TINF2

Summary

Gene Symbol: TINF2
Description: TERF1 interacting nuclear factor 2
Alias: DKCA3, TIN2, TERF1-interacting nuclear factor 2, TERF1 (TRF1)-interacting nuclear factor 2, TRF1-interacting nuclear protein 2
Species: human

Top Publications

  1. pmc TIN2, a new regulator of telomere length in human cells
    S H Kim
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Genet 23:405-12. 1999
  2. ncbi A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
    Benjamin R Houghtaling
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 14:1621-31. 2004
  3. ncbi Identification of human Rap1: implications for telomere evolution
    B Li
    The Rockefeller University, New York, New York 10021, USA
    Cell 101:471-83. 2000
  4. ncbi Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers
    Mikako Yamada
    Department of Laboratory Diagnosis, and Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Anticancer Res 22:3303-7. 2002
  5. ncbi POT1 as a terminal transducer of TRF1 telomere length control
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 423:1013-8. 2003
  6. ncbi DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1320 York Avenue, New York, NY 10021, USA
    J Biol Chem 279:13241-8. 2004
  7. ncbi TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
    Jeffrey Zheng Sheng Ye
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 36:618-23. 2004
  8. ncbi PTOP interacts with POT1 and regulates its localization to telomeres
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 6:673-80. 2004
  9. pmc POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics and Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 18:1649-54. 2004
  10. ncbi TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:47264-71. 2004

Research Grants

  1. Nya D Nelson; Fiscal Year: 2015
  2. Jack D Griffith; Fiscal Year: 2015
  3. Telomeric Function in Aging Syndromes
    Jan Karlseder; Fiscal Year: 2010
  4. Determinants of Telomerase-Negative Cancer Cells
    Sahn Ho Kim; Fiscal Year: 2005
  5. Mechanism and Consequences of Telomere Dysfunction
    Zhou Songyang; Fiscal Year: 2012
  6. Toru Nakamura; Fiscal Year: 2016
  7. Sheila A Stewart; Fiscal Year: 2014
  8. Structure of the Telomere Shelterin Complex
    Ming Lei; Fiscal Year: 2012
  9. Model for Targeting Tankyrase1 in Cancer Therapy
    ZHENG SHENG YE; Fiscal Year: 2005
  10. BIOCHEMICAL GENETIC STUDIES OF CELL SURVIVAL PATHWAYS
    Zhou Songyang; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. pmc TIN2, a new regulator of telomere length in human cells
    S H Kim
    Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Genet 23:405-12. 1999
    ..We identified a novel human telomere-associated protein, TIN2, by interaction cloning using the telomeric DNA-binding-protein TRF1 as a bait...
  2. ncbi A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
    Benjamin R Houghtaling
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 14:1621-31. 2004
    ..Human telomeres are coated by the telomere repeat binding proteins TRF1 and TRF2, which are believed to function independently to regulate telomere length and protect chromosome ends, respectively...
  3. ncbi Identification of human Rap1: implications for telomere evolution
    B Li
    The Rockefeller University, New York, New York 10021, USA
    Cell 101:471-83. 2000
    It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast...
  4. ncbi Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers
    Mikako Yamada
    Department of Laboratory Diagnosis, and Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo Ku, Sapporo, 060 8543, Japan
    Anticancer Res 22:3303-7. 2002
    ..Several factors which regulate telomere length, TRF1 and 2, TIN2, tankyrase and Rap1, have been identified...
  5. ncbi POT1 as a terminal transducer of TRF1 telomere length control
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 423:1013-8. 2003
    ..telomere length is regulated by the TTAGGG-repeat-binding protein TRF1 and its interacting partners tankyrase 1, TIN2 and PINX1 (refs 5-9)...
  6. ncbi DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites
    Diego Loayza
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1320 York Avenue, New York, NY 10021, USA
    J Biol Chem 279:13241-8. 2004
    ..These data indicate that POT1 has a strong sequence preference for the human telomeric repeat tract and predict that POT1 can bind both the 3' telomeric overhang and the displaced TTAGGG repeats at the base of the t-loop...
  7. ncbi TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
    Jeffrey Zheng Sheng Ye
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 36:618-23. 2004
    ..Here we report that the inhibition of TRF1 by tankyrase is in turn controlled by a second TRF1-interacting factor, TIN2 (ref. 6)...
  8. ncbi PTOP interacts with POT1 and regulates its localization to telomeres
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 6:673-80. 2004
    ..ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12)...
  9. pmc POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics and Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 18:1649-54. 2004
    ..PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex...
  10. ncbi TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
    Jeffrey Zheng Sheng Ye
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:47264-71. 2004
    ..The TRF1 complex contains the TRF1 interacting partner, TIN2, as well as PIP1 and POT1 and regulates telomere-length homeostasis...
  11. pmc Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis
    Bong Kyeong Oh
    Department of Pathology, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea
    Am J Pathol 166:73-80. 2005
    The telomeric repeat-binding factor 1 (TRF1), TRF2, and the TRF1-interacting nuclear protein 2 (TIN2) are involved in telomere maintenance...
  12. pmc Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2
    Patrick Kaminker
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    J Cell Sci 118:1321-30. 2005
    ..show that the arrest of cell proliferation is accompanied by a reorganization of the telomere-associated protein, TIN2, into one to three large nuclear subdomains...
  13. ncbi Shelterin: the protein complex that shapes and safeguards human telomeres
    Titia de Lange
    The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:2100-10. 2005
    ..They are interconnected by three additional shelterin proteins, TIN2, TPP1, and Rap1, forming a complex that allows cells to distinguish telomeres from sites of DNA damage...
  14. pmc A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
    Matthew S O'Connor
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:11874-9. 2006
    ..telomeric complex (the mammalian telosome) that contains the six core proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 (formerly named PTOP/PIP1/TINT1) and mediates telomere end-capping and length control...
  15. pmc Protein requirements for sister telomere association in human cells
    Silvia Canudas
    Program in Molecular Pathogenesis and Department of Pathology, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    EMBO J 26:4867-78. 2007
    ..analysis to show that the telomeric proteins, TRF1 (an acceptor of PARsylation by tankyrase 1) and TIN2 (a TRF1 binding partner) each bind to the SA1 ortholog of the cohesin Scc3 subunit...
  16. doi A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
    Yong Chen
    Department of Biological Chemistry, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Science 319:1092-6. 2008
    ..We dissect the interactions of TRF1 and TRF2 with their shared binding partner (TIN2) and other shelterin accessory factors...
  17. pmc TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita
    Sharon A Savage
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 82:501-9. 2008
    ..Evidence favoring linkage was found at 2p24 and 14q11.2, and this led to the identification of TINF2 (14q11...
  18. pmc Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes
    Sahn Ho Kim
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Cell Biol 181:447-60. 2008
    ..One factor, TRF1-interacting protein 2 (TIN2), binds TRF1 and TRF2 directly and POT1 indirectly...
  19. pmc A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix
    Patrick G Kaminker
    Buck Institute for Age Research, Novato, California, USA
    Cell Cycle 8:931-9. 2009
    ..Six core proteins-TRF1, TRF2, TIN2, POT1, TPP1 and Rap1 (termed the telosome or shelterin complex)-regulate telomere structure and function...
  20. pmc TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
    Eladio Abreu
    Department of Biochemistry, University of Georgia, Athens, Georgia 30602, USA
    Mol Cell Biol 30:2971-82. 2010
    ..of the shelterin complex that is found at telomeres--TPP1 and the protein that tethers TPP1 to the complex, TIN2--results in a loss of telomerase recruitment...
  21. pmc TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase
    Dong Yang
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 286:23022-30. 2011
    ..Recently, multiple mutations in the gene encoding the telomeric protein TIN2 have been identified in DC patients with intact telomerase genes, but the molecular mechanisms underlying TIN2 ..
  22. pmc TIN2 stability is regulated by the E3 ligase Siah2
    Monica Bhanot
    Molecular Pathogenesis Program and Department of Pathology, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 32:376-84. 2012
    ..The central subunit TIN2, with binding sites to three subunits (TRF1, TRF2, and TPP1), is essential for stability and function of the ..
  23. pmc Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control
    Liuh Yow Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 47:839-50. 2012
    ..Here, we report that the canonical telomeric protein TIN2 is also a regulator of metabolism...
  24. pmc The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro
    Sahn Ho Kim
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    EMBO Rep 4:685-91. 2003
    Human TIN2 interacts with the telomeric-DNA-binding protein TRF1, suppresses telomere elongation in telomerase-positive cells, and may control telomere length by modulating telomere structure...
  25. ncbi Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins
    Dan Liu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:51338-42. 2004
    ..They interact with several other telomere regulators including TIN2, PTOP, POT1, and RAP1 to ensure proper maintenance of telomeres...
  26. pmc TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes
    Amanda J Walne
    Centre for Paediatrics, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Barts and The London Children s Hospital, London, United Kingdom
    Blood 112:3594-600. 2008
    ..complex (dyskerin, TERC, TERT, NOP10, and NHP2), and recently in one component of the shelterin complex TIN2 (gene TINF2)...
  27. ncbi TIN2 mediates functions of TRF2 at human telomeres
    Sahn Ho Kim
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 279:43799-804. 2004
    ..Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2, TANK1, TANK2, and hRAP1...
