TACR1

Summary

Gene Symbol: TACR1
Description: tachykinin receptor 1
Alias: NK1R, NKIR, SPR, TAC1R, substance-P receptor, NK-1 receptor, NK-1R, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Species: human

Top Publications

  1. ncbi Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels
    Ulises Meza
    Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
    Mol Pharmacol 71:284-93. 2007
  2. ncbi Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor
    T M Fong
    Department of Molecular Pharmacology and Biochemistry, Merck Sharp and Dohme Research Laboratories, Rayway, New Jersey 07065
    Mol Pharmacol 41:24-30. 1992
  3. ncbi Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
    C De Felipe
    Instituto de Neurociencias, Universidad Miguel Hernandez, Alicante, Spain
    Nature 392:394-7. 1998
  4. ncbi Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain
    Laura Caberlotto
    Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicine Research Centre, Verona, Italy
    Eur J Neurosci 17:1736-46. 2003
  5. doi Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon
    Gustav Andersson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Regul Pept 150:81-7. 2008
  6. pmc Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:12605-10. 2008
  7. pmc NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD
    T C Yan
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    J Psychopharmacol 24:27-38. 2010
  8. doi NK1 receptor antagonism and emotional processing in healthy volunteers
    P Chandra
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 24:481-7. 2010
  9. doi NK1 receptor antagonism and the neural processing of emotional information in healthy volunteers
    Ciara McCabe
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Int J Neuropsychopharmacol 12:1261-74. 2009
  10. pmc Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Neuropsychopharmacology 34:2442-9. 2009

Research Grants

  1. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
  2. SAMUEL SCOTT MURRAY; Fiscal Year: 2014
  3. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
  4. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  5. REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDES
    Nigel W Bunnett; Fiscal Year: 2010
  6. Fadi Xu; Fiscal Year: 2014
  7. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2013
  8. James A McRoberts; Fiscal Year: 2016
  9. Ponce School of Medicine - Moffitt Cancer Center Partnership
    WARREN JACKSON PLEDGER; Fiscal Year: 2011
  10. Jay Yang; Fiscal Year: 2016

Detail Information

Publications298 found, 100 shown here

  1. ncbi Neurokinin 1 receptors trigger overlapping stimulation and inhibition of CaV2.3 (R-type) calcium channels
    Ulises Meza
    Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322, USA
    Mol Pharmacol 71:284-93. 2007
    ..This new information concerning R-type calcium channels and NK1 receptors may help in understanding nociception, synaptic plasticity, and other physiological processes...
  2. ncbi Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor
    T M Fong
    Department of Molecular Pharmacology and Biochemistry, Merck Sharp and Dohme Research Laboratories, Rayway, New Jersey 07065
    Mol Pharmacol 41:24-30. 1992
    ..These results indicate that multiple forms of the human neurokinin-1 receptor exist and the differential activation of intracellular effector may be involved in generating the complex biological effects of substance P...
  3. ncbi Altered nociception, analgesia and aggression in mice lacking the receptor for substance P
    C De Felipe
    Instituto de Neurociencias, Universidad Miguel Hernandez, Alicante, Spain
    Nature 392:394-7. 1998
    ....
  4. ncbi Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain
    Laura Caberlotto
    Department of Biology, Psychiatry CEDD, GlaxoSmithKline Medicine Research Centre, Verona, Italy
    Eur J Neurosci 17:1736-46. 2003
    ....
  5. doi Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon
    Gustav Andersson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, SE 901 87 Umea, Sweden
    Regul Pept 150:81-7. 2008
    ..In conclusion, it appears as if SPergic autocrine/paracrine effects occur in tendon tissue during the processes of tendinosis, hitherto unknown effects for human tendons...
  6. pmc Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor
    Jian Ping Lai
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:12605-10. 2008
    The neurokinin-1 receptor (NK1R) has two naturally occurring forms that differ in the length of the carboxyl terminus: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa...
  7. pmc NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD
    T C Yan
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    J Psychopharmacol 24:27-38. 2010
    Mice with functional genetic ablation of the Tacr1 (substance P-preferring receptor) gene (NK1R-/-) are hyperactive...
  8. doi NK1 receptor antagonism and emotional processing in healthy volunteers
    P Chandra
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 24:481-7. 2010
    ..Human models of emotional processing may provide a useful means of assessing the likely therapeutic potential of new treatments for depression...
  9. doi NK1 receptor antagonism and the neural processing of emotional information in healthy volunteers
    Ciara McCabe
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Int J Neuropsychopharmacol 12:1261-74. 2009
    ..Such findings confirm animal studies which support a role for NK1 receptors in emotion. Such an approach may be useful in understanding the effects of novel drug treatments prior to full-scale clinical trials...
  10. pmc Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Neuropsychopharmacology 34:2442-9. 2009
    ..Substance P (SP), a neurotransmitter in stress pathways, exerts its effects mainly through the neurokinin-1 receptor (NK1R)...
  11. doi TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence
    Sara Blaine
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Alcohol Clin Exp Res 37:E125-30. 2013
    The tachykinin receptor 1 (TACR1) gene is a promising candidate gene in the search for the genetic basis of alcohol dependence (AD); TACR1 antagonists improve symptomology not only in preclinical models of AD but also in a clinical ..
  12. ncbi Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies
    Olivier Lequin
    Unité Mixte de Recherches 7613 CNRS, Université Paul et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France
    J Biol Chem 277:22386-94. 2002
    ....
  13. ncbi Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant
    G P Randolph
    CV CNS Biological Research and Discovery Technologies, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Pharmacogenomics J 4:394-402. 2004
    ..In all cases the Y192H variant was found to display properties similar to those of the wild-type receptor...
  14. ncbi Tachykinin receptor 1 variants associated with aggression in suicidal behavior
    Ina Giegling
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:757-61. 2007
    ..We studied gene variants of Tachykinin Receptor 1 (TACR1-rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, ..
  15. doi Family-based association study of lithium-related and other candidate genes in bipolar disorder
    Roy H Perlis
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Arch Gen Psychiatry 65:53-61. 2008
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  16. doi Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain
    Clas Linnman
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Pain 149:64-70. 2010
    ..We conclude that the central NK1 receptor system is altered in human chronic pain. The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement...
  17. doi Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder
    Laura M Hodges
    Department of Psychiatry, Institute for Human Genetics, University of California, San Francisco, 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 150:65-73. 2009
    ..The genes encoding corticotropin releasing hormone receptor 1 (CRHR1), tachykinin receptor 1 (TACR1), gastrin releasing peptide (GRP), and gastrin releasing peptide receptor (GRPR) were selected as candidates for ..
