-regulated gene expression in chondrocytes is unknown...
  25. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-..
  26. doi HO-1 underlies resistance of AML cells to TNF-induced apoptosis
    Stuart A Rushworth
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK
    Blood 111:3793-801. 2008
    In human monocytes, tumor necrosis factor (TNF) induces a proinflammatory response. In NF-kappaB-inhibited monocytes, TNF stimulates cell death/apoptosis...
  27. pmc Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
    Janina Suchy
    International Hereditary Cancer Center Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    BMC Cancer 8:112. 2008
    ..This fact suggests that genetic variations in inflammatory response genes may act as CRC disease risk modifiers...
  28. pmc Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes
    Monika A Niewczas
    Research Division of Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 4:62-70. 2009
    ..The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria...
  29. ncbi Frequency of distribution of inflammatory cytokines IL-1, IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea
    K Popko
    Department of Laboratory Medicine and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 59:607-14. 2008
    ..The study revealed a significant correlation between polymorphism located in the promoter region of inflammatory cytokine genes and obesity-related OSAS...
  30. pmc Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    Paul D Upton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    J Biol Chem 284:15794-804. 2009
    ..This differential signaling may contribute to the contrasting pathologies of hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension...
  31. doi Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia
    Migraci Tosun
    Department of Obstetrics and Gynecology, Ondokuz Mayis University, Samsun, Turkey
    J Matern Fetal Neonatal Med 23:880-6. 2010
    ..to investigate the relationship of maternal and umbilical cord interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) serum levels with the existence and severity of preeclampsia...
  32. doi The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis
    Yu Yang
    Department of Oncology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    J Cancer Res Clin Oncol 137:947-52. 2011
    ..The aim of this study was to determine more precise estimations for the relationship between TNF-α, IL-1B, and IL-10 polymorphisms and the risk for HCC by meta-analysis...
  33. doi Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts
    Hiroyuki Eda
    Discovery Biology, Global Research and Development, St Louis Laboratories, Pfizer Inc, 700 Chesterfield Parkway West, mail zone AA3C, Chesterfield, MO 63017, USA
    Rheumatol Int 31:1525-30. 2011
    ..Among four inflammatory cytokines [(IL-1β, IL-6, IL-17, and tumor necrosis factor-α (TNF-α)], IL-34 mRNA expression level was dramatically induced by IL-1β (17-fold) and TNF-α (74-fold)..
  34. pmc Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation
    Ananthamurthy Nagabhushana
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    PLoS ONE 6:e17477. 2011
    ..These results suggest that optineurin regulates NF-κB activation by mediating interaction of CYLD with ubiquitinated RIP thus facilitating deubiquitination of RIP...
  35. pmc TNFα enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands
    Prakash Radhakrishnan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Biophys Res Commun 409:436-41. 2011
    ..These results support the hypothesis that inflammation contributes to cancer metastasis...
  36. doi Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder
    Pichili Vijaya Bhaskar Reddy
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Neurochem Res 37:1697-706. 2012
    ..of NOX2, a subunit of NADPH oxidase, and also an upregulated expression of nuclear factor kappa B, tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9)...
  37. doi META060 attenuates TNF-α-activated inflammation, endothelial-monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes
    Anuradha Desai
    Metagenics, Inc, Gig Harbor, WA 98332, USA
    Atherosclerosis 223:130-6. 2012
    ..A modified hop extract, META060, was identified as an inhibitor of inflammatory mediators in human rheumatoid arthritis synovial fibroblasts...
  38. doi Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1ß toxicity through AdipoR1
    Ersilia Nigro
    CEINGE Biotecnologie Avanzate scarl, Naples, Italy
    Int J Biochem Cell Biol 45:1145-53. 2013
    ..Further studies are needed to fully elucidate the Acrp30 lung effects in vivo but our results confirm this adipokine as a promising therapeutic target in lung diseases...
  39. pmc TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures
    Nadine Tarantino
    Unité de Signalisation Moléculaire et Activation Cellulaire and 2 Laboratoire Trafic Membranaire et Division Cellulaire, Institut Pasteur, Centre National de la Recherche Scientifique URA 2582, Paris 75015, France
    J Cell Biol 204:231-45. 2014
    ..Thus, different mechanisms are involved in the recruitment of NEMO into supramolecular complexes, which appear to be essential for NF-κB activation. ..
  40. doi Systemic cytokine response in patients with community-acquired pneumonia
    H Endeman
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Eur Respir J 37:1431-8. 2011
    ..IL-1RA, IL-6, IL-8 and IL-10 are acute phase proteins, independent of genotype. Their levels are influenced by the nature of the causative microorganism and the start of corticosteroids therapy...
  41. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor alpha (TNF-alpha) using PCR-based genotyping assays...
  42. ncbi The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Hypertens 18:1271-5. 2005
    b>Tumor necrosis factor-alpha (TNF-alpha) has been associated with obesity, obesity-related hypertension, and metabolic syndrome...
  43. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
    ..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO...
  44. ncbi Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation
    Mohamed Hassan
    Department of Dermatology, Faculty of Medicine, University of Duesseldorf, Mooren Strasse 5, 40225 Duesseldorf, Germany
    Cell Signal 19:301-11. 2007
    ..patients is associated with the production of serum and interhepatic inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha)...
