T

Summary

Gene Symbol: T
Description: T brachyury transcription factor
Alias: SAVA, TFT, brachyury protein, T, brachyury homolog, protein T
Species: human

Top Publications

  1. ncbi The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27
    Y H Edwards
    Human Biochemical Genetics Unit, University College London, England
    Genome Res 6:226-33. 1996
  2. doi Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, UK
    Am J Surg Pathol 32:572-80. 2008
  3. pmc Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis
    Gerard J Oakley
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:1461-9. 2008
  4. doi Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases
    Nirmala A Jambhekar
    Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
    Arch Pathol Lab Med 134:1181-7. 2010
  5. doi Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 24:425-9. 2011
  6. doi BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
    Debalina Sarkar
    North West Cancer Research Fund Institute, School of Biological Sciences, Bangor University, Bangor, Gwynedd, United Kingdom
    Int J Cancer 130:328-37. 2012
  7. doi Expression of brachyury in hemangioblastoma: potential use in differential diagnosis
    Valeria Barresi
    Department of Human Pathology, University of Messina, Messina, Italy
    Am J Surg Pathol 36:1052-7. 2012
  8. pmc Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
    Mario Roselli
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
    Clin Cancer Res 18:3868-79. 2012
  9. doi Recurrent skeletal extra-axial chordoma confirmed with brachyury: imaging features and review of the literature
    Joshua E Lantos
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Skeletal Radiol 42:1451-9. 2013
  10. doi Evaluation of performance and microbial ecology of sequencing batch reactor and membrane bioreactor treating thin-film transistor liquid crystal display wastewater
    Y J Wu
    Department of Environmental Engineering, Sustainable Environment Research Center SERC, National Cheng Kung University, Tainan, Chinese Taiwan
    Water Sci Technol 58:1085-93. 2008

Research Grants

  1. Digital x-ray imaged based on Hgl2 polycrystalline films
    JAN IWANCZYK; Fiscal Year: 2002
  2. Song Guo Zheng; Fiscal Year: 2016
  3. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
  4. T cell activation requirement in autoimmune demyelination
    Michael K Racke; Fiscal Year: 2010
  5. LAURIE HOLLIS GLIMCHER; Fiscal Year: 2015
  6. AMY SUSAN WEINMANN; Fiscal Year: 2016
  7. T-bet and the Th1/Th17 balance in Acute HIV infection
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2011
  8. Development of CMV-specific T Cell Memory in Lung Transplant Recipients
    John F McDyer; Fiscal Year: 2012
  9. Keith A Choate; Fiscal Year: 2015
  10. Molecular Characterization of T-bet's Role in Immunity
    AMY WEINMANN; Fiscal Year: 2009

Detail Information

Publications203 found, 100 shown here

  1. ncbi The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27
    Y H Edwards
    Human Biochemical Genetics Unit, University College London, England
    Genome Res 6:226-33. 1996
    We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates...
  2. doi Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue
    Roberto Tirabosco
    Department of Histopathology, The Royal National Orthopaedic Hospital, UK
    Am J Surg Pathol 32:572-80. 2008
    ....
  3. pmc Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis
    Gerard J Oakley
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Mod Pathol 21:1461-9. 2008
    ..Podoplanin still remains the only positive marker for chondrosarcoma, though its accuracy is less than previously reported...
  4. doi Revisiting chordoma with brachyury, a "new age" marker: analysis of a validation study on 51 cases
    Nirmala A Jambhekar
    Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India
    Arch Pathol Lab Med 134:1181-7. 2010
    ..At times, it presents a diagnostic challenge, especially in small biopsies. Brachyury, a nuclear transcription factor, is a recently described immunohistochemical marker for diagnosing chordomas...
  5. doi Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 24:425-9. 2011
    ..This study confirms the specificity of brachyury for chordoma in the differential diagnostic distinction from the potential genitourinary mimics, germ cell tumors and metastatic clear cell renal cell carcinoma...
  6. doi BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells
    Debalina Sarkar
    North West Cancer Research Fund Institute, School of Biological Sciences, Bangor University, Bangor, Gwynedd, United Kingdom
    Int J Cancer 130:328-37. 2012
    ..We suggest that BRACHYURY may regulate NANOG in mesenchymal-like CRC cells to impose a 'plastic-state', allowing competence of cells to respond to signals prompting invasion or metastasis...
  7. doi Expression of brachyury in hemangioblastoma: potential use in differential diagnosis
    Valeria Barresi
    Department of Human Pathology, University of Messina, Messina, Italy
    Am J Surg Pathol 36:1052-7. 2012
    ..In the present study we evaluated the potential use of the immunohistochemical evaluation of brachyury protein in the differential diagnosis of these lesions...
  8. pmc Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
    Mario Roselli
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
    Clin Cancer Res 18:3868-79. 2012
    ..The T-box transcription factor Brachyury has been recently characterized as a driver of EMT in human carcinoma cells...
  9. doi Recurrent skeletal extra-axial chordoma confirmed with brachyury: imaging features and review of the literature
    Joshua E Lantos
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Skeletal Radiol 42:1451-9. 2013
    ..We report two cases of recurrent EAC confirmed by the expression of brachyury arising from the distal femur and distal tibia and describe the imaging findings from radiography and MRI at initial diagnosis and at recurrence. ..
  10. doi Evaluation of performance and microbial ecology of sequencing batch reactor and membrane bioreactor treating thin-film transistor liquid crystal display wastewater
    Y J Wu
    Department of Environmental Engineering, Sustainable Environment Research Center SERC, National Cheng Kung University, Tainan, Chinese Taiwan
    Water Sci Technol 58:1085-93. 2008
    In Taiwan, a substantial amount of thin-film transistor liquid crystal display (TFT-LCD) wastewater is produced daily due to an increasing production of the opto-electronic industry in recent years...
  11. pmc Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: evaluation of their utility in treating ocular HSV infections
    Suresh Katragadda
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, United States
    Int J Pharm 359:15-24. 2008
    ..To evaluate in vivo corneal absorption of the amino acid prodrugs of acyclovir (ACV) using a topical well model and microdialysis in rabbits...
  12. pmc Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity
    M de Bruin
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Br J Cancer 88:957-64. 2003
    ..5'DFUR) and possibly 5-fluorouracil (5FU) and Ftorafur (Ft), but inactivates trifluorothymidine (TFT)...
  13. ncbi Hair loss in children in South-East Nigeria: common and uncommon cases
    Edith N Nnoruka
    Sub Department of Dermatology, College of Medicine, and Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
    Int J Dermatol 46:18-22. 2007
    ..This variable pattern of hair loss is seen in all regions, possibly based on the ethnic origin of hair types...
  14. ncbi Thought Field Therapy clinical applications: utilization in an HMO in behavioral medicine and behavioral health services
    C Sakai
    Kaiser Behavioral Medicine and Behavioral Health Services, Honolulu, HI 96814, USA
    J Clin Psychol 57:1215-27. 2001
    Thought Field Therapy (TFT) is a self-administered treatment developed by psychologist Roger Callahan...
  15. ncbi A method to distinguish between the de novo induction of thymidine kinase mutants and the selection of pre-existing thymidine kinase mutants in the mouse lymphoma assay
    Jianyong Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mutat Res 626:185-90. 2007
    ..Trifluorothymidine (TFT), a thymidine analogue and the selection agent normally used in the MLA, and 4-nitroquinoline-1-oxide (4-NQO), a ..
  16. pmc Active pixel imagers incorporating pixel-level amplifiers based on polycrystalline-silicon thin-film transistors
    Youcef El-Mohri
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 USA
    Med Phys 36:3340-55. 2009
    ..Compared to a-Si, poly-Si offers substantially higher mobilities, enabling higher TFT currents and the possibility of sophisticated AP designs based on both n- and p-channel TFTs...
  17. doi Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives
    Erik De Clercq
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Med Res Rev 29:611-45. 2009
    ..e. IDU, TFT) for the treatment of herpes simplex virus (HSV) infections; (vi) acyclic guanosine analogues (e.g...
  18. ncbi Physical and psychophysical characterization of a novel clinical system for digital mammography
    Stefano Rivetti
    Department of Physics, Alma Mater Studiorum, University of Bologna, Bologna 40127, Italy
    Med Phys 36:5139-48. 2009
    ..In these detectors the readout is usually achieved through arrays of thin film transistors (TFTs). However, TFT readout tends to display noise characteristics worse than those from indirect detectors...
  19. ncbi p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells
    S M Morris
    Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    Mutat Res 405:41-56. 1998
    ..tk) locus (both the normal-growth and slow-growth phenotypes) was determined by resistance to trifluorothymidine (TFT) and at the hypoxanthine phosphoribosyl transferase (hprt) locus by resistance to 6-thioguanine (6-TG)...
  20. ncbi Clinical and microbiological features of dientamoebiasis in patients suspected of suffering from a parasitic gastrointestinal illness: a comparison of Dientamoeba fragilis and Giardia lamblia infections
    Olivier Vandenberg
    Department of Microbiology, Saint Pierre University Hospital, Brussels, Belgium
    Int J Infect Dis 10:255-61. 2006
    ..To describe the clinical and microbiological features of Dientamoeba fragilis and Giardia lamblia infected patients, and to analyze the genetic variation of D. fragilis strains...
  21. doi Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia
    Stefano Molica
    Medical Oncology Unit, Hematology Oncology Department, Azienda Ospedaliera Pugliese Ciaccio, Viale Pio X 88100 Catanzaro, Italy
    Eur J Haematol 83:208-14. 2009
    ..CD26 (dipeptidyl peptidase IV, DPP IV) by evaluating the impact of these variables on the time to first treatment (TFT) in a series of 69 previously untreated Binet stage A B-cell CLL patients...
  22. doi Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia
    Stefano Molica
    Medical Oncology Unit, Hematology Oncology Department, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Eur J Haematol 85:314-20. 2010
    ..factor (BAFF of the TNF family) by evaluating the impact of these variables on the time to first treatment (TFT) in a series of 169 previously untreated CLL patients in Binet stage A...
  23. ncbi Emergence of cross-resistant herpes simplex virus following topical drug therapy in rabbit keratitis
    C Fardeau
    , INSERM U 86, , Paris, France
    Curr Eye Res 10:151-8. 1991
    ..virus (HSV-1) in rabbit cornea treated with either IUdR (idoxuridine), IDC (idoxycytidine), ACV (acyclovir), TFT (trifluridine), or Ara A (adenine arabinoside)...
  24. ncbi Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study
    D L Williams
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    Curr Eye Res 29:215-8. 2004
    ..To determine, by a plaque reduction assay, the in vitro efficacy of novel antiviral agents in the treatment of feline herpes virus 1 (FHV-1) keratitis in the domestic cat (Felis felis)...
  25. doi Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene mutation status as a predictor of time to first treatment in early chronic lymphocytic leukemia
    Stefano Molica
    Department of Oncology Hematology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Leuk Lymphoma 49:62-7. 2008
    ..according to known and putative prognostic parameters was also evaluated as time to first treatment (TFT). The univariate Cox proportional hazard model demonstrated that the absence of IgV(H) mutational status (p = 0...
  26. pmc Crohn's disease--defect in innate defence
    Michael Gersemann
    Internal Medicine I, Robert Bosch Hospital, Auerbachstrasse 110, Stuttgart, Germany
    World J Gastroenterol 14:5499-503. 2008
    ..Crohn's ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation...
  27. pmc Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet
    Kasi McCune
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 70:685-96. 2010
    ..The transcription factor T-bet is a negative regulator of GATA-3 in the immune system...
  28. ncbi Additive noise properties of active matrix flat-panel imagers
    M Maolinbay
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109, USA
    Med Phys 27:1841-54. 2000
    ..Pixel noise is further divided into the following components: TFT thermal noise, shot and 1/f noise associated with the TFT and photodiode leakage currents, and TFT transient noise...
  29. ncbi Quantitative SIMS depth profiling of diffusion barrier gate-oxynitride structures in TFT-LCDs
    Sabine Dreer
    Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9 164 AC, 1060 Vienna, Austria
    Anal Bioanal Chem 379:599-604. 2004
    Gate oxynitride structures of TFT-LCDs were investigated by SIMS, and successful solutions are demonstrated to overcome difficulties arising due to the charging effects of the multilayer systems, the matrix effect of the method, and the ..
  30. doi Biological treatment of thin-film transistor liquid crystal display (TFT-LCD) wastewater
    C N Lei
    Department of Environmental Engineering, Sustainable Environment Research Center SERC, National Cheng Kung University, Tainan, Chinese Taiwan
    Water Sci Technol 58:1001-6. 2008
    The amount of pollutants produced during manufacturing processes of TFT-LCD (thin-film transistor liquid crystal display) substantially increases due to an increasing production of the opto-electronic industry in Taiwan...
  31. ncbi Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic periodontitis
    Nicolas Dutzan
    Periodontal Biology Laboratory, Department of Conservative Dentistry, Dentistry Faculty, University of Chile, Santiago, Chile
    J Periodontol 80:290-6. 2009
    ..During the generation of a primary CD4(+) T helper 1 (Th1) response, interferon-gamma (IFN-gamma) acts as a positive regulator by selectively inducing Th1 ..