  18. ncbi Endotoxemia augments neurogenic plasma exudation in guinea pig lungs
    S M Lin
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Chang Gung Med J 23:14-21. 2000
    ..Tachykinins released from nerve endings may contribute to endotoxin-related pulmonary inflammatory responses...
  19. ncbi [Stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation]
    H L Hahn
    ,
    Pneumologie 44:526-8. 1990
    ..This is despite the fact that endogenous neurokinins have been shown to be involved in vagally induced airway smooth muscle contraction and increased capillary permeability in the same species...
  20. ncbi Central and peripheral expression of neurokinin-1 and neurokinin-3 receptor and substance P-encoding messenger RNAs: peripheral regulation during formalin-induced inflammation and lack of neurokinin receptor expression in primary afferent sensory neurons
    K E McCarson
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Neuroscience 93:361-70. 1999
    ..Importantly, inflammation does not induce a phenotypic change in afferent sensory neurons providing neurokinin receptor targets for the direct sensitization of these neurons by substance P...
  21. ncbi Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation
    Karen L Reed
    Department of Surgery, Boston University School of Medicine, Massachusetts 02118, USA
    J Surg Res 108:165-72. 2002
    ..Therefore, the aim of the present study was to determine the pattern of gene expression for substance P, the neurokinin-1 receptor, and downstream mediators of substance P action during the early stages of adhesion formation in the rat...
  22. doi Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-kappaB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells
    Yung Hua Koh
    Department of Pharmacology, National University of Singapore, Singapore
    J Pharmacol Exp Ther 332:940-8. 2010
    ..The presence of substance P and its receptor, neurokinin-1 receptor (NK1R) has been shown in the pancreas and the pancreatic acinar cells...
  23. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
    ..mouse retinas and in retinas of mice with genetic deletion of the neurokinin 1 receptor, the preferred substance P receptor. Using semi-quantitative reverse transcription-polymerase chain reaction, we measured detectable levels of ..
  24. ncbi Simultaneous activation of N-methyl-D-aspartate and neurokinin-1 receptors modulates c-Fos and Zif/268 expression in the rat trigeminal nucleus caudalis
    M Koganemaru
    Department of Anesthesiology, Miyazaki Medical College, Miyazaki, Japan
    Neuroscience 98:317-23. 2000
    ..Simultaneous activation of N-methyl-D-aspartate and neurokinin-1 receptors under some specific conditions may augment synaptic transmission, contributing to long-term neuronal change...
  25. ncbi Upregulation of neurokinin-1 receptor expression in rat spinal cord by an N-terminal metabolite of substance P
    Rubén A Velázquez
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Eur J Neurosci 16:229-41. 2002
    ..Thus, SP metabolites, at times and doses that are antinociceptive, appear to enhance SP-mediated signal transduction by upregulating NK-1 receptor expression without affecting SP synthesis...
  26. pmc Morphology and synaptic input of substance P receptor-immunoreactive interneurons in control and epileptic human hippocampus
    K Toth
    Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Szigony 43, H 1450, Budapest, Hungary
    Neuroscience 144:495-508. 2007
    ..Paradoxically, in other models, it was found to be protective against seizures by activating substance P receptor (SPR)-expressing interneurons...
  27. pmc Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers
    D Adelson
    Veterans Affairs Greater Los Angeles Healthcare System, Building 115, Room 119, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 161:538-53. 2009
    Both the firing frequency of primary afferents and neurokinin 1 receptor (NK1R) internalization in dorsal horn neurons increase with the intensity of noxious stimulus...
  28. ncbi Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies
    M Juszczak
    Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Łódź, Poland
    J Physiol Pharmacol 58:829-43. 2007
    ..They have also shown that, under present experimental conditions, the stimulatory effect of NK-1 receptor activation on AVP secretion into the blood is sensitive to inhibitory influence of melatonin...
  29. ncbi Independent endocytosis of the NK(1) and NK(3) tachykinin receptors in neurons of the rat myenteric plexus
    K M Jenkinson
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
    Neuroscience 100:191-9. 2000
    ..The results demonstrate independent, agonist-induced endocytosis of NK(1) and NK(3) receptors in neurons of the myenteric plexus of rat ileum and suggest that the mechanisms of recycling of NK(1) and NK(3) receptors differ...
  30. ncbi Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice
    N M Rupniak
    Merck Sharp and Dohme Neuroscience Research Centre, Harlow, CM20 2QR, Essex, UK
    Neuropharmacology 39:1413-21. 2000
    ..using pharmacological antagonists in guinea-pigs, a species with human-like NK(1) receptors, and transgenic NK1R-/- mice. In guinea-pigs, i.c.v. infusion of the selective substance P agonist GR73632 (0...
  31. ncbi Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL mice
    Jin Ping Zhang
    Institute of Neurosciences, The Fourth Military Medical University, Shaanxi, Xi an 710032, PR China
    Neurochem Int 49:319-26. 2006
    ..patterns of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptor subunits 1-4 (GluR1-4) in substance P receptor (SPR)-containing neurons of the basal forebrain, which may act as a morphological basis for interaction ..
  32. ncbi Lack of induction of substance P gene expression by hypoxia and absence of neurokinin 1-receptor mRNAs in the rat carotid body
    E B Gauda
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287 3200, USA
    J Auton Nerv Syst 74:100-8. 1998
    ....
  33. ncbi Hypoxia upregulates lung microvascular neurokinin-1 receptor expression
    Eric D Zee
    Department of Pediatrics, Univ of Colorado School of Medicine, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L102-10. 2006
    ..We speculate that this effect may contribute to the formation of pulmonary edema in the setting of regional or environmental hypoxia...
  34. pmc Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elements
    Ricardo Saban
    Department of Physiology, The University Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Urol 7:7. 2007
    ..First, NK1R-dependent transcripts were determined and used to query known databases for their respective transcription ..
  35. ncbi Immunohistochemical demonstration of the NK(1) tachykinin receptor on muscle and epithelia in guinea pig intestine
    B R Southwell
    Department of Gastroenterology, Murdoch Children s Research Institute, Parkville, Victoria 3052, Australia
    Gastroenterology 120:1140-51. 2001
    ..This study aimed to apply optimal immunohistochemical methods to reveal the receptors...
  36. ncbi Smooth muscle, neurons and interstitial cells of guinea pig ileum: are there tachykinin neurokinin 1 receptor subtypes?
    Maria A Matuszek
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, NSW, Australia
    Pharmacology 66:61-7. 2002
    ..Alternatively, the radioligand may not recognize the guinea pig ileum muscle NK-1 receptors due to possible minor differences in their sequence or glycosylation...