  28. pmc Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS
    Thalia Nittis
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Mol Cell Proteomics 9:1144-56. 2010
    ..Proteins enriched in cells expressing HA-FLAG-TIN2 were identified by label-free quantitative analysis of the FTICR mass spectra from different samples and ion trap ..
  29. ncbi Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres
    Zhou Songyang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Crit Rev Eukaryot Gene Expr 16:103-18. 2006
    ..Recently, the 6 telomeric proteins (TRF1, TRF2, POT1, TIN2, RAP1, and TPP1) were found to form a high-order complex...
  30. ncbi TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
    ..which binds telomeric single-stranded DNA (ssDNA), associates with multiple telomeric proteins (for example, TPP1, TIN2, TRF1, TRF2 and RAP1) to form the six-protein telosome/shelterin and other subcomplexes...
  31. doi Ataxia and pancytopenia caused by a mutation in TINF2
    Elena Tsangaris
    Cell Biology Program, Research Institute, University of Toronto, Toronto, ON, Canada
    Hum Genet 124:507-13. 2008
    ..845G>A (Arg282His) in TINF2, a gene recently reported to be mutated in a subset of patients with autosomal dominant dyskeratosis congenita...
  32. doi Developmental studies of Xenopus shelterin complexes: the message to reset telomere length is already present in the egg
    Dzeneta Vizlin-Hodzic
    University of Gothenburg, Department of Biomedicine, Medical Biochemistry and Cell Biology Division, P O Box 440, SE 405 30 Gothenburg, Sweden
    FASEB J 23:2587-94. 2009
    ..In vitro expression and biochemical characterization of the Xenopus shelterin proteins TRF1, TRF2, POT1, TIN2, RAP1, TPP1, and the shelterin accessory factor PINX1 indicate that all main functions of their human orthologs are ..
  33. ncbi Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2
    Sahn Ho Kim
    Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Genomics 81:422-32. 2003
    Telomere length is regulated by TRF1, which binds telomeric DNA, and TIN2, which binds TRF1. Laboratory mice (Mus musculus) have long telomeres, although a related mouse species, Mus spretus, has human-sized telomeres...
  34. pmc In vivo stoichiometry of shelterin components
    Kaori K Takai
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065 6399, USA
    J Biol Chem 285:1457-67. 2010
    ..TRF2 and Rap1 were present at 1:1 stoichiometry as were TPP1 and POT1. The abundance of TIN2 was sufficient to allow each TRF1 and TRF2 to bind to TIN2...
  35. pmc Targeted deletion reveals an essential function for the telomere length regulator Trf1
    Jan Karlseder
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 23:6533-41. 2003
    The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance...
  36. doi Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation
    Katherine T Etheridge
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:6935-41. 2008
    ..These three proteins are linked through either direct interactions or by the proteins TIN2 and TPP1...
  37. ncbi Importance of TRF1 for functional telomere structure
    Tomohiko Iwano
    Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Biol Chem 279:1442-8. 2004
    ..TRF1-deficient cells, abnormal telomere signals were observed, and TRF1-interacting telomere-binding factor, TIN2, lost telomeric association...
  38. doi Telomeric TuRF1 wars
    Shireen A Sarraf
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 18:167-8. 2010
    ..Work from Zeng et al. (2010) now reveals in atomic detail how a battle between the SCF(FBX4) ubiquitin ligase and the shelterin component TIN2 controls TRF1 abundance and telomere length homeostasis.
  39. ncbi Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas
    N Matsutani
    First Department of Pathology, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Pathobiology 69:219-24. 2001
    ..TRF1-interacting, ankyrin-related ADP-ribose polymerase (tankyrase) as well as TRF1-interacting nuclear protein 2 (TIN2)...
  40. ncbi Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells
    Koji Yamada
    Division of Laboratory Diagnosis, Sapporo Medical University School of Medicine, Japan
    Anticancer Res 22:1315-20. 2002
    ..Details of mechanisms regulating telomere length are poorly understood in human hematopoietic cells...
  41. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..In addition, proteins that bind along the length of the telomere (TRF1/TIN2/tankyrase in humans and Rap1/Rif1/Rif2 in budding yeast) are part of a negative feedback loop that regulates ..
  42. pmc Telomere maintenance and human bone marrow failure
    Rodrigo T Calado
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 111:4446-55. 2008
    ..by mutations in genes encoding components of telomerase or telomere-binding protein (TERT, TERC, DKC1, NOP10, or TINF2)...
  43. pmc LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection
    Samantha A Sheppard
    Department of Biological Sciences Hunter College, New York, NY 10065, USA
    Aging (Albany NY) 2:432-44. 2010
    ..TRIP6 could co-immunoprecipitate with POT1, TRF2 and TIN2 in human cells, arguing for association with the whole shelterin complex, and was detected at telomeres by ChIP...
