synemin

Summary

Gene Symbol: synemin
Description: synemin
Alias: DMN, SYN, synemin, desmuslin, synemin alpha, synemin beta, synemin, intermediate filament protein
Species: human

Top Publications

  1. pmc Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin
    Y Mizuno
    Howard Hughes Medical Institute Division of Genetics, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:6156-61. 2001
  2. ncbi Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells
    Runfeng Jing
    Department of Cellular Biology and Anatomy and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Glia 50:107-20. 2005
  3. ncbi Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 275:17583-9. 2000
  4. ncbi Synemin expression in developing normal and pathological human retina and lens
    Marcel Tawk
    Biologie Moleculaire de la Differenciation, Universite Paris 7, Case Postale 7136, 2 place Jussieu, 75005, Paris, France
    Exp Neurol 183:499-507. 2003
  5. doi Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration
    Ning Sun
    Muscle Biology Group, Department of Biochemistry, Biophysics and Molecular Biology and of Animal Science, Iowa State University, Ames, 3110 Molecular Biology Bldg, IA 50011 3260, USA
    Exp Cell Res 316:491-505. 2010
  6. doi Intermediate filament dynamics and breast cancer: aberrant promoter methylation of the Synemin gene is associated with early tumor relapse
    E Noetzel
    Molecular Oncology Group, Institute of Pathology, Medical Faculty of the RWTH Aachen University, Aachen, Germany
    Oncogene 29:4814-25. 2010
  7. ncbi Enzymic pattern of preneoplastic and neoplastic lesions induced in the kidney of CBA mice by 1,2-dimethylhydrazine
    Y S Ahn
    , Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 22:415-22. 1994
  8. ncbi Regional (14C) 2-deoxyglucose uptake during forelimb movements evoked by rat motor cortex stimulation: cortex, diencephalon, midbrain
    F R Sharp
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    J Comp Neurol 224:259-85. 1984
  9. ncbi Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats
    H K Jin
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 4:449-55. 1991
  10. ncbi On-line identification of diastereomeric dibenzo[a,l]pyrene diol epoxide-derived deoxyadenosine adducts by capillary electrophoresis-fluorescence line-narrowing and non-line narrowing spectroscopy
    K P Roberts
    Ames Laboratory-US Department of Energy, Iowa Sate University 50011, USA
    J Chromatogr A 853:159-70. 1999

Research Grants

  1. Single-molecule study of alpha-synuclein structure modulation by interactions
    CRYSTAL ROSE MORAN-GUTIERREZ; Fiscal Year: 2013
  2. Alan M Lambowitz; Fiscal Year: 2016
  3. MECHANISMS FOR TNF ALPHA IN XENOBIOTIC LIVER INJURY
    Mark Rutherford; Fiscal Year: 2000
  4. JASON T GRAVANO; Fiscal Year: 2014
  5. Judith M Ford; Fiscal Year: 2014
  6. Default mode connectivity in typical development &the schizophrenia prodrome
    SUSANNA FRYER; Fiscal Year: 2013
  7. Default Mode Interference and Working Memory in Mild Traumatic Brain Injury
    Chandler Sours; Fiscal Year: 2013
  8. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
  9. Role of complement in alpha-synuclein based models of Parkinson disease
    HEATHER ELIZABETH ALLEN; Fiscal Year: 2013
  10. Howard E Gendelman; Fiscal Year: 2016

Detail Information

Publications283 found, 100 shown here

  1. pmc Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin
    Y Mizuno
    Howard Hughes Medical Institute Division of Genetics, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:6156-61. 2001
    ..Three overlapping clones were identified that encoded an intermediate filament protein we subsequently named desmuslin (DMN)...
  2. ncbi Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells
    Runfeng Jing
    Department of Cellular Biology and Anatomy and Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Glia 50:107-20. 2005
    b>Synemin, a very unique type VI intermediate filament (IF) protein, exhibits alternative splice variants termed alpha and beta...
  3. ncbi Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites
    V I Slepnev
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 275:17583-9. 2000
    ....
  4. ncbi Synemin expression in developing normal and pathological human retina and lens
    Marcel Tawk
    Biologie Moleculaire de la Differenciation, Universite Paris 7, Case Postale 7136, 2 place Jussieu, 75005, Paris, France
    Exp Neurol 183:499-507. 2003
    b>Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins...
  5. doi Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration
    Ning Sun
    Muscle Biology Group, Department of Biochemistry, Biophysics and Molecular Biology and of Animal Science, Iowa State University, Ames, 3110 Molecular Biology Bldg, IA 50011 3260, USA
    Exp Cell Res 316:491-505. 2010
    b>Synemin is a unique cytoplasmic intermediate filament protein for which there is limited understanding of its exact cellular functions...
  6. doi Intermediate filament dynamics and breast cancer: aberrant promoter methylation of the Synemin gene is associated with early tumor relapse
    E Noetzel
    Molecular Oncology Group, Institute of Pathology, Medical Faculty of the RWTH Aachen University, Aachen, Germany
    Oncogene 29:4814-25. 2010
    b>Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility...
  7. ncbi Enzymic pattern of preneoplastic and neoplastic lesions induced in the kidney of CBA mice by 1,2-dimethylhydrazine
    Y S Ahn
    , Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 22:415-22. 1994
    ..analyzed for the following parameters: glycogen content, basophilia, and the activities of glycogen synthase (SYN), glycogen phosphorylase (PHO), glucose-6-phosphatase (G6Pase), glucose-6-phosphate dehydrogenase (G6PDH), ..
  8. ncbi Regional (14C) 2-deoxyglucose uptake during forelimb movements evoked by rat motor cortex stimulation: cortex, diencephalon, midbrain
    F R Sharp
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    J Comp Neurol 224:259-85. 1984
    ..red nucleus (RNm), posterior deep layers of the superior colliculus (SCsgp), lateral deep mesencephalic nucleus (DMN), nucleus tegmenti pedunculopontinus (NTPP), and anterior pretectal nucleus (NCU)...
  9. ncbi Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats
    H K Jin
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 4:449-55. 1991
    ..hypothalamic nucleus (PVN), ventromedial hypothalamic nucleus (VMN), dorsomedial hypothalamic nucleus (DMN), lateral hypothalamic nucleus (LN), and posterior hypothalamic area (PHA), were compared in 10-week-old male SHR-S ..
  10. ncbi On-line identification of diastereomeric dibenzo[a,l]pyrene diol epoxide-derived deoxyadenosine adducts by capillary electrophoresis-fluorescence line-narrowing and non-line narrowing spectroscopy
    K P Roberts
    Ames Laboratory-US Department of Energy, Iowa Sate University 50011, USA
    J Chromatogr A 853:159-70. 1999
    ..In addition, it was determined that in CE buffer trans-syn-,cis-syn- and cis-anti-DB[a,l]PDE-14-N6dA diastereomeric adducts exist mostly with the -dA and DB[a,l]P moiety in ..
  11. pmc Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis
    H L Weng
    Institute of Infectious Diseases, First Affiliated Hospital, Medical School, Zhejiang University, 261 Qingchun Lu, Hangzhou 310003, Zhejiang Province, China
    World J Gastroenterol 7:42-8. 2001
    ..To evaluate the antifibrotic effect of different doses of recombinant human Gamma-Interferon (IFN-gamma) in two rat models of hepatic fibrosis, and to observe its effect on moderate chronic hepatitis B virus fibrosis...
  12. ncbi Inhibition of the bovine-heart mitochondrial F1-ATPase by cationic dyes and amphipathic peptides
    D A Bullough
    Department of Chemistry, University of California, San Diego, La Jolla 92093
    Biochim Biophys Acta 975:377-83. 1989
    ..7, 649-653) to function in mitochondrial import when attached to dihydrofolate reductase (delta 11.12, Syn-A2, and Syn-C). The order of effectiveness of the peptide inhibitors as assessed by I0...
