TMPO

Summary

Gene Symbol: TMPO
Description: thymopoietin
Alias: CMD1T, LAP2, LEMD4, PRO0868, thymopoietin, LEM domain containing 4, TP alpha, TP beta/gamma, lamina-associated polypeptide 2, thymopoietin beta, thymopoietin-related peptide isoform alpha, thymopoietin-related peptide isoforms beta/gamma
Species: human

Top Publications

  1. ncbi LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya Japan, 464 8602
    J Cell Sci 112:2485-92. 1999
  2. pmc Three distinct human thymopoietins are derived from alternatively spliced mRNAs
    C A Harris
    Immunobiology Research Institute, Annandale, NJ 08801
    Proc Natl Acad Sci U S A 91:6283-7. 1994
  3. ncbi Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
    R Foisner
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    Cell 73:1267-79. 1993
  4. pmc Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics
    T Dechat
    nstitute of Biochemistry and Molecular Cell Biology, Biocenter and Institute of Tumor Biology Cancer Research, University of Vienna, A 1030 Vienna, Austria
    EMBO J 17:4887-902. 1998
  5. ncbi Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins
    T Dechat
    Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Sci 113:3473-84. 2000
  6. ncbi HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics
    S B Martins
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, Norway
    J Cell Sci 113:3703-13. 2000
  7. pmc Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    M Cai
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0510, USA
    EMBO J 20:4399-407. 2001
  8. ncbi Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)
    E Nili
    Pediatric Hemato Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    J Cell Sci 114:3297-307. 2001
  9. pmc Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein
    Ewa Markiewicz
    Department of Biological Sciences, The University of Durham, Durham DH1 3LE, United Kingdom
    Mol Biol Cell 13:4401-13. 2002
  10. ncbi LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Thomas Dechat
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
    J Cell Sci 117:6117-28. 2004

Research Grants

  1. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
  2. RICHARD LOWELL BELL; Fiscal Year: 2014
  3. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
  4. QTL MAPPING FOR ALCOHOL PREFERENCE IN SELECTED MICE
    Paula Bice; Fiscal Year: 2004
  5. Roles of BAF-Like in the nucleus
    Miriam Segura Totten; Fiscal Year: 2005
  6. Measuring the Aversive Effects of Alcohol Withdrawal
    JULIA CHESTER; Fiscal Year: 2006
  7. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
  8. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
  9. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications162 found, 100 shown here

  1. ncbi LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya Japan, 464 8602
    J Cell Sci 112:2485-92. 1999
    ..The chromatin- and lamin-binding activity of LAP2 suggests that LAP2 plays an important role in targeting mitotic vesicles to chromosomes and reorganizing the ..
  2. pmc Three distinct human thymopoietins are derived from alternatively spliced mRNAs
    C A Harris
    Immunobiology Research Institute, Annandale, NJ 08801
    Proc Natl Acad Sci U S A 91:6283-7. 1994
    b>Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function...
  3. ncbi Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation
    R Foisner
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    Cell 73:1267-79. 1993
    ..Together, these data suggest that LAP 2 may have a key role in initial events of nuclear envelope reassembly, and that both LAP 2 and LAP 1 may be involved in attaching lamins to the nuclear envelope...
  4. pmc Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics
    T Dechat
    nstitute of Biochemistry and Molecular Cell Biology, Biocenter and Institute of Tumor Biology Cancer Research, University of Vienna, A 1030 Vienna, Austria
    EMBO J 17:4887-902. 1998
    ..Some LAP2alpha may also associate with membranes prior to chromatin attachment. Altogether the data suggest a role of LAP2alpha in post-mitotic nuclear assembly and in the dynamic structural organization of the nucleus...
  5. ncbi Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins
    T Dechat
    Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, A 1030 Vienna, Austria
    J Cell Sci 113:3473-84. 2000
    The nucleoskeletal protein lamina-associated polypeptide 2(&agr;) (LAP2*) contains a large, unique C terminus and differs significantly from its alternatively spliced, mostly membrane-integrated isoforms, such as LAP2beta...
  6. ncbi HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics
    S B Martins
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, Norway
    J Cell Sci 113:3703-13. 2000
    ..Cross-linking experiments, however, illustrate a tight association of HA95 with LBR and LAP2 only...
  7. pmc Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    M Cai
    Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0510, USA
    EMBO J 20:4399-407. 2001
    The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved approximately 40-residue 'LEM' motif. Loss of emerin causes Emery-Dreifuss muscular dystrophy...
  8. ncbi Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)
    E Nili
    Pediatric Hemato Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine, Tel Aviv University, Israel
    J Cell Sci 114:3297-307. 2001
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein...
  9. pmc Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein
    Ewa Markiewicz
    Department of Biological Sciences, The University of Durham, Durham DH1 3LE, United Kingdom
    Mol Biol Cell 13:4401-13. 2002
    ..Together, these data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C complexes...
  10. ncbi LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Thomas Dechat
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
    J Cell Sci 117:6117-28. 2004
    ..We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly...
