tissue factor

Summary

Gene Symbol: tissue factor
Description: coagulation factor III, tissue factor
Alias: CD142, TFA, tissue factor, coagulation factor III (thromboplastin, tissue factor)
Species: human

Top Publications

  1. ncbi Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
    Joanne L Yu
    Henderson Research Centre, Experimental Thrombosis Research, McMaster University, Hamilton, ON, Canada L8V 1C3
    Blood 105:1734-41. 2005
  2. doi Predictive value of tissue factor bearing microparticles in cancer associated thrombosis
    Jeffrey I Zwicker
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Thromb Res 125:S89-91. 2010
  3. pmc Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
    T A Drake
    Department of Pathology, UCLA
    Am J Pathol 134:1087-97. 1989
  4. ncbi Tissue factor pathway inhibitor and the revised theory of coagulation
    G J Broze
    Division of Hematology, Washington University School of Medicine, Jewish Hospital, St Louis, Missouri 63110, USA
    Annu Rev Med 46:103-12. 1995
  5. ncbi The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
    D W Banner
    Pharma Division, F Hoffmann La Roche, Basle, Switzerland
    Nature 380:41-6. 1996
  6. ncbi The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution
    Y A Muller
    Department of Protein Engineering, Genentech, Inc South San Francisco, CA 94080, USA
    J Mol Biol 256:144-59. 1996
  7. ncbi Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic
    L Presta
    Department of Immunology, Genetech Inc, South San Francisco, CA 94080, USA
    Thromb Haemost 85:379-89. 2001
  8. ncbi The presence and release of tissue factor from human platelets
    Farooq A Siddiqui
    Center for Hemostasis and Thrombosis, Clinical and Research Laboratories, Florida Hospital Cancer Institute, 2501 North Orange Avenue, Suite 786, Orlando, FL 32804, USA
    Platelets 13:247-53. 2002
  9. ncbi Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets
    Ingrid Muller
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, 81377 Munchen, Germany
    FASEB J 17:476-8. 2003
  10. ncbi Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein
    Vladimir Y Bogdanov
    Division of Thrombosis Research, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Nat Med 9:458-62. 2003

Research Grants

  1. ANGARA KONETI RAO; Fiscal Year: 2016
  2. Fluorogenic Assays for Factor Vlla and Tissue Factor
    RICHARD JENNY; Fiscal Year: 2006
  3. Structure, Function &Genetics of Coagulation Factors
    Darrel W Stafford; Fiscal Year: 2013
  4. Fluorogenic Assays for Factor Vlla and Tissue Factor
    RICHARD JENNY; Fiscal Year: 2003
  5. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2012
  6. The Activation of Prothrombin
    Kenneth G Mann; Fiscal Year: 2011
  7. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
  8. Activation of encrypted tissue factor during thrombus formation in vivo
    CAMERON TRENOR; Fiscal Year: 2012
  9. George J Broze; Fiscal Year: 2016
  10. TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    Judith Hellman; Fiscal Year: 2010

Patents

  1. Fusionproteins with parts of immunoglobulins, their production and use

Detail Information

Publications396 found, 100 shown here

  1. ncbi Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
    Joanne L Yu
    Henderson Research Centre, Experimental Thrombosis Research, McMaster University, Hamilton, ON, Canada L8V 1C3
    Blood 105:1734-41. 2005
    b>Tissue factor (TF) is the primary cellular initiator of blood coagulation and a modulator of angiogenesis and metastasis in cancer...
  2. doi Predictive value of tissue factor bearing microparticles in cancer associated thrombosis
    Jeffrey I Zwicker
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Thromb Res 125:S89-91. 2010
    ..Elevations in circulating tissue factor bearing microparticles are associated with thrombosis in cancer patients...
  3. pmc Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
    T A Drake
    Department of Pathology, UCLA
    Am J Pathol 134:1087-97. 1989
    b>Tissue factor (TF), the primary cellular initiator of the coagulation protease cascade, is implicated in having important roles in hemostasis, thrombogenesis, inflammation, and the cellular immune response, although the cytologic ..
  4. ncbi Tissue factor pathway inhibitor and the revised theory of coagulation
    G J Broze
    Division of Hematology, Washington University School of Medicine, Jewish Hospital, St Louis, Missouri 63110, USA
    Annu Rev Med 46:103-12. 1995
    b>Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation...
  5. ncbi The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
    D W Banner
    Pharma Division, F Hoffmann La Roche, Basle, Switzerland
    Nature 380:41-6. 1996
    Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation...
  6. ncbi The crystal structure of the extracellular domain of human tissue factor refined to 1.7 A resolution
    Y A Muller
    Department of Protein Engineering, Genentech, Inc South San Francisco, CA 94080, USA
    J Mol Biol 256:144-59. 1996
    Exposure of blood to cells expressing tissue factor results in formation of a high-affinity complex with factor VIIa, initiating the extrinsic pathway of blood coagulation by the activation of factors IX and X...
  7. ncbi Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic
    L Presta
    Department of Immunology, Genetech Inc, South San Francisco, CA 94080, USA
    Thromb Haemost 85:379-89. 2001
    Blocking the cofactor function of human tissue factor may be beneficial in various coagulation-mediated diseases...
  8. ncbi The presence and release of tissue factor from human platelets
    Farooq A Siddiqui
    Center for Hemostasis and Thrombosis, Clinical and Research Laboratories, Florida Hospital Cancer Institute, 2501 North Orange Avenue, Suite 786, Orlando, FL 32804, USA
    Platelets 13:247-53. 2002
    b>Tissue factor (TF) is a transmembrane receptor for FVII that triggers blood coagulation. It is not normally exposed to circulating blood, but may be produced by endothelium and monocytes under pathological conditions...
  9. ncbi Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets
    Ingrid Muller
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, 81377 Munchen, Germany
    FASEB J 17:476-8. 2003
    Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significance and location of the intravascular TF is ..
  10. ncbi Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein
    Vladimir Y Bogdanov
    Division of Thrombosis Research, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Nat Med 9:458-62. 2003
    b>Tissue factor (TF) is an essential enzyme activator that forms a catalytic complex with FVII(a) and initiates coagulation by activating FIX and FX, ultimately resulting in thrombin formation...
  11. ncbi Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor
    Karin Carlsson
    IFM Department of Chemistry, Linkoping University, Linkoping, Sweden
    Eur J Biochem 270:2576-82. 2003
    Blood coagulation is triggered by the formation of a complex between factor VIIa (FVIIa) and its cofactor, tissue factor (TF)...
  12. ncbi Role of tissue factor in hemostasis, thrombosis, and vascular development
    Nigel Mackman
    The Scripps Research Institute, Department of Immunology, 10550 North Torrey Pines Road, La Jolla, Calif 92037, USA
    Arterioscler Thromb Vasc Biol 24:1015-22. 2004
    b>Tissue factor (TF) is best known as the primary cellular initiator of blood coagulation. After vessel injury, the TF:FVIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets...
  13. ncbi Signaling of the tissue factor coagulation pathway in angiogenesis and cancer
    Mattias Belting
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 25:1545-50. 2005
    ..Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the ..
  14. ncbi Raising the active site of factor VIIa above the membrane surface reduces its procoagulant activity but not factor VII autoactivation
    Emily K Waters
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 281:26062-8. 2006
    b>Tissue factor, the physiologic trigger of blood clotting, is the membrane-anchored protein cofactor for the plasma serine protease, factor VIIa...
  15. ncbi Human platelets synthesize and express functional tissue factor
    Olga Panes
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Blood 109:5242-50. 2007
    The source and significance of bloodborne tissue factor (TF) are controversial. TF mRNA, protein, and TF-dependent procoagulant activity (PCA) have been detected in human platelets, but direct evidence of TF synthesis is missing...
  16. pmc Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    Patricia Redecha
    Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 110:2423-31. 2007
    ..In this study, we analyzed the role of the procoagulant molecule tissue factor (TF) in a mouse model of aPL antibody-induced pregnancy loss...
  17. pmc Inhibition of tissue factor signaling suppresses tumor growth
    Henri H Versteeg
    Department of Immunology, SP258, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:190-9. 2008
    Coagulation activation by tissue factor (TF) is implicated in cancer progression, cancer-associated thrombosis and metastasis. The role of direct TF signaling pathways in cancer, however, remains incompletely understood...
  18. ncbi Suppression of HUVEC tissue factor synthesis by antisense oligodeoxynucleotide
    Alick C Stephens
    King s College London, Department of Asthma, Allergy and Respiratory Science, 5th Floor Thomas Guy House, Guy s Hospital, London SE1 9RT, UK
    Thromb Res 122:99-107. 2008
    b>Tissue factor (TF) is an important regulator and effector molecule of coagulation...
  19. ncbi Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer
    Elena M Egorina
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Blood 111:1208-16. 2008
    Unlike unanimous opinion on tissue factor (TF) expression in monocytes, the quest for TF presence in granulocytes has been going on for decades...
  20. doi Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet-leukocyte aggregates
    Marta Brambilla
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
    Arterioscler Thromb Vasc Biol 28:947-53. 2008
    ..The aim of this study was to investigate the expression of TF in PLA, in platelets, and in monocytes of acute coronary syndrome (ACS) patients compared to SA patients and healthy subjects (Controls)...
  21. pmc Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt Univ School of Medicine, T 1218 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 294:L874-81. 2008
    The alveolar compartment in acute lung injury contains high levels of tissue factor (TF) procoagulant activity favoring fibrin deposition...
  22. doi Tissue factor expression in blood cells
    Bjarne Østerud
    Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
    Thromb Res 125:S31-4. 2010
    ..It may be concluded that monocytes are the only blood cells that synthesize and express TF and which may be the only source for TF-induced thrombosis when the endothelium is intact...
