survivin

Summary

Gene Symbol: survivin
Description: baculoviral IAP repeat containing 5
Alias: API4, EPR-1, baculoviral IAP repeat-containing protein 5, apoptosis inhibitor 4, apoptosis inhibitor survivin, survivin variant 3 alpha
Species: human

Top Publications

  1. ncbi A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    G Ambrosini
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 3:917-21. 1997
  2. pmc Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
    Takehiko Dohi
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Clin Invest 114:1117-27. 2004
  3. ncbi Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
    A Arockia Jeyaprakash
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 131:271-85. 2007
  4. ncbi Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 10:1319-28. 2000
  5. pmc HBXIP functions as a cofactor of survivin in apoptosis suppression
    Hiroyuki Marusawa
    The Burnham Institute, La Jolla, CA 92037, USA
    EMBO J 22:2729-40. 2003
  6. pmc Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis
    Reiko Honda
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Mol Biol Cell 14:3325-41. 2003
  7. ncbi Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential
    Roland H Stauber
    Department of Otorhinolaryngology, Molecular and Cellular Oncology, University of Mainz, Mainz, Germany
    Cancer Res 67:5999-6002. 2007
  8. ncbi Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor
    Claus Rodel
    Department of Radiation Oncology, University of Erlangen, Erlangen, Germany
    Int J Radiat Oncol Biol Phys 55:1341-7. 2003
  9. ncbi An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:7545-51. 2004
  10. doi Survivin expression in breast carcinoma: correlation with apoptosis and prognosis
    Aziza Nassar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Appl Immunohistochem Mol Morphol 16:221-6. 2008

Detail Information

Publications280 found, 100 shown here

  1. ncbi A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    G Ambrosini
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 3:917-21. 1997
    ..Here, we describe a new human gene encoding a structurally unique IAP apoptosis inhibitor, designated survivin. Survivin contains a single baculovirus IAP repeat and lacks a carboxyl-terminal RING finger...
  2. pmc Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
    Takehiko Dohi
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Clin Invest 114:1117-27. 2004
    ..Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel ..
  3. ncbi Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
    A Arockia Jeyaprakash
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell 131:271-85. 2007
    ..The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its ..
  4. ncbi Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
    A G Uren
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia
    Curr Biol 10:1319-28. 2000
    b>Survivin is a mammalian protein that carries a motif typical of the inhibitor of apoptosis (IAP)proteins, first identified in baculoviruses...
  5. pmc HBXIP functions as a cofactor of survivin in apoptosis suppression
    Hiroyuki Marusawa
    The Burnham Institute, La Jolla, CA 92037, USA
    EMBO J 22:2729-40. 2003
    b>Survivin is an anti-apoptotic protein that is overexpressed in most human cancers...
  6. pmc Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis
    Reiko Honda
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Mol Biol Cell 14:3325-41. 2003
    ..have investigated the regulation of human Aurora B by its complex partners inner centromere protein (INCENP) and survivin. We found that overexpression of a catalytically inactive, dominant-negative mutant of Aurora B impaired the ..
  7. ncbi Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential
    Roland H Stauber
    Department of Otorhinolaryngology, Molecular and Cellular Oncology, University of Mainz, Mainz, Germany
    Cancer Res 67:5999-6002. 2007
    b>Survivin's proposed dual role as an apoptosis inhibitor and a mitotic effector positioned it in the front line of cancer research...
  8. ncbi Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor
    Claus Rodel
    Department of Radiation Oncology, University of Erlangen, Erlangen, Germany
    Int J Radiat Oncol Biol Phys 55:1341-7. 2003
    ..Recently, a novel member of the inhibitor of apoptosis protein family, designated survivin, was identified...
  9. ncbi An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy
    Ningxi Zhu
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 23:7545-51. 2004
    b>Survivin is a unique member of the inhibitor of apoptosis protein family, and its expression is regulated by p53...
  10. doi Survivin expression in breast carcinoma: correlation with apoptosis and prognosis
    Aziza Nassar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Appl Immunohistochem Mol Morphol 16:221-6. 2008
    b>Survivin is a novel inhibitor of apoptosis commonly detected in tissues during fetal development and in cancer, but not usually in normal tissues...
  11. doi Polymorphisms of survivin promoter are associated with risk of esophageal squamous cell carcinoma
    Xiaoya Yang
    Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Chongqing 400038, People s Republic of China
    J Cancer Res Clin Oncol 135:1341-9. 2009
    b>Survivin is undetectable in normal adult tissues, but has been shown to be overexpressed in various cancers and has been regarded as a marker of malignancy...
  12. pmc Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma
    Claudia Augello
    Department of Medicine, Surgery and Dentistry, Division of Pathology, University of Milan, AO S Paolo e Fondazione IRCCS Ospedale Maggiore Policlinico, Regina Elena e Mangiagalli, Milan, Italy
    BMC Cancer 9:125. 2009
    ..This study aimed to investigate the gene and protein expression pattern of IAP family members and their antagonists in a series of human HCCs and to assess their clinical significance...
  13. doi Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer
    Xiao Yuan Chu
    Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China
    J Surg Oncol 105:520-8. 2012
    The aim of this study was to investigate the association of survivin expression with metastasis of colorectal cancer (CRC).
  14. pmc Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression
    A Krieg
    Institute of Pathology, Heinrich Heine University, Moorenstr 5, D 40225, Duesseldorf, Germany
    Br J Cancer 86:737-43. 2002
    b>Survivin is a novel member of the inhibitor of apoptosis family and determines the susceptibility of tumour cells to pro-apoptotic stimuli...
  15. pmc Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential
    S Khan
    Division of Biochemistry and Microbiology, Department of Basic Sciences, Center for Health Disparities Research and Molecular Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Br J Cancer 100:1073-86. 2009
    ..Here we show survivin, a member of the inhibitor of apoptosis protein (IAP) family, implicated in apoptosis inhibition and the ..
  16. ncbi Hsp60 regulation of tumor cell apoptosis
    Jagadish C Ghosh
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachustetts 01605, USA
    J Biol Chem 283:5188-94. 2008
    ..Using high throughput proteomics screening, we identified the cell cycle regulator and apoptosis inhibitor survivin as a novel protein associated with the molecular chaperone Hsp60...
  17. ncbi Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
    M A Verdecia
    Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Struct Biol 7:602-8. 2000
    b>Survivin is a 16.5 kDa protein that is expressed during the G2/M phase of the cell cycle and is hypothesized to inhibit a default apoptotic cascade initiated in mitosis...
  18. ncbi Survivin: role in normal cells and in pathological conditions
    L O'Driscoll
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Curr Cancer Drug Targets 3:131-52. 2003
    b>Survivin, an inhibitor of apoptosis (IAP) containing one baculovirus IAP repeat (BIR) domain, has been reported to be capable of regulating both cellular proliferation and apoptotic cell death...
  19. pmc Regulation of survivin function by Hsp90
    Paola Fortugno
    Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:13791-6. 2003
    ..Here, we show that Hsp90, a molecular chaperone that is central to the cellular stress response, associates with survivin, an apoptosis inhibitor and essential regulator of mitosis...
  20. ncbi Survivin gene expression in granulosa cells from infertile patients undergoing in vitro fertilization-embryo transfer
    Kuniko Fujino
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Fertil Steril 89:60-5. 2008
    To evaluate survivin gene expression in granulosa cells from infertile patients and examine the relationship between survivin gene expression and infertile clinical background.
  21. doi Survivin expression in renal cell carcinoma
    Rosanna Zamparese
    Department of Surgical Sciences, University of Foggia, Foggia, Italy
    Cancer Invest 26:929-35. 2008
    ..we have investigated, by immunohistochemical technique, the expression and potential prognostic significance of survivin in a series of 49 clear cell type renal cell carcinoma (ccRCC)...
  22. doi Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma
    K F Hsu
    Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taiwan, Republic of China
    Dis Esophagus 22:402-8. 2009
    Cortactin, fascin, and survivin have been documented in several human cancers and play important roles in tumor progression...
  23. doi Evaluation of survivin as a prognostic marker in oral squamous cell carcinoma
    Yong Hun Kim
    Department of Oral and Maxillofacial Surgery and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea
    J Oral Pathol Med 39:368-75. 2010
    ..We have evaluated survivin, which is a member of the inhibitor of apoptosis family as a cancer marker associated with proliferation, ..
  24. doi Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC)
    Yu Yang
    Department of Medical Oncology, Cancer Center of West China Hospital, Sichuan University, Chengdu, China
    Med Oncol 28:796-803. 2011
    Cox-2, Survivin and Bcl-2 are frequently overexpressed in numerous types of cancers. They are known to be the important regulators of apoptosis...
  25. doi Survivin as a predictive biomarker of complete pathologic response to neoadjuvant chemotherapy in patients with stage II and stage III breast cancer
    Cristiane Rios Petrarca
    Department of Oncology and Pathology, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre RS, Brazil
    Clin Breast Cancer 11:129-34. 2011
    ..Predictive biomarkers of response to neoadjuvant chemotherapy in patients with breast cancer are needed to better characterize tumors and enable more tailored therapies...
  26. pmc Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma
    Yu Hong Li
    State Key Laboratory of Oncology in Southern China, Guangzhou 510060, PR China
    J Transl Med 6:1. 2008
    ..The China 1992 TNM staging system has been widely used for prognosis prediction of NPC patients in China. Although NPC patients can be classified according to their clinical stage in this system, their prognosis may vary significantly...
  27. ncbi CD44v6, MMP-7 and nuclear Cdx2 are significant biomarkers for prediction of lymph node metastasis in primary gastric cancer
    Hirokazu Okayama
    Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Oncol Rep 22:745-55. 2009
    ..The aim of this study was to examine the expression of CD44v6, CD54, Cdx2, CXCL5, Cyclin B1, MMP-7, nm23, RCAS1 and Survivin in primary gastric cancer and to investigate whether these molecules were useful in predicting the lymph node ..
  28. ncbi Targeting survivin in cancer therapy: fulfilled promises and open questions
    Marzia Pennati
    Dipartimento di Oncologia Sperimentale, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, Italy
    Carcinogenesis 28:1133-9. 2007
    b>Survivin is a bifunctional protein that acts as a suppressor of apoptosis and plays a central role in cell division...
  29. ncbi [Correlation of -31G/C polymorphisms of survivin promoter to tumorigenesis of gastric carcinoma]
    Zheng Jiang Cheng
    Department of Clinical Laboratory Medicine, Xiangfan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Xiangfan, Hubei, 441021, P R China
    Ai Zheng 27:258-63. 2008
    b>Survivin, a bifunctional protein that regulates cell division and suppresses apoptosis, may play an important role in tumorigenesis...
  30. doi Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients
    Maria Lambropoulou
    Laboratory of Histology Embryology, Democritus University of Thrace, 68 100, Alexandroupolis, Greece
    J Cancer Res Clin Oncol 136:427-35. 2010
    The purpose of this study was to investigate the co-expression of survivin, c-erbB2, and COX-2 in endometrial cancer tissues and evaluate its prognostic significance in endometrial cancer
  31. ncbi A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells
    Yong Xu
    Section of Molecular and Cellular Biology, Department of Biological Sciences, University of Kentucky, Lexington 40536 0305, USA
    DNA Cell Biol 23:527-37. 2004
    b>Survivin, a unique antiapoptotic factor, plays an important role in cell cycle regulation...
  32. doi Gene expression of survivin and its spliced isoforms associated with proliferation and aggressive phenotypes of prostate cancer
    Hidekazu Koike
    Department of Urology, Gunma University Graduate School of Medicine, Maeabshi City, Gunma, Japan
    Urology 72:1229-33. 2008
    To assess the effect of survivin gene expression on the proliferation of prostate cancer (PCa) cells and study the association of suvivin and its spliced isoforms gene expression levels with the pathologic grade of PCa.
  33. pmc Increased survivin expression confers chemoresistance to tumor-associated endothelial cells
    Jenilyn J Virrey
    Departments of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Ave, HMR 315A, Los Angeles, CA 90033, USA
    Am J Pathol 173:575-85. 2008
    Growing evidence suggests that survivin, a member of the inhibitor of apoptosis gene family, is responsible for drug resistance in cancer cells, yet little is known about its role in the endothelial cells of the tumor vasculature...
  34. doi Survivin -31G/C promoter polymorphism and sporadic colorectal cancer
    Maria Gazouli
    Department of Biology, School of Medicine, University of Athens, Greece, 11725, Athens, Greece
    Int J Colorectal Dis 24:145-50. 2009
    b>Survivin is an apoptotic inhibitor, plays an important role in cell cycle regulation, and may be involved in the development and progression of cancer...
  35. pmc The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney
    Philipp Lechler
    Interdisciplinary Center for Clinical Research, Friedrich Alexander University Erlangen Nuremberg, Nuremberg, Germany
    Am J Pathol 171:1483-98. 2007
    The inhibitor of apoptosis protein survivin is of critical importance for regulation of cellular division and survival...
  36. pmc Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis
    Hugo Caldas
    Center for Childhood Cancer, Columbus Children s Research Institute, OH 43205, USA
    Blood 109:1479-89. 2007
    The identification of alternative splice variants of Survivin that possess distinct functions from those originally identified for the main Survivin isoform has greatly increased the complexity of our understanding of the role of Survivin ..
  37. ncbi Thrombospondin-1 (TSP-1) and Survivin (S) expression in non-Hogkin's lymphomas
    Semra Paydas
    Department of Oncology, Cukurova University Faculty of Medicine, Turkey
    Leuk Res 32:243-50. 2008
    b>Survivin (S) is a member of inhibitor of apoptosis family (IAP) and is expressed in the majority of malignant tumors but undetectable in normal differentiated adult tissues. S is an encouraging target for cancer therapy...
  38. doi Preoperative survivin mRNA detection in peripheral blood is an independent predictor of outcome in esophageal carcinoma
    Andreas Claudius Hoffmann
    Department of Medicine Cancer Research, Molecular Oncology Risk Profile Evaluation, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, Essen, 45147, Germany
    Pharmacogenomics 11:341-7. 2010
    b>Survivin (SVV) mRNA expression levels in peripheral blood of patients with gastrointestinal malignancies change significantly during the course of treatment...