  11. ncbi The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation
    Raz Somech
    Sheba Cancer Research Center and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Cell Sci 118:4017-25. 2005
    ..Our data provide evidence for the existence of a previously unknown repressive complex, composed of an integral nuclear membrane protein and a histone modifier, at the nuclear periphery...
  12. ncbi Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
    Matthew R G Taylor
    CU Cardiovascular Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hum Mutat 26:566-74. 2005
    b>Thymopoietin or TMPO (indicated by its alternative gene symbol, LAP2, in this work) has been proposed as a candidate disease gene for dilated cardiomyopathy (DCM), since a LAP2 product associates with nucleoplasmic lamins A/C, which are ..
  13. pmc Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway
    Daniela Dorner
    Max F Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    J Cell Biol 173:83-93. 2006
    Lamina-associated polypeptide (LAP) 2alpha is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins...
  14. ncbi The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products
    R Berger
    Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Isreal
    Genome Res 6:361-70. 1996
    ..Here we report the isolation and characterization of seven mouse Tmpo mRNA transcripts named Tmpo alpha, beta, beta', gamma, epsilon, delta, and zeta...
  15. ncbi The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain
    K Furukawa
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:4213-9. 1998
    b>LAP2 is an integral protein of the inner nuclear membrane which binds lamins and chromosomes and is suggested to have an important role in nuclear envelope organization...
  16. ncbi Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin
    K Furukawa
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Eur J Biochem 251:729-33. 1998
    ..promote this localization, including the first (residues 1-296) and the second (residues 298-409) halves of the LAP2 N terminus. The second half is involved in LAP2 association with the nuclear lamina [Furukawa, K., Panté, N...
  17. ncbi Lamins in disease: why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?
    C J Hutchison
    The Department of Biological Sciences, The University of Durham, South Road, Durham DH1 3LE, UK
    J Cell Sci 114:9-19. 2001
    ..Several integral membrane proteins including emerin, LBR, LAP1 and LAP2 bind to nuclear lamins in vitro and can influence lamin function and dynamics in vivo...
  18. doi LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome
    Caroline Gaudy-Marqueste
    Service de Dermatologie, Hopital Ste Marguerite, Marseille, France
    J Med Genet 47:361-70. 2010
    ..search was undertaken for mutations in LMNA, encoding Lamins A/C, and ZMPSTE24, LBR, LMNB1, LMNB2, MAN1, SYNE1a and LAP2, encoding Lamins A/C molecular partners, in a Caucasian woman affected with Reynolds syndrome, a particular ..
  19. ncbi Distribution of emerin during the cell cycle
    M C Dabauvalle
    Department of Cell and Developmental Biology, Biocenter of the University of Wurzburg, Germany
    Eur J Cell Biol 78:749-56. 1999
    ..reassembly of the nuclear envelope at this mitotic stage emerin colocalizes with lamin A/C but not with lamin B and LAP2 proteins...
  20. pmc Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption
    Pallavi Gupta
    Faculty of Health Sciences, University of Ottawa, Ottawa, ON, K1H 8M5, Canada
    Basic Res Cardiol 105:365-77. 2010
    ..of 25 unrelated DCM patient samples for (a) cardiomyocyte nuclear abnormalities and (b) mutations in LMNA and TMPO as they are two DCM-causing genes that encode proteins involved in maintaining nuclear envelope architecture...
  21. ncbi Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes
    James M Holaska
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 15:3459-72. 2006
    ..Misregulation of 11 genes, including four (CREBBP, NAP1L1, LAP2, RBL2) known to be misregulated in X-EDMD patients and emerin-null mice [Bakay, M., Wang, Z., Melcon, G...
  22. pmc Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope
    K Furukawa
    Department of Biology, School of Science, Nagoya University, Japan
    EMBO J 14:1626-36. 1995
    Lamina-associated polypeptide 2 (LAP2) is an integral membrane protein of the inner nuclear membrane, which binds directly to both lamin B1 and chromosomes in a mitotic phosphorylation-regulated manner...
  23. ncbi Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy
    N Wolff
    Departement d Ingenierie et d Etudes des Proteines, CEA Saclay, Gif sur Yvette, France
    FEBS Lett 501:171-6. 2001
    ..in the two N-terminal domains of another inner nuclear membrane protein called lamina-associated protein 2 (LAP2)...
  24. pmc Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells
    Brenda R Baldwin
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cell Biol 24:3682-91. 2004
    ..C/EBP beta is expressed as several distinct protein isoforms (LAP1, LAP2, and LIP) whose expression is regulated by alternative translational initiation at downstream AUG start sites...
  25. ncbi Genomic structure and expression of parathyroid hormone-related protein gene (PTHrP) in a teleost, Fugu rubripes
    D M Power
    Centro de Ciências de MAR CCMAR, Universidade do Algarve, Campus de Gambelas, Faro, Portugal
    Gene 250:67-76. 2000
    ..Sequence scanning of overlapping cosmids has identified three additional genes, TMPO, LDHB and KCNA1, which map to human chromosome 12, with the latter two mapping to 12p12-11.2...