  13. doi Effects of natural (RRR alpha-tocopherol acetate) or synthetic (all-rac alpha-tocopherol acetate) vitamin E supplementation on reproductive efficiency in beef cows
    M Horn
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Anim Sci 88:3121-7. 2010
    ..containing no additional vitamin E (CON), 2) formulated to provide 1,000 IU x d(-1) of synthetic-source vitamin E (SYN; all-rac or dl-alpha-tocopherol acetate), or 3) formulated to provide 1,000 IU x d(-1) of natural-source vitamin E (..
  14. pmc Refinement of the solution structure of a branched DNA three-way junction
    I V Ouporov
    Chemistry Department, Bowling Green State University, Ohio 43403 0213
    Biophys J 68:266-74. 1995
    ..Analysis of the refined structure reveals that the glycosidic bond of S3-T6 exists in the syn conformation, allowing the methyl group of this residue to contact the hydrophobic surface of the minor groove of ..
  15. ncbi Relationship between joint motion and flexor tendon force in the canine forelimb
    R L Lieber
    Department of Orthopaedics, University of California, San Diego, USA
    J Hand Surg Am 21:957-62. 1996
    ..extension and finger flexion were performed simultaneously, followed by wrist flexion and finger extension (group SYN). In addition, tendon force was measured during electric stimulation of the proximal flexor muscle mass...
  16. ncbi The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme
    Joe Tiralongo
    Institute for Glycomics, Griffith University Gold Coast Campus, PMB 50 Gold Coast Mail Centre 9726, Gold Coast, QLD, Australia
    Glycobiology 17:945-54. 2007
    ..is the activation of Sia to cytidine monophosphate-Sia (CMP-Sia), by CMP-Sia synthetases (CMP-Sia-syn)...
  17. ncbi Unique organoprotective properties of a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and mocap-induced neurotoxicity in mice
    S D Ray
    Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
    Res Commun Mol Pathol Pharmacol 107:105-28. 2000
    ..ii) quantify GSPE's capacity to avert cadmium chloride (CdCl2)-induced nephrotoxicity, dimethylnitrosamine (DMN)-induced splenotoxicity and O-ethyl-S,S-dipropyl phosphorodithioate (MOCAP)-induced neurotoxicity, and lastly (iii) ..
  18. ncbi Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis
    Yi Chao Hsu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Gastroenterol Hepatol 22:99-111. 2007
    ..The purpose of the present study was to investigate the in vitro and in vivo effects of Tet on hepatic fibrosis...
  19. ncbi Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan
    Metabolism 54:445-52. 2005
    ..Liver cirrhosis was induced in male Sprague-Dawley rats by dimethylnitrosamine (DMN) administration or by common bile duct ligation (BDL). Ad libitum and pair-fed animals constituted controls...
  20. ncbi Enhanced macrophage anti-microbial activity following dimethylnitrosamine exposure in vivo is related to augmented production of reactive oxygen metabolites
    C K Edwards
    Department of Animal Sciences, University of Illinois, Urbana 61801
    Immunopharmacol Immunotoxicol 13:395-411. 1991
    Previous results demonstrated that mice exposed in vivo to DMN were more resistant to both bacterial and tumor challenges. Furthermore, macrophages (M phi) isolated from these animals demonstrated increased functional properties...
  21. pmc Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway
    Larissa C Wilsie
    Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, MSC08 4670 1 University of New Mexico, Albuquerque, New Mexico, 87131, USA
    Lipids Health Dis 5:23. 2006
    ..We investigated if syndecan-1 (Syn-1), a transmembrane cell surface HSPG, is able to mediate the internalization of apoE-VLDL and examined the ..
  22. doi A polyphasic approach to the taxonomy of the Alternaria infectoria species-group
    Birgitte Andersen
    Center for Microbial Biotechnology CMB, Department of Systems Biology, Building 221, Technical University of Denmark, Kgs Lyngby, Denmark
    Fungal Genet Biol 46:642-56. 2009
    ..infectoria species-group together with 12 strains belonging to closely related species: Alternaria malorum (syn. Cladosporium malorum), Chalastospora cetera (syn. Alternaria cetera) and Embellisia abundans...
  23. doi Synthesis and characterization of anti-bisFe(III) porphyrins, syn-bisFe(III)-mu-oxo porphyrin, and syn-bisFe(III)-mu-oxo porphyrin cation radical
    Sudip Kumar Ghosh
    Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India
    Inorg Chem 49:3449-60. 2010
    ..linker are reported in which the bisporphyrin platform "opens" and "closes" its binding pockets leading to facile syn-anti conformational switching with very high vertical flexibility in a single molecular framework...
  24. ncbi Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
    B A Diwan
    Biological Carcinogenesis and Development Program, Program Resources, Inc, Frederick Cancer Research Facility, MD
    Carcinogenesis 10:183-8. 1989
    ..tract and other organs were investigated in rats following initiation with methyl(acetoxymethyl)nitrosamine (DMN-OAc). Four-week-old F344/NCr male rats were given a single i.p. injection of 0.05 nmol DMN...
  25. ncbi Morphological and functional characterization of a rat vaginal smooth muscle sphincter
    A Giraldi
    Division of Sexual Physiology, Department of Medical Physiology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Impot Res 14:271-82. 2002
    ..5 (PGP), synaptophysin (Syn), tyrosine hydroxylase (TH), vesicular acetylcholine transporter (VAChT), neuropeptide Y (NPY), nitric oxide ..
  26. ncbi Fluorescence and photochemistry of recombinant phytochrome from the cyanobacterium Synechocystis
    V Sineshchekov
    Biology Department, M V Lomonosov Moscow State University, Russia
    Photochem Photobiol 67:263-7. 1998
    ..in Escherichia coli and assembled to a holophytochrome with phycocyanobilin (PCB) and phytochromobilin (P phi B), Syn(PCB)phy and Syn(P phi B)phy, respectively...
  27. ncbi Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila
    M J Nivard
    MGC Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, Sylvius Laboratories, Netherlands
    Mutat Res 352:97-115. 1996
    ..compounds: N-methyl-N-nitrosourea (MNU); N-methyl-N'-nitro-N-nitrosoguanidine (MNNG); and N-nitrosodimethylamine (DMN). With MNU and DMN, the impact of DNA nucleotide excision repair (NER) on the spectra of mutations was studied...
  28. pmc Interspecies comparison of pharmacokinetics of the novel triazole antifungal agent SYN-2869 and its derivatives
    J K Khan
    Division of Biopharmaceutics and Pharmacokinetics, NAEJA Pharmaceutical Inc, Edmonton, Alberta T6E 5V2, Canada
    Antimicrob Agents Chemother 44:910-5. 2000
    ..The purpose of the study was also to determine species differences in pharmacokinetics for SYN azoles to select the most appropriate species for secondary efficacy and toxicological evaluation of the selected ..
  29. pmc MO tripeptide diastereomers (M=99/99mTc, Re): models to identify the structure of 99mTc peptide targeted radiopharmaceuticals
    Melchor V Cantorias
    Department of Chemistry, Hunter College and the Graduate Center of the City University of New York, 695 Park Avenue, New York, New York 10021, USA
    Inorg Chem 46:7326-40. 2007
    ..Upon complexation with [TcO]3+, two products form; these are syn and anti diastereomers, and they often have different biological behavior...
  30. ncbi Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a deconvolution microscopic study
    W Barry VanWinkle
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Anat Rec 268:38-46. 2002
    Syndecan-4 (syn-4), a transmembrane heparan sulfate-containing proteoglycan, is unique among the four members of the syndecan family in its specific cellular localization to complex cytoskeletal adhesion sites, i.e., focal adhesions...
  31. pmc Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products
    Lan Chen
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9052. 2010
    Alpha synuclein (alpha-Syn) is the main component of Lewy bodies which are associated with several neurodegenerative diseases such as Parkinson's disease...
