TAS2R7

Summary

Gene Symbol: TAS2R7
Description: taste 2 receptor member 7
Alias: T2R7, TRB4, taste receptor type 2 member 7, taste receptor, family B, member 4, taste receptor, type 2, member 7
Species: human

Top Publications

  1. doi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
  2. pmc The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors
    Jasbir D Upadhyaya
    Department of Oral Biology, and Manitoba Chemosensory Biology MCSB Research group, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada
    PLoS ONE 11:e0156347. 2016
  3. doi Next generation semiconductor based sequencing of bitter taste receptor genes in different pig populations and association analysis using a selective DNA pool-seq approach
    A Ribani
    Department of Agricultural and Food Sciences DISTAL, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy
    Anim Genet 48:97-102. 2017
  4. ncbi The Odorant (R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46
    Barbara Suess
    Chair of Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Straße 34, D 85354 Freising Weihenstephan, Germany
    J Agric Food Chem . 2016
  5. ncbi Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations
    Yuan Su
    Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, People s Republic of
    J Genet 95:675-81. 2016
  6. doi Different phenolic compounds activate distinct human bitter taste receptors
    Susana Soares
    Department of Chemistry, University of Porto, Porto, Portugal
    J Agric Food Chem 61:1525-33. 2013
  7. doi Assessment of the presence of chemosensing receptors based on bitter and fat taste in the gastrointestinal tract of young pig
    M Colombo
    University of Bologna, DIPROVAL, 42123 Reggio Emilia, Italy
    J Anim Sci 90:128-30. 2012
  8. ncbi T2Rs function as bitter taste receptors
    J Chandrashekar
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 100:703-11. 2000
  9. ncbi A family of candidate taste receptors in human and mouse
    H Matsunami
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:601-4. 2000
  10. ncbi A plethora of taste receptors
    S C Kinnamon
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    Neuron 25:507-10. 2000

Scientific Experts

  • Wolfgang Meyerhof
  • S C Kinnamon
  • A Ribani
  • Jasbir D Upadhyaya
  • Yuan Su
  • Barbara Suess
  • P Trevisi
  • P Bosi
  • Susana Soares
  • M Colombo
  • Boris Le Nevé
  • G Schiavo
  • E Scotti
  • F Bertolini
  • L Fontanesi
  • V J Utzeri
  • S Dall'Olio
  • Zhongxian Xu
  • Thomas Hofmann
  • Qing Zhu
  • Binlong Chen
  • Uma Gaur
  • Yaodong Hu
  • Diyan Li
  • Anne Brockhoff
  • Raja Chakraborty
  • Yan Wang
  • Feroz A Shaik
  • Huadong Yin
  • Rajinder P Bhullar
  • Prashen Chelikani
  • Nan Wu
  • Appalaraju Jaggupilli
  • Sophie Thalmann
  • Victor de Freitas
  • Nuno Mateus
  • Susann Kohl
  • G Gandolfi
  • J Chandrashekar
  • Martin Foltz
  • Robin Gouka
  • H Matsunami
  • Hannelore Daniel
  • L Feng
  • K L Mueller
  • E Adler
  • M A Hoon
  • L B Buck
  • C S Zuker
  • W Guo
  • N J Ryba
  • J P Montmayeur

Detail Information

Publications11

  1. doi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
    ..Conversely, though 63 bitter substances activated only 1-3 receptors, 19 compounds stimulated up to 15 hTAS2Rs. Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs...
  2. pmc The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors
    Jasbir D Upadhyaya
    Department of Oral Biology, and Manitoba Chemosensory Biology MCSB Research group, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada
    PLoS ONE 11:e0156347. 2016
    ..This phenomenon of chaperone activity of quinine was also observed for T2R7, T2R10, T2R39 and T2R46...
  3. doi Next generation semiconductor based sequencing of bitter taste receptor genes in different pig populations and association analysis using a selective DNA pool-seq approach
    A Ribani
    Department of Agricultural and Food Sciences DISTAL, Division of Animal Sciences, University of Bologna, Viale Fanin 46, 40127, Bologna, Italy
    Anim Genet 48:97-102. 2017
    ..generation semiconductor based target resequencing, we analysed nine porcine TAS2R genes (TAS2R1, TAS2R3, TAS2R4, TAS2R7, TAS2R9, TAS2R10, TAS2R16, TAS2R38 and TAS2R39) to identify variability and, at the same time, estimate single ..
  4. ncbi The Odorant (R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46
    Barbara Suess
    Chair of Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Straße 34, D 85354 Freising Weihenstephan, Germany
    J Agric Food Chem . 2016
    ..Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed (R)-citronellal to ..
  5. ncbi Genetic diversity of bitter taste receptor gene family in Sichuan domestic and Tibetan chicken populations
    Yuan Su
    Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, People s Republic of
    J Genet 95:675-81. 2016
    ..Previous research had revealed that chicken has only three bitter taste receptor genes (Tas2r1, Tas2r2 and Tas2r7)...
  6. doi Different phenolic compounds activate distinct human bitter taste receptors
    Susana Soares
    Department of Chemistry, University of Porto, Porto, Portugal
    J Agric Food Chem 61:1525-33. 2013
    ..In contrast, malvidin-3-glucoside and procyanidin trimer stimulated only one receptor, TAS2R7 and TAS2R5, respectively...
  7. doi Assessment of the presence of chemosensing receptors based on bitter and fat taste in the gastrointestinal tract of young pig
    M Colombo
    University of Bologna, DIPROVAL, 42123 Reggio Emilia, Italy
    J Anim Sci 90:128-30. 2012
    ..For 7 genes for bitter taste (TAS2R1, TAS2R3, TAS2R7, TAS2R9, TAS2R10, TAS2R16, and TAS2R38) and for 3 genes for fat taste (GPR40, GPR43, and GPR120), a full homology ..
  8. ncbi T2Rs function as bitter taste receptors
    J Chandrashekar
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 100:703-11. 2000
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds...
  9. ncbi A family of candidate taste receptors in human and mouse
    H Matsunami
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:601-4. 2000
    ..Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans...
  10. ncbi A plethora of taste receptors
    S C Kinnamon
    Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523, USA
    Neuron 25:507-10. 2000
  11. doi The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells
    Boris Le Nevé
    Technical University of Munich, Freising Weihenstephan, Germany
    Am J Physiol Gastrointest Liver Physiol 299:G1368-75. 2010
    ..g.-12 could activate human bitter receptors. The steroid glycoside activated selectively TAS2R7 and TAS2R14, both heterologously expressed in HEK 293 cells...