  26. ncbi Direct interaction between emerin and lamin A
    L Clements
    MRIC Biochemistry Group, N E Wales Institute, Wrexham, LL11 2AW, United Kingdom
    Biochem Biophys Res Commun 267:709-14. 2000
    ..An emerin-lamin A interaction system may be related in function to the LAP2-lamin B system at the inner nuclear rim.
  27. ncbi Drugs affecting prelamin A processing: effects on heterochromatin organization
    Elisabetta Mattioli
    IGM CNR, Unit of Bologna, c o IOR, Via di Barbiano 1 10 I 40136 Bologna, Italy
    Exp Cell Res 314:453-62. 2008
    ..At the biochemical level, heterochromatin-associated proteins and LAP2 alpha were clustered at the nuclear interior following FTI-277 treatment, while they were unevenly distributed or ..
  28. ncbi Identification of phosphorylation sites in native lamina-associated polypeptide 2 beta
    M Dreger
    AG Neurochemie, Institut fur Biochemie, Freie Universitat Berlin, Germany
    Biochemistry 38:9426-34. 1999
    ..Additionally, we identified for the first time at the protein level the LAP 2 splice variant LAP 2 epsilon in nuclear envelopes...
  29. ncbi Molecular cloning of soluble aminopeptidases from Saccharomyces cerevisiae. Sequence analysis of aminopeptidase yscII, a putative zinc-metallopeptidase
    N García-Alvarez
    Departamento de Biologia Funcional, Facultad de Medicina, Universidad de Oviedo, Spain
    Eur J Biochem 202:993-1002. 1991
    Plasmids capable of complementing lap1, lap2 and lap3 mutations [R.J. Trumbly and G. Bradley (1983) J. Bacteriol...
  30. ncbi The lamina-associated polypeptide 2 (LAP2) isoforms beta, gamma and omega of zebrafish: developmental expression and behavior during the cell cycle
    Vera K Schoft
    Division of Electron Microscopy, Biocenter of the University of Wü rzburg, Am Hubland, Germany
    J Cell Sci 116:2505-17. 2003
    ..The maternally synthesized omega is the largest isoform and the only LAP2 present in the rapidly dividing embryonic cells up to the gastrula stage...
  31. doi CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells
    David A Armstrong
    Research Service, Department of Veterans Affairs, White River Junction, VT 05009, USA
    Mol Cancer Res 7:1517-24. 2009
    ..DNA affinity chromatography studies showed that the LAP1, LAP2, and LIP isoforms of CEBPB bind to the IL-1beta-responsive CEBPB site in the MMP-1 promoter...
  32. ncbi TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes
    S Gonser
    Department of Pharmacy, ETH Zurich, Switzerland
    J Recept Signal Transduct Res 19:155-66. 1999
    The pentapetide thymopentin (TP5) corresponding to the aminoacids RKDVY represents the residues 32-36 of thymopoietin (TP), which was originally isolated from bovine thymus...
  33. ncbi Spin labeled antioxidants protect bacteria against the toxicity of alkylating antitumor drug CCNU
    Vesselina Gadjeva
    Department of Chemistry and Biochemistry, Medical Faculty, Thracian University, 11 Armeiska Str, 6000 Stara Zagora, Bulgaria
    Toxicol Lett 144:289-94. 2003
    ..of oxygen radical-scavenging substances [Vitamin E, stable nitroxyl radical 2,2,6,6-tetramethylpiperidine-N-oxyl (TMPO), and spin labeled (nitroxyl free radical moiety containing) analogues of CCNU] and compared with that of the ..
  34. pmc Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans
    Ayelet Margalit
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
    J Cell Biol 178:661-73. 2007
    ..to autointegration factor (BAF) binds double-stranded DNA, selected histones, transcription regulators, lamins, and LAP2-emerin-MAN1 (LEM) domain proteins...
  35. ncbi Design of a new dental adhesive--effect of a water-soluble sodium acylphosphine oxide with crown ether on adhesion to dental hard tissues
    Kunio Ikemura
    Department of Research and Development, Shofu Inc, 11 Kamitakamatsu cho, Fukuine, Higashiyama ku, Kyoto 605 0983, Japan
    Dent Mater J 28:267-76. 2009
    ..Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-Na = APO-Na) was synthesized in 67.1% yield and identified by 1H NMR...
  36. ncbi Ubiquitous expression of a cloned murine thymopoietin cDNA
    L Theodor
    Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Acta Haematol 97:153-63. 1997
    b>Thymopoietin (TP) was originally isolated as a 5-kD 49-aa protein from bovine thymus and was subsequently observed to affect T-cell differentiation and function. We report here the molecular cloning of a murine TP cDNA...
  37. doi Proteomic profiling of endothelial cells in human lung cancer
    Hye Jeong Park
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    J Proteome Res 7:1138-50. 2008
    ..In an additional experiment in which 16 cancer samples were analyzed by immunohistochemistry, PRDX4, thymopoietin (TMPO), and COPG were confirmed to be abundantly expressed in lung cancer-derived ECs and in cancerous lung ..
