TLR8

Summary

Gene Symbol: TLR8
Description: toll like receptor 8
Alias: CD288, toll-like receptor 8
Species: human

Top Publications

  1. ncbi Three novel mammalian toll-like receptors: gene structure, expression, and evolution
    X Du
    Scripps Research Institute, 10550 N Torrey Pines Road, IMM 31, R204, La Jolla, CA 92037, USA
    Eur Cytokine Netw 11:362-71. 2000
  2. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
  3. ncbi Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms
    Ingel K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Cell Mol Biol 35:387-93. 2006
  4. doi The sweetness of the DNA backbone drives Toll-like receptor 9
    Hermann Wagner
    Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitat Munchen, Trogerstr 30, Munchen, Germany
    Curr Opin Immunol 20:396-400. 2008
  5. pmc Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment
    Denise Richardt-Pargmann
    Pfizer Oligonucleotide Therapeutics Unit OTU, Coley Pharmaceutical GmbH, Merowingerplatz, Dusseldorf, Germany
    Immunobiology 216:12-23. 2011
  6. doi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
  7. doi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
  8. ncbi Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
    Caroline A Jefferies
    Cytokine Research Group, Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 278:26258-64. 2003
  9. doi Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Immunol 139:193-8. 2011
  10. doi Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation
    L Zhou
    Key Laboratory of Organ Transplantation, Zhejiang Province
    Transpl Infect Dis 13:250-8. 2011

Research Grants

  1. Ofer Levy; Fiscal Year: 2016
  2. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
  3. Development of TLR8 inhibitors for treatment of autoimmune diseases
    Cristiana Guiducci; Fiscal Year: 2013
  4. Mark A Atkinson; Fiscal Year: 2016
  5. Screening for Inhibitors of TLR8 for Treatment of Rheumatoid Arthritis
    Robert L Coffman; Fiscal Year: 2013
  6. Juan C Salazar; Fiscal Year: 2015
  7. Yorgo Modis; Fiscal Year: 2015
  8. David B Jacoby; Fiscal Year: 2016
  9. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
  10. Vikki M Abrahams; Fiscal Year: 2015

Detail Information

Publications198 found, 100 shown here

  1. ncbi Three novel mammalian toll-like receptors: gene structure, expression, and evolution
    X Du
    Scripps Research Institute, 10550 N Torrey Pines Road, IMM 31, R204, La Jolla, CA 92037, USA
    Eur Cytokine Netw 11:362-71. 2000
    We describe three novel genes, encoding members of the Toll-like receptor (Tlr) family (TLR7, TLR8, and TLR9). These Tlr family members, unlike others reported to date, were identified within a genomic database...
  2. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA...
  3. ncbi Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms
    Ingel K Demedts
    Department of Respiratory Diseases, Ghent University Hospital 7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Cell Mol Biol 35:387-93. 2006
    ..1 (mDC1) and myeloid dendritic cells type 2 (mDC2) express mRNA transcripts for TLR1, TLR2, TLR3, TLR4, TLR6, and TLR8. Flow cytometric analysis demonstrated high TLR2 protein expression for mDC1 and moderate TLR4 expression for mDC2...
  4. doi The sweetness of the DNA backbone drives Toll-like receptor 9
    Hermann Wagner
    Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitat Munchen, Trogerstr 30, Munchen, Germany
    Curr Opin Immunol 20:396-400. 2008
    ..TLR9 activation sequence-independently as is the case for ds RNA recognizing TLR3 and ss RNA recognizing TLR7 and TLR8. Thus evolutionary pressure might have exiled nucleic acid recognizing TLRs such as TLR9 to endosomes in order to ..
  5. pmc Positive T cell co-stimulation by TLR7/8 ligands is dependent on the cellular environment
    Denise Richardt-Pargmann
    Pfizer Oligonucleotide Therapeutics Unit OTU, Coley Pharmaceutical GmbH, Merowingerplatz, Dusseldorf, Germany
    Immunobiology 216:12-23. 2011
    ..inhibition of T cell proliferation was most prominently seen for TLR7 ligands whereas the effects were minimal for TLR8 and TLR9 ligands indicating that the suppressive phenotype is unique only for certain TLRs...
  6. doi HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells
    Sonja I Gringhuis
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 11:419-26. 2010
    ..Here we show that HIV-1 required signaling by the PRRs Toll-like receptor 8 (TLR8) and DC-SIGN for replication in dendritic cells (DCs)...
  7. doi The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response
    Sally A Nicholas
    Medway School of Pharmacy, University of Kent, Kent ME4 4TB, UK
    Cell Res 19:973-83. 2009
    ..Thus, HIF-1alpha might support both cell survival and the production of pro-inflammatory cytokines upon TLR7/8 activation...
  8. ncbi Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
    Caroline A Jefferies
    Cytokine Research Group, Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 278:26258-64. 2003
    ..Detailed analysis of the interaction between Btk and TLR8 demonstrates that the presence of both Box 2 and 3 motifs in the Toll/interleukin-1 receptor domain was required ..
  9. doi Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke
    David Brea
    Clinical Neuroscience Research Laboratory, Department of Neurology, Hospital Clinico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain
    Clin Immunol 139:193-8. 2011
    ..Infarct volume at 4-7 days was measured on Computed Tomography imaging. TLR7 and TLR8 at different time points were independently associated with poor outcome...
  10. doi Polymorphism in 3'-untranslated region of toll-like receptor 4 gene is associated with protection from hepatitis B virus recurrence after liver transplantation
    L Zhou
    Key Laboratory of Organ Transplantation, Zhejiang Province
    Transpl Infect Dis 13:250-8. 2011
    ..This study focused on the association between polymorphisms in the TLRs and HBV recurrence after liver transplantation in Han Chinese patients...
  11. ncbi The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
    Jianyong Wang
    Department of Pharmacology, 3M Pharmaceutical Division, St Paul, Minnesota 55144, USA
    J Biol Chem 281:37427-34. 2006
    ..The other TLRs that are evolutionarily closely related and highly homologous are TLR7, TLR8, and TLR9...
  12. pmc Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering
    Erika Schlaepfer
    Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland
    PLoS ONE 3:e1999. 2008
    ..In contrast, triggering TLR8 showed a very prominent and overall very consistent effect in PBMC and tonsillar lymphoid suspension cells...
  13. doi Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis
    Christian Enevold
    Institute for Inflammation Research, National University Hospital, Copenhagen, Denmark
    J Rheumatol 37:905-10. 2010
    ..Toll-like receptors (TLR) have been implicated in the pathogenesis of arthritis. We investigated the role of functional variants of TLR in the disease phenotype and severity of rheumatoid arthritis (RA)...
  14. pmc A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
    Navin Rao
    Johnson and Johnson Pharmaceutical Research and Development, 3210 Merryfield Row, San Diego, CA 92121, USA
    Mol Cell Biol 25:6521-32. 2005
    ....
  15. ncbi TLR8 and TLR7 are involved in the host's immune response to human parechovirus 1
    Kathy Triantafilou
    University of Sussex, Infection and Immunity Group, School of Life Sciences, Brighton, UK
    Eur J Immunol 35:2416-23. 2005
    ..In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus...
  16. pmc Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells
    Yu Zhou
    Division of Virology, Wuhan Centers for Disease Control and Prevention, Wuhan, China
    J Neurosci Res 87:2916-25. 2009
    ..Human neuronal cells expressed TLR family members 1-10 and IFN-alpha/beta. The activation of TLR3 or TLR8 by double-stranded RNA (poly-I:C) or single-stranded RNA (ssRNA) induced IFN-alpha/beta expression...
  17. doi TLR activation pathways in HIV-1-exposed seronegative individuals
    Mara Biasin
    Cattedra di Immunologia, Universita degli Studi di Milano, Milan, Italy
    J Immunol 184:2710-7. 2010
    ..ESN individuals showed: 1) comparable percentages of CD14+/TLR4+ and CD4+/TLR8+ CD14+/TLR8+ cells; 2) higher responsiveness to poly I:C, LPS, imiquimod, and ssRNA40 stimulation, associated with ..
  18. ncbi Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    T H Chuang
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037 USA
    Eur Cytokine Netw 11:372-8. 2000
    ..Expression of constitutively active hTLR7-9 stimulates an NF-kappaB signaling pathway indirectly supporting the contention that these receptors are involved in cellular responses to stimuli, which activate innate immunity...
  19. ncbi IFNs activate toll-like receptor gene expression in viral infections
    M Miettinen
    Department of Microbiology, National Public Health Institute, Helsinki, Finland
    Genes Immun 2:349-55. 2001
    ..TLR1, TLR2, TLR4, TLR6, and TLR8 mRNAs were expressed at basal levels in macrophages...
  20. ncbi Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    Marion Jurk
    Nat Immunol 3:499. 2002
  21. ncbi Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
    Katalin Kariko
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Immunity 23:165-75. 2005
    ..We show that RNA signals through human TLR3, TLR7, and TLR8, but incorporation of modified nucleosides m5C, m6A, m5U, s2U, or pseudouridine ablates activity...
  22. ncbi Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    Guangyong Peng
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 309:1380-4. 2005
    ..receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function...
  23. pmc Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Virol 79:12944-51. 2005
    ..RIG-I for activation of an antiviral response, myeloid cells utilized both the single-stranded RNA sensing TLR7 and TLR8 and dsRNA-dependent mechanisms independent of RIG-I, TLR3, and dsRNA-activated protein kinase R to trigger this ..
  24. ncbi Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    Kun Yang
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
    Immunity 23:465-78. 2005
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
  25. ncbi Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling
    Rebecca J Gibbard
    Biochemistry Department, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 281:27503-11. 2006
    ..In this work, we have used site-directed mutagenesis to identify regions of the TLR8 extracellular domain that are required for stimulus-induced signal transduction...
  26. ncbi Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, Washington State, USA
    AIDS 21:441-6. 2007
    ..Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections...
  27. ncbi Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population
    Pei Lin Cheng
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Transl Res 150:311-8. 2007
    ..single nucleotide polymorphisms (SNPs) in TLRs associated with viral infection, including TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9...
  28. doi Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
    Stefan Bauer
    Institut fur Immunology, Philipps Universitat Marburg, BMFZ, Hans Meerweinstr 2, 35043 Marburg, Germany
    Immunobiology 213:315-28. 2008
    ..However, a role in the generation or perpetuation of autoimmune diseases such as systemic lupus erythematosus (SLE) has also been suggested...
