TBX22

Summary

Gene Symbol: TBX22
Description: T-box 22
Alias: ABERS, CLPA, CPX, TBXX, dJ795G23.1, T-box transcription factor TBX22, T-box protein 22
Species: human

Top Publications

  1. ncbi The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia
    C Braybrook
    Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nat Genet 29:179-83. 2001
  2. ncbi Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients
    Claire Braybrook
    Institute of Reproductive and Developmental Biology, Imperial College Faculty of Medicine Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Hum Mol Genet 11:2793-804. 2002
  3. pmc TBX22 mutations are a frequent cause of cleft palate
    A C B Marçano
    J Med Genet 41:68-74. 2004
  4. ncbi Mutation analysis of TBX22 reveals new mutation in Tunisian CPX family
    Myriam Chaabouni
    Laboratoire de génétique humaine faculté de médecine de Tunis et service maladies héréditaires hôpital Charles Nicolle, Tunis
    Clin Dysmorphol 14:23-5. 2005
  5. ncbi PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses
    Eisaburo Ichikawa
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
    J Hum Genet 51:38-46. 2006
  6. ncbi Human genetic factors in nonsyndromic cleft lip and palate: an update
    Francesco Carinci
    Department of D M C C C, Section of Maxillofacial Surgery, University of Ferrara, Corso, Giovecca 203, 44100 Ferrara, Italy
    Int J Pediatr Otorhinolaryngol 71:1509-19. 2007
  7. pmc TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression
    Artemisia M Andreou
    Institute of Child Health, University College London, London, WC1N 1EH, UK
    Am J Hum Genet 81:700-12. 2007
  8. ncbi TBX22 mutations are a frequent cause of non-syndromic cleft palate in the Thai population
    K Suphapeetiporn
    Division of Medical Genetics and Metabolism, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Genet 72:478-83. 2007
  9. doi MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate
    Triin Jagomagi
    Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:213-20. 2010
  10. doi Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations
    P N Kantaputra
    Department of Orthodontics and Paediatric Dentistry, and Craniofacial Genetics Laboratory, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
    J Dent Res 90:450-5. 2011

Research Grants

  1. Energetics of Unfolding and Translocation by ClpA
    MELVA JAMES; Fiscal Year: 2007
  2. MECHANISM OF ACTION OF THE HSP100 CHAPERONE CLPA
    Arthur Horwich; Fiscal Year: 2006
  3. STRUCTURE AND FUNCTION OF HSP 100 PROTEINS
    Michal Zolkiewski; Fiscal Year: 2005
  4. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
  5. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. ncbi The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia
    C Braybrook
    Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nat Genet 29:179-83. 2001
    ..we show that CPX is caused by mutations in the gene encoding the recently described T-box transcription factor TBX22 (ref. 14)...
  2. ncbi Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients
    Claire Braybrook
    Institute of Reproductive and Developmental Biology, Imperial College Faculty of Medicine Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Hum Mol Genet 11:2793-804. 2002
    ..defect in CPX was identified, where unique mutations were found in the T-box-containing transcription factor TBX22. Here we report two new familial cases with novel missense and insertion mutations, each occurring within the T-..
  3. pmc TBX22 mutations are a frequent cause of cleft palate
    A C B Marçano
    J Med Genet 41:68-74. 2004
  4. ncbi Mutation analysis of TBX22 reveals new mutation in Tunisian CPX family
    Myriam Chaabouni
    Laboratoire de génétique humaine faculté de médecine de Tunis et service maladies héréditaires hôpital Charles Nicolle, Tunis
    Clin Dysmorphol 14:23-5. 2005
    ..Linkage studies resulted in mapping CPX to Xq13-q 21-31 region. TBX22 was identified as causing CPX...
  5. ncbi PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses
    Eisaburo Ichikawa
    Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan
    J Hum Genet 51:38-46. 2006
    ..population, relationships between CL/P or CPO and seven candidate genes (TGFB3, DLX3, PAX9, CLPTM1, TBX10, PVRL1, TBX22) that showed positive associations in other populations and are expressed in the oral/lip region in developing ..
  6. ncbi Human genetic factors in nonsyndromic cleft lip and palate: an update
    Francesco Carinci
    Department of D M C C C, Section of Maxillofacial Surgery, University of Ferrara, Corso, Giovecca 203, 44100 Ferrara, Italy
    Int J Pediatr Otorhinolaryngol 71:1509-19. 2007
    ..In addition, MTHFR, TGF-beta3, and RARalpha play a role in cleft onset. In CPI one gene has been identified (TBX22) at present, but others are probably involved...
  7. pmc TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression
    Artemisia M Andreou
    Institute of Child Health, University College London, London, WC1N 1EH, UK
    Am J Hum Genet 81:700-12. 2007
    The T-box transcription factor TBX22 is essential for normal craniofacial development, as demonstrated by the finding of nonsense, frameshift, splice-site, or missense mutations in patients with X-linked cleft palate (CPX) and ..
