TERT

Summary

Gene Symbol: TERT
Description: telomerase reverse transcriptase
Alias: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase-associated protein 2
Species: human

Top Publications

  1. ncbi Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1757-68. 2006
  2. doi TERT promoter mutations in familial and sporadic melanoma
    Susanne Horn
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Science 339:959-61. 2013
  3. pmc Highly recurrent TERT promoter mutations in human melanoma
    Franklin W Huang
    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Science 339:957-9. 2013
  4. pmc TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    Patrick J Killela
    Pediatric Brain Tumor Foundation Institute at Duke, and Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:6021-6. 2013
  5. pmc Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
  6. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
  7. ncbi Protein composition of catalytically active human telomerase from immortal cells
    Scott B Cohen
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead NSW 2145, Australia
    Science 315:1850-3. 2007
  8. pmc Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
    Clare Turnbull
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:604-7. 2010
  9. pmc A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Nat Genet 43:1210-4. 2011
  10. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009

Research Grants

  1. Monica Bessler; Fiscal Year: 2014
  2. Michael D Stone; Fiscal Year: 2016
  3. Juli Feigon; Fiscal Year: 2016
  4. CARRIE ANN JESSICA OLIVIA GORDON; Fiscal Year: 2014
  5. TELOMERE REPLICATION AND SENESCENCE IN YEAST
    Victoria Lundblad; Fiscal Year: 2012
  6. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
  7. Steven E Artandi; Fiscal Year: 2014
  8. William C Hahn; Fiscal Year: 2014
  9. Dean T Yamaguchi; Fiscal Year: 2016
  10. Jennifer Anne Doherty; Fiscal Year: 2014

