stearoyl CoA desaturase

Summary

Gene Symbol: stearoyl CoA desaturase
Description: stearoyl-CoA desaturase
Alias: FADS5, MSTP008, SCD1, SCDOS, hSCD1, acyl-CoA desaturase, delta(9)-desaturase, fatty acid desaturase, stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-CoA desaturase opposite strand
Species: human

Top Publications

  1. ncbi Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
  2. ncbi Stearoyl-CoA desaturase-1 and the metabolic syndrome
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:271-80. 2003
  3. pmc Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    Mélaine Minville-Walz
    Universite de Bourgogne, Centre de Recherche INSERM Lipides, Nutrition, Cancer UMR866, Dijon, France
    PLoS ONE 5:e14363. 2010
  4. pmc Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression
    Yoshimi Ide
    Department of Surgery I, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 8:e61204. 2013
  5. pmc Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
    Harini Sampath
    From the Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon 97239 and
    J Biol Chem 289:2482-8. 2014
  6. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
  7. pmc Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects
    Sara García-Serrano
    CIBER Diabetes and Associated Metabolic Disorders, ISCIII, Spain
    Mol Med 17:273-80. 2011
  8. pmc Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness
    Aiwei Yao-Borengasser
    Research, 598 151, Central Arkansas Veterans Healthcare System, Department of Medicine, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4431-9. 2008
  9. ncbi Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues
    J Li
    Department of Molecular and Cellular Physiology, Institute of Animal Physiology, Babraham, Cambridge, UK
    Int J Cancer 57:348-52. 1994
  10. ncbi Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma
    Stacy Moore
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 114:563-71. 2005

Research Grants

  1. Primary Prevention of Strokes in Nigerian Children with Sickle Cell Disease
    LORI CHAFFIN JORDAN; Fiscal Year: 2013
  2. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
  3. Thomas W Glover; Fiscal Year: 2016
  4. Peter G Vekilov; Fiscal Year: 2016
  5. JOSHUA JEFFREY FIELD; Fiscal Year: 2016
  6. Educational Attainment in Sickle Cell Disease
    Allison A King; Fiscal Year: 2010
  7. SOPHIE M LANZKRON; Fiscal Year: 2014
  8. Enrico M Novelli; Fiscal Year: 2016
  9. Protein biomarkers of pulmonary hypertension in sickle cell disease
    Mark E McComb; Fiscal Year: 2013
  10. Mitchell S Cairo; Fiscal Year: 2015

Detail Information

Publications341 found, 100 shown here

  1. ncbi Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  2. ncbi Stearoyl-CoA desaturase-1 and the metabolic syndrome
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:271-80. 2003
    ..These findings indicate that pharmacologic manipulation of SCD-1 may be of benefit in the treatment of obesity, diabetes, hepatic steatosis, and other components of the Metabolic Syndrome...
  3. pmc Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    Mélaine Minville-Walz
    Universite de Bourgogne, Centre de Recherche INSERM Lipides, Nutrition, Cancer UMR866, Dijon, France
    PLoS ONE 5:e14363. 2010
    ..This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid)...
  4. pmc Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression
    Yoshimi Ide
    Department of Surgery I, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 8:e61204. 2013
    ..The protein expression of stearoyl-CoA desaturase-1 (SCD1), which is a synthetic enzyme of MUFA, showed accumulation in the cancerous areas as observed by the results of ..
  5. pmc Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
    Harini Sampath
    From the Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon 97239 and
    J Biol Chem 289:2482-8. 2014
    ..Mice with a deletion of the Δ(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-)) or specifically in the skin (skin-specific Scd1-knockout; SKO) present with marked ..
  6. pmc Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
    Andreas Peter
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 58:1757-65. 2009
    ..Stearoyl-CoA desaturase 1 (SCD1) plays a key role in preventing lipotoxic effects, as it converts SFAs to less harmful monounsaturated fatty acids...
  7. pmc Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects
    Sara García-Serrano
    CIBER Diabetes and Associated Metabolic Disorders, ISCIII, Spain
    Mol Med 17:273-80. 2011
    Animal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity and insulin resistance. However, only a few studies have been undertaken in humans...
  8. pmc Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness
    Aiwei Yao-Borengasser
    Research, 598 151, Central Arkansas Veterans Healthcare System, Department of Medicine, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 93:4431-9. 2008
    Stearoyl-coenzyme A desaturase (SCD1) is the rate-limiting enzyme that converts palmitoyl- and stearoyl-coenzyme A to palmitoleoyl- and oleoyl-cownzyme A, respectively...
  9. ncbi Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues
    J Li
    Department of Molecular and Cellular Physiology, Institute of Animal Physiology, Babraham, Cambridge, UK
    Int J Cancer 57:348-52. 1994
    ..It is suggested that certain classes of tumour may exhibit increased levels of desaturase mRNA...
  10. ncbi Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma
    Stacy Moore
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Int J Cancer 114:563-71. 2005
    ..These results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis...
  11. ncbi Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
    Natalia Scaglia
    Instituto de Investigaciones Bioquimicas de La Plata, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    J Biol Chem 280:25339-49. 2005
    ....
  12. ncbi Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
    Jian Wang
    Cardiovascular Division, Lilly Research Labs, Eli Lilly and Company, DC 0343, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 332:735-42. 2005
    ..Microsome fractions prepared from hSCD1 and hSCD5 transfected cells displayed similar delta 9 desaturase activity...
  13. ncbi Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity
    Eva Warensjo
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 751 85 Uppsala, Sweden
    Obesity (Silver Spring) 15:1732-40. 2007
    ..The lipogenic enzyme, stearoyl-coenzyme A-desaturase (SCD), is related to obesity. Further, SCD1-deficent mice are protected against obesity and insulin resistance...
  14. doi Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
    N Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Diabetologia 51:648-56. 2008
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme in monounsaturated fatty acid synthesis. It is imperative for the assembly of VLDL particles, which transport triacylglycerol (TG) from liver to adipose tissue and other sites...
  15. pmc Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
    Rebecca Mar-Heyming
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 28:1193-9. 2008
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels...
  16. ncbi Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis
    Natalia Scaglia
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    Int J Oncol 33:839-50. 2008
    ..of tissue MUFA and several types of cancer has been reported, but a causal relationship between the function of SCD1, the main human SCD isoform, and cancer development has not yet been firmly established...
  17. pmc Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    Anna Kotronen
    Department of Medicine, Division of Diabetes, Helsinki, Finland
    Diabetes 58:203-8. 2009
    To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver.
  18. doi The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents
    Yuan E Zhou
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    Metabolism 58:158-66. 2009
    ....
  19. pmc Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
    Natalia Scaglia
    Department of Nutritional Sciences and Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    PLoS ONE 4:e6812. 2009
    ..We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, ..
  20. doi Hormonal and nutritional regulation of SCD1 gene expression
    Daniel Mauvoisin
    Departement des Sciences Biologiques, Centre de recherche BioMed, Universite du Quebec a Montreal, C P 8888, Succursale Centre Ville, Montreal, Quebec, Canada
    Biochimie 93:78-86. 2011
    Stearoyl-CoA Desaturase 1 (SCD1) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids preferentially from palmitoyl-CoA and stearoyl-CoA forming respectively palmitoleyl-CoA and oleