TAS2R38

Summary

Gene Symbol: TAS2R38
Description: taste 2 receptor member 38
Alias: PTC, T2R38, T2R61, taste receptor type 2 member 38, PTC bitter taste receptor, taste receptor type 2 member 61, taste receptor, type 2, member 38
Species: human

Top Publications

  1. doi Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy
    Beverly J Tepper
    Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    Obesity (Silver Spring) 16:2289-95. 2008
  2. pmc Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Am J Hum Genet 74:637-46. 2004
  3. doi Supertasting and PROP bitterness depends on more than the TAS2R38 gene
    John E Hayes
    Department of Nutritional Sciences, College of Agriculture and Natural Resources, University of Connecticut, Storrs, CT 06269 2101, USA
    Chem Senses 33:255-65. 2008
  4. ncbi Variability in a taste-receptor gene determines whether we taste toxins in food
    Mari A Sandell
    Curr Biol 16:R792-4. 2006
  5. ncbi Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
  6. ncbi Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene
    D A Prodi
    Shardna Life Sciences, Cagliari, Italy
    Chem Senses 29:697-702. 2004
  7. pmc Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children
    Nicholas J Timpson
    Department of Social Medicine, Bristol University, Bristol, UK
    BMC Genet 8:51. 2007
  8. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
  9. ncbi Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Nicotine Tob Res 7:853-8. 2005
  10. pmc The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:4278-85. 2010

Research Grants

  1. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
  2. DNA methylation markers for early detection of thyroid cancer
    Josena K Stephen; Fiscal Year: 2013
  3. The RET/PTC3 Oncogene: Antigenic and Inflammatory Properties
    LAURENCE CRANE EISENLOHR; Fiscal Year: 2013
  4. Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention
    Mohammad Athar; Fiscal Year: 2010
  5. Hedgehog Signal Transduction Across the Cell Membrane
    Lawrence Lum; Fiscal Year: 2010
  6. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
  7. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
  8. MICHAEL MINGZHAO XING; Fiscal Year: 2015
  9. Yuri E Nikiforov; Fiscal Year: 2016
  10. James A Fagin; Fiscal Year: 2016

Detail Information

Publications420 found, 100 shown here

  1. doi Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy
    Beverly J Tepper
    Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA
    Obesity (Silver Spring) 16:2289-95. 2008
    Variation in the bitter-taste receptor gene, TAS2R38 confers the ability to taste 6-n-propylthiouracil (PROP)...
  2. pmc Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
    Stephen Wooding
    Department of Human Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Am J Hum Genet 74:637-46. 2004
    The ability to taste phenylthiocarbamide (PTC) is a classic phenotype that has long been known to vary in human populations...
  3. doi Supertasting and PROP bitterness depends on more than the TAS2R38 gene
    John E Hayes
    Department of Nutritional Sciences, College of Agriculture and Natural Resources, University of Connecticut, Storrs, CT 06269 2101, USA
    Chem Senses 33:255-65. 2008
    Polymorphisms in the TAS2R38 gene provide insight to phenotypes long associated 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness...
  4. ncbi Variability in a taste-receptor gene determines whether we taste toxins in food
    Mari A Sandell
    Curr Biol 16:R792-4. 2006
  5. ncbi Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin
    Jen C Wang
    Washington University in St Louis, MO 63110, USA
    Alcohol Clin Exp Res 31:209-15. 2007
    ..genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP)...
  6. ncbi Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene
    D A Prodi
    Shardna Life Sciences, Cagliari, Italy
    Chem Senses 29:697-702. 2004
    ..This region contains the TAS2R38 gene that encodes a member of the TAS2R bitter taste receptor family...
  7. pmc Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children
    Nicholas J Timpson
    Department of Social Medicine, Bristol University, Bristol, UK
    BMC Genet 8:51. 2007
    ..Our aim was to examine the relationships between bitter tasting ability and variation at the TAS2R38 locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ..
  8. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
    ..If the ability of TAS2R16 to detect substances with common molecular properties is typical of the bitter receptor family, it may explain how a few receptors permit the perception of numerous bitter substances...
  9. ncbi Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Nicotine Tob Res 7:853-8. 2005
    Phenotypic evidence indicates that the ability to taste the bitter compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) may protect against cigarette smoking...
  10. pmc The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:4278-85. 2010
    ..For PROP, the peak association was within TAS2R38 (rs713598, A49P, P = 1.6 × 10(-104)), which accounted for 45.9% of the trait variance...
  11. pmc Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children
    Kathleen L Keller
    Department of Research Medicine and the New York Obesity Research Center, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 18:1194-200. 2010
    ..between PROP status and sex on BMI z-score, and (ii) to determine if sex also interacts with variations in TAS2R38 (phenylthiocarbamide (PTC) genotype) to influence weight status in 4-6 year olds...
  12. doi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
    ..Conversely, though 63 bitter substances activated only 1-3 receptors, 19 compounds stimulated up to 15 hTAS2Rs. Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs...
  13. pmc Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa
    Michael C Campbell
    Department of Genetics, University of Pennsylvania, PA, USA
    Mol Biol Evol 29:1141-53. 2012
    ..genetic basis and evolutionary history of bitter taste sensitivity, we sequenced a 2,975 bp region encompassing TAS2R38, a bitter taste receptor gene, in 611 Africans from 57 populations in West Central and East Africa with diverse ..
  14. doi Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype
    Carla Calo
    Department of Experimental Biology, Section of Anthropology, Monserrato, CA, I 09042, Italy
    Physiol Behav 104:1065-71. 2011
    ..This variation is associated with polymorphisms in the bitter receptor gene TAS2R38 and the taste-bud trophic factor gustin gene...
  15. pmc Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin
    Maura Carrai
    Department of Biology, University of Pisa, Pisa, Italy
    PLoS ONE 6:e20464. 2011
    ..By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk ..
  16. doi Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans
    J E Mangold
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville VA 22911, USA
    J Med Genet 45:578-82. 2008
    ..Although previous psychophysical studies suggest that taste status plays a role in nicotine dependence (ND), genetic evidence is lacking...
  17. ncbi Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Science 299:1221-5. 2003
    The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstrated complex inheritance for this trait...
  18. pmc Genetic and environmental determinants of bitter perception and sweet preferences
    Julie A Mennella
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA
    Pediatrics 115:e216-22. 2005
    ..The present study tests the hypothesis that genetic variations in the newly discovered TAS2R38 taste gene as well as cultural differences are associated with differences in sensitivity to the bitter taste of ..
  19. ncbi TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study
    Nic J Timpson
    Department of Social Medicine, University of Bristol, United Kingdom
    Am J Clin Nutr 81:1005-11. 2005
    ..Recent observations have implicated 2 common haplotypes of TAS2R38 in the determination of bitter compound-tasting ability.
  20. pmc Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women
    Cedrick D Dotson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Appetite 54:93-9. 2010
    ..The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and ..
