Genomes and Genes
Gene Symbol: TGFBI
Description: transforming growth factor beta induced
Alias: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, transforming growth factor-beta-induced protein ig-h3, RGD-CAP, RGD-containing collagen-associated protein, beta ig-h3, betaig-h3, kerato-epithelin, transforming growth factor beta-induced 68kDa, transforming growth factor, beta-induced, 68kD
Publications240 found, 100 shown here
- Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitroR G LeBaron
Division of Life Sciences, University of Texas at San Antonio, USA
J Invest Dermatol 104:844-9. 1995..Finally, we show that recombinant beta IG-H3 supported attachment and spreading of dermal fibroblasts, suggesting that beta IG-H3 may function as an extracellular attachment protein in skin...
- [Arterial dysfunction after treatment of coarctation of the aorta]Y Aggoun
, 149, , 75743 Paris
Arch Mal Coeur Vaiss 94:785-9. 2001..of the common carotid artery (CCA) to define mechanical indexes: Cross sectional compliance (CSC), distensibility (CSD) and incremental elastic modulus (Einc) in each group...
- BIGH3 gene mutations and rapid detection in Korean patients with corneal dystrophyH S Kim
Laboratory of Ophthalmology and Visual Science, Catholic Research Institutes of Medical Science, Catholic University Medical College, Seoul, Korea
Cornea 20:844-9. 2001Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant corneal dystrophies. We sought to determine whether the BIGH3 gene mutation was responsible for corneal dystrophy in Korean patients.
- An atypical phenotype of Reis-Bücklers corneal dystrophy caused by the G623D mutation in TGFBIDandan Li
Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
Mol Vis 14:1298-302. 2008To characterize the molecular defects in the TGFBI gene in a Chinese family with an unusual phenotype of Reis-Bücklers corneal dystrophy (RBCD).
- A corneal dystrophy associated with transforming growth factor beta-induced Gly623Asp mutation an amyloidogenic phenotypeClaudia Auw-Haedrich
University Eye Hospital, Freiburg, Germany
Ophthalmology 116:46-51. 2009To present the light and electron microscopic findings of a unique corneal dystrophy never before described in a German family carrying the Gly623Asp Mutation of the TGFBI gene with late clinical onset.
- The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxelAhmed Ashour Ahmed
Functional Genomics of Drug Resistance Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Cancer Cell 12:514-27. 2007..Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic ..
- RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosisJung Eun Kim
Department of Biochemistry, Kyungpook National University School of Medicine, Taegu, Korea
Oncogene 22:2045-53. 2003..The anti-beta ig-h3 antibody blocks TGF-beta-induced apoptosis. Thus, beta ig-h3 may be important in regulating cell apoptosis by providing soluble RGD peptides...
- Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrinJung Eun Kim
Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
J Biol Chem 277:46159-65. 2002..This suggests that fas-1 domain-containing proteins may perform their biological functions by interacting with integrins...
- Clinical findings and treatments of granular corneal dystrophy type 2 (avellino corneal dystrophy): a review of the literatureKyung Eun Han
Department of Ophthalmology, Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seodaemun Ku, Seoul, Korea
Eye Contact Lens 36:296-9. 2010..To review the literature about clinical findings and treatments of granular corneal dystrophy type 2 (GCD2)...
- SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutationR V Basaiawmoit
Center for Insoluble Protein Structures inSPIN, iNANO Interdisciplinary Nanoscience Center, Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
J Mol Biol 408:503-13. 2011..The protein is of interest because mutations in the TGFBI gene encoding TGFBIp lead to corneal dystrophy (CD), a condition where protein aggregates within the cornea ..
- Frequent promoter hypermethylation of TGFBI in epithelial ovarian cancerSokbom Kang
Research Institute and Hospital, National Cancer Center, Goyang, Republic of Korea
Gynecol Oncol 118:58-63. 2010..Using pharmacologic unmasking and genome-wide differential methylation analysis, we identified a novel methylated gene in ovarian cancers...
- Downregulation of Betaig-h3 gene is causally linked to tumorigenic phenotype in asbestos treated immortalized human bronchial epithelial cellsYong L Zhao
Center for Radiological Research, College of Physicians and Surgeons, Joseph Mailman School of Public Health, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Oncogene 21:7471-7. 2002..The result strongly suggests that loss of Betaig-h3 expression is a frequent event in human cancer and causally related to acquisition of tumorigenic phenotype in asbestos-treated BEP2D cells...
- Elevation of urinary betaig-h3, transforming growth factor-beta-induced protein in patients with type 2 diabetes and nephropathySung Woo Ha
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700 422, Republic of Korea
Diabetes Res Clin Pract 65:167-73. 2004..These data show that urinary levels of betaig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy...
- TGFBI mutational analysis in a New Zealand population of inherited corneal dystrophy patientsAndrea L Vincent
Department of Ophthalmology, Faculty of Medical and Health Sciences, National Eye Centre, University of Auckland, Auckland, New Zealand
Br J Ophthalmol 94:836-42. 2010..Mutations in the transforming growth factor beta-induced (TGFBI) gene segregate with a wide range of phenotypically heterogeneous corneal dystrophies...
- Genotype-phenotype correlation of TGFBI corneal dystrophies in Polish patientsAnna K Nowińska
Department of Ophthalmology, District Railway Hospital, Katowice, Poland
Mol Vis 17:2333-42. 2011To analyze genotype-phenotype correlation in patients originating from Polish population with the transforming growth factor beta induced (TGFBI) corneal dystrophies.
- Extremely varied phenotypes in granular corneal dystrophy type 2 heterozygotesKyung Eun Han
Corneal Dystrophy Research Institute, Yonsei University College of Medicine, 50 Yonseiro, Seodaemun gu, Seoul, Korea
Mol Vis 18:1755-62. 2012To investigate the phenotypic variability of patients bearing the heterozygous R124H mutation in the TGFBI (transforming growth factor-beta-induced) gene that causes granular corneal dystrophy type 2 (GCD2).
- Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north IndiaPreeti Paliwal
Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi
Arch Ophthalmol 127:1373-6. 2009..To report Avellino corneal dystrophy and underlying R124H mutation in 2 families of Indian origin...
- TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cellsSeung Hee Lee
Kyungpook National University, Daegu, Republic of Korea
Cell Immunol 266:61-6. 2010....
- Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cellsYongliang Zhao
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Mol Carcinog 45:84-92. 2006..These observations demonstrate that downregulation of Betaig-h3 gene is a frequent event and related to the tumor progression in human lung cancer...
- TGFBI (BIGH3) gene mutations in German families: two novel mutations associated with unique clinical and histopathological findingsC Gruenauer-Kloevekorn
Department of Ophthalmology, Martin Luther University, Ernst Grube Strasse 40, 06097 Halle, Germany
Br J Ophthalmol 93:932-7. 2009To report the clinical, histopathological and immunohistochemical findings of two novel mutations within the TGFBI gene.
- Arg124Cys mutation of the TGFBI gene in 2 Chinese families with Thiel-Behnke corneal dystrophyLiu Chang
Beijing Tongren Ophthalmic Center, Beijing Institute of Ophthalmology, Capital University of Medical Sciences, Beijing, China
Arch Ophthalmol 127:641-4. 2009To analyze transforming growth factor beta-induced (TGFBI) gene mutations in 2 Chinese families with Thiel-Behnke corneal dystrophy (TBCD).
- TGFBI gene mutation in a Chinese pedigree with Reis-Bücklers corneal dystrophyQingfeng Liang
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Ophthalmic Physiol Opt 32:74-80. 2012To characterize the molecular defects in the TGFBI gene in a Chinese family with Reis-Bücklers corneal dystrophy (RBCD), and to study the relationship between the gene mutations and the clinical manifestations.
- The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectinPaul C Billings
Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 277:28003-9. 2002..Our results identify FN and Col I as two ligands of (beta)ig-h3 in the ECM...
- Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophyM Okada
Department of Ophthalmology, Osaka University Medical School, Japan
Am J Ophthalmol 126:535-42. 1998..To see whether there was a genetic basis for these phenotypic variations, we analyzed beta ig-h3, the gene that codes for kerato-epithelin and that contains a mutation (Arg555Gln) that causes RBCD...
- Heterogeneity in granular corneal dystrophy: identification of three causative mutations in the TGFBI (BIGH3) gene-lessons for corneal amyloidogenesisH S Stewart
Department of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester, UK
Hum Mutat 14:126-32. 1999Six autosomal dominant corneal dystrophies are caused by mutations in the TGFBI (BIGH3) gene on chromosome 5q31: three types of lattice corneal dystrophy (LCD), including type I and type IIIA, granular, Avellino (ACD), and Reis-Bucklers...
- A novel variant of granular corneal dystrophy caused by association of 2 mutations in the TGFBI gene-R124L and DeltaT125-DeltaE126P Dighiero
Laboratoire de Biochimie et Genetique Moleculaire, 123 boulevard du Port Royal, 75014 Paris, France
Arch Ophthalmol 118:814-8. 2000To characterize the molecular defect in the TGFBI gene in a French family affected with an atypical granular corneal dystrophy.
- Histologic phenotype-genotype correlation of corneal dystrophies associated with eight distinct mutations in the TGFBI geneP Dighiero
Department of Ophthalmology, Hotel Dieu Hospital, Paris, France
Ophthalmology 108:818-23. 2001..To establish a phenotype-genotype correlation of various autosomal-dominant corneal dystrophies among French subjects...
- Late-onset form of lattice corneal dystrophy caused by leu527Arg mutation of the TGFBI geneK Hirano
Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
Cornea 20:525-9. 2001To report two Japanese patients who were clinically diagnosed with late-onset and sporadic lattice corneal dystrophy (LCD) in whom a Leu527Arg mutation in the TGFBI gene was found.
- Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAMMark Aitkenhead
Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697, USA
Microvasc Res 63:159-71. 2002..These data expand the suite of genes implicated in vascular remodeling and angiogenesis...
- Lattice corneal dystrophy associated with the Ala546Asp and Pro551Gln missense changes in the TGFBI geneAnthony J Aldave
Cornea Service, The Jules Stein Eye Institute, 100 Stein Plaza, Los Angeles, CA 90095, USA
Am J Ophthalmol 138:772-81. 2004To report a phenotypic variant of lattice corneal dystrophy associated with two missense changes, Ala546Asp and Pro551Gln, in the transforming growth factor-beta-induced gene (TGFBI).
- TGFBI gene mutation analysis in families with hereditary corneal dystrophies from UkraineV M Pampukha
Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine, Kiev, Ukraine
Ophthalmologica 218:411-4. 2004In our study, 5 previously reported mutations of the TGFBI gene - R124C, R124H, R124L (exon 4), R555W, R555Q (exon 12) - were analyzed using polymerase chain reaction followed by restriction digestion in 48 individuals from 19 unrelated ..
- Beta ig-h3 mediates osteoblast adhesion and inhibits differentiationNarendra Thapa
Institute of Cell and Matrix Biology Research, Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700 422, South Korea
Bone 36:232-42. 2005..We suggest that these interacting integrins may play an important role in betaig-h3-mediated inhibition of osteoblast differentiation...
- A unique corneal dystrophy of Bowman's layer and stroma associated with the Gly623Asp mutation in the transforming growth factor beta-induced (TGFBI) geneAnthony J Aldave
Cornea Service, Jules Stein Eye Institute, University of California, Los Angeles, California 90095, USA
Ophthalmology 112:1017-22. 2005To report a unique corneal dystrophy characterized by deposits at Bowman's layer and stromal lattice lines associated with the Gly623Asp missense mutation in the transforming growth factor beta-induced (TGFBI) gene.
- The TGFBI A546D mutation causes an atypical type of lattice corneal dystrophyVicente Correa-Gomez
Research Unit, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico
Mol Vis 13:1695-700. 2007To report the clinical, molecular, and histopathological features of a distinct transforming growth factor-beta-induced (TGFBI) gene-linked amyloidotic corneal dystrophy exhibiting an unusual lattice pattern.
- Spontaneous and inheritable R555Q mutation in the TGFBI/BIGH3 gene in two unrelated families exhibiting Bowman's layer corneal dystrophyXinping C Zhao
Department of Ophthalmology and Visual Science and Hermann Eye Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
Ophthalmology 114:e39-46. 2007Bowman's layer corneal dystrophies (CDBs) include 2 distinct types: CDB1, or Reis-Bücklers (RBCD), and CDB2, or Thiel-Behnke (TBCD)...
