TLR3

Summary

Gene Symbol: TLR3
Description: toll like receptor 3
Alias: CD283, IIAE2, toll-like receptor 3
Species: human

Top Publications

  1. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
  2. pmc Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
    Yuping Lai
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Nat Med 15:1377-82. 2009
  3. ncbi RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 5:503-7. 2004
  4. pmc The molecular structure of the Toll-like receptor 3 ligand-binding domain
    Jessica K Bell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:10976-80. 2005
  5. doi Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines
    A Tournadre
    University of Lyon, Edouard Herriot Hospital, Lyon, France
    Arthritis Rheum 62:2144-51. 2010
  6. doi Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity
    Peng Zhou
    Department of Ophthalmology, Peking University People s Hospital, No 11 South Ave of XiZhiMen, Xicheng District, Beijing, 100044, People s Republic of China
    FASEB J 25:3489-95. 2011
  7. pmc Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells
    Nan Wang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Virol 83:9824-34. 2009
  8. doi Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells
    Nanae Harashima
    Department of Immunology, Shimane University, Izumo, Shimane, Japan
    Cancer Immunol Immunother 61:667-76. 2012
  9. pmc Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis
    Mattias Fransson
    Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 6:100. 2005
  10. ncbi Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    Loic Guillot
    Unité de Défense Innée et Inflammation, INSERM E336, Paris, France
    J Biol Chem 280:5571-80. 2005

Research Grants

  1. ROBERT A LAFYATIS; Fiscal Year: 2015
  2. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
  3. Martin E Dorf; Fiscal Year: 2015
  4. Cell-based assay for high-throughput screening of TLR3 activators
    Tsung Hsien Chuang; Fiscal Year: 2010
  5. Maximizing Memory T Cell Responses by Matured Post Chemotherapy Dendritic Cells
    Mark P Rubinstein; Fiscal Year: 2012
  6. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
  7. Mechanisms of Immunosuppressive Actions of Glucocorticoids
    Inez Rogatsky; Fiscal Year: 2011
  8. Demetrios Vavvas; Fiscal Year: 2014
  9. Inflammatory and Chemotactic Cytokines in Bronchopulmonary Dysplasia
    Vedang A Londhe; Fiscal Year: 2011
  10. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-beta production...
  2. pmc Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
    Yuping Lai
    Division of Dermatology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Nat Med 15:1377-82. 2009
    ..staphylococcal lipoteichoic acid (LTA) and acts selectively on keratinocytes triggered through Toll-like receptor 3(TLR3)...
  3. ncbi RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 5:503-7. 2004
    ..Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by the TLR3 ligand double-stranded RNA is Trif ..
  4. pmc The molecular structure of the Toll-like receptor 3 ligand-binding domain
    Jessica K Bell
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:10976-80. 2005
    ..In this study, we have expressed and crystallized the ectodomain (ECD) of human TLR3, which recognizes dsRNA, a molecular signature of viruses, and have determined the molecular structure to 2...
  5. doi Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines
    A Tournadre
    University of Lyon, Edouard Herriot Hospital, Lyon, France
    Arthritis Rheum 62:2144-51. 2010
    ..To assess the expression of Toll-like receptor 3 (TLR-3) and TLR-7 in muscle tissue from patients with polymyositis (PM) and dermatomyositis (DM) and to investigate the function and regulation of TLR-3 in cultured muscle cells...
  6. doi Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity
    Peng Zhou
    Department of Ophthalmology, Peking University People s Hospital, No 11 South Ave of XiZhiMen, Xicheng District, Beijing, 100044, People s Republic of China
    FASEB J 25:3489-95. 2011
    The genetic association between a variant in the Toll-like receptor 3 (TLR3) gene (C1234T in mRNA, L412F in protein, Reference SNP Cluster Report rs3775291) and geographic atrophy (GA; also called advanced "dry" age-related macular ..
  7. pmc Toll-like receptor 3 mediates establishment of an antiviral state against hepatitis C virus in hepatoma cells
    Nan Wang
    Center for Hepatitis Research, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Virol 83:9824-34. 2009
    Toll-like receptor-3 (TLR3) senses double-stranded RNA, initiating signaling that activates NF-kappaB and interferon regulatory factor 3 (IRF-3), thereby inducing the synthesis of proinflammatory cytokines, type I interferons, and ..
  8. doi Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells
    Nanae Harashima
    Department of Immunology, Shimane University, Izumo, Shimane, Japan
    Cancer Immunol Immunother 61:667-76. 2012
    ..In the present study, we analyzed the effects of polyinosinic-polycytidylic acid [poly(I:C)], a TLR3 ligand, on three TLR3-expressing human prostate cancer cell lines (LNCaP, PC3, and DU145)...
  9. pmc Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis
    Mattias Fransson
    Department of Oto Rhino Laryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Respir Res 6:100. 2005
    ..The present study was designed to examine the expression of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with intermittent allergic rhinitis, focusing on changes induced by exposure to pollen...
  10. ncbi Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    Loic Guillot
    Unité de Défense Innée et Inflammation, INSERM E336, Paris, France
    J Biol Chem 280:5571-80. 2005
    ..We established that TLR3 is constitutively expressed in human alveolar and bronchial epithelial cells, and we describe its intracellular ..
  11. doi Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells
    Kok Hooi Yew
    Pediatric Infectious Disease, Children s Mercy Hospitals, Kansas City, MO, United States
    Mol Immunol 47:883-93. 2010
    ..These findings reveal a novel mechanistic insight into an interrelationship between SR-A1 and TLR-3/-9 signaling in HCMV-exposed monocytes...
  12. pmc Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
    Sandeep K Agarwal
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, 6431 Fannin Avenue, Houston, TX 77030, USA
    Arthritis Res Ther 13:R3. 2011
    ..Therefore, we investigated the regulation of TLR expression on dermal fibroblasts by IFN...
  13. doi TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
    F A Castro
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Eur J Cancer 47:1203-10. 2011
    ..Although molecular markers have been suggested for follow up of treated CRC patients, their complete clinical application is still under evaluation...
  14. doi Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
    Takanori Numata
    Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105 8461, Japan
    J Immunol 187:510-9. 2011
    b>TLR3, one of the TLRs involved in the recognition of infectious pathogens for innate and adaptive immunity, primarily recognizes viral-associated dsRNA...
