Gene Symbol: TNF-alpha
Description: tumor necrosis factor
Alias: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: human

Top Publications

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
  2. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
  3. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
  4. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
  5. pmc Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    Bertrand Boisson
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York, USA
    Nat Immunol 13:1178-86. 2012
  6. ncbi Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    Hideaki Kamata
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:649-61. 2005
  7. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
  8. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
  9. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
  10. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012

Detail Information

Publications415 found, 100 shown here

  1. ncbi Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    Olivier Micheau
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Cell 114:181-90. 2003
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated...
  2. doi TNF-alpha induces two distinct caspase-8 activation pathways
    Lai Wang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 133:693-703. 2008
    ..These findings revealed that TNF-alpha is able to induce apoptosis via two distinct caspase-8 activation pathways that are differentially regulated by cIAP1/2 and c-FLIP...
  3. ncbi The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    ..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct...
  4. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    ..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
  5. pmc Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
    Bertrand Boisson
    St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, New York, USA
    Nat Immunol 13:1178-86. 2012
    ..These data suggest that LUBAC regulates NF-κB-dependent IL-1β responses differently in different cell types...
  6. ncbi Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    Hideaki Kamata
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:649-61. 2005
    ..Antioxidant treatment also prevents TNFalpha-mediated fulminant liver failure without affecting liver regeneration...
  7. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  8. pmc Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population
    Hivana Patricia Melo Barbosa
    Laboratory of Immunogenetics, Federal University of Para, 66075 110 Belem, Brazil
    World J Gastroenterol 15:1465-71. 2009
    ..To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha polymorphisms, infection by Helicobacter pylori (H pylori) and the development of gastrointestinal diseases...
  9. doi The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
    Aya Shiraki
    Saga University Faculty of Medicine Department of Cardiovascular and Renal Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Atherosclerosis 221:375-82. 2012
    ..However, the effects upon endothelial cells and the mechanisms involved are not fully understood. We assessed the hypothesis that GLP-1 has protective effects against inflammation and oxidative stress on human endothelial cells...
  10. pmc TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    Adam P Gregory
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nature 488:508-11. 2012
    ..Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation...
  11. pmc HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells
    Elena Martinelli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:3396-401. 2007
  12. ncbi Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population
    Wanli Lu
    Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Institute for Cancer Research, Beijing Cancer Hospital, Beijing 100036, People s Republic of China
    Carcinogenesis 26:631-6. 2005 assess the association between genetic polymorphisms in interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor alpha (TNFalpha), which are involved in H.pylori infection, and risk of gastric cancer...
  13. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
  14. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
    ..It is possible that OGG1 and p53 and TNF-α proteins together or separately may be involved in pathogenesis of AD by repair of oxidative DNA damage and/or apoptosis...
  15. pmc Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha
    Sinead M Flannery
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 286:23688-97. 2011
    ..Collectively, these data demonstrate for the first time an essential role for IRAK-2 in primary human cells for both transcriptional and post-transcriptional TLR responses...
  16. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    ..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
  17. ncbi IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
    H Wesche
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 274:19403-10. 1999
    ..The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family...
  18. ncbi Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    S Muller
    German Diabetes Clinic, German Diabetes Research Institute at the University of Düsseldorf, Dusseldorf, Germany
    Diabetologia 45:805-12. 2002
    ..A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance...
  19. pmc TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis
    Youde Jiang
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Cell Signal 24:1086-92. 2012
    ..Resolution of the hyperglycemia-induced TNFα levels in retinal endothelial cells may prevent apoptosis through disinhibition of insulin receptor signaling...
  20. pmc Inflammatory mediators in breast cancer: coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition
    Gali Soria
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Israel
    BMC Cancer 11:130. 2011
    ..In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and to identify the possible implications of these factors to disease course...
  21. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
    ..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells...
  22. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-..
  23. pmc Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R8. 2009
    ..TNFalpha activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFalpha-regulated gene expression in chondrocytes is unknown...
  24. ncbi c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan
    J Biol Chem 278:9944-52. 2003
    ..These two pathways converge at IKKbeta and go on to activate NF-kappaB, via serine phosphorylation and degradation of IkappaB-alpha, and, finally, to initiate ICAM-1 expression...
  25. ncbi Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea
    Ja Young Lee
    Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong gu, Seoul 134 701, South Korea
    Cancer Lett 225:207-14. 2005
    ..pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea...
  26. doi Autoimmune hepatitis, HLA and extended haplotypes
    Lea Campos Oliveira
    Laboratório de Pediatria Clinica LIM 36, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Sao Paulo, Brazil
    Autoimmun Rev 10:189-93. 2011
    ..We genotyped 107 AIH-1 children and up to 326 healthy subjects for TNFA G-308A, TNFA G-238A, LTA A+252G, LTA A+80C, NFKBIL1 T-63A, BAT1 C-348T, BAT1 G-22C, MICA, and HLA-B polymorphisms...
  27. pmc Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    Paul D Upton
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s and Papworth Hospitals, Cambridge CB2 2QQ, UK
    J Biol Chem 284:15794-804. 2009
    ..This differential signaling may contribute to the contrasting pathologies of hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension...
  28. pmc Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation
    Ananthamurthy Nagabhushana
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    PLoS ONE 6:e17477. 2011
    ..These results suggest that optineurin regulates NF-κB activation by mediating interaction of CYLD with ubiquitinated RIP thus facilitating deubiquitination of RIP...
  29. doi HO-1 underlies resistance of AML cells to TNF-induced apoptosis
    Stuart A Rushworth
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK
    Blood 111:3793-801. 2008
    ..These results demonstrate a novel mechanism by which TNF-induced cell death is inhibited in AML cells through the induction of HO-1, via Nrf2 activation...