  21. ncbi Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
    Hum Genet 112:567-72. 2003
    The ability to taste phenylthiocarbamide (PTC) shows complex inheritance in humans...
  22. ncbi Genetics of individual differences in bitter taste perception: lessons from the PTC gene
    U K Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA
    Clin Genet 67:275-80. 2005
    The ability or inability to taste the compound phenylthiocarbamide (PTC) is a classic inherited trait in humans and has been the subject of genetic and anthropological studies for over 70 years...
  23. ncbi [Interventional radiology in the palliative treatment of pancreatic cancer]
    E Mazza
    Dipartimento di Fisiopatologia Clinica, , Italia
    Tumori 85:S54-9. 1999
    ..In 44 patients Wallstents were placed during a single PTC session time ("one step" technique). In 21 cases (11%) peri-procedural complications occurred...
  24. ncbi Temperature, eluent flow-rate and column effects on the retention and quantitation properties of phenylthiocarbamyl derivatives of amino acids in reversed-phase high-performance liquid chromatography
    A Vasanits
    Institute of Inorganic and Analytical Chemistry, , Budapest, Hungary
    J Chromatogr A 832:109-22. 1999
    The separation and identification possibilities of 27 PTC-amino acids (with particular attention to those present in apples in free forms), are reported on seven RP columns such as, Nucleosil, 3 and 5 microns: 150(+20 guard) x 4...
  25. ncbi Secondary hyperparathyroidism: evidence for an association with papillary thyroid cancer
    M L Klyachkin
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536-0084, USA
    Am Surg 67:397-9. 2001
    ..We report three patients in whom invasive papillary thyroid carcinoma (PTC) was diagnosed before (one case) or at the time of (two cases) parathyroidectomy for SHPT...
  26. ncbi Determination of amino acids in the foods by reversed-phase high-performance liquid chromatography with a new precolumn derivative, butylthiocarbamyl amino acid, compared to the conventional phenylthiocarbamyl derivatives and ion-exchange chromatography
    K L Woo
    Department of Food Engineering, Kyungnam University, Masan, South Korea
    J Chromatogr A 740:31-40. 1996
    ..The sensitivity of BTC-amino acid was similar to phenylthiocarbamyl (PTC) amino acid. The detection limit in both derivatives was about 3.9 pmol at 0...
  27. ncbi Taste sensitivities to PROP and PTC vary independently in mice
    Theodore M Nelson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201 1509, USA
    Chem Senses 28:695-704. 2003
    ..to the chemically similar, bitter-tasting compounds 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC) are heritable and strongly correlated, suggesting a common genetic basis...
  28. ncbi A combination of chemical derivatisation and improved bioinformatic tools optimises protein identification for proteomics
    F L Brancia
    Michael Barber Centre for Mass Spectrometry, UMIST, Manchester, UK
    Electrophoresis 22:552-9. 2001
    ..Second, an Edman-type phenylthiocarbamoyl (PTC) modification is carried out on the N-terminal amino acid...
  29. pmc Isolation of a new broad-host-range IncQ-like plasmid, pTC-F14, from the acidophilic bacterium Acidithiobacillus caldus and analysis of the plasmid replicon
    M N Gardner
    Department of Microbiology, University of Stellenbosch, Matieland 7602, South Africa
    J Bacteriol 183:3303-9. 2001
    ..caldus cells revealed two plasmids of approximately 14 and 45 kb. The 14-kb plasmid, designated pTC-F14, was cloned and shown by replacement of the cloning vector with a kanamycin resistance gene to be capable of ..
  30. doi Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa
    K Guerin
    Vision Science, University of California, Berkeley, CA 94720, USA
    Exp Eye Res 87:197-207. 2008
    ..administered aminoglycosides as a therapy for retinal degeneration resulting from premature termination codon (PTC) mutations...
  31. ncbi Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification
    Shamila Mauiyyedi
    Pathology Service, Immunopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Soc Nephrol 13:779-87. 2002
    ..C4d deposition in peritubular capillaries (PTC) of renal allografts has been proposed as a useful marker for AHR...
  32. ncbi Sensitive assay to detect thyroid stimulating antibody (TSAb) in the presence of thyroid stimulation blocking antibody (TSBAb) in serum
    Y Ochi
    Research Institute for Production Development, Sakyo, Kyoto, Japan
    Horm Metab Res 33:115-20. 2001
    ..We recently demonstrated that polyethylene glycol (PEG) augments TSAb activity in porcine thyroid cells (PTC) assay...
  33. ncbi [Diagnostic imaging of hilar cholangiocarcinoma: preoperative evaluation of ERC, MRC and PTC in comparison with histopathology]
    B Romaneehsen
    Klinik und Poliklinik für Radiologie, Johannes Gutenberg Universitat Mainz
    Rofo 176:1750-8. 2004
    ..of endoscopic retrograde cholangiography (ERC), magnetic resonance cholangiography (MRC), and percutaneous resonance cholangiography (PTC) with the tumor extent of the surgical specimen in patients with hilar cholangiocarcinoma (hilCC).
  34. ncbi Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancer
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
    Int J Cancer 122:785-90. 2008
    ..Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex...
  35. ncbi Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor
    R M Ruggeri
    Section of Endocrinology, Clinical Experimental Department of Medicine and Pharmacology, University of Messina School of Medicine, Messina, Italy
    J Endocrinol Invest 25:959-66. 2002
    ..to 2 variants (4/4 microfollicular toxic and 2/2 hyalinizing trabecular); 9/30 (30%) papillary thyroid cancers (PTC), all belonging to the conventional variant...
  36. pmc Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis
    Patricia J McLaughlin
    Department of Neural and Behavioral Sciences, The Milton S, Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA
    BMC Cancer 9:369. 2009
    ..Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers...
  37. ncbi Neuromuscular blockade can be assessed accelerographically over the vastus medialis muscle in patients positioned prone
    Yuhji Saitoh
    Department of Anesthesiology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima City, Fukushima 960 1295, Japan
    Can J Anaesth 50:342-7. 2003
    ..To study accelerographic monitoring of neuromuscular blockade over the vastus medialis muscle in anesthetized patients in the prone position...
  38. ncbi Expression of CTNS alleles: subcellular localization and aminoglycoside correction in vitro
    A Helip-Wooley
    Hayward Human Genetics Center, Tulane University School of Medicine, 1430 Tulane Avenue SL 31, New Orleans, Louisiana 70112, USA
    Mol Genet Metab 75:128-33. 2002
    ..Homozygosity for a nonsense mutation in CTNS (753G -->A), encoding a premature termination codon (PTC) at amino acid 138 (W138X), results in nephropathic cystinosis...
  39. doi The post-tetanic count during vecuronium-induced neuromuscular blockade in halothane-anaesthetized dogs
    Farshid Sarrafzadeh-Rezaei
    Department of Clinical Sciences, University of Urmia, Western Azerbaijan, Iran
    Vet Anaesth Analg 36:246-54. 2009
    To evaluate the post-tetanic count (PTC) for predicting the return of reversible neuromuscular blockade at the n. facialis-m. nasolabialis (nF-mNL) and n. ulnaris-mm...