  15. pmc Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects)
    Cordula Weber
    Pfizer Oligonucleotide Therapeutics Unit Coley Pharmaceutical GmbH, Merowingerplatz 1a, 40225 Dusseldorf, Germany
    Immunology 136:64-77. 2012
    ..b>TLR3 is located on the cell surface and in cellular endosomes and recognizes double-stranded viral RNA or the synthetic ..
  16. ncbi Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..b>TLR3 was only expressed in human dendritic cells (DC) wherein maturation induced by bacterial products or cytokines was ..
  17. ncbi Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA
    Kenji Funami
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Immunol 179:6867-72. 2007
    b>TLR3 recognizes viral dsRNA and induces antiviral immune responses...
  18. pmc Unexpected protective role for Toll-like receptor 3 in the arterial wall
    Jennifer E Cole
    Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London W6 8LH, United Kingdom
    Proc Natl Acad Sci U S A 108:2372-7. 2011
    ..Using human and murine systems, we have investigated the consequence of TLR3 signaling in vascular disease...
  19. pmc Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 205:1967-73. 2008
    ..a Toll/IL-1R domain-containing adaptor-inducing interferon-beta-dependent signaling pathway that is initiated by TLR3 and TLR4, respectively...
  20. pmc A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection
    Elin Kindberg
    Division of Molecular Virology, Medical Faculty, University of Linkoping, Linkoping, Sweden
    J Infect Dis 203:523-8. 2011
    ..A mutation in the chemokine receptor 5 gene has been associated with increased risk of TBE but explains only a limited number of cases. Investigations of further risk factors are needed...
  21. doi Association between a functional polymorphism in Toll-like receptor 3 and chronic hepatitis C in liver transplant recipients
    S O Lee
    Division of Infectious Diseases, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Transpl Infect Dis 15:111-9. 2013
    Toll-like receptor 3 (TLR3) is implicated in the pathogenesis of viral diseases owing to its ability to recognize viral double-stranded RNA...
  22. pmc Toll-like receptor 3 expression in glia and neurons alters in response to white matter injury in preterm infants
    R Vontell
    Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, King s College London St Thomas Hospital, London, UK
    Dev Neurosci 35:130-9. 2013
    ..This study investigated cellular expression of TLR3 using immunohistochemistry on human brain tissue...
  23. ncbi Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems
    Anna M Lundberg
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, 1 Aspenlea Road, Hammersmith, London, United Kingdom
    Blood 110:3245-52. 2007
    b>TLR3 recognizes double-stranded RNA, a product associated with viral infections. Many details of TLR3-induced mechanisms have emerged from gene-targeted mice or inhibition studies in transformed cell lines...
  24. doi TLR3: interferon induction by double-stranded RNA including poly(I:C)
    Misako Matsumoto
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Adv Drug Deliv Rev 60:805-12. 2008
    Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)) and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic ..
  25. pmc Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells
    Akira Koarai
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Am J Respir Cell Mol Biol 42:651-60. 2010
    ..Recently, Toll-like receptor 3 (TLR3) has been demonstrated to react to double-stranded RNA (dsRNA) and to be involved in the immune responses after ..
  26. doi TLR3 ligation protects human astrocytes against oxidative stress
    E Borysiewicz
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 1 Medical Center Dr, Morgantown, WV 26506, USA
    J Neuroimmunol 255:54-9. 2013
    Astrocytic Toll-like receptor 3 (TLR3) plays an important role not only in antiviral response but also in regeneration/healing of the CNS...
  27. ncbi SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes
    Xiuju Dai
    Department of Dermatology, Ehime University School of Medicine, Toon City, Ehime, Japan
    J Invest Dermatol 126:1574-81. 2006
    ..Epidermal keratinocytes express TLR3 and provide an innate immune defense against viral infection...
  28. ncbi Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells
    Hirotaka Morishima
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara Hospital, Sagamihara, Japan
    Int Arch Allergy Immunol 145:163-74. 2008
    Viral infection causes asthma exacerbations and airway hyperreactivity. Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) of viral or synthetic origin in a fashion different from protein kinase R (PKR)...
  29. doi Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells
    E Nakada
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver V6Z 1Y6, Canada
    Placenta 30:774-9. 2009
    ..Therefore, we tested the hypothesis that TLR stimulation of a trophoblast cell line induces inflammatory mediator production and, in particular, production of the preeclampsia-related anti-angiogenic factor sFLT-1...
  30. doi Toll-like receptor 3 has no critical role during early immune response of human monocyte-derived dendritic cells after infection with the human cytomegalovirus strain TB40E
    Markus Mezger
    Julius Maximilians Universitat Wurzburg, Medizinische Klinik and Poliklinik II, Eberhard Karls Universität Tuebingen, Tubingen, Germany
    Viral Immunol 22:343-51. 2009
    ..Here, the role of TLR3 in the interaction of monocyte-derived dendritic cells (moDCs) with human cytomegalovirus (HCMV) was investigated ..
  31. pmc Inhibition of DC-SIGN-mediated transmission of human immunodeficiency virus type 1 by Toll-like receptor 3 signalling in breast milk macrophages
    Yukie Yagi
    Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan
    Immunology 130:597-607. 2010
    ..As for the expression of Toll-like receptors (TLRs) in BrMMø, TLR3 was always seen in BrMMø but not in peripheral blood monocytes (PBMo)...
  32. doi The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients
    Ebru Onalan Etem
    Medical Biology and Genetic Department, Firat University Hospital, Firat University, Elazig, Turkey
    Rheumatol Int 31:1369-74. 2011
    ..This study was conducted to investigate the frequencies of TLR3 rs3775290, TLR9 rs187084, and TLR10 rs4129009 polymorphisms and to detect between polymorphisms and autoantibody ..
  33. pmc TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA
    Ivan Perrot
    Innate Pharma, Marseille, France
    J Immunol 185:2080-8. 2010
    ..two dsRNAs, polyadenylic-polyuridylic acid and polyinosinic-polycytidylic acid [poly(I:C)], similarly engaged human TLR3, whereas only poly(I:C) triggered human RIG-I and MDA5...
  34. doi Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes
    Siamak Djafarzadeh
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland
    Mitochondrion 11:83-8. 2011
    Several studies have shown the presence of liver mitochondrial dysfunction during sepsis. TLR3 recognizes viral double-stranded RNA and host endogenous cellular mRNA released from damaged cells...
