synaptophysin

Summary

Gene Symbol: synaptophysin
Description: synaptophysin
Alias: MRX96, MRXSYP, synaptophysin, major synaptic vesicle protein P38
Species: human

Top Publications

  1. doi Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats
    Li hong Zhao
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Eur J Pharmacol 647:68-74. 2010
  2. ncbi Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus
    K Sharma
    Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Brain Res 1132:10-9. 2007
  3. ncbi The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine
    Haiyun Xu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurochem 91:1380-8. 2004
  4. doi Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin
    Huai Cai Zeng
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Synapse 65:225-33. 2011
  5. doi Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice
    Shaokuan Fang
    Department of Neurology, The First Teaching Hospital of Jilin University, Changchun, People s Republic of China
    Biochem Cell Biol 88:655-63. 2010
  6. doi Epileptiform discharge upregulates p-ERK1/2, growth-associated protein 43 and synaptophysin in cultured rat hippocampal neurons
    Zu Cai Xu
    Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Seizure 18:680-5. 2009
  7. ncbi Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats
    R Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Neuroscience 149:739-46. 2007
  8. ncbi Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
    T Tauchi
    First Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan
    Blood 87:4495-501. 1996
  9. ncbi Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    T Kimura
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:4426-34. 1997
  10. pmc An intricate network of regulators controls biofilm formation and colonization by Vibrio fischeri
    Karen L Visick
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153, USA
    Mol Microbiol 74:782-9. 2009

Research Grants

  1. Robert E Marc; Fiscal Year: 2016
  2. MONICA P COLAIACOVO; Fiscal Year: 2016
  3. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    Karen L Visick; Fiscal Year: 2013
  4. Judith L Yanowitz; Fiscal Year: 2016
  5. TYROSINE PHOSPHORYLATION AND MAMMALIAN RETINA
    ABBOUD GHALAYINI; Fiscal Year: 2001
  6. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
  7. BCR KINASE IN PDGF-MED EFFECTS IN VASCULAR SMOOTH MUSCLE
    Jun Ichi Abe; Fiscal Year: 2002
  8. ALTERED EGF RECEPTORS IN HUMAN GLIAL TUMORS
    Albert Wong; Fiscal Year: 2001
  9. SYP AND GRB2 AND PDGF TRANSFORMATION
    BRUCE BEJCEK; Fiscal Year: 2000
  10. PRIMARY EPO SIGNALS FOR PROERYTHROID CELL EXPANSION
    Don Wojchowski; Fiscal Year: 2002

Detail Information

Publications193 found, 100 shown here

  1. doi Cornel iridoid glycoside improves memory ability and promotes neuronal survival in fimbria-fornix transected rats
    Li hong Zhao
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, PR China
    Eur J Pharmacol 647:68-74. 2010
    ..of nerve growth factor (NGF), tyrosine receptor kinase A (Trk A), brain-derived neurotrophic factor (BDNF), synaptophysin (SYP) and B-cell lymphoma-2 (Bcl-2), but not levels of tyrosine receptor kinase B (Trk B) and growth-..
  2. ncbi Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus
    K Sharma
    Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Brain Res 1132:10-9. 2007
    ..Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic AMP responsive element-binding (p-CREB) ..
  3. ncbi The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine
    Haiyun Xu
    Neuropsychiatry Research Unit, Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Neurochem 91:1380-8. 2004
    ..of neural plasticity in rat hippocampus, we examined two structural proteins involved in neuronal plasticity, synaptophysin (SYP) and microtubule-associated protein 1 (MAP1) for their response to repeated restraint stress and ..
  4. doi Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin
    Huai Cai Zeng
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Synapse 65:225-33. 2011
    ..The mRNA levels of synapsin1 (Syn1), synapsin2 (Syn2), and synaptophysin (Syp) were decreased in treated groups either on PND0 or on PND21...
  5. doi Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice
    Shaokuan Fang
    Department of Neurology, The First Teaching Hospital of Jilin University, Changchun, People s Republic of China
    Biochem Cell Biol 88:655-63. 2010
    ..Our preliminary data found that 5 mg.kg-1.d-1 of venlafaxine treatment prevented decreased synaptophysin (SYP) in the hippocampus, which results from chronic restrained stress in the rat model...
  6. doi Epileptiform discharge upregulates p-ERK1/2, growth-associated protein 43 and synaptophysin in cultured rat hippocampal neurons
    Zu Cai Xu
    Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Seizure 18:680-5. 2009
    ..The expressions of p-ERK1/2, C-fos, growth-associated protein 43 (GAP-43) and synaptophysin (SYP), as markers of axon growth and synapse reorganization, were investigated by double-label ..
  7. ncbi Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats
    R Wang
    Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
    Neuroscience 149:739-46. 2007
    ..The expression of synaptophysin (SYP) in whole hippocampus was measured by using immunohistochemistry...
  8. ncbi Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis
    T Tauchi
    First Department of Internal Medicine, Tokyo Medical College, Tokyo, Japan
    Blood 87:4495-501. 1996
    ..Moreover, Y425 in the EpoR reduces the Epo requirement for Syp tyrosine phosphorylation and promotes proliferation...
  9. ncbi Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor
    T Kimura
    Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 159:4426-34. 1997
    ..Thus, unlike other immune cells in which inhibitory molecules are recruited by accessory proteins, Fc epsilonRI bind molecules that both activate and inhibit signal transduction...
  10. pmc An intricate network of regulators controls biofilm formation and colonization by Vibrio fischeri
    Karen L Visick
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL 60153, USA
    Mol Microbiol 74:782-9. 2009
    ..The wealth of regulators and the correlation between biofilm formation and colonization adds to the already considerable utility of the V. fischeri-E. scolopes model system...
  11. pmc The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells
    Christopher Merritt
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Development 137:1787-98. 2010
    ..We propose that parallel regulation by FBF ensures that in wild-type gonads, meiotic entry is coordinated with just-in-time synthesis of synaptonemal proteins...
  12. pmc A single regulatory gene is sufficient to alter bacterial host range
    Mark J Mandel
    Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, 1550 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 458:215-8. 2009
    ....
  13. pmc A single unpaired and transcriptionally silenced X chromosome locally precludes checkpoint signaling in the Caenorhabditis elegans germ line
    Aimee Jaramillo-Lambert
    Department of Molecular and Cellular Biology, Genetics Graduate Group, University of California, Davis, California 95616, USA
    Genetics 184:613-28. 2010
    ....
  14. ncbi Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp
    G S Feng
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 9:1545-50. 1994
    ..The mouse Syp gene has been mapped to chromosome 5F region by the fluorescence in situ hybridization. These findings suggest specific functions for Syp in signal transduction downstream of receptor tyrosine kinases...
  15. ncbi The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
    ....
  16. pmc A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000669. 2009
    ..Altogether our findings place SYP-4 as a central player in SC formation and broaden our understanding of the structure of the SC and its assembly...
  17. ncbi Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584
    W Vogel
    Department of Molecular Biology, Max Planck Institut für Blochemie, Martinsried, Germany
    Cell Growth Differ 7:1589-97. 1996
    ..Immunoprecipitation of SHP-2 from a panel of mammary carcinoma cell lines copurifies several tyrosine phosphorylated proteins; the most prominent band has an apparent molecular weight of M(r) 115,000...
  18. ncbi The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression
    A Symes
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Biol 7:697-700. 1997
    ..These data suggest that SHP-2 has a negative role in gp130 signaling by modulating STAT-mediated transcriptional activation...
  19. pmc RscS functions upstream of SypG to control the syp locus and biofilm formation in Vibrio fischeri
    Elizabeth A Hussa
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    J Bacteriol 190:4576-83. 2008
    ..Therefore, this work both contributes to our understanding of regulatory pathways important for symbiotic colonization by V. fischeri and establishes a paradigm for evaluating two-component pathways in the genomics era...
  20. pmc The hybrid sensor kinase RscS integrates positive and negative signals to modulate biofilm formation in Vibrio fischeri
    Kati Geszvain
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    J Bacteriol 190:4437-46. 2008
    ..Thus, RscS integrates both inhibitory and stimulatory signals from the environment to regulate biofilm formation by V. fischeri...
  21. doi Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat
    Marco Fuenzalida
    Centro de Neurobiología y Plasticidad del Desarrollo, Departamento de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Chile
    Synapse 63:502-9. 2009
    ..In both control and taiep groups, the synaptophysin immunostaining (SYP-IR) in the stratum radiatum of CA1 region was significantly lower in the juvenile (P30) ..
  22. ncbi [Effect of Panax notoginseng saponins on syp and tau gene expression in brain of senescence accelerated mouse]
    Liang Lv
    Center of Research and Development of New Drugs, Guangxi Chinese Traditional Medical University, Nanning 530001, China
    Zhongguo Zhong Yao Za Zhi 34:1261-3. 2009
    To study the effect of Panax notoginseng saponins (PNS) on (synaptophysin, syp) and tau gene expression in the brain tissue in senescence accelerated mouse prone 8 (SAMP 8).
  23. ncbi Improving the two-step remediation process for CCA-treated wood: Part II. Evaluating bacterial nutrient sources
    Carol A Clausen
    USDA Forest Service, Forest Products Laboratory, One Gifford Pinchot Drive, Madison, WI 53726 2398, USA
    Waste Manag 24:407-11. 2004
    ..The two-step process (oxalic acid extraction and bacterial culture with nutrient medium) appears to be an effective, yet costly, way to remove metals...
  24. pmc SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 176:2015-25. 2007
    ..Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase...
  25. pmc Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis
    Sarit Smolikov
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Genetics 176:2027-33. 2007
    ..Moreover, our studies suggest that the conformation of chromosomes may influence the mode of DSB repair employed during meiosis...
  26. doi Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats
    B Chen
    Luzhou Medical College, Department of Neurobiology, 646000, China
    Brain Res 1284:1-11. 2009
    ..Immunohistochemistry was used to identify implanted cells and observe the expressions of Synaptophysin (Syp) and postsynaptic density-95 (PSD-95) and caspase-3...
  27. doi Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine
    Gang Zhao
    Cell Star Bio Technologies Co, Limited, Shanghai, People s Republic of China
    Neurochem Res 35:666-76. 2010
    ..Thus, SY extracts especially SYc and SYb are novel neurotransmitter-transporter modulators functioning as DAT/NET activators and/or GAT-1/SERT inhibitors...