  39. ncbi Cyclooxygenase-2 and survivin in superficial urothelial carcinoma of the bladder and correlation with intratumoural microvessel density
    U Yildirim
    Department of Pathology, Medical Faculty, Duzce University, Duzce, Turkey
    J Int Med Res 38:1689-99. 2010
    This study was designed to investigate the protein levels of cyclooxyogenase-2 (COX-2) and survivin in superficial urothelial carcinoma (UC) and their correlation with microvessel density (MVD)...
  40. ncbi INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis
    S P Wheatley
    Chromosome Structure Group, Institute of Cell and Molecular Biology, Swann Building, University of Edinburgh, King s Buildings, Mayfield Road, EH9 3JR, Edinburgh, United Kingdom
    Curr Biol 11:886-90. 2001
    Three lines of investigation have suggested that interactions between Survivin and the chromosomal passenger proteins INCENP and Aurora-B kinase may be important for mitotic progression...
  41. pmc Increased expression of survivin in gastric cancer patients and in first degree relatives
    J Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Br J Cancer 87:91-7. 2002
    b>Survivin was recently described as an apoptosis inhibitor. Its pathogenic role in gastric cancer is largely unknown...
  42. ncbi Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma
    F Piras
    Department of Cytomorphology, University of Cagliari, Cagliari, Italy
    Histopathology 50:835-42. 2007
    b>Survivin is expressed in neoplastic cells and appears to be associated with resistance to therapy and shorter survival in various types of tumours...
  43. ncbi Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer
    Hua Meng
    Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, Beijing, China
    Hepatogastroenterology 54:1934-40. 2007
    b>Survivin, a potential predictive marker to chemotherapeutic drugs, reduces the susceptibility of tumor cells to proapoptotic stimuli, thereby promoting tumor cell survival during tumor treatment with anticancer agents...
  44. doi Association between survivin gene promoter -31 C/G polymorphism and urothelial carcinoma risk in Taiwanese population
    Yuan Hung Wang
    Taipei Medical University School of Public Health, Taipei, Taiwan
    Urology 73:670-4. 2009
    To investigate the association between survivin gene promoter -31 C/G polymorphism and urothelial carcinoma (UC) risk in a Taiwanese population.
  45. ncbi Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
    A Suzuki
    Project for the Cell Death Research, Basic Technology Research Laboratory, Daiichi Pharmaceutical Co Ltd, Tokyo R and D Center, Kitakasai 1 16 13, Edogawa ku, Tokyo 134 8630, Japan
    Oncogene 19:1346-53. 2000
    ..b>Survivin is also a member of IAP family and is specifically expressed during embryogenesis and in tumor cells and ..
  46. ncbi Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis
    Yoshinori Kajiwara
    Department of Neurosurgery, Faculty of Medicine, Hiroshima University, Hiroshima, Japan
    Cancer 97:1077-83. 2003
    ..The mechanisms of genetic change of astrocytic tumors have not been understood completely. Recently, survivin has been identified as a member of the inhibitor-of-apoptosis family...
  47. pmc Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer
    B Ryan
    Department of Surgery, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland
    Br J Cancer 92:120-4. 2005
    Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3...
  48. ncbi Rational design of shepherdin, a novel anticancer agent
    Janet Plescia
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Cell 7:457-68. 2005
    ..on the binding interface between the molecular chaperone Hsp90 and the antiapoptotic and mitotic regulator, survivin. Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces ..
  49. ncbi Radiation-induced apoptosis of tumor cells is facilitated by inhibition of the interaction between Survivin and Smac/DIABLO
    Aki Ogura
    Laboratory of Radiation Biology, Department of Environmental Veterinary Medical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060 0818, Japan
    Cancer Lett 259:71-81. 2008
    To investigate the mechanism of radioresistance of solid tumor cells, we created two expression vectors encoding Survivin mutants, T34A and D53A...
  50. pmc Human survivin is a kinetochore-associated passenger protein
    D A Skoufias
    Institut de Biologie Structurale Jean Pierre Ebel Commissariat á l Energie Atomique Centre National de la Recherche Scientifique, 38027 Grenoble Cedex 1, France
    J Cell Biol 151:1575-82. 2000
    b>Survivin, a dimeric baculovirus inhibitor of apoptosis repeat (BIR) motif protein that is principally expressed in G2 and mitosis, has been associated with protection against apoptosis of cells that exit mitosis aberrantly...
  51. pmc Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma
    P Grabowski
    Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Benjamin Franklin Clinics, FU Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Br J Cancer 88:115-9. 2003
    b>Survivin, a new member of the family of apoptosis inhibitors, is expressed almost exclusively in proliferating cells, above all in cancers...
