STIM1

Summary

Gene Symbol: STIM1
Description: stromal interaction molecule 1
Alias: D11S4896E, GOK, IMD10, STRMK, TAM, TAM1, stromal interaction molecule 1
Species: human

Top Publications

  1. pmc Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
    Yih Fung Chen
    Department of Pharmacology, National Cheng Kung University, Tainan 70101, Taiwan
    Proc Natl Acad Sci U S A 108:15225-30. 2011
  2. ncbi STIM1: a novel phosphoprotein located at the cell surface
    S S Manji
    Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Biochim Biophys Acta 1481:147-55. 2000
  3. pmc STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
    Rajender K Motiani
    The College of Nanoscale Science and Engineering CNSE, University at Albany, State University of New York, 257 Fuller Rd, Albany, NY 12203, USA
    Pflugers Arch 465:1249-60. 2013
  4. pmc HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
    J Robert Chang
    Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:41125-34. 2011
  5. pmc STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
    Weizhong Zeng
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 32:439-48. 2008
  6. pmc STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity
    Capucine Picard
    Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris
    N Engl J Med 360:1971-80. 2009
  7. doi Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation
    Charbel El Boustany
    Institut National de Santé et recherche Médicale INSERM, U800, IFR143, Université Sciences et Technologies Lille 1, F 59655, Villeneuve d Ascq, France
    Hepatology 47:2068-77. 2008
  8. pmc Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate
    Megumi Yamashita
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:9429-42. 2011
  9. doi The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2+ channel subunits Orai1 and TRPC1
    Carmen Galan
    Department of Physiology Cellular Physiology Research Group, University of Extremadura, 10071 Caceres, Spain
    Biochem Pharmacol 82:400-10. 2011
  10. pmc STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
    Peter B Stathopulos
    University Health Network and Department of Medical Biophysics, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University of Toronto, Room 4 804, MaRS TMDT, 101 College Street, Toronto, Ontario, Canada M5G 1L7
    Nat Commun 4:2963. 2013

Research Grants

  1. Clifford A Lowell; Fiscal Year: 2016
  2. The Role of Stanniocalcin 2 in Calcium Homeostasis and Neuronal Pathology
    WILLIAM ABEL ZEIGER; Fiscal Year: 2012
  3. David A Holowka; Fiscal Year: 2014
  4. Suzette Farber-Katz; Fiscal Year: 2014
  5. Iain A Drummond; Fiscal Year: 2014
  6. Mohamed Trebak; Fiscal Year: 2014
  7. Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum
    MICHAEL WILLIAM ROE; Fiscal Year: 2010
  8. Brij B Singh; Fiscal Year: 2016
  9. Tobias Meyer; Fiscal Year: 2016
  10. Store Operated Calcium Channels Function in Vascular Smooth Muscle
    Salvatore Mancarella; Fiscal Year: 2012

