SULT1A1

Summary

Gene Symbol: SULT1A1
Description: sulfotransferase family 1A member 1
Alias: HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1, sulfotransferase 1A1, P-PST 1, aryl sulfotransferase 1, phenol-sulfating phenol sulfotransferase 1, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, thermostable phenol sulfotransferase1, ts-PST
Species: human

Top Publications

  1. ncbi Association of the SULT1A1 R213H polymorphism with colorectal cancer
    Chung Fai Wong
    Department of Physiology and Pharmacology, University of Queensland, Princess Alexandra Hospital, St Lucia, Brisbane, QLD 4102, Australia
    Clin Exp Pharmacol Physiol 29:754-8. 2002
  2. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study
    Leizhen Zheng
    Department of Epidemiology Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Lett 202:61-9. 2003
  3. ncbi Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups
    Kyoung Ah Kim
    Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, 405 760, Korea
    Eur J Clin Pharmacol 61:743-7. 2005
  4. ncbi The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates
    Niranjali U Gamage
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 280:41482-6. 2005
  5. pmc Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study
    Ekaterina G Shatalova
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 7:R909-21. 2005
  6. ncbi Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians
    Susan Nowell
    University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, Arkansas, USA
    Cancer Epidemiol Biomarkers Prev 13:270-6. 2004
  7. ncbi A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking
    Gang Liang
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 25:773-8. 2004
  8. ncbi Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population
    Shogo Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Int J Cancer 102:418-21. 2002
  9. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study
    Deliang Tang
    Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
    Breast Cancer Res Treat 78:217-22. 2003
  10. ncbi Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype
    R B Raftogianis
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    Biochem Biophys Res Commun 239:298-304. 1997

Research Grants

Detail Information

Publications235 found, 100 shown here

  1. ncbi Association of the SULT1A1 R213H polymorphism with colorectal cancer
    Chung Fai Wong
    Department of Physiology and Pharmacology, University of Queensland, Princess Alexandra Hospital, St Lucia, Brisbane, QLD 4102, Australia
    Clin Exp Pharmacol Physiol 29:754-8. 2002
    ..The arylsulphotransferase SULT1A1 has been implicated in a decreased activity and thermostability when the wild-type arginine at position 213 of ..
  2. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study
    Leizhen Zheng
    Department of Epidemiology Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Lett 202:61-9. 2003
    ..b>SULT1A1 appears to be an important phenol SULT because of its abundance and distribution in many tissues and wide ..
  3. ncbi Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups
    Kyoung Ah Kim
    Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, 405 760, Korea
    Eur J Clin Pharmacol 61:743-7. 2005
    ..To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups...
  4. ncbi The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates
    Niranjali U Gamage
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 280:41482-6. 2005
    Human SULT1A1 belongs to the supergene family of sulfotransferases (SULTs) involved in the sulfonation of xeno- and endobiotics...
  5. pmc Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study
    Ekaterina G Shatalova
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Breast Cancer Res 7:R909-21. 2005
    Estrogens are important in breast cancer development. SULT1A1 and UGT1A1 catalyze estrogen metabolism and are polymorphic...
  6. ncbi Association of SULT1A1 phenotype and genotype with prostate cancer risk in African-Americans and Caucasians
    Susan Nowell
    University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, Arkansas, USA
    Cancer Epidemiol Biomarkers Prev 13:270-6. 2004
    Exposure to heterocyclic amines may increase prostate cancer risk. Human sulfotransferase 1A1 (SULT1A1) is involved in the bioactivation of some dietary procarcinogens, including the N-hydroxy metabolite of the food-borne heterocyclic ..
  7. ncbi A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking
    Gang Liang
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 25:773-8. 2004
    b>Sulfotransferase 1A1, an important member of sulfotransferase superfamily, is involved in the biotransformation of many compounds including tobacco carcinogens...
  8. ncbi Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population
    Shogo Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Int J Cancer 102:418-21. 2002
    ..CYP) 1A2 and subsequently through O-sulfation and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
  9. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study
    Deliang Tang
    Department of Environmental Health Sciences, Joseph L Mailman School of Public Health, Columbia University, New York City, NY 10032, USA
    Breast Cancer Res Treat 78:217-22. 2003
    ..between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts...
  10. ncbi Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype
    R B Raftogianis
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    Biochem Biophys Res Commun 239:298-304. 1997
    ..Three highly homologous PST genes, SULT1A1, SULT1A2, and SULT1A3, are known to exist in humans...
  11. ncbi Human SULT1A1 gene: copy number differences and functional implications
    Scott J Hebbring
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Mol Genet 16:463-70. 2007
    b>SULT1A1, which catalyzes the sulfate conjugation of a wide variety of natural and synthetic compounds, is genetically polymorphic...
  12. ncbi Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 16:444-50. 2007
    ..interactions in African Americans and European Americans for genotypes at COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SULT1A1, and SULT1E1 in 878 breast cancer cases and 1,409 matched random digit-dialed controls...
  13. ncbi Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism
    J Gjerde
    The Hormone Laboratory, Haukeland University Hospital, N 5021 Bergen
    Ann Oncol 19:56-61. 2008
    ..Clinical studies indicate that CYP2D6 and SULT1A1 genotypes are predictors for treatment response to tamoxifen...
  14. pmc Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk
    A Kotnis
    Genetic Engineering Unit, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India
    Br J Cancer 99:1340-7. 2008
    Cytosolic sulphotransferase SULT1A1 plays a dual role in the activation of some carcinogens and inactivation of others...
  15. ncbi Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer
    Eliane Kellen
    Department of General Practice, Comprehensive Cancer Institute Limburg, Katholieke Universiteit Leuven, Belgium
    Int J Cancer 118:2572-8. 2006
    ..We also evaluated interaction between fruit intake and GSTM1, GSTT1, NAT2 and SULT1A1 amongst "ever-smokers...
  16. ncbi Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes
    R M Weinshilboum
    Department of Pharmacology, Mayo Medical School Mayo Clinic Mayo Foundation, Rochester, Minnesota 55905, USA
    FASEB J 11:3-14. 1997
    ..ST enzymes are members of an emerging gene superfamily that presently includes phenol ST (PST), hydroxysteroid ST (HSST), and, in plants, flavonol ST (FST) "families," members of which share at least 45% amino ..