- Phenotype associated with the H626P mutation and other changes in the TGFBI gene in Czech familiesPetra Liskova
Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, UK
Ophthalmic Res 40:105-8. 2008To evaluate mutations in the transforming-growth-factor-beta-induced (TGFBI) gene in patients of Czech origin with autosomal dominant corneal dystrophies.
- A novel phenotype-genotype relationship with a TGFBI exon 14 mutation in a pedigree with a unique corneal dystrophy of Bowman's layerCatherine E Wheeldon
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Mol Vis 14:1503-12. 2008..CDB) belongs to a group of dystrophies associated with mutations in the transforming growth factor-beta-induced (TGFBI) gene...
- A novel mutation I522N within the TGFBI gene caused lattice corneal dystrophy IChunmei Zhang
Department of Ophthalmology, Harbin Medical University The 2nd Affiliated Hospital, Harbin, China
Mol Vis 15:2498-502. 2009To identify mutations within the TGFBI gene in a Chinese family with lattice corneal dystrophy type I (LCD I).
- cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-betaJ Skonier
Bristol Myers Squibb, Seattle, WA 98121
DNA Cell Biol 11:511-22. 1992..Since beta ig-h3 is induced in several cell lines whose proliferation is affected by TGF-beta 1, it may be involved in mediating some of the signals of this multifunctional growth modulator...
- beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude miceJ Skonier
Bristol Myers Squibb, Pharmaceutical Research Institute Seattle, WA 98121
DNA Cell Biol 13:571-84. 1994..The corresponding mouse beta ig-h3 gene was mapped to mouse chromosome 13 region B to C1, which confirms a region of conservation on human chromosome 5 and mouse chromosome 13. We suggest that this protein be named p68 beta ig-h3...
- cDNA from human ocular ciliary epithelium homologous to beta ig-h3 is preferentially expressed as an extracellular protein in the corneal epitheliumJ Escribano
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06510
J Cell Physiol 160:511-21. 1994....
- Three autosomal dominant corneal dystrophies map to chromosome 5qE M Stone
Department of Ophthalmology, University of Iowa College of Medicine, Iowa City 52242
Nat Genet 6:47-51. 1994..The maximum combined lod score using all 114 affected patients was 28.6 with marker D5S393. None of the 14 known human amyloid-associated genes map to chromosome 5...
- Kerato-epithelin mutations in four 5q31-linked corneal dystrophiesF L Munier
Unit of Molecular Genetics, CHUV, Lausanne, Switzerland
Nat Genet 15:247-51. 1997Granular dystrophy Groenouw type I (CDGG1), Reis-Bücklers (CDRB), lattice type I (CDL1) and Avellino (ACD) are four 5q31-linked human autosomal dominant corneal dystrophies...
- Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagenK Hashimoto
Department of Removal Prosthodontics, School of Dentistry, Hiroshima University, Japan
Biochim Biophys Acta 1355:303-14. 1997..Since RGD-CAP transcripts were found in most tissues, this novel collagen-binding protein may play an important role in cell-collagen interactions in various tissues including developing cartilage...
- Mutation hot spots in 5q31-linked corneal dystrophiesE Korvatska
Unit of Molecular Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Am J Hum Genet 62:320-4. 1998Mutations in the BIGH3 gene on chromosome 5q31 cause four distinct autosomal dominant diseases of the human cornea: granular (Groenouw type I), Reis-Bücklers, lattice type I, and Avellino corneal dystrophies...
- A kerato-epithelin (betaig-h3) mutation in lattice corneal dystrophy type IIIAS Yamamoto
Am J Hum Genet 62:719-22. 1998
- Granular corneal dystrophy with homozygous mutations in the kerato-epithelin geneM Okada
Department of Ophthalmology, Osaka University Medical School, Suita, Japan
Am J Ophthalmol 126:169-76. 1998..Three members of the family were affected with a severe placoid type of corneal dystrophy. To determine the relationship between gene mutations and phenotypic variations of the disease, we analyzed the kerato-epithelin gene...
- A new L527R mutation of the betaIGH3 gene in patients with lattice corneal dystrophy with deep stromal opacitiesK Fujiki
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Hum Genet 103:286-9. 1998..We conclude that there are now at least six different mutations that have been detected in the betaIGH3 gene on chromosome 5q31 and that lead to corneal dystrophy...
- A common beta ig-h3 gene mutation (delta f540) in a large cohort of Sardinian Reis Bücklers corneal dystrophy patients. Mutations in brief no. 180. OnlineC Rozzo
Istituto di Genetica Molecolare, C N R, Alghero, Italy
Hum Mutat 12:215-6. 1998..Recently RBCD, together with lattice corneal dystrophy type I (LCDI), granular corneal dystrophy (CDGG1) and Avellino stromal dystrophy (ASD), all mapped on 5q31, were found to be associated to four different mutations ..
- Corneal amyloidosis caused by Leu518Pro mutation of betaig-h3 geneK Hirano
Department of Ophthalmology, Nagoya University School of Medicine, Aichi, Japan
Br J Ophthalmol 84:583-5. 2000..To report a Japanese family diagnosed clinically as having lattice corneal dystrophy type I (LCDI) in which a Leu518Pro mutation in the betaig-h3 gene and not the R124C mutation reported previously was found...
- Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in JapanY Mashima
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
Am J Ophthalmol 130:516-7. 2000To evaluate the incidence of BIGH3 gene mutations in 164 unrelated Japanese patients with corneal stromal dystrophies with an autosomal dominant trait.
- Corneal dystrophies in JapanK Fujiki
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
J Hum Genet 46:431-5. 2001..These four diseases were shown, in a Caucasian series, to result from different missense mutations in the TGFBI (BIGH3, keratoepithelin) gene...
- R124C mutation of the betaIGH3 gene leads to remarkable phenotypic variability in a Greek four-generation family with lattice corneal dystrophy type 1Y Hellenbroich
Institut fur Humangenetik, Universitatsklinikum Lubeck, Deutschland
Ophthalmologica 215:444-7. 2001..The resulting data revealed no association with the variable clinical course...
- Molecular properties of wild-type and mutant betaIG-H3 proteinsJung Eun Kim
Department of Biochemistry, School of Medicine, Kyungpook National University, 101 Dongin dong, Jung Gu, Taegu, 700 422 Korea
Invest Ophthalmol Vis Sci 43:656-61. 2002..To understand the mechanisms of protein deposits in 5q31-linked corneal dystrophies, the molecular properties of betaIG-H3 and the effects of mutation on these properties were studied in vitro...
