thrombomodulin

Summary

Gene Symbol: thrombomodulin
Description: thrombomodulin
Alias: AHUS6, BDCA3, CD141, THPH12, THRM, thrombomodulin, CD141 antigen, fetomodulin
Species: human

Top Publications

  1. ncbi Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
    C T Esmon
    Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    FASEB J 9:946-55. 1995
  2. ncbi Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study
    K Auro
    Department of Molecular Medicine, KTL, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 26:942-7. 2006
  3. doi Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response
    Stephanie T Yerkovich
    Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 123:209-216.e4. 2009
  4. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
  5. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
  6. pmc Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    Lionel Franz Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    J Exp Med 207:1261-71. 2010
  7. ncbi Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect
    Marie Christine Bouton
    Unité INSERM U698, CHU Xavier Bichat, Paris, France
    Circ Res 100:1174-81. 2007
  8. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
  9. ncbi A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men
    C J Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 80:743-8. 1998
  10. ncbi Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans
    Hyun Young Park
    Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan
    Hypertens Res 25:389-94. 2002

Research Grants

  1. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004
  2. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Lloyd Mayer; Fiscal Year: 2007
  3. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
  4. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
  5. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
  6. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT MOSNIER; Fiscal Year: 2007
  7. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009

Detail Information

Publications182 found, 100 shown here

  1. ncbi Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
    C T Esmon
    Oklahoma Medical Research Foundation, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    FASEB J 9:946-55. 1995
    ..The pathway is initiated when thrombin binds to the endothelial cell thrombin binding protein, thrombomodulin. The complex exhibits dramatically altered macromolecular specificity...
  2. ncbi Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study
    K Auro
    Department of Molecular Medicine, KTL, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 26:942-7. 2006
    b>Thrombomodulin is an anticoagulant expressed during endothelial activation and damage...
  3. doi Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response
    Stephanie T Yerkovich
    Telethon Institute for Child Health Research, Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 123:209-216.e4. 2009
    ..It has been suggested that intrinsic properties of allergens can directly stimulate T(H)2 polarizing functions of DCs, but little is known of the underlying mechanisms...
  4. pmc An 11-color flow cytometric assay for identifying, phenotyping, and assessing endocytic ability of peripheral blood dendritic cell subsets in a single platform
    Jyh Chiang E Wang
    Human Immunology Center, David H Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol Methods 341:106-16. 2009
    ..with analysis of activation status and endocytic ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform...
  5. pmc Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
    Sarah L Jongbloed
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 207:1247-60. 2010
    ..We report the first detailed functional analysis of the human CD141+ DC subset...
  6. pmc Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    Lionel Franz Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    J Exp Med 207:1261-71. 2010
    ..Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function...
  7. ncbi Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect
    Marie Christine Bouton
    Unité INSERM U698, CHU Xavier Bichat, Paris, France
    Circ Res 100:1174-81. 2007
    The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation...
  8. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..b>Thrombomodulin (TM) is a critical factor to activate protein C in mediating the anticoagulation and anti-inflammation effects...
  9. ncbi A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men
    C J Doggen
    Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    Thromb Haemost 80:743-8. 1998
    b>Thrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis...
  10. ncbi Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans
    Hyun Young Park
    Department of Laboratory Medicine, Shimane Medical University, Izumo, Japan
    Hypertens Res 25:389-94. 2002
    b>Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo...
  11. ncbi Haemostatic gene polymorphisms in young indian asian subjects with acute myocardial infarction
    Naresh Ranjith
    Department of Medicine, Coronary Care Unit, RK Khan Hospital and Chemical Pathology, University of Natal, Durban, South Africa
    Med Sci Monit 9:CR417-21. 2003
    ....
  12. ncbi Silencing of the thrombomodulin gene in human malignant melanoma
    Junichi Furuta
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Melanoma Res 15:15-20. 2005
    The loss of thrombomodulin (TM) expression is associated with tumour growth, infiltration and lymph node metastasis in human tumours...
  13. ncbi Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II
    Monique David-Dufilho
    Department of Signalisation Cellulaire et Atherosclerose Precoce, Universite Paris 6 CNRS, Paris 75014, France
    J Biol Chem 280:35999-6006. 2005
    Endothelial membrane-bound thrombomodulin is a high affinity receptor for thrombin to inhibit coagulation...
  14. ncbi Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population
    Shoko Sugiyama
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Thromb Res 119:35-43. 2007
    b>Thrombomodulin (TM) is an essential cofactor in protein C activation by thrombin. Here, we evaluated the contribution of genetic variations in the TM gene to soluble TM (sTM) level and deep vein thrombosis (DVT) in Japanese.
  15. doi Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cells
    Masahiro Iwata
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 377:642-7. 2008
    b>Thrombomodulin (TM) is an endothelial cell surface anticoagulant glycoprotein that performs antimetastatic, angiogenic, adhesive, and anti-inflammatory functions in various tissues. It is also expressed in epidermal keratinocytes...
  16. pmc Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
    Annabell Bachem
    Molecular Immunology, Robert Koch Institute, 13353 Berlin, Germany
    J Exp Med 207:1273-81. 2010
    ..into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets...
  17. pmc Thrombomodulin is present in human plasma and urine
    H Ishii
    J Clin Invest 76:2178-81. 1985
    b>Thrombomodulin is an endothelial cell membrane protein that is a cofactor required for the rapid activation of plasma protein C...
  18. ncbi A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
    L Norlund
    Department of Laboratory Medicine, University of Lund, University Hospital, Sweden
    Thromb Haemost 77:248-51. 1997
    ..b>Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C ..
  19. ncbi Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease
    K K Wu
    Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
    Circulation 103:1386-9. 2001
    b>Thrombomodulin (TM) is expressed on the endothelial surface and plays an important role in vasoprotection...
  20. ncbi Synergistic effect of thrombomodulin promoter -33G/A polymorphism and smoking on the onset of acute myocardial infarction
    Yi Heng Li
    Department of Internal Medicine and Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Thromb Haemost 87:86-91. 2002
    b>Thrombomodulin is an endothelial cell surface receptor for thrombin. It plays an important role in the regulation of blood coagulation by decreasing thrombin activity and activating protein C...
  21. ncbi Characterization of thrombomodulin gene mutations of the 5'-regulatory region
    Fumie Nakazawa
    Atherosclerosis 164:385-7. 2002
  22. ncbi Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM pro
    Hidemi Ishii
    Department of Public Health, Showa Pharmaceutical University, Machida, Tokyo, Japan
    Blood 101:4765-74. 2003
    The present work investigated the mechanism for down-regulation of thrombomodulin (TM), an anticoagulant glycoprotein, on cultured umbilical vein endothelial cells (HUVECs) exposed to lipid extracts from oxidized low-density lipoprotein (..
  23. ncbi Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin
    Likui Yang
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 278:37465-70. 2003
    b>Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhances the catalytic efficiency of thrombin toward both protein C and protein C inhibitor (PCI) by 2-3 orders of magnitude...
  24. ncbi Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients <or =50 years of age
    Ting Hsing Chao
    Department of Internal Medicine, Tainan, Taiwan
    Am J Cardiol 93:204-7. 2004
    Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI)...
  25. ncbi A combination of two common thrombomodulin gene variants (-1208-1209TTdelTT and A455V) influence risk of coronary heart disease: a prospective study in men
    C J Konstantoulas
    British Heart Foundation Laboratories, Department of Medicine, Center for Cardiovascular Genetics, Royal Free and University College London Medical School, Rayne Building, London WC1E 6JF, UK
    Atherosclerosis 177:97-104. 2004
    ..study of myocardial infarction (MI), we identified risk associated with the combination of two variants in the thrombomodulin (TM) gene (-1208-1209TTdelTT and A455V) and an interaction with increased body mass index (BMI)...
  26. ncbi Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B
    Richard H Sohn
    Division of Cardiology, Johns Hopkins School of Medicine, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21287, USA
    Blood 105:3910-7. 2005
    ..Endothelial cell expression of thrombomodulin (TM), a key component of the anticoagulant protein C pathway, is potently inhibited by inflammatory cytokines...