  37. pmc Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord
    Juan Carlos G Marvizon
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Br J Pharmacol 140:1389-98. 2003
    The ability of peptidases to restrict neurokinin 1 receptor (NK1R) activation by exogenously applied or endogenously released neurokinins was investigated by measuring NK1R internalization in rat spinal cord slices...
  38. ncbi Role of the tachykinin NK(1) receptor in mediating contraction to 5-hydroxytryptamine and antigen in the mouse trachea
    Katelijne O De Swert
    Department Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Pulm Pharmacol Ther 20:588-95. 2007
    ..In conclusion, the 5-hydroxytryptamine-induced tracheal contraction includes a cholinergic mechanism that requires the presence of the tachykinin NK(1) receptor...
  39. ncbi Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist
    A A H P Megens
    Department of Discovery Research, Johnson and Johnson Pharmaceutical Research and Development, B 2340 Beerse, Belgium
    J Pharmacol Exp Ther 302:696-709. 2002
    ..22-2.7) and a relatively long duration (6.5-16 h, p.o.). The data attest to the specificity and sensitivity of the animal models and support a role of NK(1) receptors in various diseases...
  40. ncbi Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse
    Amy L Allen
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Brain Res 961:147-52. 2003
    ..This supports the hypothesis that increased NK-1 receptor gene expression contributes to the development and maintenance of a hyperalgesic state...
  41. ncbi Expression of functional neurokinin-1 receptors in regenerative glands during gastric wound healing in rodents
    Adrian Schmassmann
    Gastrointestinal Unit, University Hospital, University of Berne, Switzerland
    Gastroenterology 126:784-95. 2004
    ..The aim of this study was to assess whether neurokinin-1 receptors play a role in gastric wound healing...
  42. pmc Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor
    Nancy Walters
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717 3610, USA
    Infect Immun 73:317-24. 2005
    The development of the neurokinin-1 receptor-deficient (NK1R(-/-)) mouse permitted inquiry into the regulation of secretory immunoglobulin A (S-IgA) responses by substance P (SP) after oral immunization with a Salmonella enterica serovar ..
  43. ncbi P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists
    B J Smith
    Neurosciences Discovery, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton Laboratories, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Pharmacol Exp Ther 298:1252-9. 2001
    ....
  44. pmc Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors
    Erika Polgár
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Neurosci 28:13150-60. 2008
    Although most projection neurons in lamina I express the neurokinin 1 receptor (NK1r), we have identified a population of large multipolar projection cells that lack the NK1r, are characterized by the high density of gephyrin puncta that ..
  45. pmc Neurokinin-1 receptor activation in globus pallidus
    Lei Chen
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin Hong Kong, China
    Front Neurosci 3:58. 2009
    ..Based on the direct excitatory effects of SM-SP on pallidal neurons, we hypothesize that neurokinin-1 receptor activation in globus pallidus may be involved in the beneficial effect of substance P in Parkinson's disease...
  46. ncbi Cloning of a C-terminally truncated NK-1 receptor from guinea-pig nervous system
    Sarah J Baker
    Department of Anatomy and Histology, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Brain Res Mol Brain Res 111:136-47. 2003
    ..We predict that this receptor will mediate actions of substance P on neurons where immunohistochemical evidence for a full-length NK-1 receptor is lacking...
  47. ncbi In vivo signaling through the neurokinin 1 receptor favors transgene expression by Langerhans cells and promotes the generation of Th1- and Tc1-biased immune responses
    Alicia R Mathers
    Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 178:7006-17. 2007
    ..SP exerts its proinflammatory functions by binding with high affinity to the neurokinin 1 receptor (NK1R)...
  48. ncbi NK(1) receptor and its interaction with NMDA receptor in spinal c-fos expression after lower urinary tract irritation
    Takahiko Mitsui
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, 060 8638, Japan
    Am J Physiol Regul Integr Comp Physiol 283:R576-82. 2002
    ....
  49. doi The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines
    Miguel Munoz
    Research Laboratory on Neuropeptides, Virgen del Rocio University Hospital, Sevilla, Spain
    Lab Invest 90:1259-69. 2010
    ..These findings show for the first time that the NK-1 receptor may be a promising new target and that the NK-1 receptor antagonist aprepitant could be a candidate as a new antitumor drug in the treatment of human melanoma...
  50. ncbi NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2
    Miguel Munoz
    Hospital Universitario Virgen del Rocio, Seville, Spain
    Invest New Drugs 26:111-8. 2008
    ..This new action, reported here for the first time, suggests that the NK-1 receptor is a new and promising target in the treatment of human laryngeal carcinoma...
  51. ncbi Substance P receptor expression by inhibitory interneurons of the rat hippocampus: enhanced detection using improved immunocytochemical methods for the preservation and colocalization of GABA and other neuronal markers
    R S Sloviter
    Department of Pharmacology, University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724 5050, USA
    J Comp Neurol 430:283-305. 2001
    ..The recent development of neurotoxins that specifically target SPR-expressing cells suggests that it may be possible to destroy hippocampal inhibitory interneurons selectively for ..
  52. ncbi Neurokinin-1 receptor-immunoreactive neurons of the ventral respiratory group in the rat
    H Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 434:128-46. 2001
    The rostral end of the ventral respiratory group (VRG) contains neurons that are intensely neurokinin-1 receptor (NK1R) immunoreactive (ir)...
  53. pmc Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
    K S Al Ghamdi
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 164:1794-804. 2009
    ..to various brain regions, and approximately 80% of these projection cells express the neurokinin 1 receptor (NK1r), the main receptor for substance P...
  54. doi Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat
    Dominic P Geraghty
    School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia
    Pharmacology 87:214-23. 2011
    ..We speculate that adult rats may be more resistant than neonatal rats to the neuroplastic effects of systemic capsaicin administration...
  55. ncbi Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice
    T Cao
    Centre for Cardiovascular Biology and Medicine and Messengers and Signaling Group, King s College London, London, United Kingdom
    J Immunol 164:5424-9. 2000
    ..05), but did not cause further reduction of the suppressed response of knockout mice. The results provide evidence that kinin receptors participate in NK1 receptor-dependent neutrophil accumulation in inflamed mouse skin...
  56. ncbi Localization of neurokinin 1 receptor (NK1R) immunoreactivity in rat esophagus
    Hirofumi Kuramoto
    Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606 8585, Japan
    J Comp Neurol 478:11-21. 2004
    The aim of the present immunohistochemical study was to investigate the localization of neurokinin 1 receptor (NK1R) in rat esophagus and examine the relationship between NK1Rs and intrinsic cholinergic, nitrergic, or substance P (SP) ..
