TCF4

Summary

Gene Symbol: TCF4
Description: transcription factor 4
Alias: E2-2, FECD3, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19, transcription factor 4, SL3-3 enhancer factor 2, class B basic helix-loop-helix protein 19, immunoglobulin transcription factor 2
Species: human

Top Publications

  1. pmc Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome)
    Christiane Zweier
    Institute of Human Genetics, Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Hum Genet 80:994-1001. 2007
  2. pmc SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4
    Motomasa Ihara
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Mol Cell Biol 25:3506-18. 2005
  3. ncbi Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes
    Andrea Rossi
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 N 12th Street 015 96, Philadelphia, PA 19122, USA
    J Gen Virol 87:1613-23. 2006
  4. pmc CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers
    Seung Kyoon Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Department of Functional Genomics, University of Science and Technology, 52 Eoeun dong, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Carcinogenesis 29:1623-31. 2008
  5. pmc Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
    M E Massari
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Mol Cell Biol 18:3130-9. 1998
  6. pmc A novel target recognition revealed by calmodulin in complex with the basic helix--loop--helix transcription factor SEF2-1/E2-2
    G Larsson
    Department of Medical Biosciences, Biophysics, University of Umea, S 901 87 Umea, Sweden
    Protein Sci 10:169-86. 2001
  7. ncbi Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription
    Imma Raurell
    Unitat de Biofisica, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    J Biol Chem 281:1401-11. 2006
  8. ncbi Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
  9. ncbi SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation
    Haruhisa Iguchi
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 282:19052-61. 2007
  10. ncbi Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
    P Henthorn
    Howard Hughes Medical Institute, Philadelphia, PA
    Science 247:467-70. 1990

Research Grants

  1. CHARACTERIZING MURINE GI STEM CELLS: NEW MOLECULAR TOOLS
    Bruce Boman; Fiscal Year: 2004
  2. Identify and characterize novel Wnt pathway genes
    Brian Harfe; Fiscal Year: 2006
  3. Mechanisms of gastrointestinal cell responses to Notch Signaling
    Tae Hee Kim; Fiscal Year: 2013
  4. Ramesh A Shivdasani; Fiscal Year: 2016
  5. Gabrielle Kardon; Fiscal Year: 2016
  6. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
  7. Elaine Fuchs; Fiscal Year: 2016
  8. Molecular Control of Shh-Gli Signaling in the Vertebrate CNS
    Michael P Matise; Fiscal Year: 2010
  9. Functional characterization of pathways regulated by schizophrenia gene TCF4
    JOSEPH LOUIE MCCLAY; Fiscal Year: 2013
  10. Hoang Nguyen; Fiscal Year: 2014

Detail Information

Publications219 found, 100 shown here

  1. pmc Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome)
    Christiane Zweier
    Institute of Human Genetics, Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Am J Hum Genet 80:994-1001. 2007
    ..2-Mb deletion on 18q21.2 in one patient. Sequencing of the TCF4 transcription factor gene, which is contained in the deletion region, in 30 patients with significant phenotypic ..
  2. pmc SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4
    Motomasa Ihara
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Mol Cell Biol 25:3506-18. 2005
    ..These results suggest that sumoylation of Lys(35) in PIASy determines the nuclear localization of PIASy and that it is necessary for PIASy-dependent sumoylation and transcriptional activation of Tcf-4...
  3. ncbi Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes
    Andrea Rossi
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 N 12th Street 015 96, Philadelphia, PA 19122, USA
    J Gen Virol 87:1613-23. 2006
    ..Here, the physical interaction and a functional consequence of TCF4-Sp1 contact were characterized...
  4. pmc CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is associated with gene silencing in intestinal-type gastric cancers
    Seung Kyoon Kim
    Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Department of Functional Genomics, University of Science and Technology, 52 Eoeun dong, Yuseong Gu, Daejeon 305 806, Republic of Korea
    Carcinogenesis 29:1623-31. 2008
    Transcriptional factor 4 (TCF4), encoding a basic helix-loop-helix transcriptional factor, has recently been demonstrated as a causative gene for Pitt-Hopkins syndrome, a neurodevelopmental disease...
  5. pmc Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
    M E Massari
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Mol Cell Biol 18:3130-9. 1998
    ..ABF-1 represents the first example of a B-cell-restricted bHLH protein, and its expression pattern suggests that ABF-1 may play a role in regulating antigen-dependent B-cell differentiation...
  6. pmc A novel target recognition revealed by calmodulin in complex with the basic helix--loop--helix transcription factor SEF2-1/E2-2
    G Larsson
    Department of Medical Biosciences, Biophysics, University of Umea, S 901 87 Umea, Sweden
    Protein Sci 10:169-86. 2001
    ..dimeric peptide corresponding to the DNA-binding domains of the dimeric basic helix-loop-helix transcription factor SEF2-1 (SEF2-1mp) using NMR...
  7. ncbi Presenilin-1 interacts with plakoglobin and enhances plakoglobin-Tcf-4 association. Implications for the regulation of beta-catenin/Tcf-4-dependent transcription
    Imma Raurell
    Unitat de Biofisica, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    J Biol Chem 281:1401-11. 2006
    ..These results provide a new explanation for the effects of PS1 on gene transcription mediated by beta-catenin in epithelial cells...
  8. ncbi Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
    ..Identification of the functional interaction of Ku70 as well as PARP-1 with the TCF-4 and beta-catenin transcriptional complex may provide insights into a novel linkage between DNA damage recognition/repair and Wnt signaling...
  9. ncbi SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation
    Haruhisa Iguchi
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 282:19052-61. 2007
    ..The data presented suggest that SOX6 may be an important factor in obesity-related insulin resistance...
  10. ncbi Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
    P Henthorn
    Howard Hughes Medical Institute, Philadelphia, PA
    Science 247:467-70. 1990
    ..The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation...
  11. pmc Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1
    E M Sampson
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    EMBO J 20:4500-11. 2001
    ..The apparent mechanism is an inhibition of TCF/LEF DNA binding through a physical interaction with HBP1. These data suggest that the suppression of Wnt signaling by HBP1 may be a mechanism to prevent inappropriate proliferation...
  12. ncbi The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway
    Giancarlo Ghiselli
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:20259-67. 2003
    ..of ApcMin/+ mice has led us to hypothesize that SMC3 expression is linked to activation of the APC/beta-catenin/TCF4 pathway...
  13. ncbi A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4
    Avital L Amir
    Cancer Biology Program, Hematology Oncology Division, The Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:30828-34. 2003
    ..This study demonstrates that there is a direct interaction between the AR DNA binding domain (DBD) and Tcf4. Tcf4 bound specifically to a glutathione S-transferase-ARDBD fusion protein and could be coimmunoprecipitated with ..
  14. pmc Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
    Laurence Levy
    Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 75015 Paris, France
    Mol Cell Biol 24:3404-14. 2004
    ..Acetylation of this residue increased the affinity of beta-catenin for Tcf4, and the cellular Tcf4-bound pool of beta-catenin was significantly enriched in acetylated form...
  15. ncbi Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 437:281-5. 2005
    ..Here we show that phosphorylated c-Jun interacts with the HMG-box transcription factor TCF4 to form a ternary complex containing c-Jun, TCF4 and beta-catenin...
  16. ncbi NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)
    Misato Yamada
    Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, JST, Chiyoda ku, Japan
    J Biol Chem 281:20749-60. 2006
    ..Collectively, our findings raise the possibility that NARF functions as a novel ubiquitin-ligase to suppress the Wnt-beta-catenin signaling...
  17. pmc CBP/p300 are bimodal regulators of Wnt signaling
    Jiong Li
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    EMBO J 26:2284-94. 2007
    ..cell line, we show that CBP and p300 can inhibit Wnt signaling and demonstrate that human p300 can bind directly to TCF4 in vitro...
  18. pmc Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction
    Jeanne Amiel
    From the Departments of Genetics, Pediatric Radiology and INSERM U 797, Universite Paris Descartes, Faculte de Medecine, Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Am J Hum Genet 80:988-93. 2007
    ..identified two de novo heterozygous missense mutations of a conserved amino acid in the basic region of the TCF4 gene in three additional subjects with PHS...
  19. ncbi Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4
    Antje Brockschmidt
    1Institute of Human Genetics, Rheinische Friedrich Wilhelms University, 53111 Bonn, Germany
    Hum Mol Genet 16:1488-94. 2007
    ..5 Mb deletion in 18q21.2 containing a single gene, the basic helix-loop-helix transcription factor TCF4. cDNA and genomic analyses in the patient and her parents demonstrated TCF4 haploinsufficiency as the underlying ..
  20. doi Disruption of the TCF4 gene in a girl with mental retardation but without the classical Pitt-Hopkins syndrome
    Vera M Kalscheuer
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Am J Med Genet A 146:2053-9. 2008
    ..fluorescence in situ hybridization indicated that on chromosome 18, the basic helix-loop-helix transcription factor TCF4 gene is disrupted by the breakpoint. TCF4 plays a role in cell fate determination and differentiation...
  21. doi Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B
    Maho Nagasawa
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 38:2389-400. 2008
    ..Together our results provide additional insight into the transcriptional network controlling pDC development as evidenced by the joint venture of E2-2 and Spi-B...
  22. pmc Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    BABACAR CISSE
    Department of Microbiology, Columbia University Medical Center, New York, NY 10032, USA
    Cell 135:37-48. 2008
    ..We report that basic helix-loop-helix transcription factor (E protein) E2-2/Tcf4 is preferentially expressed in murine and human PDCs...
  23. doi Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome
    Loic de Pontual
    Unité INSERM U 781, Universite Paris Descartes, Faculte de Medecine, INSERM
    Hum Mutat 30:669-76. 2009
    Pitt-Hopkins syndrome is a severe congenital encephalopathy recently ascribed to de novo heterozygous TCF4 gene mutations...
  24. pmc TCF4, schizophrenia, and Pitt-Hopkins Syndrome
    Derek J Blake
    Department of Psychological Medicine and Neurology, Medical Research Council Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Bull 36:443-7. 2010
    ..studies found, in addition to several other markers, a single nucleotide polymorphism in intron 4 of the TCF4 gene that was associated with schizophrenia...
  25. doi Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese
    Tao Li
    Bio X Center, Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Biol Psychiatry 68:671-3. 2010
    ..examined 7662 schizophrenic cases and 29053 normal control subjects and reported seven common single nucleotide polymorphisms (SNPs) that were significantly (>10(-8)) associated with schizophrenia...
  26. doi E2-2 protein and Fuchs's corneal dystrophy
    Keith H Baratz
    Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA
    N Engl J Med 363:1016-24. 2010
    ..Although rare genetic variation that contributes to both early-onset and typical late-onset forms of FCD has been identified, to our knowledge, no common variants have been reported...
