T cadherin

Summary

Gene Symbol: T cadherin
Description: cadherin 13
Alias: CDHH, P105, H-cadherin (heart), T-cad, T-cadherin, cadherin 13, H-cadherin (heart), heart cadherin
Species: human

Top Publications

  1. ncbi The H-cadherin (CDH13) gene is inactivated in human lung cancer
    M Sato
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Hum Genet 103:96-101. 1998
  2. pmc T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004
  3. ncbi Recent progress in T-cadherin (CDH13, H-cadherin) research
    T Takeuchi
    Department of Pathology, Kochi Medical School, Nankoku, Japan
    Histol Histopathol 16:1287-93. 2001
  4. ncbi Clinical significance of CDH13 promoter methylation in serum samples from patients with bladder transitional cell carcinoma
    Y L Lin
    Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China
    J Int Med Res 39:179-86. 2011
  5. ncbi Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells
    T Takeuchi
    Department of Pathology, Kochi Medical School, Japan
    J Neurochem 74:1489-97. 2000
  6. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
  7. ncbi T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability
    E V Semina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    Biochemistry (Mosc) 74:362-70. 2009
  8. ncbi T-cadherin protects endothelial cells from oxidative stress-induced apoptosis
    Manjunath B Joshi
    Department of Research, Cardiovascular Laboratories, Basel University Hospital, Basel, Switzerland
    FASEB J 19:1737-9. 2005
  9. ncbi H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer
    S W Lee
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts, USA
    Nat Med 2:776-82. 1996
  10. pmc Adiponectin concentrations: a genome-wide association study
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 102 752, South Korea
    Am J Hum Genet 87:545-52. 2010

Detail Information

Publications210 found, 100 shown here

  1. ncbi The H-cadherin (CDH13) gene is inactivated in human lung cancer
    M Sato
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan
    Hum Genet 103:96-101. 1998
    ..These results suggest that a combination of deletion and hypermethylation causes inactivation of the CDH13 gene in a considerable number of human lung cancers...
  2. pmc T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    Christopher Hug
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:10308-13. 2004
    ..Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals...
  3. ncbi Recent progress in T-cadherin (CDH13, H-cadherin) research
    T Takeuchi
    Department of Pathology, Kochi Medical School, Nankoku, Japan
    Histol Histopathol 16:1287-93. 2001
    ..In this manuscript, we review current advances in T-cadherin research...
  4. ncbi Clinical significance of CDH13 promoter methylation in serum samples from patients with bladder transitional cell carcinoma
    Y L Lin
    Department of Urology, Second Hospital of Tianjin Medical University, Tianjin, China
    J Int Med Res 39:179-86. 2011
    ..Demonstration of CDH13 methylation in serum may facilitate in the prediction of which patients require more aggressive additional post-operative systemic therapy...
  5. ncbi Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells
    T Takeuchi
    Department of Pathology, Kochi Medical School, Japan
    J Neurochem 74:1489-97. 2000
    ..Epidermal growth factor is known to be required for proliferation of neural stem cells. This finding, together with those of the present study, suggests that T-cadherin functions as a negative regulator of neural cell growth...
  6. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
    ..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
  7. ncbi T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability
    E V Semina
    Institute of Experimental Cardiology, Cardiology Research Center, Moscow, 121552, Russia
    Biochemistry (Mosc) 74:362-70. 2009
    ..Moreover, suppression of the T-cadherin expression significantly decreased the endothelial monolayer permeability as compared to the control (p < 0.001)...
  8. ncbi T-cadherin protects endothelial cells from oxidative stress-induced apoptosis
    Manjunath B Joshi
    Department of Research, Cardiovascular Laboratories, Basel University Hospital, Basel, Switzerland
    FASEB J 19:1737-9. 2005
    ..ROS-induced changes in T-cad expression may play an important role in controlling tissue cellularity during vascular remodeling...
  9. ncbi H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer
    S W Lee
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts, USA
    Nat Med 2:776-82. 1996
    ..These studies indicate that downregulation of H-cadherin may be frequent in the breast malignant progression and suggest that it may have prognostic value as a marker for breast cancer development...
  10. pmc Adiponectin concentrations: a genome-wide association study
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 102 752, South Korea
    Am J Hum Genet 87:545-52. 2010
    ..2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults...
  11. pmc Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study
    Hua Ling
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland, USA
    Obesity (Silver Spring) 17:737-44. 2009
    ..We additionally identified a second gene (CDH13) possibly influencing variation in adiponectin levels. The impact of these SNPs on health and disease has yet to be determined...
  12. doi CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population
    Hiroko Morisaki
    Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Hum Mutat 33:402-10. 2012
    ....
  13. doi Effects of smoking and obesity on the association between CDH13 (rs3865188) and adiponectin among Korean men: the KARE study
    Jaeseong Jo
    Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea
    Obesity (Silver Spring) 20:1683-7. 2012
    ..9, 95% CI = 1.7-9.3, P < 0.001). This study suggested that the association between CDH13 and adiponectin can be modified by lifestyle factors, such as smoking and obesity, among Korean men...
