TBX18

Summary

Gene Symbol: TBX18
Description: T-box 18
Alias: CAKUT2, T-box transcription factor TBX18, T-box protein 18
Species: human

Top Publications

  1. doi T-Box Genes in the Kidney and Urinary Tract
    A Kispert
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany Electronic address
    Curr Top Dev Biol 122:245-278. 2017
  2. doi Epithelial-to-mesenchymal transition in epicardium is independent of snail1
    Jesus C Casanova
    Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Genesis 51:32-40. 2013
  3. doi Tbx18 function in epicardial development
    Franziska Greulich
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Str 1, Hannover D 30625, Germany
    Cardiovasc Res 96:476-83. 2012
  4. pmc Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation
    Su yi Tsai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, NY 10029, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, NY 10029, USA
    Dev Biol 385:179-88. 2014
  5. pmc Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney
    Jinshu Xu
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Dev Biol 391:17-31. 2014
  6. pmc Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block
    Yu Feng Hu
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei 112, Taiwan
    Sci Transl Med 6:245ra94. 2014
  7. pmc Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation
    Rachel Sennett
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Exp Dermatol 23:748-50. 2014
  8. pmc Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii
    Nicholas J Hudson
    Computational and Systems Biology, CSIRO Agriculture Flagship, Queensland Bioscience Precinct, Brisbane, Queensland, Australia
    G3 (Bethesda) 4:1825-35. 2014
  9. pmc Generation of the epicardial lineage from human pluripotent stem cells
    Alec D Witty
    1 McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 32:1026-35. 2014
  10. pmc Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration
    Bin Zeng
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People s Republic of China
    Cytotechnology 68:763-70. 2016

Research Grants

  1. Lisa Stubbs; Fiscal Year: 2015
  2. Origins and Patterning of the Epicardium
    NATHALIA SARAH GLICKMAN HOLTZMAN; Fiscal Year: 2010
  3. Hee Cheol Cho; Fiscal Year: 2016
  4. Molecular Mechanisms of PITX2 During Craniofacial Development
    Brad A Amendt; Fiscal Year: 2013
  5. Michael Rendl; Fiscal Year: 2016
  6. Hyaluronan and erbBs regulate cardiac valve formation
    Todd Camenisch; Fiscal Year: 2007

Scientific Experts

  • Andreas Kispert
  • Nicholas J Hudson
  • Todd Camenisch
  • O Yilmaz
  • Henk Pj Buermans
  • Bin Zeng
  • Kalpana Ghoshal
  • Federica Limana
  • J Andrew Gillis
  • Diego Franco
  • D Niedrist
  • V M Christoffels
  • M Rosemann
  • G Begemann
  • Cathy Mendelsohn
  • Mikiko Tanaka
  • Michael Rendl
  • Julia Norden
  • Hee Cheol Cho
  • Franziska Greulich
  • Rachel Sennett
  • Carlos Clavel
  • Henner F Farin
  • Laura Grisanti
  • Rannar Airik
  • Chen Leng Cai
  • Mathilda T M Mommersteeg
  • Antoon F M Moorman
  • Mark Oliver Trowe
  • Amelie Rezza
  • Carsten Rudat
  • Karin Schuster-Gossler
  • Manvendra K Singh
  • Xuguang Nie
  • Brad A Amendt
  • Lisa Stubbs
  • NATHALIA SARAH GLICKMAN HOLTZMAN
  • Caitlin M Braitsch
  • Marianne Petry
  • Nidhi Kapoor
  • Jan Schlueter
  • Thomas Grieskamp
  • Anamika Singh
  • Sindhu Ramesh
  • Thomas Brand
  • Su yi Tsai
  • Tobias Bohnenpoll
  • Xiaoqiang Cai
  • Jinshu Xu
  • Eduardo Marban
  • Pin Xian Xu
  • Markus Bussen
  • Katherine E Yutzey
  • Cornelia Wiese
  • Mei Yang
  • Jörg Männer
  • Toshihiro Nakao
  • Asaf Vivante
  • Regine Häfner
  • Xin Yuan
  • Jonathan A Epstein
  • Alec D Witty
  • Anna Carina Weiss
  • Yu Feng Hu
  • Liming Ma
  • Roland Zemla
  • San Pin Wu
  • Jesus C Casanova
  • Makiko Takeichi
  • Angela Scavone
  • Erin Kaltenbrun
  • Mélanie Paces-Fessy
  • Tamar C Katz
  • Aleksander Sizarov
  • Amy K Wehn
  • Ralf Kist
  • Clifford J Tabin
  • JOSE RIVERA-FELICIANO
  • Angela Torlopp
  • Corrie de Gier-de Vries
  • Bram van Wijk
  • Jason T Lam
  • Michaela Schweizer
  • Susan Skuntz
  • Yinqiu Wang
  • Airon A Wills
  • Radwan Abu-Issa
  • Maike Jahr
  • Nicole M Davis
  • Bin Zhou

Detail Information

Publications90

  1. doi T-Box Genes in the Kidney and Urinary Tract
    A Kispert
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany Electronic address
    Curr Top Dev Biol 122:245-278. 2017
    ..However, this has changed with the finding that mutations in TBX18, a member of a vertebrate-specific subgroup within the Tbx1-subfamily of T-box transcription factor genes, cause ..
  2. doi Epithelial-to-mesenchymal transition in epicardium is independent of snail1
    Jesus C Casanova
    Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Genesis 51:32-40. 2013
    ..To determine the function of Snail1 in epicardial EMT, we deleted Snail1 in the epicardium using Wt1- and Tbx18-Cre drivers...
  3. doi Tbx18 function in epicardial development
    Franziska Greulich
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Str 1, Hannover D 30625, Germany
    Cardiovasc Res 96:476-83. 2012
    ..We aimed to elucidate the functional significance of the conserved epicardial expression of the T-box transcription factor gene Tbx18 using transgenic technology in the mouse.
  4. pmc Wnt/β-catenin signaling in dermal condensates is required for hair follicle formation
    Su yi Tsai
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, NY 10029, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, NY 10029, USA
    Dev Biol 385:179-88. 2014
    ..Here we use the Tbx18(Cre) knockin mouse line to ablate the Wnt-responsive transcription factor β-catenin specifically in these cells ..
  5. pmc Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney
    Jinshu Xu
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Dev Biol 391:17-31. 2014
    b>Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development...
  6. pmc Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block
    Yu Feng Hu
    Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital and National Yang Ming University, Taipei 112, Taiwan
    Sci Transl Med 6:245ra94. 2014
    Somatic reprogramming by reexpression of the embryonic transcription factor T-box 18 (TBX18) converts cardiomyocytes into pacemaker cells...
  7. pmc Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation
    Rachel Sennett
    Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    Exp Dermatol 23:748-50. 2014
    ..receptor in both compartments for early HF formation, we conditionally ablated Cxcr4 with condensate-targeting Tbx18(cre) knock-in and epidermis-targeting Krt14-cre transgenic mice...
  8. pmc Sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat Myotis davidii
    Nicholas J Hudson
    Computational and Systems Biology, CSIRO Agriculture Flagship, Queensland Bioscience Precinct, Brisbane, Queensland, Australia
    G3 (Bethesda) 4:1825-35. 2014
    ..LAMC3, CRX, SOX8, VAX2, HPS1, RHO, PRPH2, and SOX9) and hearing-related (TPRN, TMIE, SLC52A3, OTOF, WFS1, SOD1, TBX18, MAP1A, OTOS, GPX1, and USH1G) machinery in M. davidii but not P. alecto...
  9. pmc Generation of the epicardial lineage from human pluripotent stem cells
    Alec D Witty
    1 McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 32:1026-35. 2014
    ..characteristics and express markers of the epicardial lineage, including the transcription factors WT1 and TBX18 and the retinoic acid-producing enzyme ALDH1A2...
  10. pmc Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration
    Bin Zeng
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People s Republic of China
    Cytotechnology 68:763-70. 2016
    ..marker CD31; vascular smooth muscle marker smooth muscle myosin IgG; cardiac resident stem cells markers IsL1, Tbx18, and Wt1...
  11. doi Fgfr2 is required for the expansion of the early adrenocortical primordium
    Regine Häfner
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Mol Cell Endocrinol 413:168-77. 2015
    ..Here, we show that a Tbx18(cre) line mediates specific recombination in the coelomic epithelium of the anterior urogenital ridge which gives ..