  32. doi Synthesis, structure and electrochemistry of isomeric nickel(II) complexes of a [9]ane fused cyclam macrotricycle: evidence for a stable trans-IV and a redox induced rearrangement in a trans-I conformation
    Alex McAuley
    Department of Chemistry, University of Victoria, P O Box 3065, Victoria, V8W 3P6, BC, Canada
    Dalton Trans 39:9956-61. 2010
    ..In the cis-[Ni(trans-I, syn-L3)](Cl(2))·4H(2)O, the syn-isomer of L3 is present in which the cyclam ring adopts a trans-I stereochemistry...
  33. pmc Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology
    Karen A Lewis
    Graduate Program in Molecular Biophysics, Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Am J Pathol 177:3037-50. 2010
    ..hallmark of Parkinson's disease and diffuse Lewy body disease (DLBD) is the aggregation of α-synuclein (α-syn) in the form of Lewy bodies and Lewy neurites...
  34. ncbi Physiology of lateral line mechanoreceptive regions in the elasmobranch brain
    H Bleckmann
    Neurobiology Unit, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093
    J Comp Physiol A 164:459-74. 1989
    ..sphere stimulus, neural responses were recorded in the medullary medial octavolateralis nucleus (MON), the dorsal (DMN) and anterior (AN) nucleus of the mesencephalic nuclear complex, the diencephalic lateral tuberal nucleus (LTN), ..
  35. ncbi Brain imaging agents: synthesis and characterization of (N-piperidinylethyl) hexamethyl diaminodithiolate oxo technetium(V) complexes
    L A Epps
    Johns Hopkins Medical Institutions, Baltimore, MD 21205 2179
    Int J Rad Appl Instrum A 38:661-4. 1987
    ..These results indicate that the two 99Tc (NEP-DADT) complexes are syn and anti isomers (i.e...
  36. ncbi A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea
    S Asakura
    Tsukuba Drug Safety Research, Drug Safety Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Toxicol Lett 98:155-67. 1998
    ..effects were studied in the hepatocytes of F344 rats exposed in vivo to the methylating agents dimethylnitrosamine (DMN, hepatocarcinogen) and methylnitrosourea (MNU, non-hepatocarcinogen)...
  37. ncbi Examination of isomer specific bioaccumulation parameters and potential in vivo hepatic metabolites of syn- and anti-Dechlorane Plus isomers in juvenile rainbow trout (Oncorhynchus mykiss)
    Gregg T Tomy
    Department of Fisheries and Oceans, Arctic Aquatic Research Division, Winnipeg, MB R3T 2N6, Canada
    Environ Sci Technol 42:5562-7. 2008
    Juvenile rainbow trout (Oncorhynchus mykiss) were exposed in the laboratory to elevated doses of syn- and anti-isomers of Dechlorane Plus (DP) via their diet for 49 days (uptake phase), followed by 112 days of untreated food (depuration ..
  38. pmc Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
    Igor F Tsigelny
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 3:e3135. 2008
    ..oligomers has been identified as one of the central toxic events in AD, accumulation of alpha-synuclein (alpha-syn) resulting in the formation of oligomers and protofibrils has been linked to PD and Lewy body Disease (LBD)...
  39. ncbi Distribution of AMPA receptor subunits GluR1-4 in the dorsal vagal complex of the rat: a light and electron microscope immunocytochemical study
    J P Kessler
    Laboratoire de Neurobiologie, UPR 9024, Centre National de la Recherche Scientifique, 31, chem Joseph Aiguier, F13402 Marseille cx 20, France
    Synapse 34:55-67. 1999
    ..the dorsomedial medulla, includes the nucleus tractus solitarii (NTS), the dorsal motor nucleus of the vagus nerve (DMN) and the area postrema (AP)...
  40. ncbi Origin of syn/anti diastereoselectivity in aldehyde and ketone crotylation reactions: a combined theoretical and experimental study
    Lutz F Tietze
    Institut fur Organische und Biomolekulare Chemie, Georg August Universitat Gottingen, Tammannstrasse 2, D 37077 Gottingen, Germany
    J Am Chem Soc 128:11483-95. 2006
    ..We found that corresponding MCC and AS reactions give nearly equal syn/anti ratios...
  41. ncbi Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice
    B E Butterworth
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 31:248-56. 1998
    ..The positive control, dimethylnitrosamine (DMN) is a DNA-reactive mutagen and carcinogen...
  42. ncbi Performance and digestibilities of beef cattle fed diets supplemented with either soybean meal or roasted soybeans and implanted with Synovex
    T S Rumsey
    Growth Biology Laboratory, Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:1631-7. 1999
    ..degrees C for 10 min) or soybean meal (SBM) and implanting or not implanting with an estrogenic growth promoter (SYN; Synovex-S, 20 mg of estradiol benzoate plus 200 mg of progesterone or Synovex-H, 20 mg of estradiol benzoate plus ..
  43. ncbi Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice
    B S Shane
    Institute for Environmental Studies, Louisiana State University, 70803, Baton Rouge, LA 70803, USA
    Mutat Res 452:197-210. 2000
    ..spectrum (MS) of lacI and cII from the same DNA samples isolated from the liver of control and dimethylnitrosamine (DMN)-treated mice. A three-fold (p<0...
  44. ncbi Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment
    David L King
    Memory and Aging Research Laboratory, SCA 110, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Brain Res 926:58-68. 2002
    ..In the present study, synaptophysin immunoreactivity (SYN-IR; a marker for synaptic terminals) was evaluated in the neocortex and hippocampus of behaviorally-tested Tg2576 ..
  45. ncbi Calcitonin immunoreactivity in neoplastic and hyperplastic parathyroid glands: an immunohistochemical study
    Ashraf Khan
    Department of Pathology and Surgery, University of Massachusetts Medical School, Worcester, MA, USA
    Endocr Pathol 14:249-55. 2003
    ..e., synaptophysin (SYN) and CD57 (Leu7), are also present in normal, hyperplastic, and neoplastic parathyroid tissue and to assess their ..
  46. ncbi A comparison of cryopreserved vein allografts and prosthetic grafts for hemodialysis access
    Robert L Madden
    Transplant Division, Department of Surgery, Baystate Medical Center, Springfield, MA 01107, USA
    Ann Vasc Surg 19:686-91. 2005
    ..of PTFE complications, our group and others have used cryopreserved cadaver femoral vein allografts (Synergraft [SYN], CryoLife, Marietta, GA) in selected patients...
  47. ncbi Isomers of dechlorane plus in Lake Winnipeg and Lake Ontario food webs
    Gregg T Tomy
    Department of Fisheries and Oceans, Winnipeg, Manitoba, R3T 2N6 Canada
    Environ Sci Technol 41:2249-54. 2007
    The extent of bioaccumulation of the syn- and anti-isomers of Dechlorane Plus (DP) is assessed in archived food web samples from Lake Winnipeg and Lake Ontario...
  48. doi Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel
    Betty Ng
    Department of Medicine, University of Toronto, Room 7310, Medical Sciences Building, Toronto, ON, Canada
    Cardiovasc Res 80:365-74. 2008
    Syntaxin (Syn)-1A binds sulfonylurea receptor (SUR) nucleotide binding folds of cardiac myocyte (SUR2A) and islet beta-cells (SUR1) to inhibit ATP-sensitive potassium (K(ATP)) channels...
  49. doi The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state
    Michael A Campbell
    School of Science, Penn State Erie, The Behrend College, P 1 Prischak Building, 4205 College Drive, Erie, PA 16563 0203, USA
    Plant Mol Biol 73:181-9. 2010
    Chlorpropham (CIPC) and 1,4-dimethylnapthalene (DMN) are used to control postharvest sprouting of potato tubers. CIPC alters microtubule structure and function resulting in inhibition of cell division...