  57. ncbi [Effect of tissue engineered bone implantation with vascular bundle and sensory nerve bundle on expression of neurokinin 1 receptor and vasoactive intestinal peptide type 1 receptor in vivo]
    Siyuan Chen
    Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical Univeristy, Guangzhou Guangdong, 510515, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:785-91. 2010
    ..To investigate whether vascular bundle and sensory nerve bundle implantation will affect the expressions of neurokinin 1 receptor (NK1R) and vasoactive intestinal peptide type 1 receptor (VIPR1).
  58. ncbi Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor
    K McConalogue
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Biol Chem 274:16257-68. 1999
    ..We examined substance P (SP)-induced trafficking of beta-arrestin1 and the neurokinin-1 receptor (NK1R) in KNRK cells in real time using green fluorescent protein...
  59. ncbi The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2
    M M Kwatra
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 268:9161-4. 1993
    ..as those mediating phosphoinositide (PI) hydrolysis was tested by determining the phosphorylation of the substance P receptor (SPR), which is coupled to PI hydrolysis in numerous tissues...
  60. ncbi Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons
    Hong Wang
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3755-64. 2002
    Our goal was to investigate whether the neurokinin-1 receptor (NK1R)-expressing cells of the rostral ventrolateral medulla (RVLM) regulate respiration and arterial pressure (AP)...
  61. ncbi GABAergic and glycinergic synapses onto neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies
    Ying Ying Liu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Eur J Neurosci 16:1058-66. 2002
    ..Neurons in the preBötC contain intense neurokinin-1 receptor (NK1R) immunoreactivity...
  62. ncbi Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain
    Mark J Field
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA
    J Pharmacol Exp Ther 303:730-5. 2002
    ..These data suggest a synergistic interaction between gabapentin and NK(1) receptor antagonists in animal models of neuropathic pain...
  63. ncbi Relationship between two types of vesicular glutamate transporters and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats: light and electron microscopic studies
    Ying Ying Liu
    Institute of Neurosciences, The Fourth Military Medical University, Xi an 710032, China
    Eur J Neurosci 17:41-8. 2003
    Our previous study demonstrated GABAergic and glycinergic synapses onto neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the pre-Bötzinger complex (pre-BötC), the hypothesized kernel of normal respiratory rhythmogenesis...
  64. ncbi Subtypes of substance P receptor immunoreactive interneurons in the rat basolateral amygdala
    Liat Levita
    Department of Psychiatry and Behavioral Sciences, Emory University, Woodruff Memorial Building, 1639 Pierce Drive, Rm 4000, Atlanta, GA 30322, USA
    Brain Res 981:41-51. 2003
    ..of the neurotoxin SP-saporin into the basolateral amygdala (BLA) are reported to specifically lesion substance P receptor immunoreactive (SPR-IR) interneurons, and to reduce anxiety related behavior...
  65. ncbi Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines
    Miguel Munoz
    Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Invest Ophthalmol Vis Sci 46:2567-70. 2005
    ..The ability of substance P (an neurokinin-1 stimulator) to activate the cell growth of these retinoblastoma cell lines was also determined...
  66. ncbi Neurokinin-1 receptor-expressing neurons in the ventral medulla are essential for normal central and peripheral chemoreception in the conscious rat
    Eugene Nattie
    Department of Physiology, Dartmouth Medical School, Borwell Bldg, Lebanon, NH 03756 0001, USA
    J Appl Physiol (1985) 101:1596-606. 2006
    Neurokinin-1 receptor immunoreactive (NK1R-ir) neurons and processes are widely distributed within the medulla, prominently at central chemoreceptor sites...
  67. pmc Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R)
    Irene Chernova
    Department of Pediatrics, University of Pennsylvania School of Medicine and the Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Leukoc Biol 85:154-64. 2009
    ..The SP-preferring receptor neurokinin-1 receptor (NK1R) has two forms: a full-length NK1R (NK1R-F) isoform and a truncated NK1R (NK1R-T) isoform, which lacks the terminal ..
  68. ncbi Ubiquitin-dependent down-regulation of the neurokinin-1 receptor
    Graeme S Cottrell
    Departments of Surgery and Physiology, University of California, San Francisco, 94143 0660, USA
    J Biol Chem 281:27773-83. 2006
    ..Thus, chronic stimulation with SP induces ubiquitination of the NK(1)R, which mediates its degradation and down-regulation...
  69. pmc Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways
    Louis P Vera-Portocarrero
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 129:35-45. 2007
    ..The data may provide a basis for understanding mechanisms of prolonged pain which can occur in the absence of tissue injury...
  70. ncbi Do substance P and the NK1 receptor have a role in depression and anxiety?
    S McLean
    Pfizer Global Research and Development, Eastern Point Road Ms 8220 4153, Groton, CT 06340, USA
    Curr Pharm Des 11:1529-47. 2005
    ..The clinical studies are a mixture of positive, failed and negative studies on the antidepressant activity of NK(1) receptor antagonists, not unlike the early clinical results obtained with selective serotonin reuptake inhibitors...
  71. ncbi Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
    Rudolph M Navari
    Indiana University School of Medicine, South Bend, IN, USA
    Expert Opin Investig Drugs 16:1977-85. 2007
    ..Further study is needed to clarify the use of fosaprepitant for the prevention of CINV, and to clarify optimal dosing regimens that may be appropriate substitutes for oral aprepitant...
  72. doi Fosaprepitant: a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
    Rudolph M Navari
    Walther Cancer Research Center, University of Notre Dame, South Bend, IN 46617, USA
    Expert Rev Anticancer Ther 8:1733-42. 2008
    ..Further study is needed to clarify the utility of fosaprepitant in the prevention of CINV and to clarify optimal dosing regimens that may be appropriate substitutes for oral aprepitant...
  73. pmc Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits
    Andrew J Todd
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Neurosci 29:718-26. 2009
    ..with dorsal dendrites of projection neurons in laminae III and IV that express the neurokinin 1 receptor (NK1r)...
  74. ncbi Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms?
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Curr Drug Targets CNS Neurol Disord 3:113-21. 2004
    ..Further research is needed to ascertain whether the mechanism of action of NK(1) receptor antagonists may be relevant to the antidepressant treatment...
  75. ncbi [Stiff-man syndrome. Presentation of a new case]
    A Fernandez-Barreiro
    Servicio de Neurologia, Hospital Universitario Virgen de la Arrixaca, Murcia, Espana
    Rev Neurol 25:1084-7. 1997
    The stiff-man syndrome (SPR) is a rare neurological condition characterized by the presence of marked, involuntary rigidity of the axial muscles and limbs, together with intense painful muscle spasms which characteristically occur ..