Patents

  1. T cell activating gene

Detail Information

Publications185 found, 100 shown here

  1. pmc Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
    Yih Fung Chen
    Department of Pharmacology, National Cheng Kung University, Tainan 70101, Taiwan
    Proc Natl Acad Sci U S A 108:15225-30. 2011
    ..Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca(2+) sensor that triggers SOCE activation...
  2. ncbi STIM1: a novel phosphoprotein located at the cell surface
    S S Manji
    Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Biochim Biophys Acta 1481:147-55. 2000
    b>STIM1 is a novel candidate growth suppressor gene mapping to the human chromosome region 11p15.5 that is associated with several malignancies...
  3. pmc STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
    Rajender K Motiani
    The College of Nanoscale Science and Engineering CNSE, University at Albany, State University of New York, 257 Fuller Rd, Albany, NY 12203, USA
    Pflugers Arch 465:1249-60. 2013
    The Ca(2+) sensor stromal interacting molecule 1 (STIM1) and the Ca(2+) channel Orai1 mediate the ubiquitous store-operated Ca(2+) entry (SOCE) pathway activated by depletion of internal Ca(2+) stores and mediated through the highly Ca(2+..
  4. pmc HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
    J Robert Chang
    Department of Neurology, Molecular Studies of Neurodegenerative Diseases Laboratory, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:41125-34. 2011
    ..Therefore, we conclude that deregulation of neuronal functions by HIV-1 Tat protein is miRNA-dependent...
  5. pmc STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
    Weizhong Zeng
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 32:439-48. 2008
    ..Although both are gated by STIM1, it is not known how STIM1 gates the channels and whether STIM1 gates the TRPCs and Orais by the same mechanism...
  6. pmc STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity
    Capucine Picard
    Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris
    N Engl J Med 360:1971-80. 2009
    ..b>Stromal interaction molecule 1 (STIM1) in the endoplasmic reticulum activates ORAI1-CRAC channels...
  7. doi Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation
    Charbel El Boustany
    Institut National de Santé et recherche Médicale INSERM, U800, IFR143, Université Sciences et Technologies Lille 1, F 59655, Villeneuve d Ascq, France
    Hepatology 47:2068-77. 2008
    ..Huh-7 and HepG2 cells express transient receptor potential canonical 1 (TRPC1) and TRPC6, as well as STIM1 and Orai1, and these 4 channels are the most likely candidates to account for the SOCE in these cells...
  8. pmc Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate
    Megumi Yamashita
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:9429-42. 2011
    ..of intracellular Ca(2+) stores involves physical interactions between the endoplasmic reticulum Ca(2+) sensor, STIM1, and the channels composed of Orai subunits...
  9. doi The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2+ channel subunits Orai1 and TRPC1
    Carmen Galan
    Department of Physiology Cellular Physiology Research Group, University of Extremadura, 10071 Caceres, Spain
    Biochem Pharmacol 82:400-10. 2011
    ..Recent studies favour a conformational coupling mechanism between the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and Ca(2+) permeable channels in the plasma membrane to explain SOCE...
  10. pmc STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
    Peter B Stathopulos
    University Health Network and Department of Medical Biophysics, Campbell Family Cancer Research Institute, Ontario Cancer Institute, University of Toronto, Room 4 804, MaRS TMDT, 101 College Street, Toronto, Ontario, Canada M5G 1L7
    Nat Commun 4:2963. 2013
    Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE)...
  11. pmc Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
    Jason C Mercer
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 281:24979-90. 2006
    ..Recent findings have implicated two proteins, Stim1 and Orai1, as having essential roles in store-operated Ca(2+) entry across the plasma membrane...
  12. doi Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics
    Peter B Stathopulos
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
    J Biol Chem 284:728-32. 2009
    ..Despite a high sequence similarity (>65%) and analogous sequence-based domain architectures, STIM1 and STIM2 differentially influence these phenomena...
  13. pmc Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8
    Agnes C L Martin
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    Mol Pharmacol 75:830-42. 2009
    ..through the plasma membrane as a result of Ca(2+) store depletion, is mediated by stromal interacting molecule 1 (STIM1), a sensor of intracellular Ca(2+) store content, and the pore-forming component Orai1...
  14. pmc Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58201, USA
    Proc Natl Acad Sci U S A 106:20087-92. 2009
    Store-operated Ca(2+) entry (SOCE) is activated by redistribution of STIM1 into puncta in discrete ER-plasma membrane junctional regions where it interacts with and activates store-operated channels (SOCs)...
  15. pmc Location and function of STIM1 in the activation of Ca2+ entry signals
    Thamara Hewavitharana
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 283:26252-62. 2008
    ..b>STIM1 senses decreased ER luminal Ca(2+) through its EF-hand Ca(2+)-binding motif and aggregates in near-plasma membrane ..
  16. pmc STIM1, an essential and conserved component of store-operated Ca2+ channel function
    Jack Roos
    Torrey Pines Therapeutics, Inc, La Jolla, CA 92037, USA
    J Cell Biol 169:435-45. 2005
    ..Similarly, knockdown of the human homologue STIM1 significantly reduced CRAC channel activity in Jurkat T cells...
  17. ncbi Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores
    Jose J Lopez
    Department of Physiology, Cellular Physiology Research Group, University of Extremadura, 10071 Caceres, Spain
    J Biol Chem 281:28254-64. 2006
    STIM1 (stromal interaction molecule 1) has recently been proposed to communicate the intracellular Ca(2+) stores with the plasma membrane to mediate store-operated Ca(2+) entry...
  18. pmc STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane
    Olivier Mignen
    Department of Pharmacology and Physiology, Box 711, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Physiol 579:703-15. 2007
    ..Here we show that STIM1 also regulates the arachidonic-acid-regulated Ca2+-selective (ARC) channels - receptor-activated Ca2+ entry ..
  19. doi Visualizing the store-operated channel complex assembly in real time: identification of SERCA2 as a new member
    Alicia Sampieri
    Instituto de Fisiologia Celular, Departamento de Biologia Celular, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, DF 04510, Mexico
    Cell Calcium 45:439-46. 2009
    ..The stromal interacting molecule (STIM1) has been recently identified as the calcium sensor located at the endoplasmic reticulum (ER), and responsible for ..
  20. pmc Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel
    Takumi Kawasaki
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    J Biol Chem 285:25720-30. 2010
    ..Orai1 and STIM1 are crucial for SOC channel activation, but the molecular mechanisms regulating Orai1 function are not fully ..
  21. pmc Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation
    Bo Liu
    Division of Therapeutics and Molecular Medicine, Respiratory Biomedical Research Unit, Queens Medical Centre, Nottingham, UK