  32. pmc Scan equalization digital radiography (SEDR) implemented with an amorphous selenium flat-panel detector: initial experience
    Xinming Liu
    Department of Imaging Physics, Digital Imaging Research Laboratory, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Phys Med Biol 54:6959-78. 2009
    ..equalization digital radiography (SEDR) system implemented with an amorphous silicon (a-Si) thin-film transistor (TFT) array-based flat-panel detector...
  33. ncbi Comparison of HSV-1 thymidine kinase-dependent and -independent inhibition of replication-competent adenoviral vectors by a panel of drugs
    Oliver Wildner
    Ruhr Universitat Bochum, Abteilung für Molekulare und Medizinische Virologie, Bldg MA, Rm 6 40, D 44801 Bochum, Germany
    Cancer Gene Ther 10:791-802. 2003
    ..the fluorinated pyrimidine analogs 5-fluoro-2'-deoxyuridine (FUdR), 5-fluorouridine (FUR), and trifluorothymidine (TFT), with a mean 50% inhibitory concentration (IC(50)) ranging from 0.12 to 0.32 microM...
  34. pmc Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells
    O H Temmink
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 96:231-40. 2007
    ..The pyrimidine analog trifluorothymidine (TFT) forms together with a thymidine phosphorylase inhibitor (TPI) the anticancer drug formulation TAS-102, in which ..
  35. pmc Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model
    Motonobu Nakamura
    Department of Dermatology, Gunma University, Maebashi, Japan
    Am J Pathol 172:650-8. 2008
    ..Here we confirmed that infiltrating CD4 T lymphocytes around hair follicles of patients with alopecia areata were primarily CCR5-positive with few CCR4-..
  36. doi Diagnosing unsuspected hypopituitarism in adults from suggestive thyroid function test results
    David Preiss
    Department of Biochemistry, Glasgow Royal Infirmary, Castle Street, Glasgow, UK
    Ann Clin Biochem 45:70-5. 2008
    ..2 cases/100,000/year by following up abnormal TFTs. The aim of this study was to verify the incidence of unsuspected hypopituitarism diagnosed by reflective testing on such samples in a Scottish population...
  37. ncbi Triple Faeces Test: an effective tool for detection of intestinal parasites in routine clinical practice
    T van Gool
    Section of Parasitology, Department of Medical Microbiology, L1 110, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 22:284-90. 2003
    ..The results of the test, called the "Triple Faeces Test" (TFT), were compared with those of the conventional diagnostic method, i.e...
  38. pmc T-bet is required for protection against vaccinia virus infection
    Masanori Matsui
    Department of Microbiology, Saitama Medical School, Moroyama cho, Iruma gun, Japan
    J Virol 79:12798-806. 2005
    The transcription factor T-bet regulates the differentiation of CD4(+) T-helper type 1 (Th1) cells and represses Th2 lineage commitment...
  39. ncbi [Pyrolysis characteristics of medical waste compositions containing PVC (polyvinyl chloride)]
    Na Deng
    School of Environmental Science and Engineering, Tianjin Uninversity, Tianjin 300072, China
    Huan Jing Ke Xue 29:837-43. 2008
    ..of medical waste compositions containing PVC (polyvinyl chloride), thermogravimetric study of tube for transfusion (TFT) and sample collector for urine (SCFU) was carried out using the thermogravimetric analyser (TGA) with N2...
  40. doi Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies
    Jagadeesh Bayry
    Institut National de la Santé et de la Recherche Médicale Unité 872, F 75006 Paris, France
    J Autoimmun 36:9-15. 2011
    ..stimulation by IVIg is not associated with induction of B cell effector cytokine IFN-γ and of transcription factor T-bet...
  41. ncbi Children's immunology, what can we learn from animal studies (2): Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and toll-like receptor (TLR) 2 ligand
    Shoji Yamamoto
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Toxicol Sci 34:SP341-8. 2009
    ..On the other hand, splenic expression of transcription factor T-bet (Th1-specific), GATA-3 (Th2-specific) and Foxp3 (gene marker for regulatory CD4+CD25+ T-cells) mRNAs was ..
  42. ncbi Heterogeneity stabilizes reciprocal altruism interactions
    M A Fishman
    Department of Zoology, Tel Aviv University, Tel Aviv, 69978, Israel
    J Theor Biol 209:87-95. 2001
    ..Furthermore, this cooperation is implemented via unmodified tit-for-tat (TfT) strategy...
  43. ncbi T-bet transcription factor detection facilitates the diagnosis of minimal hairy cell leukemia infiltrates in bone marrow trephines
    Korinna Johrens
    Consultation and Reference Center for Hematopathology at the Institute of Pathology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Germany
    Am J Surg Pathol 31:1181-5. 2007
    ..Among the antibodies tested those directed against the T-cell associated transcription factor T-bet showed the required specificity: (1) T-bet is highly expressed in all 85 ..
  44. pmc IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infection
    Sara L Colpitts
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 182:5702-11. 2009
    ..Our laboratory has described two populations of Leishmania-induced CD4(+) T cells that contribute to immunity: CD62L(high) central memory T (T(CM)) cells and CD62L(low) effector T cells...
  45. ncbi Potential for medical error: incorrectly completed request forms for thyroid function tests limit pathologists' advice to clinicians
    Annalise E Zemlin
    Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:668-71. 2009
    ..Interpretative comments are added to all TFT results.
  46. ncbi Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression
    Hong Ren Yu
    Division of Clinical Immunology and Allergy, Chang Gung Children s Hospital, Chang Gung University, Kaohsiung, Taiwan, ROC
    J Leukoc Biol 74:952-8. 2003
    ..Th1/Th2 reactions as demonstrated by IL-4/IFNgamma production and mRNA expression, and transcriptional factors T-bet/GATA-3 mRNA expression in mononuclear cells from human umbilical cord blood (CBMC)...
  47. ncbi Synergistic inhibition of herpesvirus replication by docosanol and antiviral nucleoside analogs
    John F Marcelletti
    Avanir Pharmaceuticals, 11388 Sorrento Valley Road, Suite 200, San Diego, CA 92121, USA
    Antiviral Res 56:153-66. 2002
    ..intensified the inhibition of HSV production by all tested nucleoside analogs, including trifluorothymidine (TFT), adenine arabinoside (Ara-A), and ribavirin...
  48. doi Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells
    Irene V Bijnsdorp
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 126:2457-68. 2010
    Trifluorothymidine (TFT) is part of the oral drug formulation TAS-102. Both 5-fluorouracil (5-FU) and TFT can inhibit thymidylate synthase and be incorporated into DNA. TFT shows only moderate cross-resistance to 5-FU...
  49. doi When should we be conducting thyroid function tests in newborns and young infants?
