titin

Summary

Gene Symbol: titin
Description: titin
Alias: CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD, titin, connectin, rhabdomyosarcoma antigen MU-RMS-40.14
Species: human

Top Publications

  1. ncbi Molecular mechanics of cardiac titin's PEVK and N2B spring elements
    Kaori Watanabe
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 6520, USA
    J Biol Chem 277:11549-58. 2002
  2. ncbi Structural basis for activation of the titin kinase domain during myofibrillogenesis
    O Mayans
    European Molecular Biology Laboratory, Hamburg Outstation, Germany
    Nature 395:863-9. 1998
  3. pmc Calcium-dependent molecular spring elements in the giant protein titin
    Dietmar Labeit
    Anästhesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, 68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 100:13716-21. 2003
  4. ncbi Full-mouth rehabilitation following treatment of temporomandibular disorders and teeth-related signs and symptoms
    Ihab A Hammad
    College of Dentistry, King Saud University, PO Box 60169, Riyadh 11545, Saudi Arabia
    Cranio 23:289-96. 2005
  5. pmc Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 157:125-36. 2002
  6. pmc Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
    Giulia Mearini
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Cardiovasc Res 85:357-66. 2010
  7. ncbi Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms
    B Kolmerer
    EMBL, Heidelberg, Germany
    J Mol Biol 256:556-63. 1996
  8. ncbi The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin
    Aikaterini Kontrogianni-Konstantopoulos
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 278:3985-91. 2003
  9. pmc Towards a molecular understanding of titin
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 11:1711-6. 1992
  10. ncbi A regular pattern of two types of 100-residue motif in the sequence of titin
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nature 345:273-6. 1990

Research Grants

  1. CGRP Regulation of iNOS and MAP Kinases/Phosphatases in Trigeminal Ganglia Glia
    Paul L Durham; Fiscal Year: 2010
  2. Alexandre Dasilva; Fiscal Year: 2014
  3. Novel Treatment for the Relief of Chronic Orofacial Pain
    Richard Weiner; Fiscal Year: 2009
  4. RAGE, Inflammation and Temporomandibular Joint Disorders
    Regina Landesberg; Fiscal Year: 2006
  5. SCIENTIFIC CONGRESS ON OROFACIAL PAIN AND TMD
    James Fricton; Fiscal Year: 1993
  6. TMJ Intra-Articular Disorders: Impact on Pain, Functioning and Disability
    Eric L Schiffman; Fiscal Year: 2013
  7. Jeffrey C Nickel; Fiscal Year: 2015
  8. William Maixner; Fiscal Year: 2014
  9. Nanotechnology Enabled Temporomandibular Joint(TMJ)Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2012
  10. Nanotechnology Enabled Temporomandibular Joint (TMJ) Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2010

Detail Information

Publications216 found, 100 shown here

  1. ncbi Molecular mechanics of cardiac titin's PEVK and N2B spring elements
    Kaori Watanabe
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 6520, USA
    J Biol Chem 277:11549-58. 2002
    b>Titin is a giant elastic protein that is responsible for the majority of passive force generated by the myocardium...
  2. ncbi Structural basis for activation of the titin kinase domain during myofibrillogenesis
    O Mayans
    European Molecular Biology Laboratory, Hamburg Outstation, Germany
    Nature 395:863-9. 1998
    The giant muscle protein titin (connectin) is essential in the temporal and spatial control of the assembly of the highly ordered sarcomeres (contractile units) of striated muscle...
  3. pmc Calcium-dependent molecular spring elements in the giant protein titin
    Dietmar Labeit
    Anästhesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, 68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 100:13716-21. 2003
    Titin (also known as connectin) is a giant protein with a wide range of cellular functions, including providing muscle cells with elasticity...
  4. ncbi Full-mouth rehabilitation following treatment of temporomandibular disorders and teeth-related signs and symptoms
    Ihab A Hammad
    College of Dentistry, King Saud University, PO Box 60169, Riyadh 11545, Saudi Arabia
    Cranio 23:289-96. 2005
    The literature is replete with theories regarding temporomandibular disorders (TMD). However, there is a paucity of information concerning perceived malocclusion and other teeth-related signs and symptoms after full-mouth rehabilitation...
  5. pmc Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1
    Abigail S McElhinny
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Cell Biol 157:125-36. 2002
    The COOH-terminal A168-170 region of the giant sarcomeric protein titin interacts with muscle-specific RING finger-1 (MURF-1)...
  6. pmc Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
    Giulia Mearini
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Cardiovasc Res 85:357-66. 2010
    ..Since the diversity and specificity of UPS regulation lie in E3 ubiquitin ligases, we investigated whether the muscle-specific E3 ligases atrogin-1 or muscle ring finger protein-1 (MuRF1) mediate degradation of truncated cMyBP-C...
  7. ncbi Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms
    B Kolmerer
    EMBL, Heidelberg, Germany
    J Mol Biol 256:556-63. 1996
    b>Titin is a 3000 kDa large protein of vertebrate striated muscle which extends from Z discs to M lines...
  8. ncbi The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin
    Aikaterini Kontrogianni-Konstantopoulos
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 278:3985-91. 2003
    ..We used the yeast two-hybrid assay to determine whether sAnk1 interacts with titin, a giant myofibrillar protein that organizes the sarcomere...
  9. pmc Towards a molecular understanding of titin
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 11:1711-6. 1992
    b>Titin is at present the largest known protein (M(r) 3000 kDa) and its expression is restricted to vertebrate striated muscle. Single molecules span from M- to Z-lines and therefore over 1 micron...
  10. ncbi A regular pattern of two types of 100-residue motif in the sequence of titin
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nature 345:273-6. 1990
    b>Titin is the largest polypeptide yet described (relative molecular mass approximately 3 x 10(6); refs 1, 2) and an abundant protein of striated muscle. Its molecules are string-like and in vivo span from the M to Z-lines...
  11. ncbi Titins: giant proteins in charge of muscle ultrastructure and elasticity
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, Germany
    Science 270:293-6. 1995
    ..thick and thin filaments, vertebrate striated muscle contains a third filament system formed by the giant protein titin. Single titin molecules extend from Z discs to M lines and are longer than 1 micrometer...
  12. ncbi Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set
    M Pfuhl
    EMBL, Heidelberg, Federal Republic of Germany
    Structure 3:391-401. 1995
    b>Titin is a gigantic protein located in the thick filament of vertebrate muscles. The putative functions of titin range from interactions with myosin and other muscle proteins to a role in muscle recoil...
  13. ncbi A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy
    A Freiburg
    European Molecular Biology Laboratory, Structural Biology Division, Heidelberg, Germany
    Eur J Biochem 235:317-23. 1996
    ..proteins is believed to be due partly to their interaction with the giant muscle protein titin (also called connectin), which spans the entire sarcomere and may act as a molecular ruler...
  14. ncbi The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers
    M Gautel
    European Molecular Biology Laboratory, Structural Biology Division, Heidelberg, Germany
    J Cell Sci 109:2747-54. 1996
    The giant sarcomeric protein titin (also described as connectin) is composed mainly of immunoglobulin (Ig)-like and fibronectin type III (fn3)-like domains arranged consecutively...