  40. pmc Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake
    Valerie B Duffy
    School of Allied Health, University of Connecticut, 358 Mansfield Rd, Box U 101, Storrs, CT 06269 2101, USA
    Alcohol Clin Exp Res 28:1629-37. 2004
    ..g., bitterness) and more positive (eg, sweetness) sensations from alcohol. We determined whether the TAS2R38 gene at 7q36 predicted PROP bitterness, alcohol sensation and use.
  41. ncbi Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats
    Eun Sook Y Lee
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Neurotoxicology 26:27-38. 2005
    Lysophosphatidylcholine (lyso-PTC), a secondary product of S-adenosylmethionine (SAM)-dependent phosphatidylethanolamine (PTE) methylation, is a potent cytotoxin and might be involved in the pathogenesis of Parkinson's disease (PD)...
  42. ncbi The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    C Wetmore
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Res 60:2239-46. 2000
    ..a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh), contribute to tumor formation in several tissues...
  43. ncbi Total thyroidectomy is the recommended treatment for all Papillary Thyroid Carcinoma (PTC)
    J Santini
    Dept. of Otolaryngology, Head and Neck Surgery, C.H.U. Pasteur, Nice, France
    Acta Otorhinolaryngol Belg 53:161-4. 1999
    ..The major unresolved debate concerning the ideal surgical management of PTC focuses on the extent of thyroidectomy...
  44. pmc The gene cluster for agmatine catabolism of Enterococcus faecalis: study of recombinant putrescine transcarbamylase and agmatine deiminase and a snapshot of agmatine deiminase catalyzing its reaction
    José L Llácer
    Instituto de Biomedicina de Valencia IBV CSIC, C Jaime Roig 11, 46010 Valencia, Spain
    J Bacteriol 189:1254-65. 2007
    ..makes ATP from agmatine in three steps catalyzed by agmatine deiminase (AgDI), putrescine transcarbamylase (PTC), and carbamate kinase (CK). An antiporter exchanges putrescine for agmatine. We have cloned the E...
  45. ncbi Nicorandil accelerates recovery of neuromuscular block caused by vecuronium
    Y Saitoh
    Department of Anesthesiology, Fukushima Medical University School of Medicine, Japan
    Can J Anaesth 48:28-33. 2001
    ..To examine the effect of nicorandil, a K ATP channel agonist, on neuromuscular block caused by vecuronium in patients anesthetized with nitrous oxide, oxygen, isoflurane, and fentanyl...
  46. doi A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma
    Elly S W Ngan
    Department of Surgery, University of Hong Kong, Pokfulam, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong, SAR, China
    J Natl Cancer Inst 101:162-75. 2009
    The genetic factors that determine the risk of papillary thyroid carcinoma (PTC) among patients with multinodular goiter (MNG) remain undefined...
  47. ncbi Gene rearrangements in radiation-induced thyroid carcinogenesis
    H M Rabes
    Institute of Pathology, University of Munich, Munich, Germany
    Med Pediatr Oncol 36:574-82. 2001
    ..Recent observations in large cohorts of children and young adults who developed papillary thyroid carcinomas (PTC) related to accidental radiation exposure after the Chernobyl reactor accident revealed typical genetic aberrations ..
  48. ncbi Ret oncogene protein expression in papillary thyroid carcinoma and related lesions
    K T Mai
    Department of Laboratory Medicine, Ottawa Hospital, Ontario, Canada
    Tumori 87:166-72. 2001
    Activation of Ret oncogenes, particularly Ret/PTC, has been identified in papillary thyroid carcinoma (PTC)...
  49. ncbi Identifying dead regions in the cochlea: psychophysical tuning curves and tone detection in threshold-equalizing noise
    Van Summers
    Army Audiology and Speech Center, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
    Ear Hear 24:133-42. 2003
    ..The experiments reported here examine the consistency of TEN and PTC tasks in identifying dead regions in listeners with high-frequency hearing loss.
  50. doi Long-term results of percutaneous bilioenteric anastomotic stricture treatment in liver-transplanted children
    Airton Mota Moreira
    Radiology Institute, Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil
    Cardiovasc Intervent Radiol 33:90-6. 2010
    ..purpose of this study was to evaluate the mid- and long-term results of percutaneous transhepatic cholangiography (PTC) and biliary drainage in children with isolated bilioenteric anastomotic stenosis (BAS) after pediatric liver ..
  51. pmc Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas
    Gaetano Magro
    Department F G Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy
    Am J Pathol 163:183-96. 2003
    Previous studies have suggested that surface components of papillary thyroid carcinoma (PTC) cells may be aberrantly glycanated, but the precise nature of these molecules has not been unveiled nor documented to be of clinical relevance...
  52. ncbi Immunohistochemical and genetic analysis of mandibular cysts in heterozygous ptc knockout mice
    Kenji Kimi
    Department of Oral Medicine and Bioregulation, Tohoku University Graduate School of Dentistry, Sendai, Japan
    J Oral Pathol Med 32:108-13. 2003
    Alterations of human patched (ptc) homolog have been proven to be responsible for basal cell nevus syndrome (BCNS)...
  53. ncbi Papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma: treatment outcome and prognosis
    S Basu
    Radiation Medicine Centre, Tata Memorial Hospital, Bombay, India
    J Laryngol Otol 120:338-42. 2006
    Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is one of the extremely rare variants of papillary thyroid carcinoma...
  54. ncbi Monitoring of neuromuscular block after administration of vecuronium in patients with diabetes mellitus
    Y Saitoh
    Department of Anesthesiology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima City, Fukushima 960 1295, Japan
    Br J Anaesth 90:480-6. 2003
    ....
  55. ncbi New breakpoints in both the H4 and RET genes create a variant of PTC-1 in a post-Chernobyl papillary thyroid carcinoma
    R Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Clin Endocrinol (Oxf) 53:131-6. 2000
    Two main types of RET/PTC oncogene, named RET/PTC-1 and 3, occur in papillary thyroid carcinomas especially in those from Belarus children after the Chernobyl nuclear accident...
  56. doi Diagnostic utility of CD56 immunohistochemistry in papillary carcinoma of the thyroid
    Dina El Demellawy
    University of Northern Ontario School of Medicine, Thunder Bay Regional Health Sciences Centre, Department of Pathology and Laboratory Medicine, Suite 1720, 980 Oliver Road, Thunder Bay, Ontario P7J1A7, Canada
    Pathol Res Pract 205:303-9. 2009
    Diagnosis of papillary thyroid carcinoma (PTC), in many but not all cases, is an easily achievable diagnosis with almost minimal interobservable variability between pathologists...
  57. ncbi Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
    Shuiying Hu
    Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Cancer 119:2322-9. 2006
    The role of aberrant tumor suppressor gene methylation in the aggressiveness of papillary thyroid cancer (PTC) has not been documented...