  30. ncbi Frequency of distribution of inflammatory cytokines IL-1, IL-6 and TNF-alpha gene polymorphism in patients with obstructive sleep apnea
    K Popko
    Department of Laboratory Medicine and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland
    J Physiol Pharmacol 59:607-14. 2008
    ..The study revealed a significant correlation between polymorphism located in the promoter region of inflammatory cytokine genes and obesity-related OSAS...
  31. pmc Inflammatory response gene polymorphisms and their relationship with colorectal cancer risk
    Janina Suchy
    International Hereditary Cancer Center Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
    BMC Cancer 8:112. 2008
    ..This fact suggests that genetic variations in inflammatory response genes may act as CRC disease risk modifiers...
  32. doi Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia
    Migraci Tosun
    Department of Obstetrics and Gynecology, Ondokuz Mayis University, Samsun, Turkey
    J Matern Fetal Neonatal Med 23:880-6. 2010
    ..A particular objective was the comparison of normal umbilical serum levels to preeclamptic values...
  33. doi Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts
    Hiroyuki Eda
    Discovery Biology, Global Research and Development, St Louis Laboratories, Pfizer Inc, 700 Chesterfield Parkway West, mail zone AA3C, Chesterfield, MO 63017, USA
    Rheumatol Int 31:1525-30. 2011
  34. doi The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis
    Yu Yang
    Department of Oncology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    J Cancer Res Clin Oncol 137:947-52. 2011
    ..The aim of this study was to determine more precise estimations for the relationship between TNF-α, IL-1B, and IL-10 polymorphisms and the risk for HCC by meta-analysis...
  35. pmc Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes
    Monika A Niewczas
    Research Division of Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 4:62-70. 2009
    ..The aim of our study was to examine serum markers of the TNF and Fas pathways for association with cystatin-C based estimated glomerular filtration rate (cC-GFR) in subjects with type 1 diabetes (T1DM) and no proteinuria...
  36. pmc TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures
    Nadine Tarantino
    Unité de Signalisation Moléculaire et Activation Cellulaire and 2 Laboratoire Trafic Membranaire et Division Cellulaire, Institut Pasteur, Centre National de la Recherche Scientifique URA 2582, Paris 75015, France
    J Cell Biol 204:231-45. 2014
    ..Thus, different mechanisms are involved in the recruitment of NEMO into supramolecular complexes, which appear to be essential for NF-κB activation. ..
  37. pmc TNFα enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands
    Prakash Radhakrishnan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Biophys Res Commun 409:436-41. 2011
    ..These results support the hypothesis that inflammation contributes to cancer metastasis...
  38. doi Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder
    Pichili Vijaya Bhaskar Reddy
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Neurochem Res 37:1697-706. 2012
    ..Taken together, these results suggest a possible protective role of Nrf2 in regulating the levels of pro-oxidative and pro-inflammatory molecules in HAND...
  39. doi META060 attenuates TNF-α-activated inflammation, endothelial-monocyte interactions, and matrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 in THP-1 monocytes
    Anuradha Desai
    Metagenics, Inc, Gig Harbor, WA 98332, USA
    Atherosclerosis 223:130-6. 2012
    ..A modified hop extract, META060, was identified as an inhibitor of inflammatory mediators in human rheumatoid arthritis synovial fibroblasts...
  40. ncbi Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection
    S Barrett
    Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin, Ireland
    J Med Virol 71:212-8. 2003
    ..Inheritance of some genotypes associated with polymorphisms of cytokine genes, such as IL-6, may be host genetic factors associated with outcome of HCV in a well-defined ethnically homogeneous cohort...
  41. doi A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia
    Cui Xie
    Central Laboratory and Center of Prenatal Diagnosis, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, People s Republic of China
    Cytokine 56:550-9. 2011
    ..Our findings strengthen the clinical evidence that PE is accompanied by exaggerated inflammatory responses, but do not support TNF-α-308G/A, IL-6-174G/C, and IL-10-1082A/G as candidate susceptibility loci in PE...
  42. doi Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1ß toxicity through AdipoR1
    Ersilia Nigro
    CEINGE Biotecnologie Avanzate scarl, Naples, Italy
    Int J Biochem Cell Biol 45:1145-53. 2013
    ..Further studies are needed to fully elucidate the Acrp30 lung effects in vivo but our results confirm this adipokine as a promising therapeutic target in lung diseases...
  43. doi Systemic cytokine response in patients with community-acquired pneumonia
    H Endeman
    Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Eur Respir J 37:1431-8. 2011
    ..IL-1RA, IL-6, IL-8 and IL-10 are acute phase proteins, independent of genotype. Their levels are influenced by the nature of the causative microorganism and the start of corticosteroids therapy...
  44. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
    ..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO...
  45. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
    ..FDCs produced soluble tumor necrosis factor alpha (TNF-alpha) ex vivo, and the addition of a blocking soluble TNF receptor ablated FDC-mediated HIV ..
  46. doi TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis
    Ioanna Tsagaraki
    Institute of Biology, National Center for Scientific Research Demokritos, 15310 Agia Paraskevi, Athens, Greece
    Cell Tissue Res 342:87-96. 2010
    ..The biological role of this interaction was revealed by the use of echistatin, an antagonist of αvβ3 integrin. In the presence of echistatin, decreased protection against apoptosis by recombinant TIMP-1 was observed...
  47. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  48. pmc Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells
    Mostafa A Gabr
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Orthop Res 29:1-7. 2011
    ..IL-17 may be an important regulator of inflammation in the IVD pathologies...