  17. ncbi The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese
    Ching Tien Peng
    Department of Molecular Medicine and Pediatrics, China Medical College Hospital, Taichung, Taiwan, ROC
    Int J Mol Med 11:85-9. 2003
    ..The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in the level of ..
  18. pmc Association of sulfotransferase SULT1A1 with breast cancer risk: a meta-analysis of case-control studies with subgroups of ethnic and menopausal statue
    Yiwei Jiang
    Department of Breast Surgery, Shanghai Cancer Hospital Cancer Institute, Fudan University, Shanghai 200032, China
    J Exp Clin Cancer Res 29:101. 2010
    ..Polymorphism of the SULT1A1 may be closely associated with breast cancer...
  19. pmc UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients
    Rachel Sparks
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R488-98. 2004
    ..five UGT and SULT genes - UGT1A1 ((TA)6/(TA)7), UGT2B4 (Asp458Glu), UGT2B7 (His268Tyr), UGT2B15 (Asp85Tyr), and SULT1A1 (Arg213His)--may be associated with circulating sex hormone concentrations, or the risk of an estrogen receptor-..
  20. ncbi Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy
    J L Grabinski
    University of Texas College of Pharmacy, Austin, USA
    Breast Cancer Res Treat 95:13-6. 2006
    Human sulfotransferase 1A1 (SULT1A1) is involved in the metabolism of a number of substances including 4-hydroxytamoxifen. It has been shown that patients who are homozygous for the variant SULT1A1 *2/*2 have lower catalytic activity...
  21. ncbi Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer
    P Seth
    Departent of Adult Oncology, Dana Farher Cancer Institute, Boston, Massachasetts 02115, USA
    Cancer Res 60:6859-63. 2000
    ..Using an RFLP that distinguishes an arginine to histidine change in exon 7 of the SULT1A1 gene, we characterized SULT1A1 genotypes in relation to breast cancer risk...
  22. pmc Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    Pia Wegman
    Department of Biomedicine and Surgery, Division of Cellbiology, Faculty of Health Sciences, Linkoping, Sweden
    Breast Cancer Res 7:R284-90. 2005
    ..Cytochrome P450 2D6 (CYP2D6) and sulfotransferase 1A1 (SULT1A1) are polymorphic and are involved in the metabolism of tamoxifen...
  23. ncbi Sulfotransferase1A1 and risk of postmenopausal breast cancer
    Piiha Lotta Jerevall
    Department of Biomedicine and Surgery, Division of Cellbiology, Faculty of Health Sciences, University Hospital, S 581 85 Linkoping, Sweden
    Anticancer Res 25:2515-7. 2005
    The detoxification enzyme sulfotransferase1A1 (SULT1A1) is implicated in the inactivation of estrogens and the activation of promutagens and procarcinogens...
  24. ncbi Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk
    O N Mikhailova
    Institute of Molecular Biology and Biophysics, Novosibirsk, Russia
    Pharmacogenomics J 6:189-93. 2006
    Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (Aromatase) and II-phase enzyme Sulfotransferase (SULT1A1) genes are associated with a high risk of hormone-dependent cancers...
  25. doi Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia
    Lyudmila F Gulyaeva
    Institute of Molecular Biology and Biophysics, Academy of Medical Sciences, Novosibirsk, Russia
    Adv Exp Med Biol 617:359-66. 2008
    We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) ..
  26. pmc Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies
    M E Veronese
    Department of Clinical Pharmacology, Flinders University of South Australia, Adelaide
    Biochem J 302:497-502. 1994
    ..that HAST1 was considerably more thermostable (TS) than HAST3, which is consistent with P-PST being termed the TS PST and M-PST being termed the thermolabile (TL) PST...
  27. ncbi Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7
    T P Dooley
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228
    Genomics 18:440-3. 1993
    We have recently cloned a cDNA encoding the human phenol-preferring phenol sulfotransferase (P-PST) enzyme...
  28. ncbi Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16
    T P Dooley
    Southern Research Institute, Birmingham, Alabama 35205, USA
    Biochem Biophys Res Commun 228:134-40. 1996
    ..the STM gene encoding the monoamine neurotransmitter-preferring sulfotransferase, M-PST, and a portion of the STP1 gene encoding the phenol-preferring isozyme, P-PST1 (BBRC 205, 1325-1332; Genomics 18, 440-443)...
  29. ncbi Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2
    C E Engelke
    Department of Toxicology, German Institute of Human Nutrition Potsdam Rehbrucke
    Pharmacogenetics 10:163-9. 2000
    Three human phenol sulfotransferases, provisionally named SULT1A1, 1A2 and 1A3, show 91-96% homology of their amino acid sequences and are encoded by neighbouring gene loci...
  30. ncbi Sulfotransferases in the bioactivation of xenobiotics
    H Glatt
    Department of Toxicology, Deutsches Institut für Ernährungsforschung DIfE, Arthur Scheunert Allee 114 116, D 14558, Potsdam Rehbrucke, Germany
    Chem Biol Interact 129:141-70. 2000
    ..Common functionally relevant genetic polymorphisms of the transcribed region are known for two of the forms, SULT1A1 and 1A2...
  31. ncbi N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast
    J A Williams
    Institute of Cancer Research, Haddow Laboratories, Sutton, UK
    Pharmacogenetics 11:373-88. 2001
    ..Western blot analysis of mammary cytosolic protein showed detectable levels of SULT1A1 and SULT1A3.
  32. ncbi Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects
    H Glatt
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, D 14558 Potsdam Rehbrücke, Germany
    Mutat Res 482:27-40. 2001
    ..Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls...
  33. ncbi Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis
    Yunfei Wang
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 35:137-42. 2002
    b>SULT1A1 enzyme is a member of the sulfotransferase family that alters biological activities of numerous carcinogenic and mutagenic compounds through sulfation...
  34. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate ..
  35. ncbi SULT1A1 polymorphism and esophageal cancer in males
    Ming Tsang Wu
    Graduate Institute of Occupational Safety and Health and Department of Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Cancer 103:101-4. 2003
    ..It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at ..
  36. ncbi Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition
    Niranjali U Gamage
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 278:7655-62. 2003
    ..A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ..