  58. ncbi Intranuclear cytoplasmic inclusions and nuclear grooves in fine needle aspiration smears of papillary thyroid carcinoma and its variants: advantage of the count under an oil-immersion objective over a high-power objective
    Dilip K Das
    Department of Pathology, Faculty of Medicine, and Health Sciences Computer Center, Kuwait University, Safat, Kuwait
    Anal Quant Cytol Histol 27:83-94. 2005
    To determine the advantage of examining fine needle aspiration (FNA) smears of papillary thyroid carcinoma (PTC) under a 100 x oil-immersion objective, which is capable of optically sectioning the cells.
  59. ncbi Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study
    Veli Matti Wasenius
    Department of Oncology, Helsinki University Central Hospital, FIN 00029 Helsinki, Finland
    Clin Cancer Res 9:68-75. 2003
    To screen and validate the global gene expression in papillary thyroid carcinoma (PTC) using cDNA expression arrays and immunohistochemistry on tumor tissue microarrays in an attempt to find genes that may be of importance in the ..
  60. doi Two patients with highly aggressive macrofollicular variant of papillary thyroid carcinoma
    Monica G Cardenas
    Division of Endocrinology, Diabetes and Bone and Mineral Disorders, Henry Ford Hospital, Detroit, Michigan 48202 3141, USA
    Thyroid 19:413-6. 2009
    The macrofollicular variant of papillary thyroid carcinoma (MFV-PTC) is an unusual type of thyroid carcinoma with histological features that can be confused with nodular goiter or follicular adenoma...
  61. ncbi Analysis of percutaneous transhepatic cholangioscopy-related complications and the risk factors for those complications
    H C Oh
    Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Songpa Gu, Seoul, Korea
    Endoscopy 39:731-6. 2007
    Percutaneous transhepatic cholangioscopy (PTC) is being increasingly used for patients with biliary tract diseases...
  62. ncbi Investigation of V600E BRAF mutation in papillary thyroid carcinoma in the Polish population
    Ewa Brzezianska
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Polish Mother s Memorial Hospital Research Institute, Rzgowska Street No 281 289, 93 338 Lodz, Poland
    Neuro Endocrinol Lett 28:351-9. 2007
    Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland. The high incidence of RET/PTC and Trk rearrangements or point mutations in RAS and c-MET oncogenes are the genetic hallmarks of PTC...
  63. pmc Effectiveness of bed rest after mild traumatic brain injury: a randomised trial of no versus six days of bed rest
    J R de Kruijk
    Department of Neurology, University Hospital Maastricht, The Netherlands
    J Neurol Neurosurg Psychiatry 73:167-72. 2002
    ..after mild traumatic brain injury (MTBI) is determined largely by the appearance of post-traumatic complaints (PTC). The prevalence of PTC after six months is estimated to be between 20 and 80%...
  64. pmc ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells
    Karen Denning
    Department of Histopathology, University of Dublin, Trinity College, Dublin, Ireland
    Mol Cancer 7:44. 2008
    ..T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid disease (AITD) and thyroid neoplasia...
  65. ncbi Algorithm for safe and effective reoperative thyroid bed surgery for recurrent/persistent papillary thyroid carcinoma
    Tarik Y Farrag
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Head Neck 29:1069-74. 2007
    The aim of this study was to review our experience with reoperative thyroid bed surgery (RTBS) for recurrent/persistent papillary thyroid cancer (PTC), and present an algorithm for safe and effective RTBS.
  66. ncbi High prevalence of c-RET expression in papillary thyroid carcinomas from the Korean population
    Sihoon Lee
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Sinchon dong, Seodaemun gu, Seoul, Korea
    Thyroid 15:259-66. 2005
    ..There are several conflicting reports on the influences of RET expression and RET/PTC rearrangements on the clinical outcome of thyroid cancers...
  67. doi Association of the T1799A BRAF mutation with tumor extrathyroidal invasion, higher peripheral platelet counts, and over-expression of platelet-derived growth factor-B in papillary thyroid cancer
    Yangang Wang
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Endocr Relat Cancer 15:183-90. 2008
    ..and platelet-derived growth factor (PDGF) with respect to clinicopathological outcomes of papillary thyroid cancer (PTC) may play a role in PTC pathogenesis but remains undefined...
  68. doi Peritubular capillary C4d staining in late acute renal allograft rejection--is it relevant?
    Anjali A Satoskar
    Department of Pathology, The Ohio State University, Columbus, OH, USA
    Clin Transplant 22:61-7. 2008
    In the early post-transplant period, renal allograft rejection with diffuse peritubular capillary (PTC) C4d deposition predicts poor graft survival...
  69. ncbi The ulinastatin-induced effect on neuromuscular block caused by vecuronium
    Y Saitoh
    Department of Anesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan
    Anesth Analg 89:1565-9. 1999
    ..Sixty adult patients were randomly divided into four groups of 15 patients each: ulinastatin-posttetanic count (U-PTC), ulinastatin-train-of-four (U-TOF), control-posttetanic count (C-PTC) or control-train-of-four (C-TOF) group...
  70. pmc ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout
    R Michael Tuttle
    Endocrinology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Thyroid 18:839-46. 2008
    ..While previous studies have demonstrated a high prevalence of ret/papillary thyroid cancer (PTC) activation in cohorts of patients developing thyroid nodules after childhood exposure to ionizing radiation, no ..
  71. ncbi High prevalence of RET, RAS, and ERK expression in Hashimoto's thyroiditis and in papillary thyroid carcinoma in the Korean population
    Dae young Kang
    Department of Pathology and Cancer Research Institute, Chungnam National University College of Medicine, Daejeon, Korea
    Thyroid 17:1031-8. 2007
    The RET/PTC-RAS-BRAF cascade is associated with papillary thyroid carcinoma (PTC).
  72. ncbi Incidence trends for papillary thyroid carcinoma and their correlation with thyroid surgery and thyroid fine-needle aspirate cytology
    John R Burgess
    Department of Endocrinology, Royal Hobart Hospital, University of Tasmania, Tasmania
    Thyroid 16:47-53. 2006
    Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy. The reported incidence of PTC has more than doubled in many countries during the past half century...
  73. ncbi Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas
    Ana Rita Marques
    Centro de Investigação de Patobiologia Molecular, Instituto Portugues de Oncologia Francisco Gentil, 1099 023 Lisboa Codex, Portugal
    J Clin Endocrinol Metab 87:3947-52. 2002
    ..in follicular thyroid carcinomas (FTC), but not in follicular thyroid adenomas (FTA), papillary thyroid carcinomas (PTC), or multinodular hyperplasias...
  74. ncbi Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat
    Melvin R Hayden
    Department of Internal Medicine, University of Missouri, Columbia, USA
    Am J Physiol Renal Physiol 292:F861-7. 2007
    ..The proximal tubule cell (PTC) is responsible for the reabsorption of 5-8 g of glomerular filtered albumin each day...
  75. ncbi Relationship of sodium/iodide symporter expression with I131 whole body scan uptake between primary and metastatic lymph node papillary thyroid carcinomas
    S J Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon Sacred Heart Hospital, Gyo Dong 153, Chuncheon si, Kangwon Do 200 704, Republic of Korea
    J Endocrinol Invest 30:28-34. 2007
    ..study was to evaluate total and membranous Na+/I- symporter (NIS) expressions in papillary thyroid carcinoma (PTC) tissue, correlation of NIS expression between primary and metastatic lymph node (LN) PTC tissues, and relationship ..
  76. ncbi Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited
    E Kebebew
    Department of Surgery, S343, University of California, San Francisco, School of Medicine, 513 Parnassus Street, San Francisco, California 94143 0470, USA
    World J Surg 25:632-7. 2001
    The effect of chronic lymphocytic thyroiditis (CLT) on the behavior of papillary thyroid cancer (PTC) remains unclear...
  77. doi Genetic alterations in papillary thyroid carcinoma and hashimoto thyroiditis: An analysis of hOGG1 loss of heterozygosity
    Mark C Royer
    Department of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, USA
    Arch Otolaryngol Head Neck Surg 136:240-2. 2010
    ..relationship between hOGG1 loss of heterozygosity (LOH), Hashimoto thyroiditis (HT), and papillary thyroid cancer (PTC)...
  78. doi Predictive factors for ipsilateral or contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma
    Bon Seok Koo
    Department of Otolaryngology Head and Neck Surgery, Cancer Research Institute, Chungnam National University College of Medicine, Daejeon, Korea
    Ann Surg 249:840-4. 2009
    To investigate the incidence and the risk factors for occult ipsilateral or contralateral central neck lymph node (LN)metastasis in patients with unilateral papillary thyroid carcinoma (PTC) and a clinically negative neck.
  79. ncbi The changing incidence and spectrum of thyroid carcinoma in Tasmania (1978-1998) during a transition from iodine sufficiency to iodine deficiency
    J R Burgess
    Department of Diabetes and Endocrine Services, Royal Hobart Hospital, Australia
    J Clin Endocrinol Metab 85:1513-7. 2000
    ..Histopathological and demographic data were reviewed. A total of 289 cases of TC were identified. Papillary TC (PTC), follicular TC, medullary TC, and other species accounted for 62%, 23%, 4%, and 11% of cases, respectively...
  80. ncbi Increased expression of vascular endothelial growth factor C in papillary thyroid carcinoma correlates with cervical lymph node metastases
    Xiao Min Yu
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    Clin Cancer Res 11:8063-9. 2005
    ..showing that vascular endothelial growth factor C (VEGF-C) mRNA is up-regulated in papillary thyroid carcinoma (PTC), the role of VEGF-C in lymph node metastasis is still unclear...
  81. ncbi Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies
    Francesco Latrofa
    Department of Endocrinology, University Hospital of Pisa, Via Cisanello 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:591-6. 2008
    ..of Tg binding by human monoclonal TgAb in autoimmune thyroid diseases (AITD) [Hashimoto's thyroiditis (HT) and Graves' disease (GD)] but not in non-AITD [nontoxic multinodular goiter (NTMG) and papillary thyroid carcinoma (PTC)].
  82. ncbi Impact of surgical treatment on outcomes for papillary thyroid cancer
    Karl Y Bilimoria
    Department of Surgery, Feinberg School of Medicine, Northwestern University, 201 East Huron Street, Galter 10 105, Chicago, IL 60611, USA
    Adv Surg 42:1-12. 2008
    ..on data from SEER and the NCDB, the contemporary dominant practice pattern in the United States for patients with PTC > or =1.0 cm is a total or near-total thyroidectomy...
  83. doi L-thyroxine-treated patients with nodular goiter have lower serum TSH and lower frequency of papillary thyroid cancer: results of a cross-sectional study on 27 914 patients
    E Fiore
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    Endocr Relat Cancer 17:231-9. 2010
    The risk of papillary thyroid cancer (PTC) is related to serum TSH, and the development of thyroid autonomy by reducing TSH levels decreases the frequency of PTC in patients with nodular goiter...
  84. ncbi Continuous negative abdominal pressure device to treat pseudotumor cerebri
    H J Sugerman
    Department of Surgery, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
    Int J Obes Relat Metab Disord 25:486-90. 2001
    To study the effects of an externally applied negative abdominal pressure device designed to lower the effects of intra-abdominal pressure (IAP) on headaches and pulsatile tinnitus in severely obese women with pseudotumor cerebri (PTC).
  85. ncbi CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study
    Manju L Prasad
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Thyroid 14:169-75. 2004
    Molecular markers of papillary thyroid carcinoma (PTC) are relatively unknown. Recently, the CITED1 gene was reported to be greatly upregulated in PTC relative to normal thyroid...
  86. doi Local variability in PTC thermistor grain boundary structures
    C Leach
    Materials Science Centre, School of Materials, University of Manchester, Manchester M1 7HS, UK
    Scanning 30:339-46. 2008
    ..These results suggest that electrically active grain boundaries with different structures coexist within the thermistor...
  87. ncbi Growing thyroid nodules with benign histology and RET rearrangement
    Vincenzo Marotta
    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita Federico II, Napoli, Italy
    Endocr J 57:1081-7. 2010
    ..we performed molecular diagnostic tests that revealed the absence of BRAF(V600E) and the presence of RET/PTC-1 in one nodule and RET/PTC-3 in the two others...
  88. pmc Annual Average Changes in Adult Obesity as a Risk Factor for Papillary Thyroid Cancer: A Large-Scale Case-Control Study
    Yunji Hwang
    From the Department of Preventive Medicine YH, DK, SKP, Seoul National University College of Medicine Department of Biomedical Science YH, DK, SKP, Seoul National University Graduate School Cancer Research Institute YH, KEL, DK, SKP, Seoul National University College of Medicine Department of Surgery KEL, S JK, HK, Seoul National University Hospital and College of Medicine Division of Surgery KEL, Thyroid Center, Seoul National University Cancer Hospital Department of Internal Medicine YJP, DJP, Seoul National University College of Medicine Department of Family Medicine BC, h cc, Health Promotion Center for Cancer Survivor, Seoul National University Hospital, Seoul and Advanced Institutes of Convergence Technology BC, h cc, Seoul National University, Suwon Si, Gyeonggi Do, Korea
    Medicine (Baltimore) 95:e2893. 2016
    We evaluated the association between weight change in middle-aged adults and papillary thyroid cancer (PTC) based on a large-scale case-control study. Our study included data from 1551 PTC patients (19.3% men and 80...
  89. doi Signaling pathways in follicular cell-derived thyroid carcinomas (review)
    Mírian Romitti
    Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Oncol 42:19-28. 2013
    ..Point mutations in the BRAF or RAS genes or rearranged in transformation (RET)/papillary thyroid carcinoma (PTC) gene rearrangements are observed in approximately 70% of papillary cancer cases...
  90. ncbi Selective alkane C-H-bond functionalizations utilizing oxidative single-electron transfer and organocatalysis
    Peter R Schreiner
    Institut fur Organische Chemie, Justus Liebig University, Heinrich Buff Ring 58, D 35392 Giessen, Germany
    Chem Rec 3:247-57. 2004
    ..utilizing carbon-centered (relatively stable) radicals generated under organocatalytic (phase-transfer catalysis, PTC) conditions are presented as valuable alternatives to other radical-chain alkane functionalizations...
  91. pmc Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult Mammalian brain
    Lynette A Desouza
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Endocrinology 152:1989-2000. 2011
    ..hormone regulates expression of the key developmental morphogen sonic hedgehog (Shh), and its coreceptors patched (Ptc) and smoothened (Smo), in the early embryonic and adult forebrain...
  92. ncbi Extent of routine central lymph node dissection with small papillary thyroid carcinoma
    Yong Sang Lee
    Department of Surgery, Yonsei University Medical College, Seoul, Republic of Korea
    World J Surg 31:1954-9. 2007
    The indications for and extent of routine lymph node dissection in patients with papillary thyroid carcinoma (PTC) are unclear...
  93. pmc Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype
    Ryan J Ellis
    Endocrine Oncology Branch R J E, M B, D P, N N, M H, L Z, E K, Genetics Branch Y W, H S S, S D, D C E, P S M, and Laboratory of Pathology M J M, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 and Perelman School of Medicine R J E, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Clin Endocrinol Metab 99:E329-37. 2014
    Aberrant DNA methylation is known to be a major factor in oncogenesis and cancer progression, but effects of methylation in papillary thyroid cancer (PTC) are not well defined.
  94. doi Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
    Zheming Lu
    Laboratory of Genetics, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, China
    J Pathol 239:72-83. 2016
    Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma (MPTC)...
  95. doi Urokinase receptor, MMP-1 and MMP-9 are markers to differentiate prognosis, adenoma and carcinoma in thyroid malignancies
    Daniel Buergy
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Mannheim Faculty, University of Heidelberg, and DKFZ Heidelberg, Mannheim, Germany
    Int J Cancer 125:894-901. 2009
    ..from 69 prospectively followed patients with thyroid carcinomas (papillary, medullary, follicular and anaplastic, PTC, MTC, FTC and ATC) or follicular adenomas...
  96. ncbi Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway
    K E Lewis
    Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK
    Development 126:2397-407. 1999
    ..In contrast, Shh expression itself is unaffected. Here we examine expression of patched (ptc), which encodes a component of the Shh receptor, and is probably itself a direct target of Shh signalling, to ..
  97. doi Diagnostic and prognostic value of immunocytochemistry and BRAF mutation analysis on liquid-based biopsies of thyroid neoplasms suspicious for carcinoma
    Esther Diana Rossi
    Division of Anatomic Pathology and Histology, Agostino Gemelli School of Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur J Endocrinol 168:853-9. 2013
    ..lesions and BRAF activating mutations have been identified in a significant amount of papillary thyroid carcinomas (PTC)...
  98. ncbi Is level V dissection necessary for low-risk patients with papillary thyroid cancer metastasis in lateral neck levels II, III, and IV
    Wen Bin Yu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Head and Neck, Peking University Cancer Hospital and Institute, Beijing, China
    Asian Pac J Cancer Prev 13:4619-22. 2012
    Whether it is beneficial to dissect level V in papillary thyroid cancer (PTC) patients with positive lateral neck lymph nodes at levels II-IV is still controversial, especially for low risk cases...
  99. pmc Inhibition of patched-1 prevents injury-induced neointimal hyperplasia
    Eileen M Redmond
    Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
    Arterioscler Thromb Vasc Biol 33:1960-4. 2013
    To determine the role of patched receptor (Ptc)-1 in mediating pulsatile flow-induced changes in vascular smooth muscle cell growth and vascular remodeling.
  100. pmc A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition
    Jerneja Tomsic
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
    Sci Rep 5:10566. 2015
    Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals...
  101. doi BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas
    Valentina Sancisi
    Laboratory of Molecular Biology, Department of Oncology, Arcispedale S Maria Nuova, Azienda Ospedaliera Instituto di Ricovero e Cura a Carattere Scientifico, Viale Risorgimento 80, 42123 Reggio Emilia, Italy
    J Clin Endocrinol Metab 97:E1745-9. 2012
    ..However, controversy exists on the consistency of these data, and very little is known about the relationship between this genetic alteration and the tendency of papillary thyroid carcinoma (PTC) to develop metastasis at distant sites.

Research Grants72

  1. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..We expect this research to lead to improved control of PTC with regard to early disease detection and better disease management and, thus, to enhance public health services.
  2. DNA methylation markers for early detection of thyroid cancer
    Josena K Stephen; Fiscal Year: 2013
    ..and malignant thyroid nodules, to detect early TC, to improve discrimination of adenoma, papillary thyroid cancer (PTC), and FTC so as to delineate thyroid subtypes in order to improve patient management...
  3. The RET/PTC3 Oncogene: Antigenic and Inflammatory Properties
    LAURENCE CRANE EISENLOHR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Papillary thyroid carcinoma (PTC) is a relatively benign neoplasia, with occult lesions found in up to 10% of the general population at time of autopsy...
  4. Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention
    Mohammad Athar; Fiscal Year: 2010
    ....
  5. Hedgehog Signal Transduction Across the Cell Membrane
    Lawrence Lum; Fiscal Year: 2010
    ..Direct interaction of Hh with the twelve transmembrane protein Patched (Ptc) is required for relinquishing Ptc-mediated suppression of the seven transmembrane protein Smoothened (Smo) in ..
  6. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ..lines representing primary and metastatic tumors of different histologic types and mutational subtypes (BRAF, RET/PTC, RAS, PIK3CA, AKT1, CTNNB1)...
  7. Metastatic protein network in BRAFV600E positive human thyroid cancers
    Carmelo Nucera; Fiscal Year: 2013
    ..BRAFV600E, the most frequent genetic alteration in both papillary (PTC) and anaplastic thyroid cancers (ATC), is implicated in progression from PTC to ATC...
  8. MICHAEL MINGZHAO XING; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Thyroid cancer, particularly papillary thyroid cancer (PTC), is a common endocrine malignancy that has been rising rapidly in incidence in recent years...
  9. Yuri E Nikiforov; Fiscal Year: 2016
    ..previous cycles of this proposal, we have established the central role of chromosomal rearrangements, such as RET/PTC, in radiation-induced thyroid carcinogenesis, and created in vitro models of dose-dependent induction of RET/PTC in ..
  10. James A Fagin; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Papillary thyroid cancers (PTC) are associated with a high prevalence of non-overlapping mutations of RET, TRK, RAS, and BRAF...