  15. pmc Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin
    P Young
    European Molecular Biology Laboratory, Postfach 10 22 09, 69012 Heidelberg, Germany
    EMBO J 17:1614-24. 1998
    The sarcomeric Z-disk, the anchoring plane of thin (actin) filaments, links titin (also called connectin) and actin filaments from opposing sarcomere halves in a lattice connected by alpha-actinin...
  16. ncbi Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin
    A Mues
    Structural Biology Division, European Molecular Biology Laboratory, Heidelberg, Germany
    FEBS Lett 428:111-4. 1998
    The giant muscle protein titin/connectin plays a crucial role in myofibrillogenesis as a molecular ruler for sarcomeric protein sorting...
  17. ncbi The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains
    C M Goll
    EMBL Meyerhofstrasse 1, 69117, Heidelberg, Germany Institut de Biologie Structurale J P Ebel 41 Avenue des Martyrs, 38027 Grenoble, France
    Structure 6:1291-302. 1998
    b>Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II)...
  18. pmc The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity
    C C Gregorio
    Departments of Cell Biology and Anatomy, and Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Biol 143:1013-27. 1998
    b>Titin is a giant elastic protein in vertebrate striated muscles with an unprecedented molecular mass of 3-4 megadaltons. Single molecules of titin extend from the Z-line to the M-line...
  19. ncbi Titin: a molecular control freak
    J Trinick
    School of Biomedical Sciences, Leeds University, Leeds, UK LS2 9JT
    Trends Cell Biol 9:377-80. 1999
    Recent studies of the giant protein titin have shed light on its roles in muscle assembly and elasticity and include the surprising findings described here...
  20. ncbi Differential expression of cardiac titin isoforms and modulation of cellular stiffness
    O Cazorla
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Wash, USA
    Circ Res 86:59-67. 2000
    Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac muscle...
  21. ncbi Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain
    T Centner
    European Molecular Biology Laboratory, Heidelberg, D 69117, Germany
    J Mol Biol 306:717-26. 2001
    The giant myofibrillar protein titin contains within its C-terminal region a serine-threonine kinase of unknown function...
  22. ncbi Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
    M Kulke
    Institute of Physiology, University of Heidelberg, Heidelberg, Germany
    Circ Res 89:874-81. 2001
    The giant muscle protein titin contains a unique sequence, the PEVK domain, the elastic properties of which contribute to the mechanical behavior of relaxed cardiomyocytes...
  23. ncbi The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
    M L Bang
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Mannheim, Germany
    Circ Res 89:1065-72. 2001
    b>Titin is a giant vertebrate striated muscle protein with critical importance for myofibril elasticity and structural integrity...
  24. ncbi Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy
    Brenda Gerull
    Max Delbrueck Center for Molecular Medicine, D 13092 Berlin Buch, Germany
    Nat Genet 30:201-4. 2002
    ..in the gene encoding giant-muscle filament titin (TTN) cause autosomal dominant DCM linked to chromosome 2q31 (CMD1G; MIM 604145)...
  25. ncbi Structural and functional studies of titin's fn3 modules reveal conserved surface patterns and binding to myosin S1--a possible role in the Frank-Starling mechanism of the heart
    C Muhle-Goll
    European Molecular Biology Laboratory, Meyerhofstr 1, Heidelberg, D 69117, Germany
    J Mol Biol 313:431-47. 2001
    The A-band part of titin, a striated-muscle specific protein spanning from the Z-line to the M-line, mainly consists of a well-ordered super-repeat array of immunoglobulin-like and fibronectin-type III (fn3)-like domains...
  26. pmc Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin
    Peter Hackman
    Department of Medical Genetics and The Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland
    Am J Hum Genet 71:492-500. 2002
    ..The linked region includes the giant TTN gene, which encodes the central sarcomeric protein, titin. We have previously shown a secondary calpain-3 defect to be associated with TMD, which further underscored that ..
  27. ncbi Reverse engineering of the giant muscle protein titin
    Hongbin Li
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nature 418:998-1002. 2002
    ..The protein titin provides muscle with its passive elasticity...
  28. ncbi Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2
    Stephan Lange
    Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    J Cell Sci 115:4925-36. 2002
    ..enzymes creatine kinase, adenylate kinase and phosphofructokinase by interaction with the elastic filament protein titin in cardiomyocytes...
  29. ncbi Solution scattering suggests cross-linking function of telethonin in the complex with titin
    Peijian Zou
    European Molecular Biology Laboratory EMBL, Hamburg Outstation, EMBL c o Deutsches Electronen Synchrotron DESY, Notkestrasse 85, Germany
    J Biol Chem 278:2636-44. 2003
    Telethonin interacts specifically with the two Z-disk IG-like domains (Z1Z2) at the N terminus of titin, the largest presently known protein...
  30. ncbi The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    Ralph Knoll
    Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    Cell 111:943-55. 2002
    ..MLP interacts with and colocalizes with telethonin (T-cap), a titin interacting protein...
  31. ncbi The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules
    Melanie K Miller
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Mol Biol 333:951-64. 2003
    ..MARP family members contain within their ankyrin repeat region a binding site for the myofibrillar elastic protein titin. Within the myofibril, MARPs, myopalladin, and the calpain protease p94 appear to be components of a titin N2A-..
  32. ncbi Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
    Sherif F Nagueh
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6550 Fannin, SM 1256, Houston, TX 77030 2717, USA
    Circulation 110:155-62. 2004
    The role of the giant protein titin in patients with heart failure is not well established...
  33. ncbi Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
    I Makarenko
    Physiology and Biophysics Laboratory, University of Muenster, Muenster, Germany
    Circ Res 95:708-16. 2004
    ..In this study, we analyzed titin expression in left ventricles of 19 control human donors and 9 severely diseased (nonischemic) dilated ..
  34. ncbi The kinase domain of titin controls muscle gene expression and protein turnover
    Stephan Lange
    Muscle Signalling and Development, Randall Division, King s College London, London SE1 1UL, UK
    Science 308:1599-603. 2005
    The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load...
  35. pmc Hierarchical extensibility in the PEVK domain of skeletal-muscle titin
    A Nagy
    Department of Biophysics, University of Pecs, Faculty of Medicine, Pecs, H 7624 Hungary
    Biophys J 89:329-36. 2005
    b>Titin is the main determinant of passive muscle force. Physiological extension of titin derives largely from its PEVK (Pro-Glu-Val-Lys) domain, which has a different length in different muscle types...
  36. ncbi Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk
    Peijian Zou
    EMBL Hamburg c o DESY, Notkeststrasse 85, D 22603 Hamburg, Germany
    Nature 439:229-33. 2006
    ..using X-ray crystallography, how the amino terminus of the longest filament component, the giant muscle protein titin, is assembled into an antiparallel (2:1) sandwich complex by the Z-disk ligand telethonin...
  37. ncbi Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin
    Michael Mrosek
    Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    FASEB J 21:1383-92. 2007
    b>Titin forms an intrasarcomeric filament system in vertebrate striated muscle, which has elastic and signaling properties and is thereby central to mechanotransduction...