  44. doi A child with severe form of dyskeratosis congenita and TINF2 mutation of shelterin complex
    Nazan Sarper
    Department of Pediatrics, Division of Pediatric Hematology, Medical Faculty Hospital of Kocaeli University, Kocaeli 41300, Turkey
    Pediatr Blood Cancer 55:1185-6. 2010
    ..After 30 months, transfusion support was required. TINF2 mutation was identified at the age of five and dyskeratosis congenita (DC) was confirmed...
  45. pmc Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
    Ok Hee Lee
    Severance Hospital Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, Seoul, Korea
    Mol Cell Proteomics 10:M110.001628. 2011
    ..action of members of the Telomere Interactome, built upon the six core telomeric proteins TRF1, TRF2, RAP1, TIN2, TPP1, and POT1...
  46. doi Tinman is a direct activator of midline in the Drosophila dorsal vessel
    Jae Ryeon Ryu
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada
    Dev Dyn 240:86-95. 2011
    ..Mutation of two Tinman binding sites (Tin1 and Tin2) reduces or abolishes cardiac expression in derivatives of the 1.7 kb fragment...
  47. doi Telomerase activation without shortening of telomeric 3'-overhang is a poor prognostic factor in human colorectal cancer
    Kensaku Kojima
    Department of Surgery, Graduate School of Biomedical Sciences, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan
    Cancer Sci 102:330-5. 2011
    ..The expression levels of eight TBP genes (TRF1, TRF2, TIN2, TANK1, TANK2, POT1, RAP1 and TPP1) were analyzed...
  48. pmc Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres
    Megan McKerlie
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Nat Commun 2:371. 2011
    ..by Cdk1 keeps TRF1 free of chromatin and this phosphorylation is associated with loss of telomere-bound TRF1 and TIN2, and a reduction in telomere heterochromatin...
  49. doi Successful treatment with rituximab and mycophenolate mofetil of refractory autoimmune hemolytic anemia post-hematopoietic stem cell transplant for dyskeratosis congenita due to TINF2 mutation
    Niall O'Connell
    Department of Haematology, Our Lady s Children s Hospital, Dublin, Ireland
    Pediatr Transplant 18:E22-4. 2014
    ..We report our experience of a child refractory to immunoglobulin and steroid therapy who required several infusions of rituximab and immunomodulatory therapy to obtain a clinically significant response...
  50. pmc Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring
    Amirah Abdul Rahman
    Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, Malaysia
    Oxid Med Cell Longev 2013:189129. 2013
    ..response (IL27RA), whereas response to stress (HSPA8), damage stimulus (XRCC6), and chromatin remodelling (TINF2) pathways were downregulated in octo/nonagenarians...
  51. pmc A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize
    Shigeyuki Tanaka
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    elife 3:e01355. 2014
    ..Here, we show that anthocyanin biosynthesis is induced by the virulence promoting secreted effector protein Tin2. Tin2 protein functions inside plant cells where it interacts with maize protein kinase ZmTTK1...
  52. pmc Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy
    Akshay Sharma
    Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky
    Pediatr Blood Cancer 61:2302-4. 2014
    ..2603A>G. Revesz syndrome, a subtype of dyskeratosis congenita (DC) caused by TINF2 mutation, combines marrow failure with exudative retinopathy, intracranial calcifications, and neurocognitive ..
  53. pmc Telomerase activation after recruitment in fission yeast
    Christine Anne Armstrong
    Chromosome Maintenance Group, UCL Cancer Institute, University College London, London WC1E 6DD, UK
    Curr Biol 24:2006-11. 2014
    ..Recent studies have demonstrated that the telomeric protein TPP1 and its binding protein TIN2 are key proteins for both telomerase recruitment and processivity in mammalian cells [5-7]...
  54. pmc Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1
    Hande Kocak
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 28:2090-102. 2014
    ..protein significantly compromises both telomerase recruitment and processivity, while the missense mutation in the TIN2-binding region of TPP1 is not as clearly deleterious to TPP1 function...
  55. pmc TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling
    Michal Zimmermann
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA Central European Institute of Technology, Masaryk University, Brno 625 00, Czech Republic
    Genes Dev 28:2477-91. 2014
    ..action using mouse conditional knockouts of BLM, TRF1, TPP1, and Rap1 in combination with expression of TRF1 and TIN2 mutants...
  56. pmc Three of a Kind: Genetically Similar Tsukamurella Phages TIN2, TIN3, and TIN4
    Zoe A Dyson
    La Trobe Institute of Molecular Sciences, Bendigo, Victoria, Australia
    Appl Environ Microbiol 81:6767-72. 2015
    Three Tsukamurella phages, TIN2, TIN3, and TIN4, were isolated from activated sludge treatment plants located in Victoria, Australia, using conventional enrichment techniques...