  11. Cooperative of Hras or Braf wiht Pten in Thyroid Carcinogenesis
    Aime T Franco; Fiscal Year: 2010
    ..thyroid cancer (FTC), while mutations in BRAF are the most prevalent genetic defect in papillary thyroid cancer (PTC)...
  12. Lawrence S Kirschner; Fiscal Year: 2016
    ..Papillary thyroid cancer (PTC) accounts for about 80% of cases, whereas follicular thyroid cancer (FTC) accounts for the majority of the ..
  13. REBECCA ELIZABETH SCHWEPPE; Fiscal Year: 2016
    ..Oncogenic alterations in BRAF, RET/PTC, RAS, and PIK3CA are common in many thyroid cancers, and targeted therapies against these pathways are being tested...
  14. Matthew D Ringel; Fiscal Year: 2016
    ..Specifically, we will functionally characterize genes that predispose to PTC in families identified in the first cycle of the P01 and apply new technologies to a larger number of informative ..
  15. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..NMD degrades mature mRNAs with a premature termination codon (PTC)...
  16. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..However, diagnosis of AMR is one of the most challenging in renal pathology. Peritubular capillary (PTC) C4d staining is one of the markers of AMR...
  17. The molecular basis for a broad range of phenotypes related to hTAS2R38
    Sarah V Lipchock; Fiscal Year: 2012
    ..Variants of the TAS2R38 gene are best-documented example...
  18. Regulation of RNA Surveillance
    MILES FROME WILKINSON; Fiscal Year: 2012
    ..One-third of human genetic diseases are caused by PTC- containing mutant genes with nonsense or frameshift mutations...
  19. Nicholas F Larusso; Fiscal Year: 2016
    ..miR-15a, overexpressed Cdc25A (a cell cycle protein targeted by miR-15a), and increased Hedgehog (Hh) components (Ptc, Smo and Gli-2);and (iv) pharmacologic reduction of cAMP and upregulation of miR-15a with accompanying decrease of ..
  20. African Diversity and the Genetics of Human Health
    Joseph P Jarvis; Fiscal Year: 2011
    ..weight, body mass index (BMI), blood glucose level, resting blood pressure, resting heart rate, taste perception (PTC, Salicin and SOA) and lactase persistence...
  21. JOSEPH VINCENT BONVENTRE; Fiscal Year: 2016
    ..cyclin D1, ELF4/MEF, CHK1, CHK2, p53 and gH2AX) and relate these findings to the differentiation status of the PTC. We will evaluate the effects of targeted genetic deletion of ATM or ATR in the kidney tubule on cell cycle arrest ..
  22. Rongsheng Jin; Fiscal Year: 2016
    ..and function of BoNT PTCs, including the mechanism by which NAPs protect BoNTs, the regulatory mechanism underlying PTC assembly, and the structural basis by which NAPs regulate the interaction between BoNTs and host cells...
  23. Wei Liu; Fiscal Year: 2015
    ..The department's Proton Therapy Center-Houston (PTC-H) began patient treatments in May 2006...
  24. Regulation of Apoptosis in Renal Ischemia
    Babu J Padanilam; Fiscal Year: 2013
    ..Over expression of Siva led to apoptotic cell death of renal proximal tubular cells (PTC) in vitro by caspase-dependent and independent mechanisms...
  25. Denver Prevention Training Center
    Mark W Thrun; Fiscal Year: 2010
    The Denver Sexually Transmitted Disease/Human Immunodeficiency Virus (STD/HIV) Prevention Training Center (PTC) Part I will provide clinical training for STD medical and laboratory services throughout Region VIII, including the states of ..
  26. Structure determination of reaction intermediates in macromolecular complexes
    Amie K Boal; Fiscal Year: 2013
    ..Cfr-mediated methylation of the 23S ribosom is implicated in resistance to antibiotics that target the PTC. RlmN and Cfr target a specific adenine site within the 23S subunit and are most active in the context of large ..
  27. Amie K Boal; Fiscal Year: 2015
    ..Cfr-mediated methylation of the 23S ribosome is implicated in resistance to antibiotics that target the PTC. RlmN and Cfr target a specific adenine site within the 23S subunit and are most active in the context of large ..
  28. Tatyana V Pestova; Fiscal Year: 2015
    ..Recognition and targeting for degradation of PTC-containing mRNAs is mediated by conserved effectors, including UPF1 (a DEAD-box RNA helicase), UPF2, UPF3B and the ..
  29. ROBERT LOUDEN MACDONALD; Fiscal Year: 2014
    ..missense mutations, but recently nonsense mutations that introduce a premature translation-termination codon (PTC) and mutations in splice donor sites have been reported...
  30. Aberrant splicing of the E-cadherin gene.
    Sanjai Sharma; Fiscal Year: 2013
    ..These PTC mutations contribute to oncogenesis by expressing a truncated non-functional mRNA, which is degraded by the ..
  31. Discovery of antiviral agents targeting dengue viral translation
    JOSEPH MATTHEW COLACINO; Fiscal Year: 2012
    ..reporter construct has been established and employed in the performance of a high throughput screening of PTC's small molecule library...
  32. CRAIG ROBERT BROOKS; Fiscal Year: 2016
    ..Finally, we will examine if Kim-1-induced autophagy modulates the PTC immune response through MHC presentation...
  33. Hedgehog Signaling in the Adventitia
    Mark W Majesky; Fiscal Year: 2012
    ..Using patched (ptc)-lacZ reporter mice, adventitial Shh signaling was first detected at E15.5-E16...
  34. Guillaume F Chanfreau; Fiscal Year: 2016
    ..While the functions of this pathway in eliminating PTC-containing RNAs are well documented, the impact of this pathway in the regulation of expression and the quality ..
  35. THE SHH-GLI PATHWAY REGULATES PROSTATE GROWTH
    WADE A BUSHMAN; Fiscal Year: 2010
    ..Secreted Shh peptide binds to a transmembrane receptor Patched (Ptc) and activates the hedgehog (Hh) signal transduction pathway...
  36. Nonsense codon activation of endonuclease-mediated mRNA decay
    Daniel R Schoenberg; Fiscal Year: 2012
    Project summary/abstract In erythroid cells a premature termination codon (PTC) in exons 1 or 2 of the beta-globin gene activates a cytoplasmic endonuclease that degrades beta-globin mRNA...
  37. Treatment Retention Strategies in Transition Age Youth
    Maryann Davis; Fiscal Year: 2010
    ..The two TR interventions are: " Peer Therapy Coach (PTC);this web-based peer intervention that focuses on supporting participation in outpatient psychotherapy will be ..
  38. NINDS Exploratory/Developmental Projects in Translational Research
    Joseph Hacia; Fiscal Year: 2009
    ..One such nonsense suppressor drug, PTC-124 is in clinical trials for the treatment of cystic fibrosis and Duchenne's muscular dystrophy cases caused ..
