thyroglobulin

Summary

Gene Symbol: thyroglobulin
Description: thyroglobulin
Alias: AITD3, TGN, thyroglobulin
Species: human

Top Publications

  1. doi Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
    Sharon J Gardiner
    Department of Medicine, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Clin Gastroenterol Hepatol 6:654-60; quiz 604. 2008
  2. doi Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio
    Sharon J Gardiner
    Department of Medicine, University of Otago, Christchurch, New Zealand
    J Gastroenterol Hepatol 26:49-54. 2011
  3. ncbi Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Oncol Rep 18:715-20. 2007
  4. pmc Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 73:736-47. 2003
  5. ncbi Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease
    J E Collins
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 88:5039-42. 2003
  6. ncbi Association of a thyroglobulin gene polymorphism with Hashimoto's thyroiditis in the Japanese population
    Yoshiyuki Ban
    Third Department of Internal Medicine, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    Clin Endocrinol (Oxf) 61:263-8. 2004
  7. ncbi Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom
    J E Collins
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Clin Endocrinol Metab 89:6336-9. 2004
  8. pmc Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism
    Mihaela Stefan
    Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 286:31168-79. 2011
  9. ncbi Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease
    Susan E Hodge
    Division of Clinical Genetic Epidemiology, New York State Psychiatric Institute, New York, New York
    Thyroid 16:351-5. 2006
  10. ncbi Association between a C/T polymorphism in exon 33 of the thyroglobulin gene is associated with relapse of Graves' hyperthyroidism after antithyroid withdrawal in Taiwanese
    Jeng Yueh Hsiao
    Department of Endocrinology and Metabolism, Kaohsiung Medical University Chung Ho Memorial Hospital, 100 Shin Chuan 1st Road, Kaohsiung 80761, Taiwan, Republic of China
    J Clin Endocrinol Metab 92:3197-201. 2007

Research Grants

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
  2. Molecular Analysis of the CCC185 Golgin
    Suzanne R Pfeffer; Fiscal Year: 2010
  3. Wolfgang Baehr; Fiscal Year: 2016
  4. Gregory S Payne; Fiscal Year: 2016
  5. DANIEL C DIMAIO; Fiscal Year: 2016
  6. Clathrin adaptor function at the trans Golgi network and endosomes
    Gregory Payne; Fiscal Year: 2007
  7. Drs2p Function in Clathrin-coated Vesicle Budding
    Todd R Graham; Fiscal Year: 2013
  8. Frances M Brodsky; Fiscal Year: 2016
  9. Sarah F Hamm-Alvarez; Fiscal Year: 2016
  10. Role of PACS proteins in polycystin-2 trafficking and ADPKD
    Gary Thomas; Fiscal Year: 2010

Detail Information

Publications496 found, 100 shown here

  1. doi Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
    Sharon J Gardiner
    Department of Medicine, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand
    Clin Gastroenterol Hepatol 6:654-60; quiz 604. 2008
    ..The purpose of this study was to determine thiopurine dose requirements in intermediate versus normal TPMT metabolism status...
  2. doi Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio
    Sharon J Gardiner
    Department of Medicine, University of Otago, Christchurch, New Zealand
    J Gastroenterol Hepatol 26:49-54. 2011
    Allopurinol potentiates azathioprine and 6-mercaptopurine (6-MP) by increasing 6-thioguanine nucleotide (6-TGN) metabolite concentrations...
  3. ncbi Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Oncol Rep 18:715-20. 2007
    ..measured the mRNA expression levels of three representative genes, telomerase reverse transcriptase (hTERT), thyroglobulin and thyroid transcription factor 1 (TTF-1) in twelve frozen tissue samples of ATC and six cell lines derived ..
  4. pmc Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Hum Genet 73:736-47. 2003
    ..The loci that continue to show evidence for linkage in the expanded data set represent serious candidate regions for gene identification...
  5. ncbi Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease
    J E Collins
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 88:5039-42. 2003
    ..Recent data, however, have shown linkage and association of chromosome 8q24 (containing the thyroglobulin gene) to AITD...
  6. ncbi Association of a thyroglobulin gene polymorphism with Hashimoto's thyroiditis in the Japanese population
    Yoshiyuki Ban
    Third Department of Internal Medicine, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    Clin Endocrinol (Oxf) 61:263-8. 2004
    ..Recent studies have demonstrated an association between a Tg polymorphisms and AITD, suggesting that Tg is the susceptibility gene on 8q24...
  7. ncbi Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom
    J E Collins
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Clin Endocrinol Metab 89:6336-9. 2004
    b>Thyroglobulin (Tg) is a major autoantigen for autoimmune thyroid disease (AITD). The Tg gene (Tg) has been mapped to chromosome 8q24, which has recently been linked in two independent studies to AITD...
  8. pmc Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism
    Mihaela Stefan
    Division of Endocrinology, Department of Medicine, Mount Sinai Medical Center, New York, New York 10029, USA
    J Biol Chem 286:31168-79. 2011
    ..Whole genome linkage scans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene...
  9. ncbi Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease
    Susan E Hodge
    Division of Clinical Genetic Epidemiology, New York State Psychiatric Institute, New York, New York
    Thyroid 16:351-5. 2006
    Graves' disease (GD) is influenced by two major susceptibility loci, HLA-DR3 and thyroglobulin (Tg). Recently we have shown that specific HLA-DR and Tg gene sequences predispose to Graves' disease...
  10. ncbi Association between a C/T polymorphism in exon 33 of the thyroglobulin gene is associated with relapse of Graves' hyperthyroidism after antithyroid withdrawal in Taiwanese
    Jeng Yueh Hsiao
    Department of Endocrinology and Metabolism, Kaohsiung Medical University Chung Ho Memorial Hospital, 100 Shin Chuan 1st Road, Kaohsiung 80761, Taiwan, Republic of China
    J Clin Endocrinol Metab 92:3197-201. 2007
    Graves' disease (GD) is an autoimmune disorder with genetic predisposition. The thyroglobulin (Tg) is a major autoantigen for GD. The human Tg gene polymorphism has specific features that make it important in GD.
  11. ncbi Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families
    F Molina
    CNRS UMR 9921, Faculte de Pharmacie, Montpellier, France
    Eur J Biochem 240:125-33. 1996
    The amino acid sequence of human thyroglobulin is known to enclose cysteine-rich repetitive regions...
  12. pmc Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells
    Monica Dentice
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Mol Cell Biol 25:10171-82. 2005
    ..This process reduced the expression of several thyroid-specific genes, including pendrin and thyroglobulin. Similarly, down-regulation of TTF-1 by RNA interference reduced the expression of both genes, whose promoters ..