  45. pmc Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles
    Danielle B Peterson
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Proteomics 8:2430-46. 2008
    ..umbilical vein endothelial cells by stimulation with plasminogen activator inhibitor type 1 (PAI-1) or tumor necrosis factor-alpha (TNF-alpha) and subjected to proteomic analysis by LC/MS...
  46. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
    ..FDCs produced soluble tumor necrosis factor alpha (TNF-alpha) ex vivo, and the addition of a blocking soluble TNF receptor ablated FDC-mediated HIV ..
  47. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  48. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    ..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes...
  49. pmc Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells
    Mostafa A Gabr
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Orthop Res 29:1-7. 2011
    Interleukin-17 (IL-17) is a cytokine recently shown to be elevated, along with interferon-γ (IFNγ) and tumor necrosis factor (TNFα), in degenerated and herniated intervertebral disc (IVD) tissues, suggesting a role for these cytokines ..
  50. doi TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis
    Ioanna Tsagaraki
    Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
    Cell Tissue Res 342:87-96. 2010
    b>Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine affecting diverse cellular responses...
  51. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    ..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs...
  52. doi Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α
    Rebecca K Studer
    VA Pittsburgh, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 36:593-9. 2011
    ..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function...
  53. doi Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1
    Maria J Smolinska
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford University, London W6 8LH, United Kingdom
    J Immunol 187:6043-51. 2011
    ..These data highlight the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase for the alleviation of excessive inflammation...
  54. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  55. ncbi Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases
    Thorsten Hagemann
    Department of Haematology Oncology, Georg August University, Gottingen, Germany
    Carcinogenesis 25:1543-9. 2004
    ..In summary, we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to TNF-alpha dependent MMP induction in the macrophages...
  56. ncbi Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer
    Chuen Ming Shih
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Lung Cancer 52:15-20. 2006
    Genetic polymorphisms in the promoter region of the tumor necrosis factor-alpha (TNF-alpha) gene are involved in the regulation of expression levels and have been associated with various inflammatory and malignant conditions...
  57. doi Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells
    Hatim Hemeda
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany
    Stem Cells Dev 19:693-706. 2010
    ..Altogether, our data show that properties of MSCs depend on local environmental factors. In particular, we have shown that IFN-gamma and TNF-alpha differentially regulate cytokine expression and migration of MSCs...
  58. ncbi Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:15587-94. 2003
    ..However, the involvement of TLR-4 and MD-2 in this process was ruled out...
  59. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..and cross-talk with insulin, 3T3-L1 adipocytes were cultured for different times with IL-6 and tumor necrosis factor alpha (TNF-alpha)...
  60. doi Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
    Jan Hendrik Egberts
    Division of Molecular Oncology, Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 68:1443-50. 2008
    ..In the present work, we investigated the role of the major proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) in the malignancy of PDAC cells in vitro and in vivo...
  61. doi Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways
    Fabrizio Montecucco
    Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
    Cell Signal 20:557-68. 2008
    ..Although highly speculative, ERK 1/2 p44 may represent a selective target for the pharmacologic manipulation of neutrophil-mediated adverse activities in TNF-alpha-mediated inflammatory states...
  62. pmc S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 283:35375-82. 2008
    ..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling...
  63. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  64. ncbi Autoimmunity and tuberculosis. Opposite association with TNF polymorphism
    Paula A Correa
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
    J Rheumatol 32:219-24. 2005
    To examine the influence of the -308 and -238 single nucleotide polymorphisms (SNP) of tumor necrosis factor-a gene (TNF) on patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjogren's syndrome (SS), ..
  65. ncbi IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma
    Gifone Aguiar Rocha
    Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Int J Cancer 115:678-83. 2005
    ..Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in ..
  66. ncbi TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Bloco 2, 9 andar, CEP 05403 001 São Paulo, Brazil
    Microbes Infect 8:598-603. 2006
    ..We typed the TNFa microsatellite and the -308 TNF promoter polymorphism and then analyzed the survival curves of 42 patients with ..
  67. doi Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naïve monocytes to produce TNF-alpha through cellular cross-talk
    Hang Xie
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Cell Microbiol 10:1453-67. 2008
    ..These results suggest that M. catarrhalis LOS could induce excessive middle ear inflammation through a cellular cross-talk mechanism during OME...
  68. doi Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population
    Silvia Jiménez-Morales
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
    Hum Immunol 70:251-6. 2009
    There is a great deal of evidence that points to the association of the tumor necrosis factor-alpha (TNF-alpha) gene as a common genetic factor in the pathogenesis of diseases that are caused by inflammatory and/or autoimmune etiologies...
  69. pmc Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites
    Stephen J Wort
    Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:24297-305. 2009
    ..synergistic induction of preproET-1 message RNA and release of mature peptide by a combination of tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) in primary human pulmonary artery smooth muscle cells...
  70. pmc Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population
    Muhammad Imran Khan
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 15:2861-7. 2009
    The purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in ..
  71. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
    ..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control...
  72. ncbi Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population
    P Kummee
    Inter Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
    J Viral Hepat 14:841-8. 2007
    ..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection...