  12. pmc Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development
    Asaf Vivante
    Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer 52621, Israel
    Am J Hum Genet 97:291-301. 2015
    ..1010delG) of T-Box transcription factor 18 (TBX18) in seven affected members of the large kindred...
  13. pmc TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment
    Mei Yang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P R China
    Int J Mol Med 38:1403-1410. 2016
    T-box 18 (TBX18) plays a crucial role in the formation and development of the head of the sinoatrial node...
  14. pmc Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction. An immunohistochemical, histopathological, and clinical comparative study
    Omer Yilmaz
    Department of Pediatric Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey E mail
    Saudi Med J 37:737-43. 2016
    ..To compare pathological samples obtained from cases that underwent surgery for ureteropelvic junction (UPJ) obstruction with samples obtained during autopsies of subjects. ..
  15. pmc Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development
    Franziska Greulich
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 11:e0156787. 2016
    ..The T-box transcription factor gene Tbx18 is specifically expressed in the epicardium of vertebrate embryos...
  16. pmc In Vitro Culture of Epicardial Cells From Mouse Embryonic Heart
    Sindhu Ramesh
    Program in Cardiovascular and Metabolic Disorders, Duke NUS Graduate Medical School
    J Vis Exp . 2016
    ..Epicardial explant cells also retain the expression of epicardial markers (Wt1 and Tbx18)...
  17. pmc Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development
    Anamika Singh
    Program in Cardiovascular and Metabolic Disorders, Duke NUS Medical School Singapore, Singapore 169857, Singapore
    Cell Rep 15:1384-93. 2016
    ..We provide evidence that Yap and Taz control epicardial cell behavior, in part by regulating Tbx18 and Wt1 expression...
  18. ncbi T-box genes and heart development: putting the "T" in heart
    Timothy F Plageman
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, ML7020, Cincinnati, Ohio 45229, USA
    Dev Dyn 232:11-20. 2005
    ..These genes include Tbx1, Tbx2, Tbx3, Tbx5, Tbx18, and Tbx20, all of which exhibit complex temporal spatial regulation in developing cardiac structures...
  19. doi Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer
    Toshihiro Nakao
    Department of Surgery, Tokushima University, Tokushima 770 8503, Japan
    Oncol Rep 34:1961-7. 2015
    ..Comparatively, 193 genes were significantly differentially expressed in the responders in the UFT group. TBX18 upregulation was common to both groups whereas BTNL8, LOC375010, ADH1B, HRASLS2, LOC284232, GCNT3 and ALDH1A2 were ..
  20. doi The impact of sperm-expressed transcription factors on fate-mapping models
    Xin Yuan
    Departments of NephrologyCardiologySecond Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
    Reproduction 150:323-30. 2015
    ..the effect of sperm-expressed Cre on cell type-specific Cre-mediated loxP recombination in fate-mapping models of Tbx18+ progenitor cells...
  21. doi Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium
    Mathilda T M Mommersteeg
    Department of Cell and Developmental Biology, University College London, London, UK
    Circ Res 112:465-75. 2013
    ..The Slit-Roundabout (Robo) signaling pathway has pleiotropic functions during Drosophila heart development. However, its role in mammalian heart development is largely unknown...
  22. ncbi Evidence that mechanisms of fin development evolved in the midline of early vertebrates
    Renata Freitas
    Department of Zoology, University of Florida, PO Box 118525, Gainesville, Florida 32611, USA
    Nature 442:1033-7. 2006
    ..Expression of Hoxd and Tbx18 genes, which specify paired limb positions, also delineates the positions of median fins...
  23. pmc Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease
    Caitlin M Braitsch
    The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, 240 Albert Sabin Way, ML 7020, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 65:108-19. 2013
    During embryonic heart development, the transcription factors Tcf21, Wt1, and Tbx18 regulate activation and differentiation of epicardium-derived cells, including fibroblast lineages...
  24. pmc The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells
    Makiko Takeichi
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e57829. 2013
    ..Here, we show that two transcription factors expressed in the developing epicardium, T-box18 (Tbx18) and Wilms' tumor 1 homolog (Wt1), bi-directionally control the epicardial EMT through their effects on Slug ..