  13. ncbi Three distinct steps in transport of vesicular stomatitis virus glycoprotein from the ER to the cell surface in vivo with differential sensitivities to GTP gamma S
    R Pepperkok
    Department of Cell Biology, Sciences III, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Cell Sci 111:1877-88. 1998
    ..Finally, transport of ts-O45-G from the trans-Golgi network (TGN) to the cell surface is inhibited only by high concentrations of GTP gamma S (500 microM)...
  14. pmc 100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties
    D H Wong
    Department of Pharmacy, School of Pharmacy, University of California San Francisco 94143 0446
    J Cell Biol 117:1171-9. 1992
    ..beta-COP was redistributed to the cytoplasm within 15 s, gamma-adaptin and clathrin in the trans-Golgi network (TGN) dispersed within 30 s, but the alpha-adaptin and clathrin present on coated pits and vesicles derived from the ..
  15. ncbi Sulfation of the N-linked oligosaccharides of influenza virus hemagglutinin: temporal relationships and localization of sulfotransferases
    M J Spiro
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Glycobiology 10:1235-42. 2000
    ..state and have reached the medial/trans Golgi and the trans Golgi network (TGN), with the former carrying out most of the sulfation activity...
  16. pmc Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin
    W Schafer
    Institut fur Virologie, Philipps Universitat Marburg, Germany
    EMBO J 14:2424-35. 1995
    ..Furin was found predominantly in the trans-Golgi network (TGN), but also in clathrin-coated vesicles dispatched from the TGN, on the plasma membrane as an integral membrane ..
  17. ncbi Calcium homeostasis in trigeminal ganglion cell bodies
    Tony D Gover
    The Neuroscience Program, University of Maryland, School of Medicine, Baltimore, MD 21201 1559, United States
    Cell Calcium 41:389-96. 2007
    ..processes contribute to electrically-evoked Ca2+ transients in TGNs, we probed Ca2+ regulatory mechanisms in TGN cell bodies from the ophthalmic division with a panel of pharmacological reagents...
  18. pmc Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, Fukushima 960 1295, Japan
    J Cell Sci 123:460-71. 2010
    ..clathrin adaptor Drosophila GGA (dGGA), a homolog of mammalian GGA proteins, localizes to the trans-Golgi network (TGN) and is capable of recruiting clathrin from the cytosol onto TGN membranes...
  19. pmc Synthetic genetic interactions with temperature-sensitive clathrin in Saccharomyces cerevisiae. Roles for synaptojanin-like Inp53p and dynamin-related Vps1p in clathrin-dependent protein sorting at the trans-Golgi network
    E S Bensen
    Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 154:83-97. 2000
    ..sorting of the vacuolar protein carboxypeptidase Y as measures of protein sorting at the yeast trans-Golgi network (TGN) compartment...
  20. doi Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis
    Thi Mai Hoang Nguyen
    Universite de Lyon, Département de Pharmacie Clinique, de Pharmacocinétique et d Evaluation du Médicament, Lyon, France
    Ther Drug Monit 32:433-7. 2010
    ..6-Thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine nucleotides (6-MeMPN) concentrations and TPMT activity were determined by high-..
  21. pmc Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly
    Viviane Poupon
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 105:168-73. 2008
    ..carriers for endocytic cargo and mediate important intracellular trafficking events at the trans-Golgi network (TGN) and endosomes...
  22. ncbi Intracellular vesicular trafficking of tyrosinase gene family protein in eu- and pheomelanosome biogenesis
    K Jimbow
    Department of Dermatology, School of Medicine, Sapporo Medical University, Japan
    Pigment Cell Res 13:110-7. 2000
    ..maturation, which reflect the transport of structural and enzymatic proteins from Golgi (trans-Golgi network: TGN) to the melanosomal compartment and their organization therein...
  23. pmc African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the plasma membrane
    Christopher L Netherton
    Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 80:11385-92. 2006
    ..African swine fever virus (ASFV) disrupts the trans-Golgi network (TGN) by altering the localization of TGN46, an organelle marker for the distal secretory pathway...
  24. ncbi Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking
    O Varlamov
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 114:311-22. 2001
    Carboxypeptidase D (CPD) is a transmembrane protein that processes proteins in the trans-Golgi network (TGN). A 20-residue region within the cytoplasmic tail of CPD binds protein phosphatase 2A (PP2A)...
  25. ncbi The Tg rasH2 mouse in cancer hazard identification
    Daniel Morton
    Pharmacia Corporation, Skokie, IL 60077, USA
    Toxicol Pathol 30:139-46. 2002
    ..The Tg rasH2 mouse, officially designated CB6F1-TgN (RasH2), contains multiple copies of the human c-Ha-ras oncogene and promoter within its genome...
  26. ncbi Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol
    D Drecktrah
    Section of Biochemistry, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 111:951-65. 1998
    Previous studies have shown that the Golgi stack and the trans-Golgi network (TGN) may play a role in capturing escaped resident endoplasmic reticulum (ER) proteins, and directing their retrograde transport back to that organelle...
  27. ncbi Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells
    Y Peng Loh
    Section on Cellular Neurobiology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    J Mol Neurosci 22:63-71. 2004
    ..precursors synthesized at the rough endoplasmic reticulum are transported and sorted at the trans-Golgi network (TGN) to the granules of the regulated secretory pathway (RSP) of neuroendocrine cells...
  28. ncbi 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial
    Max Reinshagen
    Department of Medicine I, Klinikum Braunschweig, Braunschweig, Germany
    Clin Chem 53:1306-14. 2007
    A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2.5 mg/kg/day AZA.
  29. ncbi The retromer complex and clathrin define an early endosomal retrograde exit site
    Vincent Popoff
    Laboratoire Trafic et Signalisation, UMR144 Curie CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Sci 120:2022-31. 2007
    ..epsinR, and the retromer complex in retrograde sorting from early/recycling endosomes to the trans Golgi network (TGN). However, it has remained unclear whether these protein machineries function on the same or parallel pathways...
  30. pmc P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes
    Ke Liu
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235 1634, USA
    Mol Biol Cell 19:3526-35. 2008
    ..is a resident type 4 P-type ATPase (P4-ATPase) and potential phospholipid translocase of the trans-Golgi network (TGN) where it has been implicated in clathrin function...
  31. ncbi The functional relationship between the Cdc50p-Drs2p putative aminophospholipid translocase and the Arf GAP Gcs1p in vesicle formation in the retrieval pathway from yeast early endosomes to the TGN
    Hiroshi Sakane
    Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 0815, Japan
    Cell Struct Funct 31:87-108. 2006
    ..in conjunction with the Arf1 signaling pathway in the formation of clathrin-coated vesicles (CCVs) from the TGN. Herein, we searched for Arf regulator genes whose mutations were synthetically lethal with cdc50Delta, and ..