  50. ncbi Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
    M Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Mol Med 8:553-60. 2001
    ..preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight...
  51. ncbi [Fatty acid composition of serum phospholipids and the effect of insulin in patients with type 2 diabetes]
    T Pelikanova
    Centrum diabetologie Institutu klinické a experimentální medicíny, Praha
    Cas Lek Cesk 141:55-60. 2002
    ..The aim of our study was to confirm the above relation in different groups of type 2 diabetic patients (DM2)...
  52. ncbi Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells
    Isao Sakaida
    Department of Gastroenterology and Hepatology School of Medicine, Yamaguchi University, Yamaguchi Pref 755 8505, Ube, Japan
    Life Sci 72:943-59. 2003
    ..MMP-13, 9) of Kupffer cells induced by gadolinium chloride (GdCl(3)) treatment can reverse dimethylnitrosamine (DMN)-induced liver fibrosis (in vivo) and the effect of GdCl(3) on MAP kinase activity (in vitro)...
  53. ncbi Pravastatin decreases cold ischemia--but not alloantigen-dependent transplant arteriosclerosis
    J Dominguez
    Department of Urology, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Diagonal Paraguay 437 Depto C, Santiago, Chile
    Transplant Proc 35:3121-4. 2003
    ..We studied the effect of PR on cold ischemia and alloantigen-induced transplant arteriosclerosis in syngeneic (SYN) and allogeneic (ALLO) aortic transplantation models.
  54. ncbi Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
    Monika Roller
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition and Food, Haid und Neu Str 9, D 76131 Karlsruhe, Germany
    Br J Nutr 97:676-84. 2007
    Probiotics (PRO) modulate immunity in humans, while the effect of prebiotics (PRE) and synbiotics (SYN) on the human immune system are not well studied yet...
  55. ncbi Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons
    Boris Mravec
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Brain Res Bull 74:147-54. 2007
    The hypothalamic dorsomedial nucleus (DMN) represents an important coordinate center for regulation of autonomic and neuroendocrine systems, especially during stress response...
  56. doi Formation and development of Lewy pathology: a critical update
    Kurt A Jellinger
    Institute of Clinical Neurobiology, Kenyongasse 18, 1070, Vienna, Austria
    J Neurol 256:270-9. 2009
    ..inclusions in neurons (Lewy bodies, LB) and dystrophic neurites containing pathologic alpha-synuclein (alpha Syn) are the morphologic hallmarks of sporadic Parkinson disease (PD) and dementia with Lewy bodies (DLB), but are also ..
  57. pmc Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity
    Diana L Price
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14020. 2010
    ..disorders of the aging population characterized by the abnormal accumulation of alpha-synuclein (alpha-syn)...
  58. ncbi Differentiation of necrotic cell death with or without lysosomal activation: application of acute liver injury models induced by carbon tetrachloride (CCL4) and dimethylnitrosamine (DMN)
    M Yasuda
    Department of Pathology, School of Medicine, Tokai University, Kanagawa, Japan
    J Histochem Cytochem 48:1331-9. 2000
    ..of lysosomal integrity) in necrotic cell death induced by carbon tetrachloride (CCl4) and dimethylnitrosamine (DMN): coagulation necrosis and hemorrhagic necrosis, respectively...
  59. ncbi A new hypothesis of pathogenesis based on the divorce between mitochondria and their host cells: possible relevance for Alzheimer's disease
    L F Agnati
    Department of Biomedical Sciences, University of Modena and IRCCS Lido, Venezia, Italy
    Curr Alzheimer Res 7:307-22. 2010
    ..Furthermore, the present data demonstrate the presence of alpha-synuclein (alpha-syn) within TNTs, hence a similar pathogenic mechanism to the one surmised for AD, but centred on alpha-syn rather than ..
  60. ncbi Antibodies against the amino-terminal portion of pro-enkephalin inhibit DNA synthesis in human peripheral mononuclear cells
    M R Padros
    Instituto de Fisiologia, Universidad Autonoma de Puebla, Mexico
    J Neuroimmunol 61:79-83. 1995
    ..Met-enkephalin (ME) and/or synenkephalin (SYN)-containing peptides are produced and released by human peripheral blood lymphocytes (HPBL) activated with ..
  61. ncbi Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice
    T Suzuki
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 28:348-53. 1996
    Organ specificity in the lacI mutant frequency (MF) induced by dimethylnitrosamine (DMN) was analyzed in lung, liver, kidney, bone marrow, urinary bladder, and testis of Big Blue mice...
  62. ncbi Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Ann N Y Acad Sci 920:33-41. 2000
    The 15-20 kDa synuclein (SYN) phosphoproteins are abundantly expressed in nervous tissue. Members of the family include alpha- and beta-SYN, and the more distantly related gamma-SYN and synoretin...
  63. ncbi A novel mechanism of interaction between alpha-synuclein and biological membranes
    Yoon Suk Kim
    The Parkinson s Institute, Sunnyvale, CA 94089, USA
    J Mol Biol 360:386-97. 2006
    Conformational abnormalities and aggregation of alpha-synuclein (alpha-syn) have been linked to the pathogenesis of Parkinson's (PD) and related diseases...
  64. doi N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    J Biochem Mol Toxicol 22:389-95. 2008
    ..investigated the protective effect of gossypol, selenium, zinc, or glutathione (GSH) against dimethylnitrosamine (DMN)-induced hepatotoxicity in the livers of male mice...
  65. doi Expression and subcellular location of alpha-synuclein during mouse-embryonic development
    Shan Chuan Zhong
    Department of Histology and Embryology, Third Military Medical University, Shapingba District, Chongqing, 400038, China
    Cell Mol Neurobiol 30:469-82. 2010
    Alpha-synuclein (alpha-SYN) is one of the major components of intracellular fibrillary aggregates in the brains of a subset of neurodegenerative disorders...
  66. doi Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology
    Melanie Gerard
    Laboratories of Biochemistry, Interdisciplinary Research Centre, Katholieke Universiteit Leuven Kortrijk, Flanders, Belgium
    J Neurosci 30:2454-63. 2010
    alpha-Synuclein (alpha-SYN) is a key player in the pathogenesis of Parkinson's disease (PD). In pathological conditions, the protein is present in a fibrillar, aggregated form inside cytoplasmic inclusions called Lewy bodies...
  67. pmc Species recognition and clinical relevance of the zygomycetous genus Lichtheimia (syn. Absidia pro parte, Mycocladus)
    Ana Alastruey-Izquierdo
    Instituto de Salud Carlos III Mycology Department, Spanish National Center for Microbiology, Ctra Majadahonda Pozuelo km 2, Majadahonda Madrid 28220, Spain
    J Clin Microbiol 48:2154-70. 2010
    The zygomycete genus Lichtheimia (syn. Absidia pro parte, Mycocladus) consists of saprotrophic fungi inhabiting soil or dead plant material. Lichtheimia corymbifera (syn...
  68. doi Systematics and molecular phylogeny of two African stem borer genera, Sciomesa Tams & Bowden and Carelis Bowden (Lepidoptera: Noctuidae)
    P Moyal
    IRD CNRS Laboratoire Evolution Génomes Spéciation, Avenue de la Terrasse, B P 1, 91198 Gif sur Yvette Cedex, France
    Bull Entomol Res 100:641-59. 2010
    ..Carelis transversa sp. n. and Carelis agnae sp. n. Ten species were sunk as synonyms: Sciomesa mesoscia (Hampson) syn. n., Sciomesa mirifica Laporte syn. n., Sciomesa constantini Laporte syn. n. and Sciomesa etchecopari Laporte syn...
  69. ncbi Endocrine and ovarian responses to prolonged adrenal stimulation at the time of induced corpus luteum regression
    G Gabai
    Dipartimento di Scienze Sperimentali Veterinarie, Universita di Padova, Legnaro PD, Italy
    Reprod Domest Anim 41:485-93. 2006
    ..h, animals received 12 injections of either saline (CTR) or adrenocorticotrophic hormone (ACTH) agonist (Synacthen; SYN) every 12 h...