  37. ncbi Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk
    Monique Saintot
    Groupe d Epidémiologie Métabolique, INSERM CRLC, Montpellier, France
    Int J Cancer 107:652-7. 2003
    ..ORi) between smoking habits and the gene polymorphisms of Cytochrome P450 1B1 (Val432Leu CYP1B1), Phenol-sulfotransferase 1A1 (Arg213His SULT1A1) and Catechol-O-methyltransferase (Val158Met COMT)...
  38. ncbi Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer
    Hiromasa Tsukino
    Department of Public Health, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, 889 1692, Japan
    J Cancer Res Clin Oncol 130:99-106. 2004
    ..Recently, several polymorphisms of CYP1A2, SULT1A1, and NAT2 that affect their activities have been reported.
  39. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women
    Ding Fen Han
    Department of Clinical Epidemiology, Public Health School of Wuhan University, Wuhan, China
    Toxicol Lett 150:167-77. 2004
    ..A major human sulfotransferase, SULT1A1, catalyzes the sulfation of a variety of phenolic and estrogenic compounds...
  40. ncbi GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 110:598-604. 2004
    ..Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines...
  41. ncbi Genetic variants of the sulfotransferase 1A1 and breast cancer risk
    Uwe Langsenlehner
    Department of Internal Medicine, Division of Oncology, Medical University Graz, Graz, Austria
    Breast Cancer Res Treat 87:19-22. 2004
    b>Sulfotransferase 1A1 (SULT1A1), also designated as phenol-preferring sulfotransferase, is involved in the bioactivation and detoxification of a variety of potential carcinogens, including iodothyronines, hydroxylated aromatic amines, and ..
  42. ncbi Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility
    Ting Chih Cheng
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 113:345-53. 2005
    ..by conjugation reactions involving methylation (catechol-O-methyltransferase, COMT), sulfation (sulfotransferase 1A1, SULT1A1), or glucuronidation (UDP-glucuronosyltransferase 1A1, UGT1A1), one (manganese superoxide ..
  43. ncbi CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer
    Priya Chacko
    Division of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram 695011, Kerala State, India
    Breast Cancer 11:380-8. 2004
    ..The CYP17 and SULT1A1 genes encode for two enzymes involved in hormone biosynthesis and metabolism...
  44. ncbi CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    Yan Jin
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 97:30-9. 2005
    ....
  45. pmc SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Breast Cancer Res 7:R229-37. 2005
    b>Sulfotransferase 1A1 (encoded by SULT1A1) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are present in tobacco smoke...
  46. ncbi Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
    Ji Yeob Choi
    Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon dong Chongno gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 14:1090-5. 2005
    We examined whether common single nucleotide polymorphisms (SNP) in SULT1A1 (c.779G>A, *14A>G, and *85C>T) and SULT1E1 (IVS1-447C>A, IVS4-1653T>C, and *959G>A) genes influenced the risk and survival of breast cancer...
  47. ncbi Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer
    Wogelsanger O Pereira
    Departamento de Bioquimica, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Cancer Genet Cytogenet 160:55-60. 2005
    ..A mutation in the SULT1A1 gene has been associated with decreased sulfotransferase activity...
  48. ncbi Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 91:249-58. 2005
    ..We also examined whether the combination of variant alleles in SULT1A1 and UGT2B15 had more of an impact on overall survival in tamoxifen-treated patients than when the genes were ..
  49. ncbi Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study
    Stefania Boccia
    Institute of Hygiene, Catholic University of Sacred Heart, L go F Vito, 1, 00168 Rome, Italy
    Cancer Lett 229:235-43. 2005
    ..The SULT1A1 gene possesses a G-->A polymorphism that results in a Arg to His substitution at codon 213, and the His allele ..
  50. ncbi Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women
    Pia Sillanpää
    Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenet Genomics 15:749-52. 2005
    ..A polymorphism in the sulfotransferase 1A1 gene (SULT1A1) results in an amino acid change from Arg to His at codon 213...
  51. ncbi Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study
    Ding Fen Han
    Clinical Laboratory Center Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Chin Med J (Engl) 118:1507-16. 2005
    ..of genes responsible for estrogen biosynthesis (CYP17, cytochrome P450c17a and CYP19, aromatase cytochrome P450) and estrogen sulfation of inactivation (SULT1A1, sulfotransferase1A1) and the risk of breast cancer in Chinese women.
  52. ncbi Estrogen bioactivation, genetic polymorphisms, and ovarian cancer
    Thomas A Sellers
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33602, USA
    Cancer Epidemiol Biomarkers Prev 14:2536-43. 2005
    ..polymorphisms in four genes involved in catechol estrogen formation (CYP1A1 and CYP1B1) or conjugation (COMT and SULT1A1)...
  53. ncbi A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer
    Stefania Boccia
    Institute of Hygiene, Catholic University of the Sacred Heart, L go F Vito 1, 00168 Rome, Italy
    J Cancer Res Clin Oncol 132:466-72. 2006
    Sulfotransferases (SULT) 1A1 detoxify and bio-activate a broad spectrum of substrates including xenobiotics. The SULT1A1 gene possesses a G-->A polymorphism that results in an Arg to His substitution at codon 213, with the His allele ..
  54. ncbi SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    Several procarcinogens that are present in cooked red meat and tobacco smoke are substrates for sulfotransferase 1A1 (SULT1A1)...
  55. pmc Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    Pia Wegman
    Department of Biomedicine and Surgery, Division of Cell Biology, Faculty of Health Sciences, Linkoping University, 581 85 Linkoping, Sweden
    Breast Cancer Res 9:R7. 2007
    ..and/or predictive value of functional polymorphisms in cytochrome P450 3A5 CYP3A5 (*3), CYP2D6 (*4), sulphotransferase 1A1 (SULT1A1; *2) and UDP-glucuronosyltransferase 2B15 (UGT2B15; *2) in tamoxifen-treated patients with breast cancer.
  56. ncbi [A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]
    Kun Chen
    Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou 310031, China
    Zhonghua Zhong Liu Za Zhi 28:670-3. 2006
    ..To investigate the relationship between sulfotransferase 1Al polymorphism, diet and colorectal cancer susceptibility...
  57. pmc Structural and chemical profiling of the human cytosolic sulfotransferases
    Abdellah Allali-Hassani
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 5:e97. 2007
    ..The data help explain substrate promiscuity in this family and, at the same time, reveal new similarities between hSULT family members that were previously unrecognized by sequence or structure comparison alone...
  58. pmc Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer
    Chunhong Fan
    Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China
    BMC Cancer 7:115. 2007
    ..Our objective was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC).
  59. ncbi Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors
    F Bardakci
    Department of Biology, Faculty of Science and Literature, Adnan Menderes University, 09100 Aydin, Turkey
    J Cancer Res Clin Oncol 134:109-14. 2008
    b>Sulfotransferase 1A1 is a member of sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation...
  60. ncbi Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan
    Yuan Hung Wang
    School of Public Health, Topnotch Stroke Research Center, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Cancer Res Clin Oncol 134:203-9. 2008
    To investigate whether the NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms are associated with urothelial cancer (UC) risk in Taiwan.
  61. pmc Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population
    Stefania Boccia
    Genetic Epidemiology and Molecular Biology Unit, Institute of Hygiene, Universita Cattolica del Sacro Cuore, Rome, Italy
    BMC Cancer 7:206. 2007
    ..The distribution and the potential gene-gene and gene-environment interaction of selected metabolic genetic polymorphisms was investigated in relation to gastric cancer risk in an Italian population...
  62. ncbi Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma
    Morgan Roupret
    Royal Hallamshire Hospital, Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:2500-3. 2007
    Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer...
  63. doi CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility
    Hiroshi Hirata
    Department of Urology, University of California at San Francisco, San Francisco, CA 94121, USA
    Cancer 112:1964-73. 2008
    ..The authors hypothesized that single nucleotide polymorphisms (single nucleotide polymorphisms) of CYP1A1, CYP1A2, CYP1B1, CYP17, SULT1A1, SULT1E1, and SHBG genes may be risk factors for endometrial cancer.
  64. doi Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population
    Hidekazu Koike
    Maebashi, 3718511, Japan
    Int Urol Nephrol 40:947-51. 2008
    Sulfation is a key pathway in xenobiotic metabolism and chemical defense, and phenol sulfotransferase SULT1A1 plays a central role in this reaction...
  65. pmc Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk
    Michelle Cotterchio
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
    Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008
    ..associated with increased colorectal cancer risk regardless of genotypes; however, CYP1B1 combined variant and SULT1A1-638G>A variant significantly modified the association between red meat doneness intake and colorectal cancer ..
  66. doi Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population
    Yuan Hung Wang
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    Int J Urol 15:1029-34. 2008
    To investigate the association between genetic polymorphism of sulfotransferase1A1 (SULT1A1), cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population.
  67. doi An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population
    Serdal Arslan
    Department of Molecular Biology and Genetics, Faculty of Science and Literature, Sivas, Turkey
    Cell Biochem Funct 27:211-5. 2009
    Human sulfotransferase 1A1 (SULT1A1), the most expressed isoform of the phenol SULT1 subfamily, is an important member of sulfotransferase superfamily. A transition, G to A at position 638, in SULT1A1 gene, results in Arg(213)His change...
  68. doi Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population
    Volga S Syamala
    Regional Cancer Centre, Division of Cancer Research, Medical College Post, Thiruvananthapuram, India
    Cancer Invest 28:304-11. 2010
    ..whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk...
  69. doi SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls
    Zhanwei Wang
    Department of Epidemiology and Biostatistics, Nanjing Medical University, 210029 Nanjing, China
    Breast Cancer Res Treat 122:193-8. 2010
    The SULT1A1 R213H polymorphism is suggested to be implicated in the development and progression of breast cancer. However, the published findings are inconsistent...
  70. doi Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer
    Gudrun Knechtel
    Department of Internal Medicine, Division of Oncology, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Cancer Res Clin Oncol 136:1813-9. 2010
    ..We assessed the influence of 16 selected common germline polymorphisms in disease-free survival and overall survival among 216 women diagnosed with lymph node-positive breast cancer...
  71. doi Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial
    D Serrano
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
    Pharmacogenomics J 11:100-7. 2011
    ..role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial...
  72. doi SULT1A1 Arg213His polymorphism and susceptibility of environment-related cancers: a meta analysis of 5,915 cases and 7,900 controls
    Kun Li
    Department of Epidemiology, School of Public Health, China Medical University, No 92 Beier Road, Heping District, Shenyang, 110001 Liaoning Province, China
    Mol Biol Rep 39:2597-605. 2012
    The common genetic polymorphism for SULT1A1 is Arg213His polymorphism, which may affect the sulfation process of various environmental carcinogens and thus is suggested to be related to susceptibility of several cancers...
  73. doi SULT1A1 Arg213His polymorphism, smoked meat, and breast cancer risk: a case-control study and meta-analysis
    Hui Lee
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 31:688-99. 2012
    b>SULT1A1 is involved in both detoxification of estrogens and bioactivation of carcinogens in smoked meat. SULT1A1 Arg213His polymorphism's effect on breast cancer risk is still unclear...
  74. pmc Hypothesis: holiday sudden cardiac death: food and alcohol inhibition of SULT1A enzymes as a precipitant
    Ken Eagle
    J Appl Toxicol 32:751-5. 2012
    ..This hypothesis also raises parallels between sudden cardiac death in adults and Sudden Infant Death Syndrome (SIDS). The possible involvement of SULT1A inhibition in SIDS is discussed...
  75. ncbi Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects
    E J Carlini
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School Mayo Graduate School Mayo Clinic, Rochester, MN 55905, USA
    Pharmacogenetics 11:57-68. 2001
    ..The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in levels of ..
  76. ncbi Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk
    W Zheng
    Vanderbilt Ingram Cancer Center and Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, Tennessee 37232 8300, USA
    Cancer Epidemiol Biomarkers Prev 10:89-94. 2001
    ..A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene was reported recently, and individuals homozygous for the His allele have a substantially lower activity of ..
  77. ncbi Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer
    D E Bamber
    Clinical Biochemistry Research Laboratory, Centre for Cell and Molecular Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, UK
    Pharmacogenetics 11:679-85. 2001
    ..A major sulphotransferase (SULT) enzyme in humans, SULT1A1, is polymorphic with the most common variant allele, SULT1A1*2, occurring at a frequency of about 32% in the ..