  39. Jin Jiang; Fiscal Year: 2016
    ..The Hh signal reception system consists of two transmembrane proteins: a twelve-transmembrane protein Patched (Ptc) as the Hh receptor and a seven-transmembrane protein Smoothened (Smo) as the obligatory signal transducer...
  40. KRISTIAN EILEEN BAKER; Fiscal Year: 2015
    ..pathway has evolved to stimulate the degradation of aberrant mRNAs containing a premature nonsense codon (PTC), a signal that causes early termination of translation and, if left unchecked, the accumulation of truncated ..
  41. Kevin Fiscella; Fiscal Year: 2014
    ..through stakeholder collaboration, including refining, piloting, and evaluating the Patient-Teamlet Communication (PTC) model...
  42. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2012
    ..present on adult duct and endocrine cells within the pancreas, the same cell types that are marked by expression of Ptc, a transcriptional target gene of Hh signaling...
  43. PACAP Modulation of Shh Signaling in Medulloblastoma
    Linda M Liau; Fiscal Year: 2010
    ..deletion of the PACAP gene are more sensitive to the generation of medulloblastomas than patched-1 heterozygotes (Ptc+/'), as Ptd^'PACAP*''double heterozygous (DH) mice have a medulloblastoma incidence of 66% (..
  44. PROMIS Technical Center
    Richard Gershon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This proposed Technology Center (PTC) for the Patient-Reported Outcomes Measurement Information System (PROMIS) will provide and manage a secure, customizable data collection, management, and ..
  45. Philip A Beachy; Fiscal Year: 2015
    ..The central question is the mechanism by which the Hh receptor Patched (Ptc;Ptch1 in mammals), a transporter-like protein, acts to regulate Smoothened (Smo), a member of the seven ..
  46. Gene regulation using novel drugs modulating premature translational termination
    Joseph Dougherty; Fiscal Year: 2013
    ..that a cell's ability to make this distinction could be exploited to develop drugs to promote readthrough at a PTC but not at a normal codon. Such drugs could then be used to treat genetic disorders caused by PTCs...
  47. Laura D Cassidy; Fiscal Year: 2014
    ..of acute care hospitals are characterized as trauma centers (TC), and even fewer are pediatric trauma centers (PTC)...
  48. Karen L Beemon; Fiscal Year: 2014
    ..The stability element will also stabilize a PTC in gag, when inserted directly downstream of it...
  49. Scott A Strobel; Fiscal Year: 2015
    ..within the ribosome: peptide bond formation and peptide release within the 50S peptidyl transferase center (PTC) and mRNA cleavage within the 30S decoding center. Peptide Bond Formation and Peptide Release (Aims 1 and 2)...
  50. Enhancement of Hematopietic Stem Cell Engraftment with CD+ Marrow Progenitors
    Matthew J Schuchert; Fiscal Year: 2013
    ..of allogeneic hematopoietic stem cell engraftment Is enhanced by the co-adminlstratlon of discrete CD8+ pDC and pTC progenitors working in concert to augment their tolerogenic effect...
  51. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..This application will focus on the unique role of the PTC tissue RAS, hypothesizing that local angiotensins amplify the effects of Stx in PTC, resulting in further injury...
  52. STD/HIV Prevention Training Center
    Robert J Reed; Fiscal Year: 2010
    ..is submitting this proposal to serve as the Part III:STD/HIV Partner Services and Program Support Training Center (PTC) for the Eastern Quadrant...
  53. Climbing Up and Reaching Back: Ladder of Support for Research Careers in Biomedic
    STEPHANIE TIMMONS BROWN; Fiscal Year: 2013
    ..with high achieving high school students pursuing BBR, and 4) Assess whether a Patriots Technology Center (PTC) membership plus National Institute for General Medical Sciences (NIGMS) publications (PTC+NIGMS) condition is less ..
  54. Targeting RAF and VEGF Signaling in Thyroid Cancer
    Manisha Shah; Fiscal Year: 2006
    ..gene encoding BRAF, and mutations and genetic rearrangements involving upstream regulators of BRAF, including RET/PTC rearrangements and activation mutations of RAS occur in approximately 50% of all well-differentiated thyroid ..
  55. David Cella; Fiscal Year: 2014
    ..for their administration affords us valuable experience in collaborating with informatics experts, such as the PTC, to advance the use of these tools in research and practice...
  56. STD/HIV Prev Training Ctr, Part III, STD/HIV Partner Svcs & Prog Supp Train......
    RALPH WILMOTH; Fiscal Year: 2010
    The CDPHE has been associated with the CDC PTC project for nearly 30 years...
  57. Isozyme specific effects of PKCs in thyroid cells
    Judy Meinkoth; Fiscal Year: 2009
    ..Moreover, expression of the RET/PTC oncogene induced the selective translocation, followed by downregulation of PKCepsilon...
  58. Bruce A Molitoris; Fiscal Year: 2015
    ..tubule cells (PTCs) by altering the properties of identifiable molecular targets and that this in turn results in PTC dysfunction and ultimately nephrotoxicity...
  59. Development of ZnTe Powder Phosphor for Protein Crystallographic X-ray Detectors
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..Our phosphor will improve the performance of each of these substantially. PhosphorTech Corporation (PTC) is highly experienced in this area...
  60. Beta-globin mRNA decay in erythroid cells
    Daniel Schoenberg; Fiscal Year: 2005
    ..Many of these mutations introduce a premature termination codon (PTC) that results in the degradation of mRNA encoded by the affected allele...
  61. Hedgehog, Patched, and Gli in Medulloblastoma
    Howard Weiner; Fiscal Year: 2007
    ..The signaling pathway involving the secreted factor Sonic Hedgehog (Shh) and the downstream genes Patched (Ptc) and Gli play critical roles in brain development, particularly that of the cerebellum...
  62. MOLECULAR MECHANISMS OF HEDGEHOG SIGNALING
    Elizabeth Sztul; Fiscal Year: 2003
    ..The membrane protein Patched (Ptc) opposes Hh to inactivate specific gene expression...
  63. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2012
    ..proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to support the Science Moving towArds Research Translation and Therapy (SMARTT) program of the National Heart, ..
  64. Mechanisms of Positive Energy Balance in PROP Nontasters
    Kathleen Keller; Fiscal Year: 2009
    Inherited differences in human's ability to taste bitter thiourea compounds, specifically phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), have been studied since 1931. 70% of adults and children in the U.S...
  65. PHASE 2 STUDY OF PTC124 AS AN ORAL TREATMENT FOR NONSEN*
    Langdon Miller; Fiscal Year: 2007
    ..PK study that will be conducted as part of an overall development program aimed at obtaining regulatory approval of PTC 124 in DMD...
  66. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2013
    ..proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to support the Science Moving towArds Research Translation and Therapy (SMARTT) program of the National Heart, ..
  67. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2011
    ..proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to support the Science Moving towArds Research Translation and Therapy (SMARTT) program of the National Heart, ..