  27. ncbi Association study of the thrombomodulin -33G>A polymorphism with coronary artery disease and myocardial infarction in Chinese Han population
    Jiangong Zhao
    Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road 167, Beijing 100037, China
    Int J Cardiol 100:383-8. 2005
    b>Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C...
  28. ncbi C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
    Bicheng Nan
    Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Surgery 138:212-22. 2005
    ..The objective of the present study was to determine the effect of CRP on the expression of thrombomodulin (TM) and the endothelial protein C receptor (EPCR) in human endothelial cells.
  29. doi JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter
    Yuanyuan Rong
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong, China
    FEBS Lett 584:852-8. 2010
    b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases...
  30. pmc Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition
    Yuan Chung Kao
    Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Mol Cell Biol 30:4767-85. 2010
    The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
  31. pmc Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism
    Linda Nocchi
    Department of Biochemistry, Biology, and Genetics, Polytechnic University of Marche, Ancona, Italy
    J Biol Chem 286:19478-88. 2011
    Malignant mesothelioma (MM) is often complicated by thromboembolic episodes, with thrombomodulin (TM) playing a critical role in the anticoagulant process...
  32. doi Thrombomodulin and its role in inflammation
    Edward M Conway
    Division of Hematology Oncology, Department of Medicine, Centre for Blood Research CBR, University of British Columbia, Vancouver, BC, Canada
    Semin Immunopathol 34:107-25. 2012
    The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
  33. doi Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro
    Ling Yuh Shyu
    Institute of Medicine, Chung Shan Medical University, Taiwan, ROC
    Thromb Res 129:43-9. 2012
    ..In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1)...
  34. doi Effects of shear stress on the gene expressions of endothelial nitric oxide synthase, endothelin-1, and thrombomodulin in human retinal microvascular endothelial cells
    Akihiro Ishibazawa
    Department of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan
    Invest Ophthalmol Vis Sci 52:8496-504. 2011
    ..Physiological shear stress is higher in the retinal microcirculatory network than in other organs. The effects of laminar shear stress on gene expression in human retinal microvascular endothelial cells (HRMECs) was investigated...
  35. doi Association of thrombomodulin gene polymorphisms and plasma thrombomodulin levels with acute myocardial infarction in north Indian patients
    Rupinder Dogra
    1Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Clin Appl Thromb Hemost 19:637-43. 2013
    This is the first study from north India that investigated the association of thrombomodulin (TM) polymorphisms with acute myocardial infarction (AMI) in 350 patients (≤ 40 years, n = 184 and ≥ 60 years, n = 166) and 350 matched-..
  36. doi Role of thrombomodulin gene in Indian population with coronary artery disease
    Swarup A Shah
    Research Laboratories, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    Biomarkers 17:610-7. 2012
    b>Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker.
  37. pmc Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection
    Meera R Gupta
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Respir Res 14:71. 2013
    ..In this study, we examined the effect of RSV on the functional response of primary mDC subsets (BDCA-1(+) and BDCA-3(+)) isolated from peripheral blood...
  38. pmc Thrombomodulin expression regulates tumorigenesis in bladder cancer
    Chun Te Wu
    Chang Gung University, College of Medicine, Taoyuan, Taiwan
    BMC Cancer 14:375. 2014
    The identification of potential tumor markers will help improve therapeutic planning and patient management. Thrombomodulin (TM) is a sensitive urothelial marker...
  39. ncbi Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function
    Gabriella Kunz
    Department of Haematology, Imperial College School of Medicine, London, United Kingdom
    Blood 99:3646-53. 2002
    Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored...
  40. ncbi Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation
    Marlies Van de Wouwer
    The Center for Transgene Technology and Gene Therapy, University of Leuven and the Flanders Interuniversity Institute for Biotechnology VIB, Belgium
    Arterioscler Thromb Vasc Biol 24:1374-83. 2004
    ..Most of these can be traced to the vasculature, where the systems most intimately interact. Thrombomodulin (TM), a cell surface-expressed glycoprotein, predominantly synthesized by vascular endothelial cells, is a ..
