STMN1

Summary

Gene Symbol: STMN1
Description: stathmin 1
Alias: C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin, leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18, phosphoprotein 19, phosphoprotein p19, prosolin, stathmin 1/oncoprotein 18, testicular tissue protein Li 189, transmembrane protein C1orf215
Species: human

Top Publications

  1. ncbi Stathmin: a relay phosphoprotein for multiple signal transduction?
    A Sobel
    INSERM U153 CNRS URA614, Paris, France
    Trends Biochem Sci 16:301-5. 1991
  2. ncbi Intracellular substrates for extracellular signaling. Characterization of a ubiquitous, neuron-enriched phosphoprotein (stathmin)
    A Sobel
    Institut National de la Santé de la Recherche Médicale U 153 Centre National de la Recherche Scientifique UA 614, Paris, France
    J Biol Chem 264:3765-72. 1989
  3. pmc Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis
    N Larsson
    Department for Cell and Molecular Biology, University of Umea, Sweden
    Mol Cell Biol 17:5530-9. 1997
  4. ncbi The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network
    O Gavet
    INSERM U440, IFM, 75005 Paris, France
    J Cell Sci 111:3333-46. 1998
  5. pmc Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin
    B Howell
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Mol Biol Cell 10:105-18. 1999
  6. ncbi Transforming properties of a Q18-->E mutation of the microtubule regulator Op18
    David E Misek
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 2:217-28. 2002
  7. ncbi Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
  8. ncbi p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
  9. pmc Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
    Y Kouzu
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Cancer 94:717-23. 2006
  10. ncbi Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53
    E Alli
    Department of Pharmacology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Oncogene 26:1003-12. 2007

Research Grants

  1. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
  2. MODELING VIRAL AND T LYMPHOCYTE DYNAMICS
    Alan S Perelson; Fiscal Year: 2011
  3. Alan S Perelson; Fiscal Year: 2016
  4. Carl Hirschie Johnson; Fiscal Year: 2014
  5. A Differential Dielectric Affinity Microsensor for Stable and Accurate Glucose Mo
    Qiao Lin; Fiscal Year: 2013
  6. High-affinity RNA targets of Survival Motor Neuron Protein
    Ravindra N Singh; Fiscal Year: 2013
  7. The Role of RNA Splicing Factors in Retinal Degeneration
    Michael Farkas; Fiscal Year: 2012
  8. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
  9. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot J Androphy; Fiscal Year: 2010
  10. PAUL GREGORY DONLIN-ASP; Fiscal Year: 2015

Detail Information

Publications467 found, 100 shown here

  1. ncbi Stathmin: a relay phosphoprotein for multiple signal transduction?
    A Sobel
    INSERM U153 CNRS URA614, Paris, France
    Trends Biochem Sci 16:301-5. 1991
    b>Stathmin is a ubiquitous, phylogenetically conserved protein present in the cytoplasm of cells in a variety of unphosphorylated and phosphorylated forms...
  2. ncbi Intracellular substrates for extracellular signaling. Characterization of a ubiquitous, neuron-enriched phosphoprotein (stathmin)
    A Sobel
    Institut National de la Santé de la Recherche Médicale U 153 Centre National de la Recherche Scientifique UA 614, Paris, France
    J Biol Chem 264:3765-72. 1989
    ..We propose to name this protein stathmin, from the greek "stathmos" (relay).
  3. pmc Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis
    N Larsson
    Department for Cell and Molecular Biology, University of Umea, Sweden
    Mol Cell Biol 17:5530-9. 1997
    b>Oncoprotein 18 (Op18; also termed p19, 19K, metablastin, stathmin, and prosolin) is a conserved protein that regulates microtubule (MT) dynamics...
  4. ncbi The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network
    O Gavet
    INSERM U440, IFM, 75005 Paris, France
    J Cell Sci 111:3333-46. 1998
    b>Stathmin is a small regulatory phosphoprotein integrating diverse intracellular signaling pathways...
  5. pmc Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin
    B Howell
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    Mol Biol Cell 10:105-18. 1999
    b>Oncoprotein 18/stathmin (Op18) has been identified recently as a protein that destabilizes microtubules, but the mechanism of destabilization is currently controversial...
  6. ncbi Transforming properties of a Q18-->E mutation of the microtubule regulator Op18
    David E Misek
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 2:217-28. 2002
    We have identified a somatic mutation in Op18 in a human esophageal adenocarcinoma...
  7. ncbi Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    We examined the expression of oncoprotein 18 (Op18) in 93 lung adenocarcinomas and 10 uninvolved lung samples using quantitative two-dimensional PAGE analysis with confirmation by mass spectrometry and two-dimensional Western blot ..
  8. ncbi p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
    ..This p27(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27(kip1) or downregulation of stathmin expression results in the inhibition of ..
  9. pmc Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
    Y Kouzu
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Cancer 94:717-23. 2006
    b>Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies...
  10. ncbi Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53
    E Alli
    Department of Pharmacology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Oncogene 26:1003-12. 2007
    ..We found that inhibition of stathmin, a microtubule regulator that can be transcriptionally repressed by wild-type p53, restored certain wild-type ..
  11. ncbi Structure and thermodynamics of the tubulin-stathmin interaction
    Michel O Steinmetz
    Biomolecular Research, Structural Biology, Paul Scherrer Institut, CH 5232 Villigen PSI, Switzerland
    J Struct Biol 158:137-47. 2007
    b>Oncoprotein 18/stathmin (stathmin) is a phosphorylation-controlled key regulator of microtubule dynamics...
  12. ncbi Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression
    Ritwik Ghosh
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2765, USA
    Prostate 67:1038-52. 2007
    ..We postulate that proteins, which regulate prostate growth also promote prostate cancer (PCa) progression...
  13. ncbi Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis
    Stephan Singer
    Institute of Pathology, University Hospital, University of Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg, Germany
    Hepatology 46:759-68. 2007
    The microtubule (MT)-destabilizing protein stathmin/Op18 has previously been described to be negatively regulated by p53 and to be highly expressed in several tumor entities...
  14. ncbi The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study
    Rastko Golouh
    Institute of Oncology, Ljubljana, Slovenia
    Breast Cancer Res Treat 110:317-26. 2008
    We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer...
  15. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
    ..Among the destabilizing proteins, stathmin is overexpressed in different human malignancies and has been recently linked to the regulation of cell motility...
  16. doi MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1
    Queenie W L Wong
    Department of Anatomical and Cellular Pathology at the Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, SAR Hong Kong, China
    Gastroenterology 135:257-69. 2008
    ..Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined...
  17. ncbi Regulation of melanocyte apoptosis by Stathmin 1 expression
    Yan Zhang
    Department of Biochemistry and Molecular Biology, Zhongshan Medical College, Sun Yat Sen University, Guangdong, People s Republic of China
    BMB Rep 41:765-70. 2008
    ..The role of Stathmin 1 as an important regulator of microtubule dynamics is well documented...