  57. pmc TINF2 Gene Mutation in a Patient with Pulmonary Fibrosis
    T W Hoffman
    Department of Pulmonology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, Netherlands
    Case Rep Pulmonol 2016:1310862. 2016
    ..The telomere gene TINF2 encodes an eponymous protein that is part of the shelterin complex, a complex involved in telomere protection and ..
  58. pmc Preferential extension of short telomeres induced by low extracellular pH
    Yuanlong Ge
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou 510006, China Collaborative Innovation Center of High Performance Computing, National University of Defense Technology, Changsha 410073, China Zhongshan Medical School, Sun Yat Sen University, Guangzhou 510006, P R China
    Nucleic Acids Res 44:8086-96. 2016
    ..After growth at pHe 6.8, the expression of telomerase, TRF1, TRF2 and TIN2 decreases, and the abundance of Cajal bodies decreases...
  59. pmc De novo assembly and characterization of the Chinese three-keeled pond turtle (Mauremys reevesii) transcriptome: presence of longevity-related genes
    Huazong Yin
    College of Life Science, Anhui Normal University, Provincial Key Lab of the Conservation and Exploitation Research of Biological Resources in Anhui, Wuhu, Anhui, China
    Peerj 4:e2062. 2016
    ..the transcriptome, including tert, tep1, and six shelterin complex proteins coding genes (trf1, trf2, tpp1, pot1, tin2 and rap1)...
  60. pmc Telomere status in chronic lymphocytic leukemia with TP53 disruption
    Romain Guieze
    CHU Clermont Ferrand, Hématologie Clinique, Clermont Ferrand, F 63003 EA 7283 CREaT, Universite d Auvergne, Clermont Ferrand, France
    Oncotarget 7:56976-56985. 2016
    ..Interestingly, low expression of POT1, TPP1 and TIN2 was also found in some patients with wild-type TP53 and had an adverse impact on progression-free survival after ..
  61. doi Retinal findings and a novel TINF2 mutation in Revesz syndrome: Clinical and molecular correlations with pediatric retinal vasculopathies
    Mrinali P Gupta
    a Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmic Genet . 2017
    ..Revesz syndrome is a telomere disorder in the dyskeratosis congenita (DKC) spectrum characterized by exudative retinopathy, bone marrow failure, neuroradiographic abnormalities, and integumentary findings...
  62. pmc Persistent telomere cohesion triggers a prolonged anaphase
    Mi Kyung Kim
    Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Pathology, New York University School of Medicine, New York, NY 10016
    Mol Biol Cell 25:30-40. 2014
    ..telomere cohesion, or by overexpression of proteins required to establish telomere cohesion, the shelterin subunit TIN2 and the cohesin subunit SA1...
  63. ncbi Telomere biology: a new player in the end zone
    Lorel Colgin
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
    Curr Biol 14:R901-2. 2004
    ..variously as PTOP, PIP1 or TINT1, this negative regulator of telomere length connects some of the key proteins already known to be present - TRF1, TIN2, POT1, and TRF2 - and adds even more complexity to telomere protein interactions.
  64. doi Structure prediction of binary pernitride MN2 compounds (M=Ca, Sr, Ba, La, and Ti)
    A Kulkarni
    Max Planck Institut fur Festkorperforschung, Heisenbergstr 1, 70569 Stuttgart, Germany
    Chem Asian J 8:743-54. 2013
    ..In particular, TiN2 should crystallize in a new structure type, TiN2-I.
  65. pmc Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome
    Zhong Deng
    Program in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:E3408-16. 2013
    ..in telomerase and the shelterin component telomeric repeat binding factor 1 (TRF1)-interacting nuclear factor 2 (TIN2)...
  66. pmc Cell cycle regulated phosphorylation of the telomere-associated protein TIN2
    Shuqun Yang
    Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, DUMC, Durham, North Carolina, United States of America
    PLoS ONE 8:e71697. 2013
    The protein TIN2 is a member of telomere-binding protein complex that serves to cap and protect mammalian chromosome ends...
  67. doi Study of differential effects of TGF-beta3/BMP2 on chondrogenesis in MSC cells by gene microarray data analysis
    Yunxia Sang
    School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China
    Mol Cell Biochem 385:191-8. 2014
    ..Based on the PPI network analysis, the genes of KIAA0101, NEDD4, and TINF2 were confirmed to be important on chondrogenesis...
  68. doi A quantitative telomeric chromatin isolation protocol identifies different telomeric states
    Larissa Grolimund
    1 EPFL Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, CH 1015 Lausanne, Switzerland 2 ISREC Swiss Institute fro Experimental Cancer Research at EPFL, CH 1015 Lausanne, Switzerland 3
    Nat Commun 4:2848. 2013
    ..short telomeres and detect increased density of SMCHD1 and LRIF1 and increased association of the shelterins TRF1, TIN2, TPP1 and POT1 with long telomeres...