  28. doi Moderate exercise changes synaptic and cytoskeletal proteins in motor regions of the rat brain
    Ana F B Ferreira
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Brain Res 1361:31-42. 2010
    ..the acute effects of a moderate forced exercise protocol on synaptic proteins, namely synapsin I (SYN) and synaptophysin (SYP), and structural proteins (neurofilaments, NFs) in rat brain regions related to motor function and often ..
  29. ncbi Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen)
    C J Band
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Endocrinol 11:1899-910. 1997
    ....
  30. ncbi The use of the yeast two hybrid system to evaluate ErbB-3 interactions with SH2 domain containing proteins
    J Y Yoo
    Molecular and Cellular Biology Program, University of Maryland, Baltimore, Maryland, 21201, USA
    Biochem Biophys Res Commun 251:903-6. 1998
    ..A double mutant (Asp832Asn, Asp757 His) exhibited a 96 or 350 fold increase in the ability to bind PI3K and Syp...
  31. ncbi Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?
    Flavia Valtorta
    Department of Neuroscience, S Raffaele Scientific Institute and Vita Salute University, Milan, Italy
    Bioessays 26:445-53. 2004
    b>Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned...
  32. doi Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases
    William Sterlacci
    Institute for Pathology, Medical University Innsbruck, Muellerstrasse 44, 6020 Innsbruck, Austria
    Virchows Arch 455:125-32. 2009
    ..tissue microarray platform and the currently recommended antibody panel consisting of chromogranin-A, synaptophysin, and neural-cell adhesion molecule. Diagnostic criteria provided by the World Health Organization were applied...
  33. doi Synaptophysin immunoreactivity in adrenocortical adenomas: a correlation between synaptophysin and CYP17A1 expression
    Kazuto Shigematsu
    Department of Pathology, Japanese Red Cross Nagasaki Atomic Bomb Hospital, Nagasaki 852 8511, Japan
    Eur J Endocrinol 161:939-45. 2009
    ..In this study, we examined synaptophysin (SYP) and neural cell adhesion molecule (NCAM) expression in adrenocortical adenomas in relation to adrenal ..
  34. doi Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues
    Stephan Wierschke
    Charite Universitatsmedizin Berlin, Center for Anatomy, Institute of Cell Biology and Neurobiology, Berlin, Germany
    Biochem Biophys Res Commun 403:385-90. 2010
    ..GAPDH) and hypoxanthine phosphoribosyl-transferase (HPRT) is unstable, whereas synaptophysin (SYP) and neuron-specific enolase (NSE)/mitochondrial 39S ribosomal protein L28 (MRPL) are most stably ..
  35. ncbi Chaperon normal goblet cells intercalated with dysplastic cells in duodenal adenomas express synaptophysin
    Carlos A Rubio
    Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden
    Anticancer Res 32:3411-4. 2012
    ..Goblet cells in the normal duodenum were found to cross-react with the neurotransmitter synaptophysin, a synaptic glycoprotein present in neuroendocrine cells and in virtually all neurons of the central nervous ..
  36. pmc Inhibition of SypG-induced biofilms and host colonization by the negative regulator SypE in Vibrio fischeri
    Andrew R Morris
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, USA
    PLoS ONE 8:e60076. 2013
    ....
  37. doi Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures
    Mi Kyoung Seo
    Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea
    Neuropharmacology 79:222-33. 2014
    ..Postsynaptic density protein-95 (PSD-95), brain-derived neurotrophic factor (BDNF), and synaptophysin (SYP) levels were evaluated using Western blot analyses...
  38. doi Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory
    Jiutao Wang
    College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100, PR China
    Toxicol Lett 232:263-70. 2015
    ..In addition, exposure to SW led to down-regulation of doublecortin (DCX) and synaptophysin (SYP) in the hippocampus...
  39. pmc Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice
    Hui Yu Zhang
    Laboratory of Pathological Sciences, Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Pathology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China
    J Zhejiang Univ Sci B 16:62-9. 2015
    ..The results showed that chronic CORT injection reduced hippocampal neurofilament light protein (NF-L) and synaptophysin (SYP) levels, induced depression-like behavior in male mice, reduced hippocampal glycogen level and glycogen ..
  40. pmc Creatine protects against mitochondrial dysfunction associated with HIV-1 Tat-induced neuronal injury
    Patrick R Stevens
    Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, 504 Hamline St, Grand Forks, North Dakota 58203, USA
    Curr HIV Res 12:378-87. 2014
    ..Additionally, creatine protected against HIV-1 Tat-induced mitochondrial hypopolarization and HIV-1 Tat-induced mitochondrial permeability transition pore opening. Thus, creatine may be a useful adjunctive therapy against HAND...
  41. doi Effects of 5-h multimodal stress on the molecules and pathways involved in dendritic morphology and cognitive function
    Yiran Xu
    Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China
    Neurobiol Learn Mem 123:225-38. 2015
    ..Our results suggest that TGFB1, PLAU, NOTCH3, and CLSTN1 may be related to the alterations in dendritic morphology induced by stress, and imply that the Notch and TGF-B signaling pathways may be involved. ..