  35. doi Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility
    Saumya Pandey
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Mol Biol Rep 38:4715-21. 2011
    ....
  36. pmc Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL)
    Susan Carpenter
    School of Biochemistry and Immunology and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 286:38795-804. 2011
    ..We now show that TRIL also plays a role in TLR3 signaling. TRIL is expressed intracellularly in the astrocytoma cell line U373 and in the monocytic cell line THP1...
  37. pmc Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells
    Manabu Taura
    Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Mol Cell Biol 32:1581-90. 2012
    ..Here, we show that the tumor suppressor retinoblastoma (Rb) protein positively regulates Toll-like receptor 3 (TLR3) expression, the sensing receptor for viral double-stranded RNA and poly(I · C)...
  38. doi Toll-like receptor 3 ligand polyinosinic:polycytidylic acid promotes wound healing in human and murine skin
    Qing Lin
    The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    J Invest Dermatol 132:2085-92. 2012
    ..Our previous study showed that wound healing was impaired in TLR3-deficient mice...
  39. doi Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    Sanna M Mäkelä
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Leukoc Biol 85:664-72. 2009
    ..Stimulation of moDCs with the TLR8 ligand together with the TLR3 or TLR4 ligand led to synergistic IL-6, IL-10, IL-12, and TNF-alpha mRNA expression and cytokine production...
  40. ncbi Species-specific regulation of Toll-like receptor 3 genes in men and mice
    Sven Heinz
    Department of Hematology and Oncology, University of Regensburg, 93042 Regensburg, Germany
    J Biol Chem 278:21502-9. 2003
    Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections...
  41. ncbi Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J and Lucille A Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 176:1733-40. 2006
    ..A replication intermediate of RSV is dsRNA. This is an important ligand for both the innate immune receptor, TLR3, and protein kinase R (PKR)...
  42. doi Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis
    Caroline Ospelt
    Center of Experimental Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Arthritis Rheum 58:3684-92. 2008
    ....
  43. doi Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes
    Youngae Lee
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
    Exp Dermatol 19:e44-9. 2010
    ..mRNA and protein expressions of MMP-1 and MMP-9 in human epidermal keratinocytes are induced by ligands for TLR2, TLR3 and TLR5 [Pam3CSK4, Poly(I:C) and flagellin, respectively] in a dose-dependent manner...
  44. pmc Baculovirus transduction of mesenchymal stem cells triggers the toll-like receptor 3 pathway
    Guan Yu Chen
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
    J Virol 83:10548-56. 2009
    ..Surprisingly, Toll-like receptor-3 (TLR3), a receptor that generally recognizes double-stranded RNA, was apparently upregulated by BV transduction, as ..
  45. doi Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9
    Ning Yu
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, PR China
    J Dermatol Sci 56:113-20. 2009
    ..However, the mechanisms of recognition of microbes by melanocytes have not yet been fully established...
  46. pmc Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals
    Samuel O Pine
    Program in Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, USA
    AIDS 23:2387-95. 2009
    ..We investigated the impact of TLR single nucleotide polymorphisms (SNPs) on clinical outcome in a seroincident cohort of HIV-1-infected volunteers...
  47. doi Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers
    Kyung Ho Lee
    Department of Dermatology, College of Medicine, The Catholic University of Korea, Bucheon, Korea Departments of Microbiology, School of Medicine, Ewha Womans University, Seoul, Korea Department of Dermatology, College of Medicine, The Catholic University of Korea, Uijeongbu St Mary s Hospital, Uijeongbu, Korea
    Exp Dermatol 20:149-51. 2011
    ..Additionally, TSLP expression is increased in filaggrin knockdown as well as TLR3 stimulation in reconstituted human epidermal layers...
  48. pmc A TRIF-independent branch of TLR3 signaling
    Michifumi Yamashita
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 188:2825-33. 2012
    dsRNA is a common pathogen-associated molecular pattern that is recognized by cellular TLR3 and used by virus-infected cells to activate specific transcription factors and trigger induction of antiviral genes...
  49. pmc Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Virol 81:9838-50. 2007
    ..Here we show that the Toll-like receptor 3 (TLR3) ligand poly(I:C) (PIC) induces the expression of IDO in human astrocytes...
  50. doi A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
    Nina Pirher
    Department of Biotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
    Nat Struct Mol Biol 15:761-3. 2008
    We show that substrate specificity of Toll-like receptor 3 (TLR3) is due to the presence of two binding sites in the ectodomain, separated by 50 A...
  51. doi Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis
    Yoshito Ishizaki
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Neurovirol 14:486-91. 2008
    ..MV-derived double-stranded RNA is recognized by toll-like receptor 3 (TLR3), retinoic acid-inducible protein I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5)...
  52. doi Expression of toll-like receptors 2 and 3 on esophageal epithelial cell lines and on eosinophils during esophagitis
    Daniel J Mulder
    Department of Anatomy and Cell Biology, Gastrointestinal Diseases Research Unit, Queen s University, Kingston, ON, Canada
    Dig Dis Sci 57:630-42. 2012
    ..Activation of toll-like receptors (TLRs) in other tissues is known to initiate eosinophil infiltration, thus TLRs may be a potential mediator of esophageal eosinophilia. Little is known about TLRs in the esophagus...
  53. pmc Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization
    Rongsu Qi
    Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47401, USA
    J Biol Chem 287:32617-29. 2012
    ..Whether TLR3 requires similar proteolytic processing to become competent for signaling remains unclear...
  54. pmc Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles
    Andrew W Borkowski
    Division of Dermatology, University of California, San Diego, San Diego, California 92093 0869, USA
    J Invest Dermatol 133:2031-40. 2013
    ..RNA (dsRNA) from necrotic keratinocytes, has been identified as an endogenous activator of Toll-like receptor 3 (TLR3)...
  55. pmc Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2
    A E Østvik
    Centre of Molecular Inflammation Research, Department of Cancer Research, Norwegian University of Science and Technology, Trondheim, Norway
    Clin Exp Immunol 173:502-11. 2013
    ....
  56. ncbi Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
    Claudia Wietek
    Department of Biochemistry, Trinity College, Dublin, Ireland
    J Biol Chem 278:50923-31. 2003
    ..factor that binds the interferon-sensitive response element (ISRE) and is activated by Toll-like receptor 3 (TLR3) and TLR4...