  70. ncbi Check list and geographical distribution of phlebotomine sandflies in China
    Y J Leng
    Department of Medical Parasitology, Faculty of Medicine, Jinan University, Guangzhou, China
    Ann Trop Med Parasitol 87:83-94. 1993
    ..Five species, namely Phlebotomus alexandri, P. chinensis, P. longiductus, P. sichuanensis and P. smirnovi (syn. P. wui), are known to be vectors of human leishmaniasis...
  71. ncbi Reduction of acyl enolates of alpha-substituted beta-keto esters by bakers' yeast
    H Ohta
    Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yakohama 223, Japan
    Agric Biol Chem 54:489-93. 1990
    ..The syn-selectivities of this reaction increased compared with those of the reduction of the corresponding racemic keto ..
  72. ncbi Translesion synthesis by human DNA polymerase eta across thymine glycol lesions
    Rika Kusumoto
    Institute for Molecular and Cellular Biology, Osaka University, and CREST, Japan Science and Technology Corporation, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochemistry 41:6090-9. 2002
    ..product, human DNA polymerase eta (pol eta), catalyzes efficient and accurate translesion synthesis (TLS) past cis-syn thymine-thymine dimers (TT dimer)...
  73. ncbi Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus
    N Ulfig
    Department of Anatomy, Neuroembryonic Research Laboratory, University of Rostock, Germany
    Neurosignals 11:95-102. 2002
    ..the development of rubral afferents, the expression of A kinase anchoring protein 79 (AKAP79) and synaptophysin (SYN) was examined in the human fetal red nucleus...
  74. ncbi Infection of Psoroptes mites with the fungus Metarhizium anisopliae
    A J Brooks
    School of Biological Sciences, University of Bristol, Woodland Road, BS8 1UG, Bristol, UK
    Exp Appl Acarol 25:869-80. 2001
    ..ovis derived from rabbits (syn. P. cuniculi). The immersion of mites in a suspension of conidia of M...
  75. ncbi Formation of Meta III during the decay of activated rhodopsin proceeds via Meta I and not via Meta II
    Reiner Vogel
    Biophysics Group, Institut für Molekulare Medizin und Zellforschung, Albert Ludwigs Universitat Freiburg, Hermann Herder Strasse 9, D 79104 Freiburg, Germany
    Biochemistry 43:9457-66. 2004
    ..decay specifically by thermal isomerization of the protonated Schiff base C=N double bond to an all-trans 15-syn chromophore isomer, corresponding to that of Meta III...
  76. ncbi Sequential coupling of zincated hydrazone, alkenylboronate, and electrophile that creates several contiguous stereogenic centers
    Masaharu Nakamura
    Department of Chemistry, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 126:14344-5. 2004
    A zincated N,N-dimethylhydrazone of a ketone undergoes stereospecific syn addition to E- or Z-alkenylboronate to generate a gamma-Zn/B dimetallic intermediate, which reacts with a carbon electrophile to give a gamma-borylhydrazone in ..
  77. ncbi Preparation of cyclic peptide libraries using intramolecular oxime formation
    Kade D Roberts
    School of Chemistry, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia
    J Pept Sci 10:659-65. 2004
    ..This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.
  78. ncbi [The investigation of Syn and NPY expression in brain tissues of diabetic model rat induced by streptozotocin]
    Xiao Ming Zhang
    Department of Anatomy, Medical College, Zhejiang University, Hangzhou 310006, China
    Shi Yan Sheng Wu Xue Bao 37:449-55. 2004
    The synaptophysin (Syn) and neuropeptide Y (NPY) expressions in brain tissue of diabetic model rats were investigated. 20 adult Sprague-Dawley male rats were randomly divided into two groups...
  79. ncbi Vibrational spectra and analysis of acetohydrazide CH3-CO-NH-NH2
    Hassan M Badawi
    Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
    Spectrochim Acta A Mol Biomol Spectrosc 67:592-7. 2007
    ..The molecule was predicted to have a trans-syn (N-H bond is trans with respect to CO bond and NH(2) moiety is syn to C-N bond) conformation as the lowest energy ..
  80. ncbi Luminescence and Raman spectra of acetylacetone at low temperatures
    Vlasta Mohacek-Grosev
    Ruder Boskovic Institute, P O Box 180, Bijenicka c 54, 10002 Zagreb, Croatia, and Faculty of Chemical Engineering and Technology, Marulicev trg 19, 10000 Zagreb, Croatia
    J Phys Chem A 111:5820-7. 2007
    ..Their decay results in population of different isomer states, which except for the lowest isomers SYN enol, TS2 enol (described in Matanović I.; Doslić, N. J. Phys. Chem...
  81. pmc Trace amine-associated receptor 1-Family archetype or iconoclast?
    David K Grandy
    Department of Physiology and Pharmacology, L334, School of Medicine, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Ther 116:355-90. 2007
    ..activated by the "trace amines" (TA) beta-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of 2 publications that appeared in 2001 describing the cloning of a ..
  82. pmc Spectroscopic evidence for an all-ferrous [4Fe-4S]0 cluster in the superreduced activator of 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans
    Marcus Hans
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, 35032 Marburg, Germany
    J Biol Inorg Chem 13:563-74. 2008
    ..of glutamate by Acidaminococcus fermentans, 2-hydroxyglutaryl-coenzyme A dehydratase, catalyzes the reversible syn-elimination of water from (R)-2-hydroxyglutaryl-coenzyme A, resulting in (E)-glutaconylcoenzyme A...
  83. pmc Differential release and phagocytosis of tegument glycoconjugates in neurocysticercosis: implications for immune evasion strategies
    Jorge I Alvarez
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    PLoS Negl Trop Dis 2:e218. 2008
    ..little is known about the initial response to this infection, a murine model using the cestode Mesocestoides corti (syn. Mesocestoides vogae) was employed to analyze morphological changes in the parasite early in the infection...
  84. doi Single-molecule FRET reveals structural heterogeneity of SDS-bound alpha-synuclein
    Gertjan Veldhuis
    Biophysical Engineering Group, MESA Institute for Nanotechnology and Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Chembiochem 10:436-9. 2009
    SDS-concentration-dependent alpha-synuclein structure: Upon interaction with SDS, alpha Syn folds into a structure with two antiparallel alpha-helices...
  85. pmc Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux
    Roberta Marongiu
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    J Neurochem 108:1561-74. 2009
    Parkinson's disease (PD) is characterized by accumulation of alpha-synuclein (alpha-syn) and degeneration of neuronal populations in cortical and subcortical regions...
  86. doi Cardiorespiratory effects on default-mode network activity as measured with fMRI
    Mariët van Buuren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 30:3031-42. 2009
    The default-mode network (DMN) consists of areas showing more activation during rest than during a task...
  87. doi Shed syndecan-1 restricts neutrophil elastase from alpha1-antitrypsin in neutrophilic airway inflammation
    Stanley C H Chan
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China
    Am J Respir Cell Mol Biol 41:620-8. 2009
    ..Western blot analysis found NE in a supramolecular complex with shed ectodomains of syndecan (Syn)-1 in sputum sol samples and, as such, inhibition of NE activity was incomplete, even with addition of exogenous ..
  88. pmc Brain encoding of acupuncture sensation--coupling on-line rating with fMRI
    Vitaly Napadow
    MGH HMS MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 47:1055-65. 2009
    ..insula) and cognitive (dorsomedial prefrontal cortex (dmPFC)) processing, and deactivation in default-mode network (DMN) regions (posterior cingulate, precuneus)...