  29. doi A functional toll-like receptor 8 variant is associated with HIV disease restriction
    D Y Oh
    Institute of Microbiology and Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Infect Dis 198:701-9. 2008
    Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR8 has been found to recognize RNA derived from various viruses, including human immunodeficiency virus (HIV)...
  30. doi Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders
    S Møller-Larsen
    Institute of Human Genetics, The Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
    Thorax 63:1064-9. 2008
    ..By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained. Xp22 harbours the TLR7 and TLR8 genes.
  31. pmc Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis
    Sonia Davila
    Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore
    PLoS Genet 4:e1000218. 2008
    ..We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous ..
  32. pmc High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females
    Masayuki Saruta
    Inflammatory Bowel Disease Research Center, Cedars Sinai Medical Center and the UCLA School of Medicine, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 15:321-7. 2009
    ..Innate immune defects have been associated with CD, specifically CARD15/NOD2. Recently, Toll-like receptor 8 (TLR8) signaling has been shown to enhance generation of both cytokines...
  33. ncbi Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 181:8002-9. 2008
    ..The key observation that indicated the importance of TLR8 was the inhibition of spontaneous TNF production by imiquimod, which we discovered to be an inhibitor of TLR8...
  34. doi TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation
    Alexandre Larangé
    Universite Paris Sud 11, INSERM UMR S 749, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    J Leukoc Biol 85:673-83. 2009
    ..In particular, the intracellular TLR7 and TLR8, mediating the recognition of ssRNA by DCs, play a major role in the immune response during viral infection...
  35. pmc The heterogeneous allelic repertoire of human toll-like receptor (TLR) genes
    Philippe Georgel
    Laboratoire d Immunogénétique Moléculaire Humaine, Centre de Recherche d Immunologie et d Hématologie, Faculte de Medecine, Universite de Strasbourg, Strasbourg, France
    PLoS ONE 4:e7803. 2009
    ..Hence this work depicts a first overview of the diversity of almost all human TLR genes, a prelude for large-scale population genetics as well as genetic association studies...
  36. pmc Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    Julien Cherfils-Vicini
    Inserm U872, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 120:1285-97. 2010
    ..Here we have demonstrated expression of TLR7 and TLR8, the natural receptors for single-stranded RNA, by tumor cells in human lung cancer in situ and in human lung tumor ..
  37. doi Genetic modulation of TLR8 response following bacterial phagocytosis
    Michael P Gantier
    Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Hum Mutat 31:1069-79. 2010
    Human Toll-like receptors (TLRs) TLR7, TLR8, and TLR9 are important immune sensors of foreign nucleic acids encountered by phagocytes...
  38. doi TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil
    B P dos Santos
    Laboratory of Immunogenetics, Department of Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Lupus 21:302-9. 2012
    ..We analyzed the frequency of TLR7 rs179008, TLR8 rs3764880, TLR9 rs5743836 and rs352140 in 370 patients with SLE and 415 healthy controls from southern Brazil...
  39. doi Toll-like receptors 7, 8, and 9 expression and function in primary human cervical cancer Langerhans cells: evidence of anergy
    Mahesh M Kumar
    Department of Microbiology, Kidwai Memorial Institute of Oncology, Bangalore, India
    Int J Gynecol Cancer 23:184-92. 2013
    ..We explored the status of expression and function of TLR7, TLR8, and TLR9 in primary human Langerhans cells (LCs) isolated from cervical tumors.
  40. doi Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
    Hiromi Tanji
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Science 339:1426-9. 2013
    Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate immune responses...
  41. doi Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes
    Andrea Ablasser
    Institute of Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
    J Immunol 182:6824-33. 2009
    ..In monocytes, the response to RNA oligonucleotides was mediated by either TLR8 or RIG-I...
  42. doi Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss)
    Yniv Palti
    United States Department of Agriculture, Agriculture Research Service, National Center for Cool and Cold Water Aquaculture, Kearneysville, WV 25430, USA
    Dev Comp Immunol 34:219-33. 2010
    ..Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR7 and TLR8 gene orthologs and their mRNA expression...
  43. ncbi Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    Hermann R Bohnenkamp
    Cancer Research UK, Breast Cancer Biology Group, Thomas Guy House, 3rd Floor, Guy s Hospital, London SE1 9RT, UK
    Cell Immunol 247:72-84. 2007
    ..The combination of TLR3 (poly I:C) or TLR4 (LPS) engagement with TLR8 (R848) ligation induced synergistic effects on cytokine production with a boost especially in IL-12p70 secretion...
  44. pmc Investigating Toll-like receptor agonists for potential to treat hepatitis C virus infection
    Amy Thomas
    Discovery Biology IPC424, Pfizer Global Research and Development, Sandwich, Kent, UK
    Antimicrob Agents Chemother 51:2969-78. 2007
    ..Antiviral activity of TLR7 and TLR8 agonists was blocked by an antibody that binds to the type I interferon receptor, confirming that the antiviral ..
  45. doi Synthetic oligoribonucleotides containing arabinonucleotides act as agonists of TLR7 and 8
    Tao Lan
    Idera Pharmaceuticals, Inc, 167 Sidney Street, Cambridge, MA 02139, United States
    Bioorg Med Chem Lett 19:2044-7. 2009
    ..we have synthesized novel SIMRA compounds incorporating arabinonucleotides to study their effects on TLR7 and TLR8 activation...