  73. ncbi FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
    Mani Alikhani
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:12096-102. 2005
    b>Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory and pro-apoptotic mediator that plays an important role in several normal and disease processes...
  74. doi Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women
    Yael T Joffe
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Cape Town, South Africa
    J Nutr 140:901-7. 2010
    ..This study explored interactions between dietary fat intake and the tumor necrosis factor-alpha (TNFA) -308 G/A polymorphism on obesity, insulin resistance, and serum lipid concentrations in ..
  75. ncbi Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study
    J P Mira
    Intensive Care Unit, Cochin Port Royal University Hospital, Paris, France
    JAMA 282:561-8. 1999
    b>Tumor necrosis factor alpha (TNF-alpha) is believed to be a cytokine central to pathogenesis of septic shock...
  76. pmc Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production
    Nicole J Horwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, United Kingdom
    J Exp Med 197:1603-11. 2003
    Lipopolysaccharide (LPS), a product of Gram-negative bacteria, is potent mediator of tumor necrosis factor (TNF)alpha production by myeloid/macrophage cells...
  77. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  78. ncbi Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways
    Xianghuai Lu
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033, USA
    J Biol Chem 281:6297-306. 2006
    Osteoblast (OB) differentiation is suppressed by tumor necrosis factor-alpha (TNF-alpha), an inflammatory stimulus that is elevated in arthritis and menopause...
  79. ncbi Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes
    Seong Su Nah
    Division of Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    FEBS Lett 581:1928-32. 2007
    ..In conclusion, accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha...
  80. doi Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 35:846-51. 2008
    ....
  81. doi Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma
    Mohammad Reza Razeghinejad
    Department of Ophthalmology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Ophthalmic Res 42:118-24. 2009
    ..Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study.
  82. ncbi Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease
    Maqsood M Elahi
    Department of Human Sciences, Human Genetics Laboratory, Loughborough University, Leicestershire, UK
    Biochim Biophys Acta 1792:163-72. 2009
    b>Tumor necrosis factor-alpha (TNF-alpha) is a potent immunomediator and proinflammatory cytokine that has been implicated in the pathogenesis of a large number of human diseases...
  83. ncbi Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 335:1254-63. 2005
    ..Our data suggest that adiponectin constant presence in the circulation in high levels (in lean subjects) renders macrophages resistant to pro-inflammatory stimuli, including its own...
  84. doi Association of TNF-α polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis
    Qiang Tong
    Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Yangpu District, No 168 Changhai Road, Shanghai 200433, China
    Pharmacogenomics 14:1691-700. 2013
    ..To explore whether TNF-α promoter -308 A/G and -857 C/T polymorphisms have an association with responsiveness to TNF blockers in spondyloarthritis and inflammatory bowel disease...
  85. doi Tumor necrosis factor region polymorphisms are associated with AIDS and with cytomegalovirus retinitis
    Neifi H S Deghaide
    Division of Clinical Immunology, Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    AIDS 23:1641-7. 2009
    The tumor necrosis factor (TNF) gene is located within the highly polymorphic major histocompatibility complex region, exhibiting the -308 GA promoter region polymorphism and six microsatellites (TNFa-f) spanning the region nearby the ..
  86. doi TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients
    M M Silva
    Department of General and Specialized Nursing, College of Nursing of Ribeirão Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    Int J Immunogenet 37:379-85. 2010
    The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS)...
  87. doi Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus
    A Rana
    Department of Immunopathology, Post Graduate Institute of Medical Education and Research, India
    Lupus 21:1105-12. 2012
    ....
  88. doi Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes
    Juan Xue
    Department of Urology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P R China
    Mol Med Rep 8:1755-60. 2013
    b>Tumor necrosis factor (TNF)-α and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) are important in osteoarthritis (OA) cartilage degradation...
  89. ncbi Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease
    Ming Yuh Shiau
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Clin Biochem 40:213-7. 2007
    ....
  90. ncbi Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes
    Roland Schmidt
    Deutsches Herzzentrum und I Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, 80636 München, Germany
    Circ Res 102:302-9. 2008
    ..activation (according to Western blot) in monocytes with increased MMP-9 (zymography), interleukin-6, and tumor necrosis factor-alpha secretion (according to ELISA) by monocytes...
  91. doi Mechanism of TNF-α-induced migration and hepatocyte growth factor production in human mesenchymal stem cells
    Aibin Zhang
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    J Cell Biochem 111:469-75. 2010
    ..b>Tumor necrosis factor-α (TNF-α) plays a central role in induction of proinflammatory signaling and paradoxically activates ..
  92. ncbi Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies
    H Chinoy
    The University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD
    Rheumatology (Oxford) 46:1411-6. 2007
    ..To investigate haplotype tagging single nucleotide polymorphisms (SNPs) in the tumour necrosis factor alpha (TNF-alpha) gene, in UK Caucasian idiopathic inflammatory myopathy (IIM) patients...
  93. ncbi Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..b>Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be ..
  94. pmc Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis
    Le Zhuang
    Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China
    PLoS ONE 8:e68827. 2013
    b>Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk.
  95. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
    ..RIP is also required for necrotic death induced by tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL)...