  32. pmc Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype
    Joelle M J Romac
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 298:G518-24. 2010
    ..We have shown that targeted transgenic expression of the rat Psti1 gene to acinar cells in mice [TgN(Psti1)] protects mice against caerulein-induced pancreatitis...
  33. pmc Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin
    L J Page
    Department of Clinical Biochemistry and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, England
    J Cell Biol 146:993-1004. 1999
    The AP-1 adaptor complex is associated with the TGN, where it links selected membrane proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated vesicles...
  34. ncbi Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing
    Alexander Teml
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Clin Pharmacokinet 46:187-208. 2007
    ..Although the therapeutic response appears to be related to 6-thioguanine nucleotide (6-TGN) concentrations above a threshold of 230-260 pmol per 8 x 10(8) red blood cells, at present therapeutic drug ..
  35. pmc The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting
    Gonzalo A Mardones
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:3486-501. 2007
    The sorting of acid hydrolase precursors at the trans-Golgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capture of the hydrolase-MPR complexes into clathrin-coated vesicles or transport ..
  36. doi Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes
    Vincent Popoff
    Institut Curie Centre de Recherche, Traffic, Signaling and Delivery Laboratory, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Traffic 10:1868-80. 2009
    ..and retromer have key functions for retrograde trafficking between early endosomes and the trans-Golgi network (TGN). Previous studies on Shiga toxin suggested that these two coat complexes operate in a sequential manner...
  37. ncbi Assembly, target-signaling and intracellular transport of tyrosinase gene family proteins in the initial stage of melanosome biogenesis
    K Jimbow
    Department of Dermatology, School of Medicine, Sapporo Medical University, Japan
    Pigment Cell Res 13:222-9. 2000
    ..These melanosomal glycoproteins are then accumulated in the trans Golgi network (TGN) and transported to the melanosomal compartment...
  38. ncbi 7B2 is a specific intracellular binding protein of the prohormone convertase PC2
    S Benjannet
    J A DeSève Laboratories of Molecular, Clinical Research Institute of Montreal, Quebec, Canada
    J Neurochem 64:2303-11. 1995
    ..the slow exit of pro-PC2 from the endoplasmic reticulum (ER) and its concentration within the trans-Golgi network (TGN)...
  39. pmc Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway
    G Liu
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Cell Biol 139:1719-33. 1997
    Furin catalyzes the proteolytic maturation of many proproteins within the trans-Golgi network (TGN)/endosomal system...
  40. ncbi Clathrin and adaptors
    J Hirst
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Biochim Biophys Acta 1404:173-93. 1998
    ..The AP-1 adaptor complex is associated with clathrin-coated vesicles budding from the TGN, while the AP-2 adaptor complex is associated with clathrin-coated vesicles budding from the plasma membrane...
  41. ncbi Analytic aspects of monitoring therapy with thiopurine medications
    Victor W Armstrong
    Department of Clinical Chemistry, George August University, D 37075 Goettingen, Germany
    Ther Drug Monit 26:220-6. 2004
    ..They are converted in vivo to the active 6-thioguanine nucleotides (6-TGN)...
  42. ncbi Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases
    Jörg Schedel
    Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, D 93042 Regensburg, Germany
    Ann N Y Acad Sci 1069:477-91. 2006
    ..potential correlations between the concentration of the azathioprine metabolite 6-thioguanine nucleotide (6-TGN) in erythrocytes (RBC) and inflammatory disease activity as well as hematological AE were investigated...
  43. pmc The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment
    Jeffrey M Melancon
    Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, USA
    Virol J 4:120. 2007
    ..In this manuscript, we examined the effect of UL20 mutations on the coordinate transport and Trans Golgi Network (TGN) localization of UL20p and gK, virus-induced cell fusion and infectious virus production...
  44. doi A 6-thioguanine nucleotide threshold level of 400 pmol/8 x 10(8) erythrocytes predicts azathioprine refractoriness in patients with inflammatory bowel disease and normal TPMT activity
    Xavier Roblin
    Department of Gastroenterology, CHU Grenoble, Grenoble, France
    Am J Gastroenterol 103:3115-22. 2008
    A therapeutic level of 6-thioguanine nucleotides (6-TGN) has been reported in inflammatory bowel disease (IBD) patients under azathioprine (AZA)...
  45. ncbi The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal
    M J Petris
    The Murdoch Institute, Royal Children s Hospital, Parkville 3052, Australia
    Hum Mol Genet 8:2107-15. 1999
    ..MNK is normally localized pre- dominantly in the trans -Golgi network (TGN); however, when cells are exposed to excessive copper it is rapidly relocalized to the plasma membrane where it ..
  46. ncbi Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit
    M Teuchert
    Institut für Virologie der Philipps Universität Marburg, Robert Koch Strasse 17, 35037 Marburg, Germany
    J Biol Chem 274:36781-9. 1999
    ..intracellular localization of the eukaryotic subtilisin-like endoprotease furin is the trans-Golgi network (TGN), but a small fraction is also found on the cell surface...
  47. ncbi Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Pediatrics, The University Hospital and The University of Copenhagen, Denmark
    J Clin Oncol 21:1332-9. 2003
    ..We explored whether dose adjustment of MP and MTX by erythrocyte (E) levels of TGN and MTX (including polyglutamates) could improve outcome in childhood acute lymphoblastic leukemia (ALL).
  48. ncbi Pharmacological monitoring of azathioprine therapy
    L O Reuther
    Dept of Clinical Pharmacology, Gentofte University Hospital, Hellerup, Denmark
    Scand J Gastroenterol 38:972-7. 2003
    ..between clinical remission and a concentration in erythrocytes of the metabolites 6-thioguanine nucleotides (E-6-TGN) above 230 pmol/8 x 10(8) RBC...
  49. ncbi A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group)
    B A Bell
    Department of Pediatric Hematology Oncology, Medical College of Georgia Children s Medical Center, Georgia Cancer Coalition Distinguished Cancer Clinician, Augusta 30912 3730, USA
    Pediatr Blood Cancer 43:105-9. 2004
    ..oxidase (XO), mercaptopurine is converted into two major intracellular metabolites, thioguanine nucleotide (TGN) and methylated mercaptopurine metabolites (including methylated thioinosine nucleotides), which are cytotoxic in ..
  50. pmc The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network
    Zi Zhao Lieu
    The Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Mol Biol Cell 18:4979-91. 2007
    Retrograde transport pathways from early/recycling endosomes to the trans-Golgi network (TGN) are poorly defined. We have investigated the role of TGN golgins in retrograde trafficking...