  76. ncbi Improved preventive care following an intervention during an ambulatory care rotation: carryover to a second setting
    J E Korn
    Section of General Internal Medicine, University of Minnesota, Minneapolis
    J Gen Intern Med 3:156-60. 1988
    ..involving lecture, feedback, and checklists introduced during an ambulatory care rotation at one hospital (SPR) on resident performance of six preventive care measures at a second outpatient clinic (VA)...
  77. ncbi Biosensor based on enzyme-catalysed degradation of thin polymer films
    C Sumner
    Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK
    Biosens Bioelectron 16:709-14. 2001
    ..Dissolution of the polymer films was monitored by Surface Plasmon Resonance (SPR). The rate of degradation was directly related to enzyme concentration for each polymer/enzyme couple...
  78. ncbi Detection of hormone mimics in water using a miniturised SPR sensor
    A M Sesay
    Cranfield Biotechnology Centre, Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire, UK
    Environ Monit Assess 70:83-92. 2001
    ..We have incorporated a miniature integrated surface plasmon resonance (SPR) liquid sensor from Texas Instruments into a field analyser and developed a competition/inhibition assay for a ..
  79. ncbi Bilateral electrodermal activity during sleep and waking in the cat
    H Sequeira
    , , , Maroc
    Sleep 16:695-701. 1993
    ..Bilateral differences between evoked SPR amplitudes did not show significant variations as a function of the stages of vigilance...
  80. ncbi Motif 2 in adenosine kinase homologous ginseng polypeptide showed affinity to D-ribose by capillary zone electrophoresis and surface plasmon resonance
    H Kajiwara
    National Institute of Agrobiological Resources, Ibaraki, Japan
    J Chromatogr A 817:173-9. 1998
    Affinity capillary electrophoresis (ACE) and surface plasmon resonance (SPR) were applied to the analysis of anti-lipolytic acidic tetradecapeptide from Panax ginseng roots...
  81. ncbi Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901
    M Tanaka
    Pharmaceutical Research Laboratories, Sapporo Breweries Ltd, Yaizu, Japan
    Immunopharmacol Immunotoxicol 14:403-20. 1992
    The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an alpha-1,3 branched alpha-1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied...
  82. ncbi Malaria and the Narmada-river development in India: a case study of the Bargi dam
    N Singh
    Malaria Research Centre Field Station, Jabalpur, India
    Ann Trop Med Parasitol 93:477-88. 1999
    ..collected by the National Malaria Eradication Programme (NMEP) not only indicated that the slide positivity rate (SPR) for Narayanganj increased > 7...
  83. ncbi Diagnosis of Os odontoideum using kinematic magnetic resonance imaging. A case report
    T B Hughes
    Department of Orthopaedics, Allegheny University of Health Sciences, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Spine (Phila Pa 1976) 24:715-8. 1999
    ..METHODS: A single subject with known os odontoideum was examined using a Sigma SPR Kinematic Magnetic Resonance Imager (General Electric, Florence, SC)...
  84. ncbi Genomic organization and chromosomal localization of the human sepiapterin reductase gene
    T Ohye
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Toyoake, 470 1192, Japan
    Biochem Biophys Res Commun 251:597-602. 1998
    Sepiapterin reductase (SPR) catalyzes the final step of the biosynthetic pathway of tetrahydrobiopterin, which is an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases...
  85. ncbi Scatter/primary in mammography: Monte Carlo validation
    J M Boone
    Department of Radiology, University of California, Davis, Sacramento 95817, USA
    Med Phys 27:1818-31. 2000
    ..the performance of the SIERRA Monte Carlo simulation routines for the analysis of the scatter to primary ratio (SPR) in the mammography setting...
  86. ncbi Antibodies to factor XII are distinct from antibodies to prothrombin in patients with the anti-phospholipid syndrome
    D W Jone
    Kent Haemophilia Centre, United Kingdom
    Thromb Haemost 87:426-30. 2002
    ..Eight patients were further investigated using surface plasmon resonance (SPR) for antibody binding to covalently bound FXII and to covalently bound prothrombin in both Ca++ dependent and ..
  87. ncbi Expression of the neurokinin 1 receptor in the rabbit retina
    G Casini
    Dipartimento di Scienze Ambientali, Universita della Tuscia, 01100, Viterbo, Italy
    Neuroscience 115:1309-21. 2002
    ....
  88. ncbi The conserved residue Phe273(282) of PPARalpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect
    Liduo Yue
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochimie 87:539-50. 2005
    ..on the binding affinity of PPARgamma(alpha) against a series of agonists by use of surface plasmon resonance (SPR) technique and cellular transcriptional activation analysis...
  89. pmc Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
    Robert J Fisher
    Protein Chemistry Laboratory, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    Nucleic Acids Res 34:472-84. 2006
    ..We have now analyzed the interaction between NC and d(TG)4 in considerable detail, using surface plasmon resonance (SPR), tryptophan fluorescence quenching (TFQ), fluorescence anisotropy (FA), isothermal titration calorimetry (ITC) and ..
  90. ncbi Application of two-dimensional spectral surface plasmon resonance to imaging of pressure distribution in elastohydrodynamic lubricant films
    H P Ho
    Centre for Advanced Research in Photonics, and the Department of Electronic Engineering, Chinese University of Hong Kong, China
    Appl Opt 45:5819-26. 2006
    ..This technique makes use of the spectral characteristics associated with the surface plasmon resonance (SPR) effect, and it provides more spectral information in refractive index mapping than conventional contrast SPR ..
  91. ncbi Efficiency of antiscatter grids for flat-detector CT
    Yiannis Kyriakou
    Institute of Medical Physics, University of Erlangen Nurnberg, Henkestrasse 91, 91052 Erlangen, Germany
    Phys Med Biol 52:6275-93. 2007
    ..The scatter-to-primary ratio (SPR) was measured using an adapted collimator technique in order to validate our simulations...
  92. pmc Surface plasmon resonance assay for real-time monitoring of somatic coliphages in wastewaters
    Cristina Garcia-Aljaro
    Centre Nacional de Microelectrònica de Barcelona CNM IMB, CSIC, Esfera UAB, Campus UAB, 08193 Bellaterra, Spain
    Appl Environ Microbiol 74:4054-8. 2008
    The surface plasmon resonance (SPR) technique is a well-established method for the measurement of molecules binding to surfaces and the quantification of binding constants between surface-immobilized proteins and proteins in solution...