  14. doi Clinical significance of T-cadherin tissue expression in patients with bladder transitional cell carcinoma
    Yingli Lin
    Department of Urology, Second Hospital of Tianjin Medical University, No 23 Pingjiang Road, Hexi, Tianjin, PR China
    Urol Int 86:340-5. 2011
    ..To investigate the clinical significance of T-cadherin (T-cad) tissue expression in patients with bladder transitional cell carcinoma (TCC)...
  15. doi A variant upstream of the CDH13 adiponectin receptor gene and metabolic syndrome in Swedes
    Cristiano Fava
    Department of Clinical Sciences, Lund University, University Hospital of Malmo, Malmo, Sweden
    Am J Cardiol 108:1432-7. 2011
    ..In light of the role of cadherin-13 as a vascular receptor for adiponectin, our study supports the genetic basis for the role of adiponectin in MetS pathogenesis...
  16. doi Decreased serum levels of adiponectin in adult attention deficit hyperactivity disorder
    Thegna Mavroconstanti
    K G Jebsen Centre for Research on Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, 5009 Bergen, Norway Division of Psychiatry, Haukeland University Hospital, Bergen, Norway Electronic address
    Psychiatry Res 216:123-30. 2014
    ....
  17. doi Downregulation of CDH13 expression promotes invasiveness of bladder transitional cell carcinoma
    Ying Li Lin
    Department of Urology, Xuzhou Tumor Hospital Xuzhou Third People s Hospital, Xuzhou, China
    Urol Int 90:225-32. 2013
    ..To investigate the association of downregulated CDH13 expression with invasiveness of bladder transitional cell carcinoma (TCC)...
  18. pmc Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations
    He Gao
    Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
    Diabetes 62:4277-83. 2013
    ..CDH13 variants strongly influence plasma total and HMW adiponectin levels in East Asian populations but appear to alter adiponectin sensitivity, resulting in better metabolic health than expected based on circulating adiponectin levels. ..
  19. doi CDH13 genotype-dependent association of high-molecular weight adiponectin with all-cause mortality: the J-SHIPP study
    Eri Uetani
    Corresponding author Yasuharu Tabara
    Diabetes Care 37:396-401. 2014
    ....
  20. pmc Association between CDH13 variants and cardiometabolic and vascular phenotypes in a Korean population
    Ji Hyun Lee
    Cardiology Division, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 54:1305-12. 2013
    ..The purpose of this study was to evaluate the effects of SNPs of CDH13 on metabolic and vascular phenotypes...
  21. pmc LDL induces intracellular signalling and cell migration via atypical LDL-binding protein T-cadherin
    K Rubina
    Cardiology Research Center, Moscow, Russia
    Mol Cell Biochem 273:33-41. 2005
    ..01) increased migration toward an LDL gradient (0.1% BSA + 60 microg/ml LDL) in Boyden chamber migration assay. Thus LDL-binding to T-cad is capable of activating physiologically relevant intracellular signaling and functional responses...
  22. ncbi Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin
    V A Tkachuk
    Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia
    FEBS Lett 421:208-12. 1998
    We have previously described an atypical lipoprotein-binding protein of about 105 kDa (p105) in membranes of vascular smooth muscle cells (VSMCs) that is distinct from currently known lipoprotein receptors...
  23. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  24. doi T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells
    Maria Philippova
    Laboratory for Signal Transduction, Department of Biomedicine, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Cardiovasc Res 93:498-507. 2012
    ..g. angiogenesis). We hypothesize that T-cad is a regulatory component of insulin signalling in EC and therefore a determinant of the development of endothelial InsRes...
  25. ncbi RhoA and Rac mediate endothelial cell polarization and detachment induced by T-cadherin
    Maria Philippova
    Department of Research, Cardiovascular Laboratories, Basel University Hospital, Basel, Switzerland
    FASEB J 19:588-90. 2005
    ..In conclusion, these data suggest that T-cad induces cell deadhesion and polarization via RhoA-ROCK- and Rac-dependent mechanisms...
  26. pmc Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  27. ncbi LDL binds to surface-expressed human T-cadherin in transfected HEK293 cells and influences homophilic adhesive interactions
    T J Resink
    Laboratory for Cardiovascular Research, Department of Research, Basel University Hospital, CH 4031, Basel, Switzerland
    FEBS Lett 463:29-34. 1999
    ..Ca(2+)-dependent intercellular adhesion of T-cad+ was significantly inhibited by LDL. Our results support the suggestion that LDL is a physiologically relevant ligand for T-cad...
  28. pmc Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
    Elin Org
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    Hum Mol Genet 18:2288-96. 2009
    ..Its function is compatible with the BP biology and may improve the understanding of the pathogenesis of hypertension...
  29. pmc A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes
    Chia Min Chung
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Diabetes 60:2417-23. 2011
    ..Therefore, we aimed not only to identify genetic variants modulating plasma adiponectin levels but also to investigate whether these variants are associated with adiponectin-related metabolic traits and cardiovascular diseases...
  30. ncbi Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Med Mol Morphol 40:115-20. 2007
    ..In the present review, we describe recent progress in research on adiponectin receptors, with emphasis on the unique vascular adiponectin receptor, T-cadherin, and its role in vascular disease...
  31. doi T-cadherin modulates endothelial barrier function
    Alexandra V Andreeva
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Cell Physiol 223:94-102. 2010
    ..These data implicate T-cadherin in regulation of endothelial barrier function, and suggest a complex signaling network that links T-cadherin and regulation of barrier function...