  41. ncbi Variations in the thrombomodulin and endothelial protein C receptor genes in couples with recurrent miscarriage
    M Kaare
    Folkhalsan Institute of Genetics, University of Helsinki, Finland
    Hum Reprod 22:864-8. 2007
    ..Loss of function of two of these genes, thrombomodulin (TM) and endothelial protein C receptor (EPCR), causes embryonic lethality in mice...
  42. ncbi Prospective study of the A455V polymorphism in the thrombomodulin gene, plasma thrombomodulin, and incidence of venous thromboembolism: the LITE Study
    N Aleksic
    Division of Hematology, University of Texas Medical School, Houston, TX 77030, USA
    J Thromb Haemost 1:88-94. 2003
    Plasma thrombomodulin (soluble TM; sTM) is considered to be a marker of endothelial injury, but a recent report indicated that the relationship of sTM with thrombosis is complex...
  43. ncbi Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:150-8. 2003
    Several immunohistochemical markers, among them calretinin, thrombomodulin (CD141), keratin 5, and mesothelin, have been documented or suggested as useful markers for positive identification of mesothelioma and to differentiate it from ..
  44. pmc Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 112:585-91. 2008
    Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from trophoblast cells of the mouse placenta causes a fatal arrest of placental morphogenesis...
  45. ncbi The thrombomodulin-protein C system is essential for the maintenance of pregnancy
    Berend Isermann
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
    Nat Med 9:331-7. 2003
    Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect in the placenta...
  46. pmc Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breast
    N B Teo
    Pathology Department, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Cancer 86:905-11. 2002
    ..were determined using morphometry and a panel of anti-endothelial antibodies (von Willebrand factor, CD31, CD141 and CD34) and related to the presence of invasive carcinoma and other histological features...
  47. ncbi Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source
    Dorthe Schmidt
    Clinic for Cardiovascular Surgery and Department of Surgical Research, University and University Hospital Zurich, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Circulation 116:I64-70. 2007
    ..A novel concept providing prenatally tissue engineered human autologous heart valves based on routinely obtained fetal amniotic fluid progenitors as single cell source is introduced...
  48. doi Peritubular capillary loss is ameliorated by ramipril or valsartan treatment
    Bin Zhang
    Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
    Microcirculation 15:337-48. 2008
    ..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection...
  49. ncbi Cryopreserved amniotic fluid-derived cells: a lifelong autologous fetal stem cell source for heart valve tissue engineering
    Dorthe Schmidt
    Clinic for Cardiovascular Surgery, Department of Surgical Research, University, University Hospital, Zurich, Switzerland
    J Heart Valve Dis 17:446-55; discussion 455. 2008
    ..In order to expand the versatility of these cells also for adult application, cryopreserved AFDC were investigated as a potential life-long available cell source for heart valve tissue engineering...
  50. doi Three DNA methylation epigenotypes in human colorectal cancer
    Koichi Yagi
    Genome Science Division, Department of Gastrointestinal Surgery, Research Center for Advanced Science and Technology, Translational Systems Biology and Medicine Initiative, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 16:21-33. 2010
    ..Our aim is to clarify DNA methylation epigenotypes of colorectal cancer more comprehensively...
  51. ncbi Surface antigens of human mesangial cells: impact of growth surface or IL-1alpha
    G Sengoelge
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wien, Austria
    Tissue Antigens 60:383-95. 2002
    ..58, 90, 106, 146, 147, 166; growth factor receptors: CD105, 140b; apoptosis related: CD95; hemostatis related: CD141, 142; miscellaneous: CD44, 109, 138, 151, 157, 165, and 11 nonclustered antigens) reacted with mesangial cells...
  52. pmc Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E910-7. 2008
    ..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation...
  53. ncbi Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense
    Y D Dean
    Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, GB
    Eur J Immunol 31:1370-81. 2001
    Phagocytic complement C1q receptor (C1qRp) and thrombomodulin (TM, CD141), are two key members of a novel family of lectin receptors involved in cell-cell interactions and innate immune host defense...
  54. ncbi Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages
    Geert R Verheyen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Toxicol In Vitro 18:377-91. 2004
    ..Our data indicate the multitude of biological processes potentially influenced by DEP...