  42. pmc Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury
    Yeun Goo Chung
    Urological Diseases Research Center, Boston Children s Hospital, Boston, Massachusetts, United States of America Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 10:e0141492. 2015
    ..At the end of treatment, voiding behavior was assessed by cystometry. Levels of synaptophysin (SYP), neurofilament 200 (NF200) and TRPV1 in bladder tissues were measured by immunofluorescence imaging...
  43. doi Luteimonas notoginsengisoli sp. nov., isolated from rhizosphere soil
    Juan Cheng
    1Shenyang Pharmaceutical University, Shenyang
    Int J Syst Evol Microbiol . 2015
    ..nov. is proposed with SYP-B804T (=KCTC 42211T=JCM 30329T) as the type strain...
  44. pmc Neuroprotective effect of β-asarone against Alzheimer's disease: regulation of synaptic plasticity by increased expression of SYP and GluR1
    Si Jun Liu
    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, People s Republic of China
    Drug Des Devel Ther 10:1461-9. 2016
    ..As the underlying mechanism is not known, we investigated the neuroprotective effects of β-asarone in an APP/PS1 double transgenic mouse model and in NG108 cells...
  45. pmc Penicimenolides A-F, Resorcylic Acid Lactones from Penicillium sp., isolated from the Rhizosphere Soil of Panax notoginseng
    Ya Nan An
    Shenyang Pharmaceutical University, Shenyang 110016, People s Republic of China
    Sci Rep 6:27396. 2016
    ..In addition, compounds 2-4 and 7 exhibited a significant inhibitory effect on NO production induced by LPS. ..
  46. ncbi Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes
    D K Fuhrer
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 270:24826-30. 1995
    ..These findings may have extensive significance to IL-11 and related cytokine signal transduction, suggesting new pathways and mechanisms...
  47. ncbi Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
    R J Lechleider
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts
    J Biol Chem 268:21478-81. 1993
    ..Our data suggest that binding of SH-PTP2 to the activated receptor in vivo should result in stimulation of SH-PTP2 activity...
  48. pmc Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation
    X J Liu
    Loeb Medical Research Institute, Ottawa Civic Hospital, Ontario, Canada
    Mol Cell Biol 15:3563-70. 1995
    ....
  49. ncbi [Studies on polysaccharide of Cynomorium songaricum Rupr]
    S J Zhang
    Institute of Chinese Materia, China Academy of Traditional Chinese Medicine, Beijing 100700, China
    Zhongguo Zhong Yao Za Zhi 26:409-11. 2001
    ..To study the acidic heteropolysac charides of Cynomorium songaricum...
  50. pmc Identification of the syr-syp box in the promoter regions of genes dedicated to syringomycin and syringopeptin production by Pseudomonas syringae pv. syringae B301D
    Nian Wang
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843, USA
    J Bacteriol 188:160-8. 2006
    ..These results demonstrate that the conserved promoter sequences of the syr-syp genes contribute to the coregulation of syringomycin and syringopeptin production...
  51. doi Genomic and non-genomic actions of estrogen on synaptic plasticity in SH-SY5Y cells
    Siriporn Chamniansawat
    Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Neurosci Lett 470:49-54. 2010
    ..Therefore, the estrogen-enhanced synaptic plasticity is ER beta-dependent and involves the crosstalk mechanism of non-genomic and genomic estrogenic actions...
  52. ncbi [GluR2 expression in the developing rat inferior colliculus and the relationship with development of synapse]
    Yuling Shen
    Department of Otolaryngology Head and Neck Surgery, Renji Hospital Affiliated Shanghai Jiaotong University, Shanghai, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:173-6. 2010
    ..To observe the GluR2 expression in rat inferior colliculus (IC) in different developmental stages, and to investigate its developmental change and relationship with the synapse development...
  53. pmc Localization of Arabidopsis SYP125 syntaxin in the plasma membrane sub-apical and distal zones of growing pollen tubes
    Reiaz Ul-Rehman
    Universidade de Lisboa, Faculdade de Ciencias de Lisboa, BioFIG, Lisbon, Portugal
    Plant Signal Behav 6:665-70. 2011
    ..The localization of syntaxins at different membrane domains likely depends on the interaction with specific partners not yet identified...
  54. pmc Inactivation of a novel response regulator is necessary for biofilm formation and host colonization by Vibrio fischeri
    Andrew R Morris
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, USA
    Mol Microbiol 82:114-30. 2011
    ..We conclude that SypE must be inactivated to promote symbiotic colonization by V. fischeri...
  55. doi Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride
    Y Hou
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Neuroscience 200:120-9. 2012
    ..The expression of synaptophysin (SYP) was measured using real-time polymerase chain reaction and western blot analyses; the expression of p-..
  56. doi Different protocols of physical exercise produce different effects on synaptic and structural proteins in motor areas of the rat brain
    Priscila C Garcia
    Physical Therapy Graduate Program, City University of Sao Paulo, Sao Paulo, SP, Brazil
    Brain Res 1456:36-48. 2012
    ..We evaluated the protein expression of synapsin I (SYS), synaptophysin (SYP), microtubule-associated protein 2 (MAP2) and neurofilaments (NF) by immunohistochemistry and Western ..