  89. doi Robustness and generalization of structure-based models for protein folding and function
    Heiko Lammert
    Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093, USA
    Proteins 77:881-91. 2009
    ..Individual contact pairs can switch between distinct states to match the competing syn and anti structures. The flexibility of the new potential facilitates advanced uses of structure-based models...
  90. pmc Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence
    Vitaly Kuryavyi
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Structure 18:73-82. 2010
    ..This G-quadruplex, composed of three stacked G-tetrads containing four syn guanines, represents a new folding topology with two unique conformational features...
  91. doi Trinuclear and mononuclear copper(II) complexes incorporating tetradentate 2,2'-[1,1'-(ethylenedioxydinitrilo)diethylidyne]diphenol ligand: Syntheses, crystal structures, spectral and thermal behaviors
    Wen Kui Dong
    School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 76:476-83. 2010
    ..In complex 2, two acetate ions coordinate to three Cu(II) ions adopting a familiar syn-syn (muM-O-C-O-M) coordinated fashion. The central Cu(II) ion sits in a crystallographic inversion centre...
  92. pmc Attention-related networks in Alzheimer's disease: a resting functional MRI study
    Rui Li
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
    Hum Brain Mapp 33:1076-88. 2012
    ..the sensitivity and specificity of these networks as potential biomarkers compared with the default mode network (DMN)...
  93. doi Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells
    Sa Suk Kim
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Korea
    Arch Pharm Res 34:837-45. 2011
    Alpha-synuclein (α-SYN) is a small and highly conserved presynaptic protein that is implicated in both normal brain function and the pathogenesis of neurodegenerative diseases...
  94. doi Diastereoselective construction of syn-1,3-dioxanes via a bismuth-mediated two-component hemiacetal/oxa-conjugate addition reaction
    P Andrew Evans
    Department of Chemistry, The University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom
    J Am Chem Soc 134:2856-9. 2012
    ..of δ-trialkylsilyloxy and δ-hydroxy α,β-unsaturated aldehydes and ketones with alkyl aldehydes provides the syn-1,3-dioxanes in a highly efficient and stereoselective manner...
  95. doi Iterative asymmetric allylic substitutions: syn- and anti-1,2-diols through catalyst control
    Jin Kyoon Park
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, 32306 4390, USA
    Angew Chem Int Ed Engl 51:2717-21. 2012
    A copper-catalyzed asymmetric allylic boronation (AAB) gives access to syn- and anti-1,2-diols...
  96. pmc DLK1 is a somato-dendritic protein expressed in hypothalamic arginine-vasopressin and oxytocin neurons
    Carine Villanueva
    INSERM, U676, Paris, France
    PLoS ONE 7:e36134. 2012
    ..DLK1 expression in the suprachiasmatic (SCN), supraoptic (SON), paraventricular (PVN), arcuate (ARC), dorsomedial (DMN) and lateral hypothalamic (LH) nuclei...
  97. doi Changes in the brain intrinsic organization in both on-task state and post-task resting state
    Zhijiang Wang
    International WIC Institute, Beijing University of Technology, China
    Neuroimage 62:394-407. 2012
    ..connectivity within local spatial patterns during or after task performance, such as the default mode network (DMN) and task-specific networks...
  98. doi Synthesis, physical properties, and field-effect mobility of isomerically pure syn-/anti-anthradithiophene derivatives
    Masashi Mamada
    Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata, 992 8510 Japan
    Org Lett 14:4062-5. 2012
    Isomerically pure syn-/anti-isomers of 2,8-dimethylanthradithiophene (DMADT) were synthesized in five steps and characterized using thermogravimetry, X-ray single crystal analysis, UV-vis absorption, and electrochemical measurements...
  99. pmc Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine
    Inder Bhamra
    Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK
    Nucleic Acids Res 40:11126-38. 2012
    ..Physicochemical studies demonstrated that 8-nitro-2'-O-methylguanosine adopts a syn conformation about the glycosidic bond; thermal melting studies and molecular modelling suggest a relatively stable ..
  100. doi Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process
    Isabela Tiemy Pereira
    Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil
    Phytother Res 27:1067-73. 2013
    Tabebuia avellanedae (syn. Handroanthus impetiginosus) is popularly known as 'ipê-roxo' and has been used in folk medicine as anti-inflammatory and in the treatment of ulcers, bacterial and fungal infections...
  101. doi Dechlorane Plus flame retardant in terrestrial raptors from northern China
    Da Chen
    Key Laboratory of Ecology and Environmental Science of Guangdong Higher Education, School of Life Science, South China Normal University, Guangzhou 510631, China
    Environ Pollut 176:80-6. 2013
    ..The present study revealed that median ∑DP (including anti- and syn-DP isomers) concentrations ranged from 10 to 810 ng/g lipid weight in muscle and liver tissues of six terrestrial ..

Research Grants75

  1. Single-molecule study of alpha-synuclein structure modulation by interactions
    CRYSTAL ROSE MORAN-GUTIERREZ; Fiscal Year: 2013
    ..in its molecular pathology is the abundantly-expressed and intrinsically disordered protein (IDP) a- synuclein (a -syn)...
  2. Alan M Lambowitz; Fiscal Year: 2016
    ..For group I introns, we focus on the Neurospora crassa mitochondrial tyrosyl-tRNA syn- thetase (mt TyrRS;CYT-18 protein), which we identified genetically as functioning in splicing multiple mt group I ..
  3. MECHANISMS FOR TNF ALPHA IN XENOBIOTIC LIVER INJURY
    Mark Rutherford; Fiscal Year: 2000
    ..Preliminary studies support that TNF-alpha may play a role in dimethylnitrosamine (DMN) toxicity as well...
  4. JASON T GRAVANO; Fiscal Year: 2014
    ..While both mTBI and PTSD show disturbances in the connectivity of the default mode network (DMN;a set of structurally and functionally connected brain regions active at rest), evidence from the literature ..
  5. Judith M Ford; Fiscal Year: 2014
    ..The brain idles in a default mode network (DMN) in which slowly changing activity is temporally correlated between large areas of the brain...
  6. Default mode connectivity in typical development &the schizophrenia prodrome
    SUSANNA FRYER; Fiscal Year: 2013
    ..The "default-mode network" (DMN) is a neural network that shows increased fMRI activity at rest, compared to cognitive task conditions...
  7. Default Mode Interference and Working Memory in Mild Traumatic Brain Injury
    Chandler Sours; Fiscal Year: 2013
    ..groups have demonstrated a number of functionally connected neural networks including the default mode network (DMN) (TPN). During a working memory task, the DMN is suppressed while the TPN is activated...
  8. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..synuclein [-Syn], a member of the synuclein family of proteins, is expressed in monoaminergic neurons, but its function in the ..
  9. Role of complement in alpha-synuclein based models of Parkinson disease
    HEATHER ELIZABETH ALLEN; Fiscal Year: 2013
    ..overexpression of alpha-synuclein in the substantia nigra of mice driven by an adeno-associated virus vector (AAV-SYN) recapitulates the microgliosis and slow progressive cell death observed in human PD...
  10. Howard E Gendelman; Fiscal Year: 2016
    ..and functional immune tests following chronic HIV and/or misfolded and aggregated nitrated alpha synuclein (N-a-syn) exposures...
  11. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ..The importance of the hypothalamic dorsomedial nucleus (DMN) as a relay station between the arcuate nucleus and TRH neurons in the PVN will be explored and the hypothesis ..
  12. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..The major inclusion in degenerating dopaminergic cells (Lewy bodies) contains aggregates of the a-synuclein (a-syn) protein...
  13. R Lee Mosley; Fiscal Year: 2014
    ..In PD, nitrated a-synuclein (N-a-syn) is found aggregated within the cytoplasm and Lewy bodies of dopaminergic neurons within the substantia nigra and ..
  14. Role of Nuclear Gangliosides in Neuronal Function
    Robert W Ledeen; Fiscal Year: 2012
    ..disease (PD), along with mitochondrial impairment, oxidative stress, and aggregation of alpha-synuclein (1-syn)...