  18. doi Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients
    Wang Xi
    Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    J Cancer Res Clin Oncol 135:837-46. 2009
    b>Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and ..
  19. doi Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans
    Burkhard Brocke
    Institute of Psychology II, Dresden University of Technology, Dresden, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:243-51. 2010
    ..Recently it has been demonstrated that stathmin, a regulator of microtubule formation which affects long-term potentiation (LTP), controls learned and innate ..
  20. doi High expression of stathmin protein predicts a fulminant course in medulloblastoma
    Meng Fai Kuo
    Division of Neurosurgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan
    J Neurosurg Pediatr 4:74-80. 2009
    b>Stathmin, an important cytosolic phosphoprotein, is involved in cell proliferation and motility. This study was performed to elucidate the role of stathmin in the progression of medulloblastoma.
  21. pmc Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells
    T Y Jeon
    Department of Surgery, Pusan National University, Beomeo Ri, Mulgeum Eup, Yangsan, South Korea
    Br J Cancer 102:710-8. 2010
    ..The roles of stathmin1 in carcinogenesis of various cancers, including prostate and breast cancer, have been explored. However, its expression and roles in gastric cancer have not yet been described...
  22. ncbi Up-regulated expression of stathmin may be associated with hepatocarcinogenesis
    Lin Gan
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China
    Oncol Rep 23:1037-43. 2010
    b>Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and overexpressed in a variety of human malignancies...
  23. doi Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Umea, Sweden
    Exp Cell Res 316:2017-26. 2010
    Op18/stathmin (Op18) is a microtubule-destabilizing protein that is phosphorylation-inactivated during mitosis and its normal function is to govern tubulin subunit partitioning during interphase...
  24. doi Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer
    Ping Zheng
    Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People s Republic of China
    J Proteome Res 9:4897-905. 2010
    ..We identified 39 PRL-3 associated proteins based on proteomic strategy. Stathmin, a key oncoprotein, was proved to be a new PRL-3 associated protein...
  25. pmc Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules
    Nan Li
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Proc Natl Acad Sci U S A 108:12851-6. 2011
    ..Here we report that Siva1 interacts with stathmin, a microtubule destabilizer...
  26. doi Proteomic analysis of colorectal cancer metastasis: stathmin-1 revealed as a player in cancer cell migration and prognostic marker
    Hwee Tong Tan
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    J Proteome Res 11:1433-45. 2012
    ..Among these proteins, stathmin-1 (STMN1) was found to be highly up-regulated in E1 as compared to HCT-116 and was thus selected for further ..
  27. pmc Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer
    Wei Kang
    Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Sir Y K Pao Center for Cancer, The Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 7:e33919. 2012
    Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of cancers. This study was aimed to analyze its expression and biological functions in gastric cancer...
  28. doi Stathmin 1 is a potential novel oncogene in melanoma
    J Chen
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Oncogene 32:1330-7. 2013
    ..We suggested that stathmin 1 (STMN1) might be a target of miR-193b...
  29. pmc MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1
    Rui Wang
    Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, China
    PLoS ONE 7:e46173. 2012
    ..MicroRNA-101 (miR-101) expression is negatively associated with tumor growth and blood vessel formation in several solid epithelial cancers. However, the role of miR-101 in human breast cancer remains elusive...
  30. doi RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model
    F L Byrne
    Tumour Biology and Targeting Program, Children s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales, Australia
    Oncogene 33:882-90. 2014
    Metastatic neuroblastoma is an aggressive childhood cancer of neural crest origin. Stathmin, a microtubule destabilizing protein, is highly expressed in neuroblastoma although its functional role in this malignancy has not been addressed...
  31. doi High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition
    Elisabeth Wik
    Department of Obstetrics and Gynecology, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Clin Cancer Res 19:2331-41. 2013
    High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites...
  32. pmc Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
    Maura Sonego
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    EMBO Mol Med 5:707-22. 2013
    b>Stathmin is a p53-target gene, frequently overexpressed in late stages of human cancer progression. Type II High Grade Epithelial Ovarian Carcinomas (HG-EOC) represents the only clear exception to this observation...
  33. pmc Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
    Dominic Chi Hiung Ng
    Signal Transduction Laboratory, Institute of Molecular and Cell Biology, Singapore 138673, Republic of Singapore
    J Cell Biol 172:245-57. 2006
    ..In this study, we reveal an interaction between Stat3 and the microtubule (MT)-destabilizing protein stathmin. Stathmin did not overtly affect ligand-stimulated Stat3 activation...
  34. pmc Expression of transfected stathmin cDNA reveals novel phosphorylated forms associated with developmental and functional cell regulation
    V Doye
    INSERM U 153 CNRS URA 614, Paris, France
    Biochem J 287:549-54. 1992
    b>Stathmin is a ubiquitous, highly conserved phosphoprotein, which most likely acts as an intracellular relay integrating various transduction pathways triggered by extracellular signals...
  35. ncbi Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells
    Hui Zhong Zhang
    Department of Clinical Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 5:1457-61. 2006
    b>Stathmin gene overexpression has been shown to play an important role in maintenance of malignant phenotype in tumor cells, and the blocking efficacy and tumor specificity of this target has been concerned in clinical trails...
  36. pmc Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin
    Mikael E Sellin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 19:2897-906. 2008
    Op18/stathmin (Op18), a conserved microtubule-depolymerizing and tubulin heterodimer-binding protein, is a major interphase regulator of tubulin monomer-polymer partitioning in diverse cell types in which Op18 is abundant...
  37. ncbi [Expression of stathmin in esophageal squamous cell carcinoma and its biological significance]
    Feng Wang
    Department of Oncology, First Affiliated Hospital, Tumor Center, Zhengzhou University, Zhengzhou 450052, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1552-7. 2010
    To explore the expression of stathmin gene in esophageal squamous cell carcinoma (ESCC) and its correlation to oncogenesis of ESCC.
  38. doi Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer
    Jone Trovik
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 17:3368-77. 2011
    Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease...
  39. doi Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study
    Ann Christine Ehlis
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:291-302. 2011
    b>Stathmin 1 (STMN1) is a neuronal growth associated protein (NGAP) that is involved in microtubule dynamics and plays an important role in neurite outgrowth and synaptic plasticity...
  40. ncbi Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase
    U Marklund
    Department for Cell and Molecular Biology, University of Umea, Sweden
    J Biol Chem 268:15039-47. 1993
    b>Oncoprotein 18 (Op18) is an 18-19-kDa cytoplasmic phosphoprotein, of unknown function, that is frequently up-regulated in transformed cells...
  41. pmc Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
    J A Mitchell
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:1008-14. 1994
    ..The release of PGE2 induced by cytokines occurred after a lag period of more than 6 h.5...
  42. ncbi Enzymic pattern of preneoplastic and neoplastic lesions induced in the kidney of CBA mice by 1,2-dimethylhydrazine
    Y S Ahn
    , Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 22:415-22. 1994
    ..After a lag period of 2 yr kidneys were removed, and serial cryostat sections of the kidneys were histochemically analyzed for ..