  57. pmc Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells
    Francisco Javier Sánchez-Martín
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e80558. 2013
    ..We conclude that our ESC-derived model of toxicant exposure during neural differentiation promises to be a useful model to analyze mechanisms of neurotoxicity induced by Pb and other environmental agents. ..
  58. pmc DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease
    Dai Yuki
    1 Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan 2 Research and Development Headquarters, Lion Corporation, 7 2 1 Hirai, Edogawa ku, Tokyo 132 0035, Japan
    Sci Rep 4:7130. 2014
    ..was associated with reduced levels of the postsynaptic protein PSD-95 but not the presynaptic protein synaptophysin. Interestingly, this reduction in PC(18:0/22:6) levels did not correlate with the degrees of Aβ deposition ..
  59. doi Targeted neural differentiation of murine mesenchymal stem cells by a protocol simulating the inflammatory site of neural injury
    Milada Chudícková
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Tissue Eng Regen Med . 2015
    ..for neuronal cell markers, such as neurofilament light (Nf-L), medium (Nf-M) and heavy (Nf-H) polypeptides, synaptophysin (SYP), neural cell adhesion molecule (NCAM), glutamic acid decarboxylase (GAD), neuron-specific nuclear ..
  60. doi Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway
    Jing Gao
    College of Medicine, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Nankai University, Tianjin 300071, China
    Toxicology 337:21-9. 2015
    ..rescue the synapse deficits, which occurred with the down-regulation of NR2B (a subunit of NMDA receptor) and synaptophysin (SYP) in the hippocampus...
  61. pmc Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse
    Daniel J Adams
    Department of MCD Biology, University of Colorado, Boulder, CO 80309
    Sci Rep 5:13659. 2015
    We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle reconstruction...
  62. doi Rosmarinic acid prevents against memory deficits in ischemic mice
    Analu Aragão Fonteles
    Post Graduate Programme in Pharmacology, Department of Physiology and Pharmacology, Fortaleza, Brazil Institute of Biomedicine of Brazilian Semi Arid, Fortaleza, Brazil
    Behav Brain Res 297:91-103. 2016
    ..and western blot, and ELISA assay were used to analyze glial fibrillary acidic protein (GFAP), and synaptophysin (SYP) expression, and BDNF level, respectively...
  63. pmc Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
    Murat Kara
    Department of Medical Genetics, Faculty of Medicine, Muğla Sıtkı Koçman University, Mugla, Turkey
    Int J Exp Pathol 96:332-7. 2015
    ..Thus imidacloprid in high doses causes deterioration in cognitive functions particularly in infant rats, and this deterioration may be associated with changes in the expressions of related genes. ..
  64. ncbi The reciprocal links between synaptophysin serum levels and the prevalence of metabolic syndrome according to selected low-grade inflammation indices and age-related androgen serum level changes in men
    Waldemar Adam Herman
    Outpatients Unit of Endocrine Diseases, Wschowa, Poznan, Poland
    Pol Merkur Lekarski 40:9-14. 2016
    The correlations between synaptophysin (SYP) plasma levels and the brain neurotransmission activity are still not strictly identified...
  65. ncbi In silico analyses for molecular genetic mechanism and candidate genes in patients with Alzheimer's disease
    Lu Mei Chi
    Department of Neurology, China Japan Union Hospital of Jilin University, No 126 Xintai Street, Changchun, 130000, Jilin, China
    Acta Neurol Belg 116:543-547. 2016
    ..B, member 1 (DNAJB1) and heat shock 70 kDa protein 1A (HSPA1A) were in the up-regulated network, while synaptophysin (SYP) and somatostatin (SST) were in the down-regulated network...
  66. ncbi Altered expression and localization of synaptophysin in developing cerebellar cortex of neonatal rats due to maternal diabetes mellitus
    Javad Hami
    Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Ghaffari St, Birjand, Iran
    Metab Brain Dis 31:1369-1380. 2016
    ..b>Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles and is considered as a marker for synaptogenesis ..
  67. doi In vitro differentiation potential of human haematopoietic CD34(+) cells towards pancreatic β-cells
    Manne Mudhu Sunitha
    Stem Cell Laboratory, Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati, 517 507, Andhra Pradesh, India
    Cell Biol Int 40:1084-93. 2016
    ..of differentiated cells were observed on staining with dithizone (DTZ) and expression of PDX1, insulin and synaptophysin was confirmed by immunocytochemistry...
  68. doi SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis
    Li Hui Wang
    Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, PR China
    Eur J Pharmacol 791:560-568. 2016
    ..It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent...
  69. doi Neuroprotective effect of breviscapine on traumatic brain injury in rats associated with the inhibition of GSK3β signaling pathway
    Ling Jiang
    Department of Anesthesiology, Institute of Neurological Disease, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
    Brain Res . 2017
    ..Concomitantly, an enhanced expression of synaptic marker synaptophysin (SYP) together with a weakened expression of pro-apoptotic caspase3 was observed after TBI rats were treated ..
  70. ncbi Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1
    S Vainikka
    Department of Pathology, University of Helsinki, Finland
    J Biol Chem 269:18320-6. 1994
    ..Despite these differences, stimulation of both receptors resulted in increased DNA synthesis...