  46. doi TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells
    Julia Hurst
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Lagenbeckstr 1, 55131 Mainz, Germany
    Immunobiology 214:683-91. 2009
    ..We investigated the induction of IL-1beta production in monocytes and pDCs stimulated with ligands for TLR7 and TLR8 and with antiphospholipid antibodies (aPL)...
  47. doi Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells
    Tsuyoshi Ohkuni
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Toxicol Appl Pharmacol 250:29-38. 2011
    ..HNECs were treated with TLR2 ligand P(3)CSK(4), TLR3 ligand poly(I:C), TLR4 ligand LPS, TLR7/8 ligand CL097, TLR8 ligand ssRNA40/LyoVec, and TLR9 ligand ODN2006...
  48. pmc Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells
    Pamela Osterlund
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Virol 79:9608-17. 2005
    ..IFN-alpha priming led to increased expression of Toll-like receptor 3 (TLR3), TLR7, TLR8, MyD88, TRIF, and IFN regulatory factor 7 (IRF7) genes and enhanced influenza-induced phosphorylation and DNA ..
  49. pmc Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression
    Sampsa Matikainen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Virol 80:3515-22. 2006
    ..TNF-alpha induced the expression of the RIG-I, TLR3, MyD88, TRIF, and IRF7 genes, whereas no detectable TLR7 and TLR8 was seen in A549 cells. TNF-alpha also strongly enhanced IKK epsilon mRNA and protein expression...
  50. doi Expression patterns and functions of toll-like receptors in mouse sertoli cells
    Hui Wu
    Department of Cell Biology, School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, People s Republic of China
    Endocrinology 149:4402-12. 2008
    ..TLR3, TLR4, and TLR5 are highly expressed; TLR6, TLR7, and TLR13 are expressed at relatively low level; and TLR1, TLR8, TLR9, TLR11, and TLR12 are not detected in mouse Sertoli cells...
  51. ncbi Characterization of conserved viral leader RNA sequences that stimulate innate immunity through TLRs
    Alexandra Forsbach
    Coley Pharmaceutical GmbH, Dusseldorf, Germany
    Oligonucleotides 17:405-17. 2007
    ..synthetic oligoribonucleotides encoding such sequences stimulate sequence-dependent cytokine responses via TLR7 and TLR8. Immune cells responding to such sequences include NK cells, NK/T cells, plasmacytoid, and myeloid dendritic cells, ..
  52. pmc Vessel-specific Toll-like receptor profiles in human medium and large arteries
    Olga Pryshchep
    Lowance Center for Human Immunology and Rheumatology, Emory University, School of Medicine, Atlanta, GA 30322, USA
    Circulation 118:1276-84. 2008
    ....
  53. pmc RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    Andrea Ablasser
    Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany
    Nat Immunol 10:1065-72. 2009
    RNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2, Mda5 and RIG-I to trigger antiviral responses. Much less is known about sensors for DNA...
  54. ncbi Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Mol Immunol 40:773-83. 2004
    ..predictions show the presence of one or more counterparts for the human TLR1, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, TLR9, IL-1R and IL-18R genes and one copy of the adaptor genes MyD88, MAL, TRIF and SARM...
  55. doi RBL-2H3 cells are an imprecise model for mast cell mediator release
    Egle Passante
    School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland
    Inflamm Res 58:611-8. 2009
    ..The cell line, RBL-2H3, has been widely used as a mast cell model though much of the data is contradictory. The aim of this study is to assess the RBL-2H3 cell line as an in vitro model for degranulation studies...
  56. ncbi Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand
    Hiroyuki Nagase
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Immunol 171:3977-82. 2003
    ..In contrast, neutrophils expressed a larger variety of TLR mRNAs (TLR1, TLR2, TLR4, TLR6, TLR8 greater than TLR5, TLR9, and TLR10 greater than TLR7)...
  57. doi Differential mRNA expression of Toll-like receptors and their adaptors in pleural effusions
    Liang Che Chang
    Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Keelung, Taiwan, Republic of China
    Respirology 14:1194-9. 2009
    ..The extent of TLR pathway activation may vary with the ligands present in different pleural diseases...
  58. pmc High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors
    Jianzhong Zhu
    Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Immunol 184:5768-76. 2010
    ..Interestingly, they did not show significant effects on TLR3-, TLR7-, and TLR8-mediated NF-kappaB activation...
  59. ncbi The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion
    Michael P Schön
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, Bayerische Julius Maximilians University, Wurzburg, Germany
    J Invest Dermatol 126:1338-47. 2006
    ..It has been demonstrated that this activity is mediated through the Toll-like receptor (TLR)7- and TLR8-signaling cascade resulting in the secretion of proinflammatory cytokines and, consecutively, induction of a tumor-..
  60. ncbi Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy
    Mamoru Satoh
    Second Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan
    Am Heart J 154:581-8. 2007
    ..The purpose of this study was to determine whether TLR8 was expressed with EV replication in patients with enterovirus-associated DCM.
