SYNGR1

Summary

Gene Symbol: SYNGR1
Description: synaptogyrin 1
Alias: synaptogyrin-1
Species: human

Top Publications

  1. ncbi Characterization of the human synaptogyrin gene family
    D Kedra
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Hum Genet 103:131-41. 1998
  2. ncbi Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I
    R Janz
    Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas 75235, USA
    Neuron 24:687-700. 1999
  3. ncbi A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia
    Ranjana Verma
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi University Campus, Delhi, India
    Biol Psychiatry 55:196-9. 2004
  4. ncbi Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia
    Min Chih Cheng
    Institute of Medical Sciences, Tzu Chi University, Hualien City 970, Taiwan
    J Psychiatr Res 41:1027-31. 2007
  5. doi Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia
    Paraskevas Iatropoulos
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
    Psychiatr Genet 19:237-43. 2009
  6. ncbi SYNGR1 is associated with schizophrenia and bipolar disorder in southern India
    Ranjana Verma
    Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi University Campus, Mall Road, Delhi, 110007, India
    J Hum Genet 50:635-40. 2005
  7. pmc Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
    Hui Guo
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK, Centre for Biostatistics, Institute of Population Health, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK and
    Hum Mol Genet 24:3305-13. 2015
  8. doi Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner
    Pavan Kumar Kakumani
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Biochem J 471:89-99. 2015
  9. pmc High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
    Celi Sun
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Genet 48:323-30. 2016
  10. pmc Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
    Marco Cavalli
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Hum Genet 135:485-97. 2016

Scientific Experts

  • J Mares
  • Christian Löw
  • K Mirnics
  • Tadafumi Kato
  • Ranjana Verma
  • Celi Sun
  • Marco Cavalli
  • Hui Guo
  • Pavan Kumar Kakumani
  • Yabing Wang
  • Paraskevas Iatropoulos
  • Seung Ha Oh
  • Min Chih Cheng
  • Sanjeev Jain
  • Samir K Brahmachari
  • Ingegerd Elvers
  • Loren L Looger
  • Adam Adler
  • Swapan K Nath
  • Kazuhiko Yamamoto
  • Claes Wadelius
  • Kenneth M Kaufman
  • Shin Seok Lee
  • Helena Nord
  • Nan Shen
  • Maija Leena Eloranta
  • Mikhail Dozmorov
  • Hye Soon Lee
  • Seung Cheol Shim
  • Jung Yoon Choe
  • So Young Bang
  • Olof Berggren
  • Xana Kim-Howard
  • Michiaki Kubo
  • Takayuki Sumida
  • Bok Ghee Han
  • Prasenjeet Motghare
  • Yuan yuan Qi
  • Tae Hwan Kim
  • Gang Pan
  • Julio E Molineros
  • Kwangwoo Kim
  • Kerstin Lindblad Toh
  • Xu Jie Zhou
  • Akari Suzuki
  • John B Harley
  • Ola Wallerman
  • Won Tae Chung
  • Young Jin Kim
  • Yukinori Okada
  • Hong Zhang
  • Krishna Bhattarai
  • Sang Cheol Bae
  • Young Mo Kang
  • Yuta Kochi
  • Jianyang Ma
  • Yong Beom Park
  • Jonathan D Wren
  • Lars Rönnblom
  • Emelie Wallén Arzt
  • Kek Heng Chua
  • Chang Hee Suh
  • Oliver S Burren
  • K S Rajgokul
  • Raj K Bhatnagar
  • John A Todd
  • Chris Wallace
  • Arun Prasad Chopra
  • Sunil K Mukherjee
  • Pawan Malhotra
  • Mary D Fortune
  • Srikrishna Mahanty
  • Sanket Singh Ponia
  • Guruprasad R Medigeshi
  • Ellen Schofield
  • Akhil C Banerjea
  • Inderjeet Kaur
  • Guoyin Feng
  • Jie Xu
  • Chiara Magri
  • Teng Zhao
  • Giuseppe Rossi
  • Yun Liu
  • Massimo Gennarelli
  • Lin He
  • Sergio Barlati
  • Chiara Ratti
  • Zhe Liu
  • Damiano Podavini
  • Emilio Sacchetti