  78. ncbi Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
    Susan Nowell
    S Nowell, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, USA
    J Natl Cancer Inst 94:1635-40. 2002
    Human sulfotransferase 1A1 (SULT1A1) catalyzes the sulfation of a variety of phenolic and estrogenic compounds, including 4-hydroxytamoxifen (4-OH TAM), the active metabolite of tamoxifen...
  79. ncbi Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3
    Amanda C Barnett
    School of Biomedical Sciences, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 279:18799-805. 2004
    Human SULT1A1 is primarily responsible for sulfonation of xenobiotics, including the activation of promutagens, and it has been implicated in several forms of cancer...
  80. ncbi Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
    ..The findings provide no evidence for a role of COMT Val58Met, CYP1A1*2A, CYP3A4*1B, CYP1B1 Leu432Val, SULT1A1 Arg213His, and AHR Arg554Lys in breast cancer etiology...
  81. ncbi Modifying effects of sulfotransferase 1A1 gene polymorphism on the association of breast cancer risk with body mass index or endogenous steroid hormones
    Gong Yang
    Department of Medicine, Center for Health Services Research and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Breast Cancer Res Treat 94:63-70. 2005
    ..The SULT1A1 genotype was not associated with overall breast cancer risk in this population...
  82. ncbi Gene-environment interaction: the role of SULT1A1 and CYP3A5 polymorphisms as risk modifiers for squamous cell carcinoma of the oesophagus
    Collet Dandara
    UCT MRC Oesophageal Cancer Research Group, Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine IIDMM, Groote Schuur Hospital, Faculty of Health Sciences, University of Cape Town, South Africa
    Carcinogenesis 27:791-7. 2006
    ..In this study we investigated a functional polymorphism in the SULT1A1 gene in 245 patients and 288 controls...
  83. pmc Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival
    Xiao Feng Sun
    Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, S 581 85 Linkoping, Sweden
    World J Gastroenterol 11:6875-9. 2005
    To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.
  84. ncbi Impact of polymorphism in sulfotransferase gene on the risk of lung cancer
    Suparna S Pachouri
    Department of Biotechnology, Panjab University, Chandigarh, India
    Cancer Genet Cytogenet 171:39-43. 2006
    ..b>Sulfotransferase 1A1 (SULT1A1) is active toward a wide range of substrates, including environmental and tobacco carcinogens...
  85. ncbi Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas
    Edine W Tiemersma
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Int J Cancer 108:97-103. 2004
    ..smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by SULT1A1. A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and ..
  86. ncbi Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs
    Mette Gaustadnes
    Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
    Hum Mutat 27:187-94. 2006
    ..92945042C>T (3'UTR 96516), GSTP1 c.342A>C (p.Ile105Val), GSTM1 c.573C>G (p.Lys173Asn), and SULT1A1 g.19934792G>A (p.Arg213His). All were borderline significant, and none were significant at the 5% level...
  87. ncbi Histidine residues in human phenol sulfotransferases
    Guangping Chen
    Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    Biochem Pharmacol 67:1355-61. 2004
    ..The universal sulfuryl donor is adenosine 3'-phosphate-5'-phosphosulfate. Human simple phenol sulfotransferase (P-PST) is one of the major human sulfotransferases that catalyze the sulfation of most phenols...
  88. ncbi Pharmacogenetics of antihypertensive drug responses
    Gary L Schwartz
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Pharmacogenomics 4:151-60. 2004
    ..including N-acetyltransferase (NAT2), catechol-O-methyltransferase (COMT), and phenol sulfotransferase (P-PST, SULT1A1)...
  89. ncbi Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis
    D P Ringer
    Biochemical Pharmacology Section, Samuel Roberts Noble Foundation, Inc, Ardmore, Oklahoma
    Mol Carcinog 9:2-9. 1994
    ..These patterns may correspond, respectively, to cytotoxic and genotoxic mechanisms of 2AAF action...
  90. ncbi Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes
    Zhengbo Duanmu
    Institute of Environmental Health Sciences, Wayne State University, 2727 Second Avenue, Detroit, Michigan 48201, USA
    Drug Metab Dispos 30:997-1004. 2002
    ..in humans, the effects of DEX treatment on hydroxysteroid sulfotransferase (SULT2A1) and aryl sulfotransferase (SULT1A1) gene expression were investigated in primary cultured human hepatocytes...
  91. ncbi Affinity labeling of aryl sulfotransferase IV. Identification of a peptide sequence at the binding site for 3'-phosphoadenosine-5'-phosphosulfate
    Y Zheng
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City 52242
    J Biol Chem 269:30313-9. 1994
    ....
  92. ncbi In vivo and in vitro oxidative regulation of rat aryl sulfotransferase IV (AST IV)
    Smarajit Maiti
    Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA
    J Biochem Mol Toxicol 19:109-18. 2005
    ....
  93. ncbi Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization
    T C Wood
    Department of Pharmacology, Mayo Medical School Mayo Clinic, Rochester, MN 55905
    Biochem Biophys Res Commun 198:1119-27. 1994
    ..of phenolic biogenic amines in humans is catalyzed by the thermolabile (TL) form of phenol sulfotransferase (PST)...
  94. pmc Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bed
    V Ralevic
    Department of Anatomy and Developmental Biology, University College London
    Br J Pharmacol 114:1541-8. 1995
    ..The P1-purinoceptor antagonist, 8-para-sulphophenyltheophylline (8-pST; 3 microM) inhibited vasodilator responses to NAD (pKB of 6.61 +/- 0.21, n = 7) and adenosine (pKB of 5.78 +/- 0...
  95. ncbi Regulation of expression of the amino acid transporter gene BAP3 in Saccharomyces cerevisiae
    M de Boer
    Department of Biochemistry and Molecular Biology, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Mol Microbiol 30:603-13. 1998
    ..in pre-tRNA maturation and also required for the expression of BAP2, as induction is no longer observed in an stp1 - mutant...
  96. ncbi Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1
    S Mesia-Vela
    Laboratory for Cellular and Biochemical Toxicology, College of Pharmacy, Rutgers University, NJ, USA
    Phytomedicine 8:481-8. 2001
    ..Assays were performed using recombinant phenolsulfotransferase (SULT1A1) and hydroxysteroidsulfotransferase (SULT2A1)...