  27. doi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..These comprise in schizophrenia, SNPs in or in the vicinity of transcription factor 4 (TCF4), neurogranin (NRGN) and an extended region covering the MHC locus on chromosome 6...
  28. pmc Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus
    S Amer Riazuddin
    Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 52:2825-9. 2011
    ..Recently, rs613872, an intronic variation of TCF4 associated with late-onset FCD, was reported...
  29. doi The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Division of Experimental and Clinical Pharmacopsychology, University of Zurich, CH 8032 Zurich, Switzerland
    J Neurosci 31:6684-91. 2011
    In a large-scale meta-analysis, it has been recently shown that the transcription factor 4 (TCF4) gene is among the most prominent susceptibility genes for schizophrenia...
  30. doi Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese
    Anbupalam Thalamuthu
    Genome Institute of Singapore, Singapore
    Invest Ophthalmol Vis Sci 52:5573-8. 2011
    To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD.
  31. pmc Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing
    Mari Sepp
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    PLoS ONE 6:e22138. 2011
    b>Transcription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2) is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG)...
  32. pmc Common variants at VRK2 and TCF4 conferring risk of schizophrenia
    Stacy Steinberg
    deCODE Genetics, IS 101 Reykjavik, Iceland
    Hum Mol Genet 20:4076-81. 2011
    ..alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of ..
  33. pmc Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, UK
    Am J Med Genet B Neuropsychiatr Genet 156:781-4. 2011
    ..Among these, transcription factor 4 (TCF4) is one of the best supported although the associated SNP (rs9960767) is located within intron 3 and ..
  34. pmc β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness
    Ester Sánchez-Tilló
    Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, Institut d Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:19204-9. 2011
    ..We found that β-catenin/TCF4 binds directly to the ZEB1 promoter and activates its transcription...
  35. doi Role of the TCF4 gene intronic variant in normal variation of corneal endothelium
    David A Mackey
    Lions Eye Institute, Western Australia, Australia
    Cornea 31:162-6. 2012
    To identify early features of Fuchs endothelial dystrophy (FED) in carriers of the rs613872(G) transcription factor 4 gene (TCF4) aged 20 to 21 years.
  36. doi Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells
    Rong Lu
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat Sen University, Guangzhou, People s Republic of China
    Stem Cells 30:753-61. 2012
    b>TCF4, a key transcription factor of Wnt signaling system, has been recently found to be essential for maintaining stem cells. However, its signaling pathway is not well elucidated...
  37. pmc Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process
    Abraham Kuot
    Department of Ophthalmology, Flinders University, Bedford Park, South Australia, Australia
    Eur J Hum Genet 20:632-8. 2012
    ..Recent studies reported significant association of polymorphisms in the TCF4 (transcription factor 4) gene, and a borderline association of PTPRG (protein tyrosine phosphatase, receptor type, G) variants ..
  38. doi Transcription factor 4 and myocyte enhancer factor 2C mutations are not common causes of Rett syndrome
    Roksana Armani
    NSW Centre for Rett Syndrome Research, Kids Research Institute, The Children s Hospital at Westmead, Sydney, NSW, Australia
    Am J Med Genet A 158:713-9. 2012
    ..More recently, it has been suggested that phenotypes associated with TCF4 and MEF2C mutations may represent a form of RTT...
  39. doi Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects
    Mari Sepp
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn, Estonia
    Hum Mol Genet 21:2873-88. 2012
    Transcription factor TCF4 (alias ITF2, SEF2 or E2-2) is a broadly expressed basic helix-loop-helix (bHLH) protein that functions as a homo- or heterodimer...
  40. doi Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome
    Marc Forrest
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mutat 33:1676-86. 2012
    ..Autosomal dominant PTHS is caused by mutations in the transcription factor 4 (TCF4) gene, whereas NRXN1 and CNTNAP2 mutations are associated with autosomal recessive PTHS...
  41. pmc TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders
    K V Wirgenes
    Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Transl Psychiatry 2:e112. 2012
    b>TCF4 is involved in neurodevelopment, and intergenic and intronic variants in or close to the TCF4 gene have been associated with susceptibility to schizophrenia...
  42. doi Confirmation of the association between the TCF4 risk allele and Fuchs endothelial corneal dystrophy in patients from the Midwestern United States
    John F Stamler
    Department of Ophthalmology and Visual Sciences, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Ophthalmic Genet 34:32-4. 2013
    To determine the role of the single nucleotide polymorphism (SNP) (rs613872) in the TCF4 gene in Fuchs endothelial corneal dystrophy (FECD) in patients from Iowa.
  43. pmc Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy
    Robert P Igo
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e46742. 2012
    ..between FECD and central corneal thickness (CCT), we characterized common genetic variation in COL8A2 and TCF4, genes previously implicated in CCT and/or FECD...
  44. doi TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease
    Katherinne Navarrete
    Social, Genetic and Developmental Psychiatry Centre, King s College London, Institute of Psychiatry, London, UK
    Am J Med Genet B Neuropsychiatr Genet 162:1-16. 2013
    Common SNPs in the transcription factor 4 (TCF4; ITF2, E2-2, SEF-2) gene, which encodes a basic Helix-Loop-Helix (bHLH) transcription factor, are associated with schizophrenia, conferring a small increase in risk...
  45. pmc Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4
    S Amer Riazuddin
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 93:758-64. 2013
    ..Finally, we show that AGBL1 interacts biochemically with the FCD-associated protein TCF4 and that the mutations found in our cohort of FCD individuals diminish this interaction...