  69. pmc Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood
    G S Sasa
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Clin Genet 81:470-8. 2012
    ..Mutations in a narrow segment of TINF2 exon 6 have been recognized to cause often-severe DC that is either sporadic or autosomal dominant...
  70. pmc Telomere length is associated with disease severity and declines with age in dyskeratosis congenita
    Blanche P Alter
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7231, USA
    Haematologica 97:353-9. 2012
    ..Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology...
  71. doi Lack of mutations of the telomerase RNA component in familial papillary thyroid cancer with short telomeres
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism, and Biochemistry, University of Siena, Siena, Italy
    Thyroid 22:363-8. 2012
    ..associated with mutations in the telomerase RNA component (TERC) gene or in the shelterin complex (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2) genes...
  72. doi Mutational analysis of telomere genes in BRCA1/2-negative breast cancer families with very short telomeres
    Kira Yanowsky
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Breast Cancer Res Treat 134:1337-43. 2012
    ..Most of the changes were non-coding variants and only nine corresponded to coding variants located in TPP1, TINF2, NHP2, TNKS, and RAD54B genes; although only two corresponded to coding missense changes leading to aminoacid ..
  73. pmc Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita
    Fabian Beier
    Telomere and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Blood 120:2990-3000. 2012
    ..A subset of patients, however, show mutations in the shelterin component TIN2, a TRF1-interacting protein, presenting a more severe phenotype and presence of very short telomeres despite normal ..
  74. pmc Telomere length is shorter in affected members of families with familial nonmedullary thyroid cancer
    Mei He
    Endocrine Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Thyroid 23:301-7. 2013
    ..Thus, the aim of this study was to determine whether telomere length and genes involved in maintaining telomere length are altered in FNMTC...
  75. doi Mitochondria and telomeres: the promiscuous roles of TIN2
    Lucas B Sullivan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Cell 47:823-4. 2012
    ..In this issue, Chen et al. (2012) demonstrate that the telomeric protein TIN2 can specifically localize to the mitochondria, where it can regulate metabolism and ROS production.
  76. pmc Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas
    Kimberly S Butler
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine Albuquerque, New Mexico, 87131, USA
    Cancer Med 1:165-75. 2012
    ..factor 1 and 2 (TRF1 and TRF2), protection of telomeres (POT1), and TRF1-interacting nuclear factor 2 (TIN2)...
  77. doi [Dyskeratosis congenita: an update]
    V Mialou
    Institut d hématologie et oncologie pédiatrique IHOP, 1, place Professeur J Renaut, 69008 Lyon, France
    Arch Pediatr 20:299-306. 2013
    ..Until now, 6 genes (DKC1, TERT, TERC, NOLA2, NOLA3, TINF2) have been identified in dyskeratosis congenita...
  78. ncbi Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)
    B Zhou
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    J Am Soc Nephrol 11:658-68. 2000
    ..the complete cDNA and predicted amino acid sequences of two human TIN-Ag mRNA species referred to as TIN1 and TIN2. Translation through the open reading frames of these clones indicates the presence of a signal peptide and ..
  79. ncbi The human TINF2 gene organisation and chromosomal localization
    T Simonsson
    Molecular Biotechnology, Lundberg Laboratory, P O Box 462, SE 405 30, Goteborg, Sweden
    Biochimie 83:433-5. 2001
    ..TIN2, the protein product of the human TINF2 gene, was recently identified as a negative regulator of telomere length...
  80. ncbi A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins
    Cecile Mignon-Ravix
    INSERM 491, Faculte de Medecine Timone, Marseille, France
    Eur J Hum Genet 10:107-12. 2002
    ..Using specific antibodies and immuno-FISH on unfixed metaphase chromosomes, we show that the proteins TRF2 and TIN2 (TIN2 interacts with TRF1) co-localise with the interstitial TTAGGG repeats...
  81. ncbi Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells
    Miguel A Rubio
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 277:28609-17. 2002
    ..Superinfection with retroviruses carrying wild-type or mutant forms of TIN2, a negative regulator of telomere length, created telomerase-positive, immortal populations with varying average ..
  82. ncbi Polypeptide components of telomere nucleoprotein complex
    A N Kuimov
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow 119899, Russia
    Biochemistry (Mosc) 69:117-29. 2004
    ..telomeres of humans and many model organisms contain a structure called a t-loop, which is maintained by TERF, TINF2, Pot1, and other proteins. Increase in TERF1 concentration prevents telomere elongation by telomerase...