  38. doi Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination
    Ivana Gotic
    Department of Medical Biochemistry, Max F Perutz Laboratories, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    Stem Cells 28:480-8. 2010
    Lamina-associated polypeptide 2 alpha (LAP2 alpha) is a nucleoplasmic protein implicated in cell cycle regulation through its interaction with A-type lamins and the retinoblastoma protein...
  39. pmc Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts
    T M Gant
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 144:1083-96. 1999
    Humans express three major splicing isoforms of LAP2, a lamin- and chromatin-binding nuclear protein. LAP2beta and gamma are integral membrane proteins, whereas alpha is intranuclear...
  40. ncbi Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:248-60. 2006
    The High- and Low-Alcohol Preferring (HAP1/LAP1 and HAP2/LAP2) mouse lines were developed by selective breeding for differences in alcohol preference...
  41. pmc The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles
    C Maison
    Department of Basic Sciences, The University of Crete School of Medicine, Heraklion, Greece
    EMBO J 16:4839-50. 1997
    ..The LAP1-lamin B complex is distinct from analogous complexes formed by the 'lamina-associated polypeptide-2' (LAP2), another inner nuclear membrane protein, and includes a protein kinase...
  42. ncbi Trimethylphosphate: a 30-month chronic toxicity/carcinogenicity study in Wistar rats with administration in drinking water
    E M Bomhard
    Department of Toxicology, Carcinogenicity, and Genotoxicity, Bayer AG, Wuppertal, Germany
    Fundam Appl Toxicol 40:75-89. 1997
    Trimethylphosphate (TMPO) was administered to 50 male and 50 female Wistar rats through their drinking water at doses of 0, 1, 10, or 100 mg/kg body weight up to 30 months...
  43. ncbi LEM-Domain proteins: new insights into lamin-interacting proteins
    Nicole Wagner
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Int Rev Cytol 261:1-46. 2007
    ..nuclear membrane and intranuclear proteins, including emerin, MAN1, LEM2, several alternatively spliced isoforms of LAP2, and various uncharacterized proteins in higher eukaryotes as well as the Drosophila-specific proteins otefin and ..
  44. pmc CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases
    Cynthia A Zahnow
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting Blaustein Cancer Research Building, 1650 Orleans St, Baltimore, MD 21231 1000, USA
    Expert Rev Mol Med 11:e12. 2009
    ..Encoded by an intronless gene, C/EBPbeta is expressed as several distinct protein isoforms (LAP1, LAP2, LIP) whose expression is regulated by the differential use of several in-frame translation start sites...
  45. doi Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes
    D W Craig
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Diabet Med 26:1090-8. 2009
    ....
  46. pmc Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin
    Janna Sand-Dejmek
    Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
    Mol Cancer 10:74. 2011
    ..Inhibition of DNA-PK sensitizes cancer cells to cisplatin killing. The goal of this study is to elucidate the mechanism underlying the effects of DNA-PK on cisplatin sensitivity...
  47. pmc Affect-related behaviors in mice selectively bred for high and low voluntary alcohol consumption
    Adem Can
    Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, USA
    Behav Genet 42:313-22. 2012
    ..However, only HAP2 mice spent more time in the center compared to LAP2 mice. In the DLB, there was a slightly higher anxiety-like phenotype in HAP mice...
  48. doi Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells
    Junxia Li
    Department of Medical Genetics, Third Military Medical University, Chongqing, People s Republic of China
    Biochem Biophys Res Commun 446:267-71. 2014
    ..Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through ..
  49. pmc Unique and shared functions of nuclear lamina LEM domain proteins in Drosophila
    Lacy J Barton
    Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, Iowa 52242
    Genetics 197:653-65. 2014
    The nuclear lamina is an extensive protein network that contributes to nuclear structure and function. LEM domain (LAP2, emerin, MAN1 domain, LEM-D) proteins are components of the nuclear lamina, identified by a shared ∼45-amino-acid ..
  50. pmc The CCAAT/enhancer-binding protein beta-2 isoform (CEBPβ-2) upregulates galectin-7 expression in human breast cancer cells
    Carole G Campion
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    PLoS ONE 9:e95087. 2014
    ..We paid particular attention to C/EBPβ-2 (also known as LAP2), the most transcriptionally active of the C/EBPβ isoforms...
  51. pmc Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death
    Michael V Zaragoza
    UC Irvine Cardiogenomics Program, Department of Pediatrics, Division of Genetics and Genomics and Department of Biological Sciences, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 11:e0155421. 2016
    ..357-2A>G, a novel heterozygous splice-site mutation as the primary mutation with rare or novel variants in HCN4, MYBPC3, PKP4, TMPO, TTN, DMPK and KCNJ10 as potential modifiers and a mechanism consistent with haploinsufficiency.
  52. pmc Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite
    Jorge M Santos
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisbon, Portugal
    Proc Natl Acad Sci U S A 113:7183-8. 2016
    ..gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.