- BIGH3 mutation spectrum in corneal dystrophiesFrancis L Munier
Hopital Jules Gonin, Department of Ophthalmology, Lausanne, Switzerland
Invest Ophthalmol Vis Sci 43:949-54. 2002To investigate the molecular pathology underlying BIGH3-related corneal dystrophies (CDs) and to further delineate genotype-phenotype specificity.
- Clinical outcome of eight BIGH3-linked corneal dystrophiesPierre Ellies
Department of Ophthalmology, Hopital Hotel Dieu de Paris, 1 Place du Parvis Notre Dame, 75004 Paris, France
Ophthalmology 109:793-7. 2002To determine whether the mutational pattern of BIGH3-linked corneal dystrophies (CDs) can accurately predict the clinical course of the disease and be helpful in planning adequate surgical treatment.
- Allelic homogeneity due to a founder mutation in Japanese patients with lattice corneal dystrophy type IIIAKaoru Tsujikawa
Department of Ophthalmology, Osaka University Medical School, Japan
Am J Med Genet 113:20-2. 2002Lattice corneal dystrophies (LCDs) are caused by mutations of the transforming growth factor beta-induced gene (TGFBI, formerly betaig-h3). LCD type IIIA (LCDIIIA) has been reported mostly from Japan...
- Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrinMi Ok Kim
Graduate School of East West Medical Science, Kyung Hee University, 1 Seochun, Yong In 449 701, South Korea
Neurosci Lett 336:93-6. 2003....
- A novel nonsense mutation with a compound heterozygous mutation in TGFBI gene in lattice corneal dystrophy type ITohru Sakimoto
Department of Ophthalmology, Nihon University, School of Medicine, Tokyo, Japan
Jpn J Ophthalmol 47:13-7. 2003We examined transforming growth factor beta-induced (TGFBI) gene mutations in a family with lattice corneal dystrophy type I.
- Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effectJu Ock Nam
Cell and Matrix Biology National Research Laboratory, Department of Biochemistry, Kyungpook National University School of Medicine, Taegu 700 422, Korea
J Biol Chem 278:25902-9. 2003..Our results reveal that betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and, therefore, may regulate angiogenesis...
- Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrilsEric Hanssen
Department of Pathology, University of Adelaide, South Australia, 5005, Australia
J Biol Chem 278:24334-41. 2003..Overall the study supports the concept that betaig-h3 is extensively associated with collagen VI in some tissues and that it plays an important modulating role in collagen VI microfibril function...
- A novel mutation of the TGFBI gene found in a Vietnamese family with atypical granular corneal dystrophyNguyen Thanh Ha
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
Jpn J Ophthalmol 47:246-8. 2003Mutation of the human transforming growth factor beta-induced (TGFBI) gene causes granular corneal dystrophy (GCD) in various ethnic groups...
- Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucoseSuk Hee Lee
Cell and Matrix Biology, National Research Laboratory, Kyungpook National University, Taegu, Korea
Kidney Int 64:1012-21. 2003..TGF-beta is believed to be involved in the development of diabetic nephropathy and thus we have assessed the possibility that betaig-h3 may be a downstream molecule in this pathogenic process...
- Lattice corneal dystrophy type I without typical lattice lines: role of mutational analysisShigeo Yoshida
Department of Ophthalmology, Kyushu University Graduate School of Medicine, Fukuoka, Japan
Am J Ophthalmol 137:586-8. 2004..To describe a Japanese patient with lattice corneal dystrophy type I (LCD I) who lacked the typical lattice lines...
- Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied familyGordon K Klintworth
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 45:1382-8. 2004..To determine the genetic basis for lattice corneal dystrophy (LCD) in an extensively studied family...
- Polymorphic corneal amyloidosis: a disorder due to a novel mutation in the transforming growth factor beta-induced (BIGH3) geneDavid E Eifrig
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 111:1108-14. 2004..To characterize the clinicopathologic phenotype as well as the molecular genetic basis of an autosomal dominant form of corneal amyloidosis...
- Unusual phenotype of an individual with the R124C mutation in the TGFBI geneNaoyuki Morishige
Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube, Japan
Arch Ophthalmol 122:1224-7. 2004
- TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patientsS V V Kalyana Chakravarthi
Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
Invest Ophthalmol Vis Sci 46:121-5. 2005To identify mutations in the TGFBI gene in Indian patients with lattice corneal dystrophy (LCD) or granular corneal dystrophy (GCD) and to look for genotype-phenotype correlations.
- Novel mutation (V505D) of the TGFBI gene found in a Chinese family with lattice corneal dystrophy, type IXin Tian
Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
Jpn J Ophthalmol 49:84-8. 2005To report a novel V505D mutation of the human transforming growth factor beta-induced (TGFBI) gene found in a Chinese family with lattice corneal dystrophy, type I (LCDI).
- Genotype-phenotype correlation in 2 Indian families with severe granular corneal dystrophyChitra Kannabiran
Kallam Anji Reddy Molecular Genetics Laboratory and Ophthalmic Pathology Service, Professor Brien Holden Eye Research Centre, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad 500 034, India
Arch Ophthalmol 123:1127-33. 2005..To determine genotypes in 2 Indian families with severe granular corneal dystrophy, to document clinical and histopathologic features, and to attempt a genotype-phenotype correlation...
- TGFBI gene mutations in Brazilian patients with corneal dystrophyH P Solari
Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
Eye (Lond) 21:587-90. 2007To investigate the transforming growth factor beta-induced gene (TGFBI) mutations in Brazilian patients with corneal dystrophy and to evaluate the phenotype-genotype correlation in these patients.
- Lattice corneal dystrophy type III in patients with a homozygous L527R mutation in the TGFBI geneTomoyo Funayama
Jpn J Ophthalmol 50:62-4. 2006
- A subset of patients with epithelial basement membrane corneal dystrophy have mutations in TGFBI/BIGH3Sandrine Boutboul
Centre de Recherche Thérapeutique en Ophtalmologie CERTO, Faculté Necker Enfants Malades, Paris, France
Hum Mutat 27:553-7. 2006..as well as the analysis of single affected individuals; we identified two different point mutations in the TGFBI/BIGH3 genes, genes known to be associated with other corneal dystrophies...