    Respir Res 11:168. 2010
    ..The aim of this study was to characterise the expression and physiological function of the Na+/Ca2+ exchanger in cultured human bronchial smooth muscle cells and determine its contribution to agonist induced Ca2+ influx into these cells...
  22. pmc Genetic polymorphisms of stromal interaction molecule 1 associated with the erythrocyte sedimentation rate and C-reactive protein in HLA-B27 positive ankylosing spondylitis patients
    James Cheng Chung Wei
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    PLoS ONE 7:e49698. 2012
    ..In this study, we enrolled 361 AS patients and selected four tagging single nucleotides polymorphisms (tSNPs) at STIM1 gene...
  23. pmc The Orai-1 and STIM-1 complex controls human dendritic cell maturation
    Romain Felix
    EA 4245 Cellules Dendritiques, Immunomodulation et Greffes, Universite Francois Rabelais, IFR 136 Agents Transmissibles et Infectiologie, UFR de Medecine, Tours, France
    PLoS ONE 8:e61595. 2013
    ..Recent works identified STIM1 and Orai1 in human T lymphocytes as essential for CRAC channel activation...
  24. pmc Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1)
    Kyu Pil Lee
    From the Department of Physiology, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Biol Chem 289:6372-82. 2014
    ..TRPCs are gated open by the endoplasmic reticulum Ca(2+) sensor STIM1. Here we asked which stromal interaction molecule 1 (STIM1) and TRPC domains mediate the interaction between them and how this interaction is used to open ..
  25. pmc Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis
    Vasyl Nesin
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104
    Proc Natl Acad Sci U S A 111:4197-202. 2014
    ..mutations in the CRAC channel pore-forming protein ORAI1 or the Ca(2+) sensing protein stromal interaction molecule 1 (STIM1) result in severe immune dysfunction and nonprogressive myopathy...
  26. doi Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2
    Le Zheng
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada M5G 1L7
    Biochem Biophys Res Commun 369:240-6. 2008
    b>Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER)-membrane associated Ca(2+) sensor which activates store-operated Ca(2+) entry (SOCE)...
  27. doi Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells
    Katsuya Hirano
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Cell Biochem 108:499-507. 2009
    ..Recent studies have identified stromal interaction molecule 1 (STIM1) to function as a sensor of the store site Ca(2+) content, thereby regulating the store-..
  28. pmc Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)
    Sonal Srikanth
    Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:8682-7. 2012
    ..Orai1 is a pore subunit of CRAC channels, and STIM1 acts as an endoplasmic reticulum (ER) Ca(2+) sensor that detects store depletion...
  29. pmc Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress
    Nadine Henke
    Department of Neurology, Medical Faculty, Heinrich Heine Universitat Dusseldorf, D 40225 Dusseldorf, Germany
    J Biol Chem 287:42042-52. 2012
    ..over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1...
  30. doi Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation
    Martin Muik
    Institute of Biophysics, University of Linz, A 4040 Linz, Austria
    J Biol Chem 283:8014-22. 2008
    b>STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 ..
  31. pmc STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
    Shenyuan L Zhang
    Department of Physiology and Biophysics and Center for Immunology, University of California, Irvine, California 92697, USA
    Nature 437:902-5. 2005
    ..Previously we identified Stim and the mammalian homologue STIM1 as essential components of CRAC channel activation in Drosophila S2 cells and human T lymphocytes...
  32. pmc From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum
    Lelio Orci
    Department of Cell Physiology and Metabolism, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 106:19358-62. 2009
    ..Precortical subdomains of the ER enriched in STIM1 can form without contacting the plasma membrane...
  33. pmc A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1
    Nathaniel Calloway
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 49:1067-71. 2010
    ..ubiquitous signaling process in eukaryotic cells in which the endoplasmic reticulum (ER)-localized Ca(2+) sensor, STIM1, activates the plasma membrane-localized Ca(2+) release-activated Ca(2+) (CRAC) channel, Orai1, in response to ..
  34. ncbi STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels
    Guo N Huang
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 8:1003-10. 2006
    ..of I(crac) and SOC channels have not been precisely determined, notable recent findings are the identification of STIM1, which has been indicated to regulate SOC and I(crac) channels by functioning as an endoplasmic reticulum Ca2+ ..
  35. pmc A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
    Samantha E Peel
    Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, UK
    Respir Res 7:119. 2006
    ..The mechanism underlying SOC activation following depletion of intracellular Ca2+ stores in smooth muscle has not been identified...
  36. pmc Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components
    Hwei Ling Ong
    Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:9105-16. 2007
    ..Recently, Orai1 and STIM1 have been suggested to be sufficient for generating CRAC channels...
  37. pmc SOAR and the polybasic STIM1 domains gate and regulate Orai channels
    Joseph P Yuan
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Cell Biol 11:337-43. 2009
    ..Orai channels are SOCs that are gated by STIM1, a Ca(2+) sensor located in the ER but how it gates and regulates the Orai channels is unknown...
  38. pmc TRPC channels function independently of STIM1 and Orai1
    Wayne I Dehaven
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences NIH, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Physiol 587:2275-98. 2009
    Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca(2+)-release activated Ca(2+) (CRAC) channels, channels underlying store-operated Ca(2+) entry (SOCE)...
  39. pmc A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels
    Takumi Kawasaki
    Department of Pathology, New York University Langone Medical Center, SRB 316, 550 First Avenue, New York, NY 10016, USA
    Biochem Biophys Res Commun 385:49-54. 2009
    ..We identified a minimal activation domain in the cytoplasmic region of STIM1 (CCb9) which activated Ca(2+) influx and CRAC currents (I(CRAC)) in the absence of store depletion similar to but ..
  40. pmc Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1
    Owen M Woodward
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e12305. 2010
    ..Interestingly, we also found that in PC1 expressing MDCK cells, translocation of the ER Ca(2+) sensor protein STIM1 to the cell periphery was significantly altered...
  41. pmc Regulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS)
    Jeffrey M Keil
    Section of Neurobiology, Department of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e13465. 2010
    ..Using these methods, we have identified Stromal interacting molecule 1 (STIM1)...
  42. pmc Molecular determinants within N terminus of Orai3 protein that control channel activation and gating
    Judith Bergsmann
    Institute of Biophysics, University of Linz, Altenbergerstrasse 69, 4040 Linz, Austria
    J Biol Chem 286:31565-75. 2011