  96. ncbi Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis
    Jennica Lutz
    Division of Immunology Rheumatology, Children s Memorial Hospital, Department of Pediatrics, Northwestern University Medical School, Children s Memorial Institute for Education and Research, Chicago, Illinois 60614, USA
    Clin Immunol 103:260-3. 2002
    Vascular occlusion is more frequent in children with juvenile dermatomyositis (JDM) who have the TNF alpha-308A allele. One of the potent anti-angiogenic factors is thrombospondin-1 (TSP-1)...
  97. ncbi Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps
    Sonja Pezelj-Ribaric
    Departments of Dental Pathology and Stomatology, Medical School, University of Rijeka, Rijeka, Croatia
    Arch Med Res 33:482-4. 2002
    The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps.
  98. ncbi Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor
    Wei Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 280:19036-44. 2005
    Although both tumor necrosis factor (TNF) and H2O2 induce activation of c-Jun N-terminal kinase (JNK) kinase cascades, it is not known whether they utilize distinct intracellular signaling pathways...
  99. ncbi Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNFalpha in human epidermal keratinocytes (HaCaT)
    Kenji Onda
    Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 351:266-72. 2006
    ..Here, we report that tumor necrosis factor (TNF) alpha reduces GC-induced transactivation of endogenous genes as well as a reporter plasmid which ..
  100. pmc Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum
    Jacob E Friedman
    Department of Pediatrics, University of Colorado Denver, P O Box 6511, MS 8106, Aurora, CO 80045, USA
    Diabetes 57:606-13. 2008
    ..However, the cellular mechanisms underlying this insulin resistance are unknown...
  101. doi Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
    Yoshinori Hiraoka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 370:154-8. 2008
    b>Tumor necrosis factor-alpha (TNF-alpha) is released from cells by proteolytic cleavage of a membrane-anchored precursor. The TNF-alpha-converting enzyme (TACE/ADAM17) is the major sheddase for ectodomain shedding of TNF-alpha...

Research Grants109 found, 100 shown here

  1. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) activate glia to release TNF1...
  2. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..asthmatics to demonstrate systemic inflammation, resulting in increased expression of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-?) and other proinflammatory cytokines and leading to GC insensitivity...
  3. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..and microglia) oppose the analgesic effects of morphine, through the release of proinflammatory cytokines: tumor necrosis factor (TNF), interleukin-1 (IL1) &interleukin-6 (IL6)...
  4. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    ..Prior studies have shown that the cytokines tumor necrosis factor-alpha (TNF) and interleukin-1 (IL-1) sensitize vascular endothelial cells to the cytotoxic action of Stxs ..
  5. Innate Immune Bacterial Recognition and Osteoclastogenesis
    Caroline A Genco; Fiscal Year: 2010
    ..contribute to the acceleration of bone resorption by the production of proinflammatory cytokines including tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, and receptor activator of nuclear factor B ligand (RANKL) (54,94,104)...
  6. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
    ..GCK is also required for these PAMPs to stimulate, in macrophages, stabilization of the mRNA for tumor necrosis factor (TNF), the release of TNF, and the induction of a large number of proinflammatory cytokines/chemokines, ..
  7. CYTOKINES AND INFLAMMATORY BOWEL DISEASE
    Fabio Cominelli; Fiscal Year: 2009
    There is increasing evidence that cytokines, in general, and tumor necrosis factor (TNF), in particular, may play a key role in the pathogenesis of Crohn's disease (CD), one of the known idiopathic inflammatory bowel diseases (IBD)s...
  8. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..Studies from this laboratory have shown that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  9. IL-1?? as a mediator of maternal infection-induced effects on offspring neuroinfl
    Heping Zhou; Fiscal Year: 2010
    ..a major component of Gram-negative bacteria cell wall, attenuated the mRNA expression of cytokines, namely tumor necrosis factor (TNF)-???? interleukin (IL)-1??, and IL-6, and chemokines, namely macrophage inflammatory protein (MIP)-1??..
  10. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Such soluble mediators include tumor necrosis factor (TNF)-??and interleukin (IL)-6, which are produced by Kupffer cells, and hepatocyte growth factor (HGF), ..
  11. HIV-1 regulation by MTb: pathogen and host factor
    Anne Goldfeld; Fiscal Year: 2010
    ..These signals mediate the induction of proinflammatory cytokines, including tumor necrosis factor (TNF) and IL-6...
  12. Macrophages and TLR4 in Ischemic Acute Kidney Injury (AKI)
    JOHN ROBERT HARTONO; Fiscal Year: 2010
    ..applicant): Macrophages play a role in acute renal failure by releasing proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, IL-1, IL-6 which are downstream of the TLR (Toll-like receptor) 4 pathway...
  13. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..synthesis;(3) determine the interaction of mechanical stress with interleukin 1, interleukin 17, and tumor necrosis factor alpha in the production of pro-inflammatory mediators, and (4) determine the interaction between the NO and ..
  14. Targeting host response to DAMP for therapy of Rheumatoid Arthritis
    Dexing Fang; Fiscal Year: 2011
    ..confirm the therapeutic effect of CD24Fc and compare CD24Fc with Enbrel, the clinically used soluble receptor for TNFa. In addition, we will establish an in vitro model to demonstrate the mode of action of the CD24Fc, as detailed in ..
  15. PARP-1 in Juvenile Idiopathic Arthritis-associated IL-10 Promoter Polymorphisms
    Jianguo Liu; Fiscal Year: 2011
    ..production of proinflammatory cytokines and suppresses the effects of proinflammatory cytokines such as tumor necrosis factor-a (TNF-a)...
  16. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
    ..survivors with fatigue have higher levels of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-1), and circulating T lymphocytes compared with survivors without fatigue...
  17. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..NF-kB activation by proinflammatory cytokines such as tumor necrosis factor (TNF) or interleukin-1 (IL-1), and bacterial products such as lipopolysaccharide (LPS) is normally ..
  18. Adenosine Receptors and Atherogenesis
    Katya Ravid; Fiscal Year: 2012
    ..Augmentation of proinflammatory cytokines, such as tumor necrosis factor-[unreadable] (TNF-[unreadable]), is the underlying mechanism for an observed upregulation of leukocyte ..
  19. Stage-specific Impact of TNF-alpha Receptor Signaling in Alzheimer's Disease
    SARA LYNN MONTGOMERY; Fiscal Year: 2012
    ..We have previously shown that the potent pro-inflammatory molecule, tumor necrosis factor-alpha (TNF-alpha), is up-regulated in 3xTg-AD mice at ages preceding the development of hallmark amyloid ..
  20. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..infection with Hc in mice induces apoptosis of CD45+ lung leukocytes;apoptosis is controlled largely by tumor necrosis factor (TNF)-1 and Fas-Fas ligand interaction...
  21. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..b>Tumor necrosis factor (TNF-1), Interleukin-1 (IL-12), and Interleukin-18 (IL-18) are the most potent proinflammatory cytokines ..
  22. Mechanisms of Pulmonary Mast Cell Recruitment and Maturation
    MICHAEL FAGERSTEN GURISH; Fiscal Year: 2012
    ..MCp in the allergen-challenged lung that depends on CD4+ cells and the cytokines interleukin (IL)-9 and tumor necrosis factor alpha (TNFa) although not on Th1 or Th2 cells...
  23. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
    ..to: MCP-1 (monocyte chemotactic protein-1, which can recruit macrophages to adipose tissue), TNF-1 (tumor necrosis factor-1, a pro-inflammatory mediator secreted by macrophages), and IL-8 (interleukin-8, a pro-inflammatory ..
  24. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..key mediators of inflammation, and are known to mediate the effects of pro-inflammatory cytokines such as tumor necrosis factor-? (TNF?) that are of central importance in IBD...
  25. Robert T Means; Fiscal Year: 2014
    ..II acute phase protein, the expression of which is induced by interleukin (IL)-6, and down-regulated by tumor necrosis factor (TNF)...
  26. Mark S Nanes; Fiscal Year: 2014
    ..We previously showed that tumor necrosis factor-1 (TNF), a major inflammatory mediator in arthritis, potently inhibits OB differentiation, suggesting that ..
  27. DOUGLAS LOWELL MANN; Fiscal Year: 2016
    ..We have previously shown that the cytoprotective effects of tumor necrosis factor (TNF) are conveyed by both the type 1 (TNFR1) and type 2 (TNFR2) TNF receptors...
  28. Steven D Crowley; Fiscal Year: 2015
    ..the kidney coupled with enhanced renal expression of the M1 effector cytokines Interleukin-1 (IL-1) and tumor necrosis factor-a (TNF-a)...
  29. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..inflammation is a key aspect of airways disease, and exposure to several inflammatory mediators (such as tumor necrosis factor (TNFa) and interleukin-13 (IL-13)) increase ASM contractility...
  30. Astar Winoto; Fiscal Year: 2016
    ..The Tumor Necrosis Factor Receptor (TNF-R) family of death receptors can trigger apoptosis but also an alternative form of death ..
  31. Andrew H Miller; Fiscal Year: 2014
    ..have been associated with IFN-alpha-induced increases in peripheral blood and/or CSF concentrations of tumor necrosis factor-alpha and interleukin-6 and their soluble receptors as well as chemokines such as monocyte chemoattractant ..
  32. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..Endothelial cells reprogram their transcriptional network in response to cytokine stimulation such as tumor necrosis factor alpha (TNF1), interleukin (IL), lipopolysaccharide (LPS), or interferons (IFNs)...
  33. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..Exploratory aims are to (1) explore the relationships among selected markers of inflammation (tumor necrosis factor alpha [TNF-1], interleukin-6 [IL-6], interleukin-IL1-2 [IL1-2], and C-reactive protein [CRP]), symptoms and ..
  34. Howard C Crawford; Fiscal Year: 2015
    ..In Aim 3, we will use pharmacological inhibition of ADAM17 released cytokines tumor necrosis factor alpha (TNFa) and interleukin 6 receptor (IL6R) to test for their influence on the etiology of pancreatic ..
  35. Suppression of vascular endothelial cell inflammation
    Xiao Feng Yang; Fiscal Year: 2013
    ..endothelial cells (ECs) are targets of proinflammatory cytokines, such as interleukin-1b (IL-1b) and tumor necrosis factor-a (TNF-a)...