    Michael O Ogundele
    Department of Paediatrics, Royal United Hospital Bath NHS Trust, Combe Park, Bath BA1 3NG, UK
    Arch Dis Child 95:151-2. 2010
    An audit of local practice was undertaken as regards requests for thyroid function tests (TFT) in children aged between birth and 3 months at two local hospitals in South West England between 2005 and 2008...
  50. doi The utilization of thin film transistor liquid crystal display waste glass as a pozzolanic material
    K L Lin
    Department of Environmental Engineering, National Ilan University 1, Section 1, Shen Lung Road, Yi Lan City 26047, Taiwan, ROC
    J Hazard Mater 163:916-21. 2009
    ..behavior of waste glass blended cement (WGBC) paste used in thin film transistor liquid crystal displays (TFT-LCD). X-ray diffraction (XRD) results demonstrate that the TFT-LCD waste glass was entirely non-crystalline...
  51. ncbi Influence of room lighting on grey-scale perception with a CRT-and a TFT monitor display
    R Haak
    Department of Operative Dentistry and Periodontology, University of Cologne, Koln, Germany
    Dentomaxillofac Radiol 31:193-7. 2002
    To determine the influence of ambient lighting on grey-scale perception using a cathode-ray tube (CRT) and a thin film transistor (TFT) computer display.
  52. ncbi Improvement of routine diagnosis of intestinal parasites with multiple sampling and SAF-fixative in the triple-faeces-test
    Olivier Vandenberg
    Department of Microbiology, Saint Pierre University Hospital, Brussels, Belgium
    Acta Gastroenterol Belg 69:361-6. 2006
    ..With application of the Triple-Faeces-Test (TFT) protocol, where both multiple sampling and a SAF-fixative are included, these practical problems could be overcome...
  53. doi Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa
    A Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts, London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK
    Gut 57:605-12. 2008
    The role of transforming growth factor beta (TGFbeta) in inhibiting T cell function in the normal gut has been studied in animal models...
  54. pmc Simple and rapid enzymatic method for the synthesis of single-strand oligonucleotides containing trifluorothymidine
    Norihiko Suzuki
    Tokushima Research Center, Taiho Pharmaceutical Co Ltd, 224 2 Hiraishi Ebisuno, Kawauchi, Tokushima, Japan
    Nucleosides Nucleotides Nucleic Acids 29:896-904. 2010
    To investigate the mechanism of trifluorothymidine (TFT)-induced DNA damage, we developed an enzymatic method for the synthesis of single-strand oligonucleotides containing TFT-monophosphate residues...
  55. pmc The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells
    O H Temmink
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 96:61-6. 2007
    ..TAS-102 is a new oral drug formulation, which is composed of trifluorothymidine (TFT) and thymidine phosphorylase inhibitor (TPI), which prevents TFT degradation...
  56. ncbi The search for the holy grail: heart rate variability and thought field therapy
    J D Herbert
    Department of Clinical and Health Psychology, MCP Hahnemann University, Philadelphia, PA 19102 1192, USA
    J Clin Psychol 57:1207-14. 2001
    Thought Field Therapy (TFT) is one of several unusual psychotherapies that have witnessed rapid growth over the past few years, despite the absence of scientific support...
  57. ncbi Management of acyclovir-resistant herpes simplex virus
    Suneel Chilukuri
    Department of Dermatology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Dermatol Clin 21:311-20. 2003
    ..If the mucocutaneous lesion is accessible for topical treatment, TFT (as ophthalmic solution) should be applied to the area three to four times a day until the lesion is completely ..
  58. pmc IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    Sophie Lucas
    Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:15047-52. 2003
    IL-27, a novel heterodimeric cytokine produced by antigen-presenting cells, signals through the T cell cytokine receptor (TCCR)/WSX-1 expressed on naïve CD4+ T cells and natural killer cells...
  59. ncbi Effect of video display on the grading of diabetic retinopathy
    M T J Costen
    Southampton Eye Unit, Southampton General Hospital, Tremona Road, Southampton, UK
    Eye (Lond) 18:169-74. 2004
    Digital images are increasingly being used in ophthalmology. These may be viewed either on thin-film transistor (TFT) or on cathode-ray tube (CRT) displays. However, there is little data showing which is superior...
  60. ncbi Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    UGRP1 is a downstream target gene for homeodomain transcription factor T/EBP/NKX2.1, which is predominantly expressed in lung epithelial cells, and may play an anti-inflammatory role in lung inflammation...
  61. ncbi Regarding the October 2001 Journal of Clinical Psychology special issue on Thought Field Therapy: retraction of conclusions in the article "heart rate variability as an outcome measure for Thought Field Therapy in clinical practice"
    Monica Pignotti
    Independent Scholar
    J Clin Psychol 61:361-5; discussion 367-72. 2005
    ..published as part of a special October 2001 issue of the Journal of Clinical Psychology on Thought Field Therapy (TFT). I decided to write this retraction after reconsidering a number of issues raised in the critiques of the articles...
  62. ncbi A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment
    Amr El-Sheikh
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 65:11109-17. 2005
    ..t blood vessels. Here, we have coupled the HBDt to the extracellular domain of tissue factor (TFt), to locally initiate the thrombogenic cascade. In tumor-bearing mice, infusion of this HBDt...
  63. ncbi Relationships between central tear film thickness and tear menisci of the upper and lower eyelids
    Jianhua Wang
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 47:4349-55. 2006
    To investigate the relationship between central tear film thickness (TFT) and tear menisci of the upper and lower eyelids using real-time optical coherence tomography (OCT).
  64. ncbi Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet
    Gabriella Lakos
    Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 2909, USA
    Pathobiology 73:224-37. 2006
    ..skin fibrosis as a murine model for human scleroderma in order to study the fibrotic response in mice lacking T-bet, a transcription factor that is essential for initiating Th1 lineage development of CD4+ T lymphocytes...
  65. ncbi Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    Denise C Fitzgerald
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Immunol 8:1372-9. 2007
    ..Here we report that IL-27 upregulated IL-10 in effector T cells that produced interferon-gamma and expressed the transcription factor T-bet but did not express the ..
  66. ncbi Brightness discrimination in the harbor seal (Phoca vitulina)
    Christine Scholtyssek
    General Zoology and Neurobiology, University of Bochum, ND 6 33, D 44780 Bochum, Germany
    Vision Res 48:96-103. 2008
    ..9lx. The visual stimuli consisted of circular gray discs that were presented on a black background on a TFT monitor. Eight standard intensities were tested against sets of lower comparison intensities...
  67. doi Requirements for the natural killer cell-mediated induction of IgG1 and IgG2a expression in B lymphocytes
    Ning Gao
    Laboratory of Molecular Pathology, Department of Molecular Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 20:645-57. 2008
    ..In addition, NK cells can also upregulate mRNA for the T-box transcription factor (T-bet) in B cells without being able to induce further differentiation...