  15. ERIC D LAZARTIGUES; Fiscal Year: 2016
    ..2) Identify the role of the SFO and RVLM in the ACE2-mediated reduction of Hypertension in Syn- ACE2 transgenic mice and the molecular consequences of their activation...
  16. Nicholas Muzyczka; Fiscal Year: 2014
    ..In work already published, we showed that expression of human ? synuclein (? syn) in the rat substantia nigra causes reproducible and progressive neurodegeneration of the nitgrolstriatal tract, ..
  17. Development of High Affinity Analogues of Brevenal: Novel Molecular Probes for Ne
    Mary C Wolf; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The trans-syn class of marine polyether natural products produced by marine dinoflagellates are some of the most potent non-macromolecular biologicals known...
  18. Novel mechanism of neuroprotection against neurotoxins
    Jianhua Zhang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Accumulation of alpha-synuclein (1-syn) is a shared pathological feature among a group of neurodegenerative diseases collectively referred to as 'synucleinopathies', the most common of ..
  19. A Total Synthesis of Gambierol Using an Epoxide-Opening Cascade Approach
    DENISE ANN COLBY; Fiscal Year: 2010
    ..The hallmark structural features of marine ladder polyethers include a series of syn/trans/syn fused cyclic ethers possessing C-C-O (carbon-carbon-oxygen) connectivity throughout the polyether ..
  20. Investigating Neuroprotective Targets for Parkinson Disease Associated with Autop
    Guy A Caldwell; Fiscal Year: 2011
    ..genetic factors that mediate clinical hallmarks of PD, including intracellular aggregation of a-synuclein (a-syn) and dopamine (DA) neuron loss...
  21. Translesion DNA synthesis in humans
    Louise Prakash; Fiscal Year: 2012
    ..Specifically, these studies will examine how Ub-PCNA promotes synthesis by Pol eta through a cis-syn TT dimer when a processively moving Pol delta has become stalled at the lesion site...
  22. Mechanisms of protection against alpha-synuclein-induced oxidative stress
    Stephan N Witt; Fiscal Year: 2012
    ..long-term objective of this project is to understand the mechanism by which phosphorylation of alpha-synuclein (1-syn) enhances the toxicity of this neuroprotein...
  23. Jianhua Zhang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): a-synuclein (a-syn) mutations or gene amplification cause a small subset of Parkinson's disease (PD), with Lewy body (LB) formation, neurodegeneration and often an associated dementia...
  24. DAVID HASTINGS CRIBBS; Fiscal Year: 2016
    ..Careful neuropathological studies have shown that aggregations of [unreadable]-syn, A[unreadable] and tau appear in the same neuronal structures, providing a pathological basis for the clinical ..
  25. The role of FGF signaling in neuroendocrine control of reproduction
    Nelly Pitteloud; Fiscal Year: 2012
    ..The coordinate spatial and temporal expression of several genes within the FGF signaling pathway -FGF8 syn- expression group- suggests an evolutionarily conserved genetic network, including inhibitors and enhancers of FGF8 ..
  26. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..oxidative stress, inherited defects in turnover of the presynaptic and Lewy Body constituent protein a-synuclein (SYN), and involvement of cytosolic dopamine...
  27. Pleiotrophin for Neurorestoration in Parkinson's Disease
    SARA ELIZABETH GOMBASH LAMPE; Fiscal Year: 2013
    ..of PTN overexpression following significant DA neuron and terminal loss by [unreadable]-synuclein ([unreadable]-syn) overexpression...
  28. Aneel K Aggarwal; Fiscal Year: 2014
    ..to determine how Pol? mediates proficient and error-free replication through DNA lesions such as a UV induced cis-syn TT dimer, an 8-oxoguanine formed from oxidative damage, and a cisplatin G-G crosslink formed upon cisplatin ..
  29. NIKOLAUS RENZ MCFARLAND; Fiscal Year: 2014
    ..Alpha- synuclein ([unreadable]Syn) is a principal component of Lewy bodies found pathologically in Parkinson disease (PD) and related disorders, such ..
  30. Lijun Xia; Fiscal Year: 2014
    ..this hypothesis, we developed mice lacking either core 1- or combined core 1- and core 3-derived O-glycans (IEC T-syn-/- and DKO mice, respectively)...
  31. Lir Wan Fan; Fiscal Year: 2016
    ..by a sustained elevation in IL-1[unreadable] levels, accumulation of [unreadable] -synuclein ([unreadable]- SYN) aggregation, activation of microglia, and induction of cyclooxygenases-2 (COX-2) in the SN...
  32. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ....
  33. Vesicle trafficking defects &mitochondrial dysfunction related to a-syn toxicity
    PAVAN KUMAR AULUCK; Fiscal Year: 2013
    ....
  34. GATA2 as a therapeutic target in Parkinson's disease
    MAX PARVEN HOROWITZ; Fiscal Year: 2013
    ..by applicant): Parkinson's disease (PD) is associated with pathological increases in iron and 1-synuclein (1-syn) in the substantia nigra (SN), and these features are reproduced animal models of PD that use the pesticide ..
  35. Marcus E Raichle; Fiscal Year: 2016
    ..human studies is the unique susceptibility of particular brain regions, particularly the "default mode network" (DMN) of the brain, to A[unreadable] deposition in AD and cortical volume loss in diabetes...
  36. a-Synuclein and Dopamine: Implications of Parkinsonism
    Ruth G Perez; Fiscal Year: 2010
    ..The small protein, D-synuclein (a-Syn), is implicated in PD by its abundance in Lewy bodies and by geo 14-3-3 chaperones to regulate the activity of key ..
  37. RNA Targeted Screens of the Prion 5'UTR
    Jack T Rogers; Fiscal Year: 2010
    ..screens with in-house stably transfected neural cell lines that each express the APP 5'UTR-luciferase and 1-syn 5'UTR-luciferase as key counter targets...
  38. Variations in lipid homeostasis and signaling affect alpha-synuclein pathobiology
    Daniel J Termine; Fiscal Year: 2012
    ..of neurodegenerative disease characterized by pathological lesions composed of aggregates of alpha-synuclein (alpha-syn) in select populations of neurons...
  39. Role of human DNA polymerase kappa in replicative bypass of DNA lesions
    Satya Prakash; Fiscal Year: 2013
    ..TLS opposite these DNA lesions, in Aim 3, we will determine crystal structures of Pol? with 8-oxoG, TG, and cis-syn TT dimer, as well as with the N2-dG minor groove adducts of (r)-3HOPdG, HNE, and BPDE...
  40. To Feed or Breed? GnIH-3 Stimulates Food Intake in Rats
    Gregory Scott Fraley; Fiscal Year: 2013
    ..One hypothalamic structure, the dorsomedial nucleus (DMN), is known to regulate food intake...
  41. JOEL SYNES PERLMUTTER; Fiscal Year: 2016
    ..This is a particular challenge in PD since dementia may be caused by either underlying cortical a-synuclein (a-syn) pathology or co-existing Alzheimer's (AD) pathology that includes abnormal deposition of A[unreadable] and ..
  42. Cathepsin D as a therapeutic tool for Parkinson's disease
    Daniel Sevlever; Fiscal Year: 2012
    ..of brain inclusions known as Lewy bodies and Lewy neurites that are primarily composed of fibrillar 1-synuclein (1- syn)...
  43. Alpha-Synuclein Isomers as Novel Immunogens for Immunotherapy of Parkinsons Disea
    ROWEN JY CHANG; Fiscal Year: 2010
    ..Human a-Synuclein (a-Syn) is a recognized protein marker for the potential intervention of PD...
  44. Eunsung Junn; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): a-Synuclein (a-Syn) is a key protein in the pathogenesis of Parkinson's disease (PD) and other a- synucleinopathies...