  57. doi Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects
    Chelvin C A Sng
    Singapore Eye Research Institute, National University of Singapore, Singapore
    Ophthalmic Res 45:191-6. 2011
    ..A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations...
  58. doi Expression of toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia
    Antonio Pineda
    Unidad de Medicina Familiar, Instituto Mexicano de Seguro Social, Estado de Mexico
    Arch Med Res 42:382-91. 2011
    ..We undertook this study to determine if there are changes in the expression and localization of TLR-2, TLR-4, TLR-3 and TLR-9 in preeclamptic term placentas as compared with normal placentas...
  59. doi Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts
    Bo Wang
    Department of Obstetrics and Gynecology, University of Tokyo, 7 3 1 Hongo Bunkyo Tokyo, 113 8655, Japan
    Endocrinology 152:4984-92. 2011
    ..These findings suggest that upon viral infection, trophoblasts induce IDO and in turn contribute to antimicrobial activity and maintenance of fetomaternal tolerance...
  60. ncbi Blockade of Lyn kinase upregulates both canonical and non-canonical TLR-3 pathways in THP-1 monocytes exposed to human cytomegalovirus
    K H Yew
    Children s Mercy Hospitals, Kansas City, MO, USA
    Acta Virol 55:243-53. 2011
    ..Thus, the observed shift away from TNF-α to robust IFN-β and IL-12p35 induction may offer opportunities for therapeutic interventions...
  61. pmc Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3
    YVONNE LAI
    Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 6:e25837. 2011
    Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses...
  62. pmc Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1
    Jakub Siednienko
    Institute of Immunology, National University of Ireland Maynooth, County Kildare, Ireland
    J Biol Chem 286:44750-63. 2011
    ..examined the role of NF-κB in regulating IFN-β expression in response to the viral-sensing Toll-like receptor 3 (TLR3)...
  63. pmc Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling
    Alejandra Garcia-Cattaneo
    Institut Curie, Centre de Recherche, 75005 Paris, France
    Proc Natl Acad Sci U S A 109:9053-8. 2012
    ..b>TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems...
  64. ncbi Ectopic expression of toll-like receptor-3 (TLR-3) overcomes the double-stranded RNA (dsRNA) signaling defects of P2.1 cells
    Yaping Sun
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    J Interferon Cytokine Res 24:350-61. 2004
    ....
  65. doi Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE
    M A Tewfik
    Department of Otolaryngology Head and Neck Surgery, Montreal General Hospital, McGill University, Montreal, Canada
    Allergy 64:746-53. 2009
    ..We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level...
  66. pmc A family of human receptors structurally related to Drosophila Toll
    F L Rock
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304 1104, USA
    Proc Natl Acad Sci U S A 95:588-93. 1998
    ....
  67. ncbi TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta
    Hiroyuki Oshiumi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 278:49751-62. 2003
    ..as an adapter that facilitates activation of IRF-3 followed by expression of interferon (IFN)-beta genes in TLR3 signaling, but TICAM-1 does not directly bind TLR4...
  68. pmc Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta
    Zhengfan Jiang
    University of Toronto, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 101:3533-8. 2004
    We have previously shown that double-stranded RNA-triggered, Toll-like receptor 3 (TLR3)-mediated signaling is independent of MyD88, IRAK4, and IRAK. Instead, TRAF6, TAK1, and TAB2 are recruited to TLR3 on poly(I.C) stimulation...
  69. ncbi Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population
    Pei Lin Cheng
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Transl Res 150:311-8. 2007
    ..screening for the single nucleotide polymorphisms (SNPs) in TLRs associated with viral infection, including TLR2, TLR3, TLR4, TLR7, TLR8, and TLR9...
  70. pmc The TLR3 signaling complex forms by cooperative receptor dimerization
    Joshua N Leonard
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:258-63. 2008
    ..Here, we describe the mechanism by which TLR3 recognizes its ligand, double-stranded RNA (dsRNA), and forms an active signaling complex...
  71. doi Functionally active toll-like receptor 3 on human primary and metastatic cancer cells
    T Matijevic
    Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
    Scand J Immunol 70:18-24. 2009
    Toll-like receptor 3 (TLR3) is a member of Toll-like receptors who recognize structurally conserved molecules derived from pathogens and trigger the immune response...
  72. doi Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis
    Christian Enevold
    Institute for Inflammation Research, National University Hospital, Copenhagen, Denmark
    J Rheumatol 37:905-10. 2010
    ..Toll-like receptors (TLR) have been implicated in the pathogenesis of arthritis. We investigated the role of functional variants of TLR in the disease phenotype and severity of rheumatoid arthritis (RA)...
  73. doi Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages
    Akira Koarai
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Respirology 17:1018-25. 2012
    ..Recently, toll-like receptor 3 (TLR3) was shown to recognize pathogen-associated molecular patterns, especially viral-derived double-stranded RNA, and ..
  74. ncbi Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    Saumendra N Sarkar
    Department of Molecular Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 11:1060-7. 2004
    Double-stranded RNA (dsRNA), a frequent byproduct of virus infection, is recognized by Toll-like receptor 3 (TLR3) to mediate innate immune response to virus infection...
  75. pmc Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3
    Christopher P Elco
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Virol 79:3920-9. 2005
    ..Thus, IRF-3 can suppress the expression of NF-kappaB-dependent genes in SeV-infected cells...
  76. ncbi Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes
    F J Pirie
    Department of Medicine, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    Tissue Antigens 66:125-30. 2005
    ..Parts of exon 4 and exon 3/intron 3 of the TLR3 gene were studied by polymerase chain reaction, direct sequencing and restriction enzyme digestion with Bts 1...
  77. pmc Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling
    Ingvild Bjellmo Johnsen
    Department of Laboratory Medicine, Children s and Women s Health, Institute of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    EMBO J 25:3335-46. 2006
    ..during the replication cycle of most viruses and triggers antiviral immune responses through Toll-like receptor 3 (TLR3)...
  78. ncbi Distinct functions between toll-like receptors 3 and 9 in retinal pigment epithelial cells
    Nobuyuki Ebihara
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Ophthalmic Res 39:155-63. 2007
    ..However, CpG-DNA motif enhanced phagocytosis in RPE cells. These results may indicate that TLR 3 and 9 play a distinct role in the inflammatory response that clears viruses from the retina...