  32. pmc Case-control genome-wide association study of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:906-20. 2010
    ..Thus additional genomewide association studies (GWAS) are needed...
  33. pmc Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs
    D E Adkins
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23223, USA
    Mol Psychiatry 16:321-32. 2011
    ..Although our findings require replication and functional validation, this study shows the potential of GWAS to discover genes and pathways that potentially mediate adverse effects of antipsychotic medication...
  34. pmc Genome-wide association scan of trait depression
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Biol Psychiatry 68:811-7. 2010
    ..Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders...
  35. pmc Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival
    Maria Philippova
    Department of Research, Cardiovascular Laboratories, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Mol Cell Biol 28:4004-17. 2008
    ....
  36. ncbi Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity
    G Kremmidiotis
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Genomics 49:467-71. 1998
    ..CDH16 was localized to 8q22.1, a region exhibiting loss of heterozygosity in adult acute myeloid leukemia...
  37. ncbi Expression of cell adhesion molecule T-cadherin in the human vasculature
    D Ivanov
    Laboratory for Molecular Endocrinology, Institute of Experimental Cardiology, Cardiology Research Center, 121552 Moscow, Russia
    Histochem Cell Biol 115:231-42. 2001
    ..The findings suggest a phenotype-associated expression of T-cad which may be relevant to control of the normal vascular architecture and its remodelling during atherogenesis...
  38. doi Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...
  39. pmc Human ORFeome version 1.1: a platform for reverse proteomics
    Jean François Rual
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 14:2128-35. 2004
    ..1 represents a central resource for the cloning of large sets of human ORFs in various settings for functional proteomics of many types, and will serve as the foundation for subsequent improved versions of the human ORFeome...
  40. ncbi Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas
    Shinichi Toyooka
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cancer Res 62:3382-6. 2002
    ..Our results suggest that CDH13 expression is frequently silenced by aberrant methylation in colorectal cancers and adenomas and that methylation of CDH13 commences at an early stage of multistep colorectal tumorigenesis...
  41. ncbi Expression of T-cadherin in Basal keratinocytes of skin
    Shuxia Zhou
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Invest Dermatol 118:1080-4. 2002
    ....
  42. doi Insights into the low adhesive capacity of human T-cadherin from the NMR structure of Its N-terminal extracellular domain
    Sonja A Dames
    Department of Structural Biology, University of Basel, Klingelbergstr 70, 4056 Basel, Switzerland
    J Biol Chem 283:23485-95. 2008
    ..The apparent low adhesiveness of T-cadherin suggests that it is likely to be involved in reversible and dynamic cellular adhesion-deadhesion processes, which are consistent with its role in cell growth and migration...
  43. pmc Genome-wide association scan for five major dimensions of personality
    A Terracciano
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Mol Psychiatry 15:647-56. 2010
    ..We infer that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to confidently identify associated genetic variants...
  44. doi Extracellular cadherin repeat domains EC1 and EC5 of T-cadherin are essential for its ability to stimulate angiogenic behavior of endothelial cells
    Manjunath B Joshi
    Basel University Hospital, Department of Biomedicine, Laboratory for Signal Transduction, ZLF 316, Hebelstrasse 20, CH 4031 Basel, Switzerland
    FASEB J 23:4011-21. 2009
    ..We conclude that EC1 and EC5 domains of T-cad are essential for its proangiogenic effects. DeltaI and DeltaV constructs may serve as dominant-negative mutants and as potential tools targeting excessive angiogenesis...
  45. ncbi T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca(2+)-tyrosine kinase-Erk1/2 pathway
    Dijle Kipmen-Korgun
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Graz, Austria
    J Cardiovasc Pharmacol 45:418-30. 2005
    ..Because LDL uptake was not facilitated by T-cadherin, our data suggest that T-cadherin serves as a signaling receptor for LDL that facilitates an LDL-dependent mitogenic signal in the vasculature...
  46. doi Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders?
    Bram Sizoo
    Dimence Institute of Mental Health, Deventer, The Netherlands
    World J Biol Psychiatry 11:699-708. 2010
    ..Furthermore, it is not known whether this genetic overlap is influenced by co-morbid substance use disorders (SUD)...
  47. doi T-cadherin is located in the nucleus and centrosomes in endothelial cells
    Alexandra V Andreeva
    Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Cell Physiol 297:C1168-77. 2009
    ..These findings indicate that deregulation of T-cadherin in endothelial cells may lead to disturbances in cytokinesis or centrosomal replication...
  48. pmc Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Hum Mol Genet 19:4955-64. 2010
    ..Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1-ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos...
  49. pmc Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    Jian Yu
    Cancer Epigenetics and Gene Therapy, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 4:65. 2004
    ..Therefore, DNA methylation status as such may serve as an epigenetic biomarker for both diagnosis and prognosis of human tumors, including astrocytoma...
  50. ncbi Human skin basement membrane in health and in autoimmune diseases
    L S Chan
    Medicine Service, Section of Dermatology, Lakeside Division, VA Chicago Health Care System, and Division of Immunodermatology, Department of Dermatology, Northwestern University Medical School, 300 E Superior St, Chicago, IL 60611, USA
    Front Biosci 2:d343-52. 1997
    ..laminin-1, laminin-5 (previously named kalinin, epiligrin, nicein, BM600), laminin-6 (previously named k-laminin), p105, and entactin/nidogen; the lamina densa-located type IV collagen and perlecan; and the sub-lamina densa-located ..
