SUN1

Summary

Gene Symbol: SUN1
Description: Sad1 and UNC84 domain containing 1
Alias: UNC84A, SUN domain-containing protein 1, Sad1 unc-84 domain protein 1, protein unc-84 homolog A, sad1/unc-84 protein-like 1, unc-84 homolog A
Species: human

Top Publications

  1. ncbi UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development
    C J Malone
    Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder CO 80309 0347, USA
    Development 126:3171-81. 1999
  2. pmc Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle
    E Mattioli
    Institute for Molecular Genetics, IGM CNR, Unit of Bologna, Bologna, Italy
    Cell Death Differ 18:1305-15. 2011
  3. pmc Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies
    Chia Yen Chen
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
    Cell 149:565-77. 2012
  4. pmc LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins
    Brian A Sosa
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell 149:1035-47. 2012
  5. doi Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies
    Zi Jie Chen
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
    J Cell Sci 127:1792-804. 2014
  6. pmc Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development
    K Natalie Randles
    Wolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Oswestry, United Kingdom
    Dev Dyn 239:998-1009. 2010
  7. pmc Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
    Farhana Haque
    Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 285:3487-98. 2010
  8. pmc Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness
    P J Stewart-Hutchinson
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 314:1892-905. 2008
  9. pmc Functional association of Sun1 with nuclear pore complexes
    Qian Liu
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Biol 178:785-98. 2007
  10. ncbi Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Biol Chem 282:27447-58. 2007

Research Grants

  1. Ju Chen; Fiscal Year: 2015
  2. Lamin A in Adipocyte Differentation and Survival
    Howard Worman; Fiscal Year: 2004
  3. DUX4 and Facioscapulohumeral Muscular Dystrophy
    Howard Worman; Fiscal Year: 2004
  4. Lamin A Mutation and Hutchinson-Gilford Progeria
    Howard Worman; Fiscal Year: 2008
  5. NUCLEAR DIFFERENTATION DURING MURINE GRANULOPOIESIS
    DONALD OLINS; Fiscal Year: 2004

Scientific Experts

  • Howard Worman
  • Ya Hui Chi
  • Baohua Liu
  • Harry Scherthan
  • Qiang Wang
  • Donald E Olins
  • Manfred Alsheimer
  • Didier Hodzic
  • Rener Xu
  • Kai Lei
  • Hiroki Shibuya
  • Min Han
  • Colin L Stewart
  • Peter Meinke
  • Sue Shackleton
  • Ricardo Benavente
  • Brian Burke
  • Ju Chen
  • Tian Xu
  • Yuan Zhuang
  • Farhana Haque
  • Yoshinori Watanabe
  • Kuan Teh Jeang
  • Henning F Horn
  • Irene Meyer
  • Ralph Gräf
  • Eva Göb
  • Angelika A Noegel
  • Jing Ya Wang
  • Alberto Viera
  • Iakowos Karakesisoglou
  • Chia Yen Chen
  • Jennifer T Patel
  • Akihiro Morimoto
  • Santhosh Gudise
  • Manfred Wehnert
  • Oliver Kuhnert
  • Kyle J Roux
  • Juehua Yu
  • P J Stewart-Hutchinson
  • Xiaochang Zhang
  • Xu Ding
  • Ayaka Matsumoto
  • Petros Batsios
  • Petra Mikolcevic
  • José A Suja
  • Wenshu Lu
  • Francisca Lottersberger
  • Javier Varas
  • Xiao Zhou
  • Alexandre Chaumet
  • Qian Liu
  • Melissa Crisp
  • Wan Ping Wang
  • WenJing Liu
  • Katrin Daniel
  • Weipeng Mu
  • Roberto de la Fuente
  • Jana Link
  • Graham D Wright
  • Mohammed Hakim Jafferali
  • Zi Jie Chen
  • Edward H Davidson
  • Giovanna Lattanzi
  • David S Razafsky
  • Marta Columbaro
  • Kingsley A Boateng
  • Einar Hallberg
  • Ricardo A Figueroa
  • Surayya Taranum
  • Brian A Sosa
  • Yousin Suh
  • Daria Camozzi
  • David Razafsky
  • Xiaoqiang Zhu
  • Laure Crabbe
  • Lee Wallace
  • Gregg G Gundersen
  • E Mattioli
  • Cornelia Frohnert
  • Xian zhen Jiang
  • Jessica A Talamas
  • Michael T Jungwirth
  • Erin C Tapley
  • Otto Baumann
  • Daniel Jahn
  • K Natalie Randles
  • Andrew M Fry
  • Lixin Zhou
  • Cecilia Ostlund

Detail Information

Publications83

  1. ncbi UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development
    C J Malone
    Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder CO 80309 0347, USA
    Development 126:3171-81. 1999
    ..We propose that UNC-84 functions to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage...