  46. doi The emerging roles of TCF4 in disease and development
    Marc P Forrest
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    Trends Mol Med 20:322-31. 2014
    Genome-wide association studies have identified common variants in transcription factor 4 (TCF4) as susceptibility loci for schizophrenia, Fuchs' endothelial corneal dystrophy, and primary sclerosing cholangitis...
  47. pmc Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers
    B Corneliussen
    Department of Applied Cell and Molecular Biology, University of Umea, Sweden
    J Virol 65:6084-93. 1991
    A family of nuclear proteins, designated SL3-3 enhancer factors 2 (SEF2), were found to interact with an Ephrussi box-like motif within the glucocorticoid response element in the enhancer of the murine leukemia virus SL3-3...
  48. pmc The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene
    A Pscherer
    Institut fur Pathologie, Universitat Regensburg, Germany
    EMBO J 15:6680-90. 1996
    ..In summary, the SSTR2inr represents a novel type of initiator element that confers gene expression in the absence of a TATA-box or binding sites for other known initiator factors, like YY-1 or USF...
  49. ncbi A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1
    T S Breschel
    George Browne Genetics Laboratory, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 6:1855-63. 1997
    ..1. The CTG repeat locus, termed CTG18.1, is located within an intron of human SEF2-1, a gene encoding a basic hellx-loop-hellx DNA binding protein involved in transcriptional regulation...
  50. ncbi A splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box
    Y Liu
    Department of Internal Medicine and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 273:19269-76. 1998
    ..These cDNA clones represent the variant of bHLH protein E2-2/SEF2-1 in having 12 additional nucleotides encoding the amino acids RSRS...
  51. ncbi HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex
    P Persson
    Department of Laboratory Medicine, Lund University, Malmo, University Hospital MAS, S 205 02, Sweden
    Biochem Biophys Res Commun 274:22-31. 2000
    ..Two of the isolated clones contained cDNA from the E2-2 gene (also known as ITF2/SEF2-1). We show that E2-2 interacts with HASH-1 in both yeast and mammalian cells...
  52. pmc Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
    Hideki Yamamoto
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 22:2047-59. 2003
    ..These results suggest that sumoylation of Tcf-4 is involved in beta-catenin-dependent and Tcf-4-mediated gene expression in the Wnt signaling pathway...
  53. pmc The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells
    Emmelie A Jansson
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:1460-5. 2005
    ..Mechanistically, PPARgamma, through interactions with beta-catenin and T cell transcription factor (Tcf)-4, may be a determinant of cell fate and is likely a target of the Wnt pathway in cancer cells...
  54. ncbi Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells
    Malathy P V Shekhar
    Breast Cancer Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Mol Cancer Res 4:729-45. 2006
    ....
  55. doi Deletion 18q21.2q21.32 involving TCF4 in a boy diagnosed by CGH-array
    Joris Andrieux
    Laboratoires de Génétique Médicale, Hopital Jeanne de Flandre, CHRU de Lille, France
    Eur J Med Genet 51:172-7. 2008
    ..CGH-array allowed characterisation of a de novo 6.2 Mb 18q21.2q21.32 interstitial deletion involving TCF4, the recently identified gene responsible for Pitt-Hopkins syndrome (PHS)...
  56. doi TCF4 deletions in Pitt-Hopkins Syndrome
    Irina Giurgea
    INSERM U841, IMRB, Département de génétique, Equipe 11, Creteil, F 94000, France
    Hum Mutat 29:E242-51. 2008
    ..PHS was shown to be caused by de novo heterozygous mutations of the TCF4 gene, located in 18q21...
  57. pmc Common variants conferring risk of schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 460:744-7. 2009
    ..3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2...
  58. pmc Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy
    Yi Ju Li
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e18044. 2011
    ..a recently reported genome-wide association study identified common alleles at a locus on chromosome 18 near TCF4 which confer susceptibility to FECD...
  59. pmc Associations between TCF4 gene polymorphism and cognitive functions in schizophrenia patients and healthy controls
    Xianghua Zhu
    People s Dong fang Hospital of Xuzhou, Xuzhou, China
    Neuropsychopharmacology 38:683-9. 2013
    ..Future research is needed to replicate these results and to explore the biochemical mechanisms behind this association...
  60. doi Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease
    J Wehkamp
    Robert Bosch Hospital, Internal Medicine I, Stuttgart, Germany
    Mucosal Immunol 1:S67-74. 2008
    ..In the majority of patients, the Paneth-cell deficiency is mediated by Wnt-TCF4, which suggests a disturbed Paneth-cell differentiation...
  61. pmc Peptidyl-tRNA hydrolase from Sulfolobus solfataricus
    Michel Fromant
    Laboratoire de Biochimie, Unité Mixte de Recherche 7654, CNRS Ecole Polytechnique, 91128 Palaiseau Cedex, France
    Nucleic Acids Res 31:3227-35. 2003
    ..coli strain lacking PTH activity. The archaeal gene, the product of which appears markedly different from bacterial PTHs, also has homologs in all the available eukaryal genomes...
  62. pmc Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells
    Makoto Saegusa
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Am J Pathol 164:1739-49. 2004
    ..an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs...
  63. doi In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice
    Marc Lutgehetmann
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Hepatology 52:16-24. 2010
    ..Primary tupaia hepatocytes (PTHs) chronically infected with woolly monkey HBV (WM-HBV) were isolated from one highly viremic uPA/SCID chimeric mouse ..