Patents

  1. Human telomerase catalytic subunit

Detail Information

Publications427 found, 100 shown here

  1. ncbi Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1757-68. 2006
    ....
  2. doi TERT promoter mutations in familial and sporadic melanoma
    Susanne Horn
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Science 339:959-61. 2013
    ..sequencing and identified a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomerase...
  3. pmc Highly recurrent TERT promoter mutations in human melanoma
    Franklin W Huang
    Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Science 339:957-9. 2013
    ..Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 ..
  4. pmc TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    Patrick J Killela
    Pediatric Brain Tumor Foundation Institute at Duke, and Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:6021-6. 2013
    ..telomerase (alternative lengthening of telomeres), and point mutations in the promoter of the telomerase reverse transcriptase (TERT) gene increase telomerase expression and have been shown to occur in melanomas and a small ..
  5. pmc Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    ..We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7...
  6. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  7. ncbi Protein composition of catalytically active human telomerase from immortal cells
    Scott B Cohen
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead NSW 2145, Australia
    Science 315:1850-3. 2007
    ..Mass spectrometric sequencing of the protein components and molecular size determination indicated an enzyme composition of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin.
  8. pmc Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
    Clare Turnbull
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:604-7. 2010
    ..We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1...
  9. pmc A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, USA
    Nat Genet 43:1210-4. 2011
    ..We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10))...
  10. pmc New common variants affecting susceptibility to basal cell carcinoma
    Simon N Stacey
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:909-14. 2009
    ..Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.
  11. doi The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Working Environment, National Institute of Occupational Health, N 0033, Oslo, Norway
    Carcinogenesis 30:1368-71. 2009
    Genome-wide association studies have provided evidence that common variation at 5p15.33 [telomerase reverse transcriptase (TERT)-cleft lip and palate transmembrane 1-like (CLPTM1L)], 6p21.33 and 15q25...
  12. pmc A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    Gloria M Petersen
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Nat Genet 42:224-8. 2010
    ..71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers...
  13. pmc TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends
    Franklin L Zhong
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 150:481-94. 2012
    ..of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT...
  14. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
    Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres.
  15. ncbi Reverse transcriptase motifs in the catalytic subunit of telomerase
    J Lingner
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 276:561-7. 1997
    ..A yeast (Saccharomyces cerevisiae) homolog was found and subsequently identified as EST2 (ever shorter telomeres), deletion of which had independently been shown to produce telomere defects...
  16. ncbi TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
    Huawei Xin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:559-62. 2007
    ....
  17. doi Frequency of TERT promoter mutations in human cancers
    João Vinagre
    Institute of Molecular Pathology and Immunology of the University of Porto, 4200 465 Porto, Portugal
    Nat Commun 4:2185. 2013
    ..Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and ..
  18. doi Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
    Judith Haendeler
    Molecular Cardiology, Department of Internal Medicine III, Centre of Biological Chemistry, University of Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 29:929-35. 2009
    The enzyme telomerase and its catalytic subunit the telomerase reverse transcriptase (TERT) are important for maintenance of telomere length in the nucleus. Recent studies provided evidence for a mitochondrial localization of TERT...
  19. pmc High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    Jean Charles Nault
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, Paris F 75010, France
    Nat Commun 4:2218. 2013
    ....
  20. doi Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma
    X F Chen
    Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China
    Genet Mol Res 11:370-8. 2012
    ..b>TERT rs2736100 and CLPTM1L rs401681 and rs402710 were genotyped using the ABI TaqMan Allelic Discrimination assay...
  21. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
    ..TERT encodes telomerase reverse transcriptase, which together with the RNA component of telomerase (TERC), is required to maintain telomere ..
  22. doi Variation at the TERT locus and predisposition for cancer
    Duncan M Baird
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Expert Rev Mol Med 12:e16. 2010
    ..Here I review the evidence that variation at the 5p15.33 locus, which contains the TERT gene (encoding the catalytic subunit of telomerase), might play a role in the determination of cancer risk...
  23. doi Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells
    Z Liu
    Department of Microbiology Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine and Second Hospital, Shandong University, Jinan, PR China
    Oncogene 32:4203-13. 2013
    Telomerase activation through induction of telomerase reverse transcriptase (hTERT) contributes to malignant transformation by stabilizing telomeres...
  24. pmc Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
    Zsofia Kote-Jarai
    The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 43:785-91. 2011
    ..0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported...
  25. doi Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
    Hideyuki Arita
    Department of Neurosurgery and Neuro Oncology, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Acta Neuropathol 126:267-76. 2013
    ..In this study, we investigated the presence of mutations in the promoter of the telomerase reverse transcriptase (TERT) gene in a series of 546 gliomas...
  26. pmc Highly prevalent TERT promoter mutations in aggressive thyroid cancers
    Xiaoli Liu
    Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21287, USA
    Endocr Relat Cancer 20:603-10. 2013
    ..corresponding to -124 C>T and -146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet...
  27. doi Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome
    Yves Allory
    Epithelial Carcinogenesis Group, Molecular Pathology Program, CNIO Spanish National Cancer Research Center, Madrid, Spain Université Paris Est Créteil, Institut Mondor de Recherche Biomedicale, Creteil, France
    Eur Urol 65:360-6. 2014
    Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression.
  28. pmc TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
    Marc Remke
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 126:917-29. 2013
    b>Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma...
  29. pmc Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers
    Jonathan Beesley
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 6:e24987. 2011
    Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC)...
  30. ncbi Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Natinoal Institutes of Health, 111, Alexander Drive, MD D3 01, Research Triangle Park, NC 27709, USA
    Aging Cell 3:399-411. 2004