  23. doi Endothelin-1 signaling promotes fibrosis in vitro in a bronchopulmonary dysplasia model by activating the extrinsic coagulation cascade
    Konstantinos Kambas
    First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis 68100, Greece
    J Immunol 186:6568-75. 2011
    ..We observed a higher number of neutrophils expressing tissue factor (TF) in bronchoalveolar lavage fluid (BALF) from infants with BPD than from those with uncomplicated ..
  24. pmc Effect of tissue factor deficiency on mouse and tumor development
    J R Toomey
    Division of Hematology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:6922-6. 1997
    Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis...
  25. ncbi Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner
    E Biro
    Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    J Thromb Haemost 1:2561-8. 2003
    ..To what extent these microparticles contribute to coagulation in vivo is unknown...
  26. ncbi Tissue factor and tissue factor pathway inhibitor levels in trophoblast cells: implications for placental hemostasis
    Anat Aharon
    Rambam Medical Center, Haifa, 31096, Israel
    Thromb Haemost 92:776-86. 2004
    ..The aim of this study was to evaluate the levels of tissue factor (TF) and its inhibitors, tissue factor pathway inhibitor (TFPI, TFPI-2), in STB model within hemostatic and ..
  27. ncbi Tissue factor activity in whole blood
    Saulius Butenas
    University of Vermont, Department of Biochemistry, Given Building, 89 Beaumont Ave, Burlington, VT 05405 0068, USA
    Blood 105:2764-70. 2005
    b>Tissue factor (TF) is an integral membrane protein essential for hemostasis...
  28. pmc Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury
    Patricia Redecha
    Department of Medicine, Weill Medical College at Cornell University, New York, NY, USA
    Blood 113:4101-9. 2009
    ..CBA/J mice) that shares features with human recurrent miscarriage and fetal growth restriction, we identified tissue factor (TF) as an essential participating factor in placental and fetal injury...
  29. doi Coagulation and fibrinolysis related cytokine imbalance in preeclampsia: the role of placental trophoblasts
    Yin Cheng Teng
    Department of Obstetrics and Gynecology, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, China
    J Perinat Med 37:343-8. 2009
    ..Our objective was to determine the relationship of blood coagulation related factors in placental tissue and peripheral blood in preeclamptic and normal pregnancies...
  30. pmc Tissue factor in coagulation: Which? Where? When?
    Saulius Butenas
    Department of Biochemistry, University of Vermont, 208 South Park Drive, Suite 2, Room 235A, Colchester, VT 05446, USA
    Arterioscler Thromb Vasc Biol 29:1989-96. 2009
    b>Tissue factor (TF) is an integral membrane protein, normally separated from the blood by the vascular endothelium, which plays a key role in the initiation of blood coagulation...
  31. ncbi Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase: Possible signal transduction in tissue factor up-regulation
    Kazuya Murata
    Department of Molecular and Cellular Pathophysiology, Showa Pharmaceutical University, Higashi Tamagawa Gakuen, Machida, Tokyo 194 8543, Japan
    Biochim Biophys Acta 1762:835-43. 2006
    ..Shiga toxin) stimulation of macrophage-like THP-1 cells up-regulates the activity, antigen and mRNA levels of tissue factor (TF), a key cofactor of the coagulation-inflammation-thrombosis circuit...
  32. ncbi The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
    T F Zioncheck
    Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 267:3561-4. 1992
    b>Tissue factor (TF) is an integral membrane glycoprotein that serves as a cellular receptor and cofactor for the activation of the plasma protease factor VII...
  33. pmc Deceptive prothrombin and activated partial thromboplastin times in alcoholic cirrhosis
    P R Sirikonda
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103 2714, USA
    J Natl Med Assoc 88:306-9. 1996
    ..APTT), the MRT is performed with whole blood to ensure the role of blood cells and chemicals (particularly tissue factor, a potent procoagulant) in the coagulation process. Candidates for liver transplantation (n = 11) were studied...
  34. ncbi Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts
    O A Fadeeva
    National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia
    Biochemistry (Mosc) 75:734-43. 2010
    A method for transmembrane protein thromboplastin (tissue factor) immobilization on polystyrene surface is described. Tissue factor is the main activating factor launching the blood coagulation process...
  35. ncbi Enoxaparin, a low molecular weight heparin, inhibits platelet-dependent prothrombinase assembly and activity by factor-Xa neutralization
    F A Spencer
    Cardiovascular Thrombosis Research Center, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01685, USA
    J Thromb Thrombolysis 9:223-8. 2000
    ..with either unstable angina or non-ST segment elevation myocardial infarction (MI) receiving the LMWH enoxaparin (anti Xa:IIa ratio 3:1) to inhibit tissue factor-mediated thrombin generation and to inactivate platelet prothrombinase.
  36. ncbi Amplified anticoagulant activity of tissue factor-targeted thrombomodulin: in-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin
    Yi Xin Wang
    Berlex Biosciences, Richmond, California, USA
    Thromb Haemost 96:317-24. 2006
    b>Tissue factor (TF) exposure is a potent pro-thrombotic trigger that initiates activation of the coagulation cascade, while thrombomodulin (TM) is a potent anticoagulant protein that limits the extent of activation...
  37. ncbi Lipid rafts are necessary for tonic inhibition of cellular tissue factor procoagulant activity
    Dennis J Dietzen
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 103:3038-44. 2004
    A fraction of total cellular tissue factor procoagulant activity remains masked or "encrypted" in intact cells. Decryption of this activity partly involves the extracellular exposure of anionic phospholipids such as phosphatidylserine...
  38. ncbi Infant cardiopulmonary bypass: a procoagulant state
    J J Jaggers
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 68:513-20. 1999
    ..The induction of tissue factor and prothrombinase activity on endothelial cell membranes is a primary step in the activation of the extrinsic ..
  39. ncbi Activation of blood coagulation and fibrinolysis in Graves' disease
    F Marongiu
    Institute of Internal Medicine, University of Cagliari, Italy
    Horm Metab Res 23:609-11. 1991
    ..Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response...
  40. ncbi Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin
    J C Lormeau
    Haemobiology Research Department, Sanofi Recherche, Toulouse, France
    Thromb Haemost 76:5-8. 1996
    ..binding site of heparin to antithrombin on the antithrombin-mediated inactivation of factor VIIa bound to tissue factor. This effect was compared to the effect of unfractionated heparin...
  41. pmc Modified recalcification time (MRT): a sensitive cancer test? Review of the evidence
    C R Spillert
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103 2757, USA
    J Natl Med Assoc 87:687-92. 1995
    ..The hallmark of this test involves incorporating tissue factor (TF) in accurately assessing coagulability...
  42. pmc Nasal toxicity of cocaine: a hypercoagulable effect?
    R Patel
    Department of Otolaryngology, University of Medicine and Dentistry of New Jersey Newark, USA
    J Natl Med Assoc 92:39-41. 2000
    ..Our study revealed no connection between cocaine and enhanced platelet function or monocyte-released tissue factor. The coagulation process was unaffected by the addition of the drug, so we conclude that cocaine does not ..
  43. ncbi Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN
    C Van 't Veer
    Department of Biochemistry, University of Vermont, Burlington, Vermont 05405 0068, USA