  64. ncbi Applicability of a modified Edman procedure for measurement of protein adducts: mechanisms of formation and degradation of phenylthiohydantoins
    Per Rydberg
    Department of Environmental Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
    Chem Res Toxicol 15:570-81. 2002
    ..The rapid cyclization to N-alkylvaline-PTHs occurs as a consequence of the influence of substituents on ring formation...
  65. ncbi Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression
    A Lampen
    Institut für Lebensmitteltoxikologie, Stiftung Tierarztliche Hochschule Hannover, Germany
    Biochim Biophys Acta 1735:30-40. 2005
    ..with peroxisome proliferator-activated receptors (PPARs), and expression of genes relevant in the APC-beta-catenin-TCF4 signalling pathway in human HT-29 and Caco-2 colon cells...
  66. pmc Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria
    Lidia Hernandez
    Cancer and Developmental Biology Laboratory, NCI, Frederick, MD 21702, USA
    Dev Cell 19:413-25. 2010
    ..of canonical Wnt signaling, due to reduced nuclear localization and transcriptional activity of Lef1, but not Tcf4, in both mouse and human progeric cells...
  67. pmc Crohn's disease--defect in innate defence
    Michael Gersemann
    Internal Medicine I, Robert Bosch Hospital, Auerbachstrasse 110, Stuttgart, Germany
    World J Gastroenterol 14:5499-503. 2008
    ..ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation...
  68. ncbi Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer
    Sung Chul Lim
    Department of Pathology, College of Medicine, Chosun University Hospital, Dong Ku, Kwangju, Korea
    Oncol Rep 9:915-28. 2002
    ..plays also a role in intracellular signaling and can function as an oncogene when binds to the T-cell factor 4 (Tcf4)-binding site in the promotor region of cyclin D1 and transactivates genes after translocation to the nucleus...
  69. ncbi Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli cell differentiation
    Terla Muir
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 73:491-500. 2006
    ..The ubiquitous bHLH protein ITF2 (i.e., E2-2) was identified as one of the interacting partners...
  70. pmc Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity
    Shumei Song
    Department of Gastroenterology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 69:1343-9. 2009
    ..Reduction of galectin-3 led to reduced nuclear beta-catenin with a concomitant decrease in TCF4 transcriptional activity and expression of its target genes...
  71. ncbi Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    Wendy Balemans
    Department of Medical Genetics, University and University Hospital of Antwerp, Antwerp, Belgium
    J Bone Miner Res 22:708-16. 2007
    ..In vitro studies suggest that a reduced antagonistic effect of DKK1 on canonical Wnt signaling contributes to the molecular effect of this mutation and its pathogenic consequence...
  72. pmc HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
    J S Hu
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Mol Cell Biol 12:1031-42. 1992
    ..complete identity in the B-HLH domain with the immunoglobulin enhancer binding proteins encoded by the E2A and ITF2 genes (E proteins)...
  73. pmc The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
    Giancarlo Ghiselli
    Department of Pathology and Cell Biology, Thomas Jefferson University, 1020 Locust Street, JAH 371, Philadelphia, PA 19107, USA
    Biochem J 390:493-9. 2005
    ..constructs have shed light on the functional relevance of two cis-acting binding elements for the beta-catenin-TCF4 complex (where TCF4 stands for T-cell factor 4) that are located in the enhancer region of the promoter...
  74. pmc The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element
    Thankam Paul
    Department of Pediatrics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Biochem J 408:317-26. 2007
    ..and Cdx2 (caudal homeobox protein 2) occupy and regulate through a novel intronic enhancer element of CFTR and that Tcf4 (T-cell factor 4) overlaps the same DNA element...
  75. doi Menin promotes the Wnt signaling pathway in pancreatic endocrine cells
    Gao Chen
    David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 6904, USA
    Mol Cancer Res 6:1894-907. 2008
    ..proteins involved in the canonical Wnt signaling pathway, including beta-catenin, TCF3 (TCFL1), and weakly with TCF4 (TCFL2)...
  76. pmc The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
    Thomas W Sturgill
    Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Cancer 9:104. 2010
    ..3 kb. We hypothesized ICK and FBX9 are potentially important genes in cancer controlled by a bidirectional promoter...
  77. ncbi Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2
    E Matsunaga
    Department of Molecular Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo machi 4 1, Aoba ku, Sendai 980 8575, Japan
    Development 127:2357-65. 2000
    ..Pax6 repressed En1, Pax2 and other tectum (mesencephalon)-related genes such as En2, Pax5, Pax7, but induced Tcf4, a diencephalon marker gene...
  78. ncbi Somatic frameshift alterations in mononucleotide repeat-containing genes in different tumor types from an HNPCC family with germline MSH2 mutation
    M Planck
    Department of Oncology, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 29:33-9. 2000
    ..g., TGFBRII, BAX, IGFIIR, TCF4, MSH3, and MSH6...
  79. ncbi Structural analysis of the group II intron splicing factor CRS2 yields insights into its protein and RNA interaction surfaces
    Gerard J Ostheimer
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    J Mol Biol 345:51-68. 2005
    ..The CRS2 amino acid sequence is closely related to those of bacterial peptidyl-tRNA hydrolases (PTHs)...
  80. ncbi Comparative genomics on FGF16 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:959-63. 2005
    ..Because nuclear complex consisting of TCF/LEF (TCF1, TCF3, TCF4 or LEF1), beta-catenin, PYGO (PYGO1 or PYGO2) and Legless (BCL9 or BCL9L) binds to the TCF/LEF-binding site to up-..
  81. ncbi Application of NKF-K/DOQI Clinical Practice Guidelines for Bone Metabolism and Disease: changes of clinical practices and their effects on outcomes and quality standards in three haemodialysis units
    M Dolores Arenas
    Hospital Perpetuo Socorro, Alicante, Elche y Elda, Spain
    Nephrol Dial Transplant 21:1663-8. 2006
    ..The objective of this study was to analyse the effect of the application of those guidelines on clinical practices and on the achievement of bone disease targets and quality standards...
  82. ncbi Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells
    Marcus Pickhardt
    Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, D 22607 Hamburg, Germany
    Biochemistry 46:10016-23. 2007
    ..7 microM and DC50 = 10.8 microM). We have now synthesized 49 similar structures and identified the core of the PTHs to be crucial for activity, thus representing a lead structure...
  83. doi Spatiotemporal pattern analysis of transcription factor 4 in the developing anorectum of the rat embryo with anorectal malformations
    Tao Zhang
    Department of Pediatric Surgery, Shengjing Hospital China Medical University, Heping District, Shenyang 110004, People s Republic of China
    Int J Colorectal Dis 24:1039-47. 2009
    As a member of the transcription factors family, transcription factor 4(Tcf4) is known to influence gene expression in endodermally derived tissues including lung, liver, pancreas, stomach, and intestine...
  84. doi Molecular development of the lateral geniculate nucleus in the absence of retinal waves during the time of retinal axon eye-specific segregation
    L Iwai
    Department of Molecular and Systems Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Neuroscience 159:1326-37. 2009
    ..The expression levels of Purkinje cell protein 4 (PCP4/PEP19), transcription factor 7-like 2 (TCF7L2/TCF4) and LIM homeobox protein 9 (Lhx9) in the LGN change significantly during eye-specific segregation...
  85. doi Innate antimicrobial host defense in small intestinal Crohn's disease
    Maureen J Koslowski
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
    Int J Med Microbiol 300:34-40. 2010
    ..has been found which is linked to diminished levels of the Wnt pathway transcription factor TCF7L2 (also known as TCF4)...
  86. pmc NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation
    E E Bosco
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Oncogene 29:2540-9. 2010
    ..NF2-deficient cells, was able to suppress elevated Wnt signals as shown by reduced activity of the T-cell factor 4 (TCF4) transcription factor...
  87. doi Autotaxin controls caudal diencephalon-mesencephalon development in the chick
    Hideyo Ohuchi
    Department of Life Systems, Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan
    Dev Dyn 239:2647-58. 2010
    ..RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal ..
  88. pmc Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype
    Krzysztof Mrozek
    Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 1228, USA
    Semin Oncol 35:365-77. 2008
    ..candidate genes have been identified as targets of genomic losses, for example, TP53, CTNNA1, NF1, ETV6, and TCF4, and amplifications, for example, ERG, ETS2, APP, ETS1, FLI1, MLL, DDX6, GAB2, MYC, TRIB1, and CDX2...
  89. pmc Connective tissue fibroblasts and Tcf4 regulate myogenesis
    Sam J Mathew
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Development 138:371-84. 2011
    ..Here, we show that the transcription factor Tcf4 (transcription factor 7-like 2; Tcf7l2) is strongly expressed in connective tissue fibroblasts and that Tcf4(GFPCre)..
  90. ncbi Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA
    Juha Saarikettu
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    J Biol Chem 279:41004-11. 2004
    ..sensor protein calmodulin can interact with the DNA binding basic helix-loop-helix (bHLH) domain of E12, E47, and SEF2-1 (E2-2), which belong to the E-protein subclass of bHLH transcription factors...
  91. pmc Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway
    M Brunori
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges, Switzerland
    J Virol 75:2857-65. 2001
    ..we have developed replicating adenoviruses that express the viral E1B and E2 genes from promoters controlled by the Tcf4 transcription factor...
  92. ncbi The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways
    Shi Lei
    Division of Gastroenterology, Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 279:42492-502. 2004
    ..in AGS cells in a similar fashion, as revealed by small interference RNA studies or overexpression of Smads and TCF4/beta-catenin...
  93. pmc TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors
    Michelle L Brinkmeier
    University of Michigan, Department of Human Genetics, 4909 Buhl Building, 1241 E Catherine, Ann Arbor, MI 48109 0618, USA
    Dev Biol 311:396-407. 2007
    ..expression of several members of this family during pituitary development and the functional role of one member, TCF4 (TCF7L2), in the induction of the pituitary primordium...
  94. doi Thiazolidinediones downregulate Wnt/beta-catenin signaling via multiple mechanisms in breast cancer cells
    Pei Shan Wang
    Department of Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Surg Res 153:210-6. 2009
    ..We sought to better define TZDs' antitumor effects and molecular mechanisms to permit rational utilization of these agents...
  95. doi Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta)
    Rachel L Clifford
    Centre for Respiratory Research, Clinical Sciences Building, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 283:35337-53. 2008
    ..Mutation of TCF sites and expression of dominant negative TCF4 abolished TGFbeta(1)-induced VEGF promoter activity...
  96. pmc Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets
    Andreas Weise
    Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Spemann Graduate School of Biology and Medicine, Albert Ludwigs University Freiburg, Germany
    Nucleic Acids Res 38:1964-81. 2010
    ..The mouse Tcf7l2 gene is subject to alternative splicing. It encodes TCF4, a member of the T-cell factor (TCF) family of DNA-binding proteins and a nuclear interaction partner of beta-..