  55. ncbi VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung
    A M Healy
    The Pulmonary Center, Boston University School of Medicine, Boston Massachusetts 02118, USA
    Dev Dyn 219:341-52. 2000
    ..Platelet endothelial cell adhesion molecule-1 (PECAM/CD31) and thrombomodulin (TM/CD141) immunolocalization demonstrate that vascular development occurs in lung cultures...
  56. ncbi Twelve loci from HSA10, HSA11 and HSA20 were comparatively FISH-mapped on river buffalo and sheep chromosomes
    L Iannuzzi
    National Research Council CNR, IABBAM, Laboratory of Animal Cytogenetics, Via Argine 1085, 80147 Naples Ponticelli, Italy
    Cytogenet Cell Genet 93:124-6. 2001
    ..Indirect comparisons between physical maps achieved on bovid chromosomes and those reported on HSA10, HSA11 and HSA20 were performed...
  57. ncbi Phenotypic differences between red pulp capillary and sinusoidal endothelia help localizing the open splenic circulation in humans
    Birte Steiniger
    Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 8, 35032, Marburg, Germany
    Histochem Cell Biol 128:391-8. 2007
    ..Double staining for CD34 and CD141 (thrombomodulin) revealed that capillary endothelia in the cords of the splenic red pulp and at the surface of follicles were ..
  58. doi FcεRI levels and frequencies of peripheral blood dendritic cell populations in allergic rhinitis
    Kristina Lundberg
    Department of Immunotechnology, Lund University, Lund, Sweden
    Hum Immunol 71:931-3. 2010
    ..In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses...
  59. ncbi Cytogenetic alignment of the bovine chromosome 13 genome map by fluorescence in-situ hybridization of human chromosome 10 and 20 comparative markers
    D S Gallagher
    Department of Animal Science, Texas A and M University, College Station 77843, USA
    Chromosome Res 7:115-9. 1999
    ..These FISH results anchor the BTA13 genome map from bands 14-23, and confirm the presence of a conserved HSA10 homologous synteny group on BTA13 centromeric to a HSA20 homologous segment...
  60. ncbi Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors
    Jennifer Brady
    Brain Inflammation and Immunity Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    J Neuropathol Exp Neurol 63:1274-83. 2004
    ..Its protein domain architecture is homologous to that of CD93 and thrombomodulin (CD141), suggesting a similar function in mediating cell-cell interactions...
  61. ncbi [Chiparray-based identification of gene expression in HUVECs treated with low frequency electric fields]
    D Ulrich
    Klinik für Plastische Chirurgie, Hand und Verbrennungschirurgie, Universitatsklinikum Aachen, Germany
    Handchir Mikrochir Plast Chir 38:149-55. 2006
    ..In this study, we report on IN VITRO studies performed to characterize gene expression profiles using a DNA-microarray in HUVECs (human umbilical vein endothelial cells) exposed to low frequency electrical current...
  62. doi Expression of blood dendritic cell antigens (BDCAs) by CD1a+ human pulmonary cells
    Maria Tsoumakidou
    Lung Pathology Unit, London SW3 6LY, UK
    Respir Med 103:935-8. 2009
    ..We investigated the expression of these antigens by isolated human pulmonary CD1a(+) DCs, namely Langerhan's cells...
  63. doi Assessment of physiological amplitude, duration, and magnitude of ECG T-wave alternans
    Laura Burattini
    Department of Biomedical, Electronics, and Telecommunication Engineering, Polytechnic University of Marche, 60131 Ancona, Italy
    Ann Noninvasive Electrocardiol 14:366-74. 2009
    ....
  64. doi Isolation of human blood DC subtypes
    Andrew J Kassianos
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 595:45-54. 2010
    ..CD11c(+) myeloid DC, which can be further subdivided into three subsets based on differential expression of CD1c, CD141 and CD16...
  65. doi Genetic aspects of ischemic stroke: coagulation, homocysteine, and lipoprotein metabolism as potential risk factors
    Sanja Stankovic
    Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade, Serbia
    Crit Rev Clin Lab Sci 47:72-123. 2010
    ..The data assembled could be very useful for further meta-analysis and for future clinical applications...