    J Biol Chem 272:20721-9. 1997
    ..VLEIDEN on thrombin generation was evaluated in a reconstituted system using the purified components of the tissue factor (TF) pathway to thrombin and the components of the protein C pathway...
  44. ncbi The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action
    G J Broze
    Division of Hematology Oncology, Washington University School of Medicine, Jewish Hospital, St Louis, MO 63110
    Blood 71:335-43. 1988
    Blood coagulation is initiated when plasma factor VII(a) binds to its essential cofactor tissue factor (TF) and proteolytically activates factors X and IX. Progressive inhibition of TF activity occurs upon its addition to plasma...
  45. pmc Tumor necrosis factor-induced necrosis: a monocyte-mediated hypercoagulable effect
    C R Spillert
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103 2757, USA
    J Natl Med Assoc 87:508-9. 1995
    ..We hypothesize that TNF, by monocyte activation, produces the procoagulant tissue factor, thus leading to a state of hypercoagulability with resultant thrombotic vascular occlusion and tissue ..
  46. pmc Are hypertensives hypercoagulable?
    M A Miller
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103 2757
    J Natl Med Assoc 87:71-2. 1995
    ..The modified recalcification time (MRT) test, used to assess hypercoagulability, incorporates the role of tissue factor in coagulation by activating the monocyte with endotoxin to release latent tissue factor...
  47. pmc Effect of methylprednisolone on coagulation
    H B Pandit
    Department of Emergency Medicine, Bergen Regional Medical Center, 230 E Ridgewood Ave, Paramus, NJ 07562, USA
    J Natl Med Assoc 91:453-6. 1999
    ..This may suggest that the monocyte-stimulated release of the procoagulant tissue factor is inhibited by the corticosteroid, causing the blood to be relatively hypocoagulable.
  48. ncbi Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1
    H Ishii
    Department of Public Health, Showa Pharmaceutical University, Higashi Tamagawa Gakuen, Machida, Tokyo, Japan
    Thromb Haemost 84:712-21. 2000
    ..effect of verotoxin-1 (VT-1), which is released from Escherichia coli O157:H7, on endothelial expression of tissue factor (TF), a cofactor required to initiate blood coagulation...
  49. pmc Altered coagulability: an aid to selective breast biopsy
    C R Spillert
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103 2757
    J Natl Med Assoc 85:273-7. 1993
    ..Hypercoagulability can be measured by assessing tissue factor-mediated altered coagulability...
  50. pmc Expression of tissue factor pathway inhibitor by endothelial cells and platelets
    Susan A Maroney
    Blood Research Institute, Blood Center of Wisconsin, P O Box 2178, Milwaukee, WI 53201 2178, USA
    Transfus Apher Sci 38:9-14. 2008
    b>Tissue factor pathway inhibitor (TFPI) is a potent anticoagulant protein that abrogates the activity of the tissue factor-factor VIIa catalytic complex that activates blood coagulation in vivo...
  51. ncbi Tissue factor pathway inhibitor production by human proximal tubular epithelial cells in culture
    Toshiyuki Sugawara
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Zaifucho 5, Hirosaki 036, Japan
    Thromb Res 110:141-7. 2003
    ..It has been demonstrated that tissue factor (TF) is present in tubular epithelial cells of animal models of nephritis...
  52. ncbi Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor
    L C Petersen
    Novo Nordisk A S, Gentofte, Denmark
    Biochemistry 35:266-72. 1996
    ..report, we described the molecular cloning, expression, and partial characterization of a second human tissue factor pathway inhibitor (TFPI), which we designated as TFPI-2 [Sprecher, C. A., et al. (1994) Proc. Natl. Acad. Sci...
  53. pmc Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor
    C A Sprecher
    ZymoGenetics, Inc, Seattle, WA 98105
    Proc Natl Acad Sci U S A 91:3353-7. 1994
    ..of the extrinsic pathway of blood coagulation through its ability to inhibit factor Xa and factor VIIa-tissue factor activity...
  54. ncbi The tissue factor region that interacts with factor Xa in the activation of factor VII
    D Kirchhofer
    Department of Cardiovascular Research, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Biochemistry 40:675-82. 2001
    b>Tissue factor is the cell membrane-anchored cofactor for factor VIIa and triggers the coagulation reactions...
  55. ncbi Proteolytic activation of human factors IX and X by recombinant human factor VIIa: effects of calcium, phospholipids, and tissue factor
    Y Komiyama
    Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131
    Biochemistry 29:9418-25. 1990
    Previous studies indicated that factor VIIa, in complex with tissue factor, readily activates either factor X or factor IX in the presence of calcium ions...
  56. ncbi Effects of angiotensin converting enzyme and angiotensin II receptor inhibition on impaired fibrinolysis in systemic hypertension
    Y Erdem
    Department of Nephrology, Hacettepe University School of Medicine, Ankara, Turkey
    Am J Hypertens 12:1071-6. 1999
    ..and activity, tissue plasminogen activator (t-PA) antigen and activity, soluble thrombomodulin (sTM), and tissue factor pathway inhibitor (TFPI) before and after reaching the target blood pressure (<140/90 mm Hg) in 13 ..
  57. ncbi The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa
    M J Burgering
    Scientific Development Group, N V Organon, Oss, The Netherlands
    J Mol Biol 269:395-407. 1997
    b>Tissue Factor Pathway Inhibitor (TFPI) is a 36 kDa glycoprotein that helps maintain haemostasis by inhibiting Factor Xa and the Factor VIIa/Tissue Factor (TF) complex...
  58. doi Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor
    Egon Persson
    Haemostasis Biochemistry, Novo Nordisk A S, Novo Nordisk Park G8 2 76, DK 2760 Måløv, Denmark
    Thromb Res 123:171-6. 2008
    ..protein disulfide isomerase (PDI) stimulates factor X (FX) activation by factor VIIa (FVIIa) bound to soluble tissue factor (sTF) in a purified system and that PDI may be responsible for activating cellular tissue factor (TF) and ..
  59. pmc Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant
    Madhu S Bajaj
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 286:4329-40. 2011
    b>Tissue factor pathway inhibitor-2 (TFPI-2) inhibits factor XIa, plasma kallikrein, and factor VIIa/tissue factor; accordingly, it has been proposed for use as an anticoagulant...
  60. ncbi The regulation of the factor VII-dependent coagulation pathway: rationale for the effectiveness of recombinant factor VIIa in refractory bleeding disorders
    C van't Veer
    Department of Biochemistry, University of Vermont, Burlington, USA
    Semin Thromb Hemost 26:367-72. 2000
    ..b>Tissue factor acts as a receptor and activator of preexistent but virtually inactive two-chain plasma factor VIIa...
  61. ncbi Cytokines and hemostasis
    G Grignani
    Department of Internal Medicine and Medical Therapy, Institute for Medical Care Città di Pavia, Viale Parco Vecchio, 27, 27100 Pavia, Italy
    Haematologica 85:967-72. 2000
    ..The purpose of this review is to underline the most significant progresses recently achieved in this rapidly growing area...
  62. ncbi Characterization of functionally important regions of tissue factor by using monoclonal antibodies
    T Ito
    Department of Molecular Biology on Genetic Disease, Mie University School of Medicine
    J Biochem 114:691-6. 1993
    b>Tissue factor is a cellular membrane glycoprotein that acts as a cofactor for Factor VIIa-catalyzed activation of Factors X and IX in the extrinsic blood coagulation pathway...
  63. ncbi Recombinant human factor VIIa-induced alterations in tissue factor and thrombomodulin in patients with advanced liver cirrhosis
    David H Van Thiel
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois, USA
    J Gastroenterol Hepatol 20:882-9. 2005