  36. Ted A Bateman; Fiscal Year: 2015
    ..from bone-marrow's early inflammatory response to radiation damage) of osteoclasts via the cytokines tumor necrosis factor-alpha (TNFa) and interleukin-1 (IL-1)...
  37. Yajaira Suarez; Fiscal Year: 2016
    ..Cytokines, such as vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) mediate this activation and play fundamental roles in the control of angiogenic and inflammatory ..
  38. Andrew P Lane; Fiscal Year: 2015
    ..b>Tumor necrosis factor alpha (TNF-1) is a prominent cytokine in CRS that also has diverse effects on neurons...
  39. Structural and functional studies of the IkappaB kinase (IKK) complex
    Hao Wu; Fiscal Year: 2013
    ..in response to ligation of many receptors including T-cell receptors, B-cell receptors, members of the tumor necrosis factor (TNF) receptor superfamily and the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) superfamily...
  40. Cun Yu Wang; Fiscal Year: 2016
    ..Multiple pro-inflammatory molecules, including tumor necrosis factor (TNF), interleulin-1 (IL-1), IL-6, IL-8, intercellular adhesion molecule-1, cyclooxygenase-2 (COX-2), ..
  41. VALENTIN ATANASSOV PAVLOV; Fiscal Year: 2014
    ..role of cholinergic activation in the brain in reducing systemic levels of the pro-inflammatory cytokines tumor necrosis factor (TNF) and high mobility group box1 (HMGB1) and improving survival during lethal inflammation...
  42. Andrew H Miller; Fiscal Year: 2014
    ..Infliximab is a monoclonal antibody that targets the inflammatory cytokine, tumor necrosis factor (TNF)-alpha, which has been shown to be reliably elevated in patients with major depression...
  43. Lionel B Ivashkiv; Fiscal Year: 2016
    ..arthritis (RA) is well established and has been validated by successful therapeutic targeting of tumor necrosis factor (TNF)...
  44. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..Generation of nitric oxide and of cytokines such as tumor necrosis factor-alpha and interleukin 1-beta are associated with early progression of APAP hepatotoxicity, and PAR-1 ..
  45. GPCR Kinase-2 in TNFalpha Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Preliminary data demonstrates that tumor necrosis factor- (TNF)-induced NFB signaling, and the consequent inflammatory mediator expression and survival of ..
  46. Joel A Swanson; Fiscal Year: 2016
    ..Activation of macrophages by lipopolysaccharide (LPS) and cytokines such as interferon-? (IFN?) and tumor necrosis factor-[unreadable] (TNF[unreadable]) increases their microbicidal activities but also increases damage to ..
  47. Salah Uddin Ahmed; Fiscal Year: 2016
    ..IL-6 levels are several-fold higher than those of IL-1[unreadable] or tumor necrosis factor (TNF)-[unreadable] in the serum and joints of adjuvant-induced arthritis (AIA) rats, and EGCG ameliorated ..
  48. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..Abnormal cytokine metabolism is a major feature of ALD. Elevated serum concentrations of tumor necrosis factor (TNF) and TNF-inducible proinflammatory cytokines/chemokines, such as IL-8 and IL-18 have been reported in ..
  49. Debra E Lyon; Fiscal Year: 2014
    ..disturbances;pain), inflammatory activation [(levels of C- reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1B), and interleukin 6 (IL- 6)], and epigenetic alterations in 75 women ..
  50. Ajit K Verma; Fiscal Year: 2015
    ..development of squamous cell carcinoma (SCC) via increased expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation ..
  51. Steven D Crowley; Fiscal Year: 2016
    ..into the kidney, and enhanced expression of pro-inflammatory cytokines including interferon-g (IFN-g) and tumor necrosis factor-a (TNF-a)...
  52. LAURA MARIE TONKS RAFFIELD; Fiscal Year: 2015
    ..Our initial focus will be on the C1q and tumor necrosis factor (TNF) superfamily of genes...
  53. The involvement of IL-12 and IL-27 in immunity to Mycobacterium tuberculosis
    CORY MICHAEL ROBINSON; Fiscal Year: 2013
    ..The first aim utilizes molecular approaches to identify important cytokines and test the hypothesis that tumor necrosis factor and IFN-D are indispensable to this mechanism...
  54. Zhongcong Xie; Fiscal Year: 2016
    ..Neuroinflammation includes microglia activation and increases in pro-inflammatory cytokines such as tumor necrosis factor (TNF)-[unreadable], interleukin-6 (IL-6), and IL-1[unreadable] in the brain...
  55. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..of many of the proinflammatory cytokines involved in psoriasis, including interleukin (IL)-6 and tumor necrosis factor (TNF)-1...
  56. BLAINE ANDREW CHRISTIANSEN; Fiscal Year: 2016
    ..In Aim 2 we will assess the ability of treatments that inhibit the inflammatory cytokines tumor necrosis factor-[unreadable] (TNF-[unreadable]), interleukin-1 (IL-1), and interleukin-6 (IL-6) to prevent structural ..
  57. ANDREA G NACKLEY NEELY; Fiscal Year: 2014
    ..We show that COMT inhibition results in increased expression of the proinflammatory cytokines tumor necrosis factor-alpha (TNF1), interleukin-12 (IL-12), and interleukin-6 (IL-6) as well as nitric oxide (NO), and that this ..