  53. pmc Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae
    R J Trumbly
    J Bacteriol 156:36-48. 1983
    ..Mutations affecting a given enzyme belong to a single complementation group. The four genes were symbolized lap1, lap2, lap3, and lap4, and the corresponding enzymes LAPI, LAPII, LAPIII, and LAPIV...
  54. ncbi The effect of myoglobin on the stability of the hydroxyl-radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO), 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) and 1-alpha-phenyl-tert-butyl nitrone (PBN) in the presence of hydrogen peroxide
    D de Bono
    Department of Cardiology, University of Leicester
    Free Radic Res 20:327-32. 1994
    The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 ..
  55. ncbi Function and assembly of nuclear pore complex proteins
    K Bodoor
    Department of Cell Biology and Anatomy, University of Calgary, AB, Canada
    Biochem Cell Biol 77:321-9. 1999
    ..of NPC components (CAN/Nup214, Nup153, POM121, p62 and Tpr) relative to the integral inner nuclear membrane protein LAP2 and the NPC membrane glycoprotein gp210...
  56. ncbi Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel)
    Nicole Wagner
    Division of Electron Microscopy, Biocenter of the University of Wurzburg, Wurzburg, Germany
    Eur J Cell Biol 82:605-16. 2004
    ..in a number of non-related proteins of the inner nuclear membrane including the lamina-associated polypeptides 2 (LAP2), emerin, MAN1 and the Drosophila protein otefin...
  57. ncbi Components of the nuclear envelope and their role in human disease
    Howard J Worman
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, 10th Floor, Room 508, New York, NY 10032, USA
    Novartis Found Symp 264:35-42; discussion 42-50, 227-30. 2005
    ..These include emerin, which is mutated in X-linked Emery-Dreifuss muscular dystrophy, LAP2, MAN1 and LBR...
  58. ncbi Variability and genetic differentiation among Anopheles (Ano.) intermedius Chagas, 1908 and Anopheles (Ano.) mattogrossensis Lutz & Neiva, 1911 (Diptera: Culicidae) from the Brazilian Amazon
    Joselita Maria Mendes dos Santos
    Coordenação de Pesquisas em Ciências da Saúde, Instituto Nacional de Pesquisas da Amazonia, Manaus, AM 69011 970, Brasil
    Mem Inst Oswaldo Cruz 100:531-7. 2005
    ..021). Most analyzed loci showed genotypic frequencies according to Hardy-Weinberg equilibrium, except for LAP1 and LAP2 in An. intermedius, and EST1 and PGM loci in An. mattogrossensis. The genetic distance between these species (D = 0...
  59. pmc RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs
    Gabriel Rinaldi
    Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Mol Biochem Parasitol 167:118-26. 2009
    ..japonicum. The similarities in sequence and exon/intron structure of the two genes, LAP1 and LAP2, suggest that they arose by gene duplication and that this occurred before separation of the mansoni and japonicum ..
  60. pmc Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase
    Sujiet Puthenveetil
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 131:16430-8. 2009
    ..Four rounds of evolution followed by additional rational mutagenesis produced a "LAP2" sequence with a k(cat)/K(m) of 0...
  61. doi Quantitative proteomic identification of host factors involved in the Salmonella typhimurium infection cycle
    Mijke W Vogels
    Department of Biochemistry and Cell Biology, Biochemistry Division, Utrecht University, Utrecht, The Netherlands
    Proteomics 11:4477-91. 2011
    ..Depletion of peroxiredoxin-6 (PRDX6), isoform β-4c of integrin β-4 (ITGB4), isoform 1 of protein lap2 (erbin interacting protein; ERBB2IP), stomatin (STOM) or TBC domain containing protein 10b (TBC1D10B) resulted in ..
  62. pmc LMX1B is part of a transcriptional complex with PSPC1 and PSF
    Elisa J Hoekstra
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e53122. 2013
    ..Furthermore, we identified GRLF1, DHX9, MYO1C, HSP70 and TMPO as potential LMX1B interactors...
  63. doi Purification and Structural Analysis of LEM-Domain Proteins
    Isaline Herrada
    Institute for Integrative Biology of the Cell, CEA, CNRS, Universite Paris Sud, Gif sur Yvette, Paris, France
    Methods Enzymol 569:43-61. 2016
    b>LAP2-emerin-MAN1 (LEM)-domain proteins are modular proteins characterized by the presence of a conserved motif of about 50 residues...
  64. doi High-pressure structural, elastic, and thermodynamic properties of zircon-type HoPO4 and TmPO4
    O Gomis
    Centro de Tecnologias Fisicas, MALTA CONSOLIDER TEAM, Universitat Politècnica de València, 46022 Valencia, Spain
    J Phys Condens Matter 29:095401. 2017
    Zircon-type holmium phosphate (HoPO4) and thulium phosphate (TmPO4) have been studied by single-crystal x-ray diffraction and ab initio calculations...
  65. pmc Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis
    L Yang
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cell Biol 137:1199-210. 1997
    ..compared the localization of two inner nuclear membrane proteins (laminaassociated polypeptides 1 and 2 [LAP1 and LAP2]) and a nuclear pore membrane protein (gp210) to the distribution of bulk ER membranes, which was determined with ..
  66. pmc C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis
    K K Lee
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 11:3089-99. 2000
    Emerin, MAN1, and LAP2 are integral membrane proteins of the vertebrate nuclear envelope. They share a 43-residue N-terminal motif termed the LEM domain...
  67. ncbi Characterization of the major laccase isoenzyme from Trametes pubescens and regulation of its synthesis by metal ions
    Christiane Galhaup
    Division of Biochemical Engineering, Institute of Food Technology, University of Agricultural Sciences Vienna Universität für Bodenkultur Wien, BOKU, Muthgasse 18, A 1190 Wien, Austria
    Microbiology 148:2159-69. 2002
    The major laccase isoenzyme LAP2 secreted by the white-rot basidiomycete Trametes pubescens in response to high copper concentrations was purified to apparent electrophoretic homogeneity using anion-exchange chromatography and gel ..
  68. pmc Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly
    Miriam Segura-Totten
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 158:475-85. 2002
    ..BAF binds directly to LEM (LAP2, emerin, MAN1) domain nuclear membrane proteins, including LAP2 and emerin...
  69. ncbi A cold-adapted extracellular serine proteinase of the yeast Leucosporidium antarcticum
    Marianna Turkiewicz
    Institute of Technical Biochemistry, Technical University of Łódź, ul Stefanowskiego 4 10, 90 924 Łódź, Poland
    Extremophiles 7:435-42. 2003
    An extracellular serine proteinase, lap2, from the psychrophilic antarctic yeast Leucosporidium antarcticum 171 was purified to homogeneity and characterized. The enzyme is a glycoprotein with a molecular mass of 34...
  70. ncbi The latency-associated transcript promoter of pseudorabies virus directs neuron-specific expression in trigeminal ganglia of transgenic mice
    Satoshi Taharaguchi
    Laboratory of Animal Experiment for Disease Model, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    J Gen Virol 84:2015-22. 2003
    ..regulate the PRV LAT promoter in vivo, three transgenic mouse lines containing the PRV LAT promoter (LAP; LAP1 and LAP2) linked to the chloramphenicol acetyltransferase (CAT) gene were generated...
  71. ncbi Histone deacetylase inhibitors--a new tool to treat cancer
    Raz Somech
    Laboratory of Molecular Hemato Oncology, Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel
    Cancer Treat Rev 30:461-72. 2004
    ..laboratory is interested in the transcription repression mechanism induced by the nuclear envelope lamina associated polypeptide 2 (LAP2) family of proteins through chromatin modification...
  72. ncbi The localization of LAP2 beta during pronuclear formation in bovine oocytes after fertilization or activation
    Mamiko Isaji
    Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
    Zygote 14:157-67. 2006
    ..The results also indicate that CH treatment inhibits LAP2beta assembly around oCh but not histone H3 dephosphorylation...
  73. ncbi Acoustic startle at baseline and during acute alcohol withdrawal in replicate mouse lines selectively bred for high or low alcohol preference
    Julia A Chester
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907 2081, USA
    Alcohol Clin Exp Res 31:1633-44. 2007
    ..differences in alcohol preference in 2 mouse lines selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  74. pmc High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task
    B G Oberlin
    Department of Psychology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 33:1294-303. 2009
    ..In this study, we address this question by testing alcohol-naïve mice from lines showing heritable differences in alcohol intake...
  75. pmc Novel phosphotyrosine targets of FGFR2IIIb signaling
    Yongde Luo
    IBT Proteomics and Nanotechnology Laboratory, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77030 3303, USA
    Cell Signal 21:1370-8. 2009
    ..attenuation of cell proliferation, and several factors that maintain nuclear-cytosolic relationships (emerin and LAP2), protein structure and other cellular fine structures as well as some proteins of unknown functions...
  76. doi Overcoming extreme obesity with robotic surgery
    Pamela Stone
    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Int J Med Robot 6:382-5. 2010
    ..As studied in the LAP2, comparable outcomes have been noted in laparotomy vs laparoscopic surgery...
  77. pmc Intragastric self-infusion of ethanol in high- and low-drinking mouse genotypes after passive ethanol exposure
    T L Fidler
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 10:264-75. 2011
    ..intragastric (IG) catheters in mouse genotypes previously shown to drink high (C57BL/6J, HAP2) or low (DBA/2J, LAP2) amounts of ethanol in home-cage continuous-access two-bottle choice procedures...
  78. pmc Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes
    Jeffrey Maranto
    Department of Neuroscience, Temple University School of Medicine, 3500, N Broad Street, Philadelphia, Pennsylvania 19140, USA
    J Cell Biochem 112:1168-75. 2011
    ..in astroglial cells focusing on the role of the upstream kinase MKK6, p38-α MAPK, and C/EBP-β isoforms (LAP1, LAP2, or LIP) in astroglial cells...
  79. pmc LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis
    Huili Li
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cancer 10:100. 2011
    ..factor, CCAAT enhancer binding protein-β (C/EBPβ), is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) that have opposing actions in cellular proliferation and differentiation...