  25. pmc Tbx18 regulates development of the epicardium and coronary vessels
    San Pin Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States Electronic address
    Dev Biol 383:307-20. 2013
    The epicardium and coronary vessels originate from progenitor cells in the proepicardium. Here we show that Tbx18, a T-box family member highly expressed in the proepicardium, controls critical early steps in coronary development...
  26. doi Novel and functional variants within the TBX18 gene promoter in ventricular septal defects
    Liming Ma
    Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Jining Medical University Affiliated Hospital, Jining Medical University, 79 Guhuai Road, Jining, 272029, Shandong, China
    Mol Cell Biochem 382:121-6. 2013
    ..Genetic causes for CHD remain largely unknown. T-box transcription factor 18 (TBX18) gene is expressed in the developing heart, including myocardium of the left ventricle and interventricular septum...
  27. doi Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate
    Tobias Bohnenpoll
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 380:25-36. 2013
    ..to delineate sub-regions within the developing urogenital system that express the T-box transcription factor gene Tbx18. We show that Tbx18 is transiently expressed in the epithelial lining and the subjacent mesenchyme of the ..
  28. pmc Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18
    Nidhi Kapoor
    The Cedars Sinai Heart Institute, Los Angeles, California, USA
    Nat Biotechnol 31:54-62. 2013
    ..Here we demonstrate conversion of rodent cardiomyocytes to SAN cells in vitro and in vivo by expression of Tbx18, a gene critical for early SAN specification. Within days of in vivo Tbx18 transduction, 9...
  29. pmc Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors
    Carlos Clavel
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Cell 23:981-94. 2012
    ..How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18(Cre) to target embryonic DP precursors, we ablate the transcription factor Sox2 early and efficiently, resulting ..
  30. pmc Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation
    Laura Grisanti
    Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA
    J Invest Dermatol 133:344-53. 2013
    ..Here, we report that T-box transcription factor Tbx18 specifically marks dermal papilla (DP) precursor cells during embryonic hair follicle morphogenesis...
  31. doi Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells
    Angela Scavone
    Department of Biosciences, Universita degli Studi di Milano, Milano, Italy
    Circ Res 113:389-98. 2013
    ..So far, such selection has been hampered by the lack of proper markers. CD166 is specifically but transiently expressed in the mouse heart tube and sinus venosus, the prospective SAN...
  32. pmc Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis
    Laura Grisanti
    1 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA 2 Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    J Invest Dermatol 133:2332-9. 2013
    ..We then use the recently characterized Cre-expressing Tbx18 knock-in line to conditionally ablate Enpp2 in embryonic DP precursors...
  33. pmc A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression
    Erin Kaltenbrun
    Departments of Biology and Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, United States
    J Proteome Res 12:5395-409. 2013
    ..Remodeling and Deacetylase (NuRD) complex, the chromatin remodeling ATPases RUVBL1/RUVBL2, and the T-box repressor Tbx18. We determined that the interaction with TLE corepressors is mediated via an eh1 binding motif in Tbx20...
  34. pmc Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice
    Julia Norden
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS ONE 7:e45100. 2012
    ..We found by histological analyses that both in Tbx18- and Wt1-deficient mice the pleural and pericardial cavities communicate due to a partial absence of the ..
  35. doi Wnt/Ctnnb1 signaling and the mesenchymal precursor pools of the heart
    Julia Norden
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Trends Cardiovasc Med 22:118-22. 2012
    ..Finally, Tbx18(+) precursors are added at the posterior cardiac pole after the chambers have been formed to generate the ..
  36. pmc Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart
    Caitlin M Braitsch
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, ML 7020, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    Dev Biol 368:345-57. 2012
    ..of the epicardium and EPDCs in chicken and mouse embryonic hearts, and the transcription factors WT1, NFATC1, and Tbx18 are expressed in overlapping and distinct subsets of Pod1-expressing cells...
  37. doi Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis
    Mélanie Paces-Fessy
    Inserm Unité 969, 9 quai St Bernard Bat C, 75005 Paris, France
    Hum Mol Genet 21:3143-55. 2012
    ..muscle differentiation around the ureter associated with a local down-regulation in transcript levels of Bmp4 and Tbx18, two key regulators involved in ureter smooth muscle formation, thus explaining, at least in part, megaureters...
  38. pmc Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells
    Tamar C Katz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 22:639-50. 2012
    ..In contrast to previously fate-mapped Tbx18/WT-1-expressing cells that give rise to vascular smooth muscle, Scx- and Sema3D-expressing proepicardial cells ..