  43. ncbi [Isotope angiocardiographic study of 30 cases of ventricular tachycardia with Fourier phase analysis]
    P Cosnay
    Service de cardiologie B, , Tours
    Arch Mal Coeur Vaiss 81:463-74. 1988
    ..At Fourier phase analysis all 17 VT of the right lag type originated in the left ventricle, arising from the apical septum (n = 7) or lateral segment (n = 2) in case of ..
  44. pmc Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP
    H Muhl
    Department of Pharmacology, Biocenter of the University of Basel, Switzerland
    Br J Pharmacol 112:1-8. 1994
    ..3. There was a lag period of about 8 h before a significantly enhanced secretion of nitrite could be detected upon exposure of cells ..
  45. ncbi Modulation of noninduced and phorbol ester-induced generation of superoxide anion by free liposomes and liposomes containing dexamethasone
    F Bellemare
    Centre de Recherche, , Ste-Foy, , Canada
    Immunopharmacol Immunotoxicol 19:121-34. 1997
    ..6 nmoles). The kinetics of cytochrome-c reduction revealed that decreased O-2 production resulted from an extended lag-time of release to almost 8 minutes with PMA induction and consequently led to the conclusion that liposomes ..
  46. ncbi Prenatal screening: when and for whom?
    N A Holtzman
    Department of Pediatrics, Health Policy and Management, and Epidemiology, Johns Hopkins University Medical Institutions, Baltimore, Maryland 21205
    J Gen Intern Med 5:S42-6. 1990
    ..During this lag phase, issues concerning the validity of the tests, the severity of the conditions for which screening is offered, ..
  47. ncbi [Hormonal contribution to short-term variability of blood pressure in a renovascular hypertension model]
    P Ponchon
    Laboratoire de Pharmacologie, CNRS URA 1482, , Paris
    Arch Mal Coeur Vaiss 88:1203-7. 1995
    ..Humoral stimuli could impinge on low frequency (LF) domain of blood pressure (BP) since the time lag to humoral systems activation is larger...
  48. ncbi Knowledge of travel medicine providers: analysis from a continuing education course
    T B Gardner
    The International Traveler s Medical Service, Division of Infectious Diseases, University of Connecticut Health Center, Farmington, Connecticut 06030 3212, USA
    J Travel Med 6:66-70. 1999
    ..completed a test determining knowledge in malaria chemoprophylaxis, traveler's diarrhea management, vaccines, jet lag, the returned traveler, and other areas. An identical test was given after completion of the course...
  49. ncbi The energetics of the common mole rat Cryptomys, a subterranean eusocial rodent from Zambia
    S Marhold
    Zoologisches Institut, , Frankfurt am Main
    J Comp Physiol B 164:636-45. 1995
    ..In 13-16 cm deep foraging tunnels, temperature fluctuations were higher following the above ground fluctuations with a time lag.(ABSTRACT TRUNCATED AT 400 WORDS)
  50. pmc Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways
    M J Smit
    Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Br J Pharmacol 107:448-55. 1992
    ..Video digital imaging revealed an increase in the lag time between stimulation and monitoring of the Ca2+ response and a reduced increase in [Ca2+]i after ..
  51. ncbi Examination of lesions in the urinary bladder and kidney of dogs induced by nefiracetam, a new nootropic agent
    Y Kashida
    Drug Safety Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Toxicol Pathol 24:549-57. 1996
    ..The lesions are thought to have a common etiopathogenesis and to be initiated by the epithelial damage with a time lag between expression of injury in the urinary bladder and the kidney.
  52. ncbi [Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome]
    Y Suzuki
    Department of Pediatrics, Osaka University Medical School
    No To Hattatsu 28:398-402. 1996
    ..or clonazepam was not predicted by clinical features (age of onset, seizure type, initial EEG finding or treatment lag)...
  53. ncbi Oxidation process of bovine heart ubiquinol-cytochrome c reductase as studied by stopped-flow rapid-scan spectrophotometry and simulations based on the mechanistic Q cycle model
    Y Orii
    Department of Public Health, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:17594-604. 1997
    ..in the presence of cytochrome c plus cytochrome c oxidase, the oxidation of b-type hemes accompanied an initial lag, apparently low potential heme bL was oxidized first, followed by high potential heme bH...
  54. ncbi High dose supplementation of RRR-alpha-tocopherol decreases cellular hemostasis but accelerates plasmatic coagulation in type 2 diabetes mellitus
    P Ferber
    German Diabetes Research Institute at the Heinrich-Heine University,
    Horm Metab Res 31:665-71. 1999
    ..RRR-alpha-tocopherol (vitamin E) per day for six months on serum levels, vitamin E load of LDL particles (HPLC), lag phase of LDL oxidation (Esterbauer's assay), platelet adhesion molecules, leukocyte-platelet coaggregation (flow ..
  55. ncbi Volume recovery, surface properties and membrane integrity of Lactobacillus delbrueckii subsp. bulgaricus dehydrated in the presence of trehalose or sucrose
    E E Tymczyszyn
    Laboratorio de Fisicoquimica de Membranas Lipidicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Appl Microbiol 103:2410-9. 2007
    ..The bacterial response upon rehydration was investigated by determining: (i) the lag time of the bacterial growing in rich media, (ii) the restoration of the surface properties and the cellular volume ..
  56. ncbi Evidence for cyclic GMP in the yeast Saccharomyces cerevisiae, and studies on its possible role in growth
    H Eckstein
    , Hamburg, Bundesrepublik Deutschland
    Z Naturforsch C 43:386-96. 1988
    ..The effects of 3-isobutyl-1-methylxanthine are reversible. Dibutyryl-cyclic GMP, and, after a pronounced lag, also dibutyryl-cyclic AMP, induce a premature cell division, too...
  57. ncbi Influence of cycloheximide on acute diabetogenic effects of S-carboxymethylated human growth hormone in obese (ob/ob) mice
    N A Adamafio
    Department of Physiology, University of Michigan Medical School, Ann Arbor
    Horm Metab Res 20:391-4. 1988
    ..The lag period seen in the manifestation of these diabetogenic effects of RCM-hGH is consistent with the time required for ..
  58. ncbi Influence of one- and two-stage biopsy-mastectomy procedures on psychologic adaptation of patients
    S Catania
    Divisione di Chirurgia Generale, Ospedale V. Buzzi, Milano, Italia
    Tumori 74:41-4. 1988
    ..for cancer, we compared drug consumption (analgesics and sedatives) in the postoperative period and the time lag between operation and the first spontaneous observation of surgical wound in two groups operated according to ..
  59. ncbi Seasonal and daily rhythms of body temperature in the European hamster (Cricetus cricetus) under semi-natural conditions
    F Wollnik
    Department of Biology, , Germany
    J Comp Physiol B 165:171-82. 1995
    ..rhythmicity was evident for body temperature apart from body temperature following ambient temperature with a time lag of 3-5 h. On average, hibernation bouts lasted 104.2 +/- 23.8 h with body temperature falling to 6.0 +/- 1...