  66. doi Screening of the HLDA9 panel on peripheral blood dendritic cell populations
    Yitian Ding
    Mater Medical Research Institute, Aubigny Place, South Brisbane, Queensland, Australia
    Immunol Lett 134:161-6. 2011
    ..The CD11c(+) myeloid DC can be divided into populations by CD1c, CD16 and CD141 expression...
  67. ncbi Mouse models of thrombosis: thrombomodulin
    Hartmut Weiler
    Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Department of Physiology, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA
    Thromb Haemost 92:467-77. 2004
    This review describes animal models of TM-deficiency that cause thrombosis in mice. Thrombomodulin (TM) is a key component of the protein C anticoagulant pathway by facilitating the activation of protein C by thrombin...
  68. ncbi Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines
    Masayoshi Imura
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 241:213-20. 2006
    ..It was shown that aberrant methylation and demethylation were frequently observed in ovarian cancer cell lines, and these data will provide a basis for further epigenetic analysis in ovarian cancers...
  69. ncbi Correlation between thrombomodulin and severe preeclampsia: a summary
    Viroj Wiwanitkit
    Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Appl Thromb Hemost 14:99-101. 2008
    b>Thrombomodulin is a critical cofactor in the initiation of the protein C anticoagulant pathway...
  70. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..In contrast, the anti-inflammatory/anti-coagulant CD141/thrombomodulin increased markedly when IL-32 was silenced...
  71. doi Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome
    Tara K Maga
    Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 31:E1445-60. 2010
    ..5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD). Since aHUS is rare, mutation rate data in large patient cohorts are scarce...
  72. doi High levels of protein C are determined by PROCR haplotype 3
    M C Pintao
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Thromb Haemost 9:969-76. 2011
    ..Recently, we identified a locus on chromosome 20 determining high PC levels in a large Dutch pedigree with unexplained thrombophilia. Candidate genes in the LOD-1 support interval included FOXA2, THBD and PROCR...
  73. doi Evaluation of various endothelial biomarkers in ankylosing spondylitis
    Ali Taylan
    Department of Rheumatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
    Clin Rheumatol 31:23-8. 2012
    ..von Willebrand factor (vWF), soluble thrombomodulin (sTM), and urotensin (UT-II) were found to be significantly higher in the sera of the patients compared to the ..
  74. doi Small supernumerary marker chromosomes derived from chromosomes 6 and 20 in a woman with recurrent spontaneous abortions
    Narjes Guediche
    Universite Paris Sud, Service d Histologie Embryologie et Cytogénétique, APHP, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141 Clamart, France
    Eur J Med Genet 55:737-42. 2012
    ..This report underpins the necessity of array CGH for characterizing precisely sSMC and helping in genotype-phenotype correlations. Furthermore, a literature review on sSMC is included...
  75. ncbi Prevalence of thrombosis-related DNA polymorphisms in a healthy Greek population
    Christos Yapijakis
    Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece
    In Vivo 26:1095-101. 2012
    ..F12) C46T, plasma carboxypeptidase B2 (CPB2) C1040T, platelet glycoprotein Ib α polypeptide (GP1BA) VNTR, thrombomodulin (THBD) -A33G and protein Z (PROZ) - A13G have not...
  76. pmc Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β
    Chun I Yu
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunity 38:818-30. 2013
    ..Here, we analyzed, by using lung tissues from humans and humanized mice, the role of human CD1c(+) and CD141(+) DCs in determining the type of CD8(+) T cell immunity generated to live-attenuated influenza virus (LAIV) ..
  77. doi Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkers
    Cheng Jeng Tai
    Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, Republic of China
    Tumour Biol 35:47-54. 2014
    b>Thrombomodulin (TM) has been shown to regulate many physiological and pathological processes, including inflammation, thrombosis, and tumor progression...
  78. pmc Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets
    Masaaki Toda
    Department of Immunology, Mie University Graduate School of Medicine, Tsu Shi, Mie Ken, Japan
    PLoS ONE 8:e72392. 2013
    Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface...