- [A research on TGFBI gene mutations in Chinese families with corneal dystrophies]Yan hua Qi
Department of Ophthalmology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150086 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:310-2. 2006To identify what kind of TGFBI gene mutation happening to Chinese patients with corneal dystrophies.
- A novel H572R mutation in the transforming growth factor-beta-induced gene in a Thai family with lattice corneal dystrophy type ILa ongsri Atchaneeyasakul
Department of Ophthalmology, Siriraj Hospital Mahidol University, Bangkok, Thailand
Jpn J Ophthalmol 50:403-8. 2006To describe a large Thai family with lattice corneal dystrophy (LCD) type I and to determine whether this LCD is associated with mutations within the transforming growth factor-beta-induced (TGFBI) gene.
- A novel variant lattice corneal dystrophy caused by association of mutation (V625D) in TGFBI geneXin Tian
Department of Ophthalmology, Third Hospital, Peking University, Beijing, China
Am J Ophthalmol 144:473-5. 2007To characterize the molecular defect in the TGFBI gene in a Chinese family affected with an atypical lattice corneal dystrophy.
- Keratoepithelin reverts the suppression of tissue factor pathway inhibitor 2 by MYCN in human neuroblastoma: a mechanism to inhibit invasionJuergen Becker
Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Universitatsmedizin Gottingen, D 37075 Gottingen, Germany
Int J Oncol 32:235-40. 2008..Recently we have demonstrated that keratoepithelin (BIGH3, TGFBI) expression significantly reduces proliferation and invasion of neuroblastomas in vitro and in vivo...
- Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasationChaoyu Ma
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genes Dev 22:308-21. 2008..Here we report that elevated expression of betaig-h3/TGFBI (transforming growth factor, beta-induced), an extracellular matrix protein secreted by colon cancer cells, is ..
- Role of BIGH3 R124H mutation in the diagnosis of Avellino corneal dystrophyV Huerva
Ophthalmology Department, University Hospital Arnau de Vilanova, Lleida, University of Lleida, IRB Lleida Spain
Eur J Ophthalmol 18:345-50. 2008..To report the presence of the R124H mutation in two Spanish families with Avellino corneal dystrophy (ACD)...
- Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) genePablo Romero
Depto de Oftalmologia, Hospital Clínico José Joaquín Aguirre, Universidad de Chile, Santiago, Chile
Mol Vis 14:829-35. 2008..To report the clinical, ophthalmic, and genetic characteristics for lattice corneal dystrophy type I (LCDI) in a Chilean family...
- An R124C mutation in TGFBI caused lattice corneal dystrophy type I with a variable phenotype in three Chinese familiesZhe Liu
Department of Ophthalmology, Medical College of Zhejiang University, Hangzhou, China
Mol Vis 14:1234-9. 2008..A genetic and clinical study of three unrelated Chinese pedigrees with a variable phenotype of lattice corneal dystrophy type I (LCD I)...
- p.Ala546 > Asp and p.Arg555 > Trp mutations of TGFBI gene and their clinical manifestations in two large Chinese families with granular corneal dystrophy type IPing Yu
Department of Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, People s Republic of China
Genet Test 12:421-5. 2008..Exons 4, 11, 12, and 14 of the human transforming growth factor beta-induced gene (TGFBI, formerly designated BIGH3) were amplified by PCR, scanned for mutations using the single-strand conformation polymorphism method, and the ..
- Reduced penetrance in familial Avellino corneal dystrophy associated with TGFBI mutationsWenping Cao
Eye Hospital, The First Affiliated Hospital, Harbin Medical University, Harbin, China
Mol Vis 15:70-5. 2009..To characterize the clinical phenotype, histopathological features, and molecular genetic basis of an Avellino corneal dystrophy (ACD) in a Chinese family...
- Clinical and genetic features of TGFBI-linked corneal dystrophies in Mexican population: description of novel mutations and novel genotype-phenotype correlationsJuan Carlos Zenteno
Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
Exp Eye Res 89:172-7. 2009..Most CDs are inherited in an autosomal dominant fashion and mutations in the TGFBI gene at chromosome 5q31 cause the majority of CDs affecting the stromal layer...
- Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosomeBong Yoon Kim
Corneal Dystrophy Research Institute and Department of Ophthalmology, South Korea
J Biol Chem 284:19580-91. 2009..The 5q31-linked corneal dystrophies are commonly caused by mutations in the TGFBI (transforming growth factor-beta-induced) gene...
- Novel and known mutations of TGFBI, their genotype-phenotype correlation and structural modeling in 3 Chinese families with lattice corneal dystrophyXingwu Zhong
Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, P R China
Mol Vis 16:224-30. 2010To report novel transforming growth factor beta-induced (TGFBI) mutations responsible for lattice corneal dystrophy (LCD), the associated genotype-phenotype correlation, and structural changes in the mutant proteins in three Chinese ..
- Genotype of lattice corneal dystrophy (R124C mutation in TGFBI) in a patient presenting with features of avellino corneal dystrophySean L Edelstein
Saint Louis University Eye Institute, Saint Louis University School of Medicine, Saint Louis, MO, USA
Cornea 29:698-700. 2010..To present a patient with a genotype usually associated with lattice corneal dystrophy but with clinical and histopathologic features of advanced Avellino corneal dystrophy...
- Analysis of TGFBI gene mutations in Chinese patients with corneal dystrophies and review of the literatureJuhua Yang
Biomedical Engineering Center, Fujian Medical University, Fuzhou, Fujian, China
Mol Vis 16:1186-93. 2010To analyze human transforming growth factor b-induced (TGFBI) gene mutations in Chinese patients with corneal dystrophies (CDs).
- TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophiesPreeti Paliwal
Laboratory of Cyto Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
Mol Vis 16:1429-38. 2010..of corneal dystrophy patients from North India for mutations in the transforming growth factor beta induced (TGFBI) gene, to correlate genotypes to phenotypes, to describe structural implications of various mutations on protein ..
- Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIpDhara A Patel
Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
Cornea 29:1215-22. 2010..We investigated the presence of these deposits in other TGFBI mutations and the use of Thioflavin-T (ThT), a fluorescent amyloid stain for characterizing corneal amyloid ..
- Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIpKasper Runager
Center for Insoluble Protein Structures, Department of Molecular Biology, Aarhus University, 8000 Aarhus, Denmark
J Biol Chem 286:4951-8. 2011Mutations in the human TGFBI gene encoding TGFBIp have been linked to protein deposits in the cornea leading to visual impairment. The protein consists of an N-terminal Cys-rich EMI domain and four consecutive fasciclin 1 (FAS1) domains...
- βig-h3 regulates store-operated Ca2+ entry and promotes the invasion of human hepatocellular carcinoma cellsYun shan Guo
Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, State Key Discipline of Cell Biology, Fourth Military Medical University, Xian 710032, Peoples Republic of China
Cell Biol Int 35:811-7. 2011..Our findings suggest that the expression of βig-h3 might play an important role in the regulation of store-operated Ca2+ entry to increase the invasive potential of HCC cells...
- Genotype-phenotype correlations of TGFBI p.Leu509Pro, p.Leu509Arg, p.Val613Gly, and the allelic association of p.Met502Val-p.Arg555Gln mutationsFlorence Niel-Butschi
INSERM, U1016, Institut Cochin, CNRS, UMR 8104, Universite Paris Descartes, Paris, France
Mol Vis 17:1192-202. 2011Investigate the genotype-phenotype correlations for five TGFBI (transforming growth factor, beta-induced) mutations including one novel pathogenic variant and one complex allele affecting the fourth FAS1 domain of keratoepithelin, and ..
- Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI geneHenrik Karring
Institute of Chemical Engineering, Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Alle 1, DK 5230 Odense M, Denmark
Exp Eye Res 96:163-70. 2012..lattice corneal dystrophy (LCD) are associated with mutations in the transforming growth factor beta induced gene (TGFBI)...
- Human U87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2Jie Ma
Department of Neurosurgery, Tangdu Hospital, Forth Military Medical University, Xi an, China
PLoS ONE 7:e37297. 2012..Our data showed that βig-h3 co-localized with integrin α5β1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule...
- Cat scratch disease and acquired immunodeficiency disease: diagnosis by transmission electron microscopyJ G Guccion
Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC, USA
Ultrastruct Pathol 20:195-202. 1996..The diagnosis of cat scratch disease (CSD) became apparent only after transmission electron microscopic study of the lymph node revealed clusters of small, ..
- [Serological cross-reaction among Bartonella henselae, Chlamydia pneumoniae and Coxiella burnetii by indirect fluorescence antibody method]H Tsuneoka
Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
Kansenshogaku Zasshi 75:406-10. 2001..burnetii by indirect fluorescence antibody (IFA) method, using sera from 8 patients with cat scratch disease (CSD), 13 patients with C. pneumoniae infection and 12 patients with acute Q fever. B...
- Downregulation of human polymorphonuclear cell activities exerted by microorganisms belonging to the alpha-2 subgroup of Proteobacteria (Afipia felis and Rochalimaea henselae)D Fumarola
Institutes of Medical Microbiology, General Pathology, University of Bari, Italy
Immunopharmacol Immunotoxicol 16:449-61. 1994..A. falis has been previously proposed as the causative agent of Cat Scratch Disease (CSD), but several recent lines of evidence attribute a major role to R. henselae...
- [A study on wounds caused by cats as basic materials of cat scratch disease]Y Arashima
Department of Clinical Pathology, Nihon University School of Medicine
Kansenshogaku Zasshi 68:734-9. 1994..Their injuries clearly differed from those of the other groups. In our survey 33 cases were suspected to have CSD; 19 of 102 veterinarians, 4 of 45 veterinary technicians, 2 of 517 students of veterinary college, 1 of 400 ..
- [Bartonella henselae as a cause of optical nerve neuritis]Dragan Veselinović
Klinicki centar, Klinika za ocne bolesti, Nis, Srbija
Vojnosanit Pregl 63:971-4. 2006..included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (CSD)...
- MOLECULAR CHARACTERIZATION OF ROCHALIMAEA ANTIGENSBurt Anderson; Fiscal Year: 1999..proteins; and 3) evaluating the recombinant antigens as diagnostic reagents for BA and cat-scratch disease (CSD). The basic approach will be to screen recombinant gene libraries of R. henselae and R...
- Terrence J Sejnowski; Fiscal Year: 2016..detailed models at the biophysical level to recordings from humans at the level of current source density analysis (CSD) recordings from depth electrodes;and 2) relate large scale reduced models of cortical circuits to EEG and MEG ..
- ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIESAndrew J W Huang; Fiscal Year: 2011b>bIGH3 (keratoepithelin) is a constituent of the extracellular matrix (ECM) responsible for cell adhesion...
- William C Sessa; Fiscal Year: 2016..the binding of Cav-1 to eNOS from its inhibitory function using mutagenesis of the caveolin scaffolding domain (CSD) and have developed a novel cell permeable, eNOS activator peptide and a mutant form of Cav-1 (F92A Cav-1) that ..
- Elena Tourkina; Fiscal Year: 2016..of caveolin-1 as a key target in interstitial lung disease was validated using the caveolin-1 scaffolding domain (CSD) peptide, a peptide which mimics the function of full-length caveolin-1...
- Frank Porreca; Fiscal Year: 2014..unknown, an important theory suggests that migraine may occur as a consequence of cortical spreading depression (CSD)...
- Xinjun Zhu; Fiscal Year: 2014..of NHE3 at a polymorphic site R474K in 2 of 3 patients with chronic diarrhea due to congenital sodium diarrhea (CSD) and this mutant failed to respond to dexamethasone...
- Phase II Study of Imatinib Mesylate in Patients with Inoperable Melanoma Gary K Schwartz; Fiscal Year: 2010..skin on the palms and soles (acral melanomas), on mucosal membranes, and from skin with chronic sun-induced damage (CSD) have distinctive patterns of chromosomal alterations as compared with the more common subtypes of melanoma arising ..
- Robert C Gorman; Fiscal Year: 2016..therapeutic approaches to limit infarct expansion early after MI will be studied: heart wrapping with the Acorn CSD(R), infarct reperfusion and calcium hydroxyapatite microsphere gel injection...
- NINA REDA SALAMA; Fiscal Year: 2016..first experimental support for this theory with the characterization of four cell shape determining genes (csd1, csd2, csd3, ccmA) that promote helical cell curvature and twist through changes in cell wall peptidoglycan (PG) ..