  52. pmc Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
    Susanne M A Lens
    Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 22:2934-47. 2003
    Genetic evidence is mounting that survivin plays a crucial role in mitosis, but its exact role in human cell division remains elusive...
  53. ncbi Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras
    Klaus W Sommer
    Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    Oncogene 22:4266-80. 2003
    Among the inhibitors of apoptosis proteins (IAPs), survivin has attracted special attention through its involvement in human cancer. The mechanism underlying tumour-associated survivin re-expression is not known...
  54. pmc Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade
    R A Altura
    Center for Cancer Research, Columbus Children s Research Institute, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA
    Br J Cancer 89:1743-9. 2003
    b>Survivin is a gene that is widely expressed throughout the development of the normal mammalian embryo...
  55. pmc Survivin expression in oral squamous cell carcinoma
    L Lo Muzio
    Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy
    Br J Cancer 89:2244-8. 2003
    ..carcinoma (SCC) together with six lymph node and one distant metastatic lesions was analysed for expression of survivin, a recent apoptosis inhibitor, by immunohistochemistry and Western blotting. In total, 91 cases (82...
  56. ncbi The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly
    Srinath C Sampath
    Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10021, USA
    Cell 118:187-202. 2004
    ..of Dasra A and Dasra B, two new components of the vertebrate chromosomal passenger complex containing Incenp, Survivin, and the kinase Aurora B, and demonstrate that this complex is required for chromatin-induced microtubule ..
  57. ncbi Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma
    Soichiro Morinaga
    Department of Surgery, Yokohama City Kowan Hospital, Nakaku, Yokohama 231 0801, Japan
    Oncol Rep 12:1189-94. 2004
    The clinical impact of survivin on human cancer pathogenesis and prognosis has been investigated...
  58. ncbi Ultraviolet-B radiation causes an upregulation of survivin in human keratinocytes and mouse skin
    Moammir Hasan Aziz
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Photochem Photobiol 80:602-8. 2004
    ..The cancer-specific expression of Survivin, a member of the inhibitor of apoptosis family of proteins, coupled with its importance in inhibiting cell death ..
  59. ncbi Survivin splice variants regulate the balance between proliferation and cell death
    Hugo Caldas
    Center for Childhood Cancer, Columbus Children s Research Institute, The Ohio State University, Columbus, OH, USA
    Oncogene 24:1994-2007. 2005
    b>Survivin is an inhibitor of apoptosis protein that also plays critical roles in regulating the cell cycle and mitosis...
  60. ncbi VEGF-mediated survivin expression in neuroblastoma cells
    Elizabeth A Beierle
    Department of Surgery, University of Florida, Gainesville, Florida 32610 0286, USA
    J Surg Res 127:21-8. 2005
    ..We hypothesize that VEGF will up-regulate survivin, a member of the IAP family of anti-apoptotic proteins, via the PI3K/Akt cell signaling pathway in human ..
  61. pmc Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC)
    Xiang Ling
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Lung Cancer 49:353-61. 2005
    Although it was observed that inhibition of the antiapoptotic protein survivin expression in lung cancer cells induces apoptosis, the expression and role of survivin variants (survivin-2B and survivin-DeltaEx3) in lung cancer have not yet ..
  62. ncbi Regulation of vein graft hyperplasia by survivin, an inhibitor of apoptosis protein
    Grace J Wang
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 25:2081-7. 2005
    b>Survivin (SVV) is an inhibitor of apoptosis protein (IAP) that is upregulated in cancer and has recently been implicated in vascular injury. We sought to investigate the role of SVV in vein graft hyperplasia.
  63. pmc Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody
    Gerben Vader
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    EMBO Rep 7:85-92. 2006
    ..through the mitotic cell by its companion chromosomal passenger proteins, inner centromere protein (INCENP), Survivin and Borealin/Dasra-B, thereby allowing it to act at the right place at the right time...
  64. ncbi Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis
    Elizabeth A Noton
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    J Biol Chem 281:1286-95. 2006
    b>Survivin is a protein with proposed roles in cell division and apoptosis. Transcripts encoding splice variants of human survivin have been described and their expression correlated with cancer progression...
  65. pmc Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP
    Ulf R Klein
    Department of Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Mol Biol Cell 17:2547-58. 2006
    ..passenger complex (CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome alignment and ..
  66. ncbi Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis
    Alessandra Marconi
    Department of Medicine, Institute of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    Stem Cells 25:149-55. 2007
    b>Survivin belongs to the family of inhibitor of apoptosis proteins and is involved in regulation of cell death as well as cell division...
  67. pmc The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function
    Shirley K Knauer
    Georg Speyer Haus, Paul Ehrlich Strasse 42 44, Frankfurt D 60596, Germany
    EMBO Rep 7:1259-65. 2006
    The chromosomal passenger complex (CPC) of Aurora-B, Borealin, INCENP (inner centromere protein) and Survivin coordinates essential chromosomal and cytoskeletal events during mitosis...
  68. doi The prognostic significance of COX-2 and survivin expression in ovarian cancer
    Pauline Athanassiadou
    Pathology Laboratory, Cytology Department, Medical School, Athens University, 75 Mikras Asias Street, 11527 Athens, Greece
    Pathol Res Pract 204:241-9. 2008
    We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma...
  69. pmc Expression of survivin protein in pterygium and relationship with oxidative DNA damage
    C Maxia
    Department of Cytomorphology, University of Cagliari Medical School, Cagliari, Italy
    J Cell Mol Med 12:2372-80. 2008
    ..This assumption is supported by the association between UV-B exposure and activation of survivin, a member of the inhibitor of apoptosis protein family (IAP), highly up-regulated in almost all types of human ..
  70. ncbi Silencing survivin results in synergy between methylseleninic acid and paclitaxel against skov3 ovarian cancer cells
    Rami G Azrak
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 7:1901-8. 2008
    ..acid (MSeA) improvement of paclitaxel efficacy against human ovarian cancer (skov3) with regard to survivin expression. MSeA and paclitaxel alone and in concurrent or sequential combination treatments were tested...
  71. ncbi An IAP-IAP complex inhibits apoptosis
    Takehiko Dohi
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 279:34087-90. 2004
    ..Here, we show that in response to cell death stimulation, survivin, a member of the inhibitor of apoptosis (IAP) gene family, associates with another IAP protein, XIAP, via ..
  72. ncbi Separating the anti-apoptotic and mitotic roles of survivin
    Rita Colnaghi
    Genome Damage and Stability Centre, Department of Life Sciences, University of Sussex, Falmer, Brighton BN1 9RQ, UK
    J Biol Chem 281:33450-6. 2006
    b>Survivin is a bifunctional protein that acts as a suppressor of apoptosis and has an essential role in mitosis. To date whether these two functions can be divorced has not been addressed...
  73. ncbi Changes of survivin mRNA and protein expression during paclitaxel treatment in breast cancer cells
    Huihua Xiong
    Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:65-7. 2007
    In order to investigate the role of antiapoptosis gene, survivin in the resistance to palcitaxel, the expression of survivin mRNA and protein in the process of paclitaxel treatment in breast cancer cell line MCF-7 was detected MCF-7 cells ..
  74. ncbi Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9110, USA
    Urology 70:482-6. 2007
    b>Survivin is a member of the inhibitor of apoptosis gene family that controls mitotic progression and induces tumor cell invasion...
  75. doi Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
    Donal J Brennan
    UCD School of Biomolecular and Biomedical Science and UCD School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Clin Cancer Res 14:2681-9. 2008
    b>Survivin (BIRC5) is a promising tumor biomarker. Conflicting data exist on its prognostic effect in breast cancer...
  76. doi Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis
    Claire M Connell
    Centre for Molecular Oncology and Imaging, Institute of Cancer, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Cancer Res 68:7923-31. 2008
    b>Survivin (BIRC5) promotes cell division and survival with roles as chromosomal passenger protein and inhibitor of apoptosis protein (IAP). It is overexpressed in many cancers and is associated with resistance to chemotherapy and radiation...
  77. doi Increased extracellular survivin in the synovial fluid of rheumatoid arthritis patients: fibroblast-like synoviocytes as a potential source of extracellular survivin
    Joong Kyong Ahn
    Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Inflammation 33:381-8. 2010
    b>Survivin belongs to the family of inhibitor of apoptosis proteins and plays an important role in the hyperplastic growth of tissues and tumors...
  78. pmc Survivin is released from cancer cells via exosomes
    Salma Khan
    Center for Health Disparities Research and Molecular Medicine, Loma Linda University, 11085 Campus Street, Loma Linda, CA 92350, USA
    Apoptosis 16:1-12. 2011
    ..The IAP Survivin has been implicated in apoptosis inhibition and the regulation of mitosis in cancer cells...
  79. doi The survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival
    Anna G Antonacopoulou
    Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
    Cell Oncol (Dordr) 34:381-91. 2011
    b>Survivin is involved in the regulation of cell division and survival, two key processes in cancer...
  80. ncbi Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting
    G Ambrosini
    Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 273:11177-82. 1998
    b>Survivin is a new IAP apoptosis inhibitor expressed during development and in human cancer in vivo...
  81. pmc Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
    D S O'Connor
    Departments of Pathology, Dermatology, and Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 97:13103-7. 2000
    ..Here, we show that survivin, an inhibitor of apoptosis over-expressed in cancer, physically associates with the cyclin-dependent kinase p34(..