    ..Here we show that human telomerase reverse transcriptase (hTERT) is targeted to the mitochondria by an N-terminal leader sequence, and that mitochondrial ..
  31. ncbi Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
    Kei Haga
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoku 104 0045, Tokyo, Japan
    Cancer Sci 98:147-54. 2007
    ..Subsequent introduction of hTERT, the telomerase catalytic subunit, into cells with low p16(INK4a) levels resulted in efficient immortalization of three cell types ..
  32. ncbi Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
    Leslie G Wooten-Blanks
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    FASEB J 21:3386-97. 2007
    ....
  33. pmc A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
    Andrew S Venteicher
    Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA
    Science 323:644-8. 2009
    ..Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin...
  34. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR]=1...
  35. doi Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
    Katrin Hoffmeyer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    Science 336:1549-54. 2012
    ..Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert. β-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an ..
  36. ncbi Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor
    Basem S Goueli
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:8042-7. 2003
    Upregulation of human telomerase reverse transcriptase (hTERT) transcription accounts for the immortalization of greater than 85% of all human tumor cells. However, the mechanism whereby hTERT expression is activated remains unresolved...
  37. ncbi Telomerase mutations in families with idiopathic pulmonary fibrosis
    Mary Y Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    N Engl J Med 356:1317-26. 2007
    ..Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary ..
  38. pmc Telomere length and genetic analyses in population-based studies of endometrial cancer risk
    Jennifer Prescott
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer 116:4275-82. 2010
    ..When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic...
  39. ncbi Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts
    G A Ulaner
    Veterans Affairs Palo Alto Health Care System, and Department of Medicine, Stanford University, California 94304, USA
    Cancer Res 58:4168-72. 1998
    ..we examined telomerase activity and the expression of the human telomerase RNA subunit and the human telomerase reverse transcriptase protein (hTERT) during human fetal heart, liver, and kidney development...
  40. ncbi Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts
    Kazuhito Naka
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu 474 8522, Japan
    J Biol Chem 279:2030-7. 2004
    ..These results suggest that the ATM-dependent signaling pathway triggered by DNA damage is dispensable for activation of p38 MAPK and SIPS in response to IR or oxidative stress...
  41. doi MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth
    Ying Yi Wang
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, China
    CNS Neurosci Ther 18:722-8. 2012
    ..However, the precise biological function and molecular mechanism of miR-21 in GBM remain elusive. This study is designed to explore the mechanism of miR-21 involved in the control of GBM cell growth...
  42. doi TERT promoter mutations in primary and secondary glioblastomas
    Naosuke Nonoguchi
    Section of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon, France
    Acta Neuropathol 126:931-7. 2013
    b>Telomerase reverse transcriptase (TERT) is up-regulated in a variety of human neoplasms...
  43. pmc TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism
    P Sivaramakrishna Rachakonda
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 110:17426-31. 2013
    The telomerase reverse transcriptase (TERT) promoter, an important element of telomerase expression, has emerged as a target of cancer-specific mutations...
  44. ncbi Extension of life-span by introduction of telomerase into normal human cells
    A G Bodnar
    Geron Corporation, Menlo Park, CA 94025, USA
    Science 279:349-52. 1998
    ..pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomerase catalytic subunit. In contrast to telomerase-negative control clones, which exhibited telomere shortening and senescence, ..
  45. pmc Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes
    Liliana Terrin
    Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico IRCCS, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano PN, Italy
    J Virol 82:10175-87. 2008
    ....
  46. pmc Telomerase modulates Wnt signalling by association with target gene chromatin
    Jae Il Park
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 460:66-72. 2009
    ..The telomerase protein component TERT (telomerase reverse transcriptase) interacts with BRG1 (also called SMARCA4), a SWI/SNF-related chromatin remodelling protein, and ..
  47. doi hTERT cancer risk genotypes are associated with telomere length
    Beatrice S Melin
    Department of Radiation Sciences, Oncology, Umea University, Sweden
    Genet Epidemiol 36:368-72. 2012
    ..Recently, single nucleotide polymorphisms in the region of the human telomerase reverse transcriptase (hTERT) gene were associated with various malignancies, including glioma, lung and urinary bladder ..
  48. pmc Many disease-associated variants of hTERT retain high telomerase enzymatic activity
    Arthur J Zaug
    Department of Chemistry and Biochemistry, University of Colorado Biofrontiers Institute, Boulder, CO 80309 0596, USA, Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309 0596, USA and Department of Chemistry and Biochemistry, DePauw University, Greencastle, IN 46135, USA
    Nucleic Acids Res 41:8969-78. 2013
    Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer...
  49. pmc TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine
    Isaac Kinde
    Authors Affiliations The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center Departments of Pathology, Oncology, and Urology, The Johns Hopkins Medical Institutes, Baltimore, Maryland
    Cancer Res 73:7162-7. 2013
    Activating mutations occur in the promoter of the telomerase reverse transcriptase (TERT) gene in 66% of muscle-invasive urothelial carcinomas...
  50. pmc Constitutional telomerase mutations are genetic risk factors for cirrhosis
    Rodrigo T Calado
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Hepatology 53:1600-7. 2011
    ..University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic ..
  51. pmc High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis
    Angela Ying Jian Li
    Department of Molecular Pharmacology, City of Hope Beckman Research Institute, Duarte, CA 91010 3000, USA
    Mol Cell Biol 31:2605-17. 2011
    ..Our study reveals a novel link between HMGA2 and the regulation of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, which offers critical insight into how HMGA2 ..
  52. pmc Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk
    Tun Hsiang Yang
    Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA 02215, USA
    BMC Med Genomics 4:63. 2011
    ..The purpose of this paper is to present an improved approach to biomarker identification...
  53. pmc The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    L M Colgin
    Children s Medical Research Institute, Westmead, New South Wales, Australia
    Neoplasia 2:426-32. 2000
    The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes...
  54. doi hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells
    Inthrani R Indran
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cancer Res 71:266-76. 2011
    The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase holoenzyme. Evidence is accumulating to link hTERT to activities other than telomere maintenance and immortalization...
  55. pmc A novel prodrug of epigallocatechin-3-gallate: differential epigenetic hTERT repression in human breast cancer cells
    Syed M Meeran
    Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall 175, Birmingham, AL 35294 1170, USA
    Cancer Prev Res (Phila) 4:1243-54. 2011
    ..Furthermore, both EGCG and pro-EGCG inhibited the transcription of hTERT (human telomerase reverse transcriptase), the catalytic subunit of telomerase, through epigenetic mechanisms in estrogen receptor (ER)-..
  56. pmc Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations
    Alberto Diaz de Leon
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e10680. 2010
    ..Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF)...
  57. pmc Telomerase recruitment requires both TCAB1 and Cajal bodies independently
    J Lewis Stern
    Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
    Mol Cell Biol 32:2384-95. 2012
    ..Our results demonstrate that telomerase has multiple independent requirements for recruitment to telomeres and that the function of TCAB1 is to directly transport telomerase to telomeres...
  58. pmc Specificity requirements for human telomere protein interaction with telomerase holoenzyme
    Alec N Sexton
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    J Biol Chem 287:34455-64. 2012
    ..maintained by the enzyme telomerase, which uses a template within its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to accomplish the synthesis of single-stranded DNA repeats...
  59. ncbi Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
    I Horikawa
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 59:826-30. 1999
    ..Regulation of expression of the catalytic subunit, human telomerase reverse transcriptase (hTERT), is suggested as the major determinant of the enzymatic activity...
  60. ncbi Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
    Vera Gorbunova
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:38540-9. 2002
    ..We hypothesize that healing of DNA breaks by telomerase inhibits the induction of cell death, but because healing does not provide legitimate DNA repair, it does not protect cells from SIPS...
  61. ncbi Regulation of telomerase by telomeric proteins
    Agata Smogorzewska
    The Rockefeller University, New York, New York 10021, USA
    Annu Rev Biochem 73:177-208. 2004
    ..sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast), and accessory factors (the Est1 proteins and ..
  62. doi Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population
    Guangfu Jin
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, China
    Carcinogenesis 30:987-90. 2009
    Chromosome 5p15.33, containing TERT and CLPTM1L genes, was recently identified as one of the susceptible regions for lung cancer in Caucasian populations...
  63. pmc Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
    Rodrigo T Calado
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:1187-92. 2009
    ..bone marrow samples from 133 consecutive patients with acute myeloid leukemia and 198 controls for variations in TERT and TERC genes...
  64. ncbi Telomerase catalytic subunit homologs from fission yeast and human
    T M Nakamura
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 277:955-9. 1997
    ..Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases...
  65. ncbi Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
    C M Counter
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Oncogene 16:1217-22. 1998
    ..In humans, mRNA expression of hTERT (hEST2), the candidate telomerase catalytic subunit gene, appears to parallel the levels of telomerase enzyme activity, suggesting that induction of hTERT ..
  66. ncbi hTERT associates with human telomeres and enhances genomic stability and DNA repair
    Girdhar G Sharma
    Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
    Oncogene 22:131-46. 2003
    ..The effect on DNA repair is likely indirect as TERT does not directly affect DNA end rejoining in vitro or meiotic recombination in vivo...
  67. pmc Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
    Thorunn Rafnar
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 41:221-7. 2009
    ..However, neither variant could fully account for the association of the other. rs2736098 corresponds to A305A in the telomerase reverse transcriptase (TERT) protein and rs401681 is in an intron of the CLPTM1L gene.
  68. ncbi hTERT antagonizes p53-induced apoptosis independently of telomerase activity
    Rubaiyat Rahman
    Department of Oncology Pathology, Cancer Center Karolinska, R8 04, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Oncogene 24:1320-7. 2005
    ..Previously, we found that the human telomerase reverse transcriptase (hTERT) gene is downregulated by p53...
  69. pmc Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells
    Emma J Chapman
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds LS97TF, United Kingdom
    Mol Cancer Res 6:1154-68. 2008
    ..b>TERT-NHUC showed overexpression of the polycomb repressor complex (PRC1 and PRC4) components, BMI1 and SIRT1, and down-..
  70. ncbi The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter
    Y S Cong
    Cancer Research Group, Department of Pathology and Molecular Medicine, McMaster University HSC 4H30, 120 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Hum Mol Genet 8:137-42. 1999
    ..The abundance of these sites suggests the possibility that hTERT expression may be subject to multiple levels of control and be regulated by different factors in different cellular contexts...
  71. pmc An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
    Yoshiko Maida
    Cancer Stem Cell Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Nature 461:230-5. 2009
    ..However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate ..
  72. doi A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
    Olga A Kovalenko
    Department of Pharmacology and Physiology, National Institute of Environmental and Health Sciences, 111 TW Alexander Dr, MD F0 02, Durham, NC 27709, USA
    Aging Cell 9:203-19. 2010
    ....
  73. pmc Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways
    R T Sitaram
    Department of Medical Biosciences and Pathology, Umea University, Umea, Sweden
    Br J Cancer 103:1255-62. 2010
    ..Wilms' tumour 1 (WT1) gene was discovered as a tumour suppressor gene. Later findings have suggested that WT1 also can be oncogenic. This complexity is partly explained by the fact that WT1 has a number of target genes...
  74. pmc Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
    Toshihiro Matsuo
    Department of Orthopaedic Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center 3 1, Aoyamacho, Kure, Hiroshima, 7370023 Japan
    J Exp Clin Cancer Res 31:5. 2012
    One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progression in several sarcomas...
  75. doi Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population
    Rong Zhong
    Department of Epidemiology and Biostatistics and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Carcinog 52:E118-26. 2013
    Recent genome-wide association studies (GWAS) have reported multiple genetic variations at 5p15.33 (TERT-CLPTM1L) associated with risk of lung cancer...
  76. doi Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma
    Glynis A Scott
    1 Department of Dermatology, University of Rochester School of Medicine, Rochester, NY, USA 2 Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine, Rochester, NY, USA
    Mod Pathol 27:516-23. 2014
    ..report the identification of a set of recurrent mutations in melanoma in the promoter of the telomerase reverse transcriptase gene (TERT) that appears to be the result of mutagenesis from ultraviolet (UV) radiation...
  77. ncbi Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells
    Jaejoon Won
    National Creative Research Initiative Center for Genetic Reprogramming, Institute for Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
    FASEB J 16:1943-5. 2002