  8. ncbi TBX22 mutations are a frequent cause of non-syndromic cleft palate in the Thai population
    K Suphapeetiporn
    Division of Medical Genetics and Metabolism, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Genet 72:478-83. 2007
    Mutations in the TBX22 gene underlie an X-linked malformation syndrome with cleft palate (CP) and ankyloglossia. Its mutations also result in non-syndromic CP in some populations...
  9. doi MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate
    Triin Jagomagi
    Department of Stomatology, Faculty of Medicine, University of Tartu, Tartu, Estonia
    Eur J Oral Sci 118:213-20. 2010
    ..This study provides further evidence implicating MSX1 and MTHFR in the etiology of nonsyndromic CL/P across different populations...
  10. doi Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations
    P N Kantaputra
    Department of Orthodontics and Paediatric Dentistry, and Craniofacial Genetics Laboratory, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
    J Dent Res 90:450-5. 2011
    X-linked cleft palate and ankyloglossia (CPX) are caused by mutations in the TBX22 transcription factor...
  11. ncbi Role of Hsp70 (DnaK-DnaJ-GrpE) and Hsp100 (ClpA and ClpB) chaperones in refolding and increased thermal stability of bacterial luciferases in Escherichia coli cells
    G B Zavilgelsky
    State Scientific Center of the Russian Federation GosNIIgenetika, Moscow, 117545, Russia
    Biochemistry (Mosc) 67:986-92. 2002
    The role of chaperones Hsp70 (DnaK-DnaJ-GrpE) and Hsp100 (ClpA-ClpB-ClpX) in refolding of thermoinactivated luciferase from the marine bacterium Photobacterium fischeri and the terrestrial bacterium Photorhabdus luminescens has been ..
  12. ncbi Lactococcus lactis glyceraldehyde-3-phosphate dehydrogenase gene, gap: further evidence for strongly biased codon usage in glycolytic pathway genes
    M R Cancilla
    Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia
    Microbiology 141:1027-36. 1995
    ..The 3' end of a clpA homologue was identified in the sequence upstream of ORF156. The location of gap on the L...
  13. ncbi An update on the aetiology of orofacial clefts
    F K Wong
    Faculty of Dentisty, The University of Hong Kong, Pokfulam Road, Hong Kong
    Hong Kong Med J 10:331-6. 2004
    ..To review recent data on the aetiology of cleft lip and palate...
  14. ncbi ClpB and HtpG facilitate de novo protein folding in stressed Escherichia coli cells
    J G Thomas
    Department of Chemical Engineering, University of Washington, Seattle 98195, USA
    Mol Microbiol 36:1360-70. 2000
    ..A number of additional proteins, including ClpA, ClpB, HtpG and IbpA/B, act as molecular chaperones in vitro, but their function in cellular protein folding ..
  15. ncbi RNA polymerase of Aquifex pyrophilus: implications for the evolution of the bacterial rpoBC operon and extremely thermophilic bacteria
    H P Klenk
    Georg August Universitat Gottingen, Institut fur Mikrobiologie und Genetik, Grisebachstrabetae 8, 37077 Gottingen, Germany
    J Mol Evol 48:528-41. 1999
    ..RNA polymerase subunits beta and beta' (rpoBC), alanyl-tRNA synthetase (alaS), and subunit A of proteinase Clp (clpA). Enzymatic activity and extreme thermostability of purified A. pyrophilus RNA polymerase were verified...
  16. ncbi Peptidase activity of the Escherichia coli Hsp31 chaperone
    Abderrahim Malki
    Stress Molecules, Institut Jacques Monod, Universite Paris 7, 2 place Jussieu, 75005 Paris, France
    J Biol Chem 280:14420-6. 2005
    ..The ClpA component of the ClpAP protease, the chaperone GroEL, elongation factor EF-Tu, and tryptophanase were all found to ..
  17. ncbi Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26 S proteasome
    M Kessel
    Laboratory of Structural Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 250:587-94. 1995
    ..coli, consists of a proteolytic component, ClpP, in association with an ATP-hydrolyzing, chaperonin-like component, ClpA. To provide a structural basis for understanding the regulation and mechanism of action of Clp protease, we have ..
  18. ncbi Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA)
    M Mukai
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Int J Cancer 81:918-22. 1999
    ..acid (PHYLPA), first isolated from myxoamoebae of Physarum polycephalum, and its synthetic derivatives (cLPA) were tested for their ability to inhibit tumor cell invasion and metastasis...
  19. ncbi Regulated degradation of chromosome replication proteins DnaA and CtrA in Caulobacter crescentus
    Boris Gorbatyuk
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Room 506, Montreal, Quebec, H3A 2B4, Canada
    Mol Microbiol 55:1233-45. 2005
    ..However, a dominant-negative clpX allele that blocks CtrA degradation, even when combined with a clpA null allele, did not decrease DnaA degradation...
  20. pmc Expression of ClpB, an analog of the ATP-dependent protease regulatory subunit in Escherichia coli, is controlled by a heat shock sigma factor (sigma 32)
    M Kitagawa
    Institute for Virus Research, Kyoto University, Japan
    J Bacteriol 173:4247-53. 1991
    ..at least two ATP-dependent proteases, Lon (La) and Clp (Ti), the latter consisting of a regulatory subunit (ClpA) and a proteolytic subunit (ClpP). The gene clpB encoding an analog of ClpA had been found at 57 min on the E...