    b>STIM1 and Orai represent the key components of Ca(2+) release-activated Ca(2+) channels. Activation of Orai channels requires coupling of the C terminus of STIM1 to the N and C termini of Orai...
  43. pmc Gated regulation of CRAC channel ion selectivity by STIM1
    Beth A McNally
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8 296, Chicago, Illinois 60611, USA
    Nature 482:241-5. 2012
    ..Ca(2+) (CRAC) channels, the molecular mechanism of channel gating by the CRAC channel activator, stromal interaction molecule 1 (STIM1), remains unknown...
  44. doi Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells
    Junko Yoshida
    Departments of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Biochem Pharmacol 84:1592-603. 2012
    ..b>Stromal interaction molecule 1 (STIM1), a newly identified Ca(2+)-sensing protein, monitors the depletion of endoplasmic reticulum (..
  45. pmc Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
    Ciara M Walsh
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Biochem J 425:159-68. 2009
    ..It has been suggested that an additional interaction of the C-terminal polybasic domain of STIM1 with PM phosphoinositides could contribute to STIM1 puncta formation prior to binding to Orai...
  46. ncbi Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation
    Zhengzheng Li
    National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Chaoyang District, Beijing 100101, China
    J Biol Chem 282:29448-56. 2007
    b>STIM1 and Orai1 are essential components of Ca(2+) release-activated Ca(2+) channels (CRACs)...
  47. ncbi GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development
    S Sabbioni
    Department of Experimental and Diagnostic Medicine and Interdepartment Center for Biotechnology, University of Ferrara, Italy
    Cancer Res 57:4493-7. 1997
    The expression of GOK, a gene recently identified at 11p15.5, was studied in breast cancer, rhabdomyosarcoma, and rhabdoid tumor cell lines...
  48. ncbi Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
    Christine Peinelt
    Center for Biomedical Research at The Queen s Medical Center and John A Burns School of Medicine at the University of Hawaii, Honolulu, HI 96813, USA
    Nat Cell Biol 8:771-3. 2006
    ..b>STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) ..
  49. ncbi Orai1 and STIM reconstitute store-operated calcium channel function
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, 21201, USA
    J Biol Chem 281:20661-5. 2006
    The two membrane proteins, STIM1 and Orai1, have each been shown to be essential for the activation of store-operated channels (SOC). Yet, how these proteins functionally interact is not known...
  50. pmc Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE)
    Biswaranjan Pani
    Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58201, USA
    J Biol Chem 283:17333-40. 2008
    Store depletion induces STIM1 to aggregate and relocate into clusters at ER-plasma membrane junctions where it functionally interacts with and activates plasma membrane channels that mediate store-operated Ca(2+) entry (SOCE)...
  51. pmc Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps
    Valarie A Barr
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892 4256, USA
    Mol Biol Cell 19:2802-17. 2008
    The proteins STIM1 and Orai1 are the long sought components of the store-operated channels required in T-cell activation. However, little is known about the interaction of these proteins in T-cells after engagement of the T-cell receptor...
  52. pmc ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
    Michael Chvanov
    Department of Physiology, The University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    Pflugers Arch 457:505-17. 2008
    ..of the endoplasmic reticulum (ER) calcium store triggers translocation of stromal interacting molecule one (STIM1) to the sub-plasmalemmal region and formation of puncta-structures in which STIM1 interacts and activates calcium ..
  53. pmc Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis
    Jeremy T Smyth
    Laboratory of Signal Transduction and National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Nat Cell Biol 11:1465-72. 2009
    ..We found that the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 failed to rearrange into near-plasma membrane puncta in mitotic cells, a critical step in the SOCE-activation ..
  54. pmc Identification of stromal cell products that interact with pre-B cells
    K Oritani
    Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    J Cell Biol 134:771-82. 1996
    ..Three of them promoted the survival and/or proliferation of pre-B cells in culture, and all merit further study in relation to lympho-hematopoiesis...
  55. ncbi Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5
    N J Parker
    Department of Haematology and Oncology, Royal Children s Hospital, Parkville, Victoria, Australia
    Genomics 37:253-6. 1996
    A novel gene (GOK) has been cloned from human chromosome region 11p15.5 that is believed to contain a gene or genes associated with a number of pediatric malignancies, including Wilms tumor...
  56. ncbi Exon structure and promoter identification of STIM1 (alias GOK), a human gene causing growth arrest of the human tumor cell lines G401 and RD
    S Sabbioni
    Department of Experimental Medicine, Section of Microbiology, and Interdepartmental Center for Biotechnology, University of Ferrara, Ferrara, Italy
    Cytogenet Cell Genet 86:214-8. 1999
    The stromal interaction molecular 1 gene (STIM1) encodes a type I trans-membrane protein of unknown function, which induces growth arrest and degeneration of the human tumor cell lines G401 and RD but not HBL100 and CaLu-6, suggesting a ..
  57. pmc Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
    R T Williams
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia
    Biochem J 357:673-85. 2001
    b>STIM1 (where STIM is stromal interaction molecule) is a candidate tumour suppressor gene that maps to human chromosome 11p15.5, a region implicated in a variety of cancers, particularly embryonal rhabdomyosarcoma...
  58. ncbi Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation
    Richard T Williams
    Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Biochim Biophys Acta 1596:131-7. 2002
    b>Stromal interaction molecule 1 (STIM1) is a cell surface transmembrane glycoprotein implicated in tumour growth control and stromal-haematopoietic cell interactions...
  59. pmc STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Jen Liou
    Department of Molecular Pharmacology, Stanford University Medical School, California 94305, USA
    Curr Biol 15:1235-41. 2005
    ..signaling proteins, and we identified two proteins required for Ca(2+)-store-depletion-mediated Ca(2+) influx, STIM1 and STIM2...
  60. pmc STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels
    Maria A Spassova
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:4040-5. 2006
    ..The single transmembrane-spanning Ca(2+)-binding protein, STIM1, is necessary in this coupling process and is proposed to function as an ER Ca(2+) sensor to provide the trigger ..
  61. ncbi STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
    Jonathan Soboloff
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, 21201, USA
    Curr Biol 16:1465-70. 2006
    ..b>STIM1 was shown to play a crucial role in this coupling process [4-7]; however, the role of the closely related STIM2 ..
  62. pmc Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
    Minnie M Wu
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Biol 174:803-13. 2006