  83. ncbi Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells
    Rumiana Bakalova
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    FEBS Lett 564:73-84. 2004
    ..by: alterations in telomeric associated proteins-overexpression of tankyrase and decreased amount of TRF1/Tin2, cell growth arrest of K-562 cells, reaching a plateau after 6 days treatment, and increased proliferating activity ..
  84. pmc Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway
    Y Jeffrey Chiang
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, 4B36, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cell Biol 24:6631-4. 2004
    b>TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism...
  85. ncbi Loss of hPot1 function leads to telomere instability and a cut-like phenotype
    Timothy Veldman
    Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 14:2264-70. 2004
    ..telomeric DNA binding proteins TRF1 and TRF2 through the bridging proteins PTOP (also known as PIP1 or TINT1) and TIN2. Disrupting either the DNA binding activity of hPot1 or its association with PTOP results in elongated telomeres, ..
  86. ncbi Genetic variation, nucleotide diversity, and linkage disequilibrium in seven telomere stability genes suggest that these genes may be under constraint
    Sharon A Savage
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
    Hum Mutat 26:343-50. 2005
    ..We surveyed common genetic variation in seven genes that are vital to telomere stability (TERT, POT1, TNKS, TERF1, TINF2, TERF2, and TERF2IP) and validated single nucleotide polymorphisms (SNPs) in four different ethnic groups (n=118 ..
  87. ncbi Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia
    Marcia Bellon
    Department of Microbiology, Immunology and Molecular Genetics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Int J Cancer 119:2090-7. 2006
    ..Transcriptional and posttranscriptional expression of telomere-binding proteins TRF1, TRF2, TIN2 and POT1, known to regulate telomere homeostasis and protection, were evaluated...
  88. ncbi Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference
    W Q Jiang
    Cancer Research Unit, Children s Medical Research Institute, Westmead, NSW, Australia
    Oncogene 26:4635-47. 2007
    ..required for APB formation: PML body-associated proteins, PML and Sp100; telomere-associated proteins, TRF1, TRF2, TIN2 and RAP1; and DNA repair proteins, MRE11, RAD50, NBS1 and 53BP1...
  89. pmc Telomere maintenance through spatial control of telomeric proteins
    Liuh Yow Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:5898-909. 2007
    The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a complex called the telosome/shelterin, which is required for telomere protection and length control...
  90. ncbi The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome
    Mohamed Salhab
    St George s University of London, Blackshaw Road, and The Princess Grace Hospital, London, SW17 OQT, UK
    Breast Cancer Res Treat 109:35-46. 2008
    ..These proteins include hTR, TRF1, TRF2, TANK1, TANK2, POT1, TIN2, EST1, and TEP...
  91. ncbi Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia
    Delphine Poncet
    Laboratoire de Biologie Moleculaire et de Cellule, Centre National de la Recherche Scientifique UMR5239, IFR128, Faculté de médecine Lyon Sud, Universite Lyon 1, Lyon, France
    Blood 111:2388-91. 2008
    ..out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, ..
  92. doi Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients
    Michael Kirwan
    Centre for Paediatrics, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Br J Haematol 144:771-81. 2009
    ..encode components of the telomerase complex (DKC1, TERC, TERT, NOP10 and NHP2), and telomere shelterin complex (TINF2), both important in telomere maintenance...
  93. pmc Advances in the understanding of dyskeratosis congenita
    Amanda J Walne
    Centre for Paediatrics, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Br J Haematol 145:164-72. 2009
    ..six genes which either encode components of the telomerase complex (DKC1, TERC, TERT, NOP10, NHP2) or shelterin (TINF2); these are important in the elongation and protection of the telomeric end, respectively...
  94. pmc Dyskeratosis congenita, stem cells and telomeres
    Michael Kirwan
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Biochim Biophys Acta 1792:371-9. 2009
    ..dyskerin, TERC, TERT, NOP10 and NHP2) or are part of the shelterin complex that protects the telomeric end (TIN2)...
  95. pmc GNL3L stabilizes the TRF1 complex and promotes mitotic transition
    Qubo Zhu
    Center for Cancer and Stem Cell Biology, Alkek Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    J Cell Biol 185:827-39. 2009
    ..Most importantly, the TRF1 protein-stabilizing activity of GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition. This work reveals novel aspects of TRF1 modulation by GNL3L...
  96. ncbi TRFH domain is critical for TRF1-mediated telomere stabilization
    Keiji Okamoto
    Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Japan
    Cell Struct Funct 34:71-6. 2009
    ..that these abnormal telomere structures are not caused by the inability of TRF1-deficient cells to recruit TIN2 but are due to a specific role for TRF1 at telomeres...
  97. pmc OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation
    Ma Wan
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:26725-31. 2009
    The telosome/shelterin, a six-protein complex formed by TRF1, TRF2, RAP1, TIN2, POT1, and TPP1, functions as the core of the telomere interactome, acting as the molecular platform for the assembly of higher order complexes and ..