  21. pmc Contribution of conserved ATP-dependent proteases of Campylobacter jejuni to stress tolerance and virulence
    Marianne Thorup Cohn
    Department of Veterinary Pathobiology, Faculty of Life Sciences, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Appl Environ Microbiol 73:7803-13. 2007
    ..Following inactivation of the ATPase genes clpA and clpX, only the clpX mutant displayed the same heat sensitivity as the clpP mutant, indicating that the ClpXP ..
  22. ncbi Distinctive roles of the two ATP-binding sites in ClpA, the ATPase component of protease Ti in Escherichia coli
    J H Seol
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    J Biol Chem 270:8087-92. 1995
    b>ClpA is the ATPase component of the ATP-dependent protease Ti (Clp) in Escherichia coli and contains two ATP-binding sites...
  23. pmc The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat
    T E Shrader
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 175:4364-74. 1993
    ..The aat gene is located approximately 1 kb from clpA, which encodes a subunit of ATP-dependent protease Clp...
  24. ncbi Molecular properties of ClpAP protease of Escherichia coli: ATP-dependent association of ClpA and clpP
    M R Maurizi
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 37:7778-86. 1998
    The ClpAP protease from Escherichia coli consists of the ATP-binding regulatory component, ClpA (subunit Mr 84 165), and the proteolytic component, ClpP (subunit Mr 21 563)...
  25. ncbi The N-terminal substrate-binding domain of ClpA unfoldase is highly mobile and extends axially from the distal surface of ClpAP protease
    Takashi Ishikawa
    Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD 20892 8025, USA
    J Struct Biol 146:180-8. 2004
    ClpAP is a barrel-like complex consisting of hexameric rings of the ClpA ATPase stacked on the double heptameric ring of ClpP peptidase. ClpA has two AAA+ domains (Dl and D2) and a 153-residue N-domain...
  26. pmc The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice
    Wenjin Liu
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 135:3959-68. 2008
    ..Extensive analyses of palatal gene expression in wild-type and Mn1(-/-) mutant mice identified Tbx22, the mouse homolog of the human X-linked cleft palate gene, as a putative downstream target of Mn1 transcriptional ..
  27. doi Novel two-dimensional DNA gel electrophoresis mapping for characterizing complex bacterial communities in environmental samples
    Guo hua Liu
    Graduate School of Engineering, Yokohama National University, 79 7 Tokiwadai, Hodogaya ku, Yokohama 240 8501, Japan
    J Biosci Bioeng 107:646-51. 2009
    ..a two-dimensional gel electrophoresis (2-DGE) method with a combination of chain-length polymorphism analysis (CLPA) and DGGE analysis, in order to improve the DNA resolution and resolve complex environmental DNA fragments produced ..
  28. ncbi Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli
    D Wojtkowiak
    Department of Molecular Biology, University of Gdansk, Kladki, Poland
    J Biol Chem 268:22609-17. 1993
    ..The 23,000-Da component (LopP) was identified as the previously characterized ClpP protein, known to complex with ClpA to form the ClpAP, an ATP-dependent protease, capable of degrading casein...
  29. pmc The role of the ClpA chaperone in proteolysis by ClpAP
    J R Hoskins
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:12135-40. 1998
    b>ClpA, a member of the Clp/Hsp100 family of ATPases, is a molecular chaperone and, in combination with a proteolytic component ClpP, participates in ATP-dependent proteolysis...
  30. pmc Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development
    Sophie Pantalacci
    Molecular Zoology, Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Universite Lyon 1, CNRS, INRA, Ecole Normale Superieure de Lyon, Lyon, France
    BMC Dev Biol 8:116. 2008
    ..However, rugae could be useful as landmarks to monitor anterior/posterior (A/P) palatal growth, and they provide a simple model of mesenchymal-epithelial structures arranged in a serial pattern...
  31. doi The nanoscale properties of bacterial inclusion bodies and their effect on mammalian cell proliferation
    César Díez-Gil
    Departament de Nanociència Molecular i Materials Orgànics Institut de Ciència de Materials de Barcelona ICMAB CSIC, Bellaterra, 08193 Barcelona, Spain
    Biomaterials 31:5805-12. 2010
    ..In regard to wild type, DnaK(-) and ClpA(-) strains produce inclusion bodies with distinguishable wettability, stiffness and stiffness distribution within ..
  32. pmc Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli
    Mark Lies
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:22918-29. 2008
    ..ClpAP degrades SsrA-tagged proteins slowly even in the absence of SspB, possibly because of interference from ClpA-specific substrates. Lon protease degrades SsrA-tagged proteins at a rate of approximately 0...
  33. doi Autosomal-dominant ankyloglossia and tooth number anomalies
    A C Acevedo
    Oral Care Center for Inherited Diseases, University Hospital of Brasilia, Department of Dentistry, University of Brasilia, Brazil
    J Dent Res 89:128-32. 2010
    ..X-linked cleft palate and is sometimes seen alone due to mutations in the gene encoding the transcription factor TBX22, while knockout of Lgr5 in the mouse results in ankyloglossia...