  82. ncbi Quantitatively determined survivin expression levels are of prognostic value in human gliomas
    Arnab Chakravarti
    Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA
    J Clin Oncol 20:1063-8. 2002
    b>Survivin is a novel antiapoptotic gene that has been recently cloned and characterized. Its expression has been found to be of prognostic significance in several tumor types...
  83. ncbi CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin
    Jose A Rodriguez
    Department of Medical Oncology, VU University Medical Center, Amsterdam, HV1081, The Netherlands
    Exp Cell Res 275:44-53. 2002
    b>Survivin is a member of the inhibitor of apoptosis (IAP) family of negative regulators of programmed cell death that is frequently overexpressed in human tumors...
  84. ncbi Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer
    N Zaffaroni
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cell Mol Life Sci 59:1406-12. 2002
    Stable transfection of human ovarian carcinoma cells with survivin cDNA caused a four- to sixfold increase in cell resistance to taxotere and taxol (two-sided Student's t test, p < 0...
  85. ncbi Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis
    Nathan R Wall
    Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 63:230-5. 2003
    b>Survivin is a member of the inhibitor of apoptosis gene family that is expressed in most human cancers and may facilitate evasion from apoptosis and aberrant mitotic progression...
  86. ncbi Expression of survivin and caspase-3 in gastric cancer
    J Kania
    Department of Internal Medicine, University Erlangen Nuremberg, Erlangen, Germany
    Dig Dis Sci 48:266-71. 2003
    ..Caspase-3 and survivin are regulators of apoptosis and have been implicated in the development of gastric cancer...
  87. ncbi Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis
    Zhiyin Song
    Department of Molecular and Cell Biology, Key Laboratory of Structural Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People s Republic of China
    J Biol Chem 278:23130-40. 2003
    b>Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and cell cycle control. However, its inhibitory mechanism and subcellular localization remain controversial...
  88. ncbi Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence
    I J Schultz
    Department of Clinical Chemistry 564, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Anticancer Res 23:3327-31. 2003
    Expression of the inhibitor of apoptosis protein survivin is up-regulated in many tumors of epithelial origin and frequently shows a relationship with disease prognosis.
  89. ncbi Survivin expression in hepatocellular carcinoma: correlation with proliferation, prognostic parameters, and outcome
    Angela C Fields
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mod Pathol 17:1378-85. 2004
    b>Survivin is a novel inhibitor of apoptosis. It is detected in fetal and neoplastic adult tissue, but not in normal tissues...
  90. pmc Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome
    J R Fangusaro
    Center for Childhood Cancer Research, Columbus Children s Research Institute CCRI, College of Medicine and Public Health, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Br J Cancer 92:359-65. 2005
    b>Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies...
  91. ncbi Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein
    Byoung Heon Kang
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 281:24721-7. 2006
    b>Survivin is a multifunctional member of the IAP (inhibitor of apoptosis) family, but its molecular interactions in protection from cell death and regulation of cell division have not been completely elucidated...
  92. ncbi Nuclear localization of Survivin renders HeLa tumor cells more sensitive to apoptosis by induction of p53 and Bax
    Achim Temme
    Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cancer Lett 250:177-93. 2007
    Clinical studies have shown that nuclear expression of the inhibitor of apoptosis protein Survivin in tumor cells predicted a favorable prognosis whereas cytosolic-localized protein caused a decreased overall survival...
  93. ncbi Survivin's dual role: an export's view
    Shirley K Knauer
    Department of Otorhinolaryngology, Molecular and Cellular Oncology, University of Mainz, Mainz, Germany
    Cell Cycle 6:518-21. 2007
    b>Survivin is proposed to function as a mitotic regulator and an apoptosis inhibitor during development and pathogenesis. As such, survivin has aroused keen interest in disparate areas of basic and translational research...
  94. ncbi Survivin expression in non-small-cell lung carcinomas: correlation with apoptosis and other apoptosis-related proteins, clinicopathologic prognostic factors and prognosis
    Emine Cagnur Ulukus
    Department of Pathology, Dokuz Eylul University School of Medicine, 35340 Inciralti, Izmir, Turkey
    Appl Immunohistochem Mol Morphol 15:31-7. 2007
    The role of survivin that regulates the biological behavior of non-small-cell lung carcinoma (NSCLC) is still controversial...
  95. ncbi Clinicopathological significance of survivin expression in patients with hepatocellular carcinoma
    G Y Chau
    Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    Histopathology 51:204-18. 2007
    b>Survivin, a newly discovered member of the inhibitor of apoptosis protein family, is suggested to be involved in liver carcinogenesis...
  96. ncbi Polymorphisms in the survivin gene and the risk of lung cancer
    Jin Sung Jang
    Cancer Research Institute, Kyungpook National University School of Medicine, Daegu 700 422, Republic of Korea
    Lung Cancer 60:31-9. 2008
    b>Survivin is an apoptosis inhibitor and plays an important role in the development and progression of cancer...
  97. ncbi Survivin: a promising biomarker for detection and prognosis of bladder cancer
    Vitaly Margulis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    World J Urol 26:59-65. 2008
    b>Survivin is a 16.5 kDa member of the inhibitor of apoptosis protein family that is overexpressed in many malignancies but rarely detected in normal differentiated adult tissues...
  98. doi NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas
    Knut Engels
    Department of Pathology, University Hospital of Frankfurt, Frankfurt, Germany
    Cancer Res 68:5159-66. 2008
    ..The dual role of survivin as an apoptosis inhibitor and mitotic regulator has been associated with disease outcome...
  99. pmc Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis
    Connie W Lee
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 68:5273-81. 2008
    ..cancer cells results in direct transcriptional up-regulation of the apoptosis inhibitor and cell cycle regulator survivin. This response is associated with increased expression of survivin at mitosis, enhanced cell proliferation, and ..
  100. doi Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells
    Ryosuke Moriai
    Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Breast Cancer Res Treat 117:261-71. 2009
    ..Overexpression of the anti-apoptotic molecule survivin rendered the human breast cancer cells MCF-7 resistant to tamoxifen-induced apoptosis...
  101. ncbi Functional significance of a putative sp1 transcription factor binding site in the survivin gene promoter
    M V Mityaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 73:1183-91. 2008
    We sequenced 1500-bp genomic DNA regions upstream from the survivin gene (BIRC5). DNA was isolated from human placenta and tumors of patients with diagnosed squamous cancer of the lung that showed high-level BIRC5 gene expression...

Research Grants18

  1. MOLECULAR INTERACTIONS OF BLOOD COAGULATION FACTOR XA
    Katherine High; Fiscal Year: 1999
    ..This work will contribute to our understanding of the molecular interactions by which F.Xa exerts its biological effects in enzyme complexes and through cellular receptors. ..
  2. INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSION
    Arnab Chakravarti; Fiscal Year: 2003
    ..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
  3. High Throughput Screening Assays for NOD1 and NOD2 Inhibitors
    John Reed; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Mitochondria and Apoptosis (revised GM60554)
    John Reed; Fiscal Year: 2009
    ..abstract_text> ..
  5. Mechanisms of the HBX-interacting protein (HBXIP)
    John Reed; Fiscal Year: 2008
    ..Recently, we demonstrated that HBXIP interacts with Survivin, a protein over-expressed in most human cancers that regulates both cell division and apoptosis...
  6. Chemical Antagonists of IAP-Family Anti-Apoptotic Proteins
    John Reed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. Molecular Targeting of the Survivin Pathway in Cancer
    Dario C Altieri; Fiscal Year: 2010
    b>Survivin is a member of the Inhibitor of Apoptosis (IAP) gene family that has attracted attention for its dual role in cell division and cytoprotection, and its overexpression in nearly every human tumor...
  8. HTS Assay for UBC13, a Mediator of Inflammatory Signaling
    John Reed; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Chemical Inhibitors of ER Stress
    John Reed; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. CED-4 FAMILY PROTEINS
    John Reed; Fiscal Year: 2003
    ..The information provided by these investigations may provide insights into human diseases where dysregulation of programmed cell death is known to occur and may lead to new strategies for therapeutic intervention. ..
  11. BI-1, A Regulator of ER-Stress Pathways Linked to Apoptosis
    John Reed; Fiscal Year: 2009
    ..Altogether, these studies will improve understanding of how damage to the ER is linked to apoptosis, and will potentially reveal strategies for neuronal preservation in stroke and neurodegenerative diseases. ..
  12. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  13. Proteomic analysis of head & neck squamous cell cancer
    Michael Prystowsky; Fiscal Year: 2005
    ....
  14. Discovery and characterization of breast cancer genes
    John Hodgson; Fiscal Year: 2008
    ..Finally, effects on in vivo tumorigenic potential will be assessed by evaluating tumor growth in immunedeficient mice. [unreadable] [unreadable]..
  15. MUTUAL REGULATION OF P53, MDM2 AND NFKB:
    Muxiang Zhou; Fiscal Year: 2004
    ....
  16. MECHANISM OF INDUCTION OF MALIGNANT GLIOMAS
    Demetrius Kokkinakis; Fiscal Year: 2002
    ..Genetic differences between tumor cells and those capable of infiltrating the normal parenchyma will also be identified and compared to those of initiated multipotent progenitor cells in order to understand their lineage. ..
  17. A1 REGULATED LEUKOCYTE APOPTOSIS DURING INFLAMMATION
    Michael Prystowsky; Fiscal Year: 2001
    ..3) Protection of macrophages during inflammation is mediated by A1 and is vital for host defense. ..