TAS1R3

Summary

Gene Symbol: TAS1R3
Description: taste 1 receptor member 3
Alias: T1R3, taste receptor type 1 member 3, sweet taste receptor T1R3, taste receptor, type 1, member 3
Species: human

Top Publications

  1. doi The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans
    A C Gerspach
    Phase 1 Research Unit, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Am J Physiol Endocrinol Metab 301:E317-25. 2011
  2. ncbi A candidate taste receptor gene near a sweet taste locus
    J P Montmayeur
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 4:492-8. 2001
  3. ncbi An amino-acid taste receptor
    Greg Nelson
    Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, California, 92093 0649, USA
    Nature 416:199-202. 2002
  4. ncbi The cysteine-rich region of T1R3 determines responses to intensely sweet proteins
    Peihua Jiang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:45068-75. 2004
  5. pmc Different functional roles of T1R subunits in the heteromeric taste receptors
    Hong Xu
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:14258-63. 2004
  6. ncbi Expression of the sweet receptor protein, T1R3, in the human liver and pancreas
    Kazumi Taniguchi
    Department of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato University, Japan
    J Vet Med Sci 66:1311-4. 2004
  7. ncbi A TAS1R receptor-based explanation of sweet 'water-taste'
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Nature 441:354-7. 2006
  8. ncbi Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain
    Ayako Koizumi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo, Japan
    Biochem Biophys Res Commun 358:585-9. 2007
  9. pmc The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Struct Biol 7:66. 2007
  10. ncbi Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
    M Max
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, New York, USA
    Nat Genet 28:58-63. 2001

Research Grants

  1. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
  2. Role of taste signaling elements in enteroendocrine cells
    Robert F Margolskee; Fiscal Year: 2013
  3. Functional characterization of endocrine taste cells
    Robert F Margolskee; Fiscal Year: 2013
  4. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
  5. Peihua Jiang; Fiscal Year: 2015
  6. Analysis of sweet receptor ligand binding and activation
    Marianna Max; Fiscal Year: 2010
  7. The sweet protein brazzein and its interaction with the human taste receptor
    Fariba M Assadi-Porter; Fiscal Year: 2012
  8. Melanie H Cobb; Fiscal Year: 2014
  9. Timothy F Osborne; Fiscal Year: 2016
  10. PHYSIOLOGY OF CALCIUM APPETITE
    Michael G Tordoff; Fiscal Year: 2013

Detail Information

Publications157 found, 100 shown here

  1. doi The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans
    A C Gerspach
    Phase 1 Research Unit, Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Am J Physiol Endocrinol Metab 301:E317-25. 2011
    ..Lactisole can inhibit the sweet taste receptor T1R2/T1R3. The objective was to use lactisole as a probe to investigate the physiological role of T1R2/T1R3 by assessing the ..
  2. ncbi A candidate taste receptor gene near a sweet taste locus
    J P Montmayeur
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Neurosci 4:492-8. 2001
    ..Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet ..
  3. ncbi An amino-acid taste receptor
    Greg Nelson
    Howard Hughes Medical Institute and Departments of Biology and Neurosciences, University of California at San Diego, La Jolla, California, 92093 0649, USA
    Nature 416:199-202. 2002
    ..This receptor, T1R1+3, is a heteromer of the taste-specific T1R1 and T1R3 G-protein-coupled receptors...
  4. ncbi The cysteine-rich region of T1R3 determines responses to intensely sweet proteins
    Peihua Jiang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:45068-75. 2004
    ..It has been shown that heterologous expression of T1R2 plus T1R3 together yields a receptor responsive to many of the above-mentioned sweet tasting ligands...
  5. pmc Different functional roles of T1R subunits in the heteromeric taste receptors
    Hong Xu
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:14258-63. 2004
    ..Surprisingly, the C-terminal transmembrane domain of T1R3 is required for recognizing sweetener cyclamate and sweet taste inhibitor lactisole...
  6. ncbi Expression of the sweet receptor protein, T1R3, in the human liver and pancreas
    Kazumi Taniguchi
    Department of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato University, Japan
    J Vet Med Sci 66:1311-4. 2004
    The expression of T1R3, a taste receptor essential for the perception of sweetness and umami-taste, was examined by immunohistochemistry to determine whether and where it may be localized in the liver and pancreas...
  7. ncbi A TAS1R receptor-based explanation of sweet 'water-taste'
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Nature 441:354-7. 2006
    ..the psychophysical responses-water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water...
  8. ncbi Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain
    Ayako Koizumi
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo, Japan
    Biochem Biophys Res Commun 358:585-9. 2007
    ..Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study ..
  9. pmc The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Struct Biol 7:66. 2007
    ..used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of rat and human TAS1R2+TAS1R3 suggested that the heptahelical ..
  10. ncbi Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
    M Max
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, New York, USA
    Nat Genet 28:58-63. 2001
    ..Mouse Tas1r3 (encoding T1r3) maps to within 20,000 bp of the marker closest to Sac (ref...
  11. pmc Human receptors for sweet and umami taste
    Xiaodong Li
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:4692-6. 2002
    ..Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners...
  12. ncbi Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste
    Peihua Jiang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:15238-46. 2005
    The detection of sweet-tasting compounds is mediated in large part by a heterodimeric receptor comprised of T1R2+T1R3. Lactisole, a broad-acting sweet antagonist, suppresses the sweet taste of sugars, protein sweeteners, and artificial ..
  13. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Physiol Genomics 32:82-94. 2007
    The Tas1r3 gene encodes the T1R3 receptor protein, which is involved in sweet taste transduction...