  38. ncbi C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy
    Virginie Carmignac
    Institut National de la Sante et de la Recherche Médicale U582, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, France
    Ann Neurol 61:340-51. 2007
    The giant protein titin is essential for striated muscle development, structure, and elasticity. All titin mutations reported to date cause late-onset, dominant disorders involving either skeletal muscle or the heart...
  39. pmc Secondary and tertiary structure elasticity of titin Z1Z2 and a titin chain model
    Eric H Lee
    Center for Biophysics and Computational Biology and Beckman Institute, College of Medicine, Department of Physics and Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Biophys J 93:1719-35. 2007
    The giant protein titin, which is responsible for passive elasticity in muscle fibers, is built from approximately 300 regular immunoglobulin-like (Ig) domains and FN-III repeats...
  40. ncbi Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle
    Henk Granzier
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Wegner Hall, Rm 205, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R557-67. 2007
    b>Titin is a giant filamentous elastic protein that spans from the Z-disk to M-band regions of the sarcomere. The I-band region of titin is extensible and develops passive force in stretched sarcomeres...
  41. ncbi Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin
    Simone Müller
    EMBL Hamburg Outstation, c o DESY, Notkestrasse 85, D 22603 Hamburg, Germany
    J Mol Biol 371:469-80. 2007
    Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin...
  42. pmc A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain
    Eleonore von Castelmur
    Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 105:1186-91. 2008
    Myofibril elasticity, critical to muscle function, is dictated by the intrasarcomeric filament titin, which acts as a molecular spring...
  43. doi Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle
    Chikako Hayashi
    Department of Enzymatic Regulation for Cell Functions Calpain Project, The Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo, Japan
    J Biol Chem 283:14801-14. 2008
    ..In addition, a small in-frame deletion in the N2A region of connectin/titin that impairs p94-connectin interaction causes a severe muscular dystrophy (mdm) in mice...
  44. pmc Mechanoenzymatics of titin kinase
    Elias M Puchner
    Chair for Applied Physics, Center for Integrated Protein Science Munich and Center for Nanoscience, Ludwig Maximilians Universitat Munchen, 80799 Munich, Germany
    Proc Natl Acad Sci U S A 105:13385-90. 2008
    ..In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to ..
  45. pmc The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
    Morten Bertz
    Physik Department E22, Technische Universitat Munchen, James Franck Strasse, 85748 Garching, Germany
    Proc Natl Acad Sci U S A 106:13307-133310. 2009
    ..In skeletal muscle, the giant protein titin is anchored in the Z-disk by telethonin...
  46. pmc PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness
    Carlos Hidalgo
    Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA
    Circ Res 105:631-8, 17 p following 638. 2009
    ..Myocardial sarcomeres also contain a third myofilament, titin, and it is unknown whether titin can be phosphorylated by PKC and whether it affects passive tension.
  47. doi Myopathies caused by homozygous titin mutations: limb-girdle muscular dystrophy 2J and variations of phenotype
    I Penisson-Besnier
    Departement de Neurologie, Centre de Référence des maladies Neuromusculaires, Centre Hospitalier Universitaire d Angers, 4 rue Larrey, 49933 Angers Cedex 9, France
    J Neurol Neurosurg Psychiatry 81:1200-2. 2010
    Limb-girdle muscular dystrophy 2J caused by mutations in C-terminal titin has so far been identified in Finnish patients only. This may in part be due to limited availability of diagnostic tests for titin defects...
  48. doi A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscle
    Lydie Laure
    Genethon, CNRS UMR8587 LAMBE, Evry, France
    FEBS J 277:4322-37. 2010
    ..CARP), and the calpain 3 protease was identified in the N2A elastic region of the giant sarcomeric protein titin. The present study aimed to investigate the function(s) of this complex in the skeletal muscle...
  49. pmc Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury
    Mohammad A M Ali
    Department of Pharmacology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Circulation 122:2039-47. 2010
    b>Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function...
  50. pmc Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes
    Matthew Taylor
    Adult Medical Genetics Program and Division of Cardiology, University of Colorado Denver, Aurora, USA
    Circulation 124:876-85. 2011
    ..We evaluated the cardiomyopathy gene titin (TTN) as a candidate ARVC gene because of its proximity to an ARVC locus at position 2q32 and the connection of ..
  51. pmc Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam
    J Appl Physiol (1985) 112:1157-65. 2012
    ..We hypothesized that in response to the increased compliance of the extracellular matrix in TNX-deficient EDS patients, intracellular adaptations take place in the elastic properties of the giant muscle protein titin.
  52. pmc Truncations of titin causing dilated cardiomyopathy
    Daniel S Herman
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 366:619-28. 2012
    Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size.
  53. pmc RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
    Wei Guo
    Muscle Biology Laboratory, University of Wisconsin Madison, USA
    Nat Med 18:766-73. 2012
    ..has a major role in cardiac adaptive responses, as exemplified by the isoform switch of the sarcomeric protein titin, which adjusts ventricular filling...
  54. pmc Titin mutation segregates with hereditary myopathy with early respiratory failure
    Gerald Pfeffer
    Institute of Genetic Medicine, Central Parkway, Newcastle, NE1 3BZ, UK
    Brain 135:1695-713. 2012
    ..A combination of genome-wide linkage and whole exome sequencing revealed the likely causal genetic variant in the titin (TTN) gene (g.274375T>C; p.Cys30071Arg) within a shared haplotype of 2.93 Mbp on chromosome 2...
  55. doi Hereditary myopathy with early respiratory failure associated with a mutation in A-band titin
    Monica Ohlsson
    Department of Pathology, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden
    Brain 135:1682-94. 2012
    ..274375T>C; p.Cys30071Arg, in the titin gene (TTN)...
  56. doi Exome sequencing identifies a novel TTN mutation in a family with hereditary myopathy with early respiratory failure
    Rumiko Izumi
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    J Hum Genet 58:259-66. 2013
    ..groups reported three mutations in TTN in patients with hereditary myopathy with early respiratory failure (HMERF, MIM #603689), which is characterized by overlapping pathologic findings with MFMs...
  57. ncbi Dissecting titin into its structural motifs: identification of an alpha-helix motif near the titin N-terminus
    G Musco
    EMBL, Heidelberg, Germany
    Biochemistry 34:553-61. 1995
    Titin, also known as connectin, is a giant modular protein specifically found in vertebrate striated muscle...
  58. pmc Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro
    K J Eilertsen
    Molecular Biophysics Program, Florida State University, Tallahassee 32306 3050
    J Cell Biol 126:1201-10. 1994
    We previously discovered a cellular isoform of titin (originally named T-protein) colocalized with myosin II in the terminal web domain of the chicken intestinal epithelial cell brush border cytoskeleton (Eilertsen, K.J., and T.C.S...
  59. ncbi Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin
    M Gautel
    European Molecular Biology Laboratory, Heidelberg, Germany
    Neurology 43:1581-5. 1993
    ..Analysis of the isolated cDNAs show that all share a common sequence encoding a distinct region of the titin gene...
  60. pmc Studies of the interaction between titin and myosin
    A Houmeida
    Department of Veterinary Clinical Sciences, Bristol University, Langford, United Kingdom
    J Cell Biol 131:1471-81. 1995
    The interaction of titin with myosin has been studied by binding assays and electron microscopy. Electron micrographs of the titin-myosin complex suggest a binding site near the tip of the tail of the myosin molecule...
  61. ncbi Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs
    K Kinbara
    Department of Molecular Biology, Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Japan
    Arch Biochem Biophys 342:99-107. 1997
    ..two-hybrid system, we have recently reported that skeletal muscle-specific calpain, p94, binds specifically to connectin (or titin), a gigantic muscle elastic protein...
  62. pmc Actin-titin interaction in cardiac myofibrils: probing a physiological role
    W A Linke
    Institute of Physiology II, University of Heidelberg, Germany
    Biophys J 73:905-19. 1997
    The high stiffness of relaxed cardiac myofibrils is explainable mainly by the expression of a short-length titin (connectin), the giant elastic protein of the vertebrate myofibrillar cytoskeleton...
  63. pmc Autosomal dominant myopathy with proximal weakness and early respiratory muscle involvement maps to chromosome 2q
    P Nicolao
    Department of Molecular Medicine, Clinical Neurogenetic Unit, CMM L8 02 058, Karolinska Hospital, S 17176, Stockholm, Sweden
    Am J Hum Genet 64:788-92. 1999
    ..The affected individuals from these two families share an identical haplotype, which suggests a common origin...
  64. ncbi Differential actin binding along the PEVK domain of skeletal muscle titin
    Attila Nagy
    Department of Biophysics, University of Pecs, Faculty of Medicine, Szigeti út 12 Pécs 7624, Hungary
    J Cell Sci 117:5781-9. 2004
    Parts of the PEVK (Pro-Glu-Val-Lys) domain of the skeletal muscle isoform of the giant intrasarcomeric protein titin have been shown to bind F-actin. However, the mechanisms and physiological function of this are poorly understood...
  65. doi The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin
    Rainer M Bucher
    Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstr 70, CH 4056 Basel, Switzerland
    J Mol Biol 401:843-53. 2010
    b>Titin is a large intrasarcomeric protein that, among its many roles in muscle, is thought to modulate the in vivo assembly of the myosin motor filament...
  66. ncbi Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity
    A Freiburg
    European Molecular Biology Laboratory, Heidelberg, Germany
    Circ Res 86:1114-21. 2000
    Titins are megadalton-sized filamentous polypeptides of vertebrate striated muscle. The I-band region of titin underlies the myofibrillar passive tension response to stretch...
  67. ncbi Mechanical strength of the titin Z1Z2-telethonin complex
    Eric H Lee
    Center for Biophysics and Computational Biology and Beckman Institute, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    Structure 14:497-509. 2006
    Using molecular dynamics simulations, we have explored the mechanical strength of the titin Z1Z2-telethonin complex, namely, its ability to bear strong forces such as those encountered during passive muscle stretch...
  68. ncbi Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells
    Koichi Ojima
    Department of Enzymatic Regulation for Cell Function, The Metropolitan Institute of Medical Science Rinshoken, 3 18 22 Honkomagome, 113 8613, Bunkyo ku, Tokyo, Japan
    J Muscle Res Cell Motil 26:409-17. 2005
    ..It was also identified by the yeast two hybrid studies that p94 binds to the N2A and M-line regions of connectin. Furthermore, genetic studies indicate that p94 is indispensable for skeletal muscles, although its precise ..
  69. ncbi The effects of streptomycin/lidocaine block on trigeminal neuralgia: a double blind crossover placebo controlled study
    G T Bittar
    Pain Management Center, UCLA School of Dentistry 90024
    Headache 33:155-60. 1993
    ..Side effects including facial swelling and pain were a common finding in the patients receiving streptomycin. This study demonstrated no beneficial effects of streptomycin blockade for idiopathic and traumatic trigeminal neuralgia...
  70. ncbi Kineziographic research of patients with cross bite
    R Grzić
    Department of Dental Pathology and Prosthodontics, School of Dental Medicine, University of Rijeka, Croatia
    Coll Antropol 24:57-62. 2000
    ..10 patients with unilateral cross-bite and 10 students without any symptoms of temporomandibular disorders (TMD)...
  71. ncbi Restoring force development by titin/connectin and assessment of Ig domain unfolding
    Nair Preetha
    Department VCAPP, Washington State University, Pullman, WA 99164 6520, USA
    J Muscle Res Cell Motil 26:307-17. 2005
    Titin/connectin is the main determinant of physiological levels of passive muscle force...
  72. pmc Sorting of yeast alpha 1,3 mannosyltransferase is mediated by a lumenal domain interaction, and a transmembrane domain signal that can confer clathrin-dependent Golgi localization to a secreted protein
    T R Graham
    Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Mol Biol Cell 6:809-24. 1995
    ..The N-terminal transmembrane domain (TMD) of Mnn1p is sufficient to localize invertase to the Golgi complex by a mechanism that is not saturable by ..
  73. ncbi Social influences on morphine conditioned place preference
    T L Coventry
    Department of Psychology, University of Wales, UK
    Behav Pharmacol 8:575-84. 1997
    ..animals and singly housed animals were then subjected to defeat by a male of the aggressive Tryon Maze Dull (TMD) strain, either 1 (singly housed animals only) 3 or 7 days prior to the first conditioning session...
  74. ncbi An epidemiological study of temporomandibular disorders in university students of Taiwan
    Y Y Shiau
    Department of Fixed Prosthodontics and Occlusion, School of Dentistry, National Taiwan University, Taipei
    Community Dent Oral Epidemiol 20:43-7. 1992
    A total of 2033 university students were surveyed for the prevalence of TMD in Taiwan. It was found that 42.9% of the students had one or more signs related to TMD, and females were slightly more frequently found...
  75. ncbi Symptoms and signs of temporomandibular disorders and oral parafunctions among Saudi children
    N M A Farsi
    Faculty of Dentistry, Department of Preventive Dental Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
    J Oral Rehabil 30:1200-8. 2003
    This study aimed to record the prevalence of signs and symptoms of temporomandibular disorders (TMD) and oral parafunctions among Saudi children...
  76. ncbi Validity of a brief questionnaire in screening asymptomatic subjects from subjects with tension-type headaches or temporomandibular disorders
    G E Gerstner
    Dept. of Cariology and General Dentistry, School of Dentistry, University of Michigan, Ann Arbor 48109-1078
    Community Dent Oral Epidemiol 22:235-42. 1994
    ..However, results also showed that the questionnaire was unable to distinguish easily between TMD subjects and temporalis region tension-type headache subjects.
  77. doi Bacterial diversity in synovial fluids of patients with TMD determined by cloning and sequencing analysis of the 16S ribosomal RNA gene
    Wei Sun
    Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:566-71. 2008
    ..was to examine the presence of bacteria in synovial fluids from patients with temporomandibular joint disorder (TMD) by polymerase chain reaction (PCR) targeting the 16S ribosomal RNA (rRNA) gene, followed by cloning and sequencing.