  39. doi Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme
    Rannar Airik
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Hum Mol Genet 19:4918-29. 2010
    ..Furthermore, Sox9 genetically interacts with the T-box transcription factor 18 gene (Tbx18) during ureter development at two levels--as a downstream mediator of Tbx18 function and in a converging pathway...
  40. pmc Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart
    Bin Zeng
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China
    J Biomed Sci 18:67. 2011
    ..The present study therefore aimed to examine the the expression of Tbx18 and Wt1 in embryonic heart and to identify whether Tbx18 and Wt1 themselves expressed in the cardiomyocyte.
  41. doi Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation
    Julia Norden
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 109:e42-50. 2011
    ..The signaling pathways that regulate the most posterior elongation of the heart, that is, the addition of the systemic venous return from a Tbx18(+) precursor population, have remained elusive.
  42. doi Molecular analysis of patterning of conduction tissues in the developing human heart
    Aleksander Sizarov
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Arrhythm Electrophysiol 4:532-42. 2011
    ..To date, lack of gene expression data for the developing human conduction system has precluded valid extrapolations from experimental studies to the human situation...
  43. doi Mechanisms of T-box gene function in the developing heart
    Franziska Greulich
    Institute for Molecular Biology, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Cardiovasc Res 91:212-22. 2011
    ..Tbx1 and Tbx18 ensure elongation of the cardiac tube at the anterior and posterior pole, respectively...
  44. pmc Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
    Dev Biol 352:141-51. 2011
    ..Instead, the UB elongates within Tbx18- and Bmp4-expressing mesenchyme...
  45. doi Notch signaling regulates smooth muscle differentiation of epicardium-derived cells
    Thomas Grieskamp
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Circ Res 108:813-23. 2011
    ....
  46. pmc Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes
    Nidhi Kapoor
    Cedars Sinai Heart Institute, Los Angeles, California 90048, USA
    J Biol Chem 286:14073-9. 2011
    ..Mesenchymal precursor cells expressing Tbx18 give rise to the heart's pacemaker, the sinoatrial node (SAN)...
  47. ncbi Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
    Diego Franco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
    Dev Biol 294:366-75. 2006
    ..The T-box transcription factor encoding gene, Tbx18, is expressed in the left ventricle and left side of the developing IVS, providing additional support for the ..
  48. doi Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 102:1340-9. 2008
    ..5 and 15.5, ectopically expressed genes for connexin (Cx)43, atrial natriuretic factor (Nppa), Tbx18, and Tbx20 in the atrioventricular bundle and proximal bundle branches...
  49. doi Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes
    Mark Oliver Trowe
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Development 135:1725-34. 2008
    ..We demonstrate that differentiation of otic fibrocytes requires the T-box transcription factor gene Tbx18. Tbx18 expression during inner ear development is restricted to the sub-region of otic mesenchyme that is fated to ..
  50. ncbi Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:183-92. 2008
    ..Rapid animal growth also induced strong expression of the embryonic epicardial markers raldh2 (aldh1a2) and tbx18 in adult epicardial tissue...
  51. ncbi Induction of proepicardial marker gene expression by the liver bud
    Yasuo Ishii
    University of California San Francisco, Cardiovascular Research Institute, Box 2711, Rock Hall Room 384D, 1550 4th Street, San Francisco, CA 94158 2324, USA
    Development 134:3627-37. 2007
    ..Here, we show that the expression of proepicardial marker genes - Wt1, capsulin (epicardin, pod1, Tcf21) and Tbx18, can be induced in naïve mesothelial cells by the liver bud, both in vitro and in vivo...
  52. pmc Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis
    Oscar L Volger
    Department of Medical Biochemistry, Room K1 114, Academic Medical Center, University of Amsterdam, Meibergdreef 15, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 171:326-37. 2007
    ..value of corresponding endothelial protein expression between early (fractalkine/CX3CL1, IP10/CCL10, TBX18) or advanced (BAX, NFKB2) stages of atherosclerosis and versus their plaque-free controls...
  53. ncbi Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors
    Henner F Farin
    Institute for Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 282:25748-59. 2007
    Tbox18 (Tbx18) and Tbox15 (Tbx15) encode a closely related pair of vertebrate-specific T-box (Tbx) transcription factors...
  54. ncbi Morphological and molecular left-right asymmetries in the development of the proepicardium: a comparative analysis on mouse and chick embryos
    Inga Schulte
    Department of Anatomy and Embryology, Georg August University of Gottingen, Germany
    Dev Dyn 236:684-95. 2007
    ..The left anlage remains in a rudimentary state. The expression patterns of PE marker genes (Tbx18, Wt1) correspond to the morphological data, being bilateral in the mouse and unilateral in the chick...
  55. ncbi Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
    Yasmin Babaie
    Roslin Institute, Department of Gene Function and Development, Roslin, Midlothian, United Kingdom
    Stem Cells 25:500-10. 2007
    ..either positively (NANOG, SOX2, REX1, LEFTB, LEFTA/EBAF DPPA4, THY1, and TDGF1) or negatively (CDX2, EOMES, BMP4, TBX18, Brachyury [T], DKK1, HLX1, GATA6, ID2, and DLX5), as well as targets for the OCT4-associated stem cell regulators ..
  56. ncbi Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18
    Vincent M Christoffels
    Department of Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 98:1555-63. 2006
    ..In contrast, the sinus horns express the T-box transcription factor gene Tbx18. Mice deficient for Tbx18 fail to form sinus horns from the pericardial mesenchyme and have defective caval veins, ..
  57. ncbi T-genes and limb bud development
    Mary King
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Med Genet A 140:1407-13. 2006
    ..Recent studies have shown that T, Tbx2, Tbx3, Tbx4, Tbx5, Tbx15, and Tbx18 are all expressed in the limb buds, and many have developmental functions...
  58. doi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to ..
  59. ncbi BMP is an important regulator of proepicardial identity in the chick embryo
    Jan Schlueter
    Cell and Developmental Biology, Theodor Boveri Institute, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Dev Biol 295:546-58. 2006
    ..In order to study PE development in chick embryos, we have analyzed the expression pattern of the marker genes Tbx18, Wt1, and Cfc. During PE induction, the three marker genes displayed a left-right asymmetric expression pattern...
  60. pmc Tbx18 regulates the development of the ureteral mesenchyme
    Rannar Airik
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Clin Invest 116:663-74. 2006
    ..The gene encoding the T-box transcription factor Tbx18 was expressed in undifferentiated mesenchymal cells surrounding the distal ureter stalk...
  61. pmc Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts
    Cathy Mendelsohn
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Clin Invest 116:635-7. 2006
    ..A study by Airik et al. in this issue of the JCI reveals that T-box 18 (Tbx18), a transcription factor selectively expressed in ureteral mesenchyme, regulates smooth muscle differentiation by ..
  62. ncbi Transcriptome analysis of the murine forelimb and hindlimb autopod
    Siming Shou
    Research Division, Shriners Hospital for Children, Portland, OR 97239, USA
    Dev Dyn 234:74-89. 2005
    ..05) were detected between forelimb and hindlimb tissues including 38 new transcripts such as Rdh10, Frzb, Tbx18, and Hip that exhibit differential limb expression...
  63. ncbi Analysis of TBX18 expression in chick embryos
    Bénédicte Haenig
    Abteilung Molekulare Embryologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Dev Genes Evol 214:407-11. 2004
    ..Here, we report the expression of the TBX18 gene during chick development...
  64. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..Here, we demonstrate that maintenance of AP-somite polarity is mediated by the T-box transcription factor Tbx18. Mice deficient for Tbx18 show expansion of pedicles with transverse processes and proximal ribs, elements derived ..
  65. ncbi Tbx18 and boundary formation in chick somite and wing development
    Mikiko Tanaka
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    Dev Biol 268:470-80. 2004
    The chicken Tbx gene, Tbx18, is expressed in lateral plate mesoderm, limb, and developing somites. Here we show that Tbx18 is expressed transiently in axial mesenchyme during somite segmentation...
  66. ncbi Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma
    M Rosemann
    Institute of Pathology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Carcinogenesis 24:371-6. 2003
    ..These studies have allowed us to identify Tbx18, a member of the T-box transcriptional regulator gene family, as a candidate gene...
  67. ncbi Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development
    Gerrit Begemann
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield School of Medicine, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mech Dev 114:137-41. 2002
    ..We have cloned the paralogous genes tbx15 and tbx18 in zebrafish and have characterised their expression in detail...