  71. ncbi Identification of protein-tyrosine phosphatases prevalent in adipocytes by molecular cloning
    W Ding
    Dorrance H Hamilton Research Laboratories, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Biochem Biophys Res Commun 202:902-7. 1994
    ..These data provide insight into PTPase homologs that may have a physiological role in the regulation of phosphotyrosyl turnover in hormone signalling pathways in adipocytes...
  72. ncbi Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22
    M A Pook
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, London, UK
    Hum Mol Genet 2:2129-34. 1993
    ..22, and a further characterisation of this gene will help to elucidate the factors controlling proximal renal tubular function and the development of kidney stones...
  73. ncbi Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints
    R J Sinke
    Department of Human Genetics, University Hospital, Nijmegen, The Netherlands
    Hum Genet 92:305-8. 1993
    ..In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226...
  74. ncbi The C-terminal transmembrane region of synaptobrevin binds synaptophysin from adult synaptic vesicles
    Sowmya V Yelamanchili
    AG Funktionelle Zellbiologie, Centrum für Anatomie, Charité Hochschulmedizin Berlin, Philippstrasse 12, D 10115 Berlin, Germany
    Eur J Cell Biol 84:467-75. 2005
    b>Synaptophysin and synaptobrevin are abundant membrane proteins of neuronal small synaptic vesicles. In mature, differentiated neurons they form the synaptophysin/synaptobrevin (Syp/Syb) complex...
  75. pmc A microfluidic culture platform for CNS axonal injury, regeneration and transport
    Anne M Taylor
    Department of Biomedical Engineering, University of California, Irvine, 204 Rockwell Engineering, Irvine, California 92697, USA
    Nat Methods 2:599-605. 2005
    ..The results presented here demonstrate several experimental paradigms using the microfluidic platform, which can greatly facilitate future studies in axonal biology...
  76. pmc Characterization of a resistance-nodulation-cell division transporter system associated with the syr-syp genomic island of Pseudomonas syringae pv. syringae
    Hyojeung Kang
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843, USA
    Appl Environ Microbiol 71:5056-65. 2005
    ..The PseABC efflux system is the first RND transporter system described for P. syringae, and it has an important role in secretion of syringomycin and syringopeptin...
  77. pmc Characterization of the transcriptional activators SalA and SyrF, Which are required for syringomycin and syringopeptin production by Pseudomonas syringae pv. syringae
    Nian Wang
    Department of Plant Pathology and Microbiology, Texas A and M University, College Station, Texas 77843, USA
    J Bacteriol 188:3290-8. 2006
    ..Both SalA and SyrF resemble other LuxR family proteins in dimerization and interaction with promoter regions of target genes...
  78. ncbi Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    J Neuropathol Exp Neurol 65:592-601. 2006
    ..We examined protein levels of synaptophysin (SYP), synaptotagmin (SYT), and drebrin (DRB) in 5 neocortical regions (anterior cingulate, superior frontal, ..
  79. pmc The symbiosis regulator rscS controls the syp gene locus, biofilm formation and symbiotic aggregation by Vibrio fischeri
    Emily S Yip
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA
    Mol Microbiol 62:1586-600. 2006
    ....
  80. pmc Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts
    Frédéric Massicotte
    Unité de recherche en arthrose, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Arthritis Res Ther 8:R177. 2006
    ..The altered response of OA Obs to IGF-1 may be due to abnormal IGF-1 signaling in these cells. This is mostly linked with abnormal IRS-1/Syp and IRS-1/Grb2 interaction in these cells...
  81. doi Effect of ephedrine on neuronal plasticity of hypoxic-ischemic brain damage in neonatal rats
    Nong Xiao
    Department of Neurology, Children s Hospital of Chongqing Medical University, Chongqing 400014, China
    Neurosci Lett 435:99-102. 2008
    ..Study the effect of ephedrine on neural plasticity of hypoxic ischemic brain damaged (HIBD) in neonatal rats, and explore the underlying molecular mechanism...
  82. doi Synthesis and fungicidal activities of novel indene-substituted oxime ether strobilurins
    Song Tu
    Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People s Republic of China
    J Agric Food Chem 56:5247-53. 2008
    ..Especially, the 6-methylindene-substituted compound 6p was identified as the most promising candidate for further study...
  83. doi NRSF silencing induces neuronal differentiation of human mesenchymal stem cells
    Yinxiang Yang
    Stem Cells and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing, China
    Exp Cell Res 314:2257-65. 2008
    ..genes including brain-derived neurotrophic factor (BDNF), neurogenin 1 (NGN1), neuron-specific enolase (NSE), synaptophysin (SYP), and neuron-specific growth-associated protein (SCG10), as well as expressing mature neuronal marker ..
  84. pmc Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold
    Elisabetta Onelli
    Department of Biology, University of Milan, Milan, Italy
    J Exp Bot 59:3051-68. 2008
    ..Further experiments using ikarugamycin (IKA), an inhibitor of clathrin-dependent endocytosis, and negatively charged nanogold confirmed that distinct endocytic pathways coexist in tobacco protoplasts...