  14. pmc The sweet taste quality is linked to a cluster of taste fibers in primates: lactisole diminishes preference and responses to sweet in S fibers (sweet best) chorda tympani fibers of M. fascicularis monkey
    Yiwen Wang
    Department of Physiology and Pharmacology, Medical School, University of Minnesota Duluth, 1035 University Dr, Duluth, MN 55812, USA
    BMC Physiol 9:1. 2009
    ..In this study we apply a new sweet taste modifier, lactisole, commercially available as a suppressor of the sweetness of sugars on the human tongue, to test our hypothesis that sweet taste is conveyed in S fibers...
  15. pmc Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    Oliver J Mace
    Department of Biology Area 3, University of York, York YO10 5YW, UK
    J Physiol 582:379-92. 2007
    ..occurs within minutes by an increase in apical GLUT2, which correlates with reciprocal regulation of T1R2, T1R3 and alpha-gustducin versus T1R1, transducin and phospholipase C beta2...
  16. doi Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-alpha-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats
    B K Eschle
    Department of Biology and Vermont Chemical Senses Group, 109 Carrigan Drive, University of Vermont, Burlington, VT 05405, USA
    Neuroscience 163:1292-301. 2009
    T1R1/T1R3, taste-metabotropic glutamate receptor (mGluR) 4 and other taste receptors have been implicated in umami taste perceptionT1R1/T1R3 has also been identified as an L-amino acid receptor...
  17. pmc Stevia and saccharin preferences in rats and mice
    Anthony Sclafani
    Department of Psychology, Brooklyn College, Brooklyn, NY 11210, USA
    Chem Senses 35:433-43. 2010
    ..Similar tests of sweet receptor T1R3 knockout mice and brief-access licking tests with normal mice suggested that the preferences were based on sweet ..
  18. pmc Endocannabinoids selectively enhance sweet taste
    Ryusuke Yoshida
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 107:935-9. 2010
    ..Immunohistochemistry shows that CB(1) receptors are expressed in type II taste cells that also express the T1r3 sweet taste receptor component...
  19. doi Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds
    Ke Chen
    Department of Physiology and Pathophysiology, Xian JiaoTong University School of Medicine, Xian, Shaanxi, PR China
    Brain Res 1325:53-62. 2010
    ..Consistent with the changes in saccharin intake, the gene expression level of the sweet taste receptor T1R3 was significantly decreased in the high-fat diet-induced obese rats compared with the control rats...
  20. doi The capsaicin receptor participates in artificial sweetener aversion
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, Perception Physiology, PO Box 44, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 376:653-7. 2008
    ..of the above compounds, preference tests were performed in wild-type mice and mice lacking the TRPV1 channel or the T1R3 receptor, the latter being necessary for the perception of sweet taste...
  21. pmc Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice
    Keiko Yasumatsu
    Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    BMC Neurosci 10:152. 2009
    ..However, the formation of neural pathways from the increased taste cell population to nerve fibers has not yet been examined...
  22. ncbi Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of T1R ligands
    Cedrick D Dotson
    Department of Psychology and Center for Smell and Taste, University of Florida, Gainesville, Florida 32611 2250, USA
    J Neurosci 27:11242-53. 2007
    ..T1R heteromeric taste receptors mediate signal transduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1 + T1R3 receptor)...
  23. pmc An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine
    Oliver J Mace
    Department of Biology Area 3, The University of York, Heslington, York YO10 5YW, UK
    J Physiol 587:195-210. 2009
    ..Trafficking of apical GLUT2 is rapidly up-regulated by glucose and artificial sweeteners, which act through T1R2 + T1R3/alpha-gustducin to activate PLC beta2 and PKC betaII...
  24. pmc Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
    Yuko Nakagawa
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 4:e5106. 2009
    ..Sweet taste receptor is expressed in the taste buds and enteroendocrine cells acting as a sugar sensor. We investigated the expression and function of the sweet taste receptor in MIN6 cells and mouse islets...
  25. doi Receptors and transduction of umami taste stimuli
    Sue C Kinnamon
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Ann N Y Acad Sci 1170:55-9. 2009
    ..receptors that bind umami stimuli have been identified in taste buds, including the heterodimer T1R1/T1R3, truncated and brain forms of mGluR4 and mGluR1, brain mGluR2, and brain mGluR3...
  26. pmc Involvement of T1R3 in calcium-magnesium taste
    Michael G Tordoff
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Physiol Genomics 34:338-48. 2008
    ..The taste receptor gene, Tas1r3, was implicated by studies with 129.B6ByJ-Tas1r3 congenic and Tas1r3 knockout mice...
  27. ncbi Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Chem Senses 30:601-14. 2005
    ..First, transgenic mice lacking the gene for T1R3, Tas1r3, show dramatically reduced lick responsiveness to most sweeteners...
  28. pmc Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Neurosci 6:22. 2005
    The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart...
  29. pmc Taste receptors for umami: the case for multiple receptors
    Nirupa Chaudhari
    Department of Physiology and Biophysics, University of Miami, FL 33136, USA
    Am J Clin Nutr 90:738S-742S. 2009
    ..Loss of the Tas1r1 or Tas1R3 genes is reported to depress but not eliminate neural and behavioral responses to umami...
  30. ncbi Multiple receptor systems for glutamate detection in the taste organ
    Toshiaki Yasuo
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 31:1833-7. 2008
    ..To date, several GPCRs for umami compounds have been identified in taste cells, including the heterodimer T1R1/T1R3, and truncated type 1 and 4 metabotropic glutamate receptors missing most of the N-terminal extracellular domain (..
  31. doi Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes
    R L Young
    Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, Australia
    Gut 58:337-46. 2009
    ..In the tongue, sugars are detected via taste T1R2 and T1R3 receptors and signalled via the taste G-protein alpha-gustducin (G alpha(gust)) and the transient receptor ..