  78. doi Age peaks of different RDC/TMD diagnoses in a patient population
    Daniele Manfredini
    TMD Clinic, University of Padova, Italy
    J Dent 38:392-9. 2010
    To evaluate the prevalence of different Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) diagnoses in a population of patients seeking for TMD treatment at a tertiary clinic in Northern Italy; to evaluate the ..
  79. ncbi Comparison of masticatory dysfunction in temporomandibular disorders and fibromyalgia
    D Manfredini
    Section of Prosthetic Dentistry, Department of Neurosciences, University of Pisa, Pisa, Italy
    Minerva Stomatol 53:641-50. 2004
    Many theories have been proposed as to the relationship between fibromyalgia (FM) and temporomandibular disorders (TMD)...
  80. ncbi Pharmacologic interventions in the treatment of temporomandibular disorders, atypical facial pain, and burning mouth syndrome. A qualitative systematic review
    Thomas List
    Orofacial Pain Unit, Department of Stomatognathic Physiology, Malmo University, SE 214 21 Malmö, Sweden
    J Orofac Pain 17:301-10. 2003
    ..pain-relieving effect and safety of pharmacologic interventions in the treatment of chronic temporomandibular disorders (TMD), including rheumatoid arthritis (RA), as well as atypical facial pain (AFP), and burning mouth syndrome (BMS).
  81. ncbi Effectiveness of low-level laser therapy in temporomandibular joint disorders: a placebo-controlled study
    H Fikackova
    Institute of Biophysics and Informatics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Photomed Laser Surg 25:297-303. 2007
    Low-level laser therapy (LLLT) treatment for pain caused by temporomandibular joint disorders (TMD) was investigated in a controlled study comparing applied energy density, subgroups of TMD, and duration of disorders.
  82. doi The diagnostic value of the upper lip bite test combined with sternomental distance, thyromental distance, and interincisor distance for prediction of easy laryngoscopy and intubation: a prospective study
    Zahid Hussain Khan
    Department of Anesthesiology, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Anesth Analg 109:822-4. 2009
    ..whether the combination of the ULBT classification with sternomental distance (SMD), thyromental distance (TMD), and interincisor distance (IID) or a composite score can improve the ability to predict easy laryngoscopy and ..
  83. ncbi Is temporomandibular dysfunction a cranial dystonia? An electrophysiological study
    F Raudino
    Neurological Department, Valduce Hospital, Como, Italy
    Headache 34:471-5. 1994
    In 26 patients suffering from temporomandibular dysfunction (TMD) the silent period (ES), which consists of an early (ES1) and a late (ES2) inhibition which interrupts the voluntary electromyographic activity after an electrical stimulus,..
  84. ncbi Developmental relationship of myosin binding proteins (myomesin, connectin and C-protein) to myosin in chicken somites as studied by immunofluorescence microscopy
    Y G Yang
    Department of Anatomy and Cell Biology, School of Medicine, Chiba University, Japan
    Cell Struct Funct 25:177-85. 2000
    The developmental relationship of myosin binding proteins (myomesin, connectin and C-protein) to myosin was studied in chicken cervical somites by immunofluorescence microscopy...
  85. ncbi Depression and somatization in patients with temporomandibular disorders
    Adrian U J Yap
    Faculty of Dentistry, Department of Restorative Dentistry, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Republic of Singapore
    J Prosthet Dent 88:479-84. 2002
    ..Psychological and behavioral traits may be important for the diagnosis and management of orofacial pain...
  86. ncbi The relationship between jaw injury, third molar removal, and orthodontic treatment and TMD symptoms in university students in Japan
    Rahena Akhter
    Department of Preventive Dentistry, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan
    J Orofac Pain 22:50-6. 2008
    To determine the association between temporomandibular disorders (TMD) and experiences of jaw injury, third molar removal, and orthodontic treatment, controlling for confounding factors such as age, sex, emotional stress, and oral ..
  87. doi Comparison of the upper lip bite test with measurement of thyromental distance for prediction of difficult intubations
    Alireza Salimi
    Department of Anesthesiology, Loghman Hakim Hospital, Shahid Beheshti University, M C, Tehran, Iran
    Acta Anaesthesiol Taiwan 46:61-5. 2008
    ..Given the necessity for evaluation and re-evaluation of a newer predictive method, this study was conducted to compare the ULBT with another method for difficult airway prediction, the measurement of thyromental distance (TMD).
  88. ncbi Prevalence of different temporomandibular joint sounds, with emphasis on disc-displacement, in patients with temporomandibular disorders and controls
    Lars Elfving
    Department of Stomatognathic Physiology, Institute for Postgraduate Dental Education, Jonkoping, Sweden
    Swed Dent J 26:9-19. 2002
    Temporomandibular joint (TMJ) sounds are very common among patients with temporomandibular disorders (TMD), but also in non-patient populations. A variety of different causes to TMJ-sounds have been suggested e.g...
  89. ncbi Electrophoretic separation of the synovial fluid proteins in patients with temporomandibular joint disorders
    Kazuma Fujimura
    Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa Prefecture, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:463-8. 2006
    The present study was performed to characterize the patterns of protein expression in the synovial fluid (SF) of patients with temporomandibular joint disorders (TMD) by electrophoretic fractionation.
  90. ncbi Maximal bite force in young adults with temporomandibular disorders and bruxism
    Raquel Aparecida Pizolato
    Department of Physiological Sciences, School of Dentistry of Piracicaba, State University of Campinas, Brazil
    Braz Oral Res 21:278-83. 2007
    Parafunctional habits, such as bruxism, are contributory factors for temporomandibular disorders (TMD). The aim of this study was to evaluate the maximal bite force (MBF) in the presence of TMD and bruxism (TMDB) in young adults...
  91. pmc A pilot whole systems clinical trial of traditional Chinese medicine and naturopathic medicine for the treatment of temporomandibular disorders
    Cheryl Ritenbaugh
    Department of Family and Community Medicine, The University of Arizona, Tucson, AZ 85719, USA
    J Altern Complement Med 14:475-87. 2008
    ..acceptability of studying whole systems of Traditional Chinese Medicine (TCM) and Naturopathic medicine (NM) in the treatment of temporomandibular disorders (TMD), and to determine whether there is indication to support further research.
  92. doi Relationship between bruxism and temporomandibular disorders: a systematic review of literature from 1998 to 2008
    Daniele Manfredini
    TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e26-50. 2010
    The present paper aims to systematically review the literature on the temporomandibular disorders (TMD)-bruxism relationship published from 1998 to 2008.
  93. ncbi Treatment of temporomandibular disorders by stabilising splints in general dental practice: results after initial treatment
    R W Wassell
    Department of Restorative Dentistry, The School of Dental Sciences, Framlington Place, Newcastle upon Tyne NE2 4BW
    Br Dent J 197:35-41; discussion 31; quiz 50-1. 2004
    Little is known about how effective general dental practitioners (GDPs) are in treating temporomandibular disorders (TMD)...