  93. doi The fate of the large striatal interneurons expressing calretinin in Huntington's disease
    Mireille Massouh
    Centre de Recherche Université Laval Robert Giffard 2601, chemin de la Canardiere, Local F 6500 Beauport, Quebec, Canada, G1J 2G3
    Neurosci Res 62:216-24. 2008
    ..Altogether, our data suggest that neurodegenerative processes at play in HD affect the expression of Cr and ChAT in the large striatal interneurons without causing their death...
  94. doi Unilateral intra-perilymphatic infusion of substance P enhances ipsilateral vestibulo-ocular reflex gains in the sinusoidal rotation test
    Hiroshi Orita
    Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Neurosci Lett 449:207-10. 2009
    ..These results indicate the possibility that SP may act on vestibular endorgans as an excitatory factor via the NK-1 receptors...
  95. doi Development of immobilization technique for liver microsomes
    Shazia Tanvir
    Laboratoire de Genie Enzymatique et Cellulaire, UMR 6022 CNRS, Universite de Technologie de Compiegne, BP 20529 60205 Compiegne Cedex, France
    Colloids Surf B Biointerfaces 68:178-83. 2009
    ..The characterization of the films was performed by surface plasmon resonance (SPR), atomic force microscopy (AFM) and environmental scanning electron microscopy (ESEM)...
  96. doi Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ)
    Soraia K P Costa
    Department of Pharmacology, Institute of Biosciences ICB I, University of Sao Paulo USP, Sao Paulo, SP 05508 900, Brazil
    Arch Toxicol 84:109-17. 2010
    ....
  97. doi Physico-chemical and antifungal properties of protease inhibitors from Acacia plumosa
    J L S Lopes
    Instituto de Física de São Carlos IFSC, Universidade de Sao Paulo USP, SP, Brazil
    Phytochemistry 70:871-9. 2009
    ..of ApTIA, ApTIB, and ApTIC to trypsin and alpha-chymotrypsin, was investigated by surface plasmon resonance (SPR), this giving dissociation constants of 0.39, 0.56 and 0.56 nM with trypsin and 7.5, 6.9 and 3...
  98. doi Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P
    Ji Ae Ko
    Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Yamaguchi, Japan
    FEBS Lett 583:2148-53. 2009
    ..Substance P also increased the transepithelial electrical resistance of a cell monolayer in a manner sensitive to GR82334. Substance P may therefore play a role in maintenance of tight junctions in the corneal epithelium...
  99. pmc A variant of TNFR2-Fc fusion protein exhibits improved efficacy in treating experimental rheumatoid arthritis
    Tong Yang
    Department of Genetic Engineering Development, Shanghai Fudan Zhangjiang Bio pharmaceutical Co, Ltd, Shanghai, China
    PLoS Comput Biol 6:e1000669. 2010
    ..49-fold higher neutralizing activity to TNFalpha, as compared to that of Etanercept. Surface plasmon resonance (SPR) based binding assay revealed that the equilibrium dissociation constant of W89Y/E92N to TNFalpha was 3...
  100. doi Synthesis and binding studies of novel diethynyl-pyridine amides with genomic promoter DNA G-quadruplexes
    Jyotirmayee Dash
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Chemistry 17:4571-81. 2011
    ..been examined by using a Förster resonance energy transfer (FRET) melting assay and surface plasmon resonance (SPR) experiments...
  101. pmc A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase η
    Yongxing Ai
    Department of Chemistry and Biochemistry, 214A Drake Hall, University of Delaware, Newark, DE 19716, USA
    Mol Biosyst 7:1874-82. 2011
    ..cerevisiae Polη UBZ domain and probed the Polη UBZ-ubiquitin interaction using a surface plasmon resonance (SPR) technique...

Research Grants68

  1. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
  2. SAMUEL SCOTT MURRAY; Fiscal Year: 2014
    ..Aim 1, we will determine the effects of C-terminal degradation of spp24 on the kinetics of its binding to TGF-bs by SPR (surface plasmon resonance) and competitive receptor binding assay...
  3. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ....
  4. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  5. REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDES
    Nigel W Bunnett; Fiscal Year: 2010
    ..It is important to understand the mechanisms of NK1R signaling in view of the pathophysiological roles of this receptor in neurogenic inflammation, pain and intestinal ..
  6. Fadi Xu; Fiscal Year: 2014
    ..This inhibition is amplified by local substance P (SP) acting on neurokinin 1 receptor (NK1R)...
  7. Use of Substance P antagonists to regulate the skin immune function
    Adriana T Larregina; Fiscal Year: 2013
    ..SP exerts its immunostimulatory functions by binding the neurokinin 1 receptor (NK1R)...
  8. James A McRoberts; Fiscal Year: 2016
    ..Using rodent models, we will test the predictions that neuropathic and visceral pain increase NMDA-induced SP release, and decrease after selective knockdown of NMDARs in primary afferents. ..
  9. Ponce School of Medicine - Moffitt Cancer Center Partnership
    WARREN JACKSON PLEDGER; Fiscal Year: 2011
    ..Appleyard in the Minority-Serving Institute (MSI) to successfully compete for a R01 grant from the National Cancer Institute (NCI) and will increase the quality of graduate education at the MSI. ..
  10. Jay Yang; Fiscal Year: 2016
    ..data documents protein:protein interaction between S1R and several pronociceptive proteins including the substance P receptor (NK1R), muscarinic M1 receptor (M1R), and the NR1 subunit of the NMDA receptor all sharing the ability to ..
  11. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    The neurokinin receptor (NK1R), the substance P-preferring receptor, is a novel therapeutic target for neuroAIDS...
  12. Earl E Carstens; Fiscal Year: 2016
    ..These hypotheses will be addressed using two murine models of chronic itch, the NC "itchy" mouse strain, and experimental dry skin. ..
  13. Kerry J Ressler; Fiscal Year: 2014
    ..These findings will energize and support a new research program aimed at translating the modulation of the Tac2/Nk3 pathway to provide novel approaches to intervention following fear and trauma exposure for the prevention of the PTSD. ..
  14. Truncated NK1R in GBM: Pharmacology and Relationship with Patient Survival
    Madan M Kwatra; Fiscal Year: 2013
    ..One such target is the neurokinin 1 receptor (NK1R), a G protein-coupled receptor that mediates the effects of substance P...
  15. Charalabos Pothoulakis; Fiscal Year: 2014
    ..Part of this project will also examine whether SP-mediated responses in human preadipocytes influence pathways that link colitis with the metabolic syndrome and insulin resistance. ..