  32. pmc Variation in umami perception and in candidate genes for the umami receptor in mice and humans
    Noriatsu Shigemura
    Kyushu University, Fukuoka, Japan
    Am J Clin Nutr 90:764S-769S. 2009
    ..consists of the T1R1 (taste receptor type 1, member 1, Tas1r1) and the T1R3 (taste receptor type 1, member 3, Tas1r3) proteins, functions as an umami taste receptor for rodents and humans...
  33. ncbi Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    Carole Bezençon
    Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Chem Senses 32:41-9. 2007
    ..The PCR data showed that T1r1, T1r2, T1r3, alpha-gustducin, phospholipase Cbeta2 (PLCbeta2), and Trpm5 are expressed in the stomach, small intestine, and ..
  34. pmc Perception of sweet taste is important for voluntary alcohol consumption in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Genes Brain Behav 7:1-13. 2008
    ..mice, each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5...
  35. pmc Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice
    Sami Damak
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, New York, 10029, USA
    BMC Neurosci 9:96. 2008
    ..To determine how WGA produced in T1r3-expressing taste cells is transported into gustatory neurons, transgenic mice expressing WGA-IRES-GFP driven by the ..
  36. doi Multiple receptors underlie glutamate taste responses in mice
    Keiko Yasumatsu
    Kyushu University, Higashi ku, Fukuoka, Japan
    Am J Clin Nutr 90:747S-752S. 2009
    ..studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, ..
  37. pmc Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice
    Steven Zukerman
    Department of Psychology, Brooklyn College of CUNY, Brooklyn, NY 11210, USA
    Chem Senses 34:685-94. 2009
    Prior work has shown that sweet taste-deficient T1R3 knockout (KO) mice developed significant sucrose preferences when given long-term sugar versus water tests...
  38. ncbi Expression of metabotropic glutamate receptor group I in rat gustatory papillae
    Takashi Toyono
    Department of Oral Anatomy and Neurobiology, Kyushu Dental College, Kokurakita ku, 803 8580, Kitakyushu, Japan
    Cell Tissue Res 313:29-35. 2003
    Taste-metabotropic glutamate receptor 4 (taste-mGluR4) and the heteromers of T1R1 and T1R3 are candidate receptors involved in the sense of umami (monosodium glutamate) taste...
  39. doi Generation and characterization of T1R2-LacZ knock-in mouse
    Ken Iwatsuki
    Institute for Innovation, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    Biochem Biophys Res Commun 402:495-9. 2010
    ..has been identified as a sole sweet taste receptor in mammals that mediates sweet signals upon dimerization with T1R3. However, because of limited availability of reliable antibodies and low expression level of G protein-coupled ..
  40. doi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
    ..preference tests (two bottles, brief access) were performed in wild-type (WT) mice and in mice lacking (1) the T1R3 receptor, (2) TRPV1, the capsaicin receptor, or (3) the TRPM5 channel, the latter being necessary for the ..
  41. doi The neuropeptides CCK and NPY and the changing view of cell-to-cell communication in the taste bud
    Scott Herness
    College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 97:581-91. 2009
    ..Preliminary evidence suggests the NPY-1 receptor expressing cell co-expresses T1R3, a member of the T1R family of G-protein coupled receptors thought to be important in detection of sweet and umami ..
  42. pmc Sweet taste signaling functions as a hypothalamic glucose sensor
    Xueying Ren
    The John B Pierce Laboratory New Haven, CT, USA
    Front Integr Neurosci 3:12. 2009
    ..Here we describe for the first time the expression of the taste receptor genes Tas1r1, Tas1r2 and Tas1r3, and their associated G-protein genes, in the mammalian brain...
  43. doi Behavioral studies of umami: tales told by mice and rats
    Eugene R Delay
    Department of Biology and Vermont Chemical Senses Group, University of Vermont, Burlington, Vermont 05406, USA
    Ann N Y Acad Sci 1170:41-5. 2009
    ..When the G protein-coupled receptor T1R1+T1R3 was discovered, it was believed to be the umami receptor and a more broadly tuned L-amino acid receptor...
  44. ncbi Behavioral evidence for a role of alpha-gustducin in glutamate taste
    Collin J Ruiz
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Chem Senses 28:573-9. 2003
    ..for glutamate have been identified, a truncated form of mGluR4 (taste-mGluR4) and the presumed heterodimer T1R1 + T1R3. Both receptors respond to glutamate when expressed in heterologous cells, but the G protein involved is not known...
  45. ncbi Behavioral comparisons of the tastes of L-alanine and monosodium glutamate in rats
    Carol C Taylor-Burds
    Neuroscience Program, Department of Psychology, Regis University, 3333 Regis Blvd, Denver, CO 80221, USA
    Chem Senses 29:807-14. 2004
    Recent research has implicated T1R1/T1R3 as the primary taste receptor in mammals for detecting L-amino acids, including L-monosodium glutamate (MSG) and L-alanine...
  46. ncbi Temporal changes in NCAM immunoreactivity during taste cell differentiation and cell lineage relationships in taste buds
    Hirohito Miura
    National Food Research Institute, 2 1 12 Kannondai, Ibaraki 305 8642, Japan
    Chem Senses 30:367-75. 2005
    ..expression of NCAM was examined in Mash1-expressing taste cells of adult mice in comparison with gustducin- and T1r3-expressing cells, using a combination of NCAM immunohistochemistry and in situ hybridization...
  47. ncbi The liaison of sweet and savory
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 31:221-5. 2006
    ..individualized transduction pathways, sweet and umami tastes are believed to share a common receptor element, the T1R3 receptor subunit...
  48. ncbi Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice
    E R Delay
    Department of Psychology, Regis University, Denver, CO, USA
    Chem Senses 31:351-7. 2006
    ..studies have identified heterodimers of the T1R family as receptors for detecting the tastes of sweet (T1R2 + T1R3) and umami (T1R1 + T1R3)...