  94. ncbi Risk factors for headache, including TMD signs and symptoms, and their impact on quality of life. Results of the Study of Health in Pomerania (SHIP)
    Olaf Bernhardt
    Department of Restorative Dentistry, Periodontology and Pediatric Dentistry, School of Dentistry, University of Greifswald, 17487 Greifswald, Germany
    Quintessence Int 36:55-64. 2005
    The aim of this investigation was to evaluate the role of various signs and symptoms of temporomandibular disorders (TMD), among other potential risk factors, in developing frequent headache in a population-based sample of the cross-..
  95. ncbi A prospective investigation over two decades on signs and symptoms of temporomandibular disorders and associated variables. A final summary
    Tomas Magnusson
    Department of Stomatognathic Physiology, The Institute for Postgraduate Dental Education, Jonkoping, Sweden
    Acta Odontol Scand 63:99-109. 2005
    The aim of this summary of a longitudinal investigation on temporomandibular disorders (TMD) was to present the prevalence figures of signs and symptoms of TMD and certain other examined variables, and the correlations between these ..
  96. ncbi Longitudinal changes in temporomandibular disorders in young adults: indication for systematic temporomandibular joint screening
    Ute Jensen
    Poliklinik für Kieferorthopädie, Justus Liebig Universitat Giessen, Schlangenzahl 14, 35392, Giessen, Germany
    J Orofac Orthop 68:501-9. 2007
    ..this study was to investigate longitudinal changes in temporomandibular joint function in young adults in terms of clinical and subclinical temporomandibular disorders (TMD), and to identify patients at risk for clinically manifest TMD.
  97. ncbi A randomized clinical trial using research diagnostic criteria for temporomandibular disorders-axis II to target clinic cases for a tailored self-care TMD treatment program
    Samuel F Dworkin
    Washington State Dental Foundation, University of Washington, Departments of Oral Medicine and Psychiatry and Behavioral Sciences, Box 356370, Seattle, WA 98195, USA
    J Orofac Pain 16:48-63. 2002
    To carry out a randomized clinical trial (RCT) contrasting usual conservative treatment of TMD by clinical TMD specialists with a structured self-care intervention, targeted to clinic cases independent of TMD physical diagnosis, who were ..
  98. ncbi Association of malocclusion and functional occlusion with temporomandibular disorders (TMD) in adults: a systematic review of population-based studies
    Dietmar Gesch
    Department of Orthodontics, Center of Oral Health, University of Greifswald, Greifswald, Germany
    Quintessence Int 35:211-21. 2004
    ..occlusion (eg, occlusal interferences, nonworking-side occlusal contacts) and temporomandibular disorders (TMD) in adults 20 years or older...
  99. ncbi Ethnic differences in temporomandibular disorders between Jewish and Arab populations in Israel according to RDC/TMD evaluation
    Shoshana Reiter
    Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger, School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Orofac Pain 20:36-42. 2006
    To use the Axis I and Axis II test items of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) to study the differences in temporomandibular disorders (TMD) between Israeli Arabs and Israeli Jews.
  100. pmc The extent of the psychological impairment of prosthodontic outpatients at a German University Hospital
    Michelle A Ommerborn
    Department of Operative and Preventive Dentistry and Endodontics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Head Face Med 4:23. 2008
    ..outpatients of the Department of Prosthodontics at the University of Duesseldorf and patients seeking care at the TMD/Orofacial Pain Outpatient Clinic (TMD/OFPOC) at the same university with respect to sociodemographic data, self-..
  101. doi The effects of manual therapy and exercise directed at the cervical spine on pain and pressure pain sensitivity in patients with myofascial temporomandibular disorders
    R La Touche
    Faculty of Medicine, Department of Physical Therapy, Universidad San Pablo CEU, Madrid, Spain
    J Oral Rehabil 36:644-52. 2009
    ..the effects of the treatments directed at the cervical spine in patients with temporomandibular disorders (TMD)...

Research Grants67

  1. CGRP Regulation of iNOS and MAP Kinases/Phosphatases in Trigeminal Ganglia Glia
    Paul L Durham; Fiscal Year: 2010
    ..sustain a pathological inflammatory cycle central to chronic inflammation and pain associated with TMJ disorders (TMD)...
  2. Alexandre Dasilva; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Chronic temporomandibular joint disorders (TMD) represent clinical problems in which empirical treatments offer uncertain relief for a large number of patients...
  3. Novel Treatment for the Relief of Chronic Orofacial Pain
    Richard Weiner; Fiscal Year: 2009
    ..Temporomandibular joint disorders (TMD) are one of the biggest segments of facial pain...
  4. RAGE, Inflammation and Temporomandibular Joint Disorders
    Regina Landesberg; Fiscal Year: 2006
    Disorders of the temporomandibular joint represent a common cause of facial pain. Although the precise etiology of TMD is yet to be fully elucidated, histological and arthroscopic studies suggest that especially at the late stages of ..
  5. SCIENTIFIC CONGRESS ON OROFACIAL PAIN AND TMD
    James Fricton; Fiscal Year: 1993
    ....
  6. TMJ Intra-Articular Disorders: Impact on Pain, Functioning and Disability
    Eric L Schiffman; Fiscal Year: 2013
    ..The recently completed Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Validation Project (U01 DEO13331) demonstrated that 1) TMJ imaging is required to diagnose TMJ intra-articular ..
  7. Jeffrey C Nickel; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Temporomandibular disorders (TMD) have estimated annual health and societal costs of $4 billion (Stowell et al., 2007). Women are 1.5-2 times more likely to be afflicted...
  8. William Maixner; Fiscal Year: 2014
    ..migraine (EM), vulvar vestibulitis (VVS), irritable bowel syndrome (IBS), and temporomandibular joint disorders (TMD)...
  9. Nanotechnology Enabled Temporomandibular Joint(TMJ)Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Temporomandibular Disorders (TMD) represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue ..
  10. Nanotechnology Enabled Temporomandibular Joint (TMJ) Prosthesis
    RAYMOND G THOMPSON; Fiscal Year: 2010
    Temporomandibular Disorders (TMD) usually represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue structures...
  11. Michael T Smith; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Temporomandibular joint disorders (TMD) are a prevalent and costly public health challenge, affecting a large number of otherwise generally healthy adults. Yet they remain poorly understood...
  12. FOUR TREATMENT STRATEGIES FOR TMJ DISK DISPLACEMENT
    Eric Schiffman; Fiscal Year: 2002
    Treatment for Temporomandibular Disorders (TMD) varies between nonsurgical and surgical interventions. Follow-up studies have shown positive outcomes with either type of intervention...
  13. MENSTRUAL CYCLE AND BLOOD EFFECTS ON ACUTE PAIN
    Jeffrey Sherman; Fiscal Year: 2001
    DESCRIPTION: (Adapted from applicant's abstract) Temporomandibular disorders (TMD's) are a group of pain conditions characterized by pain in the muscles of mastication and/or the temporomandibular joint...