    ..Telomerase activity is tightly regulated by the expression of its catalytic subunit human telomerase reverse transcriptase (hTERT)...
  78. ncbi On the road to immortality: hTERT upregulation in cancer cells
    Ralf Janknecht
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    FEBS Lett 564:9-13. 2004
    ..due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase)...
  79. ncbi Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression
    Stephane Roche
    Centre d investigation Biologique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    J Cell Biochem 101:271-80. 2007
    ..Oct-4, Rex-1, and TERT genes are well-known for the maintenance of pluripotentiality differentiation and the proliferative capacity of ..
  80. ncbi TAK1 represses transcription of the human telomerase reverse transcriptase gene
    T Fujiki
    Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Oncogene 26:5258-66. 2007
    ..activity is tightly regulated by the expression of its catalytic subunit, namely, the human telomerase reverse transcriptase (hTERT)...
  81. doi A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis
    T Mushiroda
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Med Genet 45:654-6. 2008
    ..replication sample set (83 cases and 535 controls) and found a significant association of an SNP in intron 2 of the TERT gene (rs2736100), which encodes a reverse transcriptase that is a component of a telomerase, with IPF; a ..
  82. ncbi Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis
    Ferenc Sipos
    and Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Scand J Gastroenterol 43:289-98. 2008
    ..We assayed the expression alterations of regenerative signal receptors and cell-aging inhibitory systems within colonic crypts by considering the histological activity of the disease...
  83. pmc Chromosome end maintenance by telomerase
    Jennifer L Osterhage
    Department of Biology, Hanover College, Hanover, Indiana 47243, USA
    J Biol Chem 284:16061-5. 2009
    ..This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease...
  84. pmc TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
    Eladio Abreu
    Department of Biochemistry, University of Georgia, Athens, Georgia 30602, USA
    Mol Cell Biol 30:2971-82. 2010
    ....
  85. pmc Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions
    Yong Zhao
    Department of Cell Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 42:297-307. 2011
    ..Overexpressed telomerase is also less processive than the endogenously expressed telomerase. These findings reveal two major distinct extension modes adopted by telomerase in vivo...
  86. doi Knockdown of hTERT alters biophysical properties of K562 cells resulting in decreased migration rate in vitro
    Yingyu Zhang
    Hemorheology Center, Peking University Health Science Center, Beijing 100191, People s Republic of China
    Cell Biochem Biophys 61:595-603. 2011
    ..leukemia cells, we transfected K562, a human erythroleukemia cell line with an antisense-hTERT (human telomerase reverse transcriptase) cDNA vector, and examined the biological and biophysical properties of the stably transfected cells (..
  87. pmc Involvement of telomerase reverse transcriptase in heterochromatin maintenance
    Yoshiko Maida
    Division of Cancer Stem Cell, National Cancer Center Research Institute, Tokyo, Japan
    Mol Cell Biol 34:1576-93. 2014
    ..In association with the telomerase RNA component (TERC), the telomerase reverse transcriptase (TERT) forms telomerase and counteracts telomere attrition, and without TERC, TERT has been ..
  88. doi Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
    Lili Zhou
    Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China
    Biochem Biophys Res Commun 386:739-43. 2009
    ..These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer...
  89. doi hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells
    Vassilis Papanikolaou
    Department of Biology, Faculty of Medicine, University of Thessaly, Larissa, Greece
    Int J Radiat Biol 87:609-21. 2011
    ..In the present study, we investigated the expression of human telomerase reverse transcriptase (hTERT) and TA and their regulation, as well as apoptotic rates and correlation with the presence of ..
  90. pmc Telomerase can act as a template- and RNA-independent terminal transferase
    Neal F Lue
    Department of Microbiology and Immunology, W R Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:9778-83. 2005
    ..The terminal transferase activity of telomerase may account for some of the hitherto unexplained effects of telomerase overexpression on cell physiology...
  91. doi Polymorphisms in telomere maintenance genes and risk of lung cancer
    Jin Eun Choi
    Department of Biochemistry, Kyungpook National University Hospital, Samduk 2a 50, Daegu, 700 412, Korea
    Cancer Epidemiol Biomarkers Prev 18:2773-81. 2009
    ..was conducted to comprehensively evaluate the associations between polymorphisms in telomere maintenance genes (TERT, TRF1, TNKS1, TRF2, RAP1, and POT1) and lung cancer risk...
  92. pmc MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    Shivani Ponnala
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Cell Signal 23:2065-75. 2011
    ..Taken together, these data provide new insights into the mechanisms underlying MMP-9-mediated hTERT expression in glioma proliferation...
  93. pmc Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase
    Huira C Kopera
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5618, USA
    Proc Natl Acad Sci U S A 108:20345-50. 2011
    ..Finally, we demonstrate that ORF1p is not strictly required for ENi retrotransposition at dysfunctional telomeres. Thus, these data further highlight similarities between the mechanism of ENi L1 retrotransposition and telomerase...
  94. ncbi hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    M Meyerson
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:785-95. 1997
    ..We report the cloning of a human gene, hEST2, that shares significant sequence similarity with the telomerase catalytic subunit genes of lower eukaryotes...
  95. ncbi Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    M Wick
    Bayer AG, Central Research Division, Department of Molecular Biology, D 51368, Leverkusen, Germany
    Gene 232:97-106. 1999
    ..Recent data suggest that expression of the human telomerase reverse transcriptase subunit (hTERT) represents the limiting factor for telomerase activity...
  96. ncbi hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer
    Luo Wang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 8:2883-9. 2002
    ..The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase catalytic subunit (hTERT) as a prognostic marker...
  97. pmc No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk
    Karen A Pooley
    Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, 2 Worts Causeway, Cambridge CB18RN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1862-5. 2010
    A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers.
  98. pmc Pancreatic cancer susceptibility loci and their role in survival
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e27921. 2011
    ..Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with ..
  99. ncbi Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 24:1627-32. 2006
    ..We investigated whether hTERT MNS16A variant genotype predicted survival in GBM patients...
  100. doi Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers
    Yufei Wang
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Carcinogenesis 31:234-8. 2010
    Genome-wide association studies have provided evidence that common variation at 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk...
  101. doi A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Ministry of Education MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
    Nat Genet 43:792-6. 2011
    ..0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1...