  34. ncbi Clp P represents a unique family of serine proteases
    M R Maurizi
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Biol Chem 265:12546-52. 1990
    ..Processing of Clp P appears, therefore, to involve an intermolecular autocatalytic cleavage reaction. Since processing of Clp P occurs in clpA- cells, the autoprocessing activity of Clp P is independent of Clp A.
  35. ncbi Mutational analysis demonstrates different functional roles for the two ATP-binding sites in ClpAP protease from Escherichia coli
    S K Singh
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:29537-45. 1994
    b>ClpA, the regulatory subunit of Clp protease from Escherichia coli, has two ATP-binding sites in non-homologous regions of the protein, referred to as domain I and domain II...
  36. ncbi Concurrent chaperone and protease activities of ClpAP and the requirement for the N-terminal ClpA ATP binding site for chaperone activity
    M Pak
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:19316-22. 1999
    b>ClpA, a member of the Clp/Hsp100 family of ATPases, is both an ATP-dependent molecular chaperone and the regulatory component of ClpAP protease...
  37. ncbi ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease
    S K Singh
    Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochemistry 38:14906-15. 1999
    The Escherichia coli ClpA and ClpP proteins form a complex, ClpAP, that catalyzes ATP-dependent degradation of proteins...
  38. ncbi ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes
    Joaquin Ortega
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Struct Biol 146:217-26. 2004
    ..are composed of a single proteolytic component, ClpP, complexed with either of the two related chaperones, ClpA or ClpX...
  39. ncbi The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase
    K M Woo
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    J Biol Chem 267:20429-34. 1992
    The clpB gene in Escherichia coli encodes a heat-shock protein that is a close homolog of the clpA gene product. The latter is the ATPase subunit of the multimeric ATP-dependent protease Ti (Clp) in E...
  40. ncbi Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family
    W Dubiel
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City 84132
    J Biol Chem 267:22699-702. 1992
    ..Subunit 4 also shows weak similarity to ClpA, the ATP-binding subunit of the Escherichia coli protease, Clp.
  41. ncbi Hsp104 is a highly conserved protein with two essential nucleotide-binding sites
    D A Parsell
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Nature 353:270-3. 1991
    ..We report here that hsp104 is a member of the highly conserved ClpA/ClpB protein family first identified in Escherichia coli and that additional heat-inducible members of this family ..
  42. ncbi The two-component, ATP-dependent Clp protease of Escherichia coli. Purification, cloning, and mutational analysis of the ATP-binding component
    Y Katayama
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892
    J Biol Chem 263:15226-36. 1988
    The ATP-binding component (Component II, hereafter referred to as ClpA) of a two-component, ATP-dependent protease from Escherichia coli has been purified to homogeneity. ClpA is a protein with subunit Mr 81,000...
  43. ncbi A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein
    A Mhammedi-Alaoui
    Unité Transposition Bactérienne, Universite Libre de Bruxelles, Rhode St Genese, Belgium
    Mol Microbiol 11:1109-16. 1994
    ..This enzyme is formed by the association between a protease subunit (ClpP) and an ATPase subunit. ClpA, the best characterized of these ATPases, is not required for the degradation of the mutant Mu repressors...
  44. ncbi Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates
    M W Thompson
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:18201-8. 1994
    ..ClpAP protease is an ATP-dependent protease composed of the proteolytic component ClpP and a regulatory ATPase, ClpA. ClpAP protease degraded a variety of peptide bonds in protein and peptide substrates at a slow rate (kcat < or =..
  45. pmc A role for the Clp protease in activating Mu-mediated DNA rearrangements
    J A Shapiro
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    J Bacteriol 175:2625-31. 1993
    ..The clpA::Tn10 mutation, which removes a regulatory subunit of Clp protease, altered the timing of Mu activity in both ..
  46. pmc Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli
    K Damerau
    Nelson Biology Laboratories, Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855 1059
    J Bacteriol 175:53-63. 1993
    ..During starvation, mutants lacking either the ClpA or ClpP subunit of the ATP-dependent Clp protease showed a partial reduction in the degradation of starvation ..
  47. ncbi Requirement of ATP hydrolysis for assembly of ClpA/ClpP complex, the ATP-dependent protease Ti in Escherichia coli
    J H Seol
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    Biochem Biophys Res Commun 217:41-51. 1995
    ..protease Ti (Clp) consists of two distinct components, ClpP containing the serine active sites for proteolysis and ClpA having two ATP-binding sites...
  48. ncbi The cyanobacterium Synechococcus sp. PCC 7942 possesses a close homologue to the chloroplast ClpC protein of higher plants
    A K Clarke
    Department of Plant Physiology, University of Umea, Sweden
    Plant Mol Biol 31:721-30. 1996
    ..Using degenerate PCR primers specific for the two distinct ATP-binding domains characteristic of all ClpA-C proteins, partial sequences homologous to clpC from Synechococcus were also identified in five other ..