  2. pmc Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle
    E Mattioli
    Institute for Molecular Genetics, IGM CNR, Unit of Bologna, Bologna, Italy
    Cell Death Differ 18:1305-15. 2011
    ..Among the nuclear envelope partners of lamin A are Sad1 and UNC84 domain-containing protein 1 (SUN1) and Sad1 and UNC84 domain-containing protein 2 (SUN2), which mediate nucleo-cytoskeleton interactions critical to ..
  3. pmc Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies
    Chia Yen Chen
    National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA
    Cell 149:565-77. 2012
    ..Unexpectedly, Lmna(-/-) or LmnaΔ9 mice that are also deficient for the inner nuclear membrane protein Sun1 show markedly reduced tissue pathologies and enhanced longevity...
  4. pmc LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins
    Brian A Sosa
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cell 149:1035-47. 2012
    ..The structure provides the basis of LINC complex formation and suggests a model for how LINC complexes might arrange into higher-order clusters to enhance force-coupling...
  5. doi Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies
    Zi Jie Chen
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
    J Cell Sci 127:1792-804. 2014
    ..We reported previously that the accumulation of the nuclear envelope protein SUN1 contributes to HGPS nuclear aberrancies...
  6. pmc Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development
    K Natalie Randles
    Wolfson Centre for Inherited Neuromuscular Disease, RJAH Orthopaedic Hospital, Oswestry, United Kingdom
    Dev Dyn 239:998-1009. 2010
    ..b>Sun1 and Sun2 proteins remained unchanged during this fibre maturation...
  7. pmc Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes
    Farhana Haque
    Department of Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Biol Chem 285:3487-98. 2010
    ..b>SUN1 and SUN2 interact with lamin A, but lamin A is only required for NE localization of SUN2, and it remains unclear ..
  8. pmc Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness
    P J Stewart-Hutchinson
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Cell Res 314:1892-905. 2008
    ..Here, we show that the KASH domains of Nesprins 1, 2 and 3 interact promiscuously with luminal domains of Sun1 and Sun2...
  9. pmc Functional association of Sun1 with nuclear pore complexes
    Qian Liu
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    J Cell Biol 178:785-98. 2007
    b>Sun1 and 2 are A-type lamin-binding proteins that, in association with nesprins, form a link between the inner nuclear membranes (INMs) and outer nuclear membranes of mammalian nuclear envelopes...
  10. ncbi Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Biol Chem 282:27447-58. 2007
    ..We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis...
  11. ncbi Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 25:554-62. 2006
    ..We found that a structurally related protein, SUN1, may be localized to the nuclear envelope through a different mechanism...
  12. pmc Coupling of the nucleus and cytoplasm: role of the LINC complex
    Melissa Crisp
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610
    J Cell Biol 172:41-53. 2006
    ..The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2...
  13. ncbi The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope
    V C Padmakumar
    Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    J Cell Sci 118:3419-30. 2005
    ..a direct association of their highly conserved C-terminal luminal domain with the inner nuclear membrane protein Sun1 mediates their nuclear envelope localisation...
  14. ncbi Nuclear membrane proteins with potential disease links found by subtractive proteomics
    Eric C Schirmer
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 301:1380-2. 2003
    ..Furthermore, 23 of these mapped within chromosome regions linked to a variety of dystrophies...
  15. ncbi Nuclear envelope localization of human UNC84A does not require nuclear lamins
    Sameez Hasan
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    FEBS Lett 580:1263-8. 2006
    The SUN proteins are a conserved family of proteins in eukaryotes. Human UNC84A (Sun1) is a homolog of Caenorhabditis elegans UNC-84, a protein involved in nuclear anchorage and migration...
  16. doi MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells
    Mohammed Hakim Jafferali
    Department of Neurochemistry, Stockholm University, SE10691 Stockholm, Sweden
    Biochim Biophys Acta 1838:2399-403. 2014
    ..protein Samp1 interacts with Lamin B1, the LINC (Linker of nucleoskeleton and cytoskeleton) complex protein, Sun1 and the soluble small GTPase Ran...
  17. pmc Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
    Petra Mikolcevic
    Institute for Research in Biomedicine IRB Barcelona, Barcelona Institute of Science and Technology, Barcelona 08028, Spain
    Nat Commun 7:11084. 2016
    ..and RingoA KO spermatocytes display severely affected telomere tethering as well as impaired distribution of Sun1, a protein essential for the attachment of telomeres to the nuclear envelope...
  18. pmc Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli
    Ayaka Matsumoto
    a Osaka University, Graduate School of Medicine and Health Science, Suita City, Osaka, Japan
    Nucleus 7:68-83. 2016
    ..We found that a reduction in the levels of SUN1, SUN2, and lamin A/C led to significant changes in morphologies that were computationally classified using wndchrm ..
  19. doi Proximity-Dependent Biotin Identification (BioID) in Dictyostelium Amoebae
    Petros Batsios
    Institute for Biochemistry and Biology, Department of Cell Biology, University of Potsdam, Potsdam, Germany
    Methods Enzymol 569:23-42. 2016
    ..We adapted the BioID method for use in Dictyostelium amoebae. The protocols described here successfully revealed Dictyostelium lamin-like protein NE81 proximity to Sun1, a conserved inner nuclear membrane protein.
  20. pmc 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair
    Francisca Lottersberger
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 163:880-93. 2015
    ..We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nucleoskeleton, and cytoskeleton (LINC) complex and dynamic microtubules...
  21. pmc Nuclear envelope-associated endosomes deliver surface proteins to the nucleus
    Alexandre Chaumet
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
    Nat Commun 6:8218. 2015
    ..RNAi screening further revealed that NAE-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex...
  22. pmc Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function
    Jana Link
    Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Wurzburg, Germany
    PLoS Genet 10:e1004099. 2014
    ..In mice, SUN1 and SUN2 are the only SUN domain proteins expressed during meiosis, sharing their localization with meiosis-..
  23. pmc The missing LINC: a mammalian KASH-domain protein coupling meiotic chromosomes to the cytoskeleton
    Colin L Stewart
    Institute of Medical Biology Immunos Singapore
    Nucleus 5:3-10. 2014
    ..Recent studies reveal that coupling of telomeres to cytoplasmic dynein is mediated by SUN1 in the inner nuclear membrane (INM) and KASH5 a novel protein of the outer nuclear membrane (ONM)...
  24. doi Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
    WenJing Liu
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China College of Life Science and Technology, Southwest University of Science and Technology, Mianyang, Sichuan 621000, China
    Dev Biol 392:108-16. 2014
    ..Here, we show that CDK2, especially p39(cdk2), as a potential meiosis-specific connector interaction with SUN1 mediates formation of telomere clustering during mouse meiosis...
  25. pmc Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein
    Katrin Daniel
    Institute of Physiological Chemistry, Technische Universitat Dresden, Fiedlerstr, 42, Dresden 01307, Germany
    BMC Cell Biol 15:17. 2014
    ..Although inner-nuclear envelope proteins, such as SUN1 and potentially SUN2, are known to bind and recruit meiotic telomeres, these proteins are not meiosis-specific, ..