  68. pmc Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
    Megan F Cole
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 22:746-55. 2008
    ..We report here that a terminal component of the canonical Wnt pathway in ES cells, the transcription factor T-cell factor-3 (Tcf3), co-occupies promoters throughout the genome in association with the pluripotency regulators ..
  69. doi Microbial ecology and performance of nitrifying bacteria in an aerobic membrane bioreactor treating thin-film transistor liquid crystal display wastewater
    L M Whang
    Department of Environmental Engineering, National Cheng Kung University, Tainan, Chinese Taiwan
    Water Sci Technol 58:2365-71. 2008
    This study was conducted to evaluate the long-term performance of an aerobic membrane bioreactor (MBR), treating TFT-LCD wastewater containing dimethyl sulphoxide (DMSO), monoethanolamine (MEA) and tetra-methyl ammonium hydroxide (TMAH), ..
  70. ncbi Charge conduction and breakdown mechanisms in self-assembled nanodielectrics
    Sara A DiBenedetto
    Department of Chemistry and the Materials Research Center, Northwestern University, Evanston, Illinois 60208 3113
    J Am Chem Soc 131:7158-68. 2009
    ..robust films with excellent insulating and surface passivation properties, enhancing both organic and inorganic TFT performance and lowering device operating voltages...
  71. doi Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2
    Olaf H Temmink
    Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cancer Ther 9:1047-57. 2010
    Trifluorothymidine (TFT) is part of the novel oral formulation TAS-102, which is currently evaluated in phase II studies. Drug resistance is an important limitation of cancer therapy...
  72. pmc In vitro synergism of trifluorothymidine and ganciclovir against HSV-1
    Jeffery A Hobden
    Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Invest Ophthalmol Vis Sci 52:830-3. 2011
    To determine whether trifluorothymidine (TFT) and ganciclovir (GCV) are synergistic against herpes simplex virus type 1 (HSV-1).
  73. ncbi Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduated School of Dentistry, Suita, Osaka 565 0871, Japan
    Int J Oncol 37:1095-103. 2010
    ..form was enhanced in these cells which could be demonstrated by an elevated level of the transcription factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-dependent reporter gene activity as well as by the up-regulation of ..
  74. ncbi Self-organized criticality as Witten-type topological field theory with spontaneously broken Becchi-Rouet-Stora-Tyutin symmetry
    Igor V Ovchinnikov
    Department of Electrical Engineering, University of California at Los Angeles, Los Angeles, California 90095 1594, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051129. 2011
    ..a generic self-organized critical (SOC) system can be looked upon as a Witten-type topological field theory (W-TFT) with spontaneously broken Becchi-Rouet-Stora-Tyutin (BRST) symmetry...
  75. doi Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway
    Yuedan Zhou
    Department of Clinical Sciences, CRC, Lund University, Malmo 20502, Sweden
    Hum Mol Genet 21:196-207. 2012
    The transcription factor T-cell factor 7-like 2 (TCF7L2) confers type 2 diabetes risk mainly through impaired insulin secretion, perturbed incretin effect and reduced beta-cell survival...
  76. doi Correlation between thyroid autoantibodies and intracranial arterial stenosis in stroke patients with hyperthyroidism
    Xuting Zhang
    Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China
    J Neurol Sci 318:82-4. 2012
    ..We also compared the baseline characteristics, thyroid function test (TFT), and prevalence of intracranial arterial stenosis between patients with or without elevated TPO-Ab level...
  77. doi Three-finger toxins, a deadly weapon of elapid venom--milestones of discovery
    Yuri N Utkin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, RAS, ul Miklukho Maklaya 16 10, Moscow 117997, Russia
    Toxicon 62:50-5. 2013
    ..The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the study of ..
  78. doi A common single-nucleotide variant in T is strongly associated with chordoma
    Nischalan Pillay
    Cancer Institute, University College London, UK
    Nat Genet 44:1185-7. 2012
    Chordoma is a rare malignant bone tumor that expresses the transcription factor T. We conducted an association study of 40 individuals with chordoma and 358 ancestry-matched controls, with replication in an independent cohort...
  79. doi Surface modification of a polyimide gate insulator with an yttrium oxide interlayer for aqueous-solution-processed ZnO thin-film transistors
    Kwang Suk Jang
    Division of Advanced Materials, Korea Research Institute of Chemical Technology, Daejeon 305 600, Republic of Korea
    Langmuir 29:7143-50. 2013
    ..The field-effect mobility and the on/off current ratio of the ZnO TFT with the YOx/polyimide gate insulator were 0.456 cm(2)/V·s and 2...
  80. doi Damage-free back channel wet-etch process in amorphous indium-zinc-oxide thin-film transistors using a carbon-nanofilm barrier layer
    Dongxiang Luo
    Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, P R China
    ACS Appl Mater Interfaces 6:11318-25. 2014
    ..The TFT device with a 3 nm-thick C barrier layer showed a saturated field effect mobility of 14...
  81. doi Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma
    Michael J Kelley
    Department of Medicine, Duke University Medical Center, Durham, NC, 27705, USA
    Hum Genet 133:1289-97. 2014
    ..We previously identified germline T duplication as a major susceptibility mechanism in several chordoma families...
  82. doi Thalassemias and hemoglobinopathies in Turkey
    Duran Canatan
    Mediterranean Blood Diseases Foundation, Antalya, Turkey
    Hemoglobin 38:305-7. 2014
    ..of Health (MOH), the Turkish National Hemoglobinopathy Council (TNHC) and the Thalassemia Federation of Turkey (TFT) since 2000...
  83. doi Mechanistic aspects of thioflavin-T self-aggregation and DNA binding: evidence for dimer attack on DNA grooves
    A Biancardi
    Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    Phys Chem Chem Phys 16:20061-72. 2014
    Thioflavin-T (TFT) is a fluorescent marker widely employed in biomedical research but the mechanism of its binding to polynucleotides has been poorly understood...
  84. doi T Cell factor 1 represses CD8+ effector T cell formation and function
    Machteld M Tiemessen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Immunol 193:5480-7. 2014
    The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8(+) T cells...
  85. doi Unfolding stabilities of two structurally similar proteins as probed by temperature-induced and force-induced molecular dynamics simulations
    Biswajit Gorai
    a Structural Biology Lab, School of Chemical and Biotechnology, Department of Bioinformatics, SASTRA University, Thanjavur 613 401, Tamil Nadu, India
    J Biomol Struct Dyn 33:2037-47. 2015
    ..of two homologous proteins, cardiotoxin III and short-neurotoxin (SNTX) belonging to three-finger toxin (TFT) superfamily, have been probed by means of molecular dynamics (MD) simulations...