  79. doi Single-nucleotide polymorphisms in genes encoding toll-like receptor -2, -3, -4, and -9 in case-control study with breast cancer
    Godfrey E Etokebe
    Faculty of Dentistry, Institute for Oral Biology, University of Oslo, Oslo, Norway
    Genet Test Mol Biomarkers 13:729-34. 2009
    ..Genetic susceptibility to cancer is multifactorial, and it is known that impairment of the immune system could contribute to risk for getting cancer...
  80. doi Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway
    Miwa Sasai
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Mol Immunol 47:1283-91. 2010
    Using yeast two-hybrid screening, we found three TRAF proteins TRAF1, 2 and 6, bound the N-terminal region of the TLR3/4 adaptor TICAM-1 (TRIF)...
  81. doi TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis
    Manabu Taura
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan
    Cancer Sci 101:1610-7. 2010
    Toll-like receptor 3 (TLR3) has gained recognition as a novel molecular target for cancer therapy because TLR3 activation by its synthetic ligand poly I:C directly causes tumor cell death...
  82. pmc A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages
    Yu Zhou
    Division of Virology, Wuhan Centres for Disease Control and Prevention, Wuhan, China
    Immunology 131:40-9. 2010
    ..These findings indicate that TLR-3-mediated induction of multiple anti-HIV factors should be beneficial for the treatment of HIV disease where innate immune responses are compromised by the virus...
  83. pmc Activation of Toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-β in cultured hepatoma cells
    Zhaoduan Liang
    Department of Immunology, Institute of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e23346. 2011
    ..Activation of TLR3 showed an antiviral effect, while pretreatment of other TLR ligands (including TLR1/2, TLR2/6, TLR4, TLR5 or TLR7/8)..
  84. pmc Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity
    Yiqi Guo
    1St Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, USA Laboratory of Human Genetics of Infectious Diseases, National Institute of Health and Medical Research, Paris, France Necker Medical School, Paris Descartes University, Paris 75015, France
    J Exp Med 208:2083-98. 2011
    Autosomal dominant TLR3 deficiency has been identified as a genetic etiology of childhood herpes simplex virus 1 (HSV-1) encephalitis (HSE)...
  85. ncbi Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains
    Masako Tanabe
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Biochem Biophys Res Commun 311:39-48. 2003
    ..Although dsRNA is a virus-specific signature and a ligand for human Toll-like receptor 3 (TLR3), largely uncharacterized multiple pathways associate virus-mediated IFN-beta induction...
  86. ncbi Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    Katalin Kariko
    Division of Neurosurgery and Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6545-9. 2004
    ..Secretion of these cytokines increased tremendously when HEK293 cells overexpressed Toll-like receptor 3 (TLR3), and the increased secretion of IFN-beta was inhibited by coexpression of an inhibitor of TIR domain-containing ..
  87. ncbi Preferential expression and function of Toll-like receptor 3 in human astrocytes
    Cinthia Farina
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Neuroimmunol 159:12-9. 2005
    ..Quantitative PCR for TLRs 1 to 10 showed a basal expression of TLR3 that could be enhanced by IFN-gamma, IL-1beta, and IFN-beta...
  88. ncbi Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH
    Odette de Bouteiller
    Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, 69571 Dardilly Cedex, France
    J Biol Chem 280:38133-45. 2005
    Studies involving Toll-like receptor 3 (TLR3)-deficient mice suggest that this receptor binds double-stranded RNA. In the present study, we analyzed ligand/receptor interactions and receptor-proximal events leading to TLR3 activation...
  89. ncbi Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    Kun Yang
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
    Immunity 23:465-78. 2005
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
  90. ncbi Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation
    Jingchuan Sun
    Department of Biology, Texas A and M University, College Station 77843, USA
    J Biol Chem 281:11144-51. 2006
    Toll-like receptors (TLRs) play critical roles in bridging the innate and adaptive immune responses. The human TLR3 recognizes foreign-derived double-stranded RNA and endogenous necrotic cell RNA as ligands...
  91. pmc Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  92. ncbi Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    Misako Matsumoto
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 2 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Biochem Biophys Res Commun 293:1364-9. 2002
    A monoclonal antibody (mAb) against human Toll-like receptor (TLR) 3 was established and its effect on TLR3-mediated responses was tested using human fibroblast cell lines expressing TLR3 on the cell surface...
  93. ncbi TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
    Hiroyuki Oshiumi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Japan
    Nat Immunol 4:161-7. 2003
    ..Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta...
  94. pmc Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA
    Rebecca L Jorgenson
    Department of Molecular Microbiology and Immunology, University of Missouri Columbia, School of Medicine, Columbia, MO 65212, USA
    Hum Immunol 66:469-82. 2005
    Toll-like receptor 3 (TLR3) responds to dsRNA, a product of most viral life cycles, and initiates production of proinflammatory and antiviral cytokines. The role of TLR3 in human mucosal immunity of the endometrium has not been examined...
  95. ncbi TLR3 can directly trigger apoptosis in human cancer cells
    Bruno Salaun
    Laboratory for Immunological Research Schering Plough Research Institute, Dardilly, France
    J Immunol 176:4894-901. 2006
    ..In this study we show that synthetic dsRNA induces apoptosis of human breast cancer cells in a TLR3-dependent manner, which involves the molecular adaptor Toll/IL-1R domain-containing adapter inducing IFN-beta and ..
  96. ncbi Herpes simplex virus 1 (HSV-1) DNA and immune complex (HSV-1-human IgG) elicit vigorous interleukin 6 release from infected corneal cells via Toll-like receptors
    Kozaburo Hayashi
    Immunology and Virology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Gen Virol 87:2161-9. 2006
    ..These results demonstrated that neutralized HSV immune complexes were as potent as HSV DNA in enhancing IL-6 release from corneal fibroblasts. These phenomena were mediated via augmented TLR-3 and -9 gene expression...
  97. ncbi Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    J Reprod Immunol 74:53-60. 2007
    ..We have examined the gene expression of TLR2, TLR3, TLR4, and TLR9 in endometrial tissues by real-time quantitative PCR and in situ hybridization...