  61. ncbi Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC
    Ella A Zuiderwijk-Sick
    Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Glia 55:1589-600. 2007
    ..Intriguingly, M-CSF-differentiated microglia expressed higher levels of TLR8-encoding mRNA and protein, and produced larger amounts of proinflammatory cytokines in response to TLR8-mediated ..
  62. ncbi Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses
    Shen Ying Zhang
    Laboratory of Human Genetics of Infectious Diseases, Institut National de la Sante et de la Recherche Medicale, Paris, France, EU
    Immunol Rev 220:225-36. 2007
    Five of the 10 human Toll-like receptors (TLRs) (TLR3, TLR4, TLR7, TLR8, and TLR9), and four of the 12 mouse TLRs (TLR3, TLR4, TLR7, TLR9) can trigger interferon (IFN)-alpha, IFN-beta, and IFN-lambda, which are critical for antiviral ..
  63. doi Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8
    Yvonne Döring
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Langenbeckstr 1, 55131 Mainz, Germany
    Immunobiology 215:230-41. 2010
    ..monoclonal aPL resulted in an increased expression and secretion of TNFalpha, caused by specific upregulation of TLR8 mRNA and protein expression levels...
  64. pmc Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
    Jun Wu
    Department of Gastroenterology and Hepatology, University Hospital of Essen, University Duisburg Essen, Essen, Germany
    Immunology 129:363-74. 2010
    ..or interleukin-6 (IL-6), to TLR3 and TLR4 ligands only by producing interferon-beta (IFN-beta), to TLR1 and TLR8 ligands by significantly up-regulating major histocompatibility complex (MHC) class II and costimulatory molecules, ..
  65. doi Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection
    Ivan Mikula
    Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Komenskeho 73, Kosice, Slovakia
    Vet Immunol Immunopathol 138:51-9. 2010
    ..This work presents sequence analysis of ovine TLR7 and TLR8 genes, depicts novel mutations and describes frequencies of mutations in Maedi Visna infected and healthy sheep...
  66. doi Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever
    Aynur Engin
    Department of Infectious Diseases, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey
    Microbes Infect 12:1071-8. 2010
    ..Toll-like receptors (TLRs) are a family of pathogen recognition receptors. TLR8 and TLR9 contribute to the recognition of viruses...
  67. doi CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands
    Joram Buza
    Vaccine and Infectious Disease Organization International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada SK S7N 5E3
    Vet Immunol Immunopathol 126:273-82. 2008
    Single-stranded viral RNA (ssRNA) was recently identified as the natural ligand for TLR7 and TLR8. ssRNA sequences from viruses, as well as their synthetic analogues stimulate innate immune responses in immune cells from humans and mice, ..
  68. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1)...
  69. doi Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8
    Tao Lan
    Idera Pharmaceuticals, Inc, 167 Sidney Street, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 386:443-8. 2009
    ..for their duplex formation, nuclease stability, and ability to induce immune-stimulatory activate through TLR7 and TLR8 in TLR-transfected cell lines, human PBMCs, human pDCs, and in vivo in mice...
  70. doi Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8
    Daqing Wang
    Idera Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Mol Cancer Ther 9:1788-97. 2010
    Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8 (TLR7 and TLR8)...
  71. pmc Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
    Victoria J Philbin
    Division of Immunology and Pathology, Compton Laboratory, Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Immunology 114:507-21. 2005
    Based upon the recognition of antiviral compounds and single stranded viral RNA the Toll-like receptors TLR7 and TLR8 are suggested to play a significant role in initiating antiviral immune responses...
  72. ncbi Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses
    Mouldy Sioud
    The Norwegian Radium Hospital, Department of Immunology, Molecular Medicine Group Montebello, Oslo, Norway
    Eur J Immunol 36:1222-30. 2006
    ..siRNA) sequences stimulate the innate immunity through endosomal Toll-like receptors (TLR), particularly TLR7 and TLR8. However, it remains unclear whether siRNA duplexes act as specific ligands for these receptors...
  73. ncbi RIG-I: tri-ing to discriminate between self and non-self RNA
    Andrew G Bowie
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Trends Immunol 28:147-50. 2007
    ..RNA recognition, these include double stranded (ds)RNA-dependent protein kinase, Toll-like receptor (TLR)3, TLR7, TLR8, retinoic acid-inducible gene (RIG)-I and melanoma differentiation-associated gene 5...
  74. ncbi Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils
    Chun K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Am J Respir Cell Mol Biol 37:85-96. 2007
    ..However, ds poly I-C (TLR3 ligand), LPS (TLR4 ligand), ssRNA (TLR8 ligand), and CpG-DNA (TLR9 ligand) were much less effective or inactive...
  75. doi Vascular cell responsiveness to Toll-like receptor ligands in carotid atheroma
    C Erridge
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Eur J Clin Invest 38:713-20. 2008
    ..However little is known of which PAMPs may be present in atheroma, or capable of stimulating inflammatory signalling in vascular cells...
  76. pmc Microarray analysis of lymphatic tissue reveals stage-specific, gene expression signatures in HIV-1 infection
    Qingsheng Li
    Department of Microbiology, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:1975-82. 2009
    ..g., RIG-1, MDA-5, TLR7 and TLR8, PKR, APOBEC3B, 3F, 3G), adaptive immunity, and in the proapoptotic Fas-Fas ligand pathway...