  68. ncbi Cloning and expression analysis of the mouse T-box gene Tbx18
    F Kraus
    Max Planck Institut fur Immunbiologie, Abt Molekulare Embryologie, Stubeweg 51, 79108 Freiburg, Germany
    Mech Dev 100:83-6. 2001
    ..In this report, we describe the cloning and expression analysis of the novel mouse T-box gene Tbx18. During development expression is most prominent in the proepicardial organ and in the epicardium of the heart...
  69. pmc Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton
    Susan Skuntz
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3706, USA
    Dev Biol 332:383-95. 2009
    ..and they are associated with alterations in the expression of at least three transcription factor genes, Tbx18, Uncx, and Bapx1...
  70. ncbi Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19
    C H Yi
    School of Clinical Laboratory Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH
    Genomics 55:10-20. 1999
    ..We have identified four new human members of the T-box gene family, EOMES, TBX6, TBX18, and TBX19, and these genes have been mapped to different chromosomal regions by radiation hybrid mapping...
  71. doi Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm
    Amy K Wehn
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Dev Biol 347:404-13. 2010
    ..The vertebral column, ribs, and appendicular skeleton were all affected in these embryos, which resembled Tbx18 and Tbx15 null embryos...
  72. doi Role of fibroblast growth factor signaling during proepicardium formation in the chick embryo
    Angela Torlopp
    Cell and Developmental Biology, University of Wurzburg, Germany
    Dev Dyn 239:2393-403. 2010
    ..In contrast, expression of Tbx18, Wt1, or Tbx5 were unaffected by FGF inhibition...
  73. pmc HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e10338. 2010
    ..The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer...
  74. doi Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse
    Mark Oliver Trowe
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 342:51-62. 2010
    ..Tissue-specific inactivation of Sox9 in the periotic mesenchyme using a Tbx18(Cre) mouse line results in arrest of early chondrogenesis and consequently, in a lack of cochlear otic capsule ..
  75. doi The sinus venosus progenitors separate and diversify from the first and second heart fields early in development
    Mathilda T M Mommersteeg
    Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 87:92-101. 2010
    ..However, after the establishment of the heart tube, Tbx18(+) progenitors were proposed to form the Tbx18(+)/Nkx2-5(-) sinus venosus and proepicardium...
  76. pmc SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation
    Xuguang Nie
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Development 137:755-65. 2010
    ..We show that Six1 and Tbx18 genetically interact to synergistically regulate SMC development and ureter function and that their gene products ..
  77. doi Myocardial infarction induces embryonic reprogramming of epicardial c-kit(+) cells: role of the pericardial fluid
    Federica Limana
    Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    J Mol Cell Cardiol 48:609-18. 2010
    ..Interestingly, WT1, Tbx18 and RALDH2, notably involved in epicardial embryonic development, were markedly up-regulated...
  78. doi The evolution of gnathostome development: Insight from chondrichthyan embryology
    J Andrew Gillis
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, USA
    Genesis 47:825-41. 2009
    ..to pattern the endoskeleton of gnathostome paired fins and chondrichthyan gill rays, while expression patterns of Tbx18 and HoxD family members are shared by gnathostome paired fins and chondrichthyan median fins...
  79. pmc Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways
    Bram van Wijk
    Academic Medical Center, Department Anatomy and Embryology, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Circ Res 105:431-41. 2009
    ..Not much is known about the relation between the myocardial and epicardial lineage during development, whereas insights into these embryonic mechanisms could facilitate the design of future regenerative strategies...
  80. pmc Comprehensive gene-expression survey identifies wif1 as a modulator of cardiomyocyte differentiation
    Henk P J Buermans
    Human and Clinical Genetics Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 5:e15504. 2010
    ..In ovo exposure of the HH12 chicken embryonic heart to Wif1 increases the Tbx18-positive cardiac progenitor pool. These data indicate that Wif1 enhances cardiomyogenesis.
  81. pmc Cre/lox recombination in the lower urinary tract
    Yinqiu Wang
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Genesis 47:409-13. 2009
    b>Tbx18 is a T-Box transcription factor that has specific expression and indispensible function in the lower urinary tract...