    ..The aim of the present study was to investigate the consequences of rhFVIIa in individuals with advanced liver disease in an attempt to understand the mechanism of action of rhFVIIa in this unique population...
  64. ncbi Inhibition of arterial thrombosis by a soluble tissue factor mutant and active site-blocked factors IXa and Xa in the guinea pig
    J Himber
    Preclinical Research Department, F Hoffman La Roche Ltd, Basel, Switzerland
    Thromb Haemost 85:475-81. 2001
    The substrate recognition region of tissue factor contains two residues, Lys165 and Lys166, which are important for macromolecular substrate activation by the tissue factor:factor VIIa complex...
  65. ncbi Cellular effects of heparin on the production and release of tissue factor pathway inhibitor in human endothelial cells in culture
    C Lupu
    Vascular Biology Laboratory, Weston Centre for Experimental Research, Thrombosis Research Institute, London, United Kingdom
    Arterioscler Thromb Vasc Biol 19:2251-62. 1999
    b>Tissue factor pathway inhibitor (TFPI), the major downregulator of procoagulant activity of the tissue factor-factor VIIa complex (TF. FVIIa), is synthesized and constitutively secreted by endothelial cells (ECs)...
  66. ncbi Sensitive determination of N-terminal prolyl peptides by high-performance liquid chromatography with laser-induced fluorescence detection
    M Ishibashi
    Division of Drugs, National Institute of Health Sciences, Tokyo, Japan
    J Chromatogr A 661:105-12. 1994
    ..1% trifluoroacetic acid (TFA)...
  67. pmc Modified recalcification time: a global coagulation screening test
    C R Spillert
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07103 2757
    J Natl Med Assoc 85:611-6. 1993
    ..the contribution of all the circulating cellular and chemical mediators, including the important but neglected tissue factor, to coagulation is described...
  68. ncbi Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor
    B B Sorensen
    Vessel Wall Biology, Health Care Discovery, Novo Nordisk A S, Niels Steensens Vej 1, DK 2820 Gentofte, Denmark
    J Biol Chem 272:11863-8. 1997
    Recent studies showed that the administration of active site-inhibited factor VIIa blocked factor VIIa/tissue factor-induced fibrin and thrombus formation in ex vivo and in vivo model systems...
  69. ncbi Localization of tissue factor pathway inhibitor to lipid rafts is not required for inhibition of factor VIIa/tissue factor activity
    Dennis J Dietzen
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Thromb Haemost 89:65-73. 2003
    b>Tissue factor pathway inhibitor (TFPI) abrogates coagulation initiated by the factor VIIa/tissue factor catalytic complex...
  70. ncbi Fibronectin-adherent monocytes express tissue factor and tissue factor pathway inhibitor whereas endotoxin-stimulated monocytes primarily express tissue factor: physiologic and pathologic implications
    M S Bajaj
    Department of Medicine, David Geffen School of Medicine, and UCLA Orthopedic Hospital, Los Angeles, CA 90095 1690, USA
    J Thromb Haemost 5:1493-9. 2007
    Monocytes are critical cells in initiating physiologic and/or pathologic tissue factor (TF)-induced intravascular and extravascular coagulation...
  71. ncbi Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases
    A Apffel
    Bay Analytical Operation, Hewlett-Packard Co, Palo Alto, CA 94304, USA
    J Chromatogr A 712:177-90. 1995
    ..of peptide mapping with electrospray liquid chromatography--mass spectrometry using trifluoroacetic acid (TFA) containing HPLC mobile phases...
  72. ncbi Coexpression of tissue factor and tissue factor pathway inhibitor by human monocytes purified by leukapheresis and elutriation. Response of nonadherent cells to lipopolysaccharide
    P Nguyen
    Laboratoire d Hematologie, Institut Federatif de Rescherche 53 Bimolécules, Universite de Reims Champagne Ardenne, France
    Transfusion 39:975-82. 1999
    ..isolate monocytes for cellular immunotherapy, it is not known whether the process of elutriation can stimulate tissue factor (TF) expression and therefore trigger coagulation in patients receiving these cell preparations...
  73. ncbi Preparative isolation of recombinant human insulin-like growth factor 1 by reversed-phase high-performance liquid chromatography
    C V Olson
    Department of Recovery Process Research and Development, Genentech Inc, South San Francisco, CA 94080
    J Chromatogr A 675:101-12. 1994
    ..high-performance liquid chromatography procedure using a 5-micron C18 column, an acetonitrile-trifluoroacetic acid (TFA) isocratic elution, and elevated temperature gives baseline resolution of the four species...
  74. ncbi Fibrinolytic/hemostatic variables in arterial hypertension: response to treatment with irbesartan or atenolol
    T K Makris
    Cardiology Department, Laikon General Hospital, University of Athens, Greece
    Am J Hypertens 13:783-8. 2000
    ..The plasma levels of plasminogen activator inhibitor-1 antigen, thrombomodulin, tissue factor pathway inhibitor antigen, fibrinogen, and factor XII were determined before and after 6 months of therapy...
  75. doi Tissue factor pathway inhibitor relates to fibrin degradation in patients with acute deep venous thrombosis
    Johannes J Sidelmann
    Institute of Public Health, University of Southern Denmark, Esbjerg, Denmark
    Blood Coagul Fibrinolysis 19:405-9. 2008
    Reduced concentration of tissue factor pathway inhibitor is a risk factor for development of deep venous thrombosis, whereas elevated concentrations of tissue factor pathway inhibitor are observed in patients with acute myocardial ..
  76. ncbi Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography
    Lemonia Valianou
    Ormylia Art Diagnosis Center, Ormylia, 63071, Chalkidiki, Greece
    Anal Bioanal Chem 395:2175-89. 2009
    ..of five extraction methods which include the use of HCl (widely used extraction method), citric acid, oxalic acid, TFA and a combination of HCOOH and EDTA are compared on the basis of the (a) number, (b) relative quantities, measured ..
  77. ncbi High dose supplementation of RRR-alpha-tocopherol decreases cellular hemostasis but accelerates plasmatic coagulation in type 2 diabetes mellitus
    P Ferber
    German Diabetes Research Institute at the Heinrich-Heine University,
    Horm Metab Res 31:665-71. 1999
    ..and a shortened INR time suggest extrinsic coagulation activation, possibly by induction of a leukocyte tissue factor dependent mechanism...
  78. ncbi Monocyte tissue factor levels in cancer patients
    B A Lwaleed
    University Department of Haematology Level F 827, South Academic Block, Southampton University Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom
    Saudi Med J 21:722-9. 2000
    The association between cancer and thromboembolic disease has been known for over a century. Increased tissue factor expression by endothelial cells, monocytes or macrophages is implicated...
  79. ncbi Increased D-dimer levels correlate with binding of activated protein C, but not tissue factor expression, on peripheral blood monocytes in cancer patients
    M R Nijziel
    Department of Hematology, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Hematol 64:282-6. 2000
    Monocyte tissue factor expression is supposed to play an important role in the hypercoagulability of blood in cancer patients...
  80. ncbi Rapid verification of disulfide linkages in recombinant human growth hormone by tandem column tryptic mapping
    J Lei
    Department of Chemistry, Purdue University, West Lafayette, IN 47907-1393, USA
    J Chromatogr A 808:121-31. 1998
    ..1% trifluoroacetic acid (TFA) with 1% acetonitrile (ACN) to ACN with 0.1% TFA and 5% water...
  81. ncbi Decidual cell-expressed tissue factor maintains hemostasis in human endometrium
    C J Lockwood
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York 10016, USA
    Ann N Y Acad Sci 943:77-88. 2001
    We showed that decidualized stromal cells of luteal phase and pregnant human endometrium express tissue factor (TF), the primary initiator of hemostasis, thereby suggesting a mechanism by which perivascular decidual cells can mitigate ..