  77. doi Gene expression analysis during dengue virus infection in HepG2 cells reveals virus control of innate immune response
    Thaís M Conceição
    Programa de Biologia Estrutural, Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Infect 60:65-75. 2010
    ..The present study was focused on the modulation of gene expression in a human hepatic cell lineage, HepG2, in response to Dengue Virus infection...
  78. pmc Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:6442-7. 2010
    ..Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter, we demonstrated that stimulation of TLR8-, but not TLR7-, transfected cells ..
  79. ncbi Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
    Lina Cekaite
    Department of Tumour Biology, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Montebello, 310, Oslo, Norway
    J Mol Biol 365:90-108. 2007
    ..IRF7) were upregulated. Around 90% of the genes (140 out of 160) affected by R-848, a specific ligand for TLR7 and TLR8, were also affected by ss siRNAs or ds siRNAs, indicating that the signaling pathways activated by R-848 are also ..
  80. ncbi IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
    Sinead E Keating
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 282:33435-43. 2007
    ..Knockdown of IRAK-2 expression by small interfering RNA suppressed TLR3, TLR4, and TLR8 signaling to NFkappaB in human cell lines, and importantly, TLR4-mediated chemokine production in primary human ..
  81. ncbi CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
    Yukiko Kiniwa
    Department of Pathology, The Center for Cell and Gene Therapy, Baylor Colleg of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 13:6947-58. 2007
    ..In this study, we investigated prostate tumor-derived CD8(+) Treg cells and their function...
  82. doi Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates
    Chutitorn Ketloy
    Vaccine and Cellular Immunology Laboratory, Chulalongkorn University, Bangkok, Thailand
    Vet Immunol Immunopathol 125:18-30. 2008
    ..In addition, CD40 and CD86 phenotypic responses to TLR8 ligand (poly U) in mo-DCs of macaque were higher than that of human...
  83. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    ..Thus, CD14(dim) cells are bona fide monocytes involved in the innate local surveillance of tissues and the pathogenesis of autoimmune diseases...
  84. doi Recognition of viral single-stranded RNA by Toll-like receptors
    Sandra S Diebold
    King s College London, 2nd Floor Borough Wing, Peter Gorer Department of Immunobiology, Guy s Hospital, London SE1 9RT, United Kingdom
    Adv Drug Deliv Rev 60:813-23. 2008
    ..discusses our current understanding of TLR-mediated recognition of viral single-stranded RNA (ssRNA) by TLR7 and TLR8. Oligoribonucleotides (ORN) and small immune response modifiers such as imidazoquinolines with agonist function ..
  85. doi Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8
    Jianzhong Zhu
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3
    Mol Immunol 46:884-92. 2009
    ..Here we demonstrated that the bovine TLR8 (bTLR8) protein is localized in the ER cellular compartment of transfected cells before and after cell activation...
  86. doi Co-stimulation with TLR7/8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells
    Jayaum S Booth
    Vaccine and Infectious Disease Organization International Vaccine Center, 120 Veterinary Road, University of Saskatchewan, Saskatoon, SK, Canada
    Dev Comp Immunol 34:572-8. 2010
    ..Sheep B cells constitutively expressed TLR7, TLR8 and TLR9 mRNA transcripts, suggesting a possible role of TLR cross-talk in the down-regulatory mechanisms...
  87. ncbi Radiation hybrid mapping of all 10 characterized bovine Toll-like receptors
    K McGuire
    Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK
    Anim Genet 37:47-50. 2006
    ..TLR1, TLR6 and TLR10 map closely together on Bos taurus chromosome 6 (BTA6), while TLR7 and TLR8 map to the X chromosome. TLR2, TLR3, TLR4, TLR5 and TLR9 map to BTA17, BTA27, BTA8, BTA16 and BTA22 respectively...
  88. doi Transcriptional analysis of Toll-like receptors expression in M cells
    Siobhan B Cashman
    Department of Microbiology, University College Cork, Cork, Ireland
    Mol Immunol 47:365-72. 2009
    ..TLR9, which recognises unmethylated CpG DNA of bacteria and viruses and TLR8, which recognises ssRNA, were found to be preferentially expressed in M cells compared to FAE and VE.
  89. ncbi Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling
    Christian Kollewe
    Department of Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    J Biol Chem 279:5227-36. 2004
    ..Thus, IRAK-1 regulates its own availability as an adapter molecule by sequential autophosphorylation...
  90. ncbi Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
    Tadashi Nishiya
    George Williams Hooper Foundation, University of California, Sa Francisco, 94143 0414, USA
    J Biol Chem 279:19008-17. 2004
    ..and the subsequent production of pro-inflammatory cytokines in macrophages expressing TLR4, TLR4/TLR5, or TLR4/TLR8 chimeras but not in macrophages expressing TLR4/TLR1, TLR4/TLR2, or TLR4/TLR6 chimeras...
  91. ncbi Innate immunity at the mucosal surface: role of toll-like receptor 3 and toll-like receptor 9 in cervical epithelial cell responses to microbial pathogens
    Jorunn M Andersen
    Section of Infectious Diseases, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biol Reprod 74:824-31. 2006
    ..that are common in bacterial and some viral nucleic acids, whereas TLR3 recognizes double-stranded RNA and TLR7/TLR8 recognize single-stranded RNA, which would be found during viral replication...