  49. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    ..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes...
  50. ncbi The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome
    Silvia Sookoian
    Cardiologia Molecular, Instituto de Investigaciones Medicas A Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Hypertens 18:1271-5. 2005
    ..We investigated the possible contribution of the G-308A TNF-alpha mutant to explain variables of the metabolic syndrome...
  51. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  52. doi PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells
    Konstantin Tsoyi
    Department of Pharmacology, Institute of Health Sciences, School of Medicine, and Biomedical Center BK21, Gyeongsang National University, 92 Chilam dong, Jinju 660 751, Republic of Korea
    Atherosclerosis 213:115-21. 2010
    ..It is concluded that PTEN selectively inhibits expression of VCAM-1 but not ICAM-1 through modulation of PI3K/Akt/GSK-3β/GATA-6 signaling cascade in TNF-α-treated ECs...
  53. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor alpha (TNF-alpha) using PCR-based genotyping assays...
  54. pmc Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles
    Danielle B Peterson
    Department of Surgery, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Proteomics 8:2430-46. 2008
    ..These observations provide fundamental insight into the mechanisms regulating the production of these particles and their physiological role in numerous diseases...
  55. doi Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α
    Rebecca K Studer
    VA Pittsburgh, Pittsburgh, PA, USA
    Spine (Phila Pa 1976) 36:593-9. 2011
    ..CONCLUSION.: The results suggest maneuvers to diminish IL-6 production in the disc could provide some protection against the adverse effects of IL-1 and TNF-α, thus, helping preserve disc composition, structure, and function...
  56. ncbi Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation
    Mohamed Hassan
    Department of Dermatology, Faculty of Medicine, University of Duesseldorf, Mooren Strasse 5, 40225 Duesseldorf, Germany
    Cell Signal 19:301-11. 2007
    ..patients is associated with the production of serum and interhepatic inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha)...
  57. doi Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1
    Maria J Smolinska
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford University, London W6 8LH, United Kingdom
    J Immunol 187:6043-51. 2011
    ..These data highlight the importance of Hck as an active component in LPS-induced TLR signaling and suggest the possibility of targeting this kinase for the alleviation of excessive inflammation...
  58. ncbi Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer
    Chuen Ming Shih
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Lung Cancer 52:15-20. 2006
  59. ncbi Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases
    Thorsten Hagemann
    Department of Haematology Oncology, Georg August University, Gottingen, Germany
    Carcinogenesis 25:1543-9. 2004
    ..In summary, we have found that co-cultivation of tumour cells with macrophages leads to enhanced invasiveness of the malignant cells due to TNF-alpha dependent MMP induction in the macrophages...
  60. doi Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells
    Hatim Hemeda
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany
    Stem Cells Dev 19:693-706. 2010
    ..Altogether, our data show that properties of MSCs depend on local environmental factors. In particular, we have shown that IFN-gamma and TNF-alpha differentially regulate cytokine expression and migration of MSCs...
  61. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..and cross-talk with insulin, 3T3-L1 adipocytes were cultured for different times with IL-6 and tumor necrosis factor alpha (TNF-alpha)...
  62. doi Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
    Jan Hendrik Egberts
    Division of Molecular Oncology, Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 68:1443-50. 2008
    ..In the present work, we investigated the role of the major proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) in the malignancy of PDAC cells in vitro and in vivo...
  63. ncbi Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    Nicolas W J Schröder
    Institut für Mikrobiologie und Hygiene, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat zu Berlin, Dorotheenstrasse 96, D 10117 Berlin, Germany
    J Biol Chem 278:15587-94. 2003
    ..However, the involvement of TLR-4 and MD-2 in this process was ruled out...
  64. pmc S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 283:35375-82. 2008
    ..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling...
  65. doi Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways
    Fabrizio Montecucco
    Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
    Cell Signal 20:557-68. 2008
    ..Although highly speculative, ERK 1/2 p44 may represent a selective target for the pharmacologic manipulation of neutrophil-mediated adverse activities in TNF-alpha-mediated inflammatory states...
  66. pmc Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity
    Lara Buscemi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Neurobiol Dis 26:661-70. 2007
  67. ncbi TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients
    Sandra A Drigo
    Heart Institute InCor, School of Medicine, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar 44, Bloco 2, 9 andar, CEP 05403 001 São Paulo, Brazil
    Microbes Infect 8:598-603. 2006
    ..We typed the TNFa microsatellite and the -308 TNF promoter polymorphism and then analyzed the survival curves of 42 patients with ..
  68. ncbi IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma
    Gifone Aguiar Rocha
    Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Int J Cancer 115:678-83. 2005
    ..Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian ..
  69. ncbi Autoimmunity and tuberculosis. Opposite association with TNF polymorphism
    Paula A Correa
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas CIB, Medellin, Colombia
    J Rheumatol 32:219-24. 2005
  70. doi Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population
    Silvia Jiménez-Morales
    Genomic of Complex Diseases Laboratory, Instituto Nacional de Medicina Genomica, SS, Mexico City, Mexico
    Hum Immunol 70:251-6. 2009
    ..89, p = 0.004). These results support the concept that the TNF-alpha gene is a genetic risk factor for asthma, SLE, and JRA in the pediatric Mexican population...
  71. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  72. pmc Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites
    Stephen J Wort
    Department of Critical Care, National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 284:24297-305. 2009
    ..synergistic induction of preproET-1 message RNA and release of mature peptide by a combination of tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) in primary human pulmonary artery smooth muscle cells...