  79. ncbi Preliminary assessment of differential expression of candidate genes associated with atherosclerosis
    Joan Blin
    Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia UPM
    Genes Genet Syst 88:199-209. 2013
    ..insulin receptor substrate 1 (IRS1), lipoprotein lipase (LPL), methylenetetrahydrofolate reductase (MTHFR), thrombomodulin (THBD), lecithin-cholesterol acyltransferase (LCAT), matrix metallopeptidase 9 (MMP9), low density lipoprotein ..
  80. pmc Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells
    Takashi Maejima
    Research Center for Advanced Science and Technology, The University of Tokyo, Meguro ku, Tokyo, Japan Tokyo New Drug Research Laboratories, Kowa Company Ltd, Higashimurayama, Tokyo, Japan
    PLoS ONE 9:e96005. 2014
    ..revealed that the atheroprotective genes induced with pitavastatin, such as nitric oxide synthase 3 (NOS3) and thrombomodulin (THBD), were suppressed by KLF4 knockdown...
  81. pmc Heterogeneity of stromal cells in the human splenic white pulp. Fibroblastic reticulum cells, follicular dendritic cells and a third superficial stromal cell type
    Birte S Steiniger
    Institute of Anatomy and Cell Biology, University of Marburg, Marburg, Germany
    Immunology 143:462-77. 2014
    ..partially overlapping shells of stromal cells exhibiting CD90 (Thy-1), MAdCAM-1, CD105 (endoglin), CD141 (thrombomodulin) and smooth muscle α-actin (SMA) with expression of CD90 characterizing the broadest shell and SMA the ..
  82. doi Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals
    Jussi Ryynänen
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    Mol Nutr Food Res 58:2036-45. 2014
    ..Vitamin D₃, its biologically most active metabolite 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), and the vitamin D receptor (VDR) are important for adipose tissue biology...
  83. doi Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expression
    Tsung Lin Cheng
    1 Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Invest Dermatol 135:1668-75. 2015
    Keratinocyte-expressed thrombomodulin (TM) and the released soluble TM (sTM) have been demonstrated to promote wound healing...
  84. pmc Circulating precursors of human CD1c+ and CD141+ dendritic cells
    Gaelle Breton
    Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065
    J Exp Med 212:401-13. 2015
    ..to earlier progenitors with greater developmental potential, the hpre-CDC is restricted to producing CD1c(+) and CD141(+) Clec9a(+) cDCs...
  85. pmc Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection
    Steven Kho
    Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Infect Immun 83:3224-32. 2015
    ..household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC (pDC), CD141(+), and CD1c(+) myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (of whom 15 ..
  86. doi Identification of Genetic Aberrations in Thrombomodulin Gene in Patients With Recurrent Venous Thromboembolism
    Abrar Ahmad
    1 Department of Clinical Sciences, Center for Primary Health Care Research, Skane University Hospital, Lund University, Lund, Sweden
    Clin Appl Thromb Hemost . 2017
    b>Thrombomodulin (THBD) serves as a cofactor for thrombin-mediated activation of anticoagulant protein C pathway. Genetic aberrations in THBD have been studied in arterial and venous thrombosis...
  87. doi The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes
    Yunlei Cao
    Fudan University, 130 Dong an Road, Shanghai 200032, China NPFPC Laboratory of Contraception and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China
    Gene 530:248-52. 2013
    ..study were to investigate the effects of polymorphisms in hemostasis-related genes antithrombin (SERPINC1), thrombomodulin (THBD), tissue factor pathway inhibitor (TFPI), factor V, factor II and annexin A5 (ANXA5), involved in ..
  88. doi Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease
    Andrew J Kassianos
    Conjoint Kidney Research Laboratory, Pathology Queensland, Queensland Institute of Medical Research, Level 9, Bancroft Centre, Herston 4006, Queensland, Australia
    Am J Physiol Renal Physiol 305:F1391-401. 2013
    ..We detected significantly greater numbers of total DCs as well as CD141(hi) and CD1c(+) myeloid DC (mDCs) subsets in diseased biopsies with interstitial fibrosis than diseased biopsies ..
  89. doi Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk
    Silvia Navarro
    Unidad de Bioquimica, Centro de Investigacion, Hospital Universitario La Fe, Valencia, Spain
    Arterioscler Thromb Vasc Biol 33:1435-40. 2013
    ..1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels...