  92. ncbi Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage
    Ivan Perrot
    Laboratory for Immunological Research, Schering Plough, Dardilly, France
    J Immunol 178:2763-9. 2007
    ..blood, CD11c(high) tumor-infiltrating DC (TIDC) displayed a "semi-mature" phenotype, and TLR4 or TLR8 stimulation drove them to mature partially and to secrete limited amounts of cytokines...
  93. ncbi TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages
    Michael P Gantier
    Centre for Cancer Research, Monash Institute of Medical Research, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Immunol 180:2117-24. 2008
    ..Our results suggest that differential sequence-specific sensing of RNA oligonucleotides between human and mouse macrophages is due to the modulation of TLR7 sensing by human TLR8.
  94. pmc Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis
    Athena M Soulika
    Institute for Pediatric Regenerative Medicine, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Neurosci 29:14965-79. 2009
    ..neutrophils and lymphocytes and included intra-axonal accumulations of the endovesicular Toll-like receptor TLR8, and the inflammasome protein NAcht leucine-rich repeat protein 1 (NALP1)...
  95. ncbi Recognition of nucleic acids by Toll-like receptors and development of immunomodulatory drugs
    A Kuznik
    Department of Biotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
    Curr Med Chem 17:1899-914. 2010
    Microbial as well as endogenous nucleic acids are recognized by a group of endosomal Toll-like receptors TLR3, TLR7, TLR8 and TLR9...
  96. doi Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells
    Charlotte Primard
    Institut de Biologie et Chimie des Proteines, UMR5086 CNRS, University of Lyon 1, Lyon, France
    Biomaterials 31:6060-8. 2010
    ..Furthermore, we could document that DCs engulfing some nanoparticles could exhibit a TLR8+ specific expression...
  97. doi Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression
    Warisara Parichatikanond
    Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Int Immunopharmacol 10:1361-73. 2010
    ..TNF, TNFRSF6, and IL1A), chemokines (CCL8 and CXCL11), JAK/STAT signaling (JAK3 and STAT5A), TLRs family (TLR4 and TLR8) and NF-κB (NFKB1). Expression of some genes was validated using RT-PCR...
  98. pmc Decreased Toll-like receptor 8 expression and lower TNF-α synthesis in infants with acute RSV infection
    Kreso Bendelja
    Department of Cellular Immunology, Institute of Immunology, Zagreb, Croatia
    Respir Res 11:143. 2010
    ..The reason could be inadequate multiple TLRs engagement, including TLR8 in recognition of single-stranded viral RNA and diminished synthesis of inflammatory mediators due to a lower ..
  99. pmc Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells
    Rachel L Redfern
    University of Houston, College of Optometry, 505 J Davis Armistead Building, 4901 Calhoun Road, Houston, TX 77204 2020, USA
    Exp Eye Res 92:209-20. 2011
    ..b>TLR8 mRNA was not expressed by any of the samples tested...
  100. pmc Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways
    Victoria J Philbin
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston, Boston, Mass Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 130:195-204.e9. 2012
    ..b>TLR8 agonists, including imidazoquinolines (IMQs), such as the small synthetic 3M-002, induce adult-level TNF from ..

Research Grants33

  1. Ofer Levy; Fiscal Year: 2016
    ..In Aim 3, we will characterize enhancing effects of Ado-refractory adjuvants, TLR8 agonists and ADA, on Ag-specific neonatal vaccine responses in vitro...
  2. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
    ..the investigator's laboratory suggests that the TLR2-independent responses are MyD88-dependent and occur via TLR8. Although intracellular bacterial pathogens have a well recognized ability to induce type I IFNs, they usually have ..
  3. Development of TLR8 inhibitors for treatment of autoimmune diseases
    Cristiana Guiducci; Fiscal Year: 2013
    ..The major exception has been TLR8, despite its ability to stimulate important inflammatory cytokines such as IL6 and TNF-1, and its expression by ..
  4. Mark A Atkinson; Fiscal Year: 2016
    ..of this P01 is to elucidate the mechanisms by which genes;IFIH1,TYK2 (investigated in Project 1) and IL18RAP, TLR8 (Project 2) impart immunoregulatory abnormalities that result in aberrant iNKT development, inflammatory antigen ..
  5. Screening for Inhibitors of TLR8 for Treatment of Rheumatoid Arthritis
    Robert L Coffman; Fiscal Year: 2013
    ..One of the innate receptors for RNA, TLR8, is a potent stimulator of inflammatory cytokines such as IL6 and TNF-[unreadable], and its expression by multiple ..
  6. Juan C Salazar; Fiscal Year: 2015
    ..evidence the TLR2-independent signaling events elicited by Bb in human monocytes are MyD88-dependent and occur via TLR8. On the basis of our collective findings we now propose a new model of Bb-induced monocyte activation, which ..
  7. Yorgo Modis; Fiscal Year: 2015
    ..Viral RNA is recognized by!TLR3, TLR7 and TLR8, and microbial DNA is recognized by TLR9...
  8. David B Jacoby; Fiscal Year: 2016
    ..dependent broncho-dilation in guinea pigs and in human airways is mediated by production of nitric oxide, while TLR8 dependent broncho-dilation is not...