  73. doi Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naïve monocytes to produce TNF-alpha through cellular cross-talk
    Hang Xie
    Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Cell Microbiol 10:1453-67. 2008
    ..These results suggest that M. catarrhalis LOS could induce excessive middle ear inflammation through a cellular cross-talk mechanism during OME...
  74. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
    ..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control...
  75. pmc Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population
    Muhammad Imran Khan
    Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
    Mol Vis 15:2861-7. 2009
    The purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in ..
  76. ncbi Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population
    P Kummee
    Inter Department of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
    J Viral Hepat 14:841-8. 2007
    ..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection...
  77. ncbi FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
    Mani Alikhani
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:12096-102. 2005
    ..siRNA silencing also blocked down-regulation of anti-apoptotic genes. These results indicate that TNF induces activation of the FOXO1 transcription factor, which acts as a master switch to control apoptosis...
  78. doi Tumor necrosis factor-alpha gene -308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women
    Yael T Joffe
    University of Cape Town Medical Research Council Research Unit for Exercise Science and Sports Medicine, Cape Town, South Africa
    J Nutr 140:901-7. 2010
    ..This study explored interactions between dietary fat intake and the tumor necrosis factor-alpha (TNFA) -308 G/A polymorphism on obesity, insulin resistance, and serum lipid concentrations in urbanized black SA women...
  79. ncbi Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study
    J P Mira
    Intensive Care Unit, Cochin Port Royal University Hospital, Paris, France
    JAMA 282:561-8. 1999
    b>Tumor necrosis factor alpha (TNF-alpha) is believed to be a cytokine central to pathogenesis of septic shock...
  80. pmc Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production
    Nicole J Horwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London W6 8LH, United Kingdom
    J Exp Med 197:1603-11. 2003
    ..Inhibitors capable of blocking the signaling events that result in TNF alpha production could provide useful therapeutics for treating septic shock and other inflammatory diseases...
  81. doi Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle
    Miranda D Grounds
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia, Australia
    Clin Exp Pharmacol Physiol 35:846-51. 2008
  82. ncbi Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways
    Xianghuai Lu
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033, USA
    J Biol Chem 281:6297-306. 2006
    ..The inhibitory effect of TNF on Osx expression may decrease OB differentiation in arthritis and osteoporosis...
  83. ncbi Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes
    Seong Su Nah
    Division of Allergy and Rheumatology, Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    FEBS Lett 581:1928-32. 2007
    ..In conclusion, accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha...
  84. ncbi Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease
    Maqsood M Elahi
    Department of Human Sciences, Human Genetics Laboratory, Loughborough University, Leicestershire, UK
    Biochim Biophys Acta 1792:163-72. 2009
    ..This review discusses the genetics of the TNF-alpha -308 polymorphism in selected major diseases and evaluates its common role in health and disease...
  85. doi Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma
    Mohammad Reza Razeghinejad
    Department of Ophthalmology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Ophthalmic Res 42:118-24. 2009
    ..Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study.
  86. ncbi The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept
    Lindsey A Criswell
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA
    Arthritis Rheum 50:2750-6. 2004
    ..To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA)...
  87. ncbi Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    Biochem Biophys Res Commun 335:1254-63. 2005
    ..Our data suggest that adiponectin constant presence in the circulation in high levels (in lean subjects) renders macrophages resistant to pro-inflammatory stimuli, including its own...
  88. doi Tumor necrosis factor region polymorphisms are associated with AIDS and with cytomegalovirus retinitis
    Neifi H S Deghaide
    Division of Clinical Immunology, Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    AIDS 23:1641-7. 2009
    ..necrosis factor (TNF) gene is located within the highly polymorphic major histocompatibility complex region, exhibiting the -308 GA promoter region polymorphism and six microsatellites (TNFa-f) spanning the region nearby the TNF locus.
  89. doi TNF microsatellite alleles may confer protection against the development of lipodystrophy syndrome in Brazilian HIV patients
    M M Silva
    Department of General and Specialized Nursing, College of Nursing of Ribeirão Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    Int J Immunogenet 37:379-85. 2010
    The aim of this study was to evaluate the frequency of TNFa-e microsatellites and the promoter region (TNF-308 and TNF-238) in HIV/AIDS-infected patients presenting or not lipodystrophy syndrome (LS)...
  90. doi Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus
    A Rana
    Department of Immunopathology, Post Graduate Institute of Medical Education and Research, India
    Lupus 21:1105-12. 2012
  91. doi Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis
    M Bashashati
    Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Neurogastroenterol Motil 24:1102-e566. 2012
    ..This may be due to small sample sizes and differences in ethnicities. Therefore, we performed a meta-analysis on the studies that investigated cytokine gene polymorphisms in IBS patients compared to healthy controls...
  92. doi Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes
    Juan Xue
    Department of Urology, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P R China
    Mol Med Rep 8:1755-60. 2013
    ..To the best of our knowledge, this is the first evidence of crosstalk between TNF-α and ADAMTS-4 in relation to OA cartilage degradation, which adds novel insight into the pathophysiology of OA and cartilage degradation...
  93. ncbi Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease
    Ming Yuh Shiau
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    Clin Biochem 40:213-7. 2007
  94. doi Mechanism of TNF-α-induced migration and hepatocyte growth factor production in human mesenchymal stem cells
    Aibin Zhang
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    J Cell Biochem 111:469-75. 2010
    ..We conclude that TNF-α can enhance human MSCs migration and stimulate their production of HGF. These effects are mediated via a specific TNF receptor and signaling pathways...
  95. ncbi Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes
    Roland Schmidt
    Deutsches Herzzentrum und I Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Lazarettstr 36, 80636 München, Germany
    Circ Res 102:302-9. 2008
    ..Thus, EMMPRIN may represent a novel target to diminish the burden of protease activity and inflammation in atherosclerosis...