  97. pmc Regulation and intracellular localization of Saccharomyces cerevisiae strand exchange protein 1 (Sep1/Xrn1/Kem1), a multifunctional exonuclease
    W D Heyer
    Institute of General Microbiology, University of Bern, Switzerland
    Mol Cell Biol 15:2728-36. 1995
    The Saccharomyces cerevisiae strand exchange protein 1 (Sep1; also referred to as Xrn1, Kem1, Rar5, or Stp beta) catalyzes the formation of hybrid DNA from model substrates in vitro...
  98. ncbi Cloning of the human phenol sulfotransferase gene family: three genes implicated in the metabolism of catecholamines, thyroid hormones and drugs
    T P Dooley
    Southern Research Institute, Birmingham, AL 35205, USA
    Chem Biol Interact 109:29-41. 1998
    ..in the identification of numerous PST cDNA isolates representing alleles of three human PST gene loci termed as STP1, STP2 and STM. All three genes have been mapped precisely to a small region on human chromosome 16p12.1-p11...
  99. ncbi Functional reconstitution of the solubilized Arabidopsis thaliana STP1 monosaccharide-H+ symporter in lipid vesicles and purification of the histidine tagged protein from transgenic Saccharomyces cerevisiae
    J Stolz
    , , Germany
    Plant J 6:225-33. 1994
    Complete DNA sequences encoding the Arabidopsis thaliana STP1 monosaccharide/H+ symporter or a histidine-tagged STP1-His6 protein were expressed in baker's yeast Saccharomyces cerevisiae...
  100. ncbi Studies on sulfation of synthesized metabolites from the local anesthetics ropivacaine and lidocaine using human cloned sulfotransferases
    C N Falany
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0001, USA
    Drug Metab Dispos 27:1057-63. 1999
    ..Five cloned human sulfotransferases (STs) were used in this study, namely, the phenol-sulfating form of ST (P-PST-1), the monoamine-sulfating form of ST (M-PST), estrogen-ST (EST), ST1B2, and dehydroepiandrosterone-ST (DHEA-ST), ..

Research Grants63

  1. Pharmacogenetics of Sulfate Conjugation
    VIRGIL JORDAN; Fiscal Year: 2006
    ..SULTI El is a distinct SULT isoform that also sulfates estrogens. We have recently identified three common SULT1A1 alleles with different frequencies in Caucasian and African American populations...
  2. CARCINOGENICITY OF 2-NITROPROPANE--A PROBABLE MECHANISM
    Emerich Fiala; Fiscal Year: 2000
    ....
  3. FLAVONOIDS BLOCK SULFATION-INDUCED CARCINOGEN ACTIVATION
    Thomas Walle; Fiscal Year: 1999
    ..Aim 1 will investigate the structure-activity relationship and kinetics for inhibition of human P form phenol-ST (P-PST) and dehydroepiandrosterone-ST (DHEA-ST) by flavonoids, using recombinant enzymes, model substrates for P-PST and ..
  4. ACTIVE SITE STUDIES OF HUMAN SULFOTRANSFERASES
    Guangping Chen; Fiscal Year: 2003
    ..acid residues in both the substrate- binding site and PAPS binding site of human liver phenol- sulfating ST (P-PST-1), dehydroepiandrosterone ST (DHEA-ST), and estrogen ST (EST). 2...
  5. SULFOTRANSFERASE EXPRESSION IN EPITHELIA AND CARCINOMAS
    THOMAS DOOLEY; Fiscal Year: 2001
    ..of the genes cloned and mapped by the applicant and his coworkers encode the phenol sulfotransferase gene loci, STP1, STP2, and STM...
  6. Improving Urinary Continence and Quality of Life in Prostate Cancer Patients
    Amy Y Zhang; Fiscal Year: 2012
    ..The interventions use a Problem-Solving Therapy (PST) framework to treat UI...
  7. CHARACTERIZATION OF HUMAN BRAIN SULFOTRANSFERASES
    JEROME ROTH; Fiscal Year: 1990
    ..As previously demonstrated, the soluble sulfotransferase (M and P-PST) in human brain are biochemically distinct from that isolated from common laboratory animals thus, making it ..
  8. Jonathan A Shaffer; Fiscal Year: 2016
    ..For his research project, Dr. Shaffer will conduct a dose- finding study and RCT of Problem-Solving Therapy (PST) for outpatients with HF and reduced quality of life (QoL)...
  9. Systems of Care for New Moms: Integrating Depression Treatment
    Luis H Zayas; Fiscal Year: 2010
    ..Problem Solving Therapy (PST) is suited to use by non-specialists and for in-home use...
  10. Enhanced Geriatric Depression Treatment in Adult Day Health Care
    Maria P Aranda; Fiscal Year: 2010
    ..the feasibility, acceptability, and effectiveness of adding individually administered Problem Solving Therapy (PST) to enhanced usual care as an approach for treating depression in adult day health care (ADHC) for predominantly ..
  11. Treating Depressed, Cognitively Impaired Elders
    Dimitris N Kiosses; Fiscal Year: 2010
    ..He proposes to use Problem Solving Therapy (PST) as his treatment framework and integrate in it compensatory strategies enabling patients to circumvent their ..
  12. Treating Older Patients with Major Depression and Severe COPD
    George S Alexopoulos; Fiscal Year: 2012
    ..We developed an intervention (PST-AE) that integrates treatment adherence enhancement procedures (AE) with problem solving therapy (PST)...
  13. Trina E Chang; Fiscal Year: 2016
    ..immediate career goal is to develop a research program testing an intervention based on problem-solving treatment (PST) to promote diabetes treatment adherence in an underserved Hispanic population;ultimately, she intends to build a ..
  14. BROOKE ANN HOLLISTER; Fiscal Year: 2016
    ..and early stage investigator that will evaluate the effectiveness of Case Management-Problem Solving Therapy (CM-PST) and Self-Guided Problem Solving Therapy (SG-PST) for depressed older adults living in a rural community...
  15. Providing Depression Care for Older Adult Substance Abusers at Community Agencies
    Daniel Rosen; Fiscal Year: 2012
    ..The Candidate's pilot work with older methadone clients identified Problem Solving Therapy. (PST) as the most appropriate therapeutic intervention for this population...