  51. ncbi Crucial role of nuclear factor-kappaB in neointimal hyperplasia of the mouse carotid artery after interruption of blood flow
    Francesco Squadrito
    Dept of Clinical Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Azienda Ospedaliera Universitaria G Martino, Torre Biologica 5o Piano, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Atherosclerosis 166:233-42. 2003
    ..Wild type mice (WT mice) and mice rendered deficient in p105, the precursor of p50, one of the components of the multimeric transcription factor NF-kappaB (NF-kappaB knockout ..
  52. pmc Effect of DNA methylation on identification of aggressive prostate cancer
    Joshi J Alumkal
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon, USA
    Urology 72:1234-9. 2008
    ..DNA methylation of promoter regions leads to gene silencing in many cancers. In this study, we assessed the effect of DNA methylation on the identification of recurrent prostate cancer...
  53. doi Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels
    Mingji Jin
    Division of Translational and Clinical Oncology, Molecular and Cellular Targeting Translational Oncology Center, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 100:2325-30. 2009
    ..These findings may have clinical applications for histology-directed chemotherapy with fluoropyrimidine and anti-folates in NSCLC...
  54. pmc Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis
    Mohamed Ragaa Mohamed
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, 32610, USA
    J Virol 83:9223-36. 2009
    ..virus, encode a unique family of ankyrin (ANK) repeat-containing proteins that interact directly with NF-kappaB1/p105 and inhibit the NF-kappaB signaling pathway...
  55. ncbi The effect of portal vein branch plus heterochronous hepatic artery branch ligation on liver regeneration (experimental study)
    Mohamed Magdy Essawy
    Department of General Surgery, Theodor Bilharz Research Institute, Faculty of Medicine, Giza, Egypt
    J Egypt Soc Parasitol 37:557-70. 2007
    ..In this study, the labeling index of the nuclear factor NF Kappa B (P105), a novel monoclonal antibody specific for P105 protein, was determined immunohistochemically...
  56. pmc NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule
    R I Scheinman
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599
    Mol Cell Biol 13:6089-101. 1993
    ..subunits, p50 and p52 (also called p50B), are proteolytically processed from precursors of 105 kDa (also called p105 and NFKB1) and 100 kDa (also called p100, NFKB2, and Lyt-10), respectively...
  57. ncbi Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
    Katie J Loniewski
    Division of Pathology, Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Mol Immunol 44:3715-23. 2007
    ..and -7 is mediated via a MAP3K, called TPL2/COT, which under unstimulated conditions is associated with NF kappa B1 p105, a member of the I kappa B family of proteins...
  58. pmc Stage-specific synthesis of proteins complexed to ribonucleoprotein particles and ribosomes in zoospores of Blastocladiella emersonii
    A J Jaworski
    Botany Department, University of Georgia, Athens 30602
    Mol Cell Biol 1:310-20. 1981
    ..These proteins were designated P120, P105, P64, P56, and P42 based on their molecular weights determined by gel electrophoresis...
  59. pmc Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide
    Suraj Dhungana
    Laboratories of Respiratory Biology, NIEHS, National Institutes of Health, United States Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Proteomics 8:201-13. 2009
    ..Given previous reports of an essential role for proteasomal degradation of IkappaB kinase-phosphorylated p105 in LPS activation of ERK mitogen-activated protein kinase, we tested for a role of rafts in compartmentalization of ..
  60. pmc Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    Jian Yu
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 2:29. 2002
    ..Changes in the methylation profile of the promoters represent an alternative to genetic lesions as causative factors for the tumor-specific aberrant expression of the genes...
  61. pmc Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion
    D J Vestal
    La Jolla Cancer Research Foundation, National Cancer Institute, California 92037
    J Cell Biol 119:451-61. 1992
    ..The function of T-cadherin in homophilic cell recognition implies that the mechanism of T-cadherin-induced adhesion is distinct from that of classical cadherins...
  62. ncbi Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    Naoki Yanagawa
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Lung Cancer 58:131-8. 2007
    ..004) and pleural involvement (P=0.037). In conclusion, the hypermethylation of RASSF1A or RUNX3 gene is therefore a useful biomarker to predict the prognosis in NSCLC, particularly RASSF1A due to SCCs and RUNX3 due to ACs...
  63. pmc Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities
    R J Grumont
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 91:4367-71. 1994
    The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105...
  64. ncbi Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105
    A Ciechanover
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Biochimie 83:341-9. 2001
    ..the first step in the activation of the transcriptional regulator NF-kappaB, the substrate, the precursor protein p105, is processed in a limited manner to yield the active subunit p50...
  65. pmc Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
    B N Cronstein
    New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:6377-81. 1999
    ..in the generic murine air-pouch model by using wild-type mice and mice rendered deficient in either COX-2 or p105, the precursor of p50, one of the components of the multimeric transcription factor NFkappaB...
  66. ncbi Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility
    Cédric Carli
    Endocrinologie de la Reproduction, Centre de Recherche, Hopital Saint Francois d Assise, Centre Hospitalier Universitaire de Quebec CHUQ, Faculte de Medecine, Universite Laval, Quebec, Canada
    Fertil Steril 88:1240-7. 2007
    ..To evaluate the effect of macrophage migration inhibitory factor (MIF) on sperm capacitation, a maturational process that occurs in the female reproductive tract and enables spermatozoa to become fully competent at fertilizing the oocyte...
