Genomes and Genes
Gene Symbol: SYNGR1
Description: synaptogyrin 1
- Characterization of the human synaptogyrin gene familyD Kedra
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
Hum Genet 103:131-41. 1998..Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1)...
- Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin IR Janz
Howard Hughes Medical Institute, The University of Texas Southwestern Medical School, Dallas 75235, USA
Neuron 24:687-700. 1999..Our data show that synaptogyrin I and synaptophysin I perform redundant and essential functions in synaptic plasticity without being required for neurotransmitter release itself...
- A nonsense mutation in the synaptogyrin 1 gene in a family with schizophreniaRanjana Verma
Functional Genomics Unit, Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi University Campus, Delhi, India
Biol Psychiatry 55:196-9. 2004..Because Synaptogyrin 1 (SYNGR1), associated with presynaptic vesicles in neuronal cells, lies within 1 million base pairs of this ..
- Identification of rare mutations of synaptogyrin 1 gene in patients with schizophreniaMin Chih Cheng
Institute of Medical Sciences, Tzu Chi University, Hualien City 970, Taiwan
J Psychiatr Res 41:1027-31. 2007b>Synaptogyrin 1 gene (SYNGR1) is considered as a positional candidate gene for schizophrenia because of its location at chromosome 22q13, a region linked to schizophrenia, and its reduced expression in postmortem brain of patients with ..
- Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophreniaParaskevas Iatropoulos
Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
Psychiatr Genet 19:237-43. 2009b>Synaptogyrin 1 (SYNGR1) is a transmembrane protein of neurotransmitter-containing vesicle. Recently, suggestive association between SYNGR1 intragenic polymorphisms and schizophrenia has been reported in the Indian population...
- SYNGR1 is associated with schizophrenia and bipolar disorder in southern IndiaRanjana Verma
Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi University Campus, Mall Road, Delhi, 110007, India
J Hum Genet 50:635-40. 2005..The SYNGR1 gene, which is associated with presynaptic vesicles in neuronal cells, is located on 22q13.1...
- Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseasesHui Guo
JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK, Centre for Biostatistics, Institute of Population Health, The University of Manchester, Jean McFarlane Building, Oxford Road, Manchester M13 9PL, UK and
Hum Mol Genet 24:3305-13. 2015..cis eQTLs in at least one cell type and at least one disease for six genes: ADAM15, RGS1, CARD9, LTBR, CTSH and SYNGR1. We identified cell-specific effects, such as for CTSH, the expression of which in monocytes, but not in B cells, ..
- Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partnerPavan Kumar Kakumani
International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
Biochem J 471:89-99. 2015..along with mRNA profiling of samples overexpressing dvNS3 revealed up-regulation of TAZ (tafazzin) and SYNGR1 (synaptogyrin 1), known dengue viral host factors (DVHFs)...
- High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestryCeli Sun
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Nat Genet 48:323-30. 2016..75 × 10(-117), odds ratio (OR) = 2.38), followed by DEF6, IL12B, TCF7, TERT, CD226, PCNXL3, RASGRP1, SYNGR1 and SIGLEC6...
- Allele-specific transcription factor binding to common and rare variants associated with disease and gene expressionMarco Cavalli
Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Hum Genet 135:485-97. 2016..Functionally validated SNPs support identification of an SNP in SYNGR1 which may expose to the risk of rheumatoid arthritis and primary biliary cirrhosis, as well as an SNP in the last ..
- Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1Christian Löw
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 7:e38244. 2012..The protein stability is significantly improved in the presence of cholesteryl hemisuccinate as judged by differential light scattering. The approach described here can easily be adapted to other eukaryotic IMPs...
- Prediction of recurrence in low and intermediate risk non-muscle invasive bladder cancer by real-time quantitative PCR analysis: cDNA microarray resultsJ Mares
Charles University, Prague, Czech Republic
Neoplasma 60:295-301. 2013..the highest differences were detected by ANXA1, ARHGEF4, FLJ32252, GNE, NINJ1, PRICKLE1, PSAT1, RNASE1, SPTAN1, SYNGR1, TNFSF15, TSPAN1, and WDR34...
- Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortexK Mirnics
Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
Neuron 28:53-67. 2000..The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model...
- Molecular genetics of bipolar disorder and depressionTadafumi Kato
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
Psychiatry Clin Neurosci 61:3-19. 2007..may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6. Of these, association with G72 may be most robust...
- Gene expression and plasticity in the rat auditory cortex after bilateral cochlear ablationSeung Ha Oh
Department of Otolaryngology Head and Neck Surgery, College of Medicine, Seoul National University, Seoul, Korea
Acta Otolaryngol 127:341-50. 2007..In addition, cross-modal plasticity may play an important role in the early changes in the auditory cortex after bilateral cochlear ablation...
- No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese populationYabing Wang
Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, PR China Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
Psychiatry Res 169:167-8. 2009Polymorphisms of the SYNAPTOGYRIN1 (SYNGR1) and SYNASINII (SYNII) genes have been shown to be a risk factor for bipolar disorder or schizophrenia...