  80. doi Effects of cross-fostering on alcohol preference and correlated responses to selection in high- and low-alcohol-preferring mice
    Gustavo D Barrenha
    Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907 2081, USA
    Alcohol Clin Exp Res 36:2065-73. 2012
    ..of these experiments was to examine the effects of cross-fostering on free-choice alcohol drinking and correlated responses to selection for alcohol preference in mice selectively bred for high (HAP2) and low (LAP2) alcohol preference.
  81. doi Phosphoproteome analysis reveals differences in phosphosite profiles between tumorigenic and non-tumorigenic epithelial cells
    Flavia V Winck
    Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
    J Proteomics 96:67-81. 2014
    ..The identification of phosphorylation sites in tumorigenic cells may contribute to disclose novel signaling mechanisms associated with OSCC...
  82. doi The impact of obesity on surgical staging, complications, and survival with uterine cancer: a Gynecologic Oncology Group LAP2 ancillary data study
    Camille C Gunderson
    University of Oklahoma, Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Oklahoma City, OK, USA Electronic address
    Gynecol Oncol 133:23-7. 2014
    To determine the association of body mass index (BMI) on complications, recurrence, and survival in GOG LAP2, a randomized comparison of laparoscopic versus open staging in clinically early stage uterine cancer (EC).
  83. pmc Cyclin D1 and C/EBPβ LAP1 operate in a common pathway to promote mammary epithelial cell differentiation
    Qiang Liu
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Mol Cell Biol 34:3168-79. 2014
    ..C/EBPβ is an intronless gene encoding three protein isoforms--LAP1, LAP2, and LIP. Here, we provide evidence that cyclin D1 engages C/EBPβ in an isoform-specific manner...
  84. pmc Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability
    Magda Dubińska-Magiera
    Laboratory of Nuclear Proteins, Faculty of Biotechnology, University of Wrocław, Joliot Curie 14a, 50 383, Wrocław, Poland
    Protoplasma 253:943-56. 2016
    Xenopus LAP2β protein is the single isoform expressed in XTC cells. The protein localizes on heterochromatin clusters both at the nuclear envelope and inside a cell nucleus...
  85. pmc Loss of lamin A function increases chromatin dynamics in the nuclear interior
    I Bronshtein
    Physics Department and Nanotechnology Institute, Bar Ilan University, Ramat Gan 5290002, Israel
    Nat Commun 6:8044. 2015
    ..In contrast, depletion of LAP2α, a protein that interacts with lamin A and chromatin, has no such effect on genome dynamics...
  86. pmc Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2
    Ramón Ramos Barrales
    Department of Physiological Chemistry, Biomedical Center, Ludwig Maximilians University of Munich, 82152 Martinsried, Germany
    Genes Dev 30:133-48. 2016
    ..Chromatin association and tethering of centromeres to the periphery are mediated by the N-terminal LEM (LAP2-Emerin-MAN1) domain of Lem2, whereas telomere anchoring and heterochromatin silencing require exclusively its ..
  87. ncbi The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein
    S Manilal
    MRIC Biotechnology Group, N E Wales Institute, UK
    Hum Mol Genet 5:801-8. 1996
    ..results, together with sequence and structural homologies between emerin, thymopoietins and the nuclear lamina-associated protein, LAP2, we suggest that emerin will prove to be one member of a family of inner nuclear membrane proteins.
  88. ncbi Domain-specific disassembly and reassembly of nuclear membranes during mitosis
    B Buendia
    Departement de Biologie Cellulaire, Institut Jacques Monod, CNRS, Paris, France
    Exp Cell Res 230:133-44. 1997
    ..In these studies, protein LAP2/thymopoietin beta, another marker of the inner nuclear membrane, was segregating as lamin B receptor, suggesting that both ..
  89. ncbi Cell cycle dynamics of the nuclear envelope
    Roland Foisner
    Department of Medical Biochemistry, Section of Molecular Cell Biology, Vienna Biocenter, University of Vienna, Dr Bohrgasse 9, A 1030 Vienna, Austria
    ScientificWorldJournal 3:1-20. 2003
    ..Various chromatin-binding domains in lamina proteins, such as the LEM domain, present in all LAP2 isoforms and in emerin, as well as unique regions in lamina proteins and in specific LAP2 isoforms have been ..
  90. ncbi Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma
    Kiyosumi Shibata
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gynecol Oncol 95:307-13. 2004
    ..The objective of this study was to determine whether P-LAP expression affects the chemosensitivity in endometrial carcinoma patients...
  91. ncbi Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina
    YANIRA GONZALEZ
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston, TX USA
    Nucleus 3:60-76. 2012
    ..the Lem2 and Man1 proteins of the fission yeast Schizosaccharomyces pombe, evolutionarily distant relatives of the Lap2/Emerin/Man1 (LEM) sub-family of animal cell lamin-associated proteins, perform fundamental functions of the animal ..