  49. pmc Is glycine "sweet" to mice? Mouse strain differences in perception of glycine taste
    Satoshi Manita
    Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    Chem Senses 31:785-93. 2006
    ..129.B6-Tas1r3 congenic mice with 2 genotypes of the Tas1r3 locus (B6/129 heterozygotes and 129/129 homozygotes) did not differ ..
  50. pmc The human sweet tooth
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia PA 19104, USA
    BMC Oral Health 6:S17. 2006
    ..Our studies demonstrate that there are two sweet receptor genes (TAS1R2 and TAS1R3), and alleles of one of the two genes predict the avidity with which some mammals drink sweet solutions...
  51. ncbi Expression of T1Rs and gustducin in palatal taste buds of mice
    Leslie M Stone
    Rocky Mountain Taste and Smell Center, Aurora, CO 80045, USA
    Chem Senses 32:255-62. 2007
    ..In contrast to lingual taste buds, however, T1R2 and T1R3-positive palatal taste cells almost always coexpress gustducin, suggesting that sweet taste transduction in the ..
  52. ncbi Comparison of L-monosodium glutamate and L-amino acid taste in rats
    E R Delay
    Department of Biology, Marsh Life Science, University of Vermont, Burlington, VT 05405, USA
    Neuroscience 148:266-78. 2007
    T1R2/T1R3 heterodimers are selectively responsive to sweet substances whereas T1R1/T1R3 receptors are selective for umami substances, represented by monosodium glutamate (MSG), and for L-amino acids...
  53. ncbi Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism
    Maude Le Gall
    INSERM, UMR S 872, Centre de Recherche des Cordeliers, Paris, France
    J Cell Physiol 213:834-43. 2007
    ..Finally, we located the sweet-taste receptors T1R3 and T1R2 in plasma membranes, and we measured their cognate G alpha Gustducin mRNA levels...
  54. pmc Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    BMC Neurosci 9:110. 2008
    ..Galphagus (gustducin) couples to the T2R (bitter) receptors, which Galpha-subunit couples to the sweet (T1R2 + T1R3) receptor is presently not known...
  55. pmc Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity
    Tadahiro Ohkuri
    Graduate School of Dental Science, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Regul Integr Comp Physiol 296:R960-71. 2009
    Sweet taste transduction involves taste receptor type 1, member 2 (T1R2), taste receptor type 1, member 3 (T1R3), gustducin, and TRPM5...
  56. pmc Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons
    Christian H Lemon
    Department of Anatomy, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Neurophysiol 101:2459-71. 2009
    b>T1r3 is a critical subunit of T1r sweet taste receptors. Here we studied how the absence of T1r3 impacts responses to sweet stimuli by taste neurons in the nucleus tractus solitarius (NTS) of the mouse...
  57. doi Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
    Petrine Wellendorph
    UNIK centre for life style diseases, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Mol Pharmacol 76:453-65. 2009
    ..receptor, the G protein-coupled receptor family C, group 6, subtype A (GPRC6A), and the taste1 receptor T1R1/T1R3, which are sensing L-alpha-amino acids, the carbohydrate-sensing T1R2/T1R3 receptor, the proteolytic degradation ..
  58. doi Genetic tracing of the gustatory neural pathway originating from T1R3-expressing sweet/umami taste receptor cells
    Ichiro Matsumoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Ann N Y Acad Sci 1170:46-50. 2009
    ..WGA), was faithfully and robustly expressed in sweet/umami taste receptor cells (TRCs) under the control of mouse T1R3 gene promoter/enhancer...
  59. pmc Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3
    Emeline L Maillet
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Med Chem 52:6931-5. 2009
    We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes ..
  60. pmc Differential effects of sucrose and fructose on dietary obesity in four mouse strains
    John I Glendinning
    Department of Biological Sciences, Barnard College, Columbia University, New York, NY 10027, United States
    Physiol Behav 101:331-43. 2010
    We examined sugar-induced obesity in mouse strains polymorphic for Tas1r3, a gene that codes for the T1R3 sugar taste receptor...
  61. doi The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)
    R E Steinert
    Clinical Research Center, Department of Biomedicine, Switzerland
    Clin Nutr 30:524-32. 2011
    ..Enteroendocrine cells are thought to directly sense nutrients via α-gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)...
  62. pmc Sweet taste receptor gene variation and aspartame taste in primates and other species
    Xia Li
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 36:453-75. 2011
    ..correlates with variations in the DNA sequence of the genes encoding sweet taste receptor proteins, T1R2 and T1R3, we sequenced these genes in 9 aspartame taster and nontaster primate species...
  63. doi Stereoselective synthesis of amides sharing the guanosine 5'-monophosphate scaffold and Umami enhancement studies using human sensory and hT1R1/rT1R3 receptor assays
    Daniel Festring
    Chair of Food Chemistry and Molecular Sensory Science, Technische Universität München, Freising Weihenstephan, Germany
    J Agric Food Chem 59:8875-85. 2011
    ..the enhancing effect of these nucleotides on the l-glutamate-induced response of the functionally expressed T1R1/T1R3 umami receptor in a cell-based assay, thus underscoring the stereospecifity of the umami taste receptor binding site...
  64. pmc Genomic and genetic evidence for the loss of umami taste in bats
    Huabin Zhao
    Department of Ecology and Evolutionary Biology, University of Michigan
    Genome Biol Evol 4:73-9. 2012
    ..bats have also lost the sweet taste receptor gene Tas1r2 and the gene required for both umami and sweet tastes (Tas1r3), being the first known mammalian group to lack two of the five tastes...
  65. pmc Identification of novel sweet protein for nutritional applications
    Mutharasu Gnanavel
    Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India 570 020
    Bioinformation 7:112-4. 2011
    ..humans, the sweet taste perception is mainly due to taste-specific G protein-coupled heterodimeric receptors T1R2-T1R3. These receptors recognize diverse natural and synthetic sweeteners such as monelin, brazzein, thaumatin, curculin, ..