  51. doi BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells
    Sheung Kwan Lam
    Department of Biology and Molecular Biotechnology Program, Centre for Cell and Developmental Biology, State China Key Laboratory for Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Plant J 60:865-81. 2009
    ..At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome (EE) equivalent in plant cells, to form visible aggregates in transgenic tobacco BY-2 cells...
  52. pmc Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
    Alberto M Díaz Añel
    Center for Molecular Genetics, University of California at San Diego, San Diego, CA, USA
    Biochem J 406:157-65. 2007
    The requirement of DAG (diacylglycerol) to recruit PKD (protein kinase D) to the TGN (trans-Golgi network) for the targeting of transport carriers to the cell surface, has led us to a search for new components involved in this regulatory ..
  53. pmc Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes
    F Javier Pérez-Victoria
    Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 19:2350-62. 2008
    ..acid hydrolases to lysosomes relies on transmembrane, mannose 6-phosphate receptors (MPRs) that cycle between the TGN and endosomes...
  54. doi Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes
    Jana Zimmermann
    Biochemie III, Fakultat fur Chemie, Universitätstrasse 25, Universitat Bielefeld, 33615 Bielefeld, Germany
    Biochem J 431:123-34. 2010
    ..N-terminal homology] domain protein Ent5p serve as partially redundant adaptors in vesicle budding from the TGN (trans-Golgi network) in Saccharomyces cerevisiae...
  55. pmc A novel Rab9 effector required for endosome-to-TGN transport
    E Diaz
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    J Cell Biol 138:283-90. 1997
    ..These data are consistent with a model in which p40 and Rab9 act together to drive the process of transport vesicle docking...
  56. pmc Two syntaxin homologues in the TGN/endosomal system of yeast
    J C Holthuis
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 17:113-26. 1998
    ..are located in separable compartments which correspond to a putative early endosome and the yeast equivalent of the TGN, respectively...
  57. ncbi Endocytic routes to the Golgi apparatus
    M Pavelka
    Institute of Histology and Embryology, University of Innsbruck, Austria
    Histochem Cell Biol 109:555-70. 1998
    ..Considerable amounts of internalised molecules were taken up into the trans Golgi network (TGN) and into Golgi subcompartments in all three cell types as well as in secretory granules of the pancreatic beta ..
  58. ncbi A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins
    L Kjer-Nielsen
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia 3181
    Curr Biol 9:385-8. 1999
    ..Previously, we have identified a carboxy-terminal domain of the trans-Golgi-network (TGN) protein p230 that is responsible for Golgi localisation [1]...
  59. pmc AtVPS45 complex formation at the trans-Golgi network
    D C Bassham
    Michigan State University Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824 1312, USA
    Mol Biol Cell 11:2251-65. 2000
    ..a member of this family from Arabidopsis thaliana that we now demonstrate to be present on the trans-Golgi network (TGN), where it colocalizes with the vacuolar cargo receptor AtELP...
  60. ncbi Early events of secretory granule formation in the rat parotid acinar cell under the influence of isoproterenol. An ultrastructural and lectin cytochemical study
    F D'Amico
    Centro di Microscopia Elettronica di Medicina, University of Catania, Italy
    Eur J Histochem 45:169-75. 2001
    ..Specimens were embedded in the Lowicryl K4M resin. The trans-Golgi network (TGN) derived secretory granules, which we refer to as immature secretory granules, were found to be intermediate ..
  61. ncbi Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furin
    A M Band
    Department of Biosciences, Division of Biochemistry, Viikki Biocenter, University of Helsinki, Finland
    FEBS Lett 505:118-24. 2001
    ..SFV) glycoprotein precursor p62 is processed to the E2 and E3 during the transport from the trans-Golgi network (TGN) to the cell surface...
  62. ncbi The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners
    Vera Kreykenbohm
    Zentrum Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, Universitat Gottingen, Germany
    Eur J Cell Biol 81:273-80. 2002
    ..Both proteins had a distinct but overlapping localization. vtila was found predominantly on the Golgi and the TGN, vtilb mostly on tubules and vesicles in the TGN area and on endosomes...
  63. ncbi The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
    Yunbo Gan
    Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    Nat Cell Biol 4:605-9. 2002
    ..Sorting occurs post-synthetically, in the trans Golgi network (TGN) or after internalization from the cell surface in recycling endosomes, and is mediated by apical and basolateral ..
  64. pmc PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal
    Jing Wang
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Biol Cell 18:2646-55. 2007
    Phosphatidylinositol 4 phosphate (PI4P) is highly enriched in the trans-Golgi network (TGN)...
  65. ncbi The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network
    Miriam V Bujny
    The Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Sci 120:2010-21. 2007
    ..of the cation-independent mannose 6-phosphate receptor (CI-MPR) from early endosomes to the trans Golgi network (TGN)...
  66. ncbi Reaching and grasping phenotypes in the mouse (Mus musculus): a characterization of inbred strains and mutant lines
    V Tucci
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK
    Neuroscience 147:573-82. 2007
    ..early phenotypes for the characterization of motor neurone (Tg[SOD1-G93A](dl)1Gur mice) and neurodegenerative (TgN(HD82Gln)81Dbo transgenic mice) disease models in addition to specific motor deficits associated with aging (C3H/HeH ..
  67. pmc Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
    Yanling Zhang
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Proc Natl Acad Sci U S A 104:17518-23. 2007
    ..Selective membrane trafficking pathways, especially endosome-to-TGN retrograde trafficking, are defective...
  68. ncbi The role of xanthine oxidase in thiopurine metabolism: a case report
    Dennis R Wong
    Department of Clinical Pharmacy, Orbis Medical Center, Maasland Hospital, Sittard, The Netherlands
    Ther Drug Monit 29:845-8. 2007
    ..Despite good patient compliance, the active metabolites of AZA, 6-thioguanine nucleotides (6-TGN), and 6-methylmercaptopurine ribonucleotides (6-MMPR) could not be detected in the erythrocytes (RBC)...
  69. doi The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation
    Ha T T Phan
    Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Endocrinol 158:77-83. 2008
    This retrospective study describes the role of serum thyroglobulin (Tg) in relation to tumor characteristics in the prediction of persistent/recurrent disease in patients with differentiated thyroid cancer (DTC) with negative Tg at the ..
  70. pmc Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules
    Elias T Spiliotis
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 180:295-303. 2008
    ..of apical and basolateral plasma membrane domains depend on protein sorting from the trans-Golgi network (TGN) and vesicle delivery to the plasma membrane...
  71. pmc The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit
    Lars Demmel
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, D 01307, Germany
    Mol Biol Cell 19:1991-2002. 2008
    ..key regulator of membrane transport required for the formation of transport carriers from the trans-Golgi network (TGN). The molecular mechanisms of PI(4)P signaling in this process are still poorly understood...