  86. doi Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography
    Semira Kaya
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
    Acta Ophthalmol 93:439-43. 2015
    The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects.
  87. pmc The enhanced formaldehyde-sensing properties of P3HT-ZnO hybrid thin film OTFT sensor and further insight into its stability
    Huiling Tai
    State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Information, University of Electronic Science and Technology of China UESTC, Chengdu 610054, China
    Sensors (Basel) 15:2086-103. 2015
    A thin-film transistor (TFT) having an organic-inorganic hybrid thin film combines the advantage of TFT sensors and the enhanced sensing performance of hybrid materials...
  88. doi A case of thyroid hormone resistance: a rare mutation
    Ana Pires Gonçalves
    Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal
    Arq Bras Endocrinol Metabol 58:962-6. 2014
    ..The patient's son underwent thyroid function testing (TFT) and genetic study, both negative, suggesting a sporadic mutation...
  89. doi Tear ferning test in horses and its correlation with ocular surface evaluation
    Laura R Silva
    Veterinary Medicine Department, College of Veterinary Medicine, University of Brasilia, Brasilia, DF, Brazil
    Vet Ophthalmol 19:117-23. 2016
    To describe the tear ferning test (TFT) in healthy horses and its correlation with other parameters for evaluating the ocular surface.
  90. doi The transcriptional programs of iNKT cells
    Edy Y Kim
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 15 Francis Street, Boston, MA 02115, United States Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith Building, 5th Floor, 1 Jimmy Fund Way, Boston, MA 02115, United States Electronic address
    Semin Immunol 27:26-32. 2015
    Invariant natural killer T (iNKT) cells are innate T cells that express a semi-invariant T cell receptor (TCR) and recognize lipid antigens presented by CD1d molecules...
  91. doi Aberrant expression of RUNX3 in patients with immune thrombocytopenia
    Jianlin Qiao
    Department of Hematology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China Blood Diseases Institute, Xuzhou Medical College, Xuzhou 221002, China Key Laboratory of Bone Marrow Stem Cell, Jiangsu Province, Xuzhou 221002, China
    Int Immunopharmacol 28:252-6. 2015
    ..of the runt domain-containing family of transcription factors and plays an important role in the regulation of T cell differentiation into Th1 cells. Whether RUNX3 was involved in the pathogenesis of ITP remains unclear...
  92. doi T gene isoform expression pattern is significantly different between chordomas and notochords
    Ke Wang
    Skull Base and Brainstem Tumor Division, Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing 100050, China China National Clinical Research Center for Neurological Diseases, NCRC ND, Tiantan Xili 6, Dongcheng District, Beijing 100050, China Electronic address
    Biochem Biophys Res Commun 467:261-7. 2015
    The T gene plays a key role in chordoma pathology. To investigate the role of T gene isoforms in chordoma, 22 skull base chordomas, three chordoma cell lines and 9 infant notochords, which were used as normal controls, were collected...
  93. pmc The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection
    Claudia X Dominguez
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520
    J Exp Med 212:2041-56. 2015
    The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during viral ..
  94. doi SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury
    Kaichun Li
    Department of Oncology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, P R China
    Oncol Rep 35:2405-12. 2016
    ..Brachyury is a protein that is encoded by the T gene in humans, which is a transcription factor within the T-box complex of genes...
  95. doi Printed thin film transistors and CMOS inverters based on semiconducting carbon nanotube ink purified by a nonlinear conjugated copolymer
    Wenya Xu
    Printable Electronics Research Centre, Suzhou Institute of Nanotech and nano bionics, Chinese Academy of Sciences, No 398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu Province 215123, PR China
    Nanoscale 8:4588-98. 2016
    ..With the printed TFTs, a CMOS inverter was constructed, which is based on the p-type TFT and ambipolar TFT instead of the conventional p-type and n-type TFTs...
  96. doi Pulse I-V characterization of a nano-crystalline oxide device with sub-gap density of states
    Taeho Kim
    Department of Applied Physics, Korea University, 2511, Sejongro, Sejong, 339 700, Korea
    Nanotechnology 27:215203. 2016
    ..the intrinsic device performance of an amorphous/nano-crystalline indium-hafnium-zinc-oxide semiconductor TFT with varying density of states in the bulk...
  97. doi IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
    Yoichiro Ohne
    Baylor Research Institute, Baylor Scott and White Health, Dallas, Texas, USA
    Nat Immunol 17:646-55. 2016
    ..IL-1β also governed ILC2 plasticity by inducing low expression of the transcription factor T-bet and the cytokine receptor chain IL-12Rβ2, which enabled the conversion of these cells into an ILC1 phenotype in ..
  98. doi A Furan-Thiophene-Based Quinoidal Compound: A New Class of Solution-Processable High-Performance n-Type Organic Semiconductor
    Yu Xiong
    Key Laboratory of Synthetic and Self Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, CAS, Shanghai, 200032, China
    Adv Mater 28:5949-53. 2016
    The furan-thiophene-based quinoidal organic semiconductor, TFT-CN, is designed and synthesized. TFT-CN displays a high electron mobility of 7...
  99. doi RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP)
    Ying Lin
    Department of Hematology, The Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University, Wenzhou, China
    Int Immunopharmacol 38:40-4. 2016
    Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by reduction in platelet counts. T helper 1 (Th1) cells polarization with an increased shift of Th1/Th2 ratio has been reported in ITP...
  100. doi NK cells and type 1 innate lymphoid cells: partners in host defense
    Hergen Spits
    Department of Cell Biology, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Nat Immunol 17:758-64. 2016
    ..characterized by their capacity to produce interferon-γ and their functional dependence on the transcription factor T-bet...
  101. doi The relation between changes in thyroid function and anthropometric indices during long-term follow-up of euthyroid subjects: the Tehran Thyroid Study (TTS)
    Behrang Motamed
    Obesity Research Center
    Eur J Endocrinol 175:247-53. 2016
    Uncertainties exist regarding the causal relationship between thyroid function tests (TFT) within the euthyroid range and anthropometric measures. This longitudinal cohort is aimed to examine the relationship between the two conditions.

Research Grants56

  1. Digital x-ray imaged based on Hgl2 polycrystalline films
    JAN IWANCZYK; Fiscal Year: 2002
    ..on HgI2 polycrystalline films coupled to large area flat panel amorphous silicon (a-Si:H) thin-film transistor (TFT)-addressed readout arrays...
  2. Song Guo Zheng; Fiscal Year: 2016
    ..The current proposal plans to develop a novel approach that tests the central hypothesis: CD4?? regulatory T cells (iTregs) generated with IL-2 and TGF-2 are stable in an inflammatory milieu and are able to treat collagen-..