    Stromal interacting molecule 1 (STIM1), reported to be an endoplasmic reticulum (ER) Ca(2+) sensor controlling store-operated Ca(2+) entry, redistributes from a diffuse ER localization into puncta at the cell periphery after store ..
  63. ncbi Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry
    Peter B Stathopulos
    Division of Signaling Biology and Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto M5G 1L7, Ontario, Canada
    J Biol Chem 281:35855-62. 2006
    b>Stromal interaction molecule 1 (STIM1) has recently been identified as a key player in store-operated Ca2+ entry...
  64. ncbi Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
    Pingyong Xu
    National Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, PR China
    Biochem Biophys Res Commun 350:969-76. 2006
    b>STIM1 and Orai1 have recently been identified to be crucial in the regulation of store-operated Ca(2+) entry. However, it remains to be established how STIM1 couples store depletion to the functioning of Orai1 in the plasma membrane...
  65. ncbi STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulum
    Hélène Jousset
    Department of Cell Physiology and Metabolism, University of Geneva Medical School, 1 Michel Servet, CH 1211 Geneva 4, Switzerland
    J Biol Chem 282:11456-64. 2007
    ..To test whether STIM1 is required for ER refilling, we used RNA interference and measured Ca2+ signals in the cytosol, the ER, and the ..
  66. pmc A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure
    Christina T Hauser
    Department of Pharmacology, Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093 0647, USA
    Proc Natl Acad Sci U S A 104:3693-7. 2007
    ..label helps to resolve a current controversy concerning externalization of the stromal interaction molecule STIM1 upon depletion of Ca(2+) from the endoplasmic reticulum...
  67. pmc STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
    Joseph P Yuan
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Nat Cell Biol 9:636-45. 2007
    Stromal interacting molecule 1 (STIM1) is a Ca(2+) sensor that conveys the Ca(2+) load of the endoplasmic reticulum to store-operated channels (SOCs) at the plasma membrane...
  68. pmc Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
    Jen Liou
    Department of Chemical and Systems Biology, Stanford University Medical School, 318 Campus Drive, Clark Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:9301-6. 2007
    b>Stromal interaction molecule 1 (STIM1) has recently been identified by our group and others as an endoplasmic reticulum (ER) Ca(2+) sensor that responds to ER Ca(2+) store depletion and activates Ca(2+) channels in the plasma membrane (PM)..
  69. ncbi Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 Complex
    Peter Varnai
    Section on Molecular Signal Transduction, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 282:29678-90. 2007
    b>STIM1, a recently identified endoplasmic reticulum (ER) protein, rapidly translocates to a plasma membrane-adjacent ER compartment upon depletion of the ER Ca(2+) stores...
  70. pmc STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation
    Suhel Parvez
    Center for Biomedical Research and John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    FASEB J 22:752-61. 2008
    b>STIM1 and CRACM1 (or Orai1) are essential molecular components mediating store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) currents...
  71. pmc Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1
    Jeremy T Smyth
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Cell Sci 120:3762-71. 2007
    ..and store-operated Ca(2+) entry (SOCE) function of the endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) in HEK 293 cells...
  72. pmc STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER
    Ilya Grigoriev
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:177-82. 2008
    b>Stromal interaction molecule 1 (STIM1) is a transmembrane protein that is essential for store-operated Ca(2+) entry, a process of extracellular Ca(2+) influx in response to the depletion of Ca(2+) stores in the endoplasmic reticulum (ER) (..
  73. pmc Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation
    Maria I Lioudyno
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 105:2011-6. 2008
    ..Recent RNAi screens have identified Stim and Orai in Drosophila cells, and their corresponding mammalian homologs STIM1 and Orai1 in T cells, as essential for CRAC channel activation...
  74. pmc Soft substrate up-regulates the interaction of STIM1 with store-operated Ca2+ channels that lead to normal epithelial cell apoptosis
    Wen Tai Chiu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:2220-30. 2008
    ..Concomitantly, soft substrate induced the aggregation and translocation of stromal interacting molecule 1 (STIM1) toward the cell periphery to colocalize with Orai1, an essential pore subunit of SOC channel, detected by ..
  75. pmc 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
    Christine Peinelt
    Queen s Medical Center and John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    J Physiol 586:3061-73. 2008
    ..of 2-APB and report that it can activate CRACM3 channels in a store-independent manner without the requirement of STIM1, whereas CRACM2 by itself is completely unresponsive to 2-APB and CRACM1 is only very weakly activated...
  76. doi Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry
    Mikael C Bauer
    Lund University, Biophysical Chemistry, Chemical Centre, P O Box 124, SE221 00 Lund, Sweden
    Biochemistry 47:6089-91. 2008
    Translocation of STIM1 and STIM2 from the endoplasmic reticulum to the plasma membrane is a key step in store-operated calcium entry in the cell...
  77. pmc STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy
    Laura Navarro-Borelly
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, 303 E Chicago Avenue, Ward 8 296, Chicago, IL 60611, USA
    J Physiol 586:5383-401. 2008
    ..Activation of CRAC channels by store depletion involves the redistribution of the ER Ca(2+) sensor, stromal interaction molecule 1 (STIM1), to peripheral sites where it co-clusters with the CRAC channel subunit, Orai1...
  78. pmc Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation
    Iskandar F Abdullaev
    Cardiovascular Sciences, MC8, Albany Medical College, 47 New Scotland Avenue, MC 8, Albany, NY 12208, USA
    Circ Res 103:1289-99. 2008
    Recent breakthroughs in the store-operated calcium (Ca(2+)) entry (SOCE) pathway have identified Stim1 as the endoplasmic reticulum Ca(2+) sensor and Orai1 as the pore forming subunit of the highly Ca(2+)-selective CRAC channel expressed ..
  79. doi Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
    Peter B Stathopulos
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Cell 135:110-22. 2008
    Stromal interaction molecule-1 (STIM1) activates store-operated Ca2+ entry (SOCE) in response to diminished luminal Ca2+ levels...
  80. doi An essential role for stromal interaction molecule 1 in neointima formation following arterial injury
    Rui wei Guo
    Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Cardiovasc Res 81:660-8. 2009
    There is evidence to suggest that stromal interaction molecule 1 (STIM1) functions as a Ca2+ sensor on the endoplasmic reticulum, leading to transduction of signals to the plasma membrane and opening of store-operated Ca2+ channels (SOC)...
  81. doi STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation
    Basile Darbellay
    Department of Clinical Neurosciences, Faculty of Medicine, University of Geneva, Switzerland
    J Biol Chem 284:5370-80. 2009
    ..We found that SOCE orchestrated by STIM1, the endoplasmic reticulum Ca(2+) sensor activating Orai Ca(2+) channels, is crucial...