  58. Craig J McClain; Fiscal Year: 2016
    ..Both agents have anti-inflammatory activities and downregulate proinflammatory cytokines such as tumor necrosis factor (TNF)...
  59. Mark R Opp; Fiscal Year: 2016
    ..adults is fragmented, and sleep disruption is associated with increased production of cytokines, including tumor necrosis factor (TNF)...
  60. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..In leukocyte-free first trimester decidual cells, we found that the pro-inflammatory cytokines, tumor necrosis factor-a (TNF-1) and interleukin-1 beta (IL-12), profoundly enhanced expression of macrophage-colony stimulating ..
  61. Tomoki Hashimoto; Fiscal Year: 2016
    ..cell population in KitW-sh/W-sh mice by bone marrow-derived mast cells from mice lacking interleukin-6, tumor necrosis factor-alpha, or interferon-gamma...
  62. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..Among these cytokines, tumor necrosis factor (TNF) has received the greatest attention because of its position at the apex of the inflammatory and ..
  63. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..and bioactive androgens);and high levels of pro- inflammatory cytokines (interleukine (IL)-1p, IL-6 &tumor necrosis factor (TNF)-a) during mid-gestation...
  64. Frank B Hu; Fiscal Year: 2016
    ..axis (leptin, soluble leptin receptor (sOB-R), insulin, adiponectin, retinol binding protein 4 [RBP4], tumor necrosis factor receptor 2 [TNF-R2], and interleukin 6 [IL-6]) among 1,000 healthy NHS II participants who provided ..
  65. Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications o
    Gregory F Oxenkrug; Fiscal Year: 2010
    ..IDO activity and production of IFN-gamma (IFNG) (the strongest transcriptional inducer of IDO), and of tumor necrosis factor-alpha (TNF-alpha) that amplifies IFNG-induced IDO expression...
  66. M Kerry O'Banion; Fiscal Year: 2016
    ..AD-related pathogenesis, we further hypothesize that antagonism of a key inflammatory regulator, namely tumor necrosis factor (TNF)-a, will lessen exposure-related pathology...
  67. Interactions among Depressive Symptoms and Genetic Influences on Cardiac Outcomes
    Lorraine Q Frazier; Fiscal Year: 2011
    ..Inflammatory proteins and genes include: Interleukin (IL) 6, C-reactive protein (CRP), Tumor Necrosis Factor Alpha (TNFa), E-Selectin (SELE) and Monocyte Chemoattractant Protein-1 (MCP-1)...
  68. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    ..Levels of the pro-inflammatory cytokine tumor necrosis factor a (TNFa) are elevated during acute KD and levels are highest in children in whom coronary artery aneurysms ..
  69. Stephen P Peters; Fiscal Year: 2015
    ..trial in adults designed to test the hypothesis that severe asthmatics with specific genetic variants in tumor necrosis factor (TNF) receptor genes respond better to anti-TNF than patients without these variants...
  70. Ashraf Gorgey; Fiscal Year: 2016
    ..free fatty acids, serum total and free testosterone and IGF-1), and cytokines (c-reactive protein, tumor necrosis factor alpha and IL-6 as inflammatory biomarkers) after 16 weeks of training+Tp and detraining...
  71. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..P-gp at the brain endothelial cell is inhibited by lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF)...
  72. C Yan Cheng; Fiscal Year: 2016
    ..Recent studies have shown that cytokines (e.g., tumor necrosis factor ?, TNF?, and transforming growth factor-?2/-3, TGF-?2 or -?3) have a disruptive effect on BTB integrity, ..
  73. JULIE MARIE VOSE; Fiscal Year: 2016
    ..endothelial growth factor (VEGF), soluble Interleukin-2 receptor (slL2r), lnterleukein-12 (ILI 2), and tumor necrosis factor alpha (TNFa) in the post transplant period and correlate the results with the event-free survival (EFS) and ..
  74. DAVID ANTONETTI; Fiscal Year: 2016
    ..of growth factors such as vascular endothelial growth factor (VEGF) and inflammatory cytokines such as tumor necrosis factor (TNF)...
  75. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..development of neuroprotection induced by ischemic preconditioning;and 3) Morphine inhibits production of tumor necrosis factor-a (TNF-a) and MMP-2 from both the ocular hypertension and acute ischemia rat models...
  76. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
    ..endothelial growth factor (VEGF) and placental growth factor (PlGF);inflammatory cytokines such as tumor necrosis factor (TNF [unreadable]);and reactive oxygen species (ROS)...
  77. John J Krolewski; Fiscal Year: 2016
    ..a novel magnetic resonance imaging (CHESS-MRI) protocol to quantitate prostate regression and found that tumor necrosis factor (TNF) signaling is required, but not sufficient, for AWIA...
  78. Joseph M Zmuda; Fiscal Year: 2014
    ..bone loss with age;4) determine if higher concentrations of pro-inflammatory biomarkers, interleukin-6, tumor necrosis factor alpha and c-reactive protein, are each associated with accelerated loss of trabecular and cortical bone;and 5)..