  66. pmc The proof is in the pudding: children prefer lower fat but higher sugar than do mothers
    J A Mennella
    Monell Chemical Senses Center, Philadelphia, PA, USA
    Int J Obes (Lond) 36:1285-91. 2012
    ..We examined whether individual differences in sucrose and fat preferences and perception are related to age, genotype and lifestyle...
  67. doi Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport
    Kristian Daly
    Epithelial Function and Development Group, Department of Functional and Comparative Genomics, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
    Am J Physiol Regul Integr Comp Physiol 303:R199-208. 2012
    The heteromeric sweet taste receptor T1R2-T1R3 is expressed on the luminal membrane of certain populations of enteroendocrine cells...
  68. doi Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin
    Tetsuya Masuda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Biochimie 95:1502-5. 2013
    ..Although it was shown that the cysteine-rich domain (CRD) of human T1R3 (hT1R3) is important for the response to thaumatin, the amino acid residues within CRD critical for response are ..
  69. doi Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion
    Jennifer A Chalmers
    Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Endocrinol 382:262-70. 2014
    ..Taste receptor, Tas1R2 mRNA expression was reduced by glucose, whereas 2-DG reduced Tas1R3 mRNA levels...
  70. doi Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation
    Kyong Kim
    Division of Metabolism and Functionality Research, Korea Food Research Institute, 62 Road 1201, Anyang Pangyo ro, Bundang gu, Sungnam si, Kyonggi Do, 463 746, Korea
    Arch Pharm Res 37:1193-200. 2014
    ..Transfection of NCI-H716 cells with siRNA specific to α-gustducin and siRNA specific to TAS1R3 had no effect on CK-induced GLP-1 secretion and Ca²⁺ increase...
  71. doi Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells
    Itaru Kojima
    Institute for Molecular and Cellular Regulation, Gunma University
    Biol Pharm Bull 38:674-9. 2015
    Subunits of the sweet taste receptors T1R2 and T1R3 are expressed in pancreatic β-cells. Compared with T1R3, mRNA expression of T1R2 is considerably lower. At the protein level, expression of T1R2 is undetectable in β-cells...
  72. pmc Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds
    Ryusuke Yoshida
    Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan
    Diabetes 64:3751-62. 2015
    ..Ob-Rb was more often expressed in taste cells that expressed T1R3 (a sweet receptor component) than in those that expressed glutamate-aspartate transporter (a marker for Type I ..
  73. doi Co-dependence of genotype and dietary protein intake to affect expression on amino acid/peptide transporters in porcine skeletal muscle
    Y Liu
    Key Laboratory of Agro ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center of Healthy Livestock and Poultry, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China
    Amino Acids 48:75-90. 2016
    ..The low-protein diet upregulated (P < 0.05) the mRNA levels for T1R1/T1R3 involved in glutamate binding, but downregulated (P < 0...
  74. doi Rubemamine and Rubescenamine, Two Naturally Occurring N-Cinnamoyl Phenethylamines with Umami-Taste-Modulating Properties
    Michael Backes
    Symrise AG, Flavors Division, Research and Technology, P O Box 1253, 37603 Holzminden, Germany
    J Agric Food Chem 63:8694-704. 2015
    ..Among the investigated amides, only rubemamine (9) and rubescenamine (10) are able to directly activate the TAS1R1-TAS1R3 umami taste receptor...
  75. pmc Immunohistochemical Analysis of Human Vallate Taste Buds
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, 12801 E 17th Avenue, Aurora, CO 80045, USA, Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 E 17th Avenue, Aurora, CO 80045, USA and
    Chem Senses 40:655-60. 2015
    ..The typical taste cell markers PLCβ2, GNAT3 (gustducin) and the T1R3 receptor stain elongated cells in human taste buds consistent with the Type II cells in rodents...
  76. doi Muscle regulatory factors regulate T1R3 taste receptor expression
    Shoichiro Kokabu
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Moroyama machi, Iruma gun, Saitama, Japan Division of Molecular Signaling and Biochemistry, Department of Health Promotion, Kyushu Dental University, Kokurakita ku, Kitakyushu, Fukuoka, Japan Electronic address
    Biochem Biophys Res Commun 468:568-73. 2015
    b>T1R3 is a T1R class of G protein-coupled receptors, composing subunit of the umami taste receptor when complexed with T1R1...
  77. doi Expression patterns of taste receptor type 1 subunit 3 and α-gustducin in the mouse testis during development
    Ting Gong
    Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Acta Histochem 118:20-30. 2016
    Taste receptor type 1 subunit 3 (T1R3) and its associated heterotrimeric G protein α-gustducin (Gα) are involved in sweet and umami sensing in taste cells...
  78. pmc Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells
    Yuko Nakagawa
    Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 10:e0144053. 2015
    ..These signals were also blocked by an inhibitor of T1R3, a subunit of the glucose-sensing receptor, and by deletion of the T1R3 gene...
  79. doi "Tasting" the cerebrospinal fluid: Another function of the choroid plexus?
    J Tomas
    CICS UBI Health Sciences Research Centre, University of Beira Interior, Avenida Infante D Henrique, 6200 506 Covilha, Portugal
    Neuroscience 320:160-71. 2016
    ..We found transcripts for some taste receptors (Tas1r1, Tas1r2, Tas1r3, Tas2r109 and Tas2r144) and for downstream signaling molecules (α-Gustducin, Plcβ2, ItpR3 and TrpM5) that encode ..