  96. pmc Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis
    Le Zhuang
    Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China
    PLoS ONE 8:e68827. 2013
    ..Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk...
  97. ncbi Genetic polymorphisms of tumor necrosis factor-alpha modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations
    Bénédicte Fontaine-Bisson
    Department of Nutritional Sciences and Nutrition, University of Toronto, Toronto, Canada
    Am J Clin Nutr 86:768-74. 2007
    ..Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that can induce hyperlipidemia and is known to be modulated by dietary PUFAs...
  98. ncbi Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies
    H Chinoy
    The University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD
    Rheumatology (Oxford) 46:1411-6. 2007
    ..To investigate haplotype tagging single nucleotide polymorphisms (SNPs) in the tumour necrosis factor alpha (TNF-alpha) gene, in UK Caucasian idiopathic inflammatory myopathy (IIM) patients...
  99. ncbi Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNFalpha in human epidermal keratinocytes (HaCaT)
    Kenji Onda
    Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 351:266-72. 2006
  100. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
  101. doi Tumor necrosis factor-α levels correlate with postoperative pain severity in lumbar disc hernia patients: opposite clinical effects between tumor necrosis factor receptor 1 and 2
    Pablo Andrade
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Pain 152:2645-52. 2011
    ..Moreover, the opposite correlation of TNF receptors with pain sensation suggests that an unbalanced expression plays a role in the generation of pain...

Research Grants109 found, 100 shown here

  1. The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    Tomoki Hashimoto; Fiscal Year: 2013
    ..This study will be a basis for future studies to test pharmacological therapies that target mast cells or mast cells-derived cytokines for the prevention of aneurysmal subarachnoid hemorrhage. ..
  2. Central cholinergic regulation of inflammation
    ..The effect of galantamine on the systemic cytokine response and survival and its dependence on specific brain dysfunction will be evaluated in therapeutic settings. ..
  3. Wnt-4 inhibits peridontitis by attenuating NF-kB
    Cun Yu Wang; Fiscal Year: 2013
    ..The results should provide an important proof-of-principal in the prevention and treatment of periodontitis by targeting NF-kB, and lay the important foundation for the clinical trials involving the IKK/NF-kB inhibitors. ..
  4. Structural and functional studies of the IkappaB kinase (IKK) complex
    Hao Wu; Fiscal Year: 2013
    ..In addition, the proposed studies will provide a structural basis for discovery and optimization of IKK inhibitors in the treatment of inflammatory diseases and cancer. ..
  5. Chronic rhinosinusitis-associated olfactory loss
    Andrew P Lane; Fiscal Year: 2013
    ..b>Tumor necrosis factor alpha (TNF-1) is a prominent cytokine in CRS that also has diverse effects on neurons...
  6. MicroRNAs in Endothelial Cell Activation.
    Yajaira Suarez; Fiscal Year: 2013
    ..contribute to a better understanding of the cellular and molecular mechanisms that control EC activation and may identify potential therapeutic strategies for the regulation of endothelial activation through modulation of miRNA activity! ..
  7. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
  8. Radiation-Induced Osteoporosis in Women with Cancer: Mechanisms and Prevention
    Ted A Bateman; Fiscal Year: 2013
    ..early inflammatory response to radiation damage) of osteoclasts via the cytokines tumor necrosis factor-alpha (TNFa) and interleukin-1 (IL-1)...
  9. Suppression of vascular endothelial cell inflammation
    Xiao Feng Yang; Fiscal Year: 2013
    ..abstract_text> ..
  10. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
    ..In Aim 3, we will use pharmacological inhibition of ADAM17 released cytokines tumor necrosis factor alpha (TNFa) and interleukin 6 receptor (IL6R) to test for their influence on the etiology of pancreatic ..
  11. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..Exploratory aims are to (1) explore the relationships among selected markers of inflammation (tumor necrosis factor alpha [TNF-1], interleukin-6 [IL-6], interleukin-IL1-2 [IL1-2], and C-reactive protein [CRP]), symptoms and ..
  12. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..Endothelial cells reprogram their transcriptional network in response to cytokine stimulation such as tumor necrosis factor alpha (TNF1), interleukin (IL), lipopolysaccharide (LPS), or interferons (IFNs)...
  13. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..abstract_text> ..
  14. The role of Fas-associated death domain in necroptosis in vivo
    Astar Winoto; Fiscal Year: 2013
    ..Successful completion of these aims will greatly enhance our understanding of the host- pathogen interaction and the physiological role of necroptosis. ! ! ! ..
  15. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013 a key aspect of airways disease, and exposure to several inflammatory mediators (such as tumor necrosis factor (TNFa) and interleukin-13 (IL-13)) increase ASM contractility...
  16. Role of the M1 macrophage response in the progression of chronic kidney disease
    Steven D Crowley; Fiscal Year: 2013
    ..Examining these pathways should lead to more effective strategies for preventing progressive CKD. ..
    DOUGLAS LOWELL MANN; Fiscal Year: 2013
    ..abstract_text> ..
  18. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..Understanding this mechanism will allow us to find new medications that stimulate new bone formation and regeneration of tissue in veterans who suffer from arthritis, aging, and menopause associated fractures. ..
  19. Predictors and Targets of Response to Cytokine Antagonism in Depression
    Andrew H Miller; Fiscal Year: 2013
    ..placebo responders and non-responders. These data will provide important clues regarding relevant predictors and targets of response to cytokine antagonism and will inform the design of future immune-based therapeutic trials. ..