  82. doi Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S22-33. 2009
    Reduced consumption of trans-fatty acids (TFA) is desirable to lower coronary heart disease (CHD) risk...
  83. ncbi Progestin-regulated expression of tissue factor in decidual cells: implications in endometrial hemostasis, menstruation and angiogenesis
    Frederick Schatz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, Room 335 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
    Steroids 68:849-60. 2003
    Expression of tissue factor (TF), the primary initiator of hemostasis via thrombin formation, is induced during progesterone (P4)-stimulated decidualization of human endometrial stromal cells (HESCs), and remains elevated in decidualized ..
  84. ncbi Analysis of the components of Lycopus europaeus L. in body fluids during metabolism studies. Comparison of capillary electrophoresis and high-performance liquid chromatography
    H Wojciechowski
    , , , Germany
    J Chromatogr A 717:261-70. 1995
    ..The best mobile phase for isocratic HPLC was 0.03% TFA-acetonitrile (82:18, v/v)...
  85. pmc Tissue factor-expressing monocytes inhibit fibrinolysis through a TAFI-mediated mechanism, and make clots resistant to heparins
    Fabrizio Semeraro
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Bari, Italy
    Haematologica 94:819-26. 2009
    ..However, the enhancement of thrombin generation by soluble tissue factor was reported to have no effect on plasma fibrinolysis and it is not known whether the same is true for cell-..
  86. ncbi Trifluoroacetylation potentiates the humoral immune response to halothane in the guinea pig
    K L Hastings
    Division of Antiviral Drug Products, U.S. Food and Drug Administration, Rockville, MD 20857, USA
    Immunopharmacol Immunotoxicol 17:201-13. 1995
    ..protein, followed by exposure to halothane, and examined for anti-halothane metabolite antibodies (anti-TFA antibodies)...
  87. doi Evidence of maternal platelet activation, excessive thrombin generation, and high amniotic fluid tissue factor immunoreactivity and functional activity in patients with fetal death
    Offer Erez
    Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 22:672-87. 2009
    ....
  88. ncbi Synthesis, radiolabeling and biological activity of peptide oostatic hormone and its analogues
    J Hlavacek
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic
    J Pept Res 50:153-8. 1997
    ..The amino-terminal protected pentapeptide acid 2f was prepared by a stepwise procedure from TFA.H-Ala-Pro-OMe using Boc-Pro-OH, Z-Asp(OtBu)-OSu and Boc-Tyr-OSu...
  89. ncbi Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces
    Julie A Oliver
    Duke University and the Durham VA Medical Hospital, Durham, NC, USA
    Blood 100:539-46. 2002
    ..We have examined the activity of activated protein C in several tissue factor-initiated models of coagulation...
  90. ncbi Analysis of residual trifluoroacetic acid in a phosphate-buffered saline matrix by ion chromatography with suppressed conductivity detection
    P N Fernando
    Pharmacia Corporation, Skokie, IL 60077, USA
    J Chromatogr A 920:155-62. 2001
    ..from mice and incubated in a cocktail containing cell culture media and high levels of trifluoroacetic acid (TFA)...
  91. ncbi A comprehensive study on hemostasis in CAPD patients treated with erythropoietin
    Jolanta Malyszko
    Department of Nephrology and Internal Medicine, Bialystok University School of Medicine, Bialystok, Poland
    Perit Dial Int 22:582-92. 2002
    ..Platelets and tissue factor (TF) play a major role in plug formation...
  92. ncbi Positional analysis of triacylglycerols from bovine adipose tissue lipids varying in degree of unsaturation
    S B Smith
    CSIRO, Division of Food Science and Technology, Brisbane Laboratory, Tingalpa, Queensland, Australia
    Lipids 33:197-207. 1998
    ..protected cottonseed oil (PUFA); and a grain-based diet that resulted in high contents of trans fatty acids (TFA). Treatment groups produced in Japan (MUFA2 and MUFA3) were diets of unknown composition fed for over 300 d...
  93. ncbi Consumption of trans fats and estimated effects on coronary heart disease in Iran
    D Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur J Clin Nutr 61:1004-10. 2007
    ..To investigate the consumption of industrial trans-fatty acids (TFAs) in Iranian homes and the proportion of coronary heart disease (CHD) events in Iran attributable to such intake...
  94. ncbi Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2
    C N Rao
    Department of Dermatology, Northwestern University School of Medicine, Chicago, Illinois 60611 3008, USA
    Arch Biochem Biophys 335:82-92. 1996
    ..33-kDa inhibitor from SV-40 transformed human skin fibroblasts (t12FB) is identical to a recombinant trypsin/tissue factor pathway inhibitor called TFPI-2 from placenta...
  95. pmc The effects of continuous venovenous hemofiltration on coagulation activation
    Catherine S C Bouman
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, PO 22660, 1100 DD Amsterdam, The Netherlands
    Crit Care 10:R150. 2006
    ..to investigate whether CVVH using cellulose triacetate filters causes activation of the contact factor pathway or of the tissue factor pathway of coagulation. In contrast to previous studies, CVVH was performed without anticoagulation.
  96. ncbi Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plas
    Y Liu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Arch Biochem Biophys 370:112-8. 1999
    Human tissue factor pathway inhibitor-2 (TFPI-2)/matrix-associated serine protease inhibitor (MSPI), a Kunitz-type serine protease inhibitor, inhibits plasmin, trypsin, chymotrypsin, plasma kallikrein, cathepsin G, and factor VIIa-tissue ..
  97. ncbi Replacing trans fat: the argument for palm oil with a cautionary note on interesterification
    K C Hayes
    Foster Biomedical Res Lab, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    J Am Coll Nutr 29:253S-284S. 2010
    To replace dietary trans fatty acids (TFA), two practical options exist: revert to a natural saturated fat without cholesterol (most likely palm oil or its fractions) or move to a newer model of modified fat hardened by ..
  98. pmc Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities
    G Archipoff
    Centre Regional de Transfusion Sanguine, INSERM U 311, Strasbourg, France
    Br J Pharmacol 109:18-28. 1993
    ..cyclic GMP (db cyclic GMP) and 3-isobutyl-l-methyl-xanthine (IBMX) were investigated on the expression of tissue factor and thrombomodulin activities on the surface of human saphenous vein endothelial cells (HSVEC) in culture. 2...
  99. ncbi The role of tissue factor and P-selectin in the procoagulant response that occurs in the first month after on-pump and off-pump coronary artery bypass grafting
    Alessandro Parolari
    Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, Milan, Italy
    J Thorac Cardiovasc Surg 130:1561-6. 2005
    ..of postoperative prothrombotic state, in this study we evaluated plasma, monocyte-bound, and platelet-bound tissue factor expression, as well as platelet and soluble P-selectin expression, up to 1 month after off-pump and on-pump ..
  100. ncbi Enhancement of lipoprotein lipase activity by tissue factor pathway inhibitor
    M Mukherjee
    Thrombosis Research Institute, Chelsea, London, UK
    Thromb Haemost 82:1648-51. 1999
    The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described...
  101. ncbi Chromatographic purification and characterization of B-phycoerythrin from Porphyridium cruentum. Semipreparative high-performance liquid chromatographic separation and characterization of its subunits
    R Bermejo
    Department of Physical and Analytical Chemistry, Jaen University, E.U.P. of Linares, Spain
    J Chromatogr A 917:135-45. 2001
    ..05% trifluoroacetic acid (TFA) in water and 0.05% TFA in acetonitrile...