  67. doi Relationships among endocrine and signaling-related responses to antidepressants in human monocytic U-937 blood cells: analysis of factors and response patterns
    Stefan Gebhardt
    Department of Psychiatry and Psychotherapy, Philipps University of Marburg, Rudolf Bultmann Strasse 8, D 35033 Marburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 32:1682-7. 2008
    ..by expression analysis of different factors, comprising endocrine (glucocorticoid receptor [GR], GR-alpha/beta/gamma; mineralocorticoid receptor [MR]) and signaling-related pathways (p105, STAT3, c-jun, c-fos, JNK1, GAPDH, TNF-alpha).
  68. doi Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 298:F196-204. 2010
    ..the effect of pyrrolidine dithiocarbamate (PDTC) and of small interfering RNA (siRNA) silencing NF-kappaB p50/p105 on sepsis-induced downregulation of vasopressin V(2) receptors and aquaporin (AQP)-2 channels using a cecal ..
  69. ncbi Species-specific binding of sperm proteins to the extracellular matrix (zona pellucida) of the egg
    D M Hardy
    Howard Hughes Medical Institute, University of Texas, Dallas 75235 9050
    J Biol Chem 269:19000-4. 1994
    ..Disulfide bond reduction separated each of the M(r) 130,000-170,000 proteins into M(r) 105,000 (p105) and M(r) 45,000 (p45) subunits, indicating that these high M(r) proteins are related...
  70. pmc Correlation between CpG methylation profiles and hormone receptor status in breast cancers
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 9:R57. 2007
    ..The present study was undertaken to determine whether methylation of a set of growth-suppressor genes would correlate to the expression of estrogen receptors (ERs) and progesterone receptors (PRs)...
  71. ncbi Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    Michal F Tomczak
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:7332-9. 2006
    ..The defect in response to IL-10-Ig appeared to be primarily the result of the absence of the p50/p105 subunit, because the ability of IL-10-Ig to inhibit colitis was also compromised in p50(-/-); RAG-2(-/-) (p50/RAG) ..
  72. pmc Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain
    Shoumei Bai
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 282:27171-80. 2007
    ..These data, together with the inhibitory role of T-Cad in neurite outgrowth of PC12 cells upon NGF treatment, underscore the significance of its stringent regulation during this differentiation process...
  73. ncbi P105 as a prognostic indicator in patients irradiated for locally advanced head-and-neck cancer: a clinical/laboratory correlative analysis of RTOG-9003
    E Hammond
    LDS Hospital, Salt Lake City, UT 84143, USA
    Int J Radiat Oncol Biol Phys 57:683-92. 2003
    In a previous retrospective study, p105 AD, a proliferation-associated nuclear antigen density (AD), was found to be an independent prognostic factor for patients irradiated for locally advanced head-and-neck cancer...
  74. pmc High incidence of MGMT and RARbeta promoter methylation in primary glioblastomas: association with histopathological characteristics, inflammatory mediators and clinical outcome
    Christina Piperi
    Department of Biological Chemistry, Medical School, University of Athens, 11527 Athens, Greece
    Mol Med 16:1-9. 2010
    ..0474). Our study highlights the implication of MGMT and RARbeta methylation in the aggressive phenotype of primary glioblastomas. The association of MGMT methylation with clinical outcome indicates its potential prognostic value...
  75. pmc Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues
    James C Lo
    Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Blood 107:1048-55. 2006
    ..We now demonstrate that p105/p50 also constitutes an important pathway for LTbetaR signaling...
  76. ncbi Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ
    Lionel Simonneau
    Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Institut National de la Santé et de la Recherche Médicale U254, Universite Montpellier I, 34090 Montpellier, France
    J Comp Neurol 459:113-26. 2003
    ..Synaptic plasticity in rat cochlea and hypotheses about T-cad functions and neosensory features of the Kölliker's organ are discussed...
  77. pmc Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data
    Hui Juan Yang
    Department of Gynecologic Oncology, Fudan University Cancer Hospital, Shanghai, China
    BMC Cancer 6:212. 2006
    ..The abnormal promoter methylation might be a potential molecular marker for cancer management...
  78. ncbi Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma
    Shigeru Tsunoda
    Discipline of Surgery, The University of Adelaide, South Australia 5005, Australia
    Oncol Rep 21:1067-73. 2009
    ..0007, P=0.0048 P=0.0002 and P<0.0001, respectively). This is the first report of gene silencing by methylation of CLDN6, FBN2, RBP4, TFPI2 and TMEFF2 in esophageal squamous cell carcinoma...
  79. ncbi Estimation of kinetic cell-cycle-related gene expression in G1 and G2 phases from immunofluorescence flow cytometry data
    J W Jacobberger
    Cancer Research Center, Case Western Reserve University, Cleveland, Ohio 44106 4944, USA
    Cytometry 35:284-9. 1999
    ..We present an objective method to model G1 and G2 kinetic expression from an estimate of a minimum biological unit of positive immunofluorescence derived from the distribution of specific immunofluorescence of mitotic cells...
  80. doi Differential expression of phosphorylated extracellular signal-regulated kinase 1/2, phosphorylated p38 mitogen-activated protein kinase and nuclear factor-kappaB p105/p50 in chronic inflammatory skin diseases
    Shuang Wang
    Department of Dermatology, Kyushu University, Higashiku, Fukuoka, Japan
    J Dermatol 36:534-40. 2009
    ..of phosphorylated extracellular signal-regulated kinase (ERK)1/2, phosphorylated p38 MAPK and NF-kappaB p105/p50 in chronic inflammatory skin diseases...
  81. pmc The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B
    M Naumann
    Max Planck Institut fur Molekulare Genetik, Otto Warburg Laboratorium, Berlin Dahlem, Germany
    EMBO J 12:213-22. 1993
    We have examined the interaction of the NF-kappa B precursor p105 with NF-kappa B subunits. Similar to an I kappa B molecule, p105 associates in the cytoplasm with p50 or p65...
  82. ncbi Aqueous two-phase systems containing self-associating block copolymers. Partitioning of hydrophilic and hydrophobic biomolecules
    M Svensson
    Department of Physical Chemistry 1, Lund University, Sweden
    J Chromatogr A 839:71-83. 1999
    ..Two different Pluronic copolymers were used, P105 and F68, and the phase diagrams were determined at 30 degrees C for these polymer systems...
  83. ncbi TRAF6 and Src kinase activity regulates Cot activation by IL-1
    Cristina Rodriguez
    Instituto de Investigaciones Biomedicas, CSIC, Facultad de Medicina, UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Cell Signal 18:1376-85. 2006
    ..Cot is activated by LPS, by inducing its dissociation from the inactive p105 NFkappaB-Cot complex in macrophages...
  84. ncbi Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase
    H Obaishi
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 273:18697-700. 1998
    We purified from rat brain a novel F-actin-binding protein with a Mr of about 105,000 (p105), which was estimated by SDS-polyacrylamide gel electrophoresis. We cloned its cDNA from a rat brain cDNA library and characterized it...
  85. ncbi Biogenesis of MHC class I antigens: involvement of multiple chaperone molecules
    B Kahn-Perles
    Centre d immunologie de Marseille Luminy, France
    Eur J Cell Biol 64:176-85. 1994
    ..unassembled HLA-Cw3 heavy chains (Cw3 alpha) specifically associate with three major long-lived proteins denoted p105, p88 and p78, according to their size. These proteins display different kinetics of interaction...
  86. ncbi Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice
    Gerald Weissmann
    Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Adv Exp Med Biol 507:571-7. 2002
    ..inflammation was induced in murine air-pouches of wild-type mice and mice rendered deficient in either COX-2 or p105, the precursor of p50 of NF kappa B...
  87. ncbi Elevated serum levels of the c-erbB-2 encoded oncoprotein fragment in cases of pure preeclampsia and HELLP syndrome
    H Meden
    Department of Obstetrics and Gynecology, University of Gottingen, Germany
    J Obstet Gynaecol Res 23:213-7. 1997
    ..It is accompanied by the increase of a 105 kD fragment (p105) in both maternal serum and cord blood...
  88. ncbi The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    N Dyson
    Cold Spring Harbor Laboratory, NY 11724
    Science 243:934-7. 1989
    ..Recently, the RB1 gene product, p105-RB, has been shown to form stable protein/protein complexes with the oncoproteins of two DNA tumor viruses, the ..
  89. doi Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells
    Riikka Juntunen
    Department of Clinical Microbiology, Institute of Clinical Medicine and Biocenter Kuopio, University of Kuopio, Kuopio, Finland
    Mol Immunol 46:3320-7. 2009
    ..of one of the previously identified T cell epitopes of the major dog allergen Can f 1, contained in peptide p105-120...
  90. ncbi Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability
    Francesca Demarchi
    L N C I B Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie AREA Science Park, Padriciano 99 34012 Trieste, Italy
    J Biol Chem 278:39583-90. 2003
    ..Here we investigated the molecular cross-talk between glycogen synthase kinase-3 beta (GSK-3 beta) and the p105 precursor of the NF-kappa B p50 subunit...
  91. doi Promoter hypermethylation of CDH13, DAPK1 and TWIST1 genes in precancerous and cancerous lesions of the uterine cervix
    Nabiha Missaoui
    Research Unit 03 UR 08 13, Cancer Epidemiology and Cytopathology in Tunisian Center, Medicine Faculty, Sousse, Tunisia
    Pathol Res Pract 207:37-42. 2011
    ..0001). Hypermethylation of CDH13, DAPK1, and TWIST1 promoters is an early event in the initiation and progression of cervix neoplasia. CDH13, DAPK1, and TWIST1 genes are potential biomarkers of cervical cancer risk...
  92. pmc betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932
    Valerie Lang
    Division of Immune Cell Biology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    Mol Cell Biol 23:402-13. 2003
    NF-kappaB1 p105 functions both as a precursor of NF-kappaB1 p50 and as a cytoplasmic inhibitor of NF-kappaB...
  93. ncbi T-cadherin is a major glycophosphoinositol-anchored protein associated with noncaveolar detergent-insoluble domains of the cardiac sarcolemma
    D D Doyle
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 273:6937-43. 1998
    ..These results suggest that T-cadherin is a major glycophosphoinositol-linked protein in cardiac myocytes and that it may be located in plasma membrane "rafts" distinct from but possibly adjacent to caveolae...