  98. ncbi Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, Washington State, USA
    AIDS 21:441-6. 2007
    ..Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections...
  99. doi Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism
    Alessio Paone
    Department of Histology and Medical Embryology, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University of Rome, 00161 Rome, Italy
    Carcinogenesis 29:1334-42. 2008
    ..Since TLR3 has been recently suggested as a possible therapeutic target in some cancer cell lines, we studied TLR3 expression ..
  100. pmc Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells
    Yu Zhou
    Division of Virology, Wuhan Centers for Disease Control and Prevention, Wuhan, China
    J Neurosci Res 87:2916-25. 2009
    ..Human neuronal cells expressed TLR family members 1-10 and IFN-alpha/beta. The activation of TLR3 or TLR8 by double-stranded RNA (poly-I:C) or single-stranded RNA (ssRNA) induced IFN-alpha/beta expression...

Research Grants68

  1. ROBERT A LAFYATIS; Fiscal Year: 2015
    ..innate immune stimulated dermal fibrosis using this murine model, in which osmotic pumps containing poly(I:C), a TLR3 and RIGI-like receptor agonist, is implanted subcutaneously in mice...
  2. miR-155 regulation of cellular susceptibility to HIV-1 infection
    JULIO MARTIN-GARCIA; Fiscal Year: 2013
    ..LPS and poly(I:C) (TLR4 and TLR3 ligands, respectively), have been shown to inhibit HIV-1 replication in and infection of macrophages, albeit the ..
  3. Martin E Dorf; Fiscal Year: 2015
    ..The final Specific Aim will identify TBK1 associated molecules which regulate the RLR, TLR3, TLR4, or dsDNA signaling pathways...
  4. Cell-based assay for high-throughput screening of TLR3 activators
    Tsung Hsien Chuang; Fiscal Year: 2010
    ..In human cells, ten TLRs (TLR1 to TLR10) have been identified, each with their own specificities. TLR3 recognizes viral double-stranded (ds) RNA derived from the genomes of dsRNA viruses, or generated during the ..
  5. Maximizing Memory T Cell Responses by Matured Post Chemotherapy Dendritic Cells
    Mark P Rubinstein; Fiscal Year: 2012
    ..These DCs demonstrated normal phagocytic ability in vitro and antigen uptake in vivo. Administration of the TLR3 agonist poly(I:C) at the peak of DC expansion induced a rapid inflammatory milieu that was associated with ..
  6. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..rotavirus-like-particle (VLP) vaccines may require TLR signals (polyinosine-polycytidylic acid synthetic dsRNA, TLR3 ligand) with VitA to mimic the effect of RV dsRNA...
  7. Mechanisms of Immunosuppressive Actions of Glucocorticoids
    Inez Rogatsky; Fiscal Year: 2011
    ..Conversely, in response to bacterial or viral TLR3/4 ligands, IRF3 not only enhances cytokine transcription directly, but also depletes GRIP1 from GR:AP1and GR:NFx:B ..
  8. Demetrios Vavvas; Fiscal Year: 2014
    ..Yang et al (NEJM 2008) identified TLR3 polymorphism to be associated with AMD and that PolyI:C (analog of dsRNA) mediated activation of TLR 3 in animals ..
  9. Inflammatory and Chemotactic Cytokines in Bronchopulmonary Dysplasia
    Vedang A Londhe; Fiscal Year: 2011
    ..and genetic inhibition of CXCR2;and III)study the mechanism of dsRNA binding and signaling of Toll-like receptor 3 (TLR3) in the activation of human CXC chemokines and lung morphoregulatory genes in cultured human lung epithelial cells...
  10. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..mice with Lymphocytic choriomeningitis virus (LCMV) differentially modulates subsequent TLR challenges inhibiting TLR3, TLR7 and TLR9 responses and enhancing TLR4 signaling (Zuniga et al. Cell Host &Microbe. 2008)...
  11. Macrophage Produced Phospholipid Transfer Protein (PLTP)
    Linda K Curtiss; Fiscal Year: 2012
    ..will test the hypothesis that MF PLTP disrupts TLR2/1 plasma membrane dimerization and signaling, but not preformed TLR3 dimer mediated signaling in endosomes...
  12. Linking tumor chemoresistance to TLR variants that mediate damage chain reaction
    Nathalie Scholler; Fiscal Year: 2013
    ..All Toll-like receptors (TLRs), but TLR3, signal through MyD88, which triggers the production of proinflammatory cytokines...
  13. Xiaoyu Hu; Fiscal Year: 2014
    ..diseases, likely secondary to mediating responses to damaged tissues or cells (for example TLR2/4 in arthritis and TLR3/7/8/9 in lupus)...
  14. The role of fas signaling in rheumatoid arthritis
    Carla M Cuda; Fiscal Year: 2012
    ..These cells are highly activated, express increased levels of TLR3 and 4, and contribute to synovial inflammation and cartilage and bone destruction through the production of ..
  15. Is Toll-like receptor-3 signaling involved in Alzheimer's disease?
    DOUGLAS GORDON WALKER; Fiscal Year: 2013
    ..Both aims will be carried out in vitro using the TLR3- ligand poly IC and/or A[unreadable] stimulated human microglia and astrocytes described in Aim 1...
  16. Hiltonol provides potent neuroprotection from ischemic brain injury in stroke.
    Mary P Stenzel-Poore; Fiscal Year: 2013
    ..In this proposal we seek to evaluate Hiltonol(R), a synthetic dsRNA TLR3 ligand as a prophylactic neuroprotectant against stroke injury...
  17. FRANCOIS C BANEYX; Fiscal Year: 2014
    ..Both TLR3 and TLR9 agonists, polyinosinic:polycytidylic acid (poly IC) and CpG oligonucleotides (ODNs), are effective in ..
  18. Claudia V Jakubzick; Fiscal Year: 2016
    ..Our central hypothesis is that both TLR3+CD103+ DC and TLR7+CD11bhi lung DCs, possess the capacity to promote the development of cytotoxic T cells directed ..
  19. Gyongyi Szabo; Fiscal Year: 2016
    ..HCV represents danger signals for the host through Toll like receptor 7 and 8 that recognize ssRNA, TLR3 that senses dsRNA or TLR2 that is activated by HCV core and NSS proteins...