  49. pmc Roles of the Escherichia coli small heat shock proteins IbpA and IbpB in thermal stress management: comparison with ClpA, ClpB, and HtpG In vivo
    J G Thomas
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    J Bacteriol 180:5165-72. 1998
    ..compared its growth and viability at high temperatures to those of isogenic cells containing null mutations in the clpA, clpB, or htpG gene. All mutants exhibited growth defects at 46 degrees C, but not at lower temperatures...
  50. pmc ClpB in a cyanobacterium: predicted structure, phylogenetic relationships, and regulation by light and temperature
    M Celerin
    Department of Plant Sciences, University of Western Ontario, London, Ontario, Canada N6A 5B7
    J Bacteriol 180:5173-82. 1998
    ..are not unique to p-ClpB; they are present in all ClpB sequences examined and are absent from the ClpB paralogs ClpA, ClpC, ClpX, and ClpY. Small quantities of a 4...
  51. ncbi Substrate recognition by the ClpA chaperone component of ClpAP protease
    J R Hoskins
    Laboratory of Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:35361-7. 2000
    b>ClpA, a member of the Clp/Hsp100 ATPase family, is a molecular chaperone and regulatory component of ClpAP protease...
  52. ncbi Role of molecular chaperones in inclusion body formation
    M Mar Carrió
    Institut de Biotecnologia i de Biomedicina and Departament de Genètica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
    FEBS Lett 537:215-21. 2003
    ..Although chaperones ClpB, ClpA, IbpA and IbpB also participate in these processes, the impact of the respective null mutations on bacterial ..
  53. pmc luxR homolog avhR in Agrobacterium vitis affects the development of a grape-specific necrosis and a tobacco hypersensitive response
    Guixia Hao
    Department of Plant Pathology, NYSAES, Cornell University, Geneva, NY 14456, USA
    J Bacteriol 187:185-92. 2005
    ..It was determined that avhR and aviR are expressed independently and that neither regulates the expression of a clpA homolog in F2/5.
  54. ncbi The molecular chaperone, ClpA, has a single high affinity peptide binding site per hexamer
    Grzegorz Piszczek
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, MD 20892 8012, USA
    J Biol Chem 280:12221-30. 2005
    ..We studied the binding of short motif-bearing peptides to ClpA, the chaperone component of the ATP-dependent ClpAP protease of Escherichia coli in the presence of ATPgammaS and ..
  55. pmc Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release
    Remco Sprangers
    Department of Biochemistry, University of Toronto, ON, Canada
    Proc Natl Acad Sci U S A 102:16678-83. 2005
    ..ClpP associates with ClpX and ClpA ATPases that unfold and translocate substrates into the protease catalytic chamber through axial pores located at ..
  56. pmc Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop
    Jen Bohon
    Center for Proteomics and Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Structure 16:1157-65. 2008
    Synchrotron X-ray protein footprinting is used to study structural changes upon formation of the ClpA hexamer...
  57. doi ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysis
    Laura D Jennings
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:11536-46. 2008
    ..In the case of the bacterial ATP-dependent protease ClpAP, ATP hydrolysis by the ClpA component has been proposed to be required for processive proteolysis of full-length protein substrates...
  58. doi Tbx22 expressions during palatal development in fetuses with glucocorticoid-/alcohol-induced C57BL/6N cleft palates
    Soung Min Kim
    Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University, Seoul, Korea
    J Craniofac Surg 20:1316-26. 2009
    T-box transcription factor 22 (Tbx22) belongs to the T-box family of transcription factors and was originally found using an in silico approach to identify new genes in the human Xq12-Xq21 region...
  59. doi The function and regulation of TBX22 in avian frontonasal morphogenesis
    Norihisa Higashihori
    Department of Oral Health Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada
    Dev Dyn 239:458-73. 2010
    ..Here we focus on the regulation and function of TBX22, a repressor dynamically expressed in the frontonasal mass...
  60. pmc Binding of the ClpA unfoldase opens the axial gate of ClpP peptidase
    Grégory Effantin
    Laboratory of Structural Biology Research, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:14834-40. 2010
    ..ability of ClpP to process folded protein substrates depends on its being partnered by an AAA+ ATPase/unfoldase, ClpA or ClpX...
  61. pmc Local and global mobility in the ClpA AAA+ chaperone detected by cryo-electron microscopy: functional connotations
    Grégory Effantin
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 18:553-62. 2010
    The ClpA chaperone combines with the ClpP peptidase to perform targeted proteolysis in the bacterial cytoplasm. ClpA monomer has an N-terminal substrate-binding domain and two AAA+ ATPase domains (D1 and D2)...
  62. doi Regulation of Tbx22 during facial and palatal development
    Alisa Fuchs
    Developmental Biology, Institute of Biology 1, Faculty of Biology, University of Freiburg, Freiburg, Germany
    Dev Dyn 239:2860-74. 2010
    Mutations in the gene encoding the T-box transcription factor TBX22 cause X-linked cleft palate and ankyloglossia in humans. Here we show that Tbx22 expression during facial and palatal development is regulated by FGF and BMP signaling...