  92. pmc Plant leucine aminopeptidases moonlight as molecular chaperones to alleviate stress-induced damage
    Melissa A Scranton
    Department of Botany and Plant Sciences and Center for Plant Cell Biology, University of California, Riverside, California 92521, USA
    J Biol Chem 287:18408-17. 2012
    ..from heat-induced damage, it was shown that the tomato LAP-A and LAP-N and the Arabidopsis thaliana LAP1 and LAP2 are molecular chaperones...
  93. doi A new function of ROD1 in nonsense-mediated mRNA decay
    T F Brazão
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    FEBS Lett 586:1101-10. 2012
    ..Finally, we show through RIP-seq that ROD1 and UPF1 associate with a significant number of common transcripts...
  94. pmc Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
    Alexandre Chojnowski
    Developmental and Regenerative Biology, Institute of Medical Biology, Singapore, Singapore
    elife 4:. 2015
    ..Here, we describe an inducible cellular system to model HGPS and find that LAP2α (lamina-associated polypeptide-α) interacts with lamin A, while its interaction with progerin is significantly ..
  95. pmc Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype
    Birthe Fahrenkrog
    Institute of Molecular Biology and Medicine, Universite Libre de Bruxelles, Charleroi, Belgium
    PLoS ONE 11:e0152321. 2016
    ..in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2α (LAP2α)...
  96. ncbi Inner nuclear membrane proteins: functions and targeting
    L Holmer
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell Mol Life Sci 58:1741-7. 2001
    ..that reside in the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin...
  97. ncbi Analysis of regulatory functions for the region located upstream from the latency-associated transcript (LAT) promoter of pseudorabies virus in cultured cells
    Satoshi Taharaguchi
    Laboratory of Animal Experiment for Disease Model, Institute for Genetic, Medicine, Hokkaido University, 060 0815, Sapporo, Japan
    Vet Microbiol 85:197-208. 2002
    ..Although two different sequences, LAP1 and LAP2, are thought to be involved in LAT gene expression, the function of the upstream region of the LAT promoter (LAP1 ..
  98. ncbi [Induction of nuclear envelope formation around individual chromosomes under impact of hypotonic shock]
    S Iu Kurchashova
    Department of Electron Microscopy, Research Institute of Physico Chemical Biology after A N Belozersky, Moscow State University
    Tsitologiia 45:298-307. 2003
    ..we have studied the distribution of some proteins participating in the nuclear envelope assembly (lamins A/C, B and LAP2 alpha) in mitotic cells and after hypotonic treatment with 15% Hank's solution...
  99. ncbi Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
    Naoki Yokota
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The University of Toronto, Toronto, Ontario, Canada
    Oncogene 23:3444-53. 2004
    ..Genes found to be upregulated in the murine MB library included cyclin D2 (Ccnd2), thymopoietin (Tmpo), Musashi-1 (Msh1), protein phosphatase 2A inhibitor-2 (I-2pp2a), and Unc5h4(D)...
  100. ncbi Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo
    Veljko Puskovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Mol Ther 10:67-75. 2004
    ..latency-associated transcripts (LATs) in the absence of viral lytic functions, and the latency-associated promoter (LAP2) has been identified as a moveable element responsible for the expression of LATs from latent HSV genomes...
  101. pmc Prolonged regulatable expression of EPO from an HSV vector using the LAP2 promoter element
    Z Wu
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA
    Gene Ther 19:1107-13. 2012
    ..Taken together, these results suggest such a vector is well suited for clinical trial for the treatment of chronic or subacutely developing neuropathy...

Research Grants9

  1. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  2. RICHARD LOWELL BELL; Fiscal Year: 2014
    ..supply to off-campus researchers at cost P/NP, HAD1-2/LAD1-2, and AA/ANA selectively bred rats, as well as HAP1-2-3/LAP2-3 and cHAP selected mice that show genetically high and/or low alcohol preference. (Specific Aims 2 and 3)...
  3. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
    ..ICPO expression (iv) To characterize cis-acting elements associated with two LAT promoters designated LAP1 and LAP2. (v) To determine the role of chromatin and DNA methylation in promoter silencing during latency...
  4. QTL MAPPING FOR ALCOHOL PREFERENCE IN SELECTED MICE
    Paula Bice; Fiscal Year: 2004
    ..We also propose a similar analysis in the second replicate set, (the HAP2/LAP2) line staring in the 2nd generation...
  5. Roles of BAF-Like in the nucleus
    Miriam Segura Totten; Fiscal Year: 2005
    ..To test this hypothesis, we will study the interactions of BAF-L with BAF, LAP2 and MLL3 in vitro and in vivo...
  6. Measuring the Aversive Effects of Alcohol Withdrawal
    JULIA CHESTER; Fiscal Year: 2006
    ..Studies using this place conditioning technique are likely to provide important information that will lead to the development of novel behavioral and pharmacological treatments for alcoholism. ..
  7. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Encoded by an intronless gene, C/EBPB is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) whose expression is tightly regulated by the differential use of a number of in-frame translation start ..
  8. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
    ..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..
  9. Identification of Genes for Alcohol Preference in Noninbred Rats and Mice
    Paula Bice; Fiscal Year: 2009
    ..abstract_text> ..