  20. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ..Cys, and MALP], the TLR5 stimulus flagellin, the TLR7 stimuli imidazoquinolines, the TLR9 stimulus CpG DNA, and the TLR3 stimulus poly-I-C, as well as classic Th2 inducers such as SEA and filarial proteins...
  21. Clustered receptor-signaling domains as novel HIV vaccine genetic adjuvants
    GEOFFREY WILLIAM STONE; Fiscal Year: 2012
    ..Certain TLR agonist combinations, such as mixtures of TLR2, TLR3, and TLR9 agonists, have been shown to synergistically increase both correlates of immunity and protection from ..
  22. MICHELLE ALICE KELLIHER; Fiscal Year: 2016
    ..Our published work reveals Rip1 as a critical mediator of the TNF- and TLR3/4, Trif-dependent NF-[unreadable]B pathways and the ubiquitin modification of Rip1 is essential for TNF- induced NF-..
  23. GEORGE ROBERT STARK; Fiscal Year: 2016
    ..Project 1 is designed to dissect multiple pathways associated with the action of TLR3 and associated factors (TRIF and IRF3) and their control of inflammation linked tumorigenesis...
  24. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..We have identified expression of TLR3, an innate immune pattern recognition receptor for duplex RNA, on multiple neuronal populations...
  25. Kui Li; Fiscal Year: 2016
    ..Our recent data suggest that human hepatocytes contain a functional Toll-like receptor-3 (TLR3) signaling pathway that senses HCV infection and leads to production of proinflammatory cytokines and chemokines ..
  26. c-Jun N-terminal kinase and joint destruction in RA
    Gary S Firestein; Fiscal Year: 2012
    ..g., TLR3 activation and anisomysin)...
  27. Role of TLR3 Signaling in Control of HCV
    Kui Li; Fiscal Year: 2012
    ..Our recent data suggest that human hepatocytes contain a functional Toll-like receptor-3 (TLR3) signaling pathway that senses HCV infection and leads to production of proinflammatory cytokines and chemokines ..
  28. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    ..the lack of ER[unreadable] is renal protective in female lupus mice by blunting the response of mesangial cells to TLR3/7 induced inflammation...
  29. A novel role for the TLR signaling adaptor TRAM
    Michael T Berton; Fiscal Year: 2013
    ..The current TLR paradigm asserts that all 13 mammalian TLRs, except TLR3, signal host cells via the adaptor MyD88, whereas TLR3 signals through a "MyD88-independent" pathway via the ..
  30. Pavan Reddy; Fiscal Year: 2016
    ..test the hypothesis that host CD8+DCs have the unique ability to cross-present TSAs and, that signaling through TLR3-->TRIF and Nod1/2-->Rip2 pathways will enhance their ability to exclusively augment GVL without aggravating ..
  31. Robert E Lanford; Fiscal Year: 2014
    ..In aim 4, we will knockdown the sensors of viral RNA in the liver leading to IFN production including RIG-I, TLR3 and IRF3...
  32. STUART KEITH CALDERWOOD; Fiscal Year: 2016
    ..treatment effectiveness and the degree to which vaccines can be used in combination with adjuvants such as TLR3 and TLR9 agonists as well as inhibitors of co-repressing molecule CTLA4...
  33. Ken Ichiro Fukuchi; Fiscal Year: 2014
    ..These hypotheses are investigated in Aim 1 and 2. All TLRs, with the exception of TLR3, activate the MyD88 pathways, whereas TLR3 and TLR4 activate the TRIF pathways...
  34. Yorgo Modis; Fiscal Year: 2015
    ..Viral RNA is recognized by!TLR3, TLR7 and TLR8, and microbial DNA is recognized by TLR9...
  35. Tolerance to TLR Ligands in the Intestinal Epithelium
    Anatoly V Grishin; Fiscal Year: 2010
    ..A20 induction may be also responsible for enterocyte tolerance and cross-tolerance to the ligands of TLR3 and TLR9, but not TLR5 ligand flagellin (Fla)...
  36. The Role of Microglia during TMEV-IDD in the Adult Mouse
    DANNE S DUNCAN; Fiscal Year: 2010
    ..Since, both TLR3 and PKR (pattern recognition receptors-PRRs) recognize viral double-stranded RNA, these molecules are most relevant ..
  37. Sanjay Rajagopalan; Fiscal Year: 2014
    ..In the third specific aim, we will screen specificity of PM2.5 for TLR4 using TLR4-/- /MyD88-/-/TLR3-/-/NOD-/- mice using an abbreviated intra-tracheal route of delivery...
  38. Yong Jun Liu; Fiscal Year: 2014
    ..two major classes of innate immune receptors for sensing microbial nucleic acids: Toll-like receptors (TLR: TLR3, 7, 8, 9) and retinoic acid-inducible gene I-like helicases (RLH: RIG-I, LGP2, MDA-5)...
  39. Novel TLR3 inhibitors for geographic atrophy of age-related macular degeneration
    Jayakrishna Ambati; Fiscal Year: 2010
    ..In a multi-center collaboration, we recently reported that a hypomorphic polymorphism in toll-like receptor-3 (TLR3), an innate immune sensor of double stranded RNA (dsRNA), conferred protection from GA, making it the first ..
  40. Activators and repressors of NFkappaB and IRF3/7 in innate immunity
    GEORGE ROBERT STARK; Fiscal Year: 2012
    ..negative regulators of pathways that activate NF-kB, IRF7 and IRF3 in response to Toll-like receptor 8 (TLR8) and TLR3, using genetic selections that their labs have already established...
  41. Masayuki Fukata; Fiscal Year: 2015
    ..By contrast, the TRIF pathway is only induced by TLR4 or TLR3 and supports regulatory responses through induction of IFN[unreadable]...
  42. Role of TRIF-dependent TLR signaling in intestinal immunity
    Masayuki Fukata; Fiscal Year: 2011
    ..By contrast, the TRIF pathway is only induced by TLR4 or TLR3 and supports regulatory responses through induction of IFNb...
  43. Akiko Maeda; Fiscal Year: 2016
    ..2) Subretinal accumulation of microglia/macrophages in Rdh8-/-Abca4-/- mice. (3) Tlr3-/- Rdh8-/-Abca4-/- mice displayed milder retinal degeneration with less inflammatory changes compared to Rdh8-/- ..