  3. T-bet regulates CD4 memory to bacterial infection with C. trachomatis
    David Gondek; Fiscal Year: 2010
    ..It is also known that expression of IFN-g by CD4+ T cells, CD8+ T cells, NK cells, and dendritic cells is partially controlled by the transcription factor T-bet...
  4. T cell activation requirement in autoimmune demyelination
    Michael K Racke; Fiscal Year: 2010
    Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated, autoimmune disorder characterized by central nervous system (CNS) inflammation and demyelination, features reminiscent of the human disease, multiple sclerosis (MS)...
  5. LAURIE HOLLIS GLIMCHER; Fiscal Year: 2015
    ..Under the aegis of this grant, we recently described a new model of commensal-dependent ulcerative colitis termed T-bet-/- RAG2-/- Ulcerative Colitis (TRUC) that results from T-bet deficiency in the innate immune system...
  6. AMY SUSAN WEINMANN; Fiscal Year: 2016
    ..In the immune system, naive CD4+ T helper cells begin with the potential to become a number of phenotypically distinct lineages, with key transcription ..
  7. T-bet and the Th1/Th17 balance in Acute HIV infection
    LAURIE HOLLIS GLIMCHER; Fiscal Year: 2011
    ..provided by applicant): Acute HIV infection is accompanied by inflammation and by a profound loss of CD4+ T cells from the gastrointestinal (GI) tract...
  8. Development of CMV-specific T Cell Memory in Lung Transplant Recipients
    John F McDyer; Fiscal Year: 2012
    ..The mechanisms by which D+R- LTRs develop and maintain protective CMV-specific T cell immunity, particularly within the lung allograft, remain incompletely understood...
  9. Keith A Choate; Fiscal Year: 2015
    ..for a functional allele at the thymidine kinase (TK) locus, conferring sensitivity to trifluorothymidine (TFT) and allowing detection of spontaneous and induced LOH events by selection for TFT resistance...
  10. Molecular Characterization of T-bet's Role in Immunity
    AMY WEINMANN; Fiscal Year: 2009
    ..In the immune system, na[unreadable]ve CD4+ T helper cells begin with the potential to become a number of phenotypically distinct lineages, with key transcription ..
  11. Control of Effector and Memory T Cell Development by Inflammatory Signals
    Susan M Kaech; Fiscal Year: 2013
    ..provided by applicant): Immunological memory is a cardinal property of the adaptive immune system and memory CD8 T cells play a critical role in providing long-term protective immunity against reoccurring infectious disease and ..
  12. Mechanisms of Effector CD4 Cell Tolerization
    Adam Adler; Fiscal Year: 2009
    The immune system utilizes a variety of tolerance mechanisms to prevent autoreactive T cells from becoming activated...
  13. ANTIGEN SPECIFIC THERAPY IN CNS AUTOIMMUNE DISEASES
    Howard L Weiner; Fiscal Year: 2010
    ..a program project to investigate the cellular and molecular mechanisms underlying the pathogenicity of autoreactive T cells against myelin and the factors that drive T cells towards a pathogenic or disease protective phenotype...
  14. Infection and CD8 T Cell Memory: Development, Maintenance and Plasticity
    Claudia Dominguez; Fiscal Year: 2011
    ..have often been the focus of vaccination strategies, cell mediated protection, mainly in the form of cytotoxic CD8 T cells, also plays an important role in fighting many infections...
  15. CD8+ Th17 and Costimulation Blockade Resistant Allograft Rejection
    D Keith Bishop; Fiscal Year: 2010
    ..Th responses induced by cardiac transplantation, we observed that mice deficient in the Th1 transcription factor T-bet (T-bet-/-) mount both Th1 and Th17 responses, while wild type (WT) recipients mount only Th1 responses...
  16. The Role of Src Family Kinase Lck in Th2 Differentiation
    KYEORDA KEMP; Fiscal Year: 2009
    The mechanisms controlling T helper differentiation into the Th1 and Th2 lineages are not fully understood. These studies investigate the role of the SRC-family kinase Lck in Th2 differentiation...
  17. Flat-panel X-ray Imaging Detector with Avalanche Gain
    Wei Zhao; Fiscal Year: 2013
    ..optical image to charge and provide a programmable gain;and a large area active matrix (AM) thin film transistor (TFT) array to read out the image electronically in real-time...
  18. High resolution Mammography Sensor
    MICHAEL SQUILLANTE; Fiscal Year: 2009
    ..To utilize HgI2 as an x-ray receptor, it must be coupled with an amorphous silicon (a-Si) thin film transistor (TFT) array. The TFT array provides pixelation, charge storage and frame readout necessary to form a complete imager...
  19. TYMPANIC TEMPERATURE AND SLOW WAVE SLEEP IN HUMANS
    Ralph Berger; Fiscal Year: 1990
    ..Rectal temperature (Tre) and skin temperature of the foot (Tft) will also be recorded. In each of two experiments, nine Ss will be studied, each for eight nights...
  20. DIGITAL X-RAY IMAGERS BASED ON HGI2 POLYCRYSTALLINE FILM
    JAN IWANCZYK; Fiscal Year: 2000
    ..on Hgl2 polycrystalline films coupled to large area fiat panel amorphous silicon (a-Si:H) thin-film transistor (TFT)addressed readout arrays...
  21. c-Ab1 in the allergic inflammatory lung disease
    Deyu Fang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): T helper type 2 (Th2) cells are crucial for causing the allergic inflammatory lung diseases such as asthma, by producing key cytokines, including interleukin (IL)-4, IL-5 and IL-13...
  22. Transciptional Regulation of the Type 1 T Cell Response
    Mark Boothby; Fiscal Year: 2001
    DESCRIPTION: (Provided by the Applicant): The regulation of helper T-cell clonal expansion, and differentiation influences the outcome of infections and the susceptibility to autoimmune diseases...
  23. FAMILY AND GROUP THERAPIES FOR ADOLESCENT ALCOHOL ABUSE
    MORRIS STANTON; Fiscal Year: 2005
    ..One of these is a state-of-the-art family therapy approach, Transitional Family Therapy (TFT), which integrates nuclear family, here-and-now interventions, with multigenerational issues...
  24. Optimized Digital Mammography with an a-Se FP Imager
    Chris Shaw; Fiscal Year: 2007
    ..Digital Mammography (SEDM) system using an amorphous selenium and amorphous silicon thin film transistor (aSe/aSi TFT) array based flat-panel imager as the x-ray detector...
  25. SAMPLE PREPARATION MODULE FOR PLATELET TESTING ON TFT
    Shuqi Chen; Fiscal Year: 2000
    A blood sampling module used with the tubule flow chamber technology (TFT) platform will be developed to create a fully automated sample preparation and testing system for platelet function testing...