Research Grants66

  1. ANGARA KONETI RAO; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Activation of the tissue factor (TF) pathway of blood coagulation is associated with increased blood thrombogenicity and increases in markers of blood coagulation levels may in part explain the high ..
  2. Fluorogenic Assays for Factor Vlla and Tissue Factor
    RICHARD JENNY; Fiscal Year: 2006
    Factor VIIa and tissue factor (TF) are essential proteins for the initiation of blood coagulation. Blood coagulation is initiated when cryptic TF becomes exposed on the surface of vascular cells where it can bind circulating factor VIla...
  3. Structure, Function &Genetics of Coagulation Factors
    Darrel W Stafford; Fiscal Year: 2013
    ..Dr. Lee Pedersen's project 2 (Structures of complexes of tissue factor &VKD proteins) will use sophisticated molecular modeling techniques to extend known structural data: to ..
  4. Fluorogenic Assays for Factor Vlla and Tissue Factor
    RICHARD JENNY; Fiscal Year: 2003
    Factor Vlla and Tissue Factor (TF) are essential proteins for the initiation of blood coagulation. Blood coagulation is initiated when cryptic TF becomes exposed on the surface of vascular cells where it can bind circulating factor Vlla...
  5. Lipid Regulation of Thrombin Generation
    Barry R Lentz; Fiscal Year: 2012
    ..reactions involved in blood coagulation? Factor IXa with its cofactor VIIIa and factor VIIa with its cofactor tissue factor activate factor X to Xa. Factors IXa and VIIa are structurally similar to Xa, as is cofactor VIIIa to Va...
  6. The Activation of Prothrombin
    Kenneth G Mann; Fiscal Year: 2011
    ..Special emphasis will be focused on tissue factor from natural sources, protein S, and cellular contributions by platelets, monocytes and endothelial cells...
  7. Smooth Muscle Cell Tissue Factor and Cardiovascular Disease
    Mark B Taubman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tissue Factor (TF), the initiator of the coagulation cascade, plays a critical role in hemostasis and thrombosis...
  8. Activation of encrypted tissue factor during thrombus formation in vivo
    CAMERON TRENOR; Fiscal Year: 2012
    ..b>Tissue factor (TF) is required to initiate bloodcoagulation, thrombin formation and fibrin generation...
  9. George J Broze; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Tissue factor pathway inhibitor (TFPI) produces factor Xa (FXa)-dependent feedback inhibition of factor VIIa/tissue factor (FVIIa/TF)-induced coagulation. In humans, TFPI is expressed as two isoforms...
  10. TLR2 in Sepsis-Induced Coagulopathy, Endothelial Leak, and Pulmonary Dysfunction
    Judith Hellman; Fiscal Year: 2010
    ..EC will be treated with TLR2 agonists, and expression of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and plasminogen activator inhibitor type 1 (PAI-1) will be ..
  11. OXPAPC induction of Tissue Factor
    ALBERT PHILLIP OWENS; Fiscal Year: 2012
    ..b>Tissue factor (TF), the cellular activator of the clotting cascade, is induced when monocytes are exposed to oxidized ..
  12. Chad M Rienstra; Fiscal Year: 2014
    ..The primary focus of our studies is the membrane-bound complex of tissue factor and factor VIIa, the two-subunit enzyme responsible for triggering blood clotting in health and disease...
  13. FACTOR X ACTIVATION BY THE EXTRINSIC PATHWAY
    Sriram Krishnaswamy; Fiscal Year: 2006
    ..catalyses this reaction is composed of the serine proteinase, factor VIIa, and the integral membrane protein, tissue factor, that associate tightly on a cellular or phospholipid surface in a Ca2+-dependent reaction...
  14. TISSUE FACTOR IN BLOOD COAGULATION
    Yale Nemerson; Fiscal Year: 2002
    This program is directed toward the detailed understanding of tissue factor, the central initiator of blood coagulation...
  15. SUSAN ANTONE MARONEY; Fiscal Year: 2014
    ..Vascular factors appear to be a major component to dementia including those factors involving coagulation. Tissue Factor Pathway Inhibitor (TFPI) is the primary physiological inhibitor of tissue factor, the initiator of clotting ..
  16. The Biochemistry and Physiology of Platelet TFPI
    SUSAN ANTONE MARONEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tissue factor pathway inhibitor (TFPI) is the major inhibitor of the tissue factor/factor Vila (TF/Vlla) catalytic complex that initiates blood coagulation...
  17. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..We have demonstrated that both GBM tumor cells and its vascular endothelium express the cell surface receptor tissue factor (TF), a critical initiator of thrombosis, while the vasculature of the normal brain does not...
  18. Wolfram Ruf; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Tissue factor (TF), the initiator of the extrinsic coagulation pathway, is upregulated in cancer cells and the complex of TF with its ligand coagulation factor VIIa (FVIIa) contributes to cancer- ..
  19. Thiol Isomerases During Thrombus Formation
    Barbara C Furie; Fiscal Year: 2013
    ..released from platelets and endothelial cells, and their contribution to the modulation of function of proteins involved in thrombosis and hemostasis, including but not limited to GPIb, GPIIbIIIa and tissue factor.
  20. J Evan Sadler; Fiscal Year: 2016
    ..Project 4 will characterize new inhibitors of tissue factor and evaluate their efficacy in animal models of thrombosis, sepsis, HUS, and cancer progression...
  21. Mechanisms of Venous Thromboembolism in Cancer
    Nigel Mackman; Fiscal Year: 2012
    ..The overall goal of this proposal is to determine whether an association exists between tissue factor (TF) activity in circulating microparticles (MPs) and venous thrombosis in patients with pancreatic or colon ..
  22. A novel mechanism of coagulation in sickle cell disease
    JULIA BRITTAIN; Fiscal Year: 2012
    ..We now show that this binding directly induces monocyte tissue factor expression...
  23. ABD ALROOF HIGAZI; Fiscal Year: 2014
    ..Injured brain is highly procoagulant and TBI releases abundant tissue factor (TF), which leads locally to the activation of platelets and coagulation proteins...
  24. ERIK IAN TUCKER; Fiscal Year: 2014
    ..AXIMAB antibody 14E11 at limiting thrombus development under arterial shear flow conditions and during tissue factor initiated venous-type thrombosis...
  25. Alan E Mast; Fiscal Year: 2016
    Abstract Tissue Factor Pathway Inhibitor (TFPI) is an endothelial associated anticoagulant protein that directly inhibits the Tissue Factor-factor VIIa (TF-fVIIa) catalytic complex preventing intravascular thrombosis, disseminated ..
  26. James H Morrissey; Fiscal Year: 2016
    ..provided by applicant): Recent in vivo studies from several laboratories have challenged the paradigm that tissue factor is solely responsible for triggering blood clotting in thrombotic disease, by showing that blocking the ..
  27. Deranged Coagulation and Fibrinolytic Cascades in Idiopathic Pulmonary Fibrosis
    MITCHELL ALAN OLMAN; Fiscal Year: 2013
    ..Collectively, they demonstrate that tissue factor-dependent pro-coagulant activity is induced, and that the normal fibrinolytic activity is suppressed in the ..
  28. Molecular Recognition in Factor VIIa Induced Coagulation
    S Bajaj; Fiscal Year: 2005
    This application is based upon the conviction that activation of factor X by the tissue factor/factor VIIa (TF/VIIa) complex represents a key step in the initiation of coagulation by the extrinsic pathway...
  29. ALBERT PHILLIP OWENS III; Fiscal Year: 2014
    ..I still have much to learn from Dr. Mackman regarding the function of tissue factor in vascular disease...
  30. Cellular Determinants of Fibrin Structure and Stability
    Alisa S Wolberg; Fiscal Year: 2013
    RESEARCH AND RELATED Other Project Information 6. PROJECT SUMMARY/ABSTRACT Following injury, tissue factor (TF)-bearing cells are exposed to the blood, triggering blood clot formation...
  31. Scott L Diamond; Fiscal Year: 2016
    ..Aim 3: Using validated tissue factor microarray-flow chambers and microfluidic chambers, we will functionally phenotype thrombus production and ..
  32. FASEB SRC on Proteases in Hemostasis and Vascular Biology
    JAMES ANDREW HUNTINGTON; Fiscal Year: 2013
    ..adhesion;3) Fibrin(ogen)(olysis);4) Platelet signaling;5) von Willebrand Factor, TTP and proteases;6) Proteases and inhibitors in host defense;7) The O'Mics: Genomics/proteomics/degradomics/bloodomics;and, 8) Tissue Factor.
  33. Gadiparthi N Rao; Fiscal Year: 2016
    ..we observed that it activates Pyk2 and Syk, two non-receptor tyrosine kinases, and induces the expression of tissue factor, a clotting factor, and all of these molecules are involved in the mediation of inflammation...