  44. Wenzhe Ho; Fiscal Year: 2014
    ..Astrocytes express certain members of the Toll-like receptors (TLR) family, in particular, TLR3, a major trigger of innate immune response to viral infections...
  45. Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    NEIL BOWLES; Fiscal Year: 2009
    ..Double stranded RNA is the primary ligand for TLR3 and we have shown that the integrity of the TLR3 signaling pathway is involved in protecting against enterovirus-..
  46. The Role of Toll-Like Receptor-3 in T1D and Efficacy of a Novel Therapeutic
    Kelly McCall; Fiscal Year: 2010
    ..b>TLR3 have recently been shown to be abnormally expressed directly on the pancreatic [unreadable] cells of patients with ..
  47. Wenzhe Ho; Fiscal Year: 2016
    ..Importantly, no study to date has addressed combined effects of heroin use and HCV on HIV infection as well as on TLR3/RIG-I-mediated innate immunity, which is a major barrier of fundamental understanding of the immunopathogenesis of ..
  48. Toll-Like Receptor 3 Activation in Astrocytes
    GREGORY KONAT; Fiscal Year: 2006
    ..The binding of dsRNA to its receptor, Toll-like receptor 3 (TLR3) triggers the secretion of proinflammatory cytokines and other mediators...
  49. Shen Ying Zhang; Fiscal Year: 2016
    ..We showed that HSE may result from a novel group of primary immunodeficiencies (PIDs), with autosomal dominant (AD) TLR3 and autosomal recessive (AR) UNC-93B deficiency...
  50. Activation of Innate Immunity by Small Ribonucleoprotein
    Westley Reeves; Fiscal Year: 2007
    ..of dsRNA produced by replicating RNA viruses activate innate immunity by binding to dsRNA binding proteins such as TLR3 and/or the dsRNA dependent protein kinase (PKR), causing increased production of type I interferon (IFN) leading to ..
  51. Shen Ying Zhang; Fiscal Year: 2016
    ..because of autosomal recessive UNC-93B deficiency and two others who presented with HSE due to autosomal dominant TLR3 deficiency...
  52. YPE PETER DE JONG; Fiscal Year: 2015
    ..of viral sensing, the HCV NS3-4A protease cleaves two adaptor molecules, MAVS and TRIF, rendering both RIG-I and TLR3 pathways ineffective and preventing the induction of interferons...
  53. Shen Ying Zhang; Fiscal Year: 2014
    ..of HSE remained unclear until we recently showed that the disease may result from single-gene mutations impairing TLR3-dependent, IFN-[unreadable]/[unreadable]-mediated immunity to HSV-1 in the central nervous system (CNS), in some ..
  54. JONATHAN MICHEAL SPERGEL; Fiscal Year: 2014
    ..molecular patterns, or DAMPs) can induce the expression of IL-8, ICAM-1, and RANTES through TLR2 and TLR3-dependent signal transduction pathways in the absence of pathogenic stimulation...
  55. GIUSEPPINA ALESSANDRA FARINA; Fiscal Year: 2014
    ..Interestingly more recently we found that polyIC, a toll like receptor 3 (TLR3) ligand, activates human fibroblasts (fb), inducing not only genes known to be regulated by IFNs but ..
  56. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..These PRRs, which include both TLRs (TLR3, TLR7, TLR8 and TLR9) and cytoplasmic RNA helicases (RIG-I, Mda-5 and possibly others) are capable of detecting ..
  57. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..In brief, the dsRNA receptor (TLR3) and the LPS receptor (TLR4) utilize a common TIR adapter molecule, disrupted by the Lps2 mutation...
  58. Robyn S Klein; Fiscal Year: 2016
    ..In addition, we have determined that TLR3 signaling affects the expression of neural precursor cell transcription factors Pax6 and nestin in several brain ..
  59. Nigel Mackman; Fiscal Year: 2016
    ..Toll-like receptor 3 (TLR3) plays a major role in the innate immune response to viruses...
  60. CD40 and TLR Agonists in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010
    ..anti-tumor activity and has shown potent anti-tumor effects in mice in combination with TLR agonists, especially TLR3 agonist poly IC:LC...
  61. NKIP signaling and functions
    John Cambier; Fiscal Year: 2009
    ..The goals of this proposal are to determine the mechanisms of NKIP action in signaling by TNF, IL-1, TLR3 and viral infection and its roles in inflammation and innate immunity against virus in vivo...
  62. BENJAMIN GOLDMAN-ISRAELOW; Fiscal Year: 2014
    ..Huh-7 cells, with a particular focus on the responses induced by the cellular viral RNA sensors RIG-I, MDA5, and TLR3. We will next examine the interaction between HCV and innate immune pathways in HepG2-HFL cells to determine ..
  63. Nucleic Acid Binding Polymers as Anti-Inflammatory Agents
    BRUCE ALAN SULLENGER; Fiscal Year: 2011
    ..RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing Toll-Like Receptors (TLR3, 7, 8 and 9)...
  64. Leishmania RNA virus (LRV) infectivity and host responses
    Stephen M Beverley; Fiscal Year: 2013
    ..of a dsRNA virus infecting some strains of Leishmania confers elevated pathology and metastasis, mediated by a TLR3-dependent inflammatory response...
  65. Kui Li; Fiscal Year: 2014
    ..that TRIM56 positively regulates innate immune signaling to interferon induction via the Toll-like receptor 3 (TLR3) pathway, although these two activities of TRIM56 seem to be uncoupled...
  66. Enterovirus Pathogenesis
    VINCENT RACANIELLO; Fiscal Year: 2007
    ..We will determine the roles of TLR3, TLR7/8, RIG-I, and MDA-5 in sensing poliovirus replication in mice and in cultured cells...
  67. Intrahepatic IRF-3 and NF-kB Signaling and Interferon Responses in Hepatitis C
    Stanley M Lemon; Fiscal Year: 2010
    ..through pathways initiated by the pathogen- associated molecular pattern (PAMP) receptors, Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)...
  68. Recombinant Adenoviral Vector with Encoded TLR3 Ligand for Protection Against VEE
    Sean Tucker; Fiscal Year: 2009
    ..The proposed Aims tests whether the combination of the VEE antigen with WCB's expressed TLR3 vector can sufficiently and practically improve immunogenicity and protection against VEE...