  80. doi In vitro evidence supports the presence of glucokinase-independent glucosensing mechanisms in hypothalamus and hindbrain of rainbow trout
    Cristina Otero-Rodiño
    Laboratorio de Fisioloxia Animal, Departamento de Bioloxia Funcional e Ciencias da Saude, Facultade de Bioloxia, Universidade de Vigo, Vigo E 36310, Spain
    J Exp Biol 219:1750-9. 2016
    ..genipin (UCP2 inhibitor), 1 µmol l(-1) trolox (ROS scavenger), 100 µmol l(-1) bezafibrate (T1R3 inhibitor) and 50 µmol l(-1) geranyl-geranyl pyrophosphate (LXR inhibitor)...
  81. doi What Does Diabetes "Taste" Like?
    Fabrice Neiers
    Centre des Sciences du Gout et de l Alimentation, INRA, CNRS, université de Bourgogne Franche Comté, Dijon, 21000, France
    Curr Diab Rep 16:49. 2016
    The T1R2 (taste type 1 receptor, member 2)/T1R3 (taste type 1 receptor, member 3) sweet taste receptor is expressed in taste buds on the tongue, where it allows the detection of energy-rich carbohydrates of food...
  82. pmc Sweeter and stronger: enhancing sweetness and stability of the single chain monellin MNEI through molecular design
    Serena Leone
    Dipartimento di Scienze Chimiche, Universita di Napoli Federico II, I 80126, Napoli, Italy
    Sci Rep 6:34045. 2016
    ..or sequence homology, able to elicit a sweet sensation in humans through their interaction with the dimeric T1R2-T1R3 sweet receptor...
  83. pmc Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness
    Daisuke Kohno
    Advanced Scientific Research Leaders Development Unit, Gunma UniversityMaebashi, Japan Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma UniversityMaebashi, Japan
    Front Neurosci 10:502. 2016
    ..The sweet taste receptor is a heterodimer of taste type 1 receptor 2 (T1R2) and taste type 1 receptor 3 (T1R3) and senses sweet tastes...
  84. pmc High maltose sensitivity of sweet taste receptors in the Japanese macaque (Macaca fuscata)
    Emiko Nishi
    Molecular Biology Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, 41 2 Kanrin, Inuyama, Aichi, Japan
    Sci Rep 6:39352. 2016
    ..Because sweet tastes are recognized when compounds bind to the sweet taste receptor Tas1R2/Tas1R3, we evaluated the responses of human and Japanese macaque Tas1R2/Tas1R3 to various natural sugars using a ..
  85. pmc Umami responses in mouse taste cells indicate more than one receptor
    Yutaka Maruyama
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 26:2227-34. 2006
    ..metabotropic glutamate receptor 4, truncated metabotropic glutamate receptor 1, or taste receptor 1 (T1R1) and T1R3 dimers], taken alone, did not appear to explain the taste responses observed in mouse taste cells...
  86. ncbi The heterodimeric sweet taste receptor has multiple potential ligand binding sites
    Meng Cui
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, Box 1218, New York, NY 10029, USA
    Curr Pharm Des 12:4591-600. 2006
    The sweet taste receptor is a heterodimer of two G protein coupled receptors, T1R2 and T1R3. This discovery has increased our understanding at the molecular level of the mechanisms underlying sweet taste...
  87. doi Molecular mechanism of the allosteric enhancement of the umami taste sensation
    Ole G Mouritsen
    MEMPHYS Center for Biomembrane Physics, University of Southern Denmark, Odense, Denmark
    FEBS J 279:3112-20. 2012
    The fifth taste quality, umami, arises from binding of glutamate to the umami receptor T1R1/T1R3. The umami taste is enhanced several-fold upon addition of free nucleotides such as guanosine-5'-monophosphate (GMP) to glutamate-containing ..
  88. doi Genetics of food preferences: a first view from silk road populations
    Nicola Pirastu
    Inst for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    J Food Sci 77:S413-8. 2012
    ..b>TAS1R3 was changed to TAS1R2.] gene and liking of Vodka (P= 1.6 × 10(-3)), white wine (P= 4...
  89. pmc Expression and secretion of TNF-α in mouse taste buds: a novel function of a specific subset of type II taste cells
    Pu Feng
    Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e43140. 2012
    ..markers, the TNF-α-producing cells are predominantly type II taste cells expressing the taste receptor T1R3. These cells can rapidly increase TNF-α production and secretion upon inflammatory challenges, both in vivo and in ..
  90. pmc The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy
    Eric M Wauson
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Dallas, TX 75390 9041, USA
    Mol Cell 47:851-62. 2012
    ..We identify the G protein-coupled receptor (GPCR) T1R1/T1R3 as a direct sensor of the fed state and amino acid availability...
  91. pmc Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
    Kristian Daly
    Epithelial Function and Development Group, Department of Functional and Comparative Genomics, University of Liverpool, Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 304:G271-82. 2013
    ..of a broad spectrum of L-amino acids is accomplished by the heteromeric amino acid (umami) taste receptor (T1R1-T1R3). T1R1 and T1R3 subunits are also expressed in the intestine...
  92. doi Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion
    Shingo Sato
    Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G708-14. 2013
    ..GLP-2 secretion induced by sweetening agents was inhibited by lactisole, a sweetness-antagonizing inhibitor of T1R3. In contrast, lactisole was unable to inhibit GLP-2 secretion induced by αLA alone...
  93. doi Angiotensin II modulates salty and sweet taste sensitivities
    Noriatsu Shigemura
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 33:6267-77. 2013
    ..were coexpressed with αENaC (epithelial sodium channel α-subunit, an amiloride-sensitive salt taste receptor) or T1r3 (a sweet taste receptor component). These results suggest that the taste organ is a peripheral target of AngII...
  94. pmc Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart
    Simon R Foster
    University of Queensland, School of Biomedical Sciences, Brisbane, Australia
    PLoS ONE 8:e64579. 2013
    ..and human heart tissues that revealed discrete subsets of type 2 taste receptors (TAS2/Tas2) as well as Tas1r1 and Tas1r3 (comprising the umami receptor) are expressed...