  72. pmc The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport
    Shigeo Hara
    Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Mol Biol Cell 19:3823-35. 2008
    ..nexins (SNX) 1, 2, 5, and 6, which make up a multimeric protein complex mediating endosome-to-trans-Golgi-network (TGN) retrograde transport of the cation-independent mannose 6-phosphate receptor (CI-MPR)...
  73. pmc Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways
    Maribel Donoso
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile and the Millenium Institute for Fundamental and Applied Biology, Santiago, Chile
    Mol Biol Cell 20:481-97. 2009
    ..Here we show that during biosynthetic trafficking LRP1 uses AP1B adaptor complex to move from a post-TGN recycling endosome (RE) to the basolateral membrane...
  74. pmc Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31
    A G Rodriguez-Gabin
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Exp Cell Res 315:2215-30. 2009
    ..a protein that we originally cloned from a rat oligodendrocyte cDNA library, localizes in the trans-Golgi network (TGN) and endosomes. However, its function has not yet been established...
  75. doi Protein kinase D-dependent trafficking of the large Herpes simplex virus type 1 capsids from the TGN to plasma membrane
    Gaudeline Rémillard-Labrosse
    Department of Pathology and Cell Biology, University of Montreal, Quebec, Canada
    Traffic 10:1074-83. 2009
    The biosynthetic pathway carries cargos from the endoplasmic reticulum (ER) to the trans Golgi network (TGN) via a typical passage through the Golgi...
  76. pmc The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network
    Thomas Wassmer
    The Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Dev Cell 17:110-22. 2009
    Early endosome-to-trans-Golgi network (TGN) transport is organized by the retromer complex. Consisting of cargo-selective and membrane-bound subcomplexes, retromer coordinates sorting with membrane deformation and carrier formation...
  77. pmc Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network
    Shane Minogue
    Department of Inflammation, Division of Medicine, University College London, Centre for Molecular Cell Biology, London, United Kingdom
    J Lipid Res 51:2314-24. 2010
    ..revealed that the reduction in the mobile fraction of PI4KIIalpha correlated with a loss of trans-Golgi network (TGN) membrane connectivity...
  78. doi Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease
    Melissa L Haines
    Department of Medicine, Eastern Health, Monash University, Victoria, Australia
    Inflamm Bowel Dis 17:1301-7. 2011
    Circulating concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methyl mercaptopurine (6-MMP) are associated with thiopurine efficacy and may predict toxicity...
  79. doi Short-term cultivation of in situ prevascularized tissue constructs accelerates inosculation of their preformed microvascular networks after implantation into the host tissue
    Matthias W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Tissue Eng Part A 17:841-53. 2011
    ..Poly(ester-urethane) scaffolds were implanted into FVB/N-TgN (Tie2/green fluorescent protein [GFP]) 287 Sato mice to generate prevascularized tissue constructs with GFP-..
  80. doi Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs
    Shirin Meher Pocha
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Biol 21:1111-7. 2011
    ..for the retrograde transport of numerous transmembrane proteins from endosomes to the trans-Golgi network (TGN) and is conserved between plants, fungi, and animals [2]...
  81. doi Visualization of TGN-endosome trafficking in mammalian and Drosophila cells
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Methods Enzymol 504:255-71. 2012
    Mannose 6-phosphate receptors (MPRs) are known to be shuttled between the trans-Golgi network (TGN) and endosomes, thereby several lysosomal hydrolases are delivered through the endocytic pathway into lysosomes...
  82. pmc A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales
    S K Service
    Center for Neurobehavioral Genetics, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e116. 2012
    ..Item response theory methodology may be a way to incorporate data from cohorts assessed with multiple personality instruments, and might be a method by which a large sample of a more refined phenotype could be acquired...
  83. doi hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins
    Maaike S Pols
    Department of Cell Biology, University Medical Centre Utrecht, AZU Room H02 313, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Nat Commun 4:1361. 2013
    ....
  84. pmc Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection
    Patricia M Day
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:3862-70. 2013
    ..to virion and cellular proteins, we found that the viral pseudogenome and L2 travel to the trans-Golgi network (TGN) following exit from the LE, while L1 is retained...
  85. doi An in vivo expression system for the identification of cargo proteins of vacuolar sorting receptors in Arabidopsis culture cells
    Jinbo Shen
    School of Life Sciences, Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Plant J 75:1003-17. 2013
    ..proteins that in plant cells are thought to recognize cargo proteins at the late Golgi or trans-Golgi network (TGN) for vacuolar transport via the pre-vacuolar compartment (PVC)...
  86. doi Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants
    Magdalena J Lorenowicz
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Cell Signal 26:19-31. 2014
    ..To maintain efficient Wnt secretion, Wls is recycled back to the trans-Golgi network (TGN) through a retromer dependent endosome to TGN retrieval pathway...
  87. pmc Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum
    Bruno Di Jeso
    From the Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita del Salento, 73100 Lecce, Italy
    J Biol Chem 289:11488-96. 2014
    Newly synthesized thyroglobulin (Tg), the thyroid prohormone, forms detectable high molecular weight mixed disulfide adducts: until now, only Tg "adduct B" was identified as primarily engaging the endoplasmic reticulum oxidoreductases ..
  88. pmc Characterization of the sterol and phosphatidylinositol 4-phosphate binding properties of Golgi-associated OSBP-related protein 9 (ORP9)
    Xinwei Liu
    Departments of Pediatrics, Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 9:e108368. 2014
    ..ORP9L and PI-4P did not co-localize in the trans-Golgi/TGN of HeLa cells, and siRNA silencing of ORP9L expression did not affect PI-4P distribution in the Golgi apparatus...
  89. doi Threonine 576 residue of amyloid-β precursor protein regulates its trafficking and processing
    Yoon Sun Chun
    Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Biochem Biophys Res Commun 467:955-60. 2015
    ..Newly synthesized APP is transported from endoplasmic reticulum to the plasma membrane via trans-Golgi network (TGN) after post-translational modification including N- and O-glycosylation...
  90. pmc Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion
    Tim Eiseler
    From the Department of Internal Medicine I, Ulm University, Albert Einstein Allee 23, D 89081 Ulm, Germany and
    J Biol Chem 291:462-77. 2016
    Vesicle formation and fission are tightly regulated at the trans-Golgi network (TGN) during constitutive secretion...
  91. pmc The Adaptor Complex AP-4 Regulates Vacuolar Protein Sorting at the trans-Golgi Network by Interacting with VACUOLAR SORTING RECEPTOR1
    Kentaro Fuji
    Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan K F, M S, Y S, T K, Y K, H T, I H N, T S andPlant Global Educational Project, Nara Institute of Science and Technology, Ikoma 630 0192, Japan Y F
    Plant Physiol 170:211-9. 2016
    ..AP4M bound to the tyrosine-based motif of VSR1. AP4M localized at the trans-Golgi network (TGN) subdomain that is distinct from the AP-1-localized TGN subdomain...