  14. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    Temporomandibular disorders (TMD) affect approximately 12% of the US population, predominately women in their childbearing years and of those affected by TMD, greater than 60% have masticatory muscle pain as their main complaint...
  15. PERIPHERAL NMDA RECEPTORS AND TMD PAIN MECHANISMS
    Barry Sessle; Fiscal Year: 2006
    ..to block glutamate-induced pain in these healthy subjects as well as ongoing clinical pain in RA or myofascial TMD patients that are dependent on sex steroid hormones; and (E)) if there is a difference in human masseter or TMJ ..
  16. PHARMACOLOGICAL MANAGEMENT OF TEMPOROMANDIBULAR PAIN
    Benjamin White; Fiscal Year: 2001
    ..Data on the effectiveness of alternative treatments for pain associated with TMD (TMP) is lacking, and persons with TMD have been subjected to a wide range of treatments-surgical, noninvasive, ..
  17. Shamanic Healing for Women with TMD
    Nancy Vuckovic; Fiscal Year: 2004
    ..Traditional treatment outcomes for TMD pain are often unsatisfactory...
  18. Comorbid Chronic Pain Conditions - Mechanisms, Diagnosis and Treatments
    Allen W Cowley; Fiscal Year: 2011
    ..First, the number of people affected in the U.S. by temporomandibular disorders (TMD) is estimated to be approximately 36 million. The majority are women in their childbearing years...
  19. Effect of COMT genetic polymorphism on response to propranolol therapy in TMD
    INNA EVGENIEVNA TCHIVILEVA; Fiscal Year: 2012
    ..antagonist, propranolol, compared to placebo for treatment of pain in patients with temporomandibular disorder (TMD). TMD, one of the most common chronic musculoskeletal pain conditions, is ineffectively treated...
  20. Effects of cumulative stress and change in pain regulation on risk of chronic TMD
    GARY DOUGLAS SLADE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Each year, millions of Americans develop painful temporomandibular disorders (TMD), and symptoms become chronic for as many as one third of them...
  21. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..the role of craniofacial primary afferent neurons in musculoskeletal disorders such as temporomandibular disorders (TMD) and fibromyalgia (FM) using animal models...
  22. FACIAL BEHAVIOR RELATED TO ACUTE DENTAL PAIN
    Linda LeResche; Fiscal Year: 1993
    ..disgust and contempt) in patients experiencing pain from initial episodes of Temporomandibular Disorders (TMD) or from chronic TMD. 2...
  23. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ..by applicant): Orofacial pain encompasses a multitude of disorders, including temporomandibular disorders (TMD), trigeminal neuralgia, headaches (e.g...
  24. TMD LONGITUDINAL STUDIES: CLINICAL/CHRONIC PAIN SYNDROME
    Linda LeResche; Fiscal Year: 2003
    This application requests continuation of the Program Project TMD Longitudinal Studies: Clinical/Chronic Pain Syndromes...
  25. NEURAL CONTROL OF THE JAW UNDER PAIN
    Norman Capra; Fiscal Year: 2000
    ..Abstract): The goal of the proposal is to understand how muscle pain associated with temporomandibular disorders (TMD) affects neuromotor performance in primates...
  26. INTERNAT. CONSORTIUM FOR RESEARCH ON TMJ DISORDERS
    Samuel Dworkin; Fiscal Year: 2001
    ..for developing standardized examination and diagnostic approaches, including the Research Diagnostic Criteria for TMD (RDC/TMD), all of which will be available to the consortium and which will constitute a central component of the ..
  27. SEX DIFFERENCES--N REGIONAL U OPIOID RECEPTOR PAIN PROC
    Jon Kar Zubieta; Fiscal Year: 2000
    ..the experience of pain, and the prevalence of certain chronic pain conditions, such as temporomandibular disorders (TMD)...
  28. CHRONIC PAIN/TMDS IN YOUNG WOMEN
    Octavia Plesh; Fiscal Year: 1999
    ..The purpose of this investigation is to determine the prevalence of chronic pain and temporomandibular disorders (TMD) and factors associated with TMDs in an established, population-based cohort of young women...
  29. PSYCHOSOCIAL STRESS, BRUXISM, AND MYOFASCIAL TMD
    Karen Raphael; Fiscal Year: 2000
    DESCRIPTION: This study will examine the role of stress, distress and bruxism in pain exacerbation in myofascial TMD. It will also evaluate the role of bruxism in moderating the efficacy of a commonly used oral appliance...
  30. ORWH: SCOR on Sex and Gender Factors Affecting Women's *
    Joel Greenspan; Fiscal Year: 2006
    ..models of chronic pain conditions that are more prevalent in women, focusing on temporomandibular joint disorders (TMD) and the visceral pain associated with conditions such as irritable bowel syndrome (113S)...
  31. JOSHUA EMRICK; Fiscal Year: 2016
    ..muscles involved in mastication (myositis), or temporomandibular joint (arthritis or temporomandibular disorder/TMD)...
  32. Contribution of ADA1A polymorphism to persistent pain states
    SHAD BENJAMIN SMITH; Fiscal Year: 2010
    ..of idiopathic disorders, such as fibromyalgia, irritable bowel syndrome, and temporomandibular joint disease (TMD), is disregulation of the adrenergic neurotransmitter system...
  33. Development of an ex vivo derived laser drilled temporomandibular disc scaffold
    PETER STUART MCFETRIDGE; Fiscal Year: 2013
    ..the Federal research initiative to develop clinically superior treatment options for those suffering with severe TMD. In severe cases of damage or internal derangement (ID) the disc is surgically removed, unfortunately current ..
  34. Functional Interactions Between Peripheral P2X3 and TRP Channels
    JAMI LYNN SALOMAN; Fiscal Year: 2012
    ..Myofascial pain conditions, including those associated with temporomandibular joint and muscle disorder (TMD) affect millions of people...
  35. Sleep Bruxism and Central Sensitization in Myofascial Face Pain
    Karen G Raphael; Fiscal Year: 2011
    The pathogenesis of myofascial face pain (MFP), the most prevalent type of temporomandibular disorder (TMD), remains controversial. One of the key controversies concerns the role of sleep bruxism (SB)...
  36. Polymer gel to treat TMJ pain
    ALBERT PRESCOTT; Fiscal Year: 2004
    ..Currently the NIH recommends that minimally invasive procedures be used to treat TMJ disorders (TMD). Despite this, there are few minimally invasive therapies available to TMD patients or the doctors who treat them...
  37. Brainstem Mechanisms of Craniofacial Muscle Pain
    JIN RO; Fiscal Year: 2006
    ..and persist has hampered our ability to understand the underlying pathophysiology, and to diagnose and treat TMD and other masticatory disorders...
  38. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..As many as 60% of patients with temporomandibular disorder (TMD) also report symptoms of abdominal pain consistent with irritable bowel syndrome (IBS), but the underlying ..
  39. ANDREA G NACKLEY NEELY; Fiscal Year: 2014
    ..by applicant): Complex persistent pain conditions, such as fibromyalgia (FM) and temporomandibular disorder (TMD), are ineffectively treated because the underlying molecular mechanisms remain largely unknown...
