Genomes and Genes
Gene Symbol: thrombomodulin
Alias: AHUS6, BDCA3, CD141, THPH12, THRM, thrombomodulin, CD141 antigen, fetomodulin
Publications182 found, 100 shown here
- Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surfaceC T Esmon
Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
FASEB J 9:946-55. 1995..The pathway is initiated when thrombin binds to the endothelial cell thrombin binding protein, thrombomodulin. The complex exhibits dramatically altered macromolecular specificity...
- Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up studyK Auro
Department of Molecular Medicine, KTL, Helsinki, Finland
Arterioscler Thromb Vasc Biol 26:942-7. 2006b>Thrombomodulin is an anticoagulant expressed during endothelial activation and damage...
- Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune responseStephanie T Yerkovich
Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 123:209-216.e4. 2009..It has been suggested that intrinsic properties of allergens can directly stimulate T(H)2 polarizing functions of DCs, but little is known of the underlying mechanisms...
- An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platformJyh Chiang E Wang
Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol Methods 341:106-16. 2009..with analysis of activation status and endocytic ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform...
- Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigensSarah L Jongbloed
Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
J Exp Med 207:1247-60. 2010..We report the first detailed functional analysis of the human CD141+ DC subset...
- Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cellsLionel Franz Poulin
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
J Exp Med 207:1261-71. 2010..Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function...
- Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effectMarie Christine Bouton
Unité INSERM U698, CHU Xavier Bichat, Paris, France
Circ Res 100:1174-81. 2007The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation...
- RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatmentChiu Hung Yeh
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Mol Biol Cell 19:3812-22. 2008..b>Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects...
- A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in menC J Doggen
Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
Thromb Haemost 80:743-8. 1998b>Thrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis...
- Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in KoreansHyun Young Park
Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan
Hypertens Res 25:389-94. 2002b>Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo...
- Haemostatic gene polymorphisms in young indian asian subjects with acute myocardial infarctionNaresh Ranjith
Department of Medicine, Coronary Care Unit, RK Khan Hospital and Chemical Pathology, University of Natal, Durban, South Africa
Med Sci Monit 9:CR417-21. 2003....
- Silencing of the thrombomodulin gene in human malignant melanomaJunichi Furuta
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
Melanoma Res 15:15-20. 2005The loss of thrombomodulin (TM) expression is associated with tumour growth, infiltration and lymph node metastasis in human tumours...
- Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase IIMonique David-Dufilho
Department of Signalisation Cellulaire et Atherosclerose Precoce, Universite Paris 6 CNRS, Paris 75014, France
J Biol Chem 280:35999-6006. 2005Endothelial membrane-bound thrombomodulin is a high affinity receptor for thrombin to inhibit coagulation...
- Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese populationShoko Sugiyama
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
Thromb Res 119:35-43. 2007b>Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese.
- Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cellsMasahiro Iwata
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 377:642-7. 2008b>Thrombomodulin (TM) is an endothelial cell surface anticoagulant glycoprotein that performs antimetastatic, angiogenic, adhesive, and anti-inflammatory functions in various tissues. It is also expressed in epidermal keratinocytes...
- Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsAnnabell Bachem
Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
J Exp Med 207:1273-81. 2010..into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets...
- Thrombomodulin is present in human plasma and urineH Ishii
J Clin Invest 76:2178-81. 1985b>Thrombomodulin is an endothelial cell membrane protein that is a cofactor required for the rapid activation of plasma protein C...
- A common thrombomodulin amino acid dimorphism is associated with myocardial infarctionL Norlund
Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
Thromb Haemost 77:248-51. 1997..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C ..
- Thrombomodulin Ala455Val polymorphism and risk of coronary heart diseaseK K Wu
Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
Circulation 103:1386-9. 2001b>Thrombomodulin (TM) is expressed on the endothelial surface and plays an important role in vasoprotection...
- Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarctionYi Heng Li
Department of Internal Medicine and Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Thromb Haemost 87:86-91. 2002b>Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C...
- Characterization of thrombomodulin gene mutations of the 5'-regulatory regionFumie Nakazawa
Atherosclerosis 164:385-7. 2002
- Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM proHidemi Ishii
Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
Blood 101:4765-74. 2003The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (..
- Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombinLikui Yang
Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
J Biol Chem 278:37465-70. 2003b>Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor (PCI) by 2-3 orders of magnitude...
- Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients <or =50 years of ageTing Hsing Chao
Department of Internal Medicine, Tainan, Taiwan
Am J Cardiol 93:204-7. 2004Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI)...
- A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in menC J Konstantoulas
British Heart Foundation Laboratories, Department of Medicine, Center for Cardiovascular Genetics, Royal Free and University College London Medical School, Rayne Building, London WC1E 6JF, UK
Atherosclerosis 177:97-104. 2004..study of myocardial infarction (MI), we identified risk associated with the combination of two variants in the thrombomodulin (TM) gene (-1208-1209TTdelTT and A455V) and an interaction with increased body mass index (BMI)...
- Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa BRichard H Sohn
Division of Cardiology, Johns Hopkins School of Medicine, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21287, USA
Blood 105:3910-7. 2005..Endothelial cell expression of thrombomodulin (TM), a key component of the anticoagulant protein C pathway, is potently inhibited by inflammatory cytokines...
- Association study of the thrombomodulin -33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han populationJiangong Zhao
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road 167, Beijing 100037, China
Int J Cardiol 100:383-8. 2005b>Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C...
- C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cellsBicheng Nan
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
Surgery 138:212-22. 2005..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells.
- JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoterYuanyuan Rong
The Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, China
FEBS Lett 584:852-8. 2010b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases...
- Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transitionYuan Chung Kao
Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Mol Cell Biol 30:4767-85. 2010The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
- Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanismLinda Nocchi
Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
J Biol Chem 286:19478-88. 2011Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process...
- Thrombomodulin and its role in inflammationEdward M Conway
Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
Semin Immunopathol 34:107-25. 2012The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
- Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitroLing Yuh Shyu
Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
Thromb Res 129:43-9. 2012..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)...
- Effects of shear stress on the gene expressions of endothelial nitric oxide synthase, endothelin-1, and thrombomodulin in human retinal microvascular endothelial cellsAkihiro Ishibazawa
Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
Invest Ophthalmol Vis Sci 52:8496-504. 2011..Physiological shear stress is higher in the retinal microcirculatory network than in other organs. The effects of laminar shear stress on gene expression in human retinal microvascular endothelial cells (HRMECs) was investigated...
- Association of thrombomodulin gene polymorphisms and plasma thrombomodulin levels with acute myocardial infarction in north Indian patientsRupinder Dogra
1Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Clin Appl Thromb Hemost 19:637-43. 2013This is the first study from north India that investigated the association of thrombomodulin (TM) polymorphisms with acute myocardial infarction (AMI) in 350 patients (≤ 40 years, n = 184 and ≥ 60 years, n = 166) and 350 matched-..
- Role of thrombomodulin gene in Indian population with coronary artery diseaseSwarup A Shah
Research Laboratories, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
Biomarkers 17:610-7. 2012b>Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker.
- Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infectionMeera R Gupta
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
Respir Res 14:71. 2013..In this study, we examined the effect of RSV on the functional response of primary mDC subsets (BDCA-1(+) and BDCA-3(+)) isolated from peripheral blood...
- Thrombomodulin expression regulates tumorigenesis in bladder cancerChun Te Wu
Chang Gung University, College of Medicine, Taoyuan, Taiwan
BMC Cancer 14:375. 2014The identification of potential tumor markers will help improve therapeutic planning and patient management. Thrombomodulin (TM) is a sensitive urothelial marker...
- Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and functionGabriella Kunz
Department of Haematology, Imperial College School of Medicine, London, United Kingdom
Blood 99:3646-53. 2002Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored...
- Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammationMarlies Van de Wouwer
The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
Arterioscler Thromb Vasc Biol 24:1374-83. 2004..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a ..
- Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriageM Kaare
Folkhalsan Institute of Genetics, University of Helsinki, Finland
Hum Reprod 22:864-8. 2007..Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice...
- Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE StudyN Aleksic
Division of Hematology, University of Texas Medical School, Houston, TX 77030, USA
J Thromb Haemost 1:88-94. 2003Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex...
- Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleuraMarkku Miettinen
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Am J Surg Pathol 27:150-8. 2003Several immunohistochemical markers, among them calretinin, thrombomodulin (CD141), keratin 5, and mesothelin, have been documented or suggested as useful markers for positive identification of mesothelioma and to differentiate it from ..
- Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulinRashmi Sood
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
Blood 112:585-91. 2008Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from trophoblast cells of the mouse placenta causes a fatal arrest of placental morphogenesis...
- The thrombomodulin-protein C system is essential for the maintenance of pregnancyBerend Isermann
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
Nat Med 9:331-7. 2003Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect in the placenta...
- Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breastN B Teo
Pathology Department, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
Br J Cancer 86:905-11. 2002..were determined using morphometry and a panel of anti-endothelial antibodies (von Willebrand factor, CD31, CD141 and CD34) and related to the presence of invasive carcinoma and other histological features...
- Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell sourceDorthe Schmidt
Clinic for Cardiovascular Surgery and Department of Surgical Research, University and University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
Circulation 116:I64-70. 2007..A novel concept providing prenatally tissue engineered human autologous heart valves based on routinely obtained fetal amniotic fluid progenitors as single cell source is introduced...
- Peritubular capillary loss is ameliorated by ramipril or valsartan treatmentBin Zhang
Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
Microcirculation 15:337-48. 2008..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection...
- Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineeringDorthe Schmidt
Clinic for Cardiovascular Surgery, Department of Surgical Research, University, University Hospital, Zurich, Switzerland
J Heart Valve Dis 17:446-55; discussion 455. 2008..In order to expand the versatility of these cells also for adult application, cryopreserved AFDC were investigated as a potential life-long available cell source for heart valve tissue engineering...
- Three DNA methylation epigenotypes in human colorectal cancerKoichi Yagi
Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Clin Cancer Res 16:21-33. 2010..Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more comprehensively...
- Surface antigens of human mesangial cells: impact of growth surface or IL-1alphaG Sengoelge
Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wien, Austria
Tissue Antigens 60:383-95. 2002..58, 90, 106, 146, 147, 166; growth factor receptors: CD105, 140b; apoptosis related: CD95; hemostatis related: CD141, 142; miscellaneous: CD44, 109, 138, 151, 157, 165, and 11 nonclustered antigens) reacted with mesangial cells...
- Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivoDawn K Coletta
Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
Am J Physiol Endocrinol Metab 294:E910-7. 2008..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation...
- Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defenseY D Dean
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, GB
Eur J Immunol 31:1370-81. 2001Phagocytic complement C1q receptor (C1qRp) and thrombomodulin (TM, CD141), are two key members of a novel family of lectin receptors involved in cell-cell interactions and innate immune host defense...
- Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophagesGeert R Verheyen
Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
Toxicol In Vitro 18:377-91. 2004..Our data indicate the multitude of biological processes potentially influenced by DEP...
- VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lungA M Healy
The Pulmonary Center, Boston University School of Medicine, Boston Massachusetts 02118, USA
Dev Dyn 219:341-52. 2000..Platelet endothelial cell adhesion molecule-1 (PECAM/CD31) and thrombomodulin (TM/CD141) immunolocalization demonstrate that vascular development occurs in lung cultures...
- Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomesL Iannuzzi
National Research Council CNR, IABBAM, Laboratory of Animal Cytogenetics, Via Argine 1085, 80147 Naples Ponticelli, Italy
Cytogenet Cell Genet 93:124-6. 2001..Indirect comparisons between physical maps achieved on bovid chromosomes and those reported on HSA10, HSA11 and HSA20 were performed...
- Phenotypic differences between red pulp capillary and sinusoidal endothelia help localizing the open splenic circulation in humansBirte Steiniger
Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 8, 35032, Marburg, Germany
Histochem Cell Biol 128:391-8. 2007..Double staining for CD34 and CD141 (thrombomodulin) revealed that capillary endothelia in the cords of the splenic red pulp and at the surface of follicles were ..
- FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitisKristina Lundberg
Department of Immunotechnology, Lund University, Lund, Sweden
Hum Immunol 71:931-3. 2010..In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses...
- Cytogenetic alignment of the bovine chromosome 13 genome map by fluorescence in-situ hybridization of human chromosome 10 and 20 comparative markersD S Gallagher
Department of Animal Science, Texas A and M University, College Station 77843, USA
Chromosome Res 7:115-9. 1999..These FISH results anchor the BTA13 genome map from bands 14-23, and confirm the presence of a conserved HSA10 homologous synteny group on BTA13 centromeric to a HSA20 homologous segment...
- Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumorsJennifer Brady
Brain Inflammation and Immunity Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
J Neuropathol Exp Neurol 63:1274-83. 2004..Its protein domain architecture is homologous to that of CD93 and thrombomodulin (CD141), suggesting a similar function in mediating cell-cell interactions...
- [Chiparray-based identification of gene expression in HUVECs treated with low frequency electric fields]D Ulrich
Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, Universitatsklinikum Aachen, Germany
Handchir Mikrochir Plast Chir 38:149-55. 2006..In this study, we report on IN VITRO studies performed to characterize gene expression profiles using a DNA-microarray in HUVECs (human umbilical vein endothelial cells) exposed to low frequency electrical current...
- Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cellsMaria Tsoumakidou
Lung Pathology Unit, London SW3 6LY, UK
Respir Med 103:935-8. 2009..We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells...
- Assessment of physiological amplitude, duration, and magnitude of ECG T-wave alternansLaura Burattini
Department of Biomedical, Electronics, and Telecommunication Engineering, Polytechnic University of Marche, 60131 Ancona, Italy
Ann Noninvasive Electrocardiol 14:366-74. 2009....
- Isolation of human blood DC subtypesAndrew J Kassianos
Mater Medical Research Institute, South Brisbane, QLD, Australia
Methods Mol Biol 595:45-54. 2010..CD11c(+) myeloid DC, which can be further subdivided into three subsets based on differential expression of CD1c, CD141 and CD16...
- Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factorsSanja Stankovic
Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade, Serbia
Crit Rev Clin Lab Sci 47:72-123. 2010..The data assembled could be very useful for further meta-analysis and for future clinical applications...
- Screening of the HLDA9 panel on peripheral blood dendritic cell populationsYitian Ding
Mater Medical Research Institute, Aubigny Place, South Brisbane, Queensland, Australia
Immunol Lett 134:161-6. 2011..The CD11c(+) myeloid DC can be divided into populations by CD1c, CD16 and CD141 expression...
- Mouse models of thrombosis: thrombomodulinHartmut Weiler
Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Department of Physiology, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
Thromb Haemost 92:467-77. 2004This review describes animal models of TM-deficiency that cause thrombosis in mice. Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway by facilitating the activation of protein C by thrombin...
- Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell linesMasayoshi Imura
Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
Cancer Lett 241:213-20. 2006..It was shown that aberrant methylation and demethylation were frequently observed in ovarian cancer cell lines, and these data will provide a basis for further epigenetic analysis in ovarian cancers...
- Correlation between thrombomodulin and severe preeclampsia: a summaryViroj Wiwanitkit
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Clin Appl Thromb Hemost 14:99-101. 2008b>Thrombomodulin is a critical cofactor in the initiation of the protein C anticoagulant pathway...
- IL-32-dependent effects of IL-1beta on endothelial cell functionsClaudia A Nold-Petry
Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 106:3883-8. 2009..In contrast, the anti-inflammatory/anti-coagulant CD141/thrombomodulin increased markedly when IL-32 was silenced...
- Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndromeTara K Maga
Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hum Mutat 31:E1445-60. 2010..5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD). Since aHUS is rare, mutation rate data in large patient cohorts are scarce...
- High levels of protein C are determined by PROCR haplotype 3M C Pintao
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
J Thromb Haemost 9:969-76. 2011..Recently, we identified a locus on chromosome 20 determining high PC levels in a large Dutch pedigree with unexplained thrombophilia. Candidate genes in the LOD-1 support interval included FOXA2, THBD and PROCR...
- Evaluation of various endothelial biomarkers in ankylosing spondylitisAli Taylan
Department of Rheumatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
Clin Rheumatol 31:23-8. 2012..von Willebrand factor (vWF), soluble thrombomodulin (sTM), and urotensin (UT-II) were found to be significantly higher in the sera of the patients compared to the ..
- Small supernumerary marker chromosomes derived from chromosomes 6 and 20 in a woman with recurrent spontaneous abortionsNarjes Guediche
Universite Paris Sud, Service d Histologie Embryologie et Cytogénétique, APHP, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141 Clamart, France
Eur J Med Genet 55:737-42. 2012..This report underpins the necessity of array CGH for characterizing precisely sSMC and helping in genotype-phenotype correlations. Furthermore, a literature review on sSMC is included...