  16. Jordan F Karp; Fiscal Year: 2014
    ..plus a symptom-specific and age-appropriate intervention called Problem Solving Therapy for Depression and Pain (PST-DP) for older adults living with MDD and CLBP when primary pharmacotherapy with low-dose duloxetine and supportive ..
  17. Interpersonal therapy for depression in Breast Cancer
    Carlos Blanco; Fiscal Year: 2013
    ..a randomized clinical trial to compare the efficacy of Interpersonal Psychotherapy (IPT), Problem-Solving Therapy (PST), and Brief Supportive Psychotherapy (BSP) in alleviating depressive symptoms and improving quality of life for ..
  18. Tamoxifen biotransformation pathway pharmacogenomics
    MATTHEW PHILIP GOETZ; Fiscal Year: 2013
    ..to administer for the treatment of tamoxifen-induced hot flashes?;and 3) How do gene copy number differences in SULT1A1, which encodes the primary enzyme responsible for conjugation of the active tamoxifen metabolites, affect the ..
  19. George Demiris; Fiscal Year: 2014
    ..In this context, problem solving therapy (PST) provides an overall coping process that fosters adaptive situational coping and behavioral competence...
  20. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP2D6, CYP3A5, SULT1A1, UGT2B15) and drugs commonly used in polychemotherapy regimens for breast cancer including: cyclophosphamide (i.e...
  21. Regulation of SULT1A1 in Human Breast
    SUSAN A KADLUBAR; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Sulfotransferase isoform 1A1 (SULT1A1) is a Phase II xenobiotic metabolizing enzyme that catalyzes the sulfation of a host of structurally diverse endo- and xenobiotics, including tamoxifen (TAM) and ..
  22. JOHANNES NICOLAAS VAN DEN ANKER; Fiscal Year: 2014
    ..stage (defined by both gestational, and postnatal age) to UDP-glucuronosyltransferase 1A6 (UGT1A6) and sulfotransferase 1A1 (SULT1A1) activity. 2...
  23. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..We also have shown that expression of the two required polysialyltransferases (ST8Sia II/STX and ST8Sia IV/PST) is estrogen receptor-mediated...
  24. Treating Subthreshold Depression in Older Adults in Community-Based Rehab
    Amy Horowitz; Fiscal Year: 2009
    ..While there is extensive evidence for the effectiveness of Problem Solving Treatment for Primary Care (PST-PC) in major depression and some suggesting its potential for minor depression, there has been no work examining ..
  25. Global Regulation of Gene expression in Streptococcus pneumoniae
    Bernard Weisblum; Fiscal Year: 2010
    ..proteins regulate expression of the Piu heme transporter, and (3) To identify other genes regulated by the RitR/Stp/Stk complex...
  26. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    ....
  27. Pevention of Depression among Mothers of Young Children with Developmental Delay
    Emily Feinberg; Fiscal Year: 2009
    ..Three studies are planned to adapt and test a specific problem solving intervention, Problem Solving Treatment (PST), to prevent the onset and reoccurrence of depressive symptoms among mothers whose children are enrolled in the ..
  28. Problem-Solving Therapy for Treating Depression Among Patients with CHF
    ARTHUR NEZU; Fiscal Year: 2009
    ..intervention protocol to treat depression among this population as adapted from a Problem-Solving Therapy (PST) model...
  29. PST in Geriatric Depression with Executive Dysfunction
    Herbert Schulberg; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): This study proposes to compare the efficacy of Problem Solving Therapy (PST) to that of Supportive Therapy (ST) in non-demented elderly patients with major depression and cognitive impairment...
  30. Improving Function In Age-Related Macular Degeneration
    Barry Rovner; Fiscal Year: 2009
    ..clinical trial, the Improving Function in AMD Trial {IFAMD), to test the efficacy of Problem-Solving Treatment (PST) to improve vision function in older persons with age-related macular degeneration (AMD)...
  31. Problemsolving with parents of pediatric cancer survivor
    Avi Madan Swain; Fiscal Year: 2005
    ..study will implement a randomized clinical trial (RCT) comparing two intervention conditions: Problem-solving (PST) and Attention-Placebo Control (APC) - with 60 families of youth (2-18 years) who have just completed active ..
  32. Bonnie B Blomberg; Fiscal Year: 2014
    ..cytometry for cell surface Ig molecularly by detection of germ line transcripts (GLT) and post-switch transcripts (PST)...
  33. Stomate-based innate immunity against bacterial infection in Arabidopsis
    Maeli Melotto; Fiscal Year: 2012
    ..Specifically, stomata close in response to Escherichia coli O157:H7 and Pseudomonas syringae pv. tomato (Pst) DC3000 or bacterial PAMPs...
  34. Genetic Variation in Estrogen Sulfation Genes and Endometrial Cancer Risk
    VERONICA SETIAWAN; Fiscal Year: 2009
    ..associations between putative functional polymorphisms and tagging single nucleotide polymorphisms (SNPs) in SULT1A1, SULT1E1, STS and UGT1A1 with endometrial cancer risk, along with genexgene and genexenvironment interactions ..
  35. Calcium and Sodium Transport in Hypertension
    John M Hamlyn; Fiscal Year: 2012
    ..The effects of Digibind (antibodies that bind ouabain), PST-2238 (ouabain antagonist) and SEA0400 (NCX1 blocker), and of knock-down of [unreadable]2 Na+ pump or reduced NCX1 ..
  36. SUSANA NOEMI ASIN; Fiscal Year: 2016
    ..Sexually transmitted pathogens (STP) highly prevalent in HIV-endemic populations enhance HIV-1 infection and transmission...
  37. Mechanisms of selective glycolytic inhibition in ischemic kidney proximal tubles
    Babu J Padanilam; Fiscal Year: 2012
    Abstract Following ischemic renal injury (IRI), selective proximal straight tubule (PST) injury occurs in in vivo experimental models...
  38. NEUROBIOLOGY OF SLEEP APNEA IN AGING
    David W Carley; Fiscal Year: 2013
    ..Aim 1 will quantify impairments to: respiratory chemoreflexes, respiratory short term potentiation (STP) and respiratory long term facilitation (LTF) during wakfulness and sleep in animals that spontaneously exhibit ..