  97. doi Two percent of patients suspected of having Angelman syndrome have TCF4 mutations
    K Takano
    Greenwood Genetic Center, Greenwood, SC 29646, USA
    Clin Genet 78:282-8. 2010
    ..Haploinsufficiency of the TCF4 gene has been found to be associated with the Pitt-Hopkins syndrome (PTHS)...
  98. pmc Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: implications for tissue engineering
    Natalina Quarto
    Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    Tissue Eng Part A 16:3185-97. 2010
    ..osteogenic differentiation of undifferentiated mesenchymal cells, whereas expression of dominant negative transcription factor 4 (Tcf4) and/or secreted frizzled related protein 1 treatment enhances their osteogenic differentiation...
  99. pmc An unstable trinucleotide-repeat region on chromosome 13 implicated in spinocerebellar ataxia: a common expansion locus
    J B Vincent
    Department of Genetics, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Am J Hum Genet 66:819-29. 2000
    ..Two unstable CAG/CTG repeats, SEF2-1B and ERDA1, have recently been cloned, and studies indicate that the majority of individuals with large repeats ..
  100. ncbi Thermodynamics of the high-affinity interaction of TCF4 with beta-catenin
    S Knapp
    Department of Structural Chemistry, Pharmacia Corporation, Discovery Research Oncology, Nerviano, Italy
    J Mol Biol 306:1179-89. 2001
    ..We have characterized the binding of TCF4 to human beta-catenin by steady-state intrinsic fluorescence quenching experiments, surface plasmon resonance (SPR) ..

Research Grants42

  1. CHARACTERIZING MURINE GI STEM CELLS: NEW MOLECULAR TOOLS
    Bruce Boman; Fiscal Year: 2004
    ..Here we will test one tool, GFP-Tcf4 transgenic mice...
  2. Identify and characterize novel Wnt pathway genes
    Brian Harfe; Fiscal Year: 2006
    ..In the mouse and chick limb the PIs have shown that Tcf4 is expressed in a population of cells that surrounds differentiating muscles ("perimuscular")...
  3. Mechanisms of gastrointestinal cell responses to Notch Signaling
    Tae Hee Kim; Fiscal Year: 2013
    ..I will analyze genome-wide binding of the secretory transcription factors Atoh1 and Tcf4, and test specific mechanistic hypotheses regarding their interactions in cell replication and in differentiation ..
  4. Ramesh A Shivdasani; Fiscal Year: 2016
    ..in gut epithelial progenitors, we will test the hypothesis that Atoh1 steers the Wnt-effector transcription factor Tcf4 away from cis-elements of proliferative genes and toward those of a Wnt- dependent secretory cell program...
  5. Gabrielle Kardon; Fiscal Year: 2016
    ..We identified that the transcription factor Tcf4 (Tcf7L2) is strongly expressed in adult connective tissue fibroblasts and in their precursors in the embryo...
  6. Pathways regulating plasmacytoid dendritic cells in Peyers Patches
    Stephanie S Watowich; Fiscal Year: 2013
    ..will be examined by transplant experiments with BM progenitors from Stat1-/-, STAT3-deficient, Ifnar-/- or Tcf4-/- (E2-2-deficient) mice in steady state or in response to cytokines that elicit BM and spleen pDC generation (i.e...
  7. Elaine Fuchs; Fiscal Year: 2016
    ..In HF-SCs, two family members-- Tcf3 and Tcf4--are co-expressed, where they function redundantly to repress differentiation in the absence of Wnt signaling and ..
  8. Molecular Control of Shh-Gli Signaling in the Vertebrate CNS
    Michael P Matise; Fiscal Year: 2010
    ..The experiments in Aim 1 will address the requirement for Tcf4, a key transcriptional regulator of canonical Wnt signaling, in neural development by examining targeted Tcf4 mouse ..
  9. Functional characterization of pathways regulated by schizophrenia gene TCF4
    JOSEPH LOUIE MCCLAY; Fiscal Year: 2013
    ..Arguably, the most exceptional empirical evidence is for TCF4 (transcription factor 4), a gene that consistently ranked among the top findings in the largest schizophrenia genetic studies to ..
  10. Hoang Nguyen; Fiscal Year: 2014
    ..Tcf3 and Tcf4 are HMG transcription factor members that either can activate gene transcription when bound to 2-catenin, or can ..
  11. Mouse Models of Sporadic Colorectal Cancer
    MELINDA ANGUS-HILL; Fiscal Year: 2012
    ..b>Tcf4 is a member of the Tcf/Lef family of transcription factors...
  12. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2013
    ..of uPAR and c-Myc as the target genes of 2-catenin/Tcf dependent transcription, and inhibition of 2-catenin/Tcf4 dependent transcription and its target gene expression by over-expressing Pdcd4...
  13. Mechanism of Myostatin Action
    Shalendar Bhasin; Fiscal Year: 2013
    ..We will determine whether myostatin down regulates TCF4 transcription and whether inhibition of TCF4 by dominant negative cDNA blocks myostatin effects on hMSC ..
  14. Heinz Josef Lenz; Fiscal Year: 2016
    ..Our central hypothesis is that increased CBP/[unreadable]-catenin/TCF4 driven transcription at the expense of p300/[unreadable]-catenin/TCF4-mediated transcription is associated with ..