  85. ncbi Immunocytochemical detection of synaptophysin in C57BL/6 mice cochlea during aging process
    Maria Visitación Bartolome
    Department of Ophthalmology and Oto Rhino Laringology, Complutense University of Madrid, Apartado de Correos 60 075, 28080 Madrid, Spain
    Brain Res Rev 60:341-8. 2009
    ..However, little is still known about aging effects on synapses in this receptor. Synaptophysin (Syp) is a 38 kDa Ca2+ binding glycoprotein widely found in presynaptic membrane and vesicles...
  86. doi Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src
    Cinzia Mallozzi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    J Neurochem 111:859-69. 2009
    ..In this study we show that, following peroxynitrite treatment, the synaptic vesicle protein synaptophysin (SYP) can be both phosphorylated and nitrated in a dose-dependent manner...
  87. pmc The cyclic-di-GMP phosphodiesterase BinA negatively regulates cellulose-containing biofilms in Vibrio fischeri
    Christine M Bassis
    Department of Microbiology and Immunology, Loyola University Chicago, 2160 S First Ave, Bldg 105, Rm 3860A, Maywood, IL 60153, USA
    J Bacteriol 192:1269-78. 2010
    ..fischeri inhibits cellulose-dependent biofilm formation and suggests that the production of two different polysaccharides may be coordinated through the action of the cellulose inhibitor BinA...
  88. doi Environmental fate of SYP-1924 residues in rice field
    Xiaodan Zhu
    Institute of Plant and Environmental Protection, Beijing Academy of Agriculture and Forestry Science, 100097 Beijing, China
    Bull Environ Contam Toxicol 84:775-8. 2010
    ..5 days in soil. The ultimate residues of SYP-1924 in rice were found to be below the limits of the detection at level of recommended and 1.5 times recommended dosage with an interval date of 70 days...
  89. doi Abnormal innervation patterns in the anorectum of ETU-induced fetal rats with anorectal malformations
    WeiLin Wang
    Department of Pediatric Surgery, Shengjing Hospital, China Medical University, PR China
    Neurosci Lett 495:88-92. 2011
    ..5), nitric oxide synthases (NOs), neuromuscular junction markers (synaptophysin, SYP), interstitial cells of Cajal (ICC) marker (c-kit) within the terminal rectum were analyzed by ..
  90. pmc Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans
    Kristina Schild-Prufert
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 189:411-21. 2011
    ..elegans...
  91. ncbi [Effect of willed movement therapy on GFAP and SYP expression in rats with cerebral ischemia-reperfusion]
    De Ren Hou
    Department of Neurology, Central South University, Changsha, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1543-6. 2011
    To determine the effect of willed movement on the expression of glial fibrillary acidic protein (GFAP) and synaptophysin (SYP) in adult rats with cerebral ischemia-reperfusion, and explore the mechanism of willed movement in promoting ..
  92. doi Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
    Nokitaka Setsu
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 43:850-7. 2012
    We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewed. Two (2...
  93. pmc Hippocampal drebrin loss in mild cognitive impairment
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Ill 60612, USA
    Neurodegener Dis 10:216-9. 2012
    ..We examined protein levels of presynaptic synaptophysin (SYP) and synaptotagmin (SYT), and postsynaptic drebrin (DRB), a marker for dendritic spine plasticity, in the ..
  94. ncbi Noise control for 24-hour rock drilling in urban area
    Wilson Ho
    Wilson Acoustics Limited, Unit 616, Technology Park, 18 On Lai Street, Shatin, Hong Kong, China
    J Acoust Soc Am 131:3527. 2012
    ..Groundborne noise impact from rock drilling was predicted within the statutory criteria and verified on site. Construction noise permit for 24-hour rock drilling by 2-boom jumbo drill was obtained...
  95. doi Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats
    Predrag Brkić
    Institute of Medical Physiology Richard Burian, School of Medicine, University of Belgrade, Serbia
    Brain Inj 26:1273-84. 2012
    ..To investigate whether hyperbaric oxygenation (HBO) can improve the recovery of motor functions in rats after suction ablation of the right sensorimotor cortex...
  96. pmc Roles of the structural symbiosis polysaccharide (syp) genes in host colonization, biofilm formation, and polysaccharide biosynthesis in Vibrio fischeri
    Satoshi Shibata
    Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA
    J Bacteriol 194:6736-47. 2012
    ..fischeri to enhance cell-cell interactions and promote symbiotic colonization...
  97. doi Photodegradation of the isoxazolidine fungicide SYP-Z048 in aqueous solution: kinetics and photoproducts
    Pengfei Liu
    College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People s Republic of China
    J Agric Food Chem 60:11657-63. 2012
    ....
  98. pmc The response regulator SypE controls biofilm formation and colonization through phosphorylation of the syp-encoded regulator SypA in Vibrio fischeri
    Andrew R Morris
    Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, USA
    Mol Microbiol 87:509-25. 2013
    ..This study demonstrates that regulation of SypA activity by SypE is a critical mechanism by which V. fischeri controls biofilm development and symbiotic colonization...
  99. pmc Detection and organ-specific ablation of neuroendocrine cells by synaptophysin locus-based BAC cassette in transgenic mice
    Chieh Yang Cheng
    Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 8:e60905. 2013
    ..Here we identify a regulatory region sufficient for accurate in vivo expression of synaptophysin (SYP), a common marker of neuroendocrine differentiation, and report generation of Tg(Syp-EGFP(loxP)-DTA)147(..