  95. doi Flavor preferences conditioned by oral monosodium glutamate in mice
    Karen Ackroff
    Department of Psychology, Brooklyn College of CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Chem Senses 38:745-58. 2013
    ..Similar to the parent B6 strain, mice missing the T1r3 element of an umami receptor or the downstream signaling component Trpm5 learned to prefer the CS+ flavor and ..
  96. doi Umami taste receptor functions as an amino acid sensor via Gαs subunit in N1E-115 neuroblastoma cells
    Yoshikage Muroi
    Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro Hokkaido, 080 8555, Japan
    J Cell Biochem 113:1654-62. 2012
    ..we examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as amino acid sensor in the cells...
  97. doi Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptor
    Elodie Maitrepierre
    Centre des Sciences du Gout et de l Alimentation, UMR6265 CNRS, UMR1324 INRA, Universite de Bourgogne, F 21000 Dijon, France
    Protein Expr Purif 83:75-83. 2012
    The sweet taste receptor is a heterodimeric receptor composed of the T1R2 and T1R3 subunits, while T1R1 and T1R3 assemble to form the umami taste receptor. T1R receptors belong to the family of class C G-protein coupled receptors (GPCRs)...
  98. pmc Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity
    Yu Kyong Shin
    Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 67:336-44. 2012
    ..The number of taste cells expressing the sweet taste receptor subunit, T1R3, and the sweet taste modulating hormone, glucagon-like peptide-1, were reduced in the 18-month-old mice...
  99. pmc Umami taste in mice uses multiple receptors and transduction pathways
    Keiko Yasumatsu
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Physiol 590:1155-70. 2012
    ..Proposed umami receptors include heteromers of taste receptor type 1, members 1 and 3 (T1R1+T1R3), and metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4)...
  100. ncbi Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor
    Piero Andrea Temussi
    Computational Biology Unit, EMBL, Heidelberg, Germany
    FEBS Lett 526:1-4. 2002
    Sweet tasting proteins interact with the same receptor that binds small molecular weight sweeteners, the T1R2-T1R3 G-protein coupled receptor, but the key groups on the protein surface responsible for the biological activity have not yet ..
  101. ncbi Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose
    Toshio Ariyasu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vitro Cell Dev Biol Anim 39:80-8. 2003
    ..We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose...

Research Grants37

  1. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
    ..The G-protein coupled receptors, T1R2 and T1R3 which form the sweet taste receptor (STR) and gustducin, the G protein involved in taste signal transduction are ..
  2. Role of taste signaling elements in enteroendocrine cells
    Robert F Margolskee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have determined that gustducin, T1R3 and several other signaling elements that underlie taste detection/transduction also are expressed in L and K subtypes of enteroendocrine cells...
  3. Functional characterization of endocrine taste cells
    Robert F Margolskee; Fiscal Year: 2013
    ..Further, we hypothesize that taste signaling mediated by gustducin, T1R3, Trpm5 and other taste transduction elements contributes importantly to the endocrine and paracrine responses of ..
  4. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
    The human sweet receptor, composed of the monomers T1R2 + T1R3, appears to be the main (and perhaps the only) receptor underlying sweet taste in humans...
  5. Peihua Jiang; Fiscal Year: 2015
    ..In Aim 1 we will sequence the genes for all three members of the T1R taste receptor family, Tas1r1, Tas1r2, and Tas1r3, from 15 Carnivora species (meerkat, domestic cat, ferret, genet, lesser and giant panda, South American coati, ..
  6. Analysis of sweet receptor ligand binding and activation
    Marianna Max; Fiscal Year: 2010
    ..program is to understand the molecular events underlying function of the heterodimeric sweet taste receptor (T1R2+T1R3)...
  7. The sweet protein brazzein and its interaction with the human taste receptor
    Fariba M Assadi-Porter; Fiscal Year: 2012
    ..the sweet receptor indicate that brazzein interacts with specific residues in the cysteine-rich domain (CRD) of the T1R3 subunit...
  8. Melanie H Cobb; Fiscal Year: 2014
    ..In aim 1 we will determine the functions of the taste receptor complex (T1R1/T1R3) in pancreatic cells. This dimeric G protein-coupled receptor (GPR) is involved in amino acid-sensing...
  9. Timothy F Osborne; Fiscal Year: 2016
    ..involved in the majority of sweet taste sensing which is a heterodimer of Taste 1 Receptor (T1R) monomers T1R2 and T1R3. The single sweet and the entire family of bitter T2 receptors are also expressed in areas outside of the oral ..
  10. PHYSIOLOGY OF CALCIUM APPETITE
    Michael G Tordoff; Fiscal Year: 2013
    ..implicated in the control of calcium consumption;the calcium-sensing receptor, Casr, and the sweet taste receptor, Tas1r3. This will be done by comparing the receptor activity of a mouse strain that avoids calcium (the C57BL/6J or B6 ..
  11. Alan C Spector; Fiscal Year: 2016
    ..The T1R1 and T1R3 subunits combine to form a heteromer in taste receptor cells that binds with L-amino acids, and the T1R2 and T1R3 ..
  12. Taste receptor signaling in beta cells and role in postprandial insulin secretion
    George Kyriazis; Fiscal Year: 2012
    ..We will use T1R3 knock out (KO) mice to investigate the role of TRs in the regulation of insulin secretion in vitro and glucose ..
  13. Gustatory coding in brainstem nuclei using a novel c-Fos-tau-LacZ mouse model
    JENNIFER STRATFORD; Fiscal Year: 2013
    ..in this central taste representation following loss of sweet- and umami- specific sensory input via deletion of the T1R3 receptor- an obligatory subunit for the detection of these qualities...