  26. DEVELOPMENT OF PLATELET FUNCTION TESTING ON TFT
    Shuqi Chen; Fiscal Year: 2000
    The tubule flow chamber technology (TFT) platform, for use with the blood sampling module, will be developed to create a fully automated sample preparation and testing system for platelet function testing...
  27. MOLECULAR MECHANISMS OF THE IGE ALLERGIC RESPONSE
    Raif Geha; Fiscal Year: 2007
    ..In project #1, based on her previous findings that the transcription factor T-bet dictates the Thl genetic program while the NFAT transcription factors control the production of IL-4, L...
  28. Development of the Closed Tubule PCR Module
    Shuqi Chen; Fiscal Year: 2001
    ..The ct-PCR module incorporates tubule flow-chamber technology (TFT), a micro-fluid mechanical system currently under development for IVD testing, with thermal cycler capabilities ..
  29. Nanoparticle/Metal-Organic Inks for CdZnTe
    DOUGLAS SCHULZ; Fiscal Year: 2002
    ..C) process, the approach is directly amenable to application on amorphous silicon (a-Si) thin film transistor (TFT) arrays...
  30. Transcription Factor T-belt in Dendritic Cells
    Jingsong Wang; Fiscal Year: 2005
    Differentiation from nave T helper (Th) cells into Th1 and Th2 subsets is an important process that determines the immune response to intracellular and or extracellular pathogens via the secretion of distinct cytokines...
  31. REGULATORY TRANSCRIPTS
    SCOTT BLUME; Fiscal Year: 2001
    ..2. To clone and characterize heterologous genes encoding naturally occurring triplex-forming transcripts (tft's) targeted to the human dhfr, cyclin D1, or E2F-1 promoters; and to determine the role of these tft's in ..
  32. FLAT PANEL DETECTOR BASED CONE BEAM VOLUME CT
    Ruola Ning; Fiscal Year: 2002
    ..simulation, phantom and animal studies performed on a prototype imaging system that uses a thin film transistor (TFT) flat panel detector and cone beam tomographic acquisition geometry...
  33. FLAT PANEL DETECTOR BASED CONE BEAM VOLUME CT
    Ruola Ning; Fiscal Year: 2003
    ..simulation, phantom and animal studies performed on a prototype imaging system that uses a thin film transistor (TFT) flat panel detector and cone beam tomographic acquisition geometry...
  34. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2008
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  35. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2006
    ..abstract_text> ..
  36. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2006
    ....
  37. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark Boothby; Fiscal Year: 2004
    ..In particular, the regulated differentiation of type 1 (IFN-gamma) and type 2 (IL-4, IL-5) cytokine production by T cells is controlled by IL-4 and can determine susceptibility to allergic, infectious and autoimmune diseases...
  38. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 2001
    ....
  39. COGNITIVE BEHAVIOR THERAPY OF ADOLESCENT SOCIAL PHOBIA
    James Herbert; Fiscal Year: 2001
    ..It is predicted that both group-CBT and individual-CBT will be more effective than E/SP, and that treatment gains will be maintained through the follow-up period. ..
  40. Integration of Stat6, Co-regulation, and Gene Expression
    Mark Boothby; Fiscal Year: 2007
    ..Taken together, the experiments of these Specific Aims will provide new insights into the regulation of lymphocyte function in immune responses. ..
  41. ALLERGIC AIRWAY RESPONSES--IMMUNE DEVIATION AND MEMORY
    Mark Boothby; Fiscal Year: 2002
    ..To investigate the regulation of antigen-specific T cells responses and disease susceptibility, we have created two new transgenic mouse models...
  42. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2007
    ..This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. [unreadable] [unreadable]..
  43. MOLECULAR PATHOGENESIS OF FELINE SPINAL MUSCULAR ATROPHY
    JOHN FYFE; Fiscal Year: 2002
    ..Initial candidate genes will be those implicated in human SMA, but otherwise a comparative positional-candidate gene approach will be taken. ..
  44. Characterization of Tear Dynamics
    Jianhua Wang; Fiscal Year: 2007
    ..g. dry eye). [unreadable] [unreadable]..
  45. Docosanol and Acyclovir for Treating Genital Herpes
    LAURA POPE; Fiscal Year: 2003
    ..If proven safe and effective, it would provide a new single agent treatment as well as allow concurrent use with acyclovir. PROPOSED COMMERCIAL APPLICATION: Topical treatment for recurrent genital herpes infections. ..
  46. Interferon regulation of T-bet in airway smooth muscle
    CHERIE SINGER; Fiscal Year: 2008
    ..I continue my interest in airway smooth muscle biology with this proposal by examining the T-box transcription factor T-bet in ASM...
  47. Molecular Mechanism of Polarized Cubilin Expression
    JOHN FYFE; Fiscal Year: 2004
    ..Results of these efforts are expected to open a window onto a new aspect of nutrient absorption and membrane receptor biology. ..
  48. Cognitive Psychology of Traumatic Memory
    Richard McNally; Fiscal Year: 2004
    ..g., fantasy proneness, imagery ability) that predict performance in these memory tasks is proposed. ..
  49. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..pylori. CD4 (helper) T cells are necessary and sufficient to induce disease in H...
  50. ANALYSIS OF BIDIRECTIONAL SIGNALING MECHANISMS FOR BTLA AND HVEM IN AUTOIMMUNITY
    Kenneth M Murphy; Fiscal Year: 2010
    We cloned the novel inhibitory receptor B and T Lymphocyte Attenuator (BTLA) in a previous cycle of this Program Project grant, and established that it is an important general regulator of immune responses...
  51. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    AVERIL I MA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The homeostatic maintenance of memory T cells constitutes the cellular basis of immunological memory...
  52. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
    ..The differentiation of effector T cell function is especially important, along with the pro-survival and mitogenic effects of IL-4, can determine ..
  53. THE FUNCTION OF T-BET IN T HELPER CELL DEVELOPMENT
    Stanford Peng; Fiscal Year: 2003
    During ongoing immune responses, naive helper T precursor (Thp) cells differentiate into one of two lineages, Th1 or Th2, characterized by the expression of particular cytokines...
  54. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..Gastritis due to H. pylori is a T helper-1-mediated immune response associated with high levels of IFNgamma and low levels of IL-10 and other anti-..
  55. Transcriptional Regulation of the Type 1 T Cell Response
    Mark Boothby; Fiscal Year: 2005
    The regulation of helper T cell clonal expansion, and differentiation influences the outcome of infections and the susceptibility to autoimmune diseases...
  56. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2005
    DESCRIPTION: The murine model of Leishmania major infection is an exceptional model for investigations of helper T cells subset differentiation in vivo...