Detail Information

Publications16

  1. ncbi Characterization of the human synaptogyrin gene family
    D Kedra
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Hum Genet 103:131-41. 1998
    ..Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1)...
  2. ncbi Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I
    R Janz
    Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas 75235, USA
    Neuron 24:687-700. 1999
    ..Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself...
  3. ncbi A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia
    Ranjana Verma
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi University Campus, Delhi, India
    Biol Psychiatry 55:196-9. 2004
    ..Because Synaptogyrin 1 (SYNGR1), associated with presynaptic vesicles in neuronal cells, lies within 1 million base pairs of this ..
  4. ncbi Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia
    Min Chih Cheng
    Institute of Medical Sciences, Tzu Chi University, Hualien City 970, Taiwan
    J Psychiatr Res 41:1027-31. 2007
    b>Synaptogyrin 1 gene (SYNGR1) is considered as a positional candidate gene for schizophrenia because of its location at chromosome 22q13, a region linked to schizophrenia, and its reduced expression in postmortem brain of patients with ..
  5. doi Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia
    Paraskevas Iatropoulos
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
    Psychiatr Genet 19:237-43. 2009
    b>Synaptogyrin 1 (SYNGR1) is a transmembrane protein of neurotransmitter-containing vesicle. Recently, suggestive association between SYNGR1 intragenic polymorphisms and schizophrenia has been reported in the Indian population...
  6. ncbi SYNGR1 is associated with schizophrenia and bipolar disorder in southern India
    Ranjana Verma
    Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi University Campus, Mall Road, Delhi, 110007, India
    J Hum Genet 50:635-40. 2005
    ..The SYNGR1 gene, which is associated with presynaptic vesicles in neuronal cells, is located on 22q13.1...
  7. pmc Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
    Hui Guo
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK, Centre for Biostatistics, Institute of Population Health, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK and
    Hum Mol Genet 24:3305-13. 2015
    ..cis eQTLs in at least one cell type and at least one disease for six genes: ADAM15, RGS1, CARD9, LTBR, CTSH and SYNGR1. We identified cell-specific effects, such as for CTSH, the expression of which in monocytes, but not in B cells, ..
  8. doi Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner
    Pavan Kumar Kakumani
    International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Biochem J 471:89-99. 2015
    ..along with mRNA profiling of samples overexpressing dvNS3 revealed up-regulation of TAZ (tafazzin) and SYNGR1 (synaptogyrin 1), known dengue viral host factors (DVHFs)...
  9. pmc High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
    Celi Sun
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Genet 48:323-30. 2016
    ..75 × 10(-117), odds ratio (OR) = 2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6...
  10. pmc Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
    Marco Cavalli
    Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Hum Genet 135:485-97. 2016
    ..Functionally validated SNPs support identification of an SNP in SYNGR1 which may expose to the risk of rheumatoid arthritis and primary biliary cirrhosis, as well as an SNP in the last ..
  11. pmc Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1
    Christian Löw
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e38244. 2012
    ..The protein stability is significantly improved in the presence of cholesteryl hemisuccinate as judged by differential light scattering. The approach described here can easily be adapted to other eukaryotic IMPs...
  12. ncbi Prediction of recurrence in low and intermediate risk non-muscle invasive bladder cancer by real-time quantitative PCR analysis: cDNA microarray results
    J Mares
    Charles University, Prague, Czech Republic
    Neoplasma 60:295-301. 2013
    ..the highest differences were detected by ANXA1, ARHGEF4, FLJ32252, GNE, NINJ1, PRICKLE1, PSAT1, RNASE1, SPTAN1, SYNGR1, TNFSF15, TSPAN1, and WDR34...
  13. ncbi Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Neuron 28:53-67. 2000
    ..The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model...
  14. ncbi Molecular genetics of bipolar disorder and depression
    Tadafumi Kato
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Clin Neurosci 61:3-19. 2007
    ..may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6. Of these, association with G72 may be most robust...
  15. ncbi Gene expression and plasticity in the rat auditory cortex after bilateral cochlear ablation
    Seung Ha Oh
    Department of Otolaryngology Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, Korea
    Acta Otolaryngol 127:341-50. 2007
    ..In addition, cross-modal plasticity may play an important role in the early changes in the auditory cortex after bilateral cochlear ablation...
  16. doi No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population
    Yabing Wang
    Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, PR China Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Psychiatry Res 169:167-8. 2009
    Polymorphisms of the SYNAPTOGYRIN1 (SYNGR1) and SYNASINII (SYNII) genes have been shown to be a risk factor for bipolar disorder or schizophrenia...