  82. doi Multipotent progenitor cells in regenerative cardiovascular medicine
    Jason T Lam
    Klinikum rechts der Isar and German Heart Center, Technical University of Munich, I Medical Clinic, Molecular Cardiology, Ismaninger Strasse 22, 81675 Munich, Germany
    Pediatr Cardiol 30:690-8. 2009
    ..arise from multipotent cardiovascular progenitors expressing the transcription factors Mesp1, Isl1, Nkx2-5, and Tbx18. Recent identification of stem/progenitor cells of embryonic origin with intrinsic competence to differentiate ..
  83. doi Tbx18 and the fate of epicardial progenitors
    Vincent M Christoffels
    Department of Anatomy and Embryology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2 108, 1105 AZ Amsterdam, The Netherlands
    Nature 458:E8-9; discussion E9-10. 2009
    ..Cai et al. suggest that Tbx18-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ..
  84. pmc 4q32-q35 and 6q16-q22 are valuable candidate regions for split hand/foot malformation
    Dunja Niedrist
    Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
    Eur J Hum Genet 17:1086-91. 2009
    ..We now show further evidence. In the proposed regions, there are interesting candidate genes such as, on 4q: HAND2, FGF2, LEF1 and BMPR1B; on 5q: MSX2, FLT4, PTX1 and PDLIM7; and on 6q: SNX3, GJA1, HEY2 and Tbx18.
  85. doi Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3
    Cornelia Wiese
    Center for Heart Failure Research, Academic Medical Centre, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands
    Circ Res 104:388-97. 2009
    ..Using genetic lineage analysis and explant assays, we identified T-box transcription factor Tbx18-expressing mesenchymal progenitors in the inflow tract region that differentiate into pacemaker myocardium to form ..
  86. doi Development of the proepicardium in Xenopus laevis
    Maike Jahr
    Department of Anatomy and Embryology, Georg August University of Gottingen, Germany
    Dev Dyn 237:3088-96. 2008
    ..Corresponding to the morphological data, the PE marker gene Tbx18 is expressed only on the right sinus horn suggesting a right-sided origin of the PE...
  87. pmc Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Biochem Biophys Res Commun 375:450-3. 2008
    ..Both Nkx2-5- and Isl1-expressing progenitors contributed to the proepicardium and expressed Wt1 and Tbx18, markers of proepicardial progenitor cells...
  88. doi T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm
    Henner F Farin
    Institute for Molecular Biology, Medizinische Hochschule Hannover, OE5250, Carl Neuberg Strasse 1, Hannover, Germany
    J Biol Chem 283:25372-80. 2008
    ..1 and Tbx18, acting in the posterior and anterior somite compartment, respectively...
  89. pmc The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery
    Nicole M Davis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 15:134-45. 2008
    ..are instructed by a set of transcription factors: Pitx2 and Isl1 specifically expressed on the left side, and Tbx18 expressed on the right, regulated downstream of the secreted protein Nodal which is present exclusively on the ..

Research Grants6

  1. Lisa Stubbs; Fiscal Year: 2015
    ..Our preliminary studies identify the T-box protein, Tbx18, as a vital member of this prostate regulatory network, active in the urogenital mesenchyme from the earliest ..
  2. Origins and Patterning of the Epicardium
    NATHALIA SARAH GLICKMAN HOLTZMAN; Fiscal Year: 2010
    ..of the zebrafish epicardium by position, morphology, and gene expression;demonstrate the requirements for tbx5 and tbx18, transcription factors expressed in the epicardial precursors in directing epicardial morphogenesis and maturation ..
  3. Hee Cheol Cho; Fiscal Year: 2016
    ..b>Tbx18, in particular, has been shown to be indispensable for the specification of the SA node during development...
  4. Molecular Mechanisms of PITX2 During Craniofacial Development
    Brad A Amendt; Fiscal Year: 2013
    ..differentially regulates gene expression through specific protein-protein interactions with T-box factors Tbx1 and Tbx18 and the LIM homeodomain factors Islet-1 and Lhx6...
  5. Michael Rendl; Fiscal Year: 2016
    ..In this proposal, we will utilize genetic drivers of DP genes Tbx18 and Sox2 to test the hypothesis that DP cells establish a niche for HF stem cells...
  6. Hyaluronan and erbBs regulate cardiac valve formation
    Todd Camenisch; Fiscal Year: 2007
    ..unreadable] [unreadable]..