- Prevalence of thrombosis-related DNA polymorphisms in a healthy Greek populationChristos Yapijakis
Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece
In Vivo 26:1095-101. 2012..F12) C46T, plasma carboxypeptidase B2 (CPB2) C1040T, platelet glycoprotein Ib α polypeptide (GP1BA) VNTR, thrombomodulin (THBD) -A33G and protein Z (PROZ) - A13G have not...
- Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-βChun I Yu
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Immunity 38:818-30. 2013..Here, we analyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) DCs in determining the type of CD8(+) T cell immunity generated to live-attenuated influenza virus (LAIV) ..
- Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkersCheng Jeng Tai
Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China
Tumour Biol 35:47-54. 2014b>Thrombomodulin (TM) has been shown to regulate many physiological and pathological processes, including inflammation, thrombosis, and tumor progression...
- Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsetsMasaaki Toda
Department of Immunology, Mie University Graduate School of Medicine, Tsu Shi, Mie Ken, Japan
PLoS ONE 8:e72392. 2013Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface...
- Preliminary assessment of differential expression of candidate genes associated with atherosclerosisJoan Blin
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia UPM
Genes Genet Syst 88:199-209. 2013..insulin receptor substrate 1 (IRS1), lipoprotein lipase (LPL), methylenetetrahydrofolate reductase (MTHFR), thrombomodulin (THBD), lecithin-cholesterol acyltransferase (LCAT), matrix metallopeptidase 9 (MMP9), low density lipoprotein ..
- Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cellsTakashi Maejima
Research Center for Advanced Science and Technology, The University of Tokyo, Meguro ku, Tokyo, Japan Tokyo New Drug Research Laboratories, Kowa Company Ltd, Higashimurayama, Tokyo, Japan
PLoS ONE 9:e96005. 2014..revealed that the atheroprotective genes induced with pitavastatin, such as nitric oxide synthase 3 (NOS3) and thrombomodulin (THBD), were suppressed by KLF4 knockdown...
- Heterogeneity of stromal cells in the human splenic white pulp. Fibroblastic reticulum cells, follicular dendritic cells and a third superficial stromal cell typeBirte S Steiniger
Institute of Anatomy and Cell Biology, University of Marburg, Marburg, Germany
Immunology 143:462-77. 2014..partially overlapping shells of stromal cells exhibiting CD90 (Thy-1), MAdCAM-1, CD105 (endoglin), CD141 (thrombomodulin) and smooth muscle α-actin (SMA) with expression of CD90 characterizing the broadest shell and SMA the ..
- Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individualsJussi Ryynänen
School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
Mol Nutr Food Res 58:2036-45. 2014..Vitamin D₃, its biologically most active metabolite 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and the vitamin D receptor (VDR) are important for adipose tissue biology...
- Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expressionTsung Lin Cheng
1 Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
J Invest Dermatol 135:1668-75. 2015Keratinocyte-expressed thrombomodulin (TM) and the released soluble TM (sTM) have been demonstrated to promote wound healing...
- Circulating precursors of human CD1c+ and CD141+ dendritic cellsGaelle Breton
Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065
J Exp Med 212:401-13. 2015..to earlier progenitors with greater developmental potential, the hpre-CDC is restricted to producing CD1c(+) and CD141(+) Clec9a(+) cDCs...
- Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infectionSteven Kho
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Infect Immun 83:3224-32. 2015..household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141(+), and CD1c(+) myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 ..
- Identification of Genetic Aberrations in Thrombomodulin Gene in Patients With Recurrent Venous ThromboembolismAbrar Ahmad
1 Department of Clinical Sciences, Center for Primary Health Care Research, Skane University Hospital, Lund University, Lund, Sweden
Clin Appl Thromb Hemost . 2017b>Thrombomodulin (THBD) serves as a cofactor for thrombin-mediated activation of anticoagulant protein C pathway. Genetic aberrations in THBD have been studied in arterial and venous thrombosis...
- The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genesYunlei Cao
Fudan University, 130 Dong an Road, Shanghai 200032, China NPFPC Laboratory of Contraception and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China
Gene 530:248-52. 2013..study were to investigate the effects of polymorphisms in hemostasis-related genes antithrombin (SERPINC1), thrombomodulin (THBD), tissue factor pathway inhibitor (TFPI), factor V, factor II and annexin A5 (ANXA5), involved in ..
- Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney diseaseAndrew J Kassianos
Conjoint Kidney Research Laboratory, Pathology Queensland, Queensland Institute of Medical Research, Level 9, Bancroft Centre, Herston 4006, Queensland, Australia
Am J Physiol Renal Physiol 305:F1391-401. 2013..We detected significantly greater numbers of total DCs as well as CD141(hi) and CD1c(+) myeloid DC (mDCs) subsets in diseased biopsies with interstitial fibrosis than diseased biopsies ..
- Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis riskSilvia Navarro
Unidad de Bioquimica, Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
Arterioscler Thromb Vasc Biol 33:1435-40. 2013..1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels...
- Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementationCarsten Carlberg
School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
PLoS ONE 8:e71042. 2013..The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for ..
- Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)D R Maglott
American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852 1776, USA
Mamm Genome 7:400-1. 1996
- The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?B Steiniger
Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 6, D 35033 Marburg, Germany
Am J Pathol 159:501-12. 2001..and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141)...
- Genetic risk for restenosis after coronary balloon angioplastyHideki Horibe
Department of Cardiology, Kosei Hospital, Anjo, Japan
Atherosclerosis 174:181-7. 2004..two polymorphisms (242C --> T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C --> T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G --> A in the paraoxonase 1 (PON1) gene and 2445G --> A ..
- Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein CLikui Yang
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
Proc Natl Acad Sci U S A 103:879-84. 2006..The binding of Ca(2+) to the 70-80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM...
- Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosisBerend Isermann
Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
Nat Med 13:1349-58. 2007..Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy...
- Thrombomodulin gene polymorphisms in brain infarction and mortality after strokeJean Marc Olivot
INSERM U698 and Denis Diderot University Paris VII, Dept of Neurology and Stroke Center, Bichat University Hospital, Paris, France
J Neurol 255:514-9. 2008b>Thrombomodulin is expressed at the surface of endothelial cells and controls thrombin generation and thrombin-induced platelets and vascular cell activation...
- Impaired binding of thrombin to thrombomodulin is associated with risk of deep vein thrombosisEtsuji Suehisa
Laboratory for Clinical Investigation, Osaka University Hospital, Suita City, Osaka, Japan
Thromb Res 123:85-92. 2008The complex of thrombin and thrombomodulin (TM) activates protein C, and impaired binding of thrombin to TM may be a risk factor for thrombosis...
- Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cellsI Chung Lo
Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
Cardiovasc Res 81:771-9. 2009b>Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear...
- [Effect of C5a on expression of thrombomodulin in endothelial cells in vitro]Wei Fang
Guangzhou Medical College, Guangzhou 510010, Guangdong, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:168-71. 2009To investigate the effect of C5a on the expression of thrombomodulin (TM) in human umbilical vein endothelial cells (HUVECs).
- Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly ICHenning Lauterbach
Department of Research Immunology, Bavarian Nordic GmbH, 82152 Martinsried, Germany
J Exp Med 207:2703-17. 2010..Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of ..
- Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombinLaurent O Mosnier
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 286:502-10. 2011b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation...
- NUTRITION ACADEMIC AWARDMichael Miller; Fiscal Year: 2004..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..
- INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLSLloyd Mayer; Fiscal Year: 2007In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
- ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHYCHARLENE HAFER MACKO; Fiscal Year: 2002..We also found that thrombomodulin (TM), an endothelial membrane receptor that deactivates thrombin and accelerates activated protein C formation ..
- MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMESMichael Miller; Fiscal Year: 2003..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
- Genetic Reg. of Hematopoietic Stem Cell MobilizationHartmut Geiger; Fiscal Year: 2007..g. to muscle tissue, or to other hematopoietic niches. ..
- Direct Cellular Effects of Blood Coagulation ProteasesLAURENT MOSNIER; Fiscal Year: 2007..I propose: 1) To characterize the formation of endothelial cell membrane receptor complexes between thrombomodulin, [unreadable] endothelial protein C receptor and protease activated receptor-1 required for APC generation and ..
- Individual Propensity to Venous ThrombosisJohn Heit; Fiscal Year: 2009..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..