  16. Novel Micro-X-ray Translucent Flow Cell Technology for Proteomics, a Broadly Appl
    EVA BIRNBAUM; Fiscal Year: 2009
    ..Thus, even though tethering a protein [as with surface plasmon resonance (SPR) systems] can lead to incorrect binding constants by orders-of-magnitude, most pharmaceutical companies have ..
  17. MARIO TOMAS PHILIPP; Fiscal Year: 2016
    ....
  18. STEVEN DANIEL DOUGLAS; Fiscal Year: 2014
    ..Our previous work has demonstrated that substance P (SP), the endogenous neurokinin 1 receptor (NK1R) agonist, promotes HIV infection in macrophages, whereas treatment of macrophages with NK1R antagonists inhibits ..
  19. Nanoparticle mediated in vivo cell-type specific drug delivery for pain relief
    Zhigang David Luo; Fiscal Year: 2013
    ..Promising data derived from this project will be used for the application of a larger scale NIH R01 project related to application of siRNA/nanoparticles in targeted gene silencing and pain relief. ..
  20. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
  21. MACROPHAGE ACTIVATION & SUBSTANCE P RECEPTOR EXPRESSION
    KENNETH BOST; Fiscal Year: 2006
    ..Taken together, these studies will demonstrate that substance P is an integral part of the host immune response against pathogens. ..
  22. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..not only equilibrium data, but also kinetic parameters of the interactions using surface plasmon resonance (SPR) Biacore technology...
  23. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..levels of immunity to trimeric recombinant SIV/SHIVgp140 envelope proteins using surface plasmon resonance (SPR) technology (Biacore)...
  24. Moosa Mohammadi; Fiscal Year: 2016
    ..Recombinant protein expression and engineering, x-ray crystallography, Surface Plasmon Resonance (SPR) spectroscopy, isothermal titration calorimetry (ITC), steady-state kinetics analysis, and time-resolved mass ..
  25. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..receptor's (TCR's) with various CD1 antigen-presenting molecules by surface plasmon resonance studies (SPR)...
  26. Rapid detection of botulinum toxins using a high sensitivity SPR sensor
    PAUL MELMAN; Fiscal Year: 2010
    ..Gold nanoparticles will be attached to the peptide to increase the SPR detection sensitivity...
  27. BARRY S KREUTZ; Fiscal Year: 2014
    ..Also, we discovered a novel RhoGEF, p63RhoGEF as a direct effector for Gq. (3) Using surface plasmon resonance (SPR) we established a system to measure kinetics and thermodynamics of G13-LARG interaction...
  28. MODULAR SURFACE PLASMON RESONANCE BIOSENSOR FOR IN-VITRO DETERMINATION OF PROTEIN
    Karl S Booksh; Fiscal Year: 2010
    This project combines electrokinetic (EK) methods with surface plasmon resonance (SPR) spectroscopy to construct a flexible, modular lab-on-a-chip platform for determination of target biomarkers...
  29. Surface Plasmon Resonance (SPR) Biosensor- Biacore T200
    Yousef Al-Abed; Fiscal Year: 2012
    ..Currently, proposed surface plasmon resonance (SPR) projects include searching for lead compounds to targets in rheumatoid arthritis, systemic lupus erythematosus, ..
  30. Novel targets for discovering peptide inhibitors of HIV-1 replication
    Xinhong Dong; Fiscal Year: 2011
    ..Surface plasmon resonance (SPR) will be used to evaluate the binding kinetics of the interaction...
  31. Sriram Neelamegham; Fiscal Year: 2015
    ..Surface plasmon resonance (SPR) provides measures of molecular binding affinity/kinetics...
  32. Nguyen Ly; Fiscal Year: 2016
    ..and solid performance, 2) a proprietary high resolution distortion-free prism-based surface plasmon resonance (SPR) imaging system currently under development at BI for high-throughput interaction analysis, and 3) a highly ..
  33. UAB Shared Biacore T100 Biosensor
    Randall S Davis; Fiscal Year: 2010
    ..instrumentation grant requests funding to purchase a state-of-the-art Biacore T100 surface plasmon resonance (SPR) system to establish a shared instrumentation facility at the University of Alabama at Birmingham (UAB)...
  34. John H Griffin; Fiscal Year: 2014
    ..Based on Surface Plasmon Resonance (SPR) binding studies and on prothrombinase assays, we hypothesize that the anticoagulant soluble lipids bind and ..
  35. NSAID-Phosphatidylcholine Association: Insight in GI Ulcer Pathogenesis/Therapy
    Lenard M Lichtenberger; Fiscal Year: 2010
    ..between NSAIDs, PC and bile acids we propose to use: molecular dynamic (MD) simulation;surface plasmon resonance (SPR);and nuclear magnetic resonance (NMR) spectroscopy...
  36. KENNETH R TETER; Fiscal Year: 2014
    ..To test this model, we will use a novel toxin detection system based on surface plasmon resonance (SPR) technology to quantify holotoxin and A1 subunit distributions in the cytosol, endomembrane system, and ..
  37. Biacore T100 SPR system for studying and characterizing biomolecular interaction
    Ewa Folta Stogniew; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Surface plasmon resonance (SPR) is a universal tool for studying and characterizing macromolecular interaction in a label-free state...
  38. LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors
    James Bayrer; Fiscal Year: 2013
    ..and inhibitor binding assays utilizing Differential Scanning Fluorimetry (DSF) and surface Plasmon resonance (SPR) technology...
  39. Mechanisms of BMP Receptor Kinase Dysregulation in Skeletal Dysplasias
    JAY CLEMENS GROPPE; Fiscal Year: 2011
    ..of autoinhibition by in vitro interaction analyses with the BMP kinase and FKBP12 by Surface Plasmon Resonance (SPR, BIAcore) assays, and (2) determine the crystal structures of the wildtype and Arg206His BMP kinases at ..
  40. Structure-function studies on IL-18, IL-18 binding proteins and receptors
    Junpeng Deng; Fiscal Year: 2012
    ..a combination of biophysical and biochemical methods, including x-ray crystallography, Surface Plasmon Resonance (SPR) and IL-18 bioassay...
  41. Rapid, Label-free, Multiplex Detection of MicroRNAs
    Mary S Rosendahl; Fiscal Year: 2010
    ..SPE-CPI differs from standard Surface Plasmon Resonance (SPR) detection methods, such as Biacore, in that it combines the high sensitivity of SPR with the higher stability and ..
  42. Purchase of a Biacore T200 Surface Plasmon Resonance Label-free Detection System
    Paul M Lieberman; Fiscal Year: 2013
    ..provided by applicant): Funds are requested to purchase a Biacore T200 benchtop Surface Plasmon Resonance (SPR) label-free detection system...