  26. pmc Chromatin organization and remodeling of interstitial telomeric sites during meiosis in the Mongolian gerbil (Meriones unguiculatus)
    Roberto de la Fuente
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Genetics 197:1137-51. 2014
    ..some centromeric regions of metacentric chromosomes may bind the nuclear envelope through the association to SUN1 protein, a feature usually performed by telomeres...
  27. pmc Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization
    Peter Meinke
    Institute of Human Genetics and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany
    PLoS Genet 10:e1004605. 2014
    ..Using a candidate approach, we have identified putative disease-causing variants in the SUN1 and SUN2 genes, also encoding LINC complex components, in patients with EDMD and related myopathies...
  28. pmc Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
    Weipeng Mu
    Department of Genetics, Carolina Center for Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA
    Genes Dev 28:2056-69. 2014
    ..Moreover, mutant spermatocytes exhibited ectopic expression of somatic lamins and an abnormal distribution of SUN1 proteins on the nuclear envelope...
  29. doi CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase
    Alberto Viera
    Unidad de Biologia Celular, Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, E 28049 Madrid, Spain
    J Cell Sci 128:88-99. 2015
    ..that the ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome...
  30. pmc Sun1 deficiency leads to cerebellar ataxia in mice
    Jing Ya Wang
    Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
    Dis Model Mech 8:957-67. 2015
    ..Here, we report an unrecognized contribution of Sun1 and Sun2 to the postnatal development of murine cerebellum...
  31. doi Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination
    Javier Varas
    Departamento de Genetica, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, 28040, Spain
    Plant J 81:329-46. 2015
    ..We propose that in Arabidopsis thaliana, overlapping functions of SUN1 and SUN2 ensure normal meiotic recombination and synapsis.
  32. pmc Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1
    Xiao Zhou
    a Department of Molecular Genetics The Ohio State University Columbus, OH USA
    Nucleus 6:144-53. 2015
    ..Recently, an interaction between Arabidopsis SUN1 and SUN2 proteins and CRWN1, a plant analog of lamins, has been reported...
  33. pmc Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact
    Jennifer T Patel
    a Department of Biochemistry University of Leicester Leicester, UK
    Nucleus 5:462-73. 2014
    ..Here, we show that SUN1, located in the INM, undergoes mitosis-specific phosphorylation on at least 3 sites within its nucleoplasmic N-..
  34. pmc The dissection of meiotic chromosome movement in mice using an in vivo electroporation technique
    Hiroki Shibuya
    Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    PLoS Genet 10:e1004821. 2014
    ..from leptotene/zygotene to pachytene, and then decline in diplotene stage concomitant with the liberation of SUN1 from telomeres...
  35. ncbi Dialing down SUN1 for laminopathies
    Yousin Suh
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 149:509-10. 2012
    ..In this issue, Chen et al. provide evidence that elevated expression of the nuclear inner membrane protein SUN1 drives pathology in multiple laminopathies.
  36. pmc Nucleocytoplasmic connections and deafness
    Howard J Worman
    Department of Medicine, College of Physician and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    J Clin Invest 123:553-5. 2013
    ..Further, in mice deficient in nesprin-4 and Sun1, another LINC complex component, outer hair cells of the cochlea form normally during development, but die in the ..
  37. pmc Homologous pairing preceding SPO11-mediated double-strand breaks in mice
    Kingsley A Boateng
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 24:196-205. 2013
    ..Intriguingly, SUN1, a protein required for telomere attachment to the nuclear envelope and for post-DSB synapsis, is also required for ..
  38. pmc Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly
    Laure Crabbe
    Molecular and Cellular Biology Department, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Rep 2:1521-9. 2012
    ..envelope, most likely via specific interactions between the shelterin subunit RAP1 and the nuclear envelope protein Sun1. Genetic interference revealed a critical role in cell-cycle progression for Sun1 but no effect on telomere ..
  39. pmc LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina
    David Razafsky
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    PLoS ONE 7:e47180. 2012
    ..We further show that Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, ..
  40. pmc Reversal of laminopathies: the curious case of SUN1
    Ya Hui Chi
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
    Nucleus 3:418-21. 2012
    ..We recently found that the accumulation of the inner nuclear envelope proteins SUN1 is pathogenic in progeric and dystrophic laminopathies...