  60. ncbi Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of Practice Committee, American Academy of Sleep Medicine
    A L Chesson
    Department of Neurology, Louisiana State University Medical Center, Shreveport, USA
    Sleep 22:641-60. 1999
    ..for delayed sleep phase syndrome (DSPS), advanced sleep phase syndrome (ASPS), non-24-hour sleep-wake syndrome, jet lag, shift work, dementia, and sleep complaints in the healthy elderly...
  61. ncbi [A case of Acanthamoeba keratitis after operation for cataract]
    M Takatsu
    Department of Clinical Laboratory Medicine, Nagoya University Hospital
    Kansenshogaku Zasshi 69:1159-61. 1995
    ..His visual acuity did not improve because of the lag of appropriate treatment...
  62. ncbi Subcutaneous sumatriptan in cluster headache: a time study of the effect on pain and autonomic symptoms
    J E Hardebo
    Department of Medical Cell Research, University of Lund, Sweden
    Headache 33:18-21. 1993
    ..After a time lag of 4-14 minutes (mean 7 minutes) pain dramatically dropped to zero within seconds to single minutes (mean 56 ..
  63. ncbi A case control study of multiple myeloma at four nuclear facilities
    S Wing
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Ann Epidemiol 10:144-53. 2000
    ..Dose response associations increased in magnitude with exposure age (from 40 to 50) and lag assumption (from 5 to 15 years), while a likelihood ratio goodness of fit test reached the highest value for ..
  64. ncbi Effect of travel and rest on performance of professional basketball players
    K Steenland
    National Institute for Occupational Safety and Health, Centers for Disease Control, Cincinnati, OH 45226, USA
    Sleep 20:366-9. 1997
    ..between games may be due to lack of time for physical recovery, rather than any effects of circadian rhythm (jet lag). We found few consistent effects of distance traveled or direction of travel...
  65. doi Modelling growth of Penicillium expansum and Aspergillus niger at constant and fluctuating temperature conditions
    Maria Gougouli
    Laboratory of Food Microbiology and Hygiene, Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Int J Food Microbiol 140:254-62. 2010
    ..3 to 35 degrees C and from 5 to 42.3 degrees C, respectively. The growth rate (mu) and (apparent) lag time (lambda) of the mycelium growth were modelled as a function of temperature using a Cardinal Model with ..
  66. ncbi Cervical sympathetic deficit in unilateral migraine headache
    P D Drummond
    Psychology Section, Murdoch University, Western Australia
    Headache 31:669-72. 1991
    ..Average pupil diameter was similar in migraine sufferers and controls. In patients with pupillary dilation lag on the usual side of headache, miosis persisted after 4% cocaine eyedrops...
  67. ncbi Early results with osseointegrated proximal interphalangeal joint prostheses
    K Moller
    Department of Hand Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    J Hand Surg Am 24:267-74. 1999
    ..after surgery, the average active range of motion was 56 degrees (20 degrees to 80 degrees) with an extension lag of 11 degrees (-5 degrees to 45 degrees), corresponding to an average arc of motion of from 11 degrees to 67 ..
  68. pmc Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors
    F Laszlo
    Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 111:1309-15. 1994
    ..2. Administration of LPS (3 mg kg-1, i.v.) increased ileal and colonic vascular injury after a lag period of 2 h, as determined by the leakage of radiolabelled albumin. 3. Administration of L-NAME (1-5 mg kg-1, s.c...
  69. ncbi [Utility and intricacy of molecular diagnosis of spinal muscular atrophy]
    T Fujii
    Department of Pediatrics, Shiga Medical Center for Children, Moriyama
    No To Hattatsu 31:505-10. 1999
    To diagnose spinal muscular atrophy (SMA), we examined the deletion of exons 7 and 8 of the survival motor neuron (SMN) gene and exon 5 of the neuronal apoptosis inhibitory protein (NAIP) gene in 7 patients from 6 unrelated families, ..
  70. ncbi [Value of the positive exercise test without angina (after myocardial infarct)]
    A Saint-Pierre
    , Lyon
    Arch Mal Coeur Vaiss 82:1701-7. 1989
    ..ET was performed without anti-ischaemic drugs. The mean time-lag between MI and ET was 51 +/- 55 months...
  71. ncbi The natural history of herniated nucleus pulposus with radiculopathy
    H Komori
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Japan
    Spine (Phila Pa 1976) 21:225-9. 1996
    ..Morphologic changes on magnetic resonance imaging mainly corresponded to clinical outcomes but tended to lag behind improvement of leg pain...
  72. ncbi A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag
    O M Buxton
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Sleep 23:915-27. 2000
    ..administration of a short-acting benzodiazepine hypnotic, which has proven effective in an animal model of jet lag, also facilitates adaptation of circadian rhythmicity and sleep-wake homeostasis in a human model of jet lag...
  73. ncbi [Properties of a hemolysin produced by group B streptococci]
    J Suzuki
    Department of Bioorganic Chemistry, College of Environmental Health Azabu University, Japan
    Kansenshogaku Zasshi 70:278-82. 1996
    ..on the membranes of target erythrocytes, followed by the gentle release of K+ and slow Hb release without lag time. Incontrast SLO released Hb as rapidly as K+...
  74. ncbi Insulin, but not estrogen, correlated with indexes of desaturase function in obese women
    L C Medeiros
    Department of Human Nutrition and Food Management, Ohio State University, Columbus, USA
    Horm Metab Res 27:235-8. 1995
    ..01) to aggregation as measured by impedance and negatively related to lag time (p < 0.05). Platelets of obese women aggregated more (p < 0...
  75. ncbi Phase lag of the intersegmental motion in flexion-extension of the lumbar and lumbosacral spine. An in vivo study
    M Kanayama
    Department of Orthopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Spine (Phila Pa 1976) 21:1416-22. 1996
    ..These intersegmental motion lags were much larger than the neutral zone in vitro, which implied the neutral zone in vivo should be different from the neutral zone in vitro...
  76. ncbi Is pregnancy smoking causal to testis cancer in sons? A hypothesis
    J Clemmesen
    Danish Cancer Registry, Copenhagen
    Acta Oncol 36:59-63. 1997
    ..testis cancer among men born 1939-1945, delays of increase are found for female bladder and lung with allowance for lag-times of 30 and 20 years respectively...
  77. ncbi Deletions in the SMN and NAIP genes in patients with spinal muscular atrophy in Croatia
    J Sertic
    Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine and Clinical Hospital, Croatia
    Coll Antropol 21:487-92. 1997
    Two genes, i.e. survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) have been mapped to the SMA region of chromosome 5q13. Both genes are frequently deleted or truncated in SMA patients...
  78. pmc Caffeine for the prevention of injuries and errors in shift workers
    Katharine Ker
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Room 280, North Courtyard, Keppel Street, London, UK, WC1E 7HT
    Cochrane Database Syst Rev 5:CD008508. 2010
    ..Jet lag and shift work disorder are circadian rhythm sleep disorders which result in sleepiness and can elevate injury risk...
  79. ncbi [Subjective stress factors and dyspnea in asthma patients over time]
    K Tetzlaff
    Schiffahrtmedizinisches Institut der Marine, Kiel
    Pneumologie 48:240-4. 1994
    ..or their coincidence with a time lag of one day. There were surprisingly few links between dyspnoea and mental stress/stressors in relation to time...
  80. ncbi Travel medicine advice to UK based international motor sport teams
    A Walters
    General Practitioner, Mayford House Surgery, East Road, Northallerton, DL6 1NP, United Kingdom
    J Travel Med 7:267-74. 2000
    ..by all team members; little or no problems with traveler's diarrhea; some tendencies to problems related to jet lag, but no real attempt to prevent the problem; and finally some attempt at skin protection against solar damage...
  81. ncbi Staged extensor tendon reconstruction in the finger
    B D Adams
    Department of Orthopaedic Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    J Hand Surg Am 22:833-7. 1997
    ..Active extension of the PIP joint was restored in all fingers; there was an average extension lag of 15 degrees. PIP joint flexion averaged 95 degrees...
  82. ncbi Salvage of a malpositioned anterior odontoid screw
    R F McLain
    Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Spine (Phila Pa 1976) 26:2381-4. 2001
    ..A large-diameter lag screw was then passed to the tip of the fragment...
  83. ncbi Influence of killer strains of Saccharomyces cerevisiae on wine fermentation
    F Perez
    Departamento de Microbiologia, Universidad de Extremadura, Badajoz, Spain
    Antonie Van Leeuwenhoek 79:393-9. 2001
    ..The addition of bentonite to the must avoided protracted fermentation and the suppression of sensitive strains; however, the addition of yeast dietary nutrients with yeast cell walls did not, although it decreased fermentation lag.
  84. ncbi Growth studies of plasmid bearing and plasmid cured Yersinia enterocolitica GER O:3 in the presence of cefsulodin, irgasan and novobiocin at 25 and 37 degrees C
    C M Logue
    The Great Plains Institute of Food Safety, Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, ND 58105, USA
    J Appl Microbiol 100:1299-306. 2006
    ....
  85. ncbi Lipid management: past, present, and future
    D J Betteridge
    Department of Medicine, Middlesex Hospital, London, UK
    Br J Clin Pract Suppl 77:1-10. 1996
    ..The UK continues to lag behind in this area...
  86. ncbi Morphological and electrophysiological properties of a novel in vitro preparation: the electrosensory lateral line lobe brain slice
    W B Mathieson
    Department of Anatomy, Faculty of Health Sciences, University of Ottawa, Canada
    J Comp Physiol A 163:489-506. 1988
    ..The majority of pyramidal cells respond to depolarizing current pulses with an initial lag in spike firing followed by a non-accommodating, higher frequency spike train...
  87. pmc Thick filament movement and isometric tension in activated skeletal muscle
    R Horowits
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    Biophys J 54:165-71. 1988
    ..The calculated time course of thick filament movement exhibits a lag phase, during which the velocity and extent of movement are extremely small...
  88. ncbi [Properties of a hemolysin produced by group C streptococci isolated from hemolytic streptococcal infection in formosan squirrels]
    J Suzuki
    Department of Bioorganic Chemistry, Azabu University
    Kansenshogaku Zasshi 69:327-32. 1995
    ..membranes of target erythrocytes, followed by the rapid released of K+ and slow Hb release after a relatively long lag time...
  89. ncbi Lunotriquetral arthrodesis. A controversial procedure
    G R Sennwald
    Chirurgie St Leonhard, St Gallen, Switzerland
    J Hand Surg Br 20:755-60. 1995
    ..This emphasizes the importance of correct positioning of the triquetrum, which seems hard to achieve with two AO lag screws...
  90. ncbi [Serial measurement of anti-interleukin-8 IgG autoantibody in cerebrospinal fluid of infants with bacterial meningitis]
    J Takasaki
    Department of Pediatrics, Saitama Medical Center, Saitama Medical School
    Kansenshogaku Zasshi 74:811-5. 2000
    ..The time lag between the decrease of IL-8 and anti-IL-8 IgG autoantibody demonstrated in the present study could be used to ..
  91. ncbi [Original survey and analysis method of the vestibulo-ocular transfer using the microcomputer. Contribution to the diagnosis of vestibular pathology]
    R Lavalle

    Acta Otorhinolaryngol Belg 43:435-52. 1989
    ..The mean phase lag of 180 degrees, from 0.1 Hz to 2...
  92. ncbi Nuclear magnetic resonance measurement of intracellular sodium in the perfused normotensive and spontaneously hypertensive rat heart
    L A Jelicks
    Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461
    Am J Hypertens 7:429-35. 1994
    ..These results support the existence of sodium pump lag in the rat heart perfused at physiologic Ca2+ concentration and suggest that the hypertensive rat heart has adapted ..
  93. pmc SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta
    Usha Narayanan
    Department of Genetics, Center for Human Genetics and Program in Cell Biology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA
    Hum Mol Genet 11:1785-95. 2002
    The survival of motor neuron (SMN) protein is mutated in patients with spinal muscular atrophy (SMA). SMN is part of a multiprotein complex required for biogenesis of the Sm class of small nuclear ribonucleoproteins (snRNPs)...
  94. ncbi [REVEIL Trial: Study validity, information and logistics. Preliminary results. Quality measures]
    P Demolis
    Unite de recherche clinique, Hopital Bicetre, Le Kremlin Bicetre
    Arch Mal Coeur Vaiss 94:901-5. 2001
    ..included patients, 362 (85%) gave analyzable data, the difference being explained by refusals (n = 39) and by the lag between inclusion and completion. Mean age was 55.2 (range 20 to 90)...
  95. doi Jet lag: therapeutic use of melatonin and possible application of melatonin analogs
    Venkataramanujan Srinivasan
    Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Kelantan Malaysia
    Travel Med Infect Dis 6:17-28. 2008
    ..These multiple time zone flights produce a constellation of symptoms known as jet lag. Familiar to almost every intercontinental traveler is the experience of fatigue upon arrival in a new time zone, ..
  96. ncbi Gene deletion patterns in spinal muscular atrophy patients with different clinical phenotypes
    M Z Haider
    Paediatrics Department, Faculty of Medicine, Kuwait University, PO Box 24923, Safat 13110, Kuwait
    J Biomed Sci 8:191-6. 2001
    ..We have assayed deletions in two candidate genes, the survival motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) genes, in 108 samples, of which 46 were from SMA patients, and 62 ..
  97. ncbi Correlation between deletion patterns of SMN and NAIP genes and the clinical features of spinal muscular atrophy in Indian patients
    Rashna S Dastur
    Department of Neuropathology and Applied Biology, Medical Research Centre, Bombay Hospital, Mumbai, India
    Neurol India 54:255-9. 2006
    ..Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder involving degeneration of anterior horn cells of spinal cord resulting in progressive muscle weakness and atrophy...
  98. ncbi Long-term effects of adjuvant chemotherapy in breast cancer
    J F Forbes
    Department of Surgical Oncology, University of Newcastle, Mater Misericordiae Hospital, Waratah, Australia
    Acta Oncol 31:243-50. 1992
    Late effects of adjuvant chemotherapy (ACT) may include second malignant neoplasms (SMN), cardiotoxicity and ovarian suppression. Effects on the biology of residual tumour may be important in protocol design...
  99. ncbi Age-related differences in recovery from simulated jet lag
    M L Moline
    Institute of Chronobiology, New York Hospital-Cornell Medical Center, White Plains
    Sleep 15:28-40. 1992
    ..The compensatory response to sleep deprivation may also be less robust in middle-aged individuals traveling eastbound...
  100. ncbi Biceps-to-triceps transfer in tetraplegic patients: report of the medial routing technique and follow-up of three cases
    J E Kuz
    Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, USA
    J Hand Surg Am 24:161-72. 1999
    ..No patient achieved less than grade 4 extension strength; none had an extension lag greater than 8 degrees...
  101. ncbi Free and island vascularized joint transfer for proximal interphalangeal reconstruction: a series of 27 cases
    G Foucher
    SOS Main Strasbourg, France
    J Hand Surg Am 19:8-16. 1994
    ..period of 37 months, mean active range of motion of heterodigital island joint was 56 degrees (mean extensor lag, 21 degrees), excepting one failure ending with an arthrodesis...

Research Grants84

  1. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
    ..limitations of the interstitial (subcutaneous) space where they are currently implanted: 1) there is substantial lag time between changes in blood glucose and changes in interstitial glucose, 2) there is substantial variability in ..
  2. MODELING VIRAL AND T LYMPHOCYTE DYNAMICS
    Alan S Perelson; Fiscal Year: 2011
    ..Understanding the basis of pathogenesis and the development of potent antiviral therapies for these viruses lag behind our advances in HIV...
  3. Alan S Perelson; Fiscal Year: 2016
    ..Understanding the basis of pathogenesis and the development of potent antiviral therapies for these viruses lag behind our advances in HIV...
  4. Carl Hirschie Johnson; Fiscal Year: 2014
    ..e., by shiftwork or "jet-lag")...
  5. A Differential Dielectric Affinity Microsensor for Stable and Accurate Glucose Mo
    Qiao Lin; Fiscal Year: 2013
    ..by limitations such as low accuracy (especially at hypoglycemic glucose concentrations), poor stability, and long lag times...
  6. High-affinity RNA targets of Survival Motor Neuron Protein
    Ravindra N Singh; Fiscal Year: 2013
    ..Most cases of SMA are associated with the low levels of SMN protein due to deletion or mutation of Survival Motor Neuron 1 (SMN1) gene...
  7. The Role of RNA Splicing Factors in Retinal Degeneration
    Michael Farkas; Fiscal Year: 2012
    ..the neurologic disorder spinal muscular atrophy (SMA), which is caused by mutations in the survival motor neurons (SMN) gene...
  8. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    ..Although decreased levels of the survival motor neuron (SMN) protein cause SMA and inversely correlate with disease severity in both human patients and mouse model, the ..
  9. Testing Compounds that Increase SMN levels for Efficacy in Mouse Models of SMA
    Elliot J Androphy; Fiscal Year: 2010
    ..SMA results from insufficient levels of the survival motor neuron (SMN) protein, usually due to homozygous deletion of the SMN1 gene...
  10. PAUL GREGORY DONLIN-ASP; Fiscal Year: 2015
    ..SMA results from either a deletion or mutation in the SMN1 gene, encoding the survival of motor neuron protein (SMN)...
  11. Small Oligonucleotides As Therapeutic Agents Of Spinal Muscular Atrophy
    Ravindra N Singh; Fiscal Year: 2012
    ..Most commonly, SMA results from the reduced levels of full-length SMN protein (SMN) in motor neurons and spinal chord due to the loss of functional Survival Motor Neuron (SMN1) alleles...
  12. LAXMAN DASS GANGWANI; Fiscal Year: 2014
    ..The defect in nuclear accumulation of SMN is the biochemical defect in SMA...
  13. Role of Stasimon Dysfunction in Spinal Muscular Atrophy
    Livio Pellizzoni; Fiscal Year: 2013
    ..Although it is well established that reduced levels of the survival motor neuron (SMN) protein due to homozygous mutations in the SMN1 gene cause SMA, the molecular basis of motor neuron dysfunction ..
  14. Cooperative lead development program for treatment of spinal muscular atrophy
    Elliot J Androphy; Fiscal Year: 2012
    ..SMA is caused by insufficient levels of the survival motor neuron (SMN) protein, usually from homozygous mutation of the SMN1 gene...
  15. Brian K Kaspar; Fiscal Year: 2015
    ..for gene therapy because it is a single gene defect that results in low amounts of the survival motor neuron (SMN) protein (hypomorph) versus a total deficiency3...
  16. Craig L Bennett; Fiscal Year: 2014
    ..As it turns out, altered RNA processing in neurodegeneration is well established including loss of SMN in spinal muscular atrophy (SMA) and loss of FMRP in fragile-X mental retardation...
  17. SANIYA FAYZULLINA; Fiscal Year: 2014
    ..It is caused by mutations in the Survival of Motor Neuron (SMN) gene and is the second most common genetic cause of childhood mortality [6]...
  18. Livio Pellizzoni; Fiscal Year: 2014
    ..The study of the survival motor neuron (SMN) protein provides a unique opportunity to address the basic biology of splicing regulation and the role of RNA ..
  19. Judith A Steen; Fiscal Year: 2014
    TITLE: Regulation of SMN stability and identification of its downstream targets SUMMARY Spinal Muscular Atrophy (SMA), a disease caused by the mutations of Survival Motor Neuron 1 (SMN1) gene, is the most common genetic cause of infant ..
  20. Motoneuron-selective Rescue of SMA Model Mice
    Mendell Rimer; Fiscal Year: 2012
    ..Mutations in the survival of motoneuron 1 (SMN1) gene account for SMA. All cells in the body produce SMN and its major function is in spliceosome assembly...
  21. Motor neuron generation from SMA patient-derived induced pluripotent stem cells
    Allison D Ebert; Fiscal Year: 2010
    ..SMA is caused by a homozygous loss of the survival motor neuron-1 (SMN) gene leading to the progressive loss of alpha-motor neurons in the spinal cord causing atrophy of trunk and limb ..
  22. Novel CNS Target for Sleep-Wake and Psychiatric Disorders
    SCOTT MCNEAR THACHER; Fiscal Year: 2010
    ..therapeutic potential in circadian rhythm sleep disorders (CRSDs) such as delayed sleep phase disorder (DSPD), jet lag, shift work sleep disorder, and dementia, where disruption of sleep-wake patterns is of major economic and clinical ..