  94. pmc Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
    V Heissmeyer
    Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Mol Cell Biol 21:1024-35. 2001
    b>p105 (NFKB1) acts in a dual way as a cytoplasmic IkappaB molecule and as the source of the NF-kappaB p50 subunit upon processing...
  95. ncbi Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis
    Xi De Wang
    Department of Molecular Biology, MS 72, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Differentiation 75:219-34. 2007
    ....
  96. pmc Genome-wide association studies in ADHD
    Barbara Franke
    Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Genet 126:13-50. 2009
    ..Many more (much larger studies) will be needed. For this, collaboration between researchers as well as standardized protocols for phenotyping and DNA-collection will become increasingly important...
  97. ncbi Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages
    Narayanan Parameswaran
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:34159-70. 2006
    ..Upon LPS stimulation, IkappaB kinase promotes phosphorylation and degradation of NFkappaB1 p105 (p105), which releases TPL2 (a MAP3K), which phosphorylates MEK1/2, which in turn phosphorylates ERK1/2...
  98. ncbi Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines
    Yongzhong Wang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 337:63-73. 2007
    ..Micelles and mixed micelles were prepared from Pluronic block copolymer P105 or L101 as PTX delivery systems for overcoming MDR...
  99. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
    ..Our results indicate that T-cadherin is required for the ability of adiponectin to suppress some but not all aspects of ozone-induced pulmonary inflammation...
  100. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
    ..that PGE(2) pretreatment selectively inhibits lipopolysaccharide (LPS)-induced nuclear factor kappaB1 (NF-kappaB1) p105 phosphorylation and degradation in mouse bone marrow-derived macrophages through EP4-dependent mechanisms...
  101. ncbi Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dis Colon Rectum 48:1282-6. 2005
    ....

Research Grants43

  1. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
    ..abstract_text> ..
  2. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..pylori activated Macs to a tolerant regulatory phenotype in a NF-kB1 (p105/p50)-dependent manner. Tolerance may lead to persistence of H...
  3. NF-kB regulation by p105 and p100
    Gourisankar Ghosh; Fiscal Year: 2013
    ..NF-?B1 (also called p105/p50) and NF-?B2 (also called p100/p52) belong to both the NF-?B and I?B families...
  4. Inflammatory regulation of lipid accumulation in skeletal muscle with obesity
    Matthew W Hulver; Fiscal Year: 2012
    ..Specific Aim 2 proposes the use of TLR4 mutant (C3H/HeJ) and NF-kB knockout (nfkb1- p105) animals to demonstrate that both TLR4 and NF-kB are critically important for SCD1 regulation...
  5. Manipulation of inflammasomes and NF-kB signaling in human myeloid cells by Myxom
    Grant McFadden; Fiscal Year: 2013
    ..ASC-1 (apoptosis-associated speck-like protein containing a CARD) of various inflammasome complexes and NF-?B1/p105 of NF-?B signaling pathway...
  6. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2009
    ..We have developed an NF-kappaB super represser based on NF-kappaB inhibitor p105, and demonstrated that p105(sr) broadly and effectively inhibits all NF-kappaB species...
  7. Inhibition of Microflora-Induced Colitis by NF-kB
    Bruce H Horwitz; Fiscal Year: 2010
    ..Mice lacking the p50/p105 subunit of NF-(B are sensitized to the development of colitis, due at least in part to a defect within ..
  8. The IKK/Tpl2 axis of TLR signaling
    Shao Cong Sun; Fiscal Year: 2013
    ..Interestingly, Tpl2 is sequestered by an I(B-like molecule, p105, and the activation of Tpl2 requires IKK-mediated p105 phopshorylation and degradation...
  9. Proliferative Effects of HTLV-1
    Lee Ratner; Fiscal Year: 2013
    ..Aim 3. Which NF?B target genes are critical for HTLV transformation? In this study, shRNAs to NF?B1 (p105) and NF?B2 (p100) are used to assess each individual pathway...
  10. Structure/function of 105-KD basement membrane protein
    Lawrence Chan; Fiscal Year: 2005
    ..We now have the opportunity to discover and understand another previously unknown BMZ component, termed p105, also identified as a result of an autoimmune reaction...
  11. Zinc Deficiency and Thl Functions: Molecular Mechanisms
    Ananda Prasad; Fiscal Year: 2006
    ..activation of IL-2 and IL-2 receptor alpha as affected by zinc will be determined by using antisense p105 expression vector in HUT-78 cells...
  12. Aging /Caloric Restriction /Cytosolic Protease
    Maria Gaczynska; Fiscal Year: 2002
    ..in the cytosolic proteolytic activities influence fidelity of the proteolytic system using the processing of p105 to p50 in NFkB complex as an indicator, its robustness by testing the removal of oxidatively damaged proteins using ..
  13. Inflammatory regulation of lipid accumulation in skeletal muscle with obesity
    Matthew Hulver; Fiscal Year: 2007
    ..Specific Aim 2 proposes the use of TLR4 mutant (C3H/HeJ) and NF-kB knockout (nfkbl -p105) animals to demonstrate that both TLR4 and NF-kB are critically important for SCD1 regulation...