  9. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..We have also shown that in human airways, stimulation of the other ssRNA receptor, TLR8, also causes bronchodilation, but that this pathway does not involve nitric oxide...
  10. Vikki M Abrahams; Fiscal Year: 2015
    ..In our published studies we found TLR2 activation by gram-positive bacterial peptidoglycan (PDG), and TLR8 activation by viral ssRNA, trigger human first trimester trophoblast apoptosis via two distinct pathways: TLR2 ..
  11. T cell regulation: CD4+CD25+ FOXP3+ T cells in acute and chronic HIV-1 infection
    Marylyn Martina Addo; Fiscal Year: 2010
    ..Investigation of the impact of HIV-1-encoded TLR8 ligands on the function of regulatory T cells...
  12. Activators and repressors of NFkappaB and IRF3/7 in innate immunity
    GEORGE ROBERT STARK; Fiscal Year: 2012
    ..and negative regulators of pathways that activate NF-kB, IRF7 and IRF3 in response to Toll-like receptor 8 (TLR8) and TLR3, using genetic selections that their labs have already established...
  13. Chaim O Jacob; Fiscal Year: 2014
    ..We propose to identify the causal variants in the following new genes: FAIM, IRAK1, KLRG1, TNFSF4, TLR8 and SELP by fine mapping, re-sequencing and re-evaluation of the new SNPs identified through sequencing in case-..
  14. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..These PRRs, which include both TLRs (TLR3, TLR7, TLR8 and TLR9) and cytoplasmic RNA helicases (RIG-I, Mda-5 and possibly others) are capable of detecting viral nucleic ..
  15. Dissecting the role of Tollo signaling in synaptic development in Drosophila
    Shannon L Ballard; Fiscal Year: 2012
    ..studies, I have discovered that Tollo, a member of the Toll family of receptors, which is orthologous to vertebrate TLR8, is a positive regulator of NMJ growth and development...
  16. Enhancing Immunotherapy through Toll Like Receptors
    Cynthia Leifer; Fiscal Year: 2007
    ..are not expressed at the cell surface and that they recognize nucleic acids such as dsRNA (TLR3), ssRNA (TLR7 and TLR8) and CpG containing DNA (TLR9)...
  17. Role of the Innate Immune System in the Pathogenesis of HIV-1
    Stephan Krutzik; Fiscal Year: 2007
    ..immunological role of two pattern recognition receptors involved in the detection of HIV-1, Toll-like receptor 8 (TLR8), which recognizes HIV-1 ssRNA, and the C- type lectin CD209 (aka DC-SIGN)...
  18. MUCOSAL IMMUNOSTIMULANTS FOR BIODEFENSE
    Dennis Carson; Fiscal Year: 2005
    ..In some cases, the TLR ligands will be combined with either a macrophage-targeted activator of TLR8, and/or with synthetic inhibitors of inosine monophosphate dehydrogenase (IMPDH), which have been shown in ..
  19. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  20. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  21. Adenosine Shapes Neonatal Toll-like Receptor Function
    Ofer Levy; Fiscal Year: 2010
    ..As a whole, these studies will deepen our understanding of how the unique physiology of the human newborn fundamentally alters innate immunity at birth. ..
  22. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  23. Determinants of Innate Immunity to Group B Streptococci
    Ofer Levy; Fiscal Year: 2005
    ..abstract_text> ..
  24. Novel Leads for the Therapy of Gram-Positive Sepsis
    Sunil David; Fiscal Year: 2004
    ..This is to demonstrate that inhibition of cytokine release, if observed, is attributable to the blockade of the cellular recognition of lipoteichoic acid. ..
  25. Hydrophobic Polyamine Amides as Anti-Endotoxin Agents
    Sunil David; Fiscal Year: 2007
    ..The toxicity of the compounds will be systematically determined in a panel of in vitro assays. These studies will serve to generate data for anticipated IND submissions. [unreadable] [unreadable]..
  26. Gram-Negative Sepsis: Pharmacophore-Based Therapeutics
    Sunil David; Fiscal Year: 2007
    ..abstract_text> ..
  27. Rational Development of Endotoxin Sequestering Agents
    Sunil David; Fiscal Year: 2006
    ..Highly active molecules will be further tested in two murine models of gram-negative sepsis. The toxicity of the compounds will be systematically determined in a panel of in vitro assays. ..
  28. Novel High-throghput Assay:Angiogenesis Inhibitors (RMI)
    Sunil David; Fiscal Year: 2004
    ..Promising compounds will be examined in greater detail with respect to details of the physical interactions with heparin. Further biological activity will be ascertained in chicken chorioallantoic membrane assays. ..
  29. Heat Shock Proteins and Helicobacter Pylori Pathogenesis
    Evelyn Kurt Jones; Fiscal Year: 2006
    ..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..
  30. CARDIOMYOPATHY, HIV1 AND CHEMOKINES
    Milan Fiala; Fiscal Year: 2001
    ..The results of this research could lead to development of new strategies for preventing or ameliorating the effects of HIV infection on the heart. ..
  31. COCAINE AND HIV1 IN CORONARY ENDOTHELIUM
    Milan Fiala; Fiscal Year: 2002
    ..abstract_text> ..
  32. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..