  90. pmc Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation
    Carsten Carlberg
    School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e71042. 2013
    ..The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for ..
  91. ncbi Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p)
    D R Maglott
    American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852 1776, USA
    Mamm Genome 7:400-1. 1996
  92. pmc The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?
    B Steiniger
    Institute of Anatomy and Cell Biology, University of Marburg, Robert Koch Str 6, D 35033 Marburg, Germany
    Am J Pathol 159:501-12. 2001
    ..and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141)...
  93. ncbi Genetic risk for restenosis after coronary balloon angioplasty
    Hideki Horibe
    Department of Cardiology, Kosei Hospital, Anjo, Japan
    Atherosclerosis 174:181-7. 2004
    ..two polymorphisms (242C --> T in the NADH/NADPH oxidase p22 phox (p22-PHOX) gene and 2136C --> T in the thrombomodulin (THBD) gene) in men and two polymorphisms (584G --> A in the paraoxonase 1 (PON1) gene and 2445G --> A ..
  94. pmc Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C
    Likui Yang
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 103:879-84. 2006
    ..The binding of Ca(2+) to the 70-80 loop of protein C inhibits protein C activation by thrombin in the absence of thrombomodulin (TM), but the metal ion is required for activation in the presence of TM...
  95. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Here we show that activated protein C (APC) formation, which is regulated by endothelial thrombomodulin, is reduced in diabetic mice and causally linked to nephropathy...
  96. doi Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke
    Jean Marc Olivot
    INSERM U698 and Denis Diderot University Paris VII, Dept of Neurology and Stroke Center, Bichat University Hospital, Paris, France
    J Neurol 255:514-9. 2008
    b>Thrombomodulin is expressed at the surface of endothelial cells and controls thrombin generation and thrombin-induced platelets and vascular cell activation...
  97. doi Impaired binding of thrombin to thrombomodulin is associated with risk of deep vein thrombosis
    Etsuji Suehisa
    Laboratory for Clinical Investigation, Osaka University Hospital, Suita City, Osaka, Japan
    Thromb Res 123:85-92. 2008
    The complex of thrombin and thrombomodulin (TM) activates protein C, and impaired binding of thrombin to TM may be a risk factor for thrombosis...
  98. doi Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells
    I Chung Lo
    Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan, Republic of China
    Cardiovasc Res 81:771-9. 2009
    b>Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear...
  99. ncbi [Effect of C5a on expression of thrombomodulin in endothelial cells in vitro]
    Wei Fang
    Guangzhou Medical College, Guangzhou 510010, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:168-71. 2009
    To investigate the effect of C5a on the expression of thrombomodulin (TM) in human umbilical vein endothelial cells (HUVECs).
  100. pmc Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC
    Henning Lauterbach
    Department of Research Immunology, Bavarian Nordic GmbH, 82152 Martinsried, Germany
    J Exp Med 207:2703-17. 2010
    ..Human DCs expressing BDCA3 (CD141), which is considered to be the human counterpart of murine CD8α(+) DCs, also produced large amounts of ..
  101. pmc Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:502-10. 2011
    b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation...

Research Grants8

  1. NUTRITION ACADEMIC AWARD
    Michael Miller; Fiscal Year: 2004
    ..Compliance with ATP II and JNC VI recommendations will also be assessed. In addition, medical students' diets and blood lipid levels will be assessed and tracked. ..
  2. INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS
    Lloyd Mayer; Fiscal Year: 2007
    In this R-01 granting period we have identified an apoptotic protein isolated from the CD141/low CD16/high 43/HIV human macrophage hybridoma cell line...
  3. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
    ..We also found that thrombomodulin (TM), an endothelial membrane receptor that deactivates thrombin and accelerates activated protein C formation ..
  4. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
    ..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
  5. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
    ..g. to muscle tissue, or to other hematopoietic niches. ..
  6. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT MOSNIER; Fiscal Year: 2007
    ..I propose: 1) To characterize the formation of endothelial cell membrane receptor complexes between thrombomodulin, [unreadable] endothelial protein C receptor and protease activated receptor-1 required for APC generation and ..
  7. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..