  82. pmc RNA interference targeting STIM1 suppresses vascular smooth muscle cell proliferation and neointima formation in the rat
    Fleur C Aubart
    INSERM UMR S 956, Paris, France
    Mol Ther 17:455-62. 2009
    Our objective was to study the expression and function of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum protein recently identified as the calcium sensor that regulated Ca(2+)-released activated channels in T cells...
  83. doi Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
    Shengyu Yang
    Department of Physiology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cancer Cell 15:124-34. 2009
    ..We report here that Orai1 and STIM1, both of which are involved in store-operated calcium entry, are essential for breast tumor cell migration in ..
  84. pmc A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels
    Martin Muik
    Institute of Biophysics, University of Linz, A 4040 Linz
    J Biol Chem 284:8421-6. 2009
    ..Molecular key players in this process comprise the stromal interaction molecule 1 (STIM1) that functions as a Ca(2+) sensor in the endoplasmic reticulum and ORAI1 located in the plasma ..
  85. pmc STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA
    Cell 136:876-90. 2009
    ..After store depletion, the ER Ca(2+) sensor STIM1 and the CRAC channel protein Orai1 redistribute to ER-plasma membrane (PM) junctions, but the fundamental issue of ..
  86. doi Store-operated cyclic AMP signalling mediated by STIM1
    Konstantinos Lefkimmiatis
    VA Boston Healthcare System and the Department of Surgery, Brigham and Women s Hospital and Harvard Medical School, West Roxbury, Massachusetts 02132, USA
    Nat Cell Biol 11:433-42. 2009
    ..This 'store-operated' process requires translocation of a transmembrane ER Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to sites closely apposed to Ca(2+) channels at the cell surface...
  87. pmc The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels
    Yandong Zhou
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:19164-8. 2009
    b>STIM1 and STIM2 are dynamic transmembrane endoplasmic reticulum Ca(2+) sensors, coupling directly to activate plasma membrane Orai Ca(2+) entry channels. Despite extensive sequence homology, the STIM proteins are functionally distinct...
  88. pmc Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    Irene Frischauf
    Institute of Biophysics, University of Linz, A 4040 Linz, Austria
    J Biol Chem 284:21696-706. 2009
    b>STIM1 and Orai1 have been reported to interact upon store depletion culminating in Ca(2+) release-activated Ca(2+) current activation...
  89. pmc A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels
    Isabella Derler
    Institute of Biophysics, University of Linz, A 4040 Linz, Austria
    J Biol Chem 284:24933-8. 2009
    b>STIM1 and ORAI1, the two limiting components in the Ca(2+) release-activated Ca(2+) (CRAC) signaling cascade, have been reported to interact upon store depletion, culminating in CRAC current activation...
  90. doi Store-operated Ca2+ entry is sensitive to the extracellular Ca2+ concentration through plasma membrane STIM1
    Isaac Jardin
    Department of Physiology Cellular Physiology Research Group, University of Extremadura, 10071 Caceres, Spain
    Biochim Biophys Acta 1793:1614-22. 2009
    ..Here we have examined the involvement of plasma membrane-located STIM1 (PM-STIM1) in the regulation of SOCE by extracellular Ca(2+)...
  91. doi An EB1-binding motif acts as a microtubule tip localization signal
    Srinivas Honnappa
    Biomolecular Research, Structural Biology, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
    Cell 138:366-76. 2009
    ..Ser-x-Ile-Pro (SxIP), is used by numerous +TIPs, including the tumor suppressor APC, the transmembrane protein STIM1, and the kinesin MCAK, for localization to microtubule tips in an EB1-dependent manner...
  92. pmc Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels
    Kyu Pil Lee
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:14687-92. 2009
    ..One form of SOC is the CRAC current that is mediated by Orai channels activated by STIM1. A fundamental property of the native CRAC and of the Orais is fast Ca(2+)-dependent inactivation, which limits Ca(..
  93. doi ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond
    Stefan Feske
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Immunol Rev 231:189-209. 2009
    ..ORAI1 as the pore-forming subunit of the CRAC channel in the plasma membrane and stromal interaction molecule-1 (STIM1) sensing the ER Ca2+ concentration and activating ORAI1-CRAC channels...
  94. pmc Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1
    Elizabeth D Covington
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 21:1897-907. 2010
    Oligomerization of the ER Ca(2+) sensor STIM1 is an essential step in store-operated Ca(2+) entry...
  95. pmc Human muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2
    Basile Darbellay
    Department of Clinical Neurosciences, University Hospital of Geneva, CH 1211 Geneve 4, Switzerland
    J Biol Chem 285:22437-47. 2010
    ..2009) J. Biol. Chem. 284, 5370-5380). The present work indicates that STIM2 silencing, similar to STIM1 silencing, reduces myoblast SOCE amplitude and differentiation...
  96. pmc S-glutathionylation activates STIM1 and alters mitochondrial homeostasis
    Brian J Hawkins
    Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA
    J Cell Biol 190:391-405. 2010
    ..elevated pattern via calcium release-activated calcium (CRAC)-mediated capacitive Ca(2+) entry, and stromal interaction molecule 1 (STIM1)- and Orai1-deficient cells are resistant to oxidant stress...
  97. doi Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry
    Eulalia Pozo-Guisado
    Department of Biochemistry and Molecular Biology, College of Life Sciences, University of Extremadura, Badajoz 06071, Spain
    J Cell Sci 123:3084-93. 2010
    ..Upon store depletion, STIM1, a transmembrane protein located in the endoplasmic reticulum (ER), aggregates and relocates close to the plasma ..
  98. doi The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels
    Chan Young Park
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 330:101-5. 2010
    ..We found that STIM1 (stromal interaction molecule 1), the main activator of store-operated Ca(2+) channels, directly suppresses depolarization-induced ..
  99. pmc Activation of STIM1-Orai1 involves an intramolecular switching mechanism
    Marek K Korzeniowski
    Section on Molecular Signal Transduction, Program for Developmental Neuroscience, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Sci Signal 3:ra82. 2010
    b>Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca(2+)) entry through plasma membrane Orai1 channels in response to decreased Ca(2+) concentrations in the endoplasmic reticulum lumen...
  100. pmc Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry
    Le Zheng
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 1L7
    Proc Natl Acad Sci U S A 108:1337-42. 2011
    ..To probe the structural basis for the functional differences between STIM1 and STIM2 we engineered a series of EF-hand and sterile α motif (SAM) domain (EF-SAM) chimeras, demonstrating ..
  101. pmc STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
    Martin Muik
    Institute of Biophysics, University of Linz, Linz, Austria
    EMBO J 30:1678-89. 2011
    Stromal interaction molecule (STIM1) and ORAI1 are key components of the Ca(2+) release-activated Ca(2+) (CRAC) current having an important role in T-cell activation and mast cell degranulation...