  43. Development of Anti-OLAM Aptamers as Novel Analgesics
    John G Bruno; Fiscal Year: 2012
    ..better emulate amino acid side chains and will be studied by ELISA-like plate assays and surface plasmon resonance (SPR). The highest affinity and most specific unmodified or modified anti-OLAM aptamers will move into animal studies...
  44. MICHAEL CYRUS MAHER; Fiscal Year: 2014
    ..The effect of these changes on affinity for viral binding partners will be assessed by Surface Plasmon Resonance (SPR)...
  45. Molecular Means for 3'Splice Site Recognition by U2AF35
    Kholiswa M Laird; Fiscal Year: 2013
    ..Surface Plasmon resonance (SPR) and isothermal titration calorimetry (ITC) methods will be used to provide a kinetic and thermodynamic description ..
  46. Structural and Functional Properties of cyclophilin D and Abeta interaction.
    Shidu Yan; Fiscal Year: 2013
    ..of AD brain and Tg mAPP mice, and the binding of recombinant CypD protein to A? with surface plasmon resonance (SPR)...
  47. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis &Epilepsy
    Hisashi Umemori; Fiscal Year: 2013
    ..Finally, we will confirm direct bindin to FGF22 and determine the Kd using surface plasmon resonance (SPR). Data from these assays will be used to inform structure-activity relationship studies for probe optimization...
  48. Tunable affinity and heat stable antibody targeting of nanoparticles
    Todd Sulchek; Fiscal Year: 2012
    ..We will measure the binding strength the VLR antibodies to the BclA antigen with surface plasmon resonance (SPR) and single-molecule binding measurements based upon atomic force microscopy force spectroscopy...
  49. Label-free and simultaneous detection of multiple bacterial pathogens and virulen
    HAO HOWARD XU; Fiscal Year: 2010
    ..Surface plasmon resonance (SPR) is a label-free technology to study biomolecular interactions in real-time...
  50. Alan V Smrcka; Fiscal Year: 2016
    ..In the previous funding period we defined the binding modes for several compounds by surface plasmon resonance (SPR) coupled with site directed mutagenesis and solved the co-crystal structure of M201 bound to the hot spot of G[..
  51. A Biacore T200 for Molecular Interaction Studies at the University of Miami
    Ralf Landgraf; Fiscal Year: 2012
    ..structures like the Comprehensive Cancer Center (which contributes to the maintenance of the proposed SPR equipment) foster interactions between basic researchers and with clinical research groups...
  52. A Nanofluidic Nanoplasmonic Platform for Multiplexing Detection of Cancer Biomark
    Jianjun Wei; Fiscal Year: 2010
    ..In contrast to current large-sized, cumbersome surface plasmon resonance (SPR) sensing technology, the proposed device is comprised of a multilayer nanostructured array that combines the ..
  53. Structural Approaches To HIV-1 Immunogen Design For BNAb Generation
    Ellis L Reinherz; Fiscal Year: 2013
    ..of nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and surface plasmon resonance (SPR) methodologies...
  54. Tahir H Tahirov; Fiscal Year: 2016
    ..a variety of methods: X-ray crystallography, small angle X-ray scattering (SAXS), surface plasmon resonance (SPR), single molecule experiments, yeast two-hybrid and polymerase reactions assays...
  55. Rapid,high content screening of research colonies for polymicrobial infection
    Michael A Lynes; Fiscal Year: 2012
    ..We propose to develop a high content assay based on the physical phenomenon of surface plasmon resonance (SPR) done in two modalities (grating coupled surface plasmon resonance;GCSPR and grating coupled surface plasmon ..
  56. BIOMEDICAL (BASIC)
    KEMMONS TUBBS; Fiscal Year: 2009
    ..substitutions in the epitope sequence using high-throughput spotted array surface plasmon resonance imaging and SPR-Biomolecular Interaction Analysis to identify the key amino acids that are critically involved in binding the ..
  57. BIOMEDICAL (BASIC)
    KEMMONS TUBBS; Fiscal Year: 2011
    ..substitutions in the epitope sequence using high-throughput spotted array surface plasmon resonance imaging and SPR-Biomolecular Interaction Analysis to identify the key amino acids that are critically involved in binding the ..
  58. BIOMEDICAL (BASIC)
    KEMMONS TUBBS; Fiscal Year: 2010
    ..substitutions in the epitope sequence using high-throughput spotted array surface plasmon resonance imaging and SPR-Biomolecular Interaction Analysis to identify the key amino acids that are critically involved in binding the ..
  59. High-content Label-free Electro-optic Surface Plasmon Resonance Assay Platform
    ERNEST FITCH GUIGNON; Fiscal Year: 2012
    ..Phase I SBIR proposal is the development of a novel instrumentation platform based on Surface Plasmon Resonance (SPR) that if validated would greatly increase the utility of this label-free technology to researchers utilizing high-..
  60. Development of Nanoscale Plasmonic Devices for Creation of a Next Generation Surf
    David H Waldeck; Fiscal Year: 2012
    ..This technology promises to displace the conventional surface plasmon resonance (SPR) methodology for studying biological interactions, hence its creation and development will have a significant ..
  61. Electro-Optically Modulated SPR: Densely Multiplexed High-Sensitivity Biosensor
    ROBERT A LIEBERMAN; Fiscal Year: 2013
    ..based on a technique that radically alters the way a mature biosensor technology - surface plasmon resonance (SPR) - is used...
  62. Biophysical Analysis of Folic Acid-Folate Binding Protein Interaction
    Kumar Sinniah; Fiscal Year: 2009
    ..folate binding protein (FBP) will be undertaken using bulk measurement methods such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) and single molecule methods such as force pulling spectroscopy...
  63. REGULATION OF GUT SUBSTANCE P RECEPTORS
    STEVEN VIGNA; Fiscal Year: 2006
    ..These studies will lead to insight into the normal mechanisms of SP NK-1R regulation and will suggest possible mechanisms of abnormal NK-1R regulation in intestinal inflammatory diseases. ..
  64. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MC CARSON; Fiscal Year: 2004
    ..abstract_text> ..
  65. SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATION
    William Weglicki; Fiscal Year: 2007
    ..The hypotheses to be pursued in the Research Plan are outlined in Illustration 1. The potential relevance of clinical MgD to proinflammatory events in heart failure and other disease processes is addressed in the text. ..
  66. Methamphetamine and the Striatal NK-1 Receptors
    JESUS ALEXANDER ANGULO; Fiscal Year: 2010
    ..This information may prove valuable for the treatment of METH abuse and may also describe a new role for this receptor in the striatum. ..
  67. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..