  34. Mechanisms Linking Metastasis to Tumor Procoagulant and Innate Immunity
    Joseph S Palumbo; Fiscal Year: 2010
    ..A likely means available to tumor cells for engaging hemostasis is expression of tissue factor (TF), the cell-associated initiator of coagulation...
  35. Circulating Tissue Factor: Characterization and Interactions with Factor IX
    LISA DIANE WILSBACHER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tissue factor (TF) is an integral membrane glycoprotein that initiates the coagulation cascade after exposure to blood components...
  36. Emilio B Gonzalez; Fiscal Year: 2014
    ..expression of tissue factor (TF), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), ..
  37. Tissue factor expression in HIV disease - Implications for cardiovascular risk
    Nicholas Funderburg; Fiscal Year: 2013
    ..Monocytes from HIV infected patients have increased expression of tissue factor (TF) compared to levels found on monocytes from uninfected controls...
  38. Mechanism of Thrombosis in Heparin Induced Thrombocytopenia
    RAJ SUNDAR KASTHURI; Fiscal Year: 2013
    ..demonstrate that HIT antibody complexes can activate monocytes in vitro leading to the release of procoagulant tissue factor (TF) bearing microparticles (MPs)...
  39. Novel Platelet Functions in Sepsis and Venous Thromboembolism
    MATTHEW THOMAS RONDINA; Fiscal Year: 2013
    ..My preliminary data demonstrate that platelets isolated from sepsis patients produce new tissue factor (TF) mRNA and accelerate clot times...
  40. Tissue Factor splicing and pancreatic tumor progression: pilot studies
    VLADIMIR BOGDANOV; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We will ascertain whether (over)expression of alternatively spliced Tissue Factor (asTF) promotes pancreatic tumorigenesis, and whether a decrease in asTF expression suppresses pancreatic ..
  41. The Role of Tissue Factor-Factor VIIa-PAR2 Signaling in Breast Tumor Progression
    TROY MCEACHRON; Fiscal Year: 2010
    ..b>Tissue factor (TF) is a cell surface receptor that initiates the coagulation protease cascade...
  42. MOLECULAR BIOLOGY AND PHYSIOLOGY OF HUMAN FACTOR VII
    Steven Idell; Fiscal Year: 1992
    ..from trauma and cellular stimulation by a variety of biological agonists can initiate the expression of tissue factor, an obligatory integral membrane protein cofactor for factor VII activity, leading to hemostasis and ..
  43. NEW THERAPIES FOR HEMOPHILIA
    Nigel Key; Fiscal Year: 2004
    ..In Project 1 ("The Role of Tissue Factor in Hemophilia"), we will examine the biochemical basis for tissue factor encryption in vitro, and develop ..
  44. LIPOPROTEIN AND HEPARIN INTERACTIONS OF LACI
    WILLIAM NOVOTHY; Fiscal Year: 1991
    b>Tissue factor is increasingly considered to be the main initial stimulus for blood clotting in normal hemostasis and likely plays a major role in the pathological thrombosis associated with neoplasia, atherosclerosis and inflammatory ..
  45. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    ..In APAP- treated mice, tissue factor (TF) activates the coagulation cascade, resulting in activation of the thrombin receptor, protease-activated ..
  46. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    Alireza R Rezaie; Fiscal Year: 2010
    ..substrate, iii) to determine whether the first EGF domain of fX possesses an interactive site for tissue factor in the extrinsic Xase complex, and iv) to investigate the contribution of the post-translationally attached ..
  47. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
    ..vascular functions including smooth muscle contraction and migration, leukocyte-endothelial cell interactions, tissue factor expression, cell differentiation and cell proliferation...
  48. Sex Differences in Vascular Markers of Stroke Risk
    Cheryl D Bushnell; Fiscal Year: 2012
    ..Biological markers include tissue factor, matrix metalloproteinase-9 (MMP-9), vascular cell adhesion molecule-1 (VCAM-1), von Willebrand Factor (vWF), ..
  49. Progestin Effects on Uterine Hemostatis &Angiogenesis
    Charles Lockwood; Fiscal Year: 2011
    ..The resultant focal bleeding facilitates tissue factor-generated thrombin which exacerbates these angiogenic and inflammatory stimuli...
  50. EPCR, TAFI as Regulators of PMN/Endothelial Interaction
    Florea Lupu; Fiscal Year: 2009
    ..is beneficial or harmful? Changes in the expression and distribution of EPCR, TAFI, protein C, thrombomodulin, tissue factor (etc...
  51. Nigel Mackman; Fiscal Year: 2016
    ..The coagulation system is also activated by viral infections as part of the host defense response. Tissue factor (TF) and protease-activated receptor 1 (PAR-1) are induced in various cell types during viral infection...
  52. Mechanisms of GalTKO Lung Xenograft Injury
    Richard Pierson; Fiscal Year: 2009
    ..To test this hypothesis, a combination of genetic (GalTKO lungs expressing human tissue factor pathway inhibitor or decay accelerating factor) and pharmacologic approaches (specific platelet receptor, ..
  53. MMP1-PAR1 Signaling in Vascular Integrity During Sepsis
    Caitlin J Foley; Fiscal Year: 2013
    ..A key early event in sepsis is loss of vascular integrity, causing leakage of vascular fluid and increased tissue factor generation...
  54. Tissue Factor Mediated Fibrin Deposition in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..Our preliminary data identifies the alveolar epithelium as a potential source of tissue factor (TF), the major pro-coagulant stimulus in the alveolar compartment...
  55. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
    ..g. tissue factor and plasminogen activator inhibitor-1) through its ability to reduce NF?B activity...
  56. Karl A Nath; Fiscal Year: 2015
    ..involves impaired arterial blood flow and vascular reactivity, increased NF-?B and AP-1 activation, and/or tissue factor-dependent thrombosis...
  57. Julia E Geddings; Fiscal Year: 2016
    ..Importantly, these MPs contain the procoagulant protein tissue factor. We and others have shown that pancreatic tumors release tissue factor-positive MPs into the circulation in ..
  58. Circulating Age-related Lipid Mediators in Thrombosis
    Thomas M McIntyre; Fiscal Year: 2010
    ..Platelets have stored RNA that encodes tissue factor, and other relevant proteins, and appropriate stimuli causes activation-dependent splicing and translation ..
  59. Terrance G Cooper; Fiscal Year: 2015
    ..For example, an incomplete understanding of how mTorC1 regulates downstream events (increases Tissue Factor production which triggers the coagulation cascade) has raised high concern about late stent thrombosis in ..
  60. Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Bruce Furie; Fiscal Year: 2012
    ..In our pilot study to ascertain the association of thrombosis with a potential biomarker, tissue factor-bearing microparticles, the odds ratio for these microparticles in cancer patients with venous thromboembolic ..
  61. John H Griffin; Fiscal Year: 2015
    ..Project 3 (Ruf: Regulation of tissue factor (TF) procoagulant properties in thrombosis) will test the hypotheses that TF procoagulant activity on cells is ..
  62. Thrombus Formation In Vivo
    Bruce Furie; Fiscal Year: 2012
    ..In Project #1 entitled TISSUE FACTOR AND THE INITIATION OF THROMBUS FORMATION, Dr...
  63. Samuel A Wickline; Fiscal Year: 2016
    ..to dramatically enhance the local thrombogenic potential of unstable plaques by creating a hypercoagulant, tissue factor-rich milieu that is exposed by either plaque rupture or erosion, which results in vessel occlusion and hypoxic ..
  64. Venous Thrombosis in Cancer Outpatients: Prevention and Role of Tissue Factor
    Charles W Francis; Fiscal Year: 2012
    ..safety and efficacy of VTE prophylaxis in ambulatory cancer patients and also characterize the contribution of tissue factor to VTE. The proposal is focused on two specific aims...
  65. Purinergic Thromboregulation
    Simon C Robson; Fiscal Year: 2010
    ..compare accumulation of CD39, CD39L1 and CD39L3 in generated thrombi, with platelet sequestration, associated tissue factor and fibrin deposition. b) Contrast the impact of vascular Cd39L1 and/or Cd39L3 deletion vs...
  66. TFPI ALPHA AND TFPI BETA
    George Broze; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Tissue factor pathway inhibitor (TFPI) produces factor Xa (FXa)-dependent feedback inhibition of factor VIIa/tissue factor (FVIIa/TF)-induced coagulation. In humans, TFPI is expressed as two isoforms...

Patents1

  1. Fusionproteins with parts of immunoglobulins, their production and use
    Patent Number: EP0464533-A1; Date:1992-01-08