- Activation of the Trigeminovascular PathwayRami Burstein; Fiscal Year: 2011Activation of the trigeminovascular pathway: functional relationship with CSD, dural mast cells,and parasympathetic innervation of the dura...
- Sex differences in the basic pathophysiology of migraineKEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2011..We propose to study the role of the female sex hormones estrogen and progesterone in cortical spreading depression (CSD), the event thought to underlie certain forms of migraine...
- SUSAN ELLIS-WEISMER; Fiscal Year: 2016There is a critical shortage of new PhD's in the field of Communication Sciences and Disorders (CSD)...
- Colles Price; Fiscal Year: 2015..Furthermore, miR-9's proposed target gene TGFBI, a known tumor suppressor in solid malignancies, is not expressed in MLL-leukemias...
- Neural &Vascular Dysfunction As Mechanisms of Injury in Genetic Migraine ModelsCenk Ayata; Fiscal Year: 2012..migraine expressing human mutations in implicated genes, as well as data implicating cortical spreading depression (CSD) in migraine aura...
- Caveolin-1 regulation of altered functions of scleroderma fibrocytesElena Tourkina; Fiscal Year: 2011..These studies (and our proposed studies) have made good use of the caveolin- 1 scaffolding domain (CSD) peptide which, when synthesized as a fusion peptide with the Antennapedia internalization sequence, enters cells ..
- Genetic Risk Factors for Visceral LeishmaniasisMary E Wilson; Fiscal Year: 2013..Aims of this RO1 are: 1. To test the hypothesis that candidate genes (SLC11A1, IL4-LECT2/TGFBI, HLA) determine susceptibility to cVL and to asymptomatic infection (DTH+) using dense tag-SNPs, with sample sizes ..
- Mark B Ratcliffe; Fiscal Year: 2016..on akinetic infarcts), passive constraint device procedures such as the Acorn CorCapTM Cardiac Support Device (CSD), and cell transplantation are currently being performed...
- ROLE OF CENTRAL AND PERIPHERAL SEROTONIN IN MIGRAINE PATHOPHYSIOLOGYYuqing Cao; Fiscal Year: 2012..we will investigate whether the Lmx1bf/f/p mice exhibit increased susceptibility to cortical spreading depression (CSD) - a stimulus that mimic migraine trigger...
- Transcription antitermination by OB-fold family proteinsSangita Phadtare; Fiscal Year: 2010..The CspA family proteins consist of a Cold Shock Domain (CSD), which belongs to the OB (oligomer binding) fold, a superfamily that also includes S1 domain-containing proteins...
- Regulation of Gene Expression by microRNAs in C. elegansJohn Kim; Fiscal Year: 2013..a conserved member of miRISC, as well as three highly conserved RNA binding proteins with Cold Shock Domains (CSD). We hypothesize that the CSD proteins function as key factors for repressing the expression of microRNA targets...
- Anna Kalinchuk; Fiscal Year: 2016..Our PD show that iNOS blocking reverses SD-induced effects. SA4. To investigate whether chronic SD (CSD) triggers iNOS NO AD cascade in the BF and PFC/FC...
- KEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2016..We have identified changes in brain sensory responses after cortical spreading depression (CSD), a wave of brain activity that is thought to underlie the migraine aura...
- John Novembre; Fiscal Year: 2016..Finally, we will derive a novel form of the conditional sampling distribution (CSD) for a haplotype...
- Raju Metherate; Fiscal Year: 2016..determine how activation of nAChRs alters spectral integration in A1, using tone-evoked current- source density (CSD) profiles to determine frequency RFs...
- MATTHEW WAYNE VANBROCKLIN; Fiscal Year: 2016..However, there are distinct subtypes of melanoma including chronic sun damaged (CSD), acral, and mucosal that rarely harbor BRAF mutations...
- Olfaction in the Psychosis Prodrome: Behavioral and ERP MeasuresR JURGEN KAYSER; Fiscal Year: 2010..Current source density (CSD;surface Laplacian) and temporal principal components analysis (PCA) are combined to yield reference-free measures ..
- Margaret A Rogers; Fiscal Year: 2016..symposia designed to stimulate and guide research on emerging topics in communication sciences and disorders (CSD). The American Speech-Language- Hearing Association (ASHA) has successfully coordinated 16 symposia since 1991...
- Physiological regulation of vascular function by mutant caveolin-1JOHN HENDRICK CHIDLOW; Fiscal Year: 2012..and have dissociated the inhibitory binding of Cav-1 to eNOS using mutagenesis of the caveolin scaffolding domain (CSD)...
- TGFBI and tumorigenesisXiao Fan Wang; Fiscal Year: 2010The primary objective of this proposal is to validate TGFBI (TGF-beta-induced gene, also termed as beta-igh3) as a critical biomarker for cancer diagnosis and prognosis...
- Dan Levy; Fiscal Year: 2016..Over the past two decades, evidence has gradually accumulated in support of the cortical spreading depression (CSD) theory of migraine, which proposes that CSD is the physiological event that underlies the visual aura that ..
- Translational Research in Communication Sciences &DisordersCharles R Larson; Fiscal Year: 2013..Pre-doctoral trainees will be recruited nationally, from the CSD Department, and the Northwestern University Interdepartmental Neuroscience Program...
- MIGRAINE DRUG PROPHYLAXISMichael Moskowitz; Fiscal Year: 2007..that chronic daily administration of each drug suppressed the susceptibility to cortical spreading depression (CSD), a poorly understood, slowly propagating electrophysiological event...
- TRIGGERING MECHANISMS FOR MIGRANINE HEADACHEMOSKOWITZ MICHAEL; Fiscal Year: 2006..We recently demonstrated that cortical spreading depression (CSD) an intrinsic brain parencymal event underlying migraine visual aura initiates a cascade of events in the overlying ..
- Margaret A Rogers; Fiscal Year: 2016..To develop, grow and maintain this base, the field of communication sciences and disorders (CSD) - not unlike related disciplines - must continue to develop scholars who can support its mission of advancing the ..
- KEVIN CHRISTOPHER BRENNAN; Fiscal Year: 2014..multi-animal platform to increase the throughput and data-richness of the cortical spreading depression (CSD) model in vivo...
- FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAYIgor Kratskin; Fiscal Year: 2003..high gene expression of the rate-limiting enzyme of taurine biosynthesis, cysteine sulfinic acid decarboxylase (CSD)...
- INFORMATION PROCESSING DEFICITS IN SCHIZOTYPAL PATIENTSKristin Cadenhead; Fiscal Year: 1999..measures of visual information processing, including visual backward masking (VBM) and critical stimulus duration (CSD)...
- Alveolar Bone Regeneration by Transcriptional ControlJeffrey Hollinger; Fiscal Year: 2006..Will the optimized p.Osx/HA_L assessed in vitro promote bone formation in a critical-sized defect (CSD)? We reason a non-dental CSD model is less stringent than the periodontal model...
- MOLECULAR STUDIES OF THE THIEL-BEHNKE CORNEAL DYSTROPHYRichard Yee; Fiscal Year: 2006..Beta-ig-h3, the causative gene for Reis-Bucklers' corneal dystrophy (CDB1), and the yet to be identified causative gene for ThieI-Behnke (CDB2) may play a crucial role in corneal ..
- Mechanisms of seizure propagation in limbic cortexLEWIS HABERLY; Fiscal Year: 2007..3) Based on our findings from current source-density (CSD) analysis and transmembrane potential recordings in vivo, we propose that ephaptic-field transmission plays a ..
- Global Solutions in Research and Clinical Practice in Communication Sciences andLEMMIETTA MCNEILLY; Fiscal Year: 2009..and (2) foster continuity of interactions among scientists and clinicians in communication sciences and disorders (CSD) and related disciplines from different regions of the globe...
- PERSPECTIVES ON PRODUCTIVE AGINGNancy Morrow Howell; Fiscal Year: 1999..Louis, MO. The Center for Social Development (CSD) at the George Warren Brown School of Social Work will host this event...
- Olfaction and Emotion in Depression: Behavioral Electrodermal and ERP MeasuresR Kayser; Fiscal Year: 2009..Current source density (CSD;surface Laplacian) and temporal principal components analysis (PCA) are combined to yield reference-free measures ..
- EARLY VISUAL PROCESSING IN SCHIZOPHRENIAMichael Green; Fiscal Year: 1992..tests (Continuous Performance Test (CPT), Span of Apprehension, Backward Masking, and Critical Stimulus Duration (CSD) can be explained by a common deficit in early visual processing...
- ERP CORRELATES OF NORMAL AND ABNORMAL MEMORYDavid Friedman; Fiscal Year: 2000..Finally, the use of current source density (CSD) analysis and brain electric source analysis (BESA) for estimating the spatial configuration of brain generators ..
- Caveolin-1/lGF-IR Interactions in OligodendrocytesDaniel Mikol; Fiscal Year: 2004..By binding to signaling proteins via a region termed the caveolinscaffolding domain (CSD), caveolin-1 regulates (generally inhibits) signal transduction...
- FUNCTIONAL NEAR INFRARED IMAGING SYSTEMBENIAMINO BARBIERI; Fiscal Year: 2002..domain multiple distance method, continuous wave differential path length method, and crossed source-detector (CSD) path method...
- ANIMAL MODEL TO STUDY THE ROLE OF CYTOTOXICITY IN GVHDRobert Levy; Fiscal Year: 2004..Single (i.e., perforin or CD95L = csd) and double cytotoxic deficient (cdd) strains will be employed to assess the role of donor cytotoxic function in ..
- NMDA RECEPTORS IN PROCESSING CONTINGENT AEP GENERATIONDaniel Javitt; Fiscal Year: 1991..The laminar profile of activity will be analyzed using one-dimensional current source density (CSD) techniques which provides an index of the magnitude, location and duration of intralaminar transmembrane current ..
- Treatment of BIGH3-related Corneal Dystrophies with MeptidesChing Yuan; Fiscal Year: 2008unreadable] DESCRIPTION: BIGH3-related corneal dystrophies are a group of potentially blinding inherited corneal disorders that have been attributed to more than 30 missense mutations of BIGH3 gene in 5q3l of humans...
- CEREBRAL ISCHEMIA DURING ANESTHESIA AND SURGERYPiyush Patel; Fiscal Year: 2000..In the third phase, the effect of anesthetics on cortical spreading depression (CSD) will be determined.
- CGRP Regulation of iNOS and MAP Kinases/Phosphatases in Trigeminal Ganglia GliaPaul L Durham; Fiscal Year: 2010....
- VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSIONDavid Busija; Fiscal Year: 2001Cortical spreading depression (CSD) is a wave of depolarization that results in complex changes in pial arteriolar diameter, intense vasodilation lasting approximately 2 minutes, a return of diameter to baseline for several minutes, and ..
- Cerebrovascular Dysfunction in Insulin ResistanceDavid Busija; Fiscal Year: 2004..We believe that our studies will result in new and important findings that will lead to improved therapies to reduce morbidity and mortality in IR individuals. ..
- BIOCHEMISTRY OF UTERINE HEPARAN SULFATE RECEPTORSDaniel Carson; Fiscal Year: 2006..In addition, we will examine the role(s) that HIP/L29 plays in vivo using transgenic mouse models. ..
- Functional measure of 3rd trimester FASD: neonatal sheepTIMOTHY CUDD; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Modified Late Infarct Reperfusion to Prevent Post MI CHFRobert Gorman; Fiscal Year: 2006..unreadable] [unreadable]..
- THE MUTAGENICITY OF MINERAL FIBERSTOM HEI; Fiscal Year: 2006..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
- Mast Cells: Role in the Pathophysiology of HeadacheDan Levy; Fiscal Year: 2007..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. [unreadable] [unreadable] [unreadable]..
- Electrophysiology Of Avian Brainstem TopographyDavid Harris; Fiscal Year: 2007..space-time maps of multi-unit activity and the timing and distribution of current sources and sinks are defined with maps of field potentials, processed with current source density (CSD) analysis. [unreadable] [unreadable] [unreadable]
- Neurophysiological Basis of fMRICharles Schroeder; Fiscal Year: 2007..and depth recordings with linear array multielectrodes, and will focus on ERP and current source density (CSD) measures as well as action potentials...
- HMG1 SIGNALING IN INFLAMMATION FOLLOWING BRAIN ISCHEMIAMichael Moskowitz; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..