  63. doi A prenatally ascertained, maternally inherited 14.8 Mb duplication of chromosomal bands Xq13.2-q21.31 associated with multiple congenital abnormalities in a male fetus
    C Sismani
    Department of Cytogenetics and Genomics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Gene 530:138-42. 2013
    ..8 Mb in size and includes fourteen genes: SLC16A2, KIAA2022, ABCB7, ZDHHC15, ATRX, MAGT1, ATP7A, PGK1, TBX22, BRWD3, POU3F4, ZNF711, POF1B and CHM...
  64. pmc Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates
    Izarys Rivera-Rivera
    Department of Biology and
    Proc Natl Acad Sci U S A 111:E3853-9. 2014
    ..ClpS binds the substrate N-degron and assembles into a high-affinity ClpS-substrate-ClpA complex, but how the N-degron is transferred from ClpS to the axial pore of the AAA+ ClpA unfoldase to initiate ..
  65. pmc A translatable predictor of human radiation exposure
    Joseph Lucas
    Information Initiative at Duke, Duke University, Durham, NC, United States of America
    PLoS ONE 9:e107897. 2014
    ..human radiation signature into a rapid and high-throughput chemical ligation-dependent probe amplification assay (CLPA) which was able to discriminate radiation dose levels in a pilot study of ex vivo irradiated human blood and ..
  66. doi Two promoter polymorphisms in TBX22 are associated with the risk of NSCLP in Indian women
    Venkatesh B Gurramkonda
    Departments of aBiomedical Sciences bPlastic Surgery, Sri Ramachandra University, Chennai, Tamil Nadu cGenetic Laboratory, Department of Biochemistry, Sickle Cell Institute Chhattisgarh, Pt JNM Medical College, Raipur, Chhattisgarh, India
    Clin Dysmorphol 24:140-3. 2015
    ..b>TBX22 encodes a T-box containing transcription factor and mutations in this gene are responsible for X-linked cleft ..
  67. pmc Structures, Functions, and Interactions of ClpT1 and ClpT2 in the Clp Protease System of Arabidopsis Chloroplasts
    Jitae Kim
    Department of Plant Biology, Cornell University, Ithaca, New York 14853
    Plant Cell 27:1477-96. 2015
    ..4- and 2.0-Å resolution) and detailed the similarities to the N-domains of bacterial ClpA/C chaperones...
  68. doi Aspergillus fumigatus Cap59-like protein A is involved in α1,3-mannosylation of GPI-anchors
    Anke Tina Krüger
    Department of Cellular Chemistry OE 4330, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Glycobiology 26:30-8. 2016
    ..putative glycosyltransferase involved in capsule formation and virulence, and was thus named Cap59-like protein A (ClpA). Targeted deletion of the clpA gene in A. fumigatus led to absence of α1,3-mannose from mature GPI-anchors...
  69. doi Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo
    Suresh Nimmagadda
    Life Sciences Institute, Department of Oral Health Sciences, University of British Columbia, Vancouver, BC, Canada
    Dev Biol 407:275-88. 2015
    ..Expression of TP63, TBX22, BMP4 and FOXE1, all human clefting genes, were upregulated...
  70. pmc Structural Basis of an N-Degron Adaptor with More Stringent Specificity
    Benjamin J Stein
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Structure 24:232-42. 2016
    ..Here, we demonstrate that both ClpS1 and ClpS2 from A. tumefaciens deliver N-end-rule substrates to ClpA, but ClpS2 has more stringent binding specificity, recognizing only a subset of the canonical bacterial N-end-rule ..
  71. ncbi Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease
    Fusheng Guo
    Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:46743-52. 2002
    Escherichia coli ClpA, an Hsp100/Clp chaperone and an integral component of the ATP-dependent ClpAP protease, participates in regulatory protein degradation and the dissolution and degradation of protein aggregates...
  72. ncbi Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis
    Alexander Herr
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Dev Dyn 226:579-86. 2003
    b>TBX22 belongs to the T-box family of transcription factors and was originally found in an in silico approach designed to identify new genes on the human Xq12-q21 region...
  73. pmc Identification of the protease and the turnover signal responsible for cell cycle-dependent degradation of the Caulobacter FliF motor protein
    Björn Grünenfelder
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    J Bacteriol 186:4960-71. 2004
    ..Cell cycle-dependent turnover of FliF requires an intact clpA gene, suggesting that the ClpAP protease is required for removal of the MS ring protein...
  74. ncbi Roles of the N-domains of the ClpA unfoldase in binding substrate proteins and in stable complex formation with the ClpP protease
    Jörg Hinnerwisch
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 280:40838-44. 2005
    The hexameric cylindrical Hsp100 chaperone ClpA mediates ATP-dependent unfolding and translocation of recognized substrate proteins into the coaxially associated serine protease ClpP...
  75. pmc Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system
    Carr D Vincent
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Mol Microbiol 85:378-91. 2012
    ..Loss of DotL is dependent on ClpA, a regulator of the cytoplasmic protease ClpP...