  23. Arthur H M Burghes; Fiscal Year: 2014
    ..As in many neurogenetic disorders, the mutated protein SMN is ubiquitously expressed, yet only a particular type of neuron is affected...
  24. Delivery of therapeutic genes in motor neuron disease
    Don W Cleveland; Fiscal Year: 2010
    ..We will specifically focus on the two major motor neuron disorders, Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). The delivery of SMN in SMA will have a major benefit.
  25. Animal models to examine role of ZPR1 protein complexes
    LAXMAN DASS GANGWANI; Fiscal Year: 2010
    ..ZPR1 interacts with survival motor neuron (SMN) and eukaryotic translation elongation factor 1A (eEF1A) proteins...
  26. GEORGE ZACHARIAS MENTIS; Fiscal Year: 2016
    ..are particularly affected by the disease and whether this is due to motor neuron dysfunction or intrinsic to SMN deficiency in these neuronal circuits...
  27. Synapse Loss in Spinal Muscular Atrophy
    Chien Ping Ko; Fiscal Year: 2010
    ..In this application, type II SMA-like mouse models (SMN 7 SMA and SMN-Hung SMA) will be used to test a novel concept that reduction of synaptic inputs to motoneurons in ..
  28. CATHERINE DOMINGUEZ; Fiscal Year: 2015
    ..SMA is caused by low levels of survival motor neuron (SMN) protein. SMN is encoded by two genes, SMN1 and SMN2...
  29. JESSICA MARIE FERRELL; Fiscal Year: 2014
    ..Diabetes, obesity, and metabolic syndrome are associated with perturbations in circadian rhythms due to jet lag, shift work, and sleep deprivation, while altered diet composition can affect peripheral rhythmic gene expression...
  30. A Gregory Matera; Fiscal Year: 2015
    ..Assembly into stable RNP particles is thought to be mediated by the Survival Motor Neuron (SMN) protein complex, which loads Sm proteins onto snRNAs, forming a heptameric ring structure called the Sm-core...
  31. Tetracycline derivatives as SMN2 mRNA splicing modifiers for treatment of SMA.
    S Ken Tanaka; Fiscal Year: 2013
    ..is the result of the homozygous mutation or deletion of the SMN1 (survival motor neuron-1) gene which encodes the SMN protein (SMNp) which is necessary for the survival of motor neurons...
  32. Peter Olofsson; Fiscal Year: 2014
    ..to cancer therapy;(2) telomere dynamics, relevant to processes of aging and also to cancer therapy;(3) bacterial lag phase estimation, relevant to food microbiology;and three projects relevant to degenerative genetic disease: (4) ..
  33. Christine E Beattie; Fiscal Year: 2014
    ..The survival motor neuron (SMN) gene is the genetic cause of SMA and has a clearly defined role in assembling RNAs and proteins needed for mRNA ..
  34. The role of mir-17~92 cluster in motor neuron degeneration
    Hynek Wichterle; Fiscal Year: 2013
    ..sensitive to mutations affecting broadly expressed genes, such as SOD1 in amyotrophic lateral sclerosis or SMN in spinal muscular atrophy...
  35. Alpha-synuclein downregulation in Spinal Muscular Atrophy
    Graham C Parker; Fiscal Year: 2012
    ..Alpha motor neuron death in spinal muscular atrophy (SMA) is caused by low levels of survival motor neuron (SMN) protein. SMN interacts with proteins known to participate in RNA processing, apoptosis and axonal transport...
  36. DANIEL BATTLE; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Gemin5 is the RNA-binding protein of the Survival of Motor Neurons (SMN) complex...
  37. Justin C Lee; Fiscal Year: 2015
    ..Moreover, all patients with SMA have homozygous loss of function of the survival motor neuron (SMN) gene. Mouse models with loss of SMN are therefore representative of the disease in all patients...
  38. Muscle and neuromuscular junctions in spinal muscular atrophy
    CHARLOTTE JANE SUMNER; Fiscal Year: 2013
    ..SMA is caused by deficiency of the survival motor neuron (SMN) protein...
  39. Disease Pluripotent Stem (iPS) Cells
    Su Chun Zhang; Fiscal Year: 2010
    ..atrophy (SMA) is a progressive neurodegenerative disease caused by mutations in the "survival of motor neuron (SMN)" gene, leading to spinal motor neuron degeneration and muscular atrophy...
  40. Electrophysiological phenotypes in a Drosophila model of SMA
    Subhabrata Sanyal; Fiscal Year: 2012
    ..centromeric homolog SMN2 which is similar to SMN1 but that, due to splicing errors, makes very little functional SMN protein...
  41. Michelle L Hastings; Fiscal Year: 2014
    ..Humans have a second gene, SMN2, which is nearly identical to SMN1. Both SMN1 and SMN2 code for SMN protein. However, the majority of SMN2 mRNA transcripts splice out exon 7...
  42. Christine J DiDonato; Fiscal Year: 2016
    ..This results in low SMN levels which are not enough to sustain motor neurons and results in a varying clinical presentation...
  43. The Identification and Manipulation of RNA Splicing Factor Regulators in Spinal M
    MALLORY ANN HAVENS; Fiscal Year: 2013
    ..The disease results from homozygous deletion of the SMN1 gene, which codes for the survival of motor neuron (SMN) protein...
  44. Molecular Etiology of Spinal Muscular Atrophy
    A Gregory Matera; Fiscal Year: 2013
    ..Patients with SMA typically die early in childhood. Reduced levels of SMN protein cause the disease;complete loss of SMN expression results in prenatal lethality...
  45. Testing Therapies in a New Mild SMA Mouse: A Model for Type II/III Patients
    Cathleen M Lutz; Fiscal Year: 2013
    ..in delivering therapies, we have designed a study to evaluate the efficacy of increasing survival motor neuron (SMN) levels throughout development using a new preclinical SMA mouse model, called the Burgheron mouse...
  46. Nuclear bodies and ribonucleoprotein biogenesis
    Michael D Hebert; Fiscal Year: 2012
    ..Gems contain the Survival of Motor Neuron (SMN) protein, which is mutated in most patients with the neurodegenerative disorder Spinal Muscular Atrophy...
  47. Changwei Liu; Fiscal Year: 2014
    ..provided by applicant): Mutations or deletions in the survival of motor neuron 1 (SMN1) gene that decreases the SMN protein expression result in spinal muscular atrophy (SMA), a genetically inherited disease that causes progressive ..
  48. Elliot J Androphy; Fiscal Year: 2016
    We discovered that the SMN protein binds to alpha-COP, the largest constituent of the heptameric COPI vesicle...
  49. Zhongwei Du; Fiscal Year: 2014
    ..It is caused by mutations or deletions in the gene encoding the survival motor neuron protein (SMN)...