  92. pmc Plant endosomal NHX antiporters: Activity and function
    Quan Sheng Qiu
    a MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu, China
    Plant Signal Behav 11:e1147643. 2016
    ..They are localized in the Golgi, trans-Golgi network (TGN), and prevacuolear compartment (PVC)...
  93. pmc Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network
    Alvaro H Crevenna
    Physical Chemistry, Department of Chemistry Center for Nanoscience, Nanosystems Initiative Munich and Center for Integrated Protein Science Munich, Ludwig Maximilians University Munich, 81377 Munich, Germany
    J Cell Biol 213:305-14. 2016
    Sorting and export of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well understood...
  94. doi Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study
    Polychronis Pavlidis
    Surrey and Sussex Healthcare NHS Trust, East Surrey Hospital, Redhill, United Kingdom Department of Gastroenterology, King s College Hospital NHS Foundation Trust, King s Health Partners East Surrey Clinical Commissioning Group Assistant Chair and School of Pharmacy and Mater Research Institute, The University of Queensland, Brisbane, Australia
    Inflamm Bowel Dis 22:1639-46. 2016
    ..while a layer of complexity has been added by the trend toward treatment directed by red cell thioguanine nucleotide (TGN) profiling. We report on the clinical efficacy and safety of LDAA use in IBD undirected by metabolite profiling.
  95. pmc Trigeminal neuralgia caused by brain arteriovenous malformations: A case report and literature review
    Yongjie Yuan
    Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, P R China
    Exp Ther Med 12:69-80. 2016
    Few cases of trigeminal neuralgia (TGN) induced by brain arteriovenous malformations (bAVMs) have previously been reported...
  96. pmc A Distinct Pathway for Polar Exocytosis in Plant Cell Wall Formation
    Hao Wang
    School of Life Sciences, Centre for Cell and Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China H W, X Z, X W, A H Y L, L J College of Life Sciences, South China Agricultural University, Guangzhou 510642, China H W Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China T Z, S D, M M T L Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China S D andCUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China L J
    Plant Physiol 172:1003-1018. 2016
    ..sorting and trafficking to the plasma membrane (PM) is generally believed to occur via the trans-Golgi network (TGN)...
  97. ncbi Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures
    Shilpi Yadav
    a Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Platelets . 2016
    ..we found that each and every resting human platelet was positive for cis, trans, and trans Golgi network (TGN) proteins. However, in each case, the proteins were found in small puncta scattered about the platelet...
  98. ncbi Differential use of two AP-3-mediated pathways by lysosomal membrane proteins
    Gudrun Ihrke
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Wellcome Trust MRC Building, Cambridge CB2 2XY, UK
    Traffic 5:946-62. 2004
    ..It is unclear whether AP-3-containing vesicles form at the trans-Golgi network (TGN) or early endosomes...
  99. pmc Qa-SNAREs localized to the trans-Golgi network regulate multiple transport pathways and extracellular disease resistance in plants
    Tomohiro Uemura
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 109:1784-9. 2012
    ..cells, a membrane-trafficking system connects the post-Golgi organelles, such as the trans-Golgi network (TGN), endosomes, vacuoles, and the plasma membrane...
  100. pmc Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number
    Brian Storrie
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Traffic 13:727-44. 2012
    ..suggest that Golgi function in cargo transport is preferentially inhibited at the trans-Golgi/trans-Golgi network (TGN)...
  101. ncbi TGN38 cycles via the basolateral membrane of polarized Caco-2 cells
    B J Reaves
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, UK
    Mol Membr Biol 15:133-9. 1998
    ..heavily glycosylated, type I integral membrane protein which is predominantly localized to the trans Golgi network (TGN), but which constitutively traffics between the TGN and the cell surface...

Research Grants67

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Molecular Analysis of the CCC185 Golgin
    Suzanne R Pfeffer; Fiscal Year: 2010
    ..this application is to investigate the molecular function of a protein named GCC185, a 185K, trans Golgi network (TGN)-localized protein of the GRIP domain family...
  3. Wolfgang Baehr; Fiscal Year: 2016
    ..Vesicles emerge from the trans-Golgi network (TGN) and transport to the base of the cilium where fusion with the cell membrane occurs...
  4. Gregory S Payne; Fiscal Year: 2016
    ..sorting plasma membrane proteins into the endocytic pathway and sorting proteins between the trans Golgi network (TGN) and endosomes...
  5. DANIEL C DIMAIO; Fiscal Year: 2016
    ..In addition, incoming, partially disassembled HPV16 capsids localize to the trans-Golgi network (TGN) in a retromer-dependent fashion, and components of the retromer are in a physical complex with HPV capsid proteins ..
  6. Clathrin adaptor function at the trans Golgi network and endosomes
    Gregory Payne; Fiscal Year: 2007
    A major sorting station in the secretory pathway is the trans Golgi network (TGN), where proteins are directed to the plasma membrane, endosomes, and lysosomes...
  7. Drs2p Function in Clathrin-coated Vesicle Budding
    Todd R Graham; Fiscal Year: 2013
    ..Drs2 localizes to the trans-Golgi network (TGN) and is required to bud AP-1/clathrin-coated vesicles from this organelle by a mechanism that is independent of ..
  8. Frances M Brodsky; Fiscal Year: 2016
    ..from the plasma membrane (PM), endosomal traffic, and organelle biogenesis from the trans-Golgi network (TGN)...
  9. Sarah F Hamm-Alvarez; Fiscal Year: 2016
    ..packaging of materials destined for apically-targeted secretory vesicles (SV) occurs in the trans-Golgi network (TGN)...
  10. Role of PACS proteins in polycystin-2 trafficking and ADPKD
    Gary Thomas; Fiscal Year: 2010
    ..Also, we showed that PACS-1 is an AP-1 connector that localizes polycystin-2 to the trans-Golgi network (TGN)...
  11. Tomas Kirchhausen; Fiscal Year: 2016
    ..Clathrin coated vesicles are also important for traffic between endosomes and the trans-Golgi network (TGN)...
  12. Irina Kaverina; Fiscal Year: 2016
    ..of Golgi-derived microtubules, and golgin GCC185 serves as an anchor for CLASPs at the trans-Golgi network (TGN) at the Golgi periphery...
  13. CELL MUTANTS DEFECTIVE IN CHOLESTEROL ESTER FORMATION
    Ta Yuan Chang; Fiscal Year: 2012
    ..Two Specific Aims are proposed: Specific Aim 1: To test the hypothesis that the trans-Golgi network (TGN) serves as a key organelle for transporting low-density lipoprotein (LDL)-derived cholesterol from the endosomes to ..