  45. Specification of anterioposterior polarity in the mosquito, Chironomus
    URS C SCHMIDT-OTT; Fiscal Year: 2012
    ..that determines anterior-to-posterior (AP) polarity in embryos of the culicomorphan mosquito Chironomus riparius (syn. C. thummi)...
  46. William J Jagust; Fiscal Year: 2016
    ..to external or internal stimuli, and that it performs thi function by coupling to the default mode network (DMN) during internal processing or the dorsal attention network (DAN) during attention to external stimuli...
  47. Pesticide Interactions in LRRK2 Transgenic Models
    AMY BEATRICE MANNING BOG; Fiscal Year: 2010
    ..e. tau and 1-syn), in both transgenic and wildtype mice...
  48. Pathological interactions of a-syn, mitochondria, and pesticides in PD models
    Michael K Lee; Fiscal Year: 2010
    ..pathological relationships between mitochondrial dysfunction, oxidative stress and alpha-synucleinopathies in Hua-Syn Tg mice and in cell models (Aims 1 and 2)...
  49. Nancy J Donovan; Fiscal Year: 2014
    ..social cognition, such as loneliness, may be associated with connectivity disruptions in the default mode network (DMN) linked to early AD related pathology and clinical decline...
  50. JEFFREY SCOTT WEFEL; Fiscal Year: 2016
    ..The default mode network (DMN) is a brain circuit important for normal cognitive function...
  51. Wanda F Reynolds; Fiscal Year: 2015
    ..loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) with accumulation of a-synuclein (a-syn) in aggregates and Lewy bodies. Oxidative stress is implicated as a causative factor...
  52. Bruce R Rosen; Fiscal Year: 2015
    ..These networks include the executive attention network (EAN) and "default mode network" (DMN), a network thought to underlie self-referential cognition and modulated by acupuncture...
  53. PAULA ALEJANDRA DESPLATS; Fiscal Year: 2016
    ..is associated with progressive accumulation of Amyloid-beta (A[unreadable]), [unreadable]-synuclein ([unreadable]-syn) and Tau in the CNS of aged HIV human cases and in transgenic (tg) mice expressing HIV-gp120 protein (GFAP-gp120 tg)..
  54. Intrinsic currents modulate synaptic integration in dopamine neurons
    CARMEN CASTRO CANAVIER; Fiscal Year: 2013
    ..The overall objective is to characterize the contribution of the intrinsic properties of dopamine neurons to syn- aptic integration...
  55. James Shorter; Fiscal Year: 2016
    ..Indeed, we have established Hsp104 as the only cellular factor known to dissociate ?-synuclein (?-syn) oligomers and amyloids and rescue ?-syn-induced neurodegeneration in the substantia nigra of a rat PD model...
  56. Kiki D Chang; Fiscal Year: 2014
    ..We will use resting state-fMRI (rs-fMRI) to examine default mode networks (DMN) in these 30 subjects and compare with already acquired data from 20 healthy controls (HC)...
  57. John Morris; Fiscal Year: 2016
    ..human brain it is strikingly nonuniform in its distribution being highest the brain's default mode network (DMN)...
  58. Harry Ischiropoulos; Fiscal Year: 2014
    ..a-Synuclein (a- syn) has been identified as one of the major components of the protein inclusions in the brains of subjects with ..
  59. Dimitri Krainc; Fiscal Year: 2015
    ..disease (PD), are a group of neurodegenerative disorders characterized by the accumulation of alpha-synuclein (a-syn), a small neural- specific protein that aberrantly aggregates into amyloid fibrils that comprise Lewy bodies, the ..
  60. Toxicant, oxidative injury, dopamine & synuclein in PD
    KATHLEEN ANNE MAGUIRE ZEISS; Fiscal Year: 2011
    ..a compound transgenic mouse to specifically overexpress human wild type a-synuclein in dopaminergic cells (SYN+/+) on the background of glial depleted glutathione peroxidase 1 (GPX-/-) and an antioxidant promoter-reporter...
  61. John Q Trojanowski; Fiscal Year: 2016
    ..central nervous system (CNS) degeneration mediated by progressive accumulations of pathological alpha-synuclein (a-syn)...
  62. Isotropic Reinforcement to Minimize Nigrostriatal Degeneration
    AMY BEATRICE MANNING-BOG; Fiscal Year: 2013
    ..research indicate that oxidative stress contributes to pathogenesis in PD and the development of alpha-synuclein (a-syn) pathology. However, studies utilizing anti-oxidants show little efficacy...
  63. NMR STUDIES OF BIOLOGICAL MEMBRANES
    Judith Herzfeld; Fiscal Year: 2012
    ..the blue light pdriven pump of the D85N mutant of bacteriorhodopsin, and the transport incompetent 13-cis,15-syn isomer of bacteriorhodopsin...
  64. Endoplasmic Reticulum Stress and Parkinson's Disease
    David Ron; Fiscal Year: 2004
    ..g. a-SYN mutations) or indirectly, by affecting cellular processes that impact on the accumulation of proteotoxins (e.g...
  65. Understanding the Effect of N-Terminal Acetylation on alpha-Synuclein Toxicity
    JENNIFER BEIERLEIN; Fiscal Year: 2013
    ..neurodegenerative movement disorder, whose clinical markers include the formation of alpha-Synuclein (alpha-Syn) rich aggregates in the substantia nigra ...
  66. Michael R Sierks; Fiscal Year: 2014
    ..of a specific protein;beta-amyloid (abeta) with AD, tau with AD and other tauopathies, alpha- synuclein (a-syn) with PD and LBD, more than one protein is likely to misfold and aggregate in brain tissue complicating diagnosis ..
  67. SHAWN DENVER BURTON; Fiscal Year: 2015
    ..The influence of mitral cell syn- chrony on granule cell recruitment will then be directly examined using paired mitral cell recordings coupled with ..
  68. Mechanisms of Tauopathies and Synucleopathies
    Anita Sidhu; Fiscal Year: 2012
    ..disease [PD] and other taupathies, is also found in certain synucleopathies, while conversely, a-synuclein [a-Syn], a presynaptic protein linked to Parkinson's disease, is found not only in synucleopathies but also in ..
  69. Jeffrey Skolnick; Fiscal Year: 2015
    ..of the structural and functional properties of native proteins with artificially generated, homopolypeptide "SYN" protein structures to which protein-like sequences are added based on their stability in a particular fold...
  70. PROTEIN BINDING DOMAINS ON EUKARYOTIC 5S RRNA AND RDNA
    Paul Huber; Fiscal Year: 2000
    ..The syn- thesis of 5S rRNA is primarily mediated by the zinc finger transcription factor TFIIIA which has the distinctive ..
  71. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ..which induce a vagal-dependent stimulation of gastric function when injected into the dorsal motor nucleus (DMN) of the vagus...
  72. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD LECHAN; Fiscal Year: 2007
    ..The importance of the hypothalamic dorsomedial nucleus (DMN) as a metabolic sensor for TRH neurons in the PVN will be explored, and the hypothesis tested that the DMN ..
  73. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..Neuronal and synaptic integrity will be evaluated by immunoquantification of synaptophysin (SYN, synaptic marker) and microtubule associated protein 2 (MAP2, dendritic marker)...
  74. Role of Protein-Lipid Bilayer Interactions in alpha-Syn*
    Anneta Razatos; Fiscal Year: 2005
    ..The AFM will also be used to observe the formation of alphaS aggregates on lipid bilayers. Ultimately, results from this study will be used to develop therapies that prevent alphaS aggregation. ..
  75. Asymmetric Synthesis of Amino Acids and Amino Phosphonic Acids
    FRANKLIN DAVIS; Fiscal Year: 2007
    ..Sulfinimine derived syn- and anti-2,[unreadable]-diamino esters are expected to provide access to several biorelevant diamino compounds ..