Research Grants65

  1. Clifford A Lowell; Fiscal Year: 2016
    ..of SOCE has recently been defined through the identification of the intracellular calcium sensor proteins, STIM1 and STIM2, and the plasma membrane calcium channel proteins ORAI1, 2 and 3...
  2. The Role of Stanniocalcin 2 in Calcium Homeostasis and Neuronal Pathology
    WILLIAM ABEL ZEIGER; Fiscal Year: 2012
    ..Aim 1: Investigate the effect of STC2 expression on STIM1 function My preliminary data demonstrates that loss of STC2 expression leads to an increase in calcium entry ..
  3. David A Holowka; Fiscal Year: 2014
    ..energy transfer imaging for measurements of molecular proximity between this channel and the calcium sensor, STIM1. We will utilize this method to characterize the mechanism for regulation of Ca2+ influx by phosphatidylinositol 4,..
  4. Suzette Farber-Katz; Fiscal Year: 2014
    ..Store depletion results in the activation of the ORAI plasma membrane Ca2+ channels by STIM1, a Ca2+ sensor in the endoplasmic reticulum...
  5. Iain A Drummond; Fiscal Year: 2014
    ..calcium in polycystin deficient embryos and assaying for genetic interactions of polycystin1 and polycystin2 with stim1 and orai1, the recently discovered store operated calcium channels...
  6. Mohamed Trebak; Fiscal Year: 2014
    ..Our preliminary studies have demonstrated an increase in TRPC6 and the newly discovered calcium sensor STIM1, and calcium channels Orai1 and Orai3 expression in synthetic cultured rat aortic VSMC, as compared to quiescent ..
  7. Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum
    MICHAEL WILLIAM ROE; Fiscal Year: 2010
    ..Ca2+ signaling;[2] glucose-induced [Ca2+]c and [Ca2+]ER oscillations are temporally and causally interrelated;[3] STIM1 is expressed in B-cells and essential for SOCE;[4] mitochondria and plasma membrane-related Ca2+-ATPase-1 (Pmr-1) ..
  8. Brij B Singh; Fiscal Year: 2016
    ..the regulation of TRPC1 channel we have shown that in human submandibular gland cells, TRPC1 interaction with STIM1, Cav1, and Orai1 dictates TRPC1 mediated calcium entry...
  9. Tobias Meyer; Fiscal Year: 2016
    ..of our grant is to understand the signaling steps linking the endoplasmic reticulum (ER) localized ER Ca2+ sensors STIM1 and STIM2 to the activation of Ca2+ influx across the plasma membrane (PM): store- operated Ca2+-influx (SOC)...
  10. Store Operated Calcium Channels Function in Vascular Smooth Muscle
    Salvatore Mancarella; Fiscal Year: 2012
    ..The work examines the function of two crucial proteins, STIM1 and STIM2, that sense changes in the Ca[2+] within the SR lumen of VSMCS, and through a highly coordinated ..
  11. Store operated calcium influx in cells of the immune system
    JEAN PIERRE M KINET; Fiscal Year: 2012
    ..3 is localized to the ER and forms a stable protein complex with STIM1. This novel observation suggests another fundamental intersection between VOCC channels and CRAC...
  12. Bruce D Freedman; Fiscal Year: 2014
    ..Depletion of IP3-sensitive ER Ca2+ stores triggers relocalization of STIM1, the ER Ca2+ sensor, into punctate structures in junctional ER adjacent to the plasma membrane...
  13. Yousang Gwack; Fiscal Year: 2016
    ..Recently, Orai1 (CRACM1) and STIM1 were identified as a pore component of the CRAC channel and a mediator between Ca2+ store depletion and CRAC ..
  14. JONATHAN A SOBOLOFF; Fiscal Year: 2015
    ..from our lab have led to the identification of Early Growth Response 1 (EGR1) as a regulator of the expression of STIM1, a required component of store-operated Ca2+ entry, the primary means of Ca2+ entry in non-excitable cells...
  15. Guo li Ming; Fiscal Year: 2014
    ..neuronal navigation during early neural development and in the adult brain with the central hypothesis that TRPC, STIM1 and Orai proteins co-operate to set the basal and induced Ca2+ levels for directed motility of growth cones and ..
  16. Peter R Hoffmann; Fiscal Year: 2016
    ..We have identified a novel interaction between Sel K and STIM1, which is a key signaling molecule required for store-operated for calcium (Ca2+) entry during activation of ..
  17. Richard L Huganir; Fiscal Year: 2016
    ..Paul Worley will be analyzing how the Oral and STIM1 proteins control intracellular calcium stores and regulate synaptic plasticity in neurons and astrocytes...
  18. The role of STIM1 in cardiac and skeletal muscle function
    Paul B Rosenberg; Fiscal Year: 2013
    ..Our preliminary data demonstrate that the recently identified calcium sensor stromal interaction molecule 1 (STIM1) is expressed and functional in striated muscle...
  19. FRANKLIN MULLINS; Fiscal Year: 2014
    ..Two essential components of the CRAC channel, the ER Ca2+ sensor STIM1 and the pore-forming subunit Orai1, were identified in 2005 and 2006...
  20. Aldebaran M Hofer; Fiscal Year: 2014
    ..of a previously unknown signaling pathway that connects the endoplasmic reticulum (ER) calcium sensor STIM1 to the production of cAMP in colon crypt- derived cells...
  21. Donald L Gill; Fiscal Year: 2014
    ..crosslinking activates a recently discovered and powerful signaling system mediated by the ER membrane proteins, STIM1 and STIM2...
  22. Trevor J Shuttleworth; Fiscal Year: 2016
    ..Thus, it has been shown that STIM1 located in the membrane of the endoplasmic reticulum, senses the depletion of intracellular Ca2+ stores, and ..
  23. Jean Sebastien Hulot; Fiscal Year: 2016
    ..b>Stromal interaction molecule 1 (STIM1) is a dynamic transmembrane endoplasmic reticulum calcium sensor that activates plasma membrane ..
  24. Calcium Influx Factor
    Victoria M Bolotina; Fiscal Year: 2010
    ..Most recently, we identified STIM1 as a trigger for CIF production in the endoplasmic reticulum...
  25. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..Our Specific Aims are: decrease [Ca2+]i Aim 1: To determine the influence of inflammatory cytokines on STIM1, STIM2 and Orai1 interactions in human ASM regulation;Aim 2: To determine the influence of inflammatory cytokines ..
  26. STIM1 mediated calcium entry: A new paradigm of metabolic regulation of cardiomyo
    John C Chatham; Fiscal Year: 2013
    ..mediating voltage- independent Ca2+ entry, combined with our knowledge of protein O-GlcNAcylation, we propose that STIM1-Orai1 facilitated non-voltage gated Ca2+ entry is a key mediator of Ca2+ signaling in adult cardiomyocytes and ..
  27. Stefan Feske; Fiscal Year: 2016
    ..are encoded by ORAI and STIM family genes and we identified the first patients with mutations in ORAI1 and STIM1 genes...
  28. Robert T Dirksen; Fiscal Year: 2016
    ..We provide strong preliminary data to demonstrate that STIM1 proteins function as the calcium sensor of the sarcoplasmic reticulum (SR) and Orai1 proteins as the calcium ..
  29. Salvatore Mancarella; Fiscal Year: 2014
    ..During his postdoctoral training the candidate has investigated the biophysical properties of the Ca2+ sensors STIM1. These results suggest that STIM forms specialized proteins network able to capture Ca2+ signals from the near-..
  30. Joseph A Hill; Fiscal Year: 2016
    ..STIM1 (stromal interaction molecule 1), a Ca2+ sensor protein, functions to gauge intracellular Ca2+ stores...
  31. Characterization of Genes Responsible for Store-operated Ca2+ Entry in T cells
    Stefan Feske; Fiscal Year: 2010