Research Grants63

  1. Monica Bessler; Fiscal Year: 2014
    ..investigated the frequency, heritability, penetrance, and expressivity of mutations in TERC and in the telomerase catalytic subunit TERT in patients diagnosed with BMF and their families...
  2. Michael D Stone; Fiscal Year: 2016
    ..catalytic mechanism that requires a strong functional interdependence of the telomerase RNA, telomerase reverse transcriptase (TERT), and several additional protein subunits...
  3. Juli Feigon; Fiscal Year: 2016
    ..telomerases contain a large RNA (TR) (451 nt in humans) that includes an RNA template and a unique telomerase reverse transcriptase (TERT), as well as other proteins important for function in vivo...
  4. CARRIE ANN JESSICA OLIVIA GORDON; Fiscal Year: 2014
    ..Recently published reports have identified ROS as a regulator of TERT, the catalytic subunit of telomerase, which uses its enzymatic activity to maintain telomere length...
  5. TELOMERE REPLICATION AND SENESCENCE IN YEAST
    Victoria Lundblad; Fiscal Year: 2012
    ..Past work in our laboratory has identified three proteins, Estl, Est2 and Est3, that are subunits of yeast telomerase...
  6. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    ..Telomerase is a ribonucleoprotein complex with its core constituents being telomerase reverse transcriptase (TERT) and telomerase RNA (TR)...
  7. Steven E Artandi; Fiscal Year: 2014
    ..complex, only three components of the telomerase holoenzyme were identified until recently: TERT, the telomerase reverse transcriptase, TERC, the telomerase RNA component, and dyskerin, a TERC-binding protein...
  8. William C Hahn; Fiscal Year: 2014
    ..Moreover, mutations of telomerase components required for catalytic activity, TERT and TERC, are found in diseases characterized by stem cell failure including dyskeratosis congenita, subsets of ..
  9. Dean T Yamaguchi; Fiscal Year: 2016
    ..Experiments will be done in human MSCs (hMSCs) that have been transduced to express human telomerase reverse transcriptase (TERT) to enhance their longevity in vitro...
  10. Jennifer Anne Doherty; Fiscal Year: 2014
    ..Recently, several large-scale genome-wide association studies have reported that SNPs in the telomerase reverse transcriptase (TERT) gene are strongly associated with lung cancer risk...
  11. Helen M Blau; Fiscal Year: 2016
    ..The enzyme telomerase extends telomeres, and the limiting component of telomerase in most cells is telomerase reverse transcriptase (TERT)...
  12. ADAM ROBERT BROWN; Fiscal Year: 2014
    ..from adenomas and uninvolved mucosa and expression levels of KLF9, TR[unreadable]1, FASN, and telomerase reverse transcriptase (TERT) will be evaluated by Western blot and qPCR...
  13. THOMAS ROBERT CECH; Fiscal Year: 2016
    ..In addition, G100 on the surface of TERT is necessary for functional interaction with POT1-TPP1, and additional amino acid determinants will be identified...
  14. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2012
    ..In humans, but not mice, activation of telomerase reverse transcriptase (TERT) is also observed in ~90% of tumors...
  15. Richard C Allsopp; Fiscal Year: 2014
    ..inducible factor 1 alpha (Hif11) as one transcription factor that, via regulation of levels of telomerase reverse transcriptase (Tert), is essential for maintenance of functional levels of telomerase and telomere reserve in ..
  16. CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS
    Lopa Mishra; Fiscal Year: 2013
    ..High levels of cell cycle regulators including CDK4, c-Myc, h-TERT, B-catenin, and the E3 ligase PRAJA occur in tumors in these animals...
  17. Kathleen Collins; Fiscal Year: 2016
    ..This RNP then recruits telomerase reverse transcriptase (TERT) to generate the active enzyme...
  18. Denise A Galloway; Fiscal Year: 2016
    ..recruitment of transcriptional activators and elimination of repressors at the hTERT promoter, and further enhances TERT levels through post-transcriptional means...
  19. RONALD ANTHONY DEPINHO; Fiscal Year: 2016
    ..The specific efforts focus on (i) the use of an inducible telomerase model (TERT-ER) to assess the regenerative impact on mitochondrial biology and degenerative phenotypes in stem cells and ..
  20. RONALD ANTHONY DEPINHO; Fiscal Year: 2014
    ..The specific efforts focus on (i) the use of an inducible telomerase model (TERT-ER) to assess the regenerative impact on mitochondrial biology and degenerative phenotypes in stem cells and ..
  21. Kathleen Collins; Fiscal Year: 2016
    ..to specialize its role in telomere maintenance, requiring the collaboration of telomerase RNA (TER), telomerase reverse transcriptase (TERT), and other subunits of a biologically active telomerase holoenzyme...
  22. Christine Kim Garcia; Fiscal Year: 2016
    ..our group, that a subset of pulmonary fibrosis is caused by mutations in the genes encoding the protein component (TERT) and the RNA component (TERC) of telomerase, a ribonucleoprotein enzyme that catalyzes the addition of hexameric ..