  20. Cytokine Balance in Rheumatoid Arthritis
    Lionel B Ivashkiv; Fiscal Year: 2013
    ..These studies will potentially yield insights into mechanisms of TNF action that can be therapeutically targeted while preserving acute functions of TNF that are important in host defense. ..
  21. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved. ..
  22. Sepsis Outcomes and Aging: Role of Sleep Disruption and the Blood Brain Barrier
    Mark R Opp; Fiscal Year: 2013
  23. Novel therapies in alcoholic hepatitis University of Louisville
    Craig J McClain; Fiscal Year: 2013
  24. Persistent COMT-dependent Pain: Role of beta-adrenergic Receptors
    ANDREA G NACKLEY NEELY; Fiscal Year: 2013
    ..g., beta2- and beta3ARs) for development of effective therapies for patients with persistent pain conditions.]] ..
  25. The role of the inflammatory response in bone and cartilage changes following non
    ..During the mentored period I will successfully transition from the mentored stage of my career to an independent investigator. ..
  26. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
  27. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..This proposal aims to investigate an understudied topic in an innovative system by testing novel hypotheses. Our efforts would ultimately lead to safer surgical care and better post-operative outcomes for senior patients. ..
  28. The involvement of IL-12 and IL-27 in immunity to Mycobacterium tuberculosis
    CORY MICHAEL ROBINSON; Fiscal Year: 2013
    ..We have proposed basic research into host immune responses during infection that could have implications in design of therapeutic strategies and vaccines. ..
  29. Analysis of Coding Variants Associated with Age-Related Phenotypes
    ..The proposed research will further my development as an independent investigator and give me valuable experience in the meaningful application of human genetics tools to aging research. ..
  30. Role of Th1 Immune Responses in the Pathogenesis of Hypertensive Kidney Injury
    Steven D Crowley; Fiscal Year: 2013
    ..Understanding how Th1 immune responses influence angiotensin II-induced renal damage should lead to more effective strategies for preventing progressive chronic kidney disease. ..
  31. TNF Alpha in PKC Epsilon Signaling to Carcinogenesis
    Ajit K Verma; Fiscal Year: 2013
    ..development of squamous cell carcinoma (SCC) via increased expression of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF1) and granulocyte colony-stimulating factor (G-CSF) which may directly promote the proliferation ..
  32. Epigenetics and Psychoneurologic Symptoms in Women with Breast Cancer
    Debra E Lyon; Fiscal Year: 2013
    ..disturbances;pain), inflammatory activation [(levels of C- reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1B), and interleukin 6 (IL- 6)], and epigenetic alterations in 75 women ..
  33. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
  34. Regulation of IL-6 mediated inflammation and tissue destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2013
    ..Successful completion of this study will lay the foundation for testing EGCG as a treatment option for RA and other inflammatory diseases. ..
  35. Inducible Renitence in Macrophages
    Joel A Swanson; Fiscal Year: 2013
    ..Therapies which increase renitence selectively could reduce inflammation due to micro-particulates or benefit immunosuppressed patients and individuals with chronic inflammatory diseases, such as therosclerosis and Crohn's disease. ..
  36. GPCR Kinase-2 in TNFalpha Signaling in Macrophages
    Narayanan Parameswaran; Fiscal Year: 2013
    ..Taken together, our studies should provide important insight into the mechanisms of TNF signaling in macrophages as well as identify potential therapeutic targets in the treatment of chronic inflammatory diseases. ..
  37. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..Elucidating mechanisms by which APAP-induced liver injury progresses is essential for defining novel strategies to prevent liver failure in patients and for the general understanding of the pathogenesis of drug-induced liver injury. ..
  38. Mechanisms of hepcidin effects in the anemia of chronic disease
    Robert T Means; Fiscal Year: 2013
    ..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
  39. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..Extensive work, including our Preliminary Studies, suggests that inhibition of neutral ceramidase may provide a new therapy for these diseases. The proposed studies will provide the first test of this hypothesis. ..
  40. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
  41. Intrinsic Repair of the Knee Meniscus
    Farshid Guilak; Fiscal Year: 2011
    ..synthesis;(3) determine the interaction of mechanical stress with interleukin 1, interleukin 17, and tumor necrosis factor alpha in the production of pro-inflammatory mediators, and (4) determine the interaction between the NO and ..
  42. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..through the CXCR4 receptor can: 1) stimulate Schwann cells to release RANTES and then induce release of tumor necrosis factor alpha (TNF1) from dorsal root ganglion (DRG) neuron;and 2) activate glia to release TNF1...
  43. Macrophages and TLR4 in Ischemic Acute Kidney Injury (AKI)
    JOHN ROBERT HARTONO; Fiscal Year: 2010
    ..Despite modern treatment, there has been very little improvement in treating acute kidney injury (AKI). This proposal will investigate how the immune system mediates the kidney's initial response to AKI and its subsequent repair. ..
  44. HIV-1 regulation by MTb: pathogen and host factor
    Anne Goldfeld; Fiscal Year: 2010
    ..abstract_text> ..
  45. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..Finally, this project provides an opportunity for undergraduates at Boise State University to participate in biomedical research and gain an appreciation of the complex regulatory mechanisms that govern regeneration. ..
  46. IL-1?? as a mediator of maternal infection-induced effects on offspring neuroinfl
    Heping Zhou; Fiscal Year: 2010
    ..Our results may also contribute to the finding of new diagnostic or therapeutic targets for mitigating maternal infection-induced defects in the offspring. ..
  47. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    Fabio Cominelli; Fiscal Year: 2009
    ..abstract_text> ..
    John M Kyriakis; Fiscal Year: 2010
    ..These studies will provide important details of a previously unknown signaling pathway required for inflammatory responses. ..