  76. doi X-linked CHARGE-like Abruzzo-Erickson syndrome and classic cleft palate with ankyloglossia result from TBX22 splicing mutations
    E Pauws
    UCL Institute of Child Health, 30 Guilford Street, London, UK
    Clin Genet 83:352-8. 2013
    X-linked cleft palate (CPX) is caused by mutations in the gene encoding the TBX22 transcription factor and is known to exhibit phenotypic variability, usually involving either a complete, partial or submucous cleft palate, with or ..
  77. doi Mutational, proteomic and metabolomic analysis of a plant growth promoting copper-resistant Pseudomonas spp
    KeFeng Li
    Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931, USA
    FEMS Microbiol Lett 335:140-8. 2012
    ..CSM1, a mutant disrupted in trpA gene (tryptophan synthase alpha subunit), and CSM2, a mutant disrupted in clpA gene (ATP-dependent Clp protease)...
  78. pmc Development of quinoxaline 1, 4-dioxides resistance in Escherichia coli and molecular change under resistance selection
    Wentao Guo
    National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, People s Republic of China
    PLoS ONE 7:e43322. 2012
    ..The 11 cDNAs were related to metabolism or degradation of glycolysis (gpmA and pgi) and proteins (clpX, clpA, pepN and fkpB). The atpADG and ubiB genes were associated with ATP biosynthesis and electron transport chain...
  79. doi Cleavage of the antitoxin of the parD toxin-antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin
    Elizabeth Diago-Navarro
    Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Plasmid 70:78-85. 2013
    ..We further show that this protection is correlated with the inability of the ClpA chaperone to access the Kis antitoxin when in complex with Kid toxin...
  80. pmc E. coli ClpA catalyzed polypeptide translocation is allosterically controlled by the protease ClpP
    Justin M Miller
    Department of Chemistry, The University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294 1240, USA
    J Mol Biol 425:2795-812. 2013
    ..Hexameric ClpA rings associate with one or both faces of the cylindrically shaped tetradecameric ClpP protease...
  81. doi Structural determinants stabilizing the axial channel of ClpP for substrate translocation
    John Alexopoulos
    Department of Biochemistry and Biomedical Sciences and M G DeGroote Institute for Infectious Diseases Research, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S4K1, Canada
    Mol Microbiol 90:167-80. 2013
    ..ADEPs) antibiotics bind to Escherichia coli ClpP mimicking the interactions that the IGL/F loops in ClpA or ClpX ATPases establish with the hydrophobic pockets surrounding the axial pore of the tetradecamer that the ..
  82. ncbi The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate
    S Gottesman
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:7886-93. 1990
    The clpA gene, which codes for the ATP-binding subunit of the ATP-dependent Clp protease of Escherichia coli, has been sequenced...
  83. ncbi Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli
    M R Maurizi
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
    J Biol Chem 265:12536-45. 1990
    ..coli map, close to that for the ATP-dependent Lon protease of E. coli and far from the gene for clpA. Primer extension experiments indicate that transcription initiates immediately upstream of the coding region for ..
  84. ncbi Expression of a putative ATPase suppresses the growth defect of a yeast potassium transport mutant: identification of a mammalian member of the Clp/HSP104 family
    F Périer
    Department of Biological Sciences, University of California, Santa Barbara 93106
    Gene 152:157-63. 1995
    ..domain of SKD3 has 57-64% similarity (30-40% identity) with members of the Clp/HSP104 family, including the ClpA regulatory subunit of the Clp protease and S. cerevisiae heat-shock protein 104...
  85. ncbi The 65-kDa protein derived from the internal translational initiation site of the clpA gene inhibits the ATP-dependent protease Ti in Escherichia coli
    J H Seol
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    J Biol Chem 269:29468-73. 1994
    The clpA gene that encodes the ATPase subunit of the ATP-dependent protease Ti (Clp) in Escherichia coli contains a putative internal translational initiation site...
  86. ncbi Family of the major cold-shock protein, CspA (CS7.4), of Escherichia coli, whose members show a high sequence similarity with the eukaryotic Y-box binding proteins
    S J Lee
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854
    Mol Microbiol 11:833-9. 1994
    ..In addition, a DNA sequence upstream of the clpA gene at 19 min published elsewhere contains an open reading frame for a 74-residue protein with 45% identity to ..
  87. ncbi The 65-kDa protein derived from the internal translational start site of the clpA gene blocks autodegradation of ClpA by the ATP-dependent protease Ti in Escherichia coli
    J H Seol
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, South Korea
    FEBS Lett 377:41-3. 1995
    The ATP-dependent protease Ti consists of two different components: ClpA containing ATP-cleaving sites and ClpP having serine active sites for proteolysis...
  88. ncbi Modulation of intracellular protein degradation by SSB1-SIS1 chaperon system in yeast S. cerevisiae
    M Ohba
    Mitsubishi Kasei Institute of Life Sciences, Machida shi, Tokyo, Japan
    FEBS Lett 409:307-11. 1997
    In prokaryotes, DnaK-DnaJ chaperon is involved in the protein degradation catalyzed by proteases La and ClpA/B complex as shown in E. coli...