  98. pmc POT1 association with TRF2 regulates telomere length
    Megan F Kendellen
    Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 29:5611-9. 2009
    ..Mechanistically, expression of POT1(DeltaOB) reduced the association of TRF2 with POT1, RAP1, and TIN2; however, of these proteins, only ectopic expression of POT1 suppressed the telomere elongation induced by POT1(..
  99. pmc Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells
    Silvia Canudas
    Molecular Pathogenesis Program and Department of Pathology, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 187:165-73. 2009
    ..The same phenotype is observed upon depletion of the telomeric protein TIN2. In contrast, in SA2-depleted cells telomere cohesion is normal, but centromere cohesion is prematurely lost...
  100. pmc Androgen receptor interacts with telomeric proteins in prostate cancer cells
    Sahn Ho Kim
    Vattikuti Urology Institute, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 285:10472-6. 2010
    ..We reported previously that dominant-negative mutants of one of the telomeric proteins called TIN2 cause death of androgen receptor (AR)-negative but not AR-positive prostate cancer cells, raising the question of a ..

Research Grants13

  1. Nya D Nelson; Fiscal Year: 2015
    ..Fifteen percent of patients with DC have mutations in the seventh gene, TINF2, which encodes TIN2, a central member of the telomeric binding complex shelterin...
  2. Jack D Griffith; Fiscal Year: 2015
    ..In AIM I, the core telomere binding proteins (TRF1, TRF2, Pot1, TPP1, hRap1, and Tin2) highly purified and in hand together with co-complexes of these proteins assembled in vivo will be assembled onto ..
  3. Telomeric Function in Aging Syndromes
    Jan Karlseder; Fiscal Year: 2010
    ..TRF1 interacting factors are Tin2, tankyrase 1 and 2 and Pot1, all of which have been implicated in telomere length regulation...
  4. Determinants of Telomerase-Negative Cancer Cells
    Sahn Ho Kim; Fiscal Year: 2005
    ..TRF1 is a negative regulator of telomere length. TRF2 has a protective role in telomere. Another human protein, TIN2, forms a complex with TRF1 and TRF2 and thus appears to be a crucial organizer of a complex containing TRFl-..
  5. Mechanism and Consequences of Telomere Dysfunction
    Zhou Songyang; Fiscal Year: 2012
    ..Furthermore, TPP1 forms the human telosome, along with POT1, TRF1, TRF2, RAP1, and TIN2. Our findings suggest that TPP1 controls telomere length by regulating telomere recruitment of POT1 and telomerase...
  6. Toru Nakamura; Fiscal Year: 2016
    ..cells, GT-rich telomeric repeats are bound by the six-protein "shelterin" complex (composed of TRF1, TRF2, RAP1, TIN2, TPP1 and POT1) and extended by the specialized reverse transcriptase known as telomerase...
  7. Sheila A Stewart; Fiscal Year: 2014
    ..Six proteins, TRF1, TRF2, RAP1, TIN2, TPP1, and POT1 form a core complex that is constitutively present at the telomere and required for telomere ..
  8. Structure of the Telomere Shelterin Complex
    Ming Lei; Fiscal Year: 2012
    ..3'-extension at the chromosome end, and these are bridged through protein-protein interactions involving TIN2 and TPP1. The sixth protein, RAP1, binds mostly to TRF2...
  9. Model for Targeting Tankyrase1 in Cancer Therapy
    ZHENG SHENG YE; Fiscal Year: 2005
    ..TRF1 is a telomeric DNA binding protein that negatively influences telomere length homeostasis. Tankyrase1 and TIN2 are tethered to telomeres through interacting with TRF1...
  10. BIOCHEMICAL GENETIC STUDIES OF CELL SURVIVAL PATHWAYS
    Zhou Songyang; Fiscal Year: 2005
    ..The specific aims of this proposal are to: 1. Investigate the role of Akt in hematopoietic survival using primary cells and in chimera mice. 2. Elucidate the molecular mechanisms of how Akt mediates cell survival. ..
  11. Clinical Applications of a Novel Fanconi Anemia Assay
    Akiko Shimamura; Fiscal Year: 2007
    ..abstract_text> ..
  12. Molecular cytology of human telomeres-telomere protein
    Titia de Lange; Fiscal Year: 2004
    ..Understanding how telomeres protect chromosome ends is important since telomere function has been implicated in human cancer. ..
  13. Hematopoietic Cell Survival by Protein Kinase CISK
    Zhou Songyang; Fiscal Year: 2007
    ..3. Investigate the physiological role of CISK in cell survival and development in mice, by studying how CISK affects hematopoietic cell development and survival using chimeric and knock-out mouse models. ..