  14. Suzanne R Pfeffer; Fiscal Year: 2016
    ..recognizes the MPRs in late endosomes (TIP47), a pathway- specific SNARE complex for fusion of MPR-vesicles at the TGN, and two proteins that function in vesicle tethering at the Golgi (GCC185 and RhoBTB3)...
  15. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    ..Final envelopment of VZV occurs in the trans-Golgi network (TGN)...
  16. Myelin Biogenesis: Vesicle Transport in Oligodendrocytes
    JORGE LAROCCA; Fiscal Year: 2006
    ..rRab22b, a novel Rab protein that is present in oligodendrocytes, regulates transport from the trans-Golgi network (TGN) to the endosomes...
  17. VZV Receptors & Infective Mechanisms
    Anne Gershon; Fiscal Year: 2001
    ..MPRs); this pathway is followed because VZV is enveloped by MPR-containing cisternae of the trans-Golgi network (TGN)...
  18. MARK A MC NIVEN; Fiscal Year: 2016
    ..on the vesicle-based machinery utilized by the hepatocyte at the plasma membrane (PM) and trans-Golgi network (TGN) to sort and traffic distinct receptors and cargo proteins...
  19. ENRIQUE J RODRIGUEZ-BOULAN; Fiscal Year: 2016
    ..We will test the hypothesis that TGN Golgins, elongated coil-coil molecules that bind membranes via rabs, mediate highly dynamic physical interactions ..
  20. Martina Buck; Fiscal Year: 2014
    ..Trans Golgi network (TGN) sorting and exocytosis of the viral particle, through site-specific phosphorylations of <1 a subunit of the ..
  21. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2004
    ..that AZA, an inactive pro-drug, undergoes a series of enzymatic reactions leading to 6-thioguanine nucleotides (6- TGN), considered the active but, myelotoxic, metabolites...
  22. Multi-site Trial of Azathioprine Dosing in Crohn Disease
    Stephen Hanauer; Fiscal Year: 2003
    ..that AZA, an inactive pro-drug, undergoes a series of enzymatic reactions leading to 6-thioguanine nucleotides (6- TGN), considered the active but, myelotoxic, metabolites...
  23. ER-to-cell surface transport and signal regulation of GPCRs
    Guangyu Wu; Fiscal Year: 2013
    ..GGAs associate with alpha2B-AR and are required for alpha2B-AR transport from the trans-Golgi network (TGN) to the plasma membrane...
  24. Robert H Edwards; Fiscal Year: 2016
    ..In the trans-Golgi network (TGN), proteins destined for LDCVs aggregate to form a dense core, suggesting that lumenal or possibly membrane ..
  25. DUSANKA DANIELLE DERETIC; Fiscal Year: 2016
    ..and the Arf/Rab11 effector FIP3, and determine its mode of interaction with rhodopsin at the trans-Golgi network (TGN), which is essential for ciliary targeting; 2...
  26. Tohru Fukai; Fiscal Year: 2016
    ..copper exporter ATP7A whose function is mediated through copper-dependent translocation from trans-Golgi network (TGN) as well as copper chaperon, antioxidant-1 (Atox1) which obtains copper from CTR1 and transfer it to ATP7A...
  27. TUG-mediated GLUT4 glucose transporter trafficking and regulation by post-transla
    JONATHAN PHILIP BELMAN; Fiscal Year: 2012
    ..hypothesizes TUG to function in an intracellular anchoring mechanism for GLUT4 involving the trans-Golgi network (TGN) protein GCC185, a known mediator of vesicle trafficking...
  28. ANNE MUESCH; Fiscal Year: 2015
    ..Whereas columnar epithelia target their plasma membrane (PM) proteins predominantly from the trans Golgi network (TGN) to the AP domain, hepatocytes target both AP and BL PM proteins from the TGN to the BL surface, from where AP ..
  29. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen L Collins; Fiscal Year: 2013
    ..prevents phosphorylation of the MHC-I cytoplasmic tail and disrupts MHC-I transport from the trans-Golgi network (TGN) to the cell surface. MHC-I is then targeted for degradation in lysosomes...
  30. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..Using a novel pH-sensitive GFP technology, we have recently reported that trans-Golgi network (TGN) is hyperacidified in CF respiratory epithelial cells...
  31. Role of HCMV Glycoprotein in Viral Biogenesis
    Gary Thomas; Fiscal Year: 2005
    ..suggest that following transport of viral capsids to the cytoplasm, they are enveloped at the trans-Golgi Network (TGN) and associated endosomal compartments by membranes studded with envelope glycoproteins...
  32. GOLGI TARGETING AND RETENTION OF YEAST KEX2 PROTEASE
    Robert Fuller; Fiscal Year: 2009
    Steady-state localization of transmembrane proteins of the trans Golgi network (TGN) is achieved by dynamic recycling between TGN and endosomal compartments. These transport pathways localize processing enzymes (e.g...
  33. ENZYMOLOGY OF GOLGI STACK FORMATION
    Vivek Malhotra; Fiscal Year: 2007
    ..We are specifically interested in the fission of transport carriers of the trans Golgi network (TGN) to the cell surface pathway...
  34. CONTROL OF CONNEXIN TRANSPORT AND ASSEMBLY
    Michael Koval; Fiscal Year: 2004
    ..In contrast, CX46 remains a monomer and is restricted to the trans Golgi network (TGN). The goal of this proposal is to understand how CX43 and CX46 are differentially regulated by these cells...
  35. MAL proteolipids in apical protein delivery in epithelia
    Pamela Tuma; Fiscal Year: 2004
    ..Proteins using the direct pathway are delivered directly form the trans-Golgi network (TGN) to the apical surface whereas proteins using the indirect pathway take a more circuitous route...
  36. SYNTHESIS AND DISTRIBUTION OF PROTEINS IN MEMBRANES
    David Sabatini; Fiscal Year: 2004
    ..with the nature of the carrier vesicles that mediate the transport of proteins from the trans-Golgi network (TGN) to the cell surface of epithelial cells...
  37. Plasma Membrane Trafficking in Polarized Hepatocytes
    Ann Hubbard; Fiscal Year: 2005
    We will study the molecular basis of trans-Golgi-network (TGN) to plasma membrane (PM) trafficking in polarized hepatic cells...
  38. STRUCTURE/FUNCTION OF THE TRANS GOLGI NETWORK
    Kathryn Howell; Fiscal Year: 2002
    ..that there are unique sets of molecules and structures involved in moving proteins and lipids out of the hepatocyte TGN. We have identified six molecules functioning in the constitutive pathway...