  50. Umrao Monani; Fiscal Year: 2016
    ..caused by homozygous mutations in the Survival of Motor Neuron 1 (SMN1) gene that lead to a deficiency of the SMN protein. Residual protein is expressed from SMN2, a partially functional homologue of the SMN1 gene...
  51. Ravindra N Singh; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Humans have two copies of Survival of Motor Neuron (SMN) gene, SMN1 and SMN2. Loss of SMN1 leads to spinal muscular atrophy (SMA), a debilitating disease of infants and children...
  52. 15th Annual International Spinal Muscular Atrophy Research Group Meeting
    Jill Jarecki; Fiscal Year: 2011
    ..The molecular basis of the disease is a deficiency in production of a specific protein - Survival of Motor Neuron (SMN) protein...
  53. SARAH R TISDALE; Fiscal Year: 2014
    ..is caused by reduced levels of the evolutionarily conserved and ubiquitously expressed survival of motor neuron (SMN) protein...
  54. 14th Annual International Spinal Muscular Atrophy Research Group Meeting
    Jill Jarecki; Fiscal Year: 2010
    ..The molecular basis of the disease is a deficiency in production of a specific protein - Survival of Motor Neuron (SMN) protein...
  55. Sensitization of Human Circadian Responses to Light
    Charles A Czeisler; Fiscal Year: 2013
    ..rhythm disorders, including delayed and advanced sleep phase disorders, shift work sleep disorder, and jet lag, and they may also have relevance for the use of light to treat seasonal affective disorder...
  56. Sleep Length and Circadian Regulation in Humans
    HELEN JULIA BURGESS; Fiscal Year: 2012
    ..Millions of Americans suffer from circadian rhythm sleep disorders, which include shift work sleep disorder, jet lag, delayed sleep phase syndrome and possibly winter depression...
  57. David L Van Vactor; Fiscal Year: 2014
    ..However, the identity and function of relevant SMN target genes and the precise molecular role of SMN at the NMJ remain largely a mystery...
  58. Determinants that regulate splicing of SMN
    Christian L Lorson; Fiscal Year: 2012
    ..The alternatively spliced form lacks exon 7, which is normally the final coding exon, and is referred to as SMN exon 7...
  59. CASEIN KINASE I AND THE REGULATION OF CIRCADIAN RHYTHM
    Donald E Ayer; Fiscal Year: 2010
    ..Pharmacological manipulation of rhythms could mitigate stress from jet lag, shift work, and perhaps even seasonal affective disorder.
  60. 16th Annual International Spinal Muscular Atrophy Research Group Meeting
    Jill Jarecki; Fiscal Year: 2012
    ..The molecular basis of the disease is a deficiency in production of a specific protein - Survival of Motor Neuron (SMN) protein...
  61. Efficacy of melatonin treatment in a phase advance model of insomnia
    Jeanne F Duffy; Fiscal Year: 2013
    ..reported to be an effective treatment for circadian rhythm sleep disorders, including shift work dyssomnia, jet-lag, delayed sleep phase syndrome, and sleep disruption suffered by many blind individuals...
  62. Stephen J Kolb; Fiscal Year: 2014
    ..SMA therapies that increase SMN levels in motor neurons have been most effective when delivered in the immediate postnatal period of development ..
  63. 17th Annual International Spinal Muscular Atrophy Research Group Meeting
    Jill Jarecki; Fiscal Year: 2013
    ..The molecular basis of the disease is a deficiency in production of a specific protein - Survival of Motor Neuron (SMN) protein...
  64. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..The lag in progress for rescue of rod photoreceptor diseases is due to the absence of efficacious gene transfer vectors for ..
  65. Discovery of Selective MT1 Melatonin Receptor Ligands for Sleep Disorders
    Margarita L Dubocovich; Fiscal Year: 2010
    ..and circadian sleep disorders, such as those observed in delayed sleep phase syndrome, blind individuals, and jet lag. PUBLIC HEALTH RELEVANCE: Sleep disorders due to stress, illness, chronic pain, psychiatric conditions, and poor ..
  66. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..PWV is usually quantified from the time lag of the systolic pressure wave between a location in the carotid artery and a point in the femoral artery using ..
  67. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2005
    ..New information regarding the nature and function of the SMN protein and the availability of new pharmacologic agents now make it possible to consider clinical trials in this ..
  68. Novel Gene Delivery Development for Spinal Muscular Atrophy
    Brian Kaspar; Fiscal Year: 2009
    ..SMA is caused by a reduction in the expression of the survival motor neuron (SMN) protein...
  69. microRNA biogenesis and function in spinal muscular atrophy
    Zissimos Mourelatos; Fiscal Year: 2007
    ..SMA is caused by deletions or loss of function mutations of the Survival of Motor Neurons (SMN) gene...
  70. The Mouse SNM Gene: Potential Role in Modeling Spinal Muscular Atrophy
    JORDAN GLADMAN; Fiscal Year: 2009
    ..We hypothesize that the introduction of the human SMN2 exon 7 point mutation in the mouse SMN gene will allow for exon 7 skipping in the mouse and model the SMA phenotype...
  71. Iron Delivery Via hemodialysate in ESRD
    Ajay Gupta; Fiscal Year: 2005
    ..in=30) with no evidence of iron overload (transferrin saturation or TSAT< 40 percent, and ferritin < 800 lag/L), who have needed intravenous iron in the previous 2 months will be enrolled...
  72. Human circadian sensitivity to very short light pulses
    Elizabeth B Klerman; Fiscal Year: 2010
    ..pacemaker or of its normal phase relationship with local time, such as with night or rotating work shifts or jet lag, is associated with illness, errors and accidents...
  73. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    John Blake; Fiscal Year: 2005
    ..decades the State of Alaska has had surprisingly limited participation in biomedical research and we consistently lag behind the other states and territories in NIH funding...
  74. METABLASTIN AND THE CONTROL OF CELL DIVISION
    ULRICH SCHUBART; Fiscal Year: 1999
    This proposal is to study the role of metablastin, a highly conserved cytosolic protein involved in signal transduction, in the control of mammalian cell division...
  75. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..However, a lag time of about 2-3 weeks exists from the onset of medication until the first signs of improvement appear...
  76. Metabolic-Inflammatory Systems in Irreversible Shock
    Juan Carlos Puyana; Fiscal Year: 2007
    ..Depending on the severity of the hemorrhage and the time lag between injury and hemostasis, some patients with hemorrhagic shock may enter into irreversible circulatory ..
  77. CARBOHYDRATE BINDING PROTEIN 35
    John Wang; Fiscal Year: 2006
    ..Gemin4 is one component of a macromolecular complex, the SMN (Survival of Motor Neuron) complex, which has been visualized in subnuclear structures designated as gems...
  78. Basic mechanisms of antidepressant augmentation
    Michael Newman; Fiscal Year: 2003
    ..The first is that there is almost always a lag period before they are effective, and the second that 20-30 percent of depressed patients do not respond adequately ..