  14. ATRIAL MYOCYTE FUNCTION--STRETCH AND THE CAVEOLAE
    ERNEST PAGE; Fiscal Year: 2001
    ....
  15. Intercellular Communications in Hepatic Function
    Sangeeta Bhatia; Fiscal Year: 2006
    ..abstract_text> ..
  16. Bladder transcriptome in experimental inflammation
    Ricardo Saban; Fiscal Year: 2007
    ..genes expressed specifically on endothelial cells (Tie2-LacZ) and on promoter elements responsive to NFkappaB (p105-LacZ and p65-LacZ) will be used to address our hypothesis...
  17. Aspirin use, genetic variation in aspirin related-genes, and Hodgkin lymphoma ris
    Ellen Chang; Fiscal Year: 2007
    ..Our specific aims are to answer whether genetic variation in 1.) NFKB1/p105, NFKBIA, and/or IKKA/CHUK (genes involved in NF-kB activation and inhibition); 2...
  18. RADIATION AND DRUG EFFECTS ON TUMOR CELL SUBPOPULATIONS
    Dietmar Siemann; Fiscal Year: 2001
    ..In human tumor cells, FlTC conjugated anti-Ki-67 and anti-p105 antibodies and flow cytometry will be used to determine the percentage of proliferating cells...
  19. T-cadherin as an Acrp30/Adiponectin Receptor
    Christopher Hug; Fiscal Year: 2009
    ..As part of this proposal, and working with the basic science sponsors, the applicant will receive training in molecular and cellular biology in order to gain the requisite skills and knowledge to become an independent investigator. ..
  20. NF-KB SIGNAL TRANSDUCTION IN BRAIN INJURY
    KEITH PENNYPACKER; Fiscal Year: 2003
    ..NF-kB in neuronal survival in hippocampus after injury will be discerned by blocking NF-kB transcription using p50 (p105) gene knockout mice and aspirin treatment...
  21. The effects of adiponectin on liver insulin resistance
    Terry Combs; Fiscal Year: 2008
    ..The insight we gain could lead to a better understanding of adiponectin action in the liver and more effective interventions for the treatment of insulin resistance.[unreadable] [unreadable] [unreadable]..
  22. PROTEIN 4.1 TUMOR SUPPRESSORS IN MENINGIOMA PATHOGENESIS
    David Gutmann; Fiscal Year: 2003
    ..and (3) analyzing the ability of DAL-1 to impair cell growth and motility. These studies are collectively designed to define the role of this novel family of growth regulators in meningioma tumorigenesis and progression. ..
  23. The Regulation ACRP30 and Adult Reproductive Development
    Terry Combs; Fiscal Year: 2003
    ..Accelerating or delaying the onset of adulthood by regulating the rise of ACRP3O during puberty might identify a novel role for ACRP3O in reproductive development. ..
  24. FUNCTIONAL ANALYSIS OF NF2 GENE MUTATIONS
    David Gutmann; Fiscal Year: 2003
    ..Our ability to design rational therapies for schwannomas and meningiomas is dependent on an improved understanding of the mechanisms by which loss of merlin expression and function promotes tumor formation. ..
  25. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..
  26. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..These studies will elucidate the mechanisms by which NF kappa B provides protection against apoptosis in response to oncogenic Ras and will potentially provide new insight into the development of anticancer therapies. ..
  27. NEUROFIBROMIN AS A NEGATIVE REGULATOR FOR ASTROCYTES
    David Gutmann; Fiscal Year: 2002
    ....
  28. Molecular Determinants of Neural Stem Cell Function
    David Gutmann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. PRECLINICAL MODELS FOR HUMAN ASTROCYTOMAS
    David Gutmann; Fiscal Year: 2004
    ..abstract_text> ..
  30. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  31. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  32. NQ01, Oxidative Stress and Proteasomal Inhibition
    David Ross; Fiscal Year: 2006
    ..The ability of mutant NQO1 *2 protein to generate oxygen radicals becomes particularly important under conditions where the UPS is inhibited and the protein accumulates. ..
  33. Preventing choroidal neovascularization by long-term transscleral drug delivery
    PURAN BORA; Fiscal Year: 2006
    ..For proof-of-concept, we will use a novel, human protein-based therapy that has shown great potential in preliminary animal studies. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. Neurofibromatosis Foundation International Consortium
    David Gutmann; Fiscal Year: 2003
    ..abstract_text> ..
  35. NQO1 in Protection Against Benzene Toxicicity
    David Ross; Fiscal Year: 2007
    ..abstract_text> ..
  36. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2007
    ..abstract_text> ..
  37. A model of obesity-associated severe acute pancreatitis
    Giamila Fantuzzi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. Identification and Preclinical Evaluation of New Brain Tumor Therapies
    David Gutmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Role of Leptin in murine modeles of IBD
    Giamila Fantuzzi; Fiscal Year: 2007
    ..The possible participation of immune-derived leptin in the local inflammatory network will also be investigated. ..
  40. NQO1 Inhibitors and Pancreatic Cancer Therapy
    David Ross; Fiscal Year: 2008
    ..This approach represents a novel therapeutic strategy for the treatment of pancreatic cancer, a disease where therapeutic options are very limited and where chemotherapy has made minimal impact. ..