    ..respect to its ability to promote SOCE and CRAC currents, evaluate its interaction with other proteins, especially STIM1 and STIM2, and establish an in vivo model of the role of this protein in T cell development and T cell-mediated ..
  32. CALCIUM REGULATION IN ORAL HEALTH
    Rodrigo S Lacruz; Fiscal Year: 2013
    ..Patients with mutations to CRAC channels (STIM1, ORAI1) present, in addition to immune system deficiencies, with hypocalcified amelogenesis imperfecta...
  33. JASON EDWARD LEE; Fiscal Year: 2015
    ..ER dynamics along microtubules will be modulated by altering TAC dynamics via STIM1 expression, or ER sliding via HDAC6 expression in breast cancer cells, then testing the sensitivity of these cells ..
  34. Patrick Hogan; Fiscal Year: 2016
    ..of the Ca2+ release-activated Ca2+ (CRAC) channel;(ii) confirmed previous reports that Drosophila Stim and human STIM1 are key regulators of store-operated Ca2+ entry;and (iii) showed that a missense mutation in ORAI1 was responsible ..
  35. Janelle Rowell; Fiscal Year: 2014
    ..in HEK293 cells indicate TRPC channel activity may also be modulated by gating of stromal interacting protein-1 (Stim1) which was recently reported to contribute to the hypertrophic response in vivo...
  36. Richard S Lewis; Fiscal Year: 2016
    ..Depletion of Ca2+ from the endoplasmic reticulum (ER) causes STIM1, an ER Ca2+ sensor, to oligomerize, leading to its accumulation at ER-plasma membrane (PM) junctions...
  37. A new class of immunomodulator, CRAC channel blockers
    Yousang Gwack; Fiscal Year: 2013
    ..Recently, Orai1 and STIM1 were identified as a long-sought pore component of CRAC channels and as an endoplasmic reticulum (ER) Ca2+ sensor, ..
  38. JAMES ROTHMAN; Fiscal Year: 2015
    ..of ER membrane proteins bearing the C-terminal peptide from a cER protein, such as yeast Ist2p and mammalian STIM1, which triggers proliferation of cER containing this protein in various mammailian cells that normally have little ..
  39. Michael D Cahalan; Fiscal Year: 2016
    ..In the immune system, STIM1 and Orai1 mediate antigen-induced Ca2+ signaling, motility inhibition at the site of antigen presentation, ..
  40. Store-Operated Ca entry and iPLA2 in vascular SMC
    Victoria M Bolotina; Fiscal Year: 2012
    ..of iPLA2[unreadable] was fully confirmed in a recent screen of Drosophila genes, in which iPLA2[unreadable], STIM1 and Orai1 (but not TRP) were found to play equally important roles in SOCE, but the mechanisms of their molecular ..
  41. Ayako Makino; Fiscal Year: 2015
    ..In Aim 2, we will investigate the potential role of STIM1 in decreased [Ca2+]ER in diabetic coronary ECs...
  42. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..on agonist receptors, second messengers (PLC/IP3, cADPR), regulation of store-operated Ca2+ entry (SOCE) by (STIM1/Orai1), and RhoA (Ca2+ sensitization)...
  43. ROS-dependent STIM1 activation and Ca2+ entry in lung inflammation
    Jonathan Soboloff; Fiscal Year: 2012
    ..Further, we have recently demonstrated that the ER resident Ca2+ sensor STIM1 is also a ROS target...
  44. Control of Vascular Cell Motility by CaMKII
    Harold A Singer; Fiscal Year: 2013
    ..Based on this, in Aim 3 we molecular and fluorescence imaging approaches to test the hypothesis that STIM1/Orai1 mediated Ca2+ entry is functionally linked to leading edge CaMKII activation...
  45. Dissection of the Modular Structure of Cancer Signaling Systems
    Tobias Meyer; Fiscal Year: 2010
    ..Using these siRNAs, we have already discovered the function of STIM1, a Ca2+ sensor in the ER lumen that controls Ca2+ influx into cells, and which also acts as a tumor suppressor...
  46. Jian Ying Wang; Fiscal Year: 2016
    ..Recently, stromal interaction molecule 1 (STIM1) was identified in screens for molecules that are essential for the activation of store-..
  47. Carlos Fernando Valenzuela; Fiscal Year: 2016
    ..EtOH causes persistent L-VGCC inhibition by inducing channel degradation via depletion of internal Ca2+ stores and STIM1 binding to 11 subunits...
  48. Gating mechanism of TRPCs and Orai1 by STIM1 & their role in cardiac hypertrophy
    Joseph P Yuan; Fiscal Year: 2010
    ..In Aim 1, we will determine the gating mechanism of TRPCs by STIM1 and Homer and how STIM1 and Homer work in tandem to regulate the TRPCs...
  49. Ardem Patapoutian; Fiscal Year: 2014
    ..We have recently shown that STIM1/Orai1 ion channel complex is acutely thermosensitive...
  50. Murali Prakriya; Fiscal Year: 2016
    ..Emerging evidence in our laboratory indicates that CRAC channels arising from the canonical Orai1-STIM1 proteins comprise a major route of Ca2+ entry in NSCs...
  51. Hormone Regulation of [Ca2+] in Pancreatic Acinar Cells
    JAMES TRAVIS STULL; Fiscal Year: 2010
    ..several Ca2+ influx channels, TRPC1, TRPC3, TRPC4, TRPC6 and Orai1, all of which are gated by the ER Ca2+ sensor STIM1. TRPCs are also gated by the scaffold Homer1 that inhibits their activity...
  52. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2012
    ..We recently discovered Stim and STIM1 as essential and conserved components of CRAG channel function in Drosophila and human cells...
  53. Gating mechanism of TRPCs and Orai1 by STIM1 &their role in cardiac hypertrophy
    Joseph P Yuan; Fiscal Year: 2013
    ..In Aim 1, we will determine the gating mechanism of TRPCs by STIM1 and Homer and how STIM1 and Homer work in tandem to regulate the TRPCs...
  54. Store-operated channels in the nervous system
    Murali Prakriya; Fiscal Year: 2012
    ..Emerging evidence in our laboratory indicates that CRAC channels encoded by the canonical Orai1-STIM1 pathway are a major route of Ca2+ entry in NSCs...
  55. Dolly Mehta; Fiscal Year: 2016
    ..that FAK induces microRNA-150 (miR-150) expression which targets the Ca2+ sensor, stromal interacting molecule 1 (STIM1)...
  56. Elsie Samakai; Fiscal Year: 2016
    ..Recent investigations in the lab have revealed Early Growth Response 1 (EGR1) as a direct regulator of STIM1 expression (a required component of SOCe)...
  57. Structure and Function of Ocular Lacritin
    GORDON LAURIE; Fiscal Year: 2007
    ..inhibitor techniques, we then determined that lacritin signals from Ga1, or Ga0 to PLC-PKCa/PLD/mTOR and PLCPKCa/ STIM1/calcineurin/Ca2+/NFATC1 to activate secretory and mitogenic responses...
  58. Dissection of the Modular Structure of Cancer Signaling Systems
    Tobias Meyer; Fiscal Year: 2006
    ..Using these siRNAs, we have already discovered the function of STIM1, a Ca2+ sensor in the ER lumen that controls Ca2+ influx into cells, and which also acts as a tumor suppressor...
  59. Signaling Pathways in Salivary Gland Fluid Secretion
    Trevor Shuttleworth; Fiscal Year: 2009
    ..abstract_text> ..
  60. FASEB Conference on Calcium and Cell Function
    Richard Lewis; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  61. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2005
    ..abstract_text> ..
  62. Effector IEG, Homer and Drug Addiction
    Paul F Worley; Fiscal Year: 2010
    ..abstract_text> ..
  63. Mechanisms of Growth Cone Turning in Diffusible Gradient
    James Zheng; Fiscal Year: 2006
    ....
  64. Culture of differentiated C elegans embryonic cells
    Kevin Strange; Fiscal Year: 2002
    ..The speed and economy with which this can be done in C. elegans cannot be duplicated in other metazoan animals. ..

Patents1

  1. T cell activating gene
    Patent Number: WO2004058805-A2; Date:2004-07-15