  89. ncbi Site-directed mutagenesis of the Cys residues in ClpA, the ATPase component of protease Ti (ClpAP) in Escherichia coli
    J H Seol
    Department of Molecular Biology, College of Natural Sciences, Seoul National University, Korea
    Biol Chem 378:1205-9. 1997
    ..been shown to be inhibited by sulfhydryl blocking agents, such as N-ethylmaleimide (NEM), when preincubated with ClpA but not with ClpP...
  90. pmc The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system
    S Gottesman
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Genes Dev 12:1338-47. 1998
    ..with purified components and required a substrate with a wild-type SsrA tail, the presence of both ClpP and either ClpA or ClpX, and ATP...
  91. ncbi Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP
    R Grimaud
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:12476-81. 1998
    ..Competition studies showed that ClpA may have a slightly higher affinity (approximately 2-fold) for binding to ClpP...
  92. ncbi At sixes and sevens: characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease
    F Beuron
    Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland, 20892, USA
    J Struct Biol 123:248-59. 1998
    ClpAP, a typical energy-dependent protease, consists of a proteolytic component (ClpP) and a chaperone-like ATPase (ClpA)...
  93. pmc Conditional stability of the HemA protein (glutamyl-tRNA reductase) regulates heme biosynthesis in Salmonella typhimurium
    L Wang
    West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Bacteriol 181:1211-9. 1999
    ..coli. Each single mutant shows only a small effect. The ClpA chaperone, but not ClpX, is required for ClpP-dependent HemA turnover...
  94. ncbi ClpP participates in the degradation of misfolded protein in Lactococcus lactis
    D Frees
    Department of Dairy and Food Science, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Mol Microbiol 31:79-87. 1999
    ..In Escherichia coli, ClpP is the proteolytic component of a large complex also containing either the ClpA or the ClpX ATPases...
  95. ncbi Importance of heptameric ring integrity for activity of Escherichia coli ClpP
    M W Thompson
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Eur J Biochem 258:923-8. 1998
    ..Radiation target sizes determined for small peptide hydrolysis, for ClpA activated and nucleotide-activated oligopeptide cleavage, and for ClpA-activated ATP-dependent protein degradation ..
  96. pmc Lon and Clp family proteases and chaperones share homologous substrate-recognition domains
    C K Smith
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:6678-82. 1999
    ..Fragments corresponding to these sequences are stably and independently folded for Lon, ClpA, and ClpY. The corresponding regions from ClpB and ClpX are unstable...
  97. ncbi Identification of clp genes expressed in senescing Arabidopsis leaves
    K Nakabayashi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Plant Cell Physiol 40:504-14. 1999
    ..coli, which consists of two types of subunits, the regulatory subunit with ATPase activity, ClpA, and the catalytic subunit, ClpP...
  98. ncbi Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
    E U Weber-Ban
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 401:90-3. 1999
    ..b>ClpA directs the ATP-dependent degradation of substrate proteins bearing specific sequences, much as the 19S ATPase 'cap'..
  99. ncbi Functional analysis of the ClpATPase ClpA of Brucella suis, and persistence of a knockout mutant in BALB/c mice
    E Ekaza
    Institut National de la Santé et de la Recherche Médicale U 431, Universite Montpellier II, CC 100, Pl E Bataillon, 34095 Montpellier, France
    Microbiology 146:1605-16. 2000
    The protein ClpA belongs to a diverse group of polypeptides named ClpATPases, which are highly conserved, and which include several molecular chaperones...
  100. pmc Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP
    S K Singh
    Laboratory of Cell Biology and Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:8898-903. 2000
    ClpX and ClpA are molecular chaperones that interact with specific proteins and, together with ClpP, activate their ATP-dependent degradation...
  101. ncbi Molecular characterization of a new human T-box gene (TBX22) located in xq21.1 encoding a protein containing a truncated T-domain
    F Laugier-Anfossi
    Inserm Unité 491, Faculté de médecine La Timone, 27 Bd Jean Moulin, 13385 Cedex 5, Marseille, France
    Gene 255:289-96. 2000
    ..We show here that this new gene, called TBX22, is composed of seven exons spanning 8.7 kilobases of genomic DNA in Xq21.1...

Research Grants5

  1. Energetics of Unfolding and Translocation by ClpA
    MELVA JAMES; Fiscal Year: 2007
    ..research proposal is to deconvolute the individual mechanistic steps that describe the interaction of the enzyme ClpA with its protein substrates...
  2. MECHANISM OF ACTION OF THE HSP100 CHAPERONE CLPA
    Arthur Horwich; Fiscal Year: 2006
    ..The site of substrate binding on ClpA will be determined by EM analysis of gold-tagged substrate proteins bound to CIpAP complexes...
  3. STRUCTURE AND FUNCTION OF HSP 100 PROTEINS
    Michal Zolkiewski; Fiscal Year: 2005
    ..Characterize interactions between ClpB95 or ClpB80 and the co-chaperones (DnaK, DnaJ, GrpE). 3. Characterize the role of ClpB95 or ClpB80 and the three co-chaperones in the disaggregation and reactivation of luciferase. ..
  4. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  5. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..