  14. Barry G Green; Fiscal Year: 2016
    ..taste primarily by modulating the rate and degree of adaptation, possibly by changes in conformation of the T1R2- T1R3 sweet taste receptor...
  15. Orosensory Contributions to Alcohol Ingestion
    Susan M Brasser; Fiscal Year: 2010
    ..New preliminary behavioral data indicate that genetic deletion of the T1r3 sweet taste receptor in mice produces indifference to alcohol in long-term intake tests at concentrations that are ..
  16. ELECTROPHYSIOLOGY OF TASTE TRANSDUCTION
    Sue Kinnamon; Fiscal Year: 2009
    ..Several G protein-coupled taste receptors have been identified: T2Rs respond to bitter, T1R2/T1R3 to sweet, and T1R1/T1R3 and taste-mGluR4 to umami stimuli...
  17. Ormond A MacDougald; Fiscal Year: 2015
    ..Based on our preliminary data, we propose the hypotheses that activation of sweet taste receptors T1R2 and T1R3 contribute to expansion of adipose tissue by stimulating differentiation of preadipocytes, and decreasing lipolysis ..
  18. The Role of the TM of T1R2 in Sweet Receptor Activation
    Marianna Max; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The human sweet receptor composed of the monomers T1R2 + T1R3, appears to be the main (and perhaps the only) receptor required to explain sweet taste in humans...
  19. Modeling Sweet Protein-Receptor Interactions
    Meng Cui; Fiscal Year: 2010
    ..STR is a heterodimer of T1R2 and T1R3, which is a G protein-coupled receptor (GPCRs) from Family C...
  20. Experience induced changes in taste sensitivities for sweeteners and monosodium g
    LINDA KENNEDY; Fiscal Year: 2009
    ..modulation and/or cooperative binding of sweet and umami receptor molecules mediated by the receptor subunit, T1R3, may be a mechanism in the induction process. T1R3 is found in both sweet and umami receptors...
  21. Molecular Mechanisms of Sweet Receptor Function
    Marianna Max; Fiscal Year: 2009
    ..The sweet receptor is composed of two type 1 taste receptor monomers (T1R2 plus T1R3), apparently as a heterodimer...
  22. Lactisole inhibits the sweet taste receptor
    Peihua Jiang; Fiscal Year: 2004
    The sense of sweet taste is mediated by the sweet taste receptor, T1R2+T1R3, which are two closely related G protein-coupled receptors of T1Rs family. T1R2+T1R3 is a broadly tuned receptor responding to all classes of sweet compounds...
  23. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  24. EARLY HUSBANDRY INFLUENCES ON ADULT PHENOTYPE
    MICHAEL TORDOFF; Fiscal Year: 2009
    ..The results will lead to better environmental controls in future work and, asa direct consequence, easierand more rapid progress with genetic analyses. ..
  25. Marking mouse taste neural circuits by transgenic expre*
    Sami Damak; Fiscal Year: 2002
    ..a red or green fluorescent protein marker (RFP or GFP) under the control of the promoter regions of T1R1, T1R3 and mT2R5, and determine by expression studies whether these promoters are able to target expression of ..
  26. The brazzein-sweet taste receptor interaction
    Goran Hellekant; Fiscal Year: 2007
    ..a). To test brazzein mutants for direct binding and activity assay with T1R2/T1R3 sweet receptors; b)...
  27. HIGH-THROUGHPUT SCEENS FOR ASSESSING TASTE SENSITIVITY
    JOHN GLENDINNING; Fiscal Year: 2001
    ..A normative data-base for both screens will be established and made available to the scientific community. The assay procedures developed will be applicable by a single laboratory technician with limited experience. ..
  28. GENETICS OF BITTER TASTE PERCEPTION IN HUMANS
    DANIELLE REED; Fiscal Year: 2002
    ..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..
  29. Ribonucleotide monophosphates and umami taste
    Eugene Delay; Fiscal Year: 2003
    ..If IMP and GMP have identical taste qualities, and these qualities are the same as MSG and the other "umami" substance. ..
  30. L-amino and acid taste in mice.
    Eugene Delay; Fiscal Year: 2005
    ..Molecular and limited behavioral studies have identified a candidate taste receptor, T1R1/T1R3, which detects umami stimuli, including monosodium glutamate, and many more L-amino acids...
  31. ALCOHOL APPETITE--A NUTRIENT CONDITIONING ANALYSIS
    Karen Ackroff; Fiscal Year: 2001
    ..It will advance our basic knowledge of the psychobiology of alcohol appetite and may provide practical benefits for controlling alcohol consumption in humans. ..
  32. ALCOHOL EFFECT ON HUMAN LACTATION AND INFANT BEHAVIOR
    JULIE MENNELLA; Fiscal Year: 2007
    ..AIM 3: To explore the role of early experiences with ethanol in mothers' milk and the emotional context of such experiences, on the recognition of, and preference for, the sensory properties of ethanol ..
  33. CENTRAL GUSTATORY ELECTROPHYSIOLOGY IN MICE
    Stuart McCaughey; Fiscal Year: 2005
    ..abstract_text> ..
  34. Long Chain Fatty Acid (LCFA) Taste Receptor CD36 in Food Choice and Consumption
    Eric Walters; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..laboratory has recently shown that a quantitative trait locus (QTL) associated with the sweet taste receptor gene, Tas1r3, influences alcohol consumption, suggesting that the taste of alcohol may be an important factor in regulation of ..
  36. Enterogenesis with the Use of an Implanted Mechanotransduction Device
    Daniel Teitelbaum; Fiscal Year: 2008
    ..Knowledge gained from this project could greatly improve the care of patients who suffer from short bowel syndrome. [unreadable] [unreadable] [unreadable]..
  37. TRANSDUCTION MECHANISMS IN GUSTATION
    M Herness; Fiscal Year: 2009
    ..abstract_text> ..