  50. Innate Immune Bacterial Recognition and Osteoclastogenesis
    Caroline A Genco; Fiscal Year: 2010
    ..References numbers are found in the "Literature Cited" section of the original grant application. ..
  51. Pathogenic Mechanisms of Shiga Toxins
    Vernon L Tesh; Fiscal Year: 2010
    ..An improved understanding of how these toxins cause disease is necessary to formulate effective therapeutic agents to block disease progression. ..
  52. Optoid Analgesics: Modulation of Trigeminal & Spinal Glial Activation
    Linda Watkins; Fiscal Year: 2010
    ..If successful, these studies will lead to development of novel adjunct therapies for improving clinical pain control by controlling the negative consequences of opioid-induced glial activation. ..
  53. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  54. Targeting host response to DAMP for therapy of Rheumatoid Arthritis
    Dexing Fang; Fiscal Year: 2011
    ..confirm the therapeutic effect of CD24Fc and compare CD24Fc with Enbrel, the clinically used soluble receptor for TNFa. In addition, we will establish an in vitro model to demonstrate the mode of action of the CD24Fc, as detailed in ..
  55. PARP-1 in Juvenile Idiopathic Arthritis-associated IL-10 Promoter Polymorphisms
    Jianguo Liu; Fiscal Year: 2011
  56. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
  57. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..This proposal will provide mechanistic insight into how TAX1BP1, Itch and A20 function together to inactivate key signaling molecules and restrict inflammatory signaling pathways. ..
  58. Adenosine Receptors and Atherogenesis
    Katya Ravid; Fiscal Year: 2012
    ..Taken together, our proposed investigations should shed new light on the role of A2bARs in the pathogenesis of vascular dysfunction, and could focus attention on A2bAR activation as a therapeutic target. ..
  59. Mechanisms of Pulmonary Mast Cell Recruitment and Maturation
    ..MCp in the allergen-challenged lung that depends on CD4+ cells and the cytokines interleukin (IL)-9 and tumor necrosis factor alpha (TNFa) although not on Th1 or Th2 cells...
  60. Stage-specific Impact of TNF-alpha Receptor Signaling in Alzheimer's Disease
    SARA LYNN MONTGOMERY; Fiscal Year: 2012
    ..abstract_text> ..
  61. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  62. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2012
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  63. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
    Frank B Hu; Fiscal Year: 2013
  65. Genetic Regulation of Indoleamine-2,3-dioxygenase and Psychiatric Complications o
    Gregory F Oxenkrug; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The proposed study aims to investigate whether analysis of cytokine gene polymorphisms might help to identify hepatitis C patients with high risk of developing psychiatric complications in response to IFN-alpha therapy ..
  66. Impact of Ambient Ultrafine Particle Exposures on Alzheimer's Disease Progression
    MICHAEL KERRY O'BANION; Fiscal Year: 2013
    ..The findings will have profound implications for public health policy and will enable the development of therapeutic interventions for this debilitating and costly disease. ..
  67. Interactions among Depressive Symptoms and Genetic Influences on Cardiac Outcomes
    Lorraine Q Frazier; Fiscal Year: 2011
    ..Inflammatory proteins and genes include: Interleukin (IL) 6, C-reactive protein (CRP), Tumor Necrosis Factor Alpha (TNFa), E-Selectin (SELE) and Monocyte Chemoattractant Protein-1 (MCP-1)...
  68. Phase III infliximab for primary treatment of Kawasaki disease IND 11046 6/27/200
    Jane C Burns; Fiscal Year: 2012
    ..Levels of the pro-inflammatory cytokine tumor necrosis factor a (TNFa) are elevated during acute KD and levels are highest in children in whom coronary artery aneurysms subsequently ..
  69. Atlantic Coast Consortium for Asthma (ACC-A) AsthmaNet Clinical Site
    Stephen P Peters; Fiscal Year: 2013
    ..Companion protocols will examine corticosteroid resistance (RASS) and a possible genetic mechanism for resistance (IMMOST) in adults, and the efficacy of inhaled S-nitrosoglutathione (N30-201) (SNORT) in children. ..
  70. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012 fatty acids, serum total and free testosterone and IGF-1), and cytokines (c-reactive protein, tumor necrosis factor alpha and IL-6 as inflammatory biomarkers) after 16 weeks of training+Tp and detraining...
  71. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..P-gp at the brain endothelial cell is inhibited by lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF)...
  72. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  73. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..endothelial growth factor (VEGF), soluble Interleukin-2 receptor (slL2r), lnterleukein-12 (ILI 2), and tumor necrosis factor alpha (TNFa) in the post transplant period and correlate the results with the event-free survival (EFS) and ..
    DAVID ANTONETTI; Fiscal Year: 2013
    ..Further, the proposal will explore the link between vascular permeability and angiogenesis and the role of the tight junction protein occludin in endothelial cell growth control. ..
  75. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..Outcomes of this project will provide valuable leads in the discovery of more effective therapies that can delay or prevent vision loss associated with neurodegenerative diseases such as glaucoma. 5 ..
  76. Preeclampsia, IUGR and Hypertension: Targets for Treatment
    Joey P Granger; Fiscal Year: 2013
  77. An androgen-regulated cytokine network controls prostate apoptosis
    John J Krolewski; Fiscal Year: 2013
    ..Finally, Aim 3 tests the functional role of FLIP, determining if FLIP down-regulation can cooperate with pro- apoptotic cytokines to induce apoptosis and regression of normal prostate and PrCa in a murine model. ..