  39. MAL2 regulation of hepatic protein trafficking: mechanisms and binding partners
    Pamela L Tuma; Fiscal Year: 2012
    ..Unlike simple epithelial cells that directly target newly synthesized proteins from the TGN to the apical PM, hepatocytes mainly use an indirect pathway where apical proteins are first delivered to the ..
  40. CYTOSKELETAL REGULATION OF VESICLE TRANSPORT IN LIVER
    MARK MC NIVEN; Fiscal Year: 2006
    ..and Epsl5 comprise a conserved molecular machinery that functions differentially at both the plasma membrane and TGN to mediate vesicle formation in the hepatocyte during endocytosis and secretion...
  41. Regulation of BetaAPP Traffciking and Neuronal Functions
    Dongming Cai; Fiscal Year: 2006
    ..Previous studies suggest that the distribution of betaAPP between the trans-Golgi network (TGN) and cell surface has a direct influence upon the generation of Aa This phenomenon makes delineation of the ..
  42. VESICLE TRAFFICKING AND PANCREATIC ACINAR CELL SECRETION
    MARK MC NIVEN; Fiscal Year: 2004
    ..that support the agonist-induced formation and transport of zymogen granules from the trans-Golgi network (TGN) to the apical membrane for subsequent enzyme release...
  43. Role of PACS-1 in HIV-1 Immunoevasion
    Gary Thomas; Fiscal Year: 2007
    ..We have found that this pathway begins when HIV-1 Nef pirates PACS-1 to target to the TGN, enabling Nef to recruit a Src family kinase (SFK); subsequently, this complex binds to and activates PI3K...
  44. Yasuko Rikihisa; Fiscal Year: 2016
    ..Our working hypothesis is that TGN-SNARE machinery is involved in transport of NPC1 vesicles containing LDL-CHOL to Anaplasma inclusions, and ..
  45. Robert C Piper; Fiscal Year: 2016
    ..We believe that such understanding will open new avenues for therapeutic interventions that manipulate the process of lysosomal degradation to target a range of biological processes. ..
  46. Weiming Yuan; Fiscal Year: 2016
    ..In particular, gB targets and relocates CD1d molecules to the TGN, while US3 blocks CD1d recycling and facilitates more gB-mediated CD1d relocalization to the TGN...
  47. Functional Subdomain Organization of the Recycling Endosome
    David R Sheff; Fiscal Year: 2010
    ..We have also observed that these subdomains, as well as retrograde traffic to the TGN are dependent upon the function of PI 3-Kinase...
  48. Modification of a Tegument Protein during the Assembly of HSV-1
    Richard J Courtney; Fiscal Year: 2010
    ..within the cytoplasm in association with membranes and is incorporated into the virus during its envelopment at the TGN. If our hypothesis proves to be correct, this will represent one of the first examples as to how the dynamic ..
  49. Richard A Kahn; Fiscal Year: 2016
    ..acts in cells as an ArfGAP that can attenuate Arf signaling at the Golgi and impact membrane traffic also at the TGN, where it has effector properties...
  50. Genetics and Functions of HSV Membrane Fusion Proteins
    KONSTANTIN KOUSOULAS; Fiscal Year: 2009
    ..We have shown that HSV-1 gK and UL20p are co-dependent for cell-surface expression and TGN localization, and that they physically interact...
  51. FIBROUS SCAFFOLD-INDUCED SPHEROIDS MIMICKING TME
    Sandhya Boyapalle; Fiscal Year: 2013
    ..Transgenex Nanobiotech Inc. (TGN) in collaboration with the University of South Florida has developed a nanofiber scaffold (FSSTM) that enables ..
  52. HIV Nef Ubiquitination and Its Functions
    Yong Jiu Jin; Fiscal Year: 2009
    ..pathological activity is the downregulation of cell surface CD4 and rerouting MHC-1 intracellular trafficking from TGN to the endosomes, the Nef ubiquitination could be the signals required for Nef/target complexes to enter endosomal/..
  53. Axonal arborization of sensory neurons in zebrafish
    YUCHIN PAN; Fiscal Year: 2009
    ..During development, a trigeminal sensory neuron (TGN) extends two types of projections: a peripheral axon and a central axon...
  54. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Gerardo Fernandez; Fiscal Year: 2005
    The trans-Golgi network (TGN) and endosomes are major sites for sorting and trafficking of a variety of biosynthetic and endocytic proteins, including factors that are involved in cholesterol homeostasis, virus infection, and cell ..
  55. How FcRn Prolongs IgG Lifespan
    CLARK ANDERSON; Fiscal Year: 2005
    ..antibodies localize FcRn not only to a cytoplasmic vesicular compartment but as well to the trans-Golgi network (TGN), which we propose, serves as a reservoir for trafficking FcRn...
  56. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  58. PRESENILIN DOMAINS AND RECONSTITUTION OF CATALYSIS
    Samuel Gandy; Fiscal Year: 2007
    ..This investigation will permit the identification of the minimal functional unit for gamma-secretase activity and potentially support the notion that PS1 is indeed the catalytic component of the gamma-secretase complex. ..
  59. TRANSMITTER NEUROANATOMY IN ALZHEIMERS DISEASE
    Samuel Gandy; Fiscal Year: 2002
    ....
  60. HCMV US2 & US11 Inhibition of MHC Class II Presentation
    David Johnson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Herpes Simplex Virus Transmission Across Cell Junctions
    David Johnson; Fiscal Year: 2007
    ..The cytoplasmic domain of gE/gl affects sorting of the glycoprotein to trans-Golgi network (TGN) of cells and plays an important role in virus envelopment into cytosolic membranes...
  62. Hantavirus Vaccines Based On Nonreplicating Adenoviruses
    David Johnson; Fiscal Year: 2005
    ..This will be a prelude to challenge experiments in which vaccinated hamsters will be challenged with Andes virus that causes a lethal pulmonary disease similar to that in humans. ..
  63. The role of NFkB in glia-neuron crosstalk in glaucoma
    Valery Shestopalov; Fiscal Year: 2008
    ..The methodology that will be tested here and the results that will be obtained in this feasibility study can be utilized to search for and test new potential therapeutic targets for glaucoma. [unreadable] [unreadable] [unreadable]..
  64. Yaron Tomer; Fiscal Year: 2016
    ..This could have a major impact on public health, as it may facilitate the development of mechanism-based treatments in autoimmunity, such as CD40 blockade. ..
  65. HETEROGENEITY OF CAVEOLAE IN INTESTINAL EPITHELIA
    Kamran Badizadegan; Fiscal Year: 2004
    ..Furthermore, by using signal transduction by cholera toxin (CT) in intestinal epithelia as a classical model of DIG-mediated function, these studies extend our understanding of the pathogenesis of enterotoxicrenic secretory diarrhea. ..