  23. The role of mTert-expressing stem cells in tooth formation and renewal
    DIANA LYNN CARLONE; Fiscal Year: 2013
    ..Telomerase (Tert) activity prevents cellular senescence and is required for maintenance of stem cells in regenerative tissues...
  24. Thomas A Rando; Fiscal Year: 2016
    ..to tissue aging by suppression of stem cell functionality, Telomerase and novel functions of the protein component (TERT) in regulating stem cell function and regulating Wnt signaling, and the Foxo transcription factors which regulate ..
  25. Steven E Artandi; Fiscal Year: 2015
    ..In addition to its role in telomere elongation, we have shown that TERT, the telomerase protein subunit, exerts potent effects on tissue stem cells through an auxiliary pathway...
  26. Role of the Putative Tumor Suppressor PinX1 in the Etiology of Liver Cancer
    Xiao Zhen Zhou; Fiscal Year: 2010
    ..the role of telomerase in PinX1-related liver cancer development using in vitro and in vivo models, including TERT-/- mice...
  27. DENNIS CHRISTOPHER BRUEMMER; Fiscal Year: 2015
    ..addition to its well- established function to synthesize telomere repeats at the ends of chromosomes, telomerase reverse transcriptase (TERT) serves a direct role in facilitating the activation of gene expression programs...
  28. Repression of the hTERT gene during cell differentiation
    Jiyue Zhu; Fiscal Year: 2013
    ..a condensed chromatin domain in many somatic cells, while such a domain did not exist in the less repressed mouse TERT gene...
  29. The role of Rif1p preferential elongation of short telomeres
    JEAN SUH MCGEE; Fiscal Year: 2011
    ..For aim i, a yeast strain, deleted in the telomerase catalytic subunit, will be used to shorten telomeres...
  30. Robert A Weinberg; Fiscal Year: 2016
    ....
  31. Telomerase in Inflammation and Atherosclerosis
    DENNIS CHRISTOPHER BRUEMMER; Fiscal Year: 2010
    ..Stem cells constitutively overexpress the catalytic core telomerase reverse transcriptase (TERT) manifesting high levels of telomerase activity, which confers an apparently indefinite ..
  32. Steven E Artandi; Fiscal Year: 2015
    ..specific assembly factors to produce an enzymatically active ribonucleoprotein comprising the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC) and dyskerin, a TERC-binding protein required for ..
  33. SP cells and downstream progenitors in human and mouse muscle
    Emanuela Gussoni; Fiscal Year: 2013
    ..are important for muscle development and participate in muscle regeneration in post-natal life;Aim 4: Use the m-TERT GFP model to identify telomerase-expressing cells in skeletal muscle and determine their relationship to muscle SP, ..
  34. Victoria Lundblad; Fiscal Year: 2016
    ..The genetic screen resulted in identification of two new EST genes (EST2 and EST3) as well as a novel est-like mutation in a gene previously implicated at the telomere (CDC13)...
  35. Telomerase RNA Transfected Dendritic Cell Vaccines
    Johannes Vieweg; Fiscal Year: 2005
    ..a wide range of cancer patients by inducing immunity against the protein subunit of human telomerase, telomerase reverse transcriptase (TERT)...
  36. Telomerase Specific Caspase Transfer for Gliomas
    Seiji Kondo; Fiscal Year: 2004
    ..Activation of telomerase is tightly regulated at the transcriptional level of the telomerase catalytic subunit (hTERT)...
  37. Structure of ribonucleoprotein: telomerase
    Gabriele Varani; Fiscal Year: 2007
    ..The enzymatic activity of telomerase (TERT) is homologous to viral reverse transcriptases, while the RNA (TER) provides the template and a landing dock for ..
  38. PinX1, a Putative Tumor Suppressor for Prostate Cancer
    Xiao Zhou; Fiscal Year: 2004
    ..Although the telomerase catalytic subunit hTERT is transcriptionally activated by some oncogenes, little is known about the regulation of ..
  39. CANCER VACCINATION AGAINST TELOMERASE
    Eli Gilboa; Fiscal Year: 2005
    ..The polypeptide component of telomerase, also know as telomerase reverse transcriptase or TERT, is an attractive candidate for a broadly expressed tumor antigen since telomerase is silent ..
  40. Telomerase and Telomeres: Structure, Function and Regulation
    Thomas Cech; Fiscal Year: 2009
    ..there is substantial interest in anti-telomerase chemotherapeutic agents and in TERT (telomerase reverse transcriptase) as an antigen for cancer vaccines...
  41. Ula V Jurkunas; Fiscal Year: 2016
    ..Nrf2 levels by plasmid transfection and by intracellular Nrf2 stabilizers, such 3H-1,2-dithiole-3- thione (D3T) and tert-butylhydroquinone (tBHQ), can enhance ARE-driven antioxidant expression and ameliorate and reverse the oxidant-..
  42. Enhanced Killing of Cancer Cell by Sulindac and Oxidative Stress
    Herbert Weissbach; Fiscal Year: 2007
    ..after exposure to sulindac show enhanced sensitivity to oxidative damage resulting from exposure to agents such as tert-butylhydroperoxide and hydrogen peroxide, resulting in loss of viability...
  43. MITOCHONDRIAL FUNCTION IN OXIDATIVE INJURY
    Anna Liisa Nieminen; Fiscal Year: 1999