  100. doi Histomorphometric and immunohistochemical study of the goat abomasum during prenatal development
    A Garcia
    Department of Veterinary Histology, Faculty of Veterinary Medicine, University of Extremadura, Caceres, Spain
    Histol Histopathol 28:1639-49. 2013
    ..Neuroendocrine cells were detected by synaptophysin (SYP) at 64 days (CRL 13...
  101. pmc The syp enhancer sequence plays a key role in transcriptional activation by the σ54-dependent response regulator SypG and in biofilm formation and host colonization by Vibrio fischeri
    Valerie A Ray
    Department of Microbiology and Immunology, Loyola University, Chicago, Illinois, USA
    J Bacteriol 195:5402-12. 2013
    ..It may also provide useful insights into other bacteria, such as Vibrio vulnificus and Vibrio parahaemolyticus, that have syp-like loci and conserved SE sequences. ..

Research Grants19

  1. Robert E Marc; Fiscal Year: 2016
    ..Aim 1. Generate10 terabyte (TB) retinal connectomes for the C57Bl/6J and the YFP-synaptophysin C57Bl/6J mouse (B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J)...
  2. MONICA P COLAIACOVO; Fiscal Year: 2016
    ..The proposed research will investigate the molecular mechanisms promoting accurate meiotic chromosome segregation thereby laying the foundation for the development of effective preventive strategies. ..
  3. REQUIREMENTS FOR BACTERIAL COLONIZATION OF ANIMAL TISSUE
    Karen L Visick; Fiscal Year: 2013
    ....
  4. Judith L Yanowitz; Fiscal Year: 2016
    ..These complementary approaches will provide significant insights into a surveillance system that monitors crossover formation on each chromosome and allows for timely progression through meiosis. ..
  5. TYROSINE PHOSPHORYLATION AND MAMMALIAN RETINA
    ABBOUD GHALAYINI; Fiscal Year: 2001
    ....
  6. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..abstract_text> ..
  7. BCR KINASE IN PDGF-MED EFFECTS IN VASCULAR SMOOTH MUSCLE
    Jun Ichi Abe; Fiscal Year: 2002
    ..We propose that Bcr is a novel downstream component of PDGF receptor signaling in vascular smooth muscle, and may be a candidate gene responsible for the atherosclerosis and restenosis. ..
  8. ALTERED EGF RECEPTORS IN HUMAN GLIAL TUMORS
    Albert Wong; Fiscal Year: 2001
    ..The structure of alternative transcripts from the Gab1 gene in tumors will be determined and their effects on transformation and signaling will be evaluated. ..
  9. SYP AND GRB2 AND PDGF TRANSFORMATION
    BRUCE BEJCEK; Fiscal Year: 2000
    ..These experiments will add significantly to our understanding of the mechanisms involved in PDGF transformation and tumorigenesis. ..
  10. PRIMARY EPO SIGNALS FOR PROERYTHROID CELL EXPANSION
    Don Wojchowski; Fiscal Year: 2002
    ..Insight into regulation of PCD gained from studies of Epo signaling should extend to related clinically important cytokine systems. ..
  11. SYP PHOSPHATASE AND SIGNAL TRANSDUCTION
    Gen Sheng Feng; Fiscal Year: 2000
    ..It will help us to understand the origin of cancer cells and to design new types of anti-cancer drugs. ..
  12. PATHOGENESIS, IMMUNODIAGNOSIS, AND THERAPY OF HCC
    Jack Wands; Fiscal Year: 1999
    ..These efforts will provide new information on the viral and cellular mechanisms of hepatocarcinogenesis and the role of overexpression of genes such as IRS-1 and p36 during this process. ..
  13. TYROSINE PHOSPHATASES IN SIGNAL TRANSDUCTION
    ZHIZHUANG ZHAO; Fiscal Year: 2000
    ....
  14. VASCULAR ENDOTHELIAL CELL GROWTH FACTOR IN PATHOLOGY
    David Donner; Fiscal Year: 2001
    ..The role of such phosphatases, two in particular- SYP and LAR, in modulating VEGF signaling and cellular responses to VEGF will be defined. ..
  15. MEIOSIS GORDON CONFERENCE
    Anne Villeneuve; Fiscal Year: 2002
    ..The Meiosis Gordon Conference thus provides the most important forum for presenting and discussing new findings regarding a process that is central to sexual reproduction and to maintenance of genome integrity. ..
  16. Cell Signaling in Meiosis
    JoAnne Engebrecht; Fiscal Year: 2005
    ..abstract_text> ..
  17. Symbiotic colonization of host mucus by Vibrio fischeri
    Mark Mandel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Synaptic Apoptosis in Schizophrenia
    LEISA GLANTZ; Fiscal Year: 2008
    ..abstract_text> ..
  19. Analysis of checkpoint function in the germ line.
    JoAnne Engebrecht; Fiscal Year: 2010
    ..Our studies are aimed at understanding how errors arise during this process. In humans, such errors result in infertility, pregnancy loss and birth defects such as Down Syndrome. ..