  15. CHARLES ALFRED STANLEY; Fiscal Year: 2016
    ..genes, including the novel gene on 10q that will be identified in Aim 1, HADH/SCHAD, SLC16A1/MCT-1, TCF1/HNF1, TCF4/HNF4, SIR2L4/SIRT4, and others...
  16. Kishore K Wary; Fiscal Year: 2016
    ..how LPP3 promotes b-catenin- mediated transcriptional activation of T-cell factor-4/lymphoid enhancer factor-1 (TCF4/LEF-1) target genes...
  17. The role of MTGR1 in intestinal biology and inflammation
    Christopher S Williams; Fiscal Year: 2012
    ..We have found that MTG proteins bind TCF4 and repress WNT signal transduction resulting in de-regulation of TCF4 targets...
  18. Sudha K Iyengar; Fiscal Year: 2015
    ..g. smoking) and genotype-phenotype correlations at interesting loci (e.g. TCF4)...
  19. SEAN VAHRAM TAVTIGIAN; Fiscal Year: 2014
    ..with a focus on events related to decreased retinoic acid production, excess signaling through EGFR, LEF1, TCF4 and deregulated Wnt signaling. 3...
  20. VENKATESWARA VINOD MOOTHA; Fiscal Year: 2016
    ..A recent GWAS study found an association between SNPs spanning a 1 Mb region of chr 18q including TCF4/FLJ45743 and late-onset FECD, but the underlying causal variant remains elusive...
  21. Jin Peng Szatkiewicz; Fiscal Year: 2014
    ..of significant genome wide association for four genes which have confirmed miR-137 target sites (CACNA1C, TCF4, CSMD1, and C10orf26)...
  22. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..We will evaluate whether inhibition of beta-catenin by a silencer RNA blocks the activation of TCF4 and MyoD transcription by testosterone and DHT...
  23. Function of Myeloid Translocation Gene Related-1
    SCOTT HIEBERT; Fiscal Year: 2009
    ..We found that Mtgr1 associates with Tcf4, but not Math1 or Hes1. TCF4 is a DNA binding factor that mediates Wnt signaling in the small intestine...
  24. Therapeutic Targeting of Beta-Catenin in Colon Cancer
    Jeffrey Drebin; Fiscal Year: 2006
    ..will be evaluated, and compared with changes induced by upstream alterations in APC or downstream alterations in Tcf4 activity Effects of suppressing beta-catenin on spontaneous adenoma formation will be evaluated using APC-mutant ..
  25. Combinatorial Selection of Beta-Catenin/T Cell Factor Pathway Inhibitors
    David Gorenstein; Fiscal Year: 2007
    ..is to identify a tight-binding and highly specific ODN that will bind to the beta-catenin binding domain of human TCF4 (TCF-CBD) to block the beta-catenin binding with TCF and/or disrupt the beta-catenin and TCF interaction...
  26. SIGNALING IN INTESTINAL CANCER
    Leonard H Augenlicht; Fiscal Year: 2010
    ..abstract_text> ..
  27. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
    ..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
  28. Nutritional mechanisms and intestinal tumorigenesis
    Leonard Augenlicht; Fiscal Year: 2009
    ....
  29. FATTY ACID MODULATION OF COLON CELL TRANSFORMATION
    Leonard Augenlicht; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2008
    ..These cells will be assessed for growth and PSA secretion in tumours carried as xenografts. These novel in vivo tools will allow understanding to the role of Beta-catenin has in Al PrCa. ..
  31. Array-based methylation analysis using anti-5mC antibody
    Fumiichiro Yamamoto; Fiscal Year: 2007
    ..We will evaluate the sensitivity, specificity, and reproducibility of the method, using BAG clone microarrays, DNA fragment microarrays, and oligonucleotide microarrays. [unreadable] [unreadable] [unreadable]..
  32. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2006
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  33. Modulation of Intestinal Tumorigenesis
    Leonard Augenlicht; Fiscal Year: 2006
    ..abstract_text> ..
  34. Epigenetic Alterations in Homeotic Genes
    Fumiichiro Yamamoto; Fiscal Year: 2005
    ..Both the constitutive and inducible expression systems will be used to examine the tumor suppressor function of these homeotic genes. ..
  35. SITE SPECIFICITY OF GASTROINTESTINAL TUMORIGENESIS
    Leonard Augenlicht; Fiscal Year: 2004
    ..Lastly, using microarray analyses, the profiles of gene expression that characterize genetic and dietary modulation of risk will be defined. ..
  36. MOLECULAR CLASSIFICATION OF COLON TUMORS
    Leonard Augenlicht; Fiscal Year: 2004
    ..abstract_text> ..
  37. GENE INTERACTIONS IN COLON CANCER
    Leonard Augenlicht; Fiscal Year: 2003
    ....
  38. Coordination of Proliferation and Apoptosis
    Leonard Augenlicht; Fiscal Year: 2002
    ..Understanding the mechanism by which mitochondrial function coordinates cell maturation pathways in the intestinal mucosa has profound implications for understanding tumorigenesis and for effecting chemoprevention. ..
  39. COLON CANCER--MOLECULAR BIOLOGY OF CELL RESPONSE TO DIET
    Leonard Augenlicht; Fiscal Year: 2001
    ....
  40. CURCUMIN--MECHANISMS OF CHEMOPREVENTION
    Leonard Augenlicht; Fiscal Year: 2001
    ..On the other hand, differences in mechanism could suggest a study design in which curcumin was combined with sulindac or to other NSAIDs in a prevention trial to test whether the two agents give additive, or synergistic, effects. ..
  41. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..