  78. Epidemiology of Bone Loss in African Men
    Joseph M Zmuda; Fiscal Year: 2013
    ..bone loss with age;4) determine if higher concentrations of pro-inflammatory biomarkers, interleukin-6, tumor necrosis factor alpha and c-reactive protein, are each associated with accelerated loss of trabecular and cortical bone;and 5)..
  79. Effect of Antiviral CNS Penetration on CSF/Blood Cytokines and Depression in HIV
    Glenn J Treisman; Fiscal Year: 2013
    ..An insight into changes in CSF/blood pro-inflammatory cytokines associated with the CPE of ART may be helpful in developing HIV treatments that have an additional effect of improving mood. ..
  80. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ..of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
  81. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  82. Shared Decision Making In Pediatric Chronic Conditions: Biologics in IBD and JIA
    Ellen A Lipstein; Fiscal Year: 2013
    ..Lipstein's development into a nationally-recognized independent investigator and leader conducting research that improves the decision making process related to treatments for children with chronic conditions. ..
    Mark J Czaja; Fiscal Year: 2013
    ..The ultimate goal of these investigations is to better understand how hepatocytes are injured and die in order to prevent this process and the development of hepatic failure in human liver diseases. ..
  84. Epigenetic Regulation of Intestinal Inflammation
    LINDSAY T MARJORAM; Fiscal Year: 2013
    ..When crossed to an inflammation-responsive tnfa transgenic reporter line generated for this study, aa51...
  85. Sex Steroid Hormones and Calcitonin Gene-Related Peptide
    Chandrasekhar Yallampalli; Fiscal Year: 2013
  86. Inflammation and Cardiovascular Disease in RA
    Andreas H Hielscher; Fiscal Year: 2013
    ..A successful study would provide preliminary data for a more extensive grant application by a newly formed interdisciplinary team of NIAMS researchers. ..
  87. ADPKD: Understanding mechanisms, Discovering treatments.
    Xiaogang Li; Fiscal Year: 2013
    ..The information from our studies will be likely to open new avenues in the research of ADPKD and establish the foundation for developing effective therapies of the disease. ..
  88. TNF-alpha Regulation of Intestinal Paracellular Transport
    Thomas Y Ma; Fiscal Year: 2013
    ..abstract_text> ..
  89. Single-cell analysis of TNF-induced signaling, transcription and fate decisions
    Suzanne Gaudet; Fiscal Year: 2013
    ..These approaches will contribute to understanding the multi-factorial control of TNF-induced cell death and will be broadly applicable to the study of other signal transduction networks. ..
  90. Genetic predictors of anti-TNF treatment response and infections in IBD
    Ashwin Ananthakrishnan; Fiscal Year: 2013
    ..The methodology developed here will also have applications in other EMR-based cohorts to investigate novel therapeutic agents and disease outcomes. ..
  91. BACE1 regulation and TNFR Type II receptor in Alzheimers disease
    Yong Shen; Fiscal Year: 2013
    ..Thus, elucidating the regulatory mechanisms for BACE1 could identify new potential therapeutic targets and therefore diminish possible side effects that could arise by directly targeting BACE1. ..
  92. Creating a 3D dynamic in vitro model of the tumor microenvironment to characteriz
    LUIS FERNANDO ALONZO; Fiscal Year: 2013
    ..Most importantly, the impact of creating an in vitro 3D metastasis model with perfused human capillary bed could significantly enhance high-throughput anti-metastatic drug screening. ..
  93. Mechanisms of Sleepiness Symptoms in Sleep Apnea and Cardiovascular Disease
    Victoria M Pak; Fiscal Year: 2013
    ..Cardiovascular risk measures [ambulatory blood pressure (ABP) and Pulse-Wave Velocity (PWV)] will also be obtained at this time. We hypothesize that the symptoms of EDS are associated with increased cardiovascular risk measures. ..
  94. Opioid Impact on Trim37-Induced Restriction of HIV
    LAUREN BRITTANY BEACH; Fiscal Year: 2013
    ..Notably, NF-KB is one of the major human transcription factors that transcribes HIV-1;tumor necrosis factor alpha (TNFalpha) and LPS both stimulate NF-KB's binding to DNA...
  95. Complications of Immunosuppression for Eye Diseases
    John H Kempen; Fiscal Year: 2013
    ..Estimation of the relative (cost-) effectiveness of alternative immunosuppressants for ocular inflammation will greatly increase the quality of evidence available to guide rational clinical management. ..
  96. A first-in-class orally active anti-TNF-alpha inhibitor to treat AD
    Marni E Harris-White; Fiscal Year: 2013
  97. Racial Disparities in Breast Cancer and the role of micro-RNAs
    Kaladhar B Reddy; Fiscal Year: 2013
  98. Evaluating a Prediction Tool and Decision Aid for Patients with Crohn's Disease
    COREY SIEGEL; Fiscal Year: 2013
    ..Specifically, it focuses on communicating the best available individualized evidence to patients so that they can make an informed decision based on their expressed treatment preferences. ..
  99. Structural &Functional Studies of TLR/IL-1R Signaling
    Hao Wu; Fiscal Year: 2012
  100. Comparative analysis of information transfer in NF-kapppaB and MAPK pathways
    Andre Levchenko; Fiscal Year: 2013
    ..In this context, we propose to study in detail two signals induced by inflammation in mammalian cells. Through such analyses we anticipate to uncover novel principles and mechanisms by which cells respond to external stimuli. ..
    Paul Terranova; Fiscal Year: 2004
    The objective of this application is to delineate the mechanisms by which tumor necrosis factor alpha (TNF) and in receptor system inhibit gonadotropin-stimulated ovarian granulosa cell estradiol secretion using a mouse model...