  79. Effect of Antiviral CNS Penetration on CSF/Blood Cytokines and Depression in HIV
    Glenn J Treisman; Fiscal Year: 2013
    ..We hypothesize that increased CPE will decrease CSF and blood cytokines (Tumor Necrosis Factor-alpha, Interleukins-1, 6, and 12 and monocyte chemo attractant protein-1), thereby improving depression...
  80. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ..of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
  81. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  82. Ellen A Lipstein; Fiscal Year: 2016
    ..The research she proposes here uses the decision to initiate treatment with tumor necrosis factor-[unreadable] inhibitors (TNF[unreadable]i) as a model of complex pediatric treatment decisions...
  83. Mark J Czaja; Fiscal Year: 2016
    ..Studies have focused on how toxic injury alters hepatocyte responses to tumor necrosis factor-? (TNF) and reactive oxygen species (ROS) which are two central mediators of liver injury...
  84. LINDSAY T MARJORAM; Fiscal Year: 2015
    ..A central driver of the inflammatory response is tumor necrosis factor (TNF), a pro-inflammatory cytokine...
  85. Chandrasekhar Yallampalli; Fiscal Year: 2016
    ..b>Tumor necrosis factor- [unreadable] (TNF) caused differential and selective decreases in RAMPs or CRLR in VSM and endothelial ..
  86. JOAN MARIE BATHON; Fiscal Year: 2015
    ..The use of biologic agents that antagonize tumor necrosis factor (TNF) has resulted in decreased morbidity as well as clinically meaningful improvement in quality of life...
  87. Xiaogang Li; Fiscal Year: 2016
    ..applicant): The objective of this proposal is to continue our studies on understanding the mechanisms of tumor necrosis factor-alpha (TNF??) signaling in cystogenesis...
  88. Thomas Y Ma; Fiscal Year: 2016
    ..b>Tumor necrosis factor-[unreadable] (TNF-[unreadable]), a pro-inflammatory cytokine, has been shown to play a central role in the ..
  89. Suzanne Gaudet; Fiscal Year: 2016
    ..b>Tumor Necrosis Factor (TNF), a regulator of inflammation, is a particularly interesting model system for signal transduction ..
  90. Ashwin N Ananthakrishnan; Fiscal Year: 2016
    ..years, considerable progress has been made in the therapy of CD and UC with monoclonal antibodies against tumor necrosis factor [unreadable] (anti-TNF) representing the most significant therapeutic breakthrough...
  91. Yong Shen; Fiscal Year: 2014
    ..Inhibition of tumor necrosis factor and its mediated signal transduction pathway is one potential target area, like TNF type II receptor (..
  92. Creating a 3D dynamic in vitro model of the tumor microenvironment to characteriz
    LUIS FERNANDO ALONZO; Fiscal Year: 2013
    ..Of particular interest is TAM-derived tumor necrosis factor-alpha (TNF-), which is believed to cause the downregulation of cell adhesion molecules (e.g...
  93. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..Notably, NF-KB is one of the major human transcription factors that transcribes HIV-1;tumor necrosis factor alpha (TNFalpha) and LPS both stimulate NF-KB's binding to DNA...
  94. Victoria M Pak; Fiscal Year: 2014
    ..We hypothesize that a different frequency of polymorphisms in genes such as NOX-2, NOX p22phox, tumor necrosis factor-alpha (TNF-?), and PDE4D, will modify the degree of sleepiness symptoms in individuals with similar ..
  95. John H Kempen; Fiscal Year: 2014
    ..Primary findings included: 1) a suggestion of substantially increased overall and cancer mortality with Tumor Necrosis Factor (TNF) inhibitor therapy;2) no increased risk of overall and cancer mortality with antimetabolite, T-cell ..
  96. A first-in-class orally active anti-TNF-alpha inhibitor to treat AD
    Marni E Harris-White; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this proposal is to develop tumor necrosis factor [unreadable] (TNF[unreadable])-inhibiting compounds as neuroprotectant drugs for treating Alzheimer's disease (AD)...
  97. Kaladhar B Reddy; Fiscal Year: 2014
    ....
  98. COREY SIEGEL; Fiscal Year: 2016
    ..Recent studies have taught us that earlier, more intensive therapy with immunomodulator and anti-tumor necrosis factor (TNF) medications soon after diagnosis and before complications occur lead to better patient outcomes...
  99. Structural &Functional Studies of TLR/IL-1R Signaling
    Hao Wu; Fiscal Year: 2012
    ..In the extrinsic cell death pathway, death receptors (members of the tumor necrosis factor (TNF) receptor superfamily) such as Fas (also known as CD95 or APO-1) assemble into an oligomeric death ..
  100. Andre Levchenko; Fiscal Year: 2016
    ..forward a detailed plan of a more realistic integrative analysis of signaling in response to a chemokine, tumor necrosis factor (TNF)...
  101. OVARIAN TUMOR NECROSIS FACTOR
    Paul Terranova; Fiscal Year: 2004
    The objective of this application is to delineate the mechanisms by which tumor necrosis factor alpha (TNF) and in receptor system inhibit gonadotropin-stimulated ovarian granulosa cell estradiol secretion using a mouse model...