    ..Specifically, I will evaluate the role of the mitochondrial permeability transition in toxic injury induced tert-butylhydroperoxide (t-BuOOH), menadione and extracellular ATP...
  44. JAVIER GUILLERMO BLANCO; Fiscal Year: 2016
    ..5-fold) in the presence of the prototypical antioxidant tert-butylhydroquinone and that the CBR3 promoter contains 2 conserved antioxidant response elements (AREs)...
  45. Regulation of the Expression of G[alpha]i2 by Reactive Oxygen Species
    Ifeanyi J Arinze; Fiscal Year: 2012
    ..To elevate ROS levels, the cells will be exposed to the electrophile tert-butylhydroquinone or to H2O2. RELEVANCE...
  46. Regulation of PMCA Pump-Channels by Oxidant Stress
    William P Schilling; Fiscal Year: 2010
    ..by MTX in vascular endothelial cells are biophysically identical to the channels activated by the model oxidant, tert-butyl-hydroperoxide or by oxidized glutathione (GSSG)...
  47. Ashraf Gorgey; Fiscal Year: 2016
    ..also unknown whether enhancing the decline anabolic homeostasis by providing testosterone (T) replacement therapy (TRT) would reverse body composition and metabolic profile changes in veterans with SCI...
  48. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Effect modification by gene SNP alleles related to telomere length (TERT, TRF1, TNKS1, TRF2, RAP1, POT1, and rs12696304 near TERC) will also be tested...
  49. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..Postnatal testosterone replacement therapy (TRT) completed testicular descent into the scrotum and concomitantly normalized estradiol concentrations in the ..
  50. A Novel Synthetic Androgen Receptor Antagonist
    Zhongyun Dong; Fiscal Year: 2012
    ..Dr. Dong's laboratory has identified a novel synthetic compound 6-amino-2-[2-(4-tert- butyl-pnenoxy)-ethylsulfanyl]-1H-pyrimidin-4-one, named DL3 for simplicity, as a potent AR antagonist...
  51. DAVID ALBERT SCHWARTZ; Fiscal Year: 2016
    ..Rare mutations in genes that maintain telomere length (TERT and TERC) have been reported to be associated with the development of FIP (defined as e 2 cases of IIP in one ..
  52. MEASUREMENT ERRORS IN ENVIRONMENTAL EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ..these new methods in a number of publications on the health effects of environmental exposure to endotoxin, methyl tert-butyl ether, lead, and indoor NO2, and developed publicly available software...
  53. Social status, cellular aging, and mortality
    Elissa S Epel; Fiscal Year: 2012
    ..We will measure telomere length and polymorphisms in three genes (TERT, TERC, PINX1) that regulate telomere length from archived DNA in approximately 7,200 men and women, aged 20 to 85+, ..
  54. Sioban D Harlow; Fiscal Year: 2016
    ..edu E-Mat^ trt^@ui7tich.edu 14...
  55. Preliminary Clinical Trial of New Therapy for Patients with Severe Tinnitus
    RUTH QUILLIAN WOLEVER; Fiscal Year: 2012
    ..5 Furthermore, commonly used forms of SBE [e.g.,Tinnitus Retraining Therapy (TRT)] can require over a year to become effective and may not be used in patients with hearing that is too poor to be ..
  56. Noah D Sabin; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Survivors of childhood cancer treated with thoracic radiation therapy (TRT) are at risk for cardiovascular and pulmonary morbidity, though risk is not recognized for Central Nervous System (CNS) ..
  57. Margaret R Wrensch; Fiscal Year: 2015
    ..Two of the glioma risk genes, TERT and RTEL1, are related to telomere maintenance...
  58. Roberta W Scherer; Fiscal Year: 2016
    ..Therapy Trial (TRTT) is a five-year study designed to investigate the efficacy of tinnitus retraining therapy (TRT) and its component parts, directive counseling (DC) and sound therapy (ST)...
  59. Nina B Wallerstein; Fiscal Year: 2014
    ..Initial RezRIDERS activities to develop the adult Tribal Research Team (TRT) (being conducted under a one-year developmental UNM Clinical and Translational Science Center [CTSC] mini-grant) ..
  60. Eric C Frey; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Targeted radionuclide therapy (TRT) plays an increasingly important role in treatment of a number of cancers including thyroid cancer and non-Hodgkins lymphoma...
  61. Continued Development of Photoelectrocatalytic Oxidation for Treating Gasoline Co
    TERENCE PATRICK BARRY; Fiscal Year: 2012
    ..benzene, ethyl benzene, toluene, and three isomers of xylene, and (2) fuel oxygenates, particularly methyl tert-butyl ether (MTBE). These chemicals are a significant risk to human health...
  62. Niklas Krause; Fiscal Year: 2016
    ..Program (P/SPP), and a Hazardous Substances Training (HST) Program and a Targeted Research Training Program (TRT)...
  63. CHARLES CRAIG FORMBY; Fiscal Year: 2016
    ..Therapy Trial (TRTT) is a five-year study designed to investigate the efficacy of tinnitus retraining therapy (TRT) and its component parts, directive counseling (DC) and sound therapy (ST)...

Patents1

  1. Human telomerase catalytic subunit
    Patent Number: EP1333094-A2; Date:2003-08-06