  41. pmc Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response
    Kai Lei
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Curr Biol 22:1609-15. 2012
    ..Recent findings indicate that accumulation of SUN1, a nuclear envelope (NE) protein, is a significant pathogenic event in Emery-Dreifuss muscular dystrophy and ..
  42. pmc A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis
    Akihiro Morimoto
    Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Cell Biol 198:165-72. 2012
    ..However, although the vertebrate SUN domain protein SUN1 is involved in these processes, its partner has remained identified...
  43. pmc From loss to gain: role for SUN1 in laminopathies
    Baohua Liu
    Department of Biochemistry, The University of Hong Kong, 3 F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong
    Cell Biosci 2:21. 2012
    ..A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function ..
  44. pmc Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment
    Daria Camozzi
    Institute of Molecular Genetics, Unit of Bologna IOR, National Research Council of Italy CNR, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Histochem Cell Biol 138:643-51. 2012
    ..Given the major role of SUN1 and SUN2 in the nucleo-cytoskeleton interactions and in regulation of nuclear positioning in differentiating cells, ..
  45. pmc LINC complex alterations in DMD and EDMD/CMT fibroblasts
    Surayya Taranum
    Institute for Biochemistry I, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, 50931 Cologne, Germany
    Eur J Cell Biol 91:614-28. 2012
    ..EDMD/CMT) that in addition to the disease causing mutations harbour mutations in the Nesprin-1 gene and in the SUN1 and SUN2 gene, respectively...
  46. pmc Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis
    David S Razafsky
    Department of Ophthalmology and Visual Sciences Washington University School of Medicine St Louis, MO USA Division of Molecular Genetics German Cancer Research Center DKFZ Heidelberg, Germany
    Nucleus 4:399-409. 2013
    ..Whereas retinal precursor cells mostly express B-type lamins, Sun1, and high molecular weight isoforms of Nesprins, post-mitotic retinal cells are characterized by a drastic ..
  47. doi Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity
    Lee Wallace
    Institute of Cellular Medicine and North East England Stem Cell Institute, Newcastle University, Newcastle upon Tyne, UK
    J Cell Sci 125:1750-8. 2012
    ..mice showed premature loss of nuclei during epidermal differentiation and lower levels of emerin, lamin A/C and Sun1, revealing a previously unknown function for IFs in maintaining nuclear integrity in the upper epidermis.
  48. doi Functional characterization of CP148, a novel key component for centrosome integrity in Dictyostelium
    Oliver Kuhnert
    Department of Cell Biology, Institute for Biochemistry and Biology, University of Potsdam, Karl Liebknecht Strasse 24 25, Haus 26, 14476, Potsdam Golm, Germany
    Cell Mol Life Sci 69:1875-88. 2012
    ..Furthermore, CP148 RNAi caused dispersal of centromeres and altered Sun1 distribution at the nuclear envelope, suggesting a role of CP148 in the linkage between centrosomes and centromeres...
  49. pmc A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton
    Henning F Horn
    Laborotory of Nuclear Dynamics and Architecture, 2 Laboratory of Developmental and Regenerative Biology, and 3 IMB Microscopy Unit, Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore 138648
    J Cell Biol 202:1023-39. 2013
    ..In metazoans, telomere clustering is dynein and microtubule dependent and requires Sun1, an inner nuclear membrane protein...
  50. ncbi EDS1 in tomato is required for resistance mediated by TIR-class R genes and the receptor-like R gene Ve
    Gongshe Hu
    USDA, Plant Gene Expression Center, 800 Buchanan St, Albany, CA 94710, USA
    Plant J 42:376-91. 2005
    ..Here, we report the use of N-transgenic tomato to identify a fast-neutron mutant, sun1-1 (suppressor of N), that is defective in N-mediated resistance...
  51. ncbi Sun2 is a novel mammalian inner nuclear membrane protein
    Didier M Hodzic
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:25805-12. 2004
    Sun protein (Sun1 and Sun2) cDNAs were previously cloned based on the homology of their C-terminal regions (SUN (Sad1 and UNC) domain) with the Caenorhabditis elegans protein UNC-84 whose mutation disrupts nuclear migration/positioning...
  52. ncbi Mad1p, a component of the spindle assembly checkpoint in fission yeast, suppresses a novel septation-defective mutant, sun1, in a cell-division cycle
    In G Kim
    Department of Molecular Biology, Graduate School of Biotechnology, Korea University, 136 701, Seoul, South Korea
    FEMS Microbiol Lett 227:183-8. 2003
    ..Here we present the isolation and characterization of a new temperature-sensitive mutant, sun1 (septum uncontrolled), which undergoes uncontrolled septation during cell-division cycle at restrictive temperature ..
  53. pmc The LINC complex is essential for hearing
    Henning F Horn
    Institute of Medical Biology, A STAR, Singapore
    J Clin Invest 123:740-50. 2013
    ..NESP4 and SUN domain-containing protein 1 (SUN1), which localizes to the inner nuclear membrane (INM), are part of the linker of nucleoskeleton and cytoskeleton (..
  54. doi Lacunocanalicular fluid flow transduces mechanical tension stress during distraction osteogenesis
    Edward H Davidson
    From the Department of Plastic Surgery, New York University Langone Medical Center, New York, New York
    J Craniofac Surg 24:1558-64. 2013
    ..Protein was harvested for focal adhesion kinase 1 (FAK1), NESPRIN1, SUN1, LAMIN A/C, and SMAD1 Western blotting as well as for bone morphogenetic protein (BMP)-2 enzyme-linked ..
  55. pmc SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice
    Kai Lei
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Proc Natl Acad Sci U S A 106:10207-12. 2009
    ..Here we show that the synaptic nuclear anchorage is partially perturbed in Sun1, but not in Sun2, knockout mice...
  56. pmc The LINC-less granulocyte nucleus
    Ada L Olins
    Department of Biology, Bowdoin College, Brunswick, ME 04011, USA
    Eur J Cell Biol 88:203-14. 2009
    ..HL-60 granulocytes exhibited a deficiency of several LINC complex proteins (i.e. nesprin 1 giant, nesprin 2 giant, SUN1, plectin and vimentin); whereas, the macrophage state revealed nesprin 1 giant, plectin and vimentin...
  57. pmc Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:965-73. 2009
    ..b>Sun1 is an inner nuclear membrane (INM) protein that locates to telomeres and anchors chromosome movement in the ..
  58. pmc LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation
    Abigail B Vander Heyden
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 20:2661-72. 2009
    ..NE, TorA displaces the nuclear membrane proteins Sun2, nesprin-2G, and nesprin-3 while leaving nuclear pores and Sun1 unchanged. Wild-type TorA also induces changes in NE membrane structure...
  59. pmc Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1
    K Kominami
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Cell 8:171-87. 1997
    ..encoding proteins with related functions to Nin1p and have cloned and characterized two new multicopy suppressors, SUN1 and SUN2, of the nin1-1 mutation. SUN1 can suppress a null nin1 mutation, whereas SUN2, an essential gene, does not...
  60. doi Sun1 forms immobile macromolecular assemblies at the nuclear envelope
    Wenshu Lu
    Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
    Biochim Biophys Acta 1783:2415-26. 2008
    ..In the current study, we provide evidence that within the nuclear envelope (NE) Sun1 proteins form highly immobile oligomeric complexes in interphase cells...
  61. ncbi Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin
    Mirjam Ketema
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 120:3384-94. 2007
    ..and nesprin-2: the last four amino acids of the nesprin-3alpha KASH domain are essential for its interaction with Sun1 and Sun2...
  62. ncbi SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice
    Xu Ding
    Institute of Developmental Biology and Molecular Medicine and School of Life Science, Fudan University, Shanghai 200433, China
    Dev Cell 12:863-72. 2007
    ..Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I...
  63. pmc SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton
    Farhana Haque
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Mol Cell Biol 26:3738-51. 2006
    ..Here, we report the identification of SUN1 as a lamin A-binding protein in a yeast two-hybrid screen...
  64. ncbi Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X
    Jeffrey D Bray
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6142, USA
    Genomics 79:799-808. 2002
    ..429 amino acids with 73% homology to centrosomal Akap9; and a cDNA encoding 346 amino acids with 75% homology to SUN1, a predicted human protein that contains a SUN domain (which is present in some perinuclear proteins)...
  65. pmc Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane
    M Dreger
    Institute for Chemistry Biochemistry, Free University Berlin, Thielallee 63, D 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 98:11943-8. 2001
    ..The utility of our approach is not restricted to the investigation of the NE. Our approach should be applicable to the analysis of other complex membrane structures of the cell as well...
  66. pmc Rpn9 is required for efficient assembly of the yeast 26S proteasome
    J Takeuchi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    Mol Cell Biol 19:6575-84. 1999
    We have isolated the RPN9 gene by two-hybrid screening with, as bait, RPN10 (formerly SUN1), which encodes a multiubiquitin chain receptor residing in the regulatory particle of the 26S proteasome...
  67. pmc KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development
    Juehua Yu
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai 200433, China
    Hum Mol Genet 20:1061-73. 2011
    ..we demonstrated that a KASH domain-containing protein, Syne-2/Nesprin-2, as well as SUN domain-containing proteins, SUN1 and SUN2, play critical roles during INM and photoreceptor cell migration in the mouse retina...
  68. doi Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres
    Irene Schulz
    Department of Cell Biology, Institute for Biochemistry and Biology, University of Potsdam, Potsdam Golm, Germany
    Eur J Cell Biol 88:621-38. 2009
    ..There is still no common scheme for the outer nuclear membrane proteins interacting with Sun1 in centrosome/nucleus attachment...
  69. pmc Cohesin SMC1beta protects telomeres in meiocytes
    Caroline Adelfalk
    Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany
    J Cell Biol 187:185-99. 2009
    ..extended telomere bridges between SCs, ring-like chromosomes, intrachromosomal telomeric repeats, and a reduction of SUN1 foci in the NE. We suggest that a telomere structure protected from DNA rearrangements depends on SMC1beta.
  70. pmc Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins
    Cecilia Ostlund
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Sci 122:4099-108. 2009
    ..b>Sun1, Sun2 and nesprin-2 are important components of the LINC complex...
  71. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..We report here that the SUN-domain proteins SUN1 and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and ..
  72. doi The nucleoporin Nup153 maintains nuclear envelope architecture and is required for cell migration in tumor cells
    Lixin Zhou
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    FEBS Lett 584:3013-20. 2010
    ..by RNAi results in alteration of the organization of the nuclear lamina and the nuclear lamin-binding protein Sun1. More striking, Nup153 depletion induces a dramatic cytoskeletal rearrangement that impairs cell migration in human ..
  73. pmc Rap1-independent telomere attachment and bouquet formation in mammalian meiosis
    Harry Scherthan
    Institut für Radiobiologie der Bundeswehr in Verbindung mit der Universität Ulm, Neuherbergstr 11, 80937, Munich, Germany
    Chromosoma 120:151-7. 2011
    ..Furthermore, Rap1-deficient meiotic telomeres assemble the SUN1 nuclear membrane protein, attach to the NE, and undergo bouquet formation indistinguishable from the wild-type ..
  74. doi Functional analyses of lissencephaly-related proteins in Dictyostelium
    Irene Meyer
    Institute for Biochemistry and Biology, Department of Cell Biology, University of Potsdam, Potsdam, Germany
    Semin Cell Dev Biol 22:89-96. 2011
    ..Analyses of Dictyostelium SUN1 mutants have underscored the importance of these proteins for the linkage of centrosomes and nuclei and for the ..
  75. doi The LINC complex and human disease
    Peter Meinke
    Institute of Human Genetics, Fleischmannstrasse 42 44, D 17475 Greifswald, Germany
    Biochem Soc Trans 39:1693-7. 2011
    ..The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including ..
  76. pmc Expression of individual mammalian Sun1 isoforms depends on the cell type
    Eva Göb
    Department of Cell and Developmental Biology Biocenter University of Würzburg Am Hubland, Wurzburg Germany
    Commun Integr Biol 4:440-2. 2011
    Mammalian Sun1 belongs to an evolutionarily conserved family of inner nuclear membrane proteins, which are known as SUN domain proteins...
  77. pmc POM121 and Sun1 play a role in early steps of interphase NPC assembly
    Jessica A Talamas
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 194:27-37. 2011
    ..Overexpression of POM121 resulted in juxtaposition of the INM and ONM. Additionally, Sun1, an INM protein that is known to interact with the cytoskeleton, was specifically required for interphase assembly ..
  78. doi SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis
    Xian zhen Jiang
    Center for Medical Experiments, Third Xiang Ya Hospital of Central South University, Changsha, China
    DNA Cell Biol 30:875-82. 2011
    SUN domain-containing proteins belong to a novel protein family. To date, several members--SUN1, SUN2, SUN3, and SPAG4--have been identified as nuclear envelope (NE) proteins...
  79. pmc The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component
    Michael T Jungwirth
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
    BMC Cell Biol 12:24. 2011
    ..Although hypoactive, the DYT1 dystonia torA-ΔE isoform often concentrates in the NE, suggesting that torA-ΔE also interacts with an NE-localized binding partner...
  80. doi Samp1 is functionally associated with the LINC complex and A-type lamina networks
    Santhosh Gudise
    Department of Neurochemistry, Stockholm University, SE10691 Stockholm, Sweden
    J Cell Sci 124:2077-85. 2011
    ..characteristic pattern in the nuclear envelope (NE), where it partially colocalizes with the LINC complex protein Sun1. By studying the localization of Samp1 deletion mutants and fusion proteins, we conclude that the cysteine-rich N-..
  81. pmc Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane
    Erin C Tapley
    Department of Molecular and Cellular Biology, University of California, Davis, Davis CA 95616, USA
    Mol Biol Cell 22:1739-52. 2011
    ..sequences: two classical nuclear localization signals, an INM sorting motif, and a signal conserved in mammalian Sun1, the SUN--nuclear envelope localization signal...
  82. pmc Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity
    Daniel Jahn
    Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Germany
    Nucleus 1:273-83. 2010
    ..nuclear deformations and alters the distribution of the endogenous nuclear envelope proteins lamin B1, LAP2, SUN1 and SUN2...
  83. doi SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome
    Cornelia Frohnert
    Johann Friedrich Blumenbach Institute of Zoology and Anthropology Developmental Biology, Georg August Universitat Gottingen, GZMB, Ernst Caspari Haus, Justus von Liebig Weg 11, Gottingen, Germany
    Mol Hum Reprod 17:207-18. 2011
    ..In contrast to the widely expressed SUN domain proteins in mammals, SUN1 and SUN2, which have been analysed in great detail, there is virtually nothing known about testicular SUN domain ..

Research Grants5

  1. Ju Chen; Fiscal Year: 2015
    ..In addition, we observed upregulation of protein levels of SUN1, a Nesprin 1 binding partner and an inner nuclear membrane protein, in Nesprin 1-/- heart samples...
  2. Lamin A in Adipocyte Differentation and Survival
    Howard Worman; Fiscal Year: 2004
    ..Confirmation of this hypothesis will have implications for the identification of new cellular targets to treat human obesity and diabetes mellitus. ..
  3. DUX4 and Facioscapulohumeral Muscular Dystrophy
    Howard Worman; Fiscal Year: 2004
    ..This work could lead to the development of new diagnostic methods as well as the identification of potential protein targets for the treatment of FSHD. ..
  4. Lamin A Mutation and Hutchinson-Gilford Progeria
    Howard Worman; Fiscal Year: 2008
    ..This project will establish how mutations in nuclear lamins A and C cause HGPS, and if inhibition of protein farnesylation is a potential therapeutic intervention. ..
  5. NUCLEAR DIFFERENTATION DURING MURINE GRANULOPOIESIS
    DONALD OLINS; Fiscal Year: 2004
    ..abstract_text> ..