TMEM129

Summary

Gene Symbol: TMEM129
Description: transmembrane protein 129
Alias: D4S2561E, E3 ubiquitin-protein ligase TM129, RING-type E3 ubiquitin transferase TM129, transmembrane protein 129, E3 ubiquitin protein ligase
Species: human

Top Publications

  1. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
  2. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
  3. pmc A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
    Michael L van de Weijer
    Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Nat Commun 5:3832. 2014
  4. pmc TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
    Dick J H van den Boomen
    Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 111:11425-30. 2014
  5. pmc Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I
    D J H van den Boomen
    Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK Electronic address
    Mol Immunol 68:106-11. 2015
  6. pmc The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein
    Michael L van de Weijer
    Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Viruses 8:. 2016
  7. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010

Scientific Experts

  • Lambertus A Kiemeney
  • Michael L van de Weijer
  • Jonine D Figueroa
  • Nathaniel Rothman
  • Robert Jan Lebbink
  • D J H van den Boomen
  • Emmanuel J H J Wiertz
  • Dick J H van den Boomen
  • Reina Garcia-Closas
  • Alfredo Carrato
  • Victoria K Cortessis
  • Josep Lloreta
  • Eric J Jacobs
  • Xifeng Wu
  • Montserrat Garcia-Closas
  • Olivier Cussenot
  • Consol Serra
  • Robert Grubb
  • Demetrius Albanes
  • Neil Caporaso
  • Amy Hutchinson
  • Debra T Silverman
  • Manolis Kogevinas
  • Zhaoming Wang
  • H Bas Bueno-de-Mesquita
  • Nuria Malats
  • David J Hunter
  • Ludmila Prokunina-Olsson
  • Geraldine Cancel-Tassin
  • Joseph F Fraumeni
  • Nilanjan Chatterjee
  • Malcolm C Pike
  • Simone Benhamou
  • Alan Schned
  • Stephanie J Weinstein
  • W Ryan Diver
  • Paolo Vineis
  • Francoise Clavel-Chapelon
  • Mariana C Stern
  • Manuela Gago-Dominguez
  • William Wheeler
  • Colin P Dinney
  • Elio Riboli
  • Jian Min Yuan
  • David Van Den Berg
  • Margaret R Karagas
  • Stefano Porru
  • Alison Johnson
  • Immaculata De Vivo
  • Dimitrios Trichopoulos
  • Adonina Tardon
  • Jarmo Virtamo
  • Molly Schwenn
  • Susan M Gapstur
  • Borje Ljungberg
  • Amanda Black
  • Gerald Andriole
  • Dalsu Baris
  • Linda J Visser
  • Guus H van Muijlwijk
  • Ana I Costa
  • P J Lehner
  • Angela Carta
  • Vittorio Krogh
  • Giuseppe Mastrangelo
  • Wei Tang
  • David Conti
  • Karla R Armenti
  • H Barton Grossman
  • Paul Brenan
  • Miren Dorronsoro
  • Maria T Landi
  • Jie Lin
  • Eva Comperat
  • Helen R Stagg
  • Morgan Roupret
  • Mark Purdue
  • Jenny Chang-Claude
  • Weronika Patena
  • Paul J Lehner
  • Jennifer Prescott
  • Karsten Skødt
  • Jian Gu
  • James A Nathan
  • Cecilia Arici
  • Richard T Timms
  • Elisabete Weiderpass
  • Constance Chen
  • Seth P Lerner
  • Siyuan Chen

Detail Information

Publications7

  1. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
    ..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC...
  2. pmc Genome-wide association study identifies multiple loci associated with bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hum Mol Genet 23:1387-98. 2014
    ....
  3. pmc A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
    Michael L van de Weijer
    Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Nat Commun 5:3832. 2014
    ..Here using a high-coverage genome-wide shRNA library, we identify the uncharacterized protein TMEM129 and the ubiquitin-conjugating E2 enzyme UBE2J2 to be essential for US11-mediated HLA class I downregulation...
  4. pmc TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I
    Dick J H van den Boomen
    Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 111:11425-30. 2014
    ..In a forward genetic screen for host ERAD components hijacked by US11 in near-haploid KBM7 cells, we identified TMEM129, an uncharacterized polytopic membrane protein...
  5. pmc Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I
    D J H van den Boomen
    Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, UK Electronic address
    Mol Immunol 68:106-11. 2015
    ..US11-mediated degradation is MHC-I-specific and genetic screens have identified TMEM129, an uncharacterised RING-C2 E3 ligase, as responsible for US11-mediated degradation...
  6. pmc The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein
    Michael L van de Weijer
    Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
    Viruses 8:. 2016
    ..Recently, we identified the E3 ubiquitin ligase transmembrane protein 129 (TMEM129) as a key player in this process, where interference with TMEM129 activity in human cells completely abrogates ..
  7. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...