  40. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
    ..the venus fly trap module (VFTM) of hT1R2, the cysteine-rich domain (CRD) of hT1R3 and the transmembrane domain (TMD) of hT1R3...
  41. Fredric S Cohen; Fiscal Year: 2016
    ..Chimera experiments strongly suggest the transmembrane domain (TMD) as the region of the fusion protein that confers voltage sensitivity...
  42. Identification of Altered Molecular Signature of Down Syndrome iPS Cells
    Marcelo Bento Soares; Fiscal Year: 2010
    ..As many as 10% of newborns with DS show evidence of transient myeloproliferative disorder (TMD), a disease in which megakaryocyte precursor cells proliferate abnormally...
  43. Brittney A Manvilla; Fiscal Year: 2014
    ..account for 5% of all integral membrane proteins and are characterized by a single carboxyl transmembrane domain (TMD) and a cytosolic-facing N-terminus...
  44. Eden R Martin; Fiscal Year: 2016
    ..that underlie susceptibility to one or more common persistent pain syndromes including temporomandibular disease (TMD), TMD with widespread pain, sciatica, post-herpetic neuralgia (PHN), neuropathic pain after spinal cord injury (SCI)..
  45. An ontology for pain and related disability, mental health and quality of life.
    WERNER M CEUSTERS; Fiscal Year: 2012
    ..able to answer by merging these datasets is how patho-anatomy and pathophysiology - in this case in the context of TMD and orofacial pains - have an impact on pain-related disablement and quality of life...
  46. John D Crispino; Fiscal Year: 2016
    ..predisposed to leukemia, with an estimated 1 in 10 newborns exhibiting transient myeloproliferative disorder (TMD) and 1 in 500 DS children developing acute megakaryocytic leukemia (AMKL) by the age of five...
  47. Basil Rapoport; Fiscal Year: 2014
    ..The hinge must also stabilize the position of the LRD relative to the membrane spanning TMD. The proposed studies on the least well understood TSHR NTD and hinge regions will provide novel insight into the ..
  48. Probing EBV-LMP-1's Transmembrane Activation Domain with Synthetic Peptide Antago
    HANG contact YIN; Fiscal Year: 2010
    ..Specifically, this proposal addresses the following Aims: 1) Can anti-TMD-1 peptides probes be developed that have high affinity and specificity for LMP-1's TMD-1? 2) Do identified ..
  49. HANG HUBERT YIN; Fiscal Year: 2016
    ..1 (LMP-1) was chosen as a model system to test this technology because of the essential role of its multi-spanning TMD in activation of signaling and its clinical relevance, particularly to lymphoid malignancies and ..
  50. Estrogen Receptor Beta Regulation of Mandibular Condylar Growth
    Sunil Wadhwa; Fiscal Year: 2013
    ..by estrogen and mechanical loading will aid in the understanding of diseases of the temporomandiblar joint (TMD), which have a predilection for women between the ages of 18 and 45, and may also lead to new approaches to joint ..
  51. Jonathan M Blagburn; Fiscal Year: 2015
    ..The third aim is to test whether increasing or knocking down expression of the En target Connectin, a member of the conserved LRR superfamily of adhesion molecules, alters axon guidance or glomerulus positioning...
  52. ALLOSTERIC TRANSITION IN LACTOSE REPRESSOR PROTEIN
    Kathleen Matthews; Fiscal Year: 2009
    ..We recently used targeted molecular dynamics simulation (TMD) to predict an atomic-level allosteric pathway that is concordant with the large library of experimental data on ..
  53. JAMIE KATHLEEN SCOTT; Fiscal Year: 2015
    ..Our preliminary work has shown that the gp41 transmembrane domain (TMD) is required for the full exposure of the MPER, since its replacement with the TMD from another membrane protein, ..
  54. Kari Stefansson; Fiscal Year: 2016
    ..will study large cohorts of phantom tooth pain (persistent dento-alveolar pain (PDAP)), temporomandibular disorder (TMD), and post-mastectomy pain syndrome...
  55. Nonstructural 4B protein and hepatitis C virus replication complex
    Kouacou V Konan; Fiscal Year: 2011
    ..Based on our current findings, we propose that: i) The TMD helices are engaged in intra/intermolecular interactions, thus contributing to NS4B structure and function, ii) The ..
  56. Refining Diagnostic Criteria of a Pain Disorder: Vulvar Vestibulitis Syndrome
    Denniz A Zolnoun; Fiscal Year: 2010
    ..g., temporomandibular disorder, TMD)...
  57. Bruce S Weir; Fiscal Year: 2016
    ..This hypothesis is based on our studies of temporomandibular disorder (TMD) in the multi-site OPPERA project (Orofacial Pain, Prospective Evaluation and Risk Assessment;NIH/NIDCR U01-..
  58. CARL PETER BLOBEL; Fiscal Year: 2016
    ..Moreover, substitution of the ADAM17 transmembrane domain (TMD) domain with that from other integral membrane proteins abolished ADAM17 activation...
  59. Michael S Wolfe; Fiscal Year: 2014
    ..on the lumen/extracellular side by the membrane-tethered ?-secretase and then within the transmembrane domain (TMD) by ?-secretase, a membrane-embedded aspartyl protease complex that contains the multi-pass presenilin as the ..
  60. Eric Bair; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Temporomandibular disorder (TMD) ranks second only to headache as the clinical condition most likely to cause craniofacial pain and dysfunction in the U.S. population...
  61. MENSTRUAL CYCLE EFFECTS ON TMD PAIN AND OTHER SYMPTOMS
    Linda LeResche; Fiscal Year: 2002
    DESCRIPTION: Temporomandibular disorders (TMD's) are musculoskeletal pain conditions characterized by pain in the muscles of mastication and/or the temporomandibular joint...
  62. Pain Management in Temporomandibular Joint Disorders
    Jennifer Haythornthwaite; Fiscal Year: 2005
    ..of these interventions in reducing pain and improving function in persons with temporomandibular disorders (TMD)...
  63. The Role of the TM of T1R2 in Sweet Receptor Activation
    Marianna Max; Fiscal Year: 2009
    ..VFTM of hT1R3 (natural sugars), the cysteine-rich domain (CRD) of hT1R3 (brazzein) and the transmembrane domain (TMD) of hT1R3 (cyclamate and NHDC)...
  64. Modeling Sweet Protein-Receptor Interactions
    Meng Cui; Fiscal Year: 2010
    ..Transmembrane Domain (TMD) of T1R2 and T1R3 can be modeled based on the crystal structure of bovine rhodopsin...
  65. TRANSMEMBRANE DOMAINS IN MEMBRANE FUSION
    John Lenard; Fiscal Year: 2003
    Experiments are proposed to determine the role of the transmembrane domain (TMD) in membrane fusion...
  66. CARNITINE PALMITOYLTRANSFERASE I ISOFORM FUNCTION
    Tod Gulick; Fiscal Year: 2005
    ..OMM): CPT-IA and B 1 have N-terminal hybrid mito targeting/stop transfer signals with 2 transmembrane domains (TMD)...