  39. Georgiana E Purdy; Fiscal Year: 2015
    ..2) To better understand intrinsic resistance of Mtb we will define the role of the ABC transporters Pst and Rv0986-Rv0987, and the MFS transporters Rv1634, and Rv3239c in the intrinsic resistance of Mtb...
  40. Mechanism of the Protein Specific Polysialylation of NCAM
    JOSEPH LOUIS ZAPATER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): ST8Sia IV (PST) is an 12,8-sialyltransferase that catalyzes the polysialylation of a limited number of substrate glycoproteins, with the neural cell adhesion molecule (NCAM) being the primary ..
  41. Processing Streams in the Cerebral Cortex
    Josef P Rauschecker; Fiscal Year: 2013
    ..In particular, we propose to study auditory areas within posterior superior temporal cortex (pST) and auditory-related areas in parietal and premotor cortex of awake rhesus monkeys...
  42. Jennifer Enright; Fiscal Year: 2014
    ..it will be the first transcription factor shown to drive avian photoreceptor diversification, a critical stp in exploiting this excellent model system for CNS diversification...
  43. Pavel Osten; Fiscal Year: 2016
    ..This method, which we call serial two- photon (STP) tomography, integrates two-photon laser-scanning microscopy and tissue sectioning...
  44. Vitaly A Klyachko; Fiscal Year: 2016
    ..While LTP is thought to play important roles in learning and memory, short-term plasticity (STP) is widely believed to control other essential neural functions such as information processing, working memory and ..
  45. ANNE MARIE R LANGEVIN; Fiscal Year: 2014
    The South Texas Pediatric Minority-Based Community Clinical Oncology Program (STP-MB-CCOP) was first formed in 1990, is currently in its 17th year of funding and is one of two solely pediatric CCOPs in the United States...
  46. CAMCI: Advancing the Use of Computerized Screening in Healthcare
    Amy Eschman; Fiscal Year: 2010
    ..Psychology Software Tools, Inc. (PST) has developed such a tool, the Computer Assessment of Mild Cognitive Impairment (CAMCI), a computerized screening ..
  47. Shengping Zheng; Fiscal Year: 2014
    ..Strongylophorine-26 is a promising Rho-dependent inhibitor of tumor cell invasion. It was observed that STP-26 reduces actin stress fibers and induces nonpolarized lamellipodial extensions...
  48. AGE, SENSATION AND FALLS--BIOMECHANICS AND PREVENTION
    Ge Wu; Fiscal Year: 1999
    ..2. To identify and classify the spatial-temporal patterns (STP) of body segmental kinematics and kinetics for successful and failed balance recoveries in healthy and sensory ..
  49. David H Wagner; Fiscal Year: 2014
    ..We designed a small (15-mer) therapeutic peptide (STP) derived from the CD154 amino acid sequence that is known to interact with CD40...
  50. Acceptance Enhanced Behavior Therapy for Trichotillomania
    Douglas W Woods; Fiscal Year: 2013
    ..to compare a 10 session manualized version of AEBT-T to a manualized psychoeducation and supportive therapy (PST) in adults with TTM...
  51. LOLAHON KADIRI; Fiscal Year: 2016
    ..entire mouse brain at celular resolution, using an automated high throughout microscopy called serial two-photon (STP) tomography...
  52. microBSD:Spatiotemporal control of neurochemical tone in the brain slice using mi
    Christopher P Fall; Fiscal Year: 2010
    ..jove.com/index/Details.stp?ID=302)...
  53. Muhammad Walji; Fiscal Year: 2016
    ..A Patient Safety Toolkit (PST) will be developed and validated for the documentation of adverse events in the dental setting...
  54. Complex Mouse Models of Age-related Macular Degeneration
    Caroline J Zeiss; Fiscal Year: 2013
    ..This need has provided the impetus for development of organizations such as the ACVP/STP Coalition for Veterinary Pathology Fellows...
  55. Lawrence L Wald; Fiscal Year: 2014
    ..Proof of principle in neuroimaging at 7T will also serve as a first stp toward the extension of this technology into other parts of the body.
  56. VERONICA RAQUEL FORTINO; Fiscal Year: 2015
    ..The contribution of this project will be significant because it is the initial stp in a continuum of research towards a long-term stem-cell based treatment designed specifically to address DPN.
  57. HORMONAL CONTROL OF HYPOTHALAMIC DOPAMINE SECRETION
    John Porter; Fiscal Year: 1992
    ..The radiolabelled RNA probe, cRNA, will be synthesized using TH cDNA, pTH.4, that was subcloned into the Pst I/Eco RI sites of pSP65 vector...
  58. RETROVIRAL GAG PROTEIN BINDING TO TYROSINE KINASES
    CORALIE CARRAWAY; Fiscal Year: 2001
    ..Purified p58 binds to mf, phospholipid and a membrane glycoprotein of a mf-associated signal transduction particle (STP)...
  59. ADRENERGIC VASOREGULATORY INTERACTIONS IN HYPERTENSION
    Richard Weinshilboum; Fiscal Year: 1980
    ..to include two additional catecholamine metabolic enzymes, monoamine oxidase (MAO) and phenol sulphotransferase (PST). Inhibitors of MAO have been used clinically as antihypertensive agents...
  60. MINOR DEPRESSION--PSYCHOSOCIAL TREATMENT IN PRIMARY CARE
    Charlotte Brown; Fiscal Year: 1999
    ..at four urban health centers in Pittsburgh, PA is proposed to examine the efficacy of problem-solving therapy (PST) provided by nurse clinicians for primary care patients with minor depression...
  61. Multifaceted Oncology Depression Program for Latinos
    Kathleen Ell; Fiscal Year: 2007
    ..MODP includes an initial choice of antidepressant medications or structured Problem Solving Treatment (PST), patient/family depression education, depression treatment maintenance and relapse prevention counseling, ..
  62. Aging and the cholinergic system on attention and timing
    Kevin Pang; Fiscal Year: 2007
    ..proposed behavioral studies with rats and humans involve similar versions of a simultaneous temporal processing (STP) task...
  63. Modification of tamoxifen effectiveness by gene polymorphisms and other drugs
    Timothy Lash; Fiscal Year: 2009
    ..Polymorphisms in the genes whose enzymes produce (GYP) or remove (SULT1A1 &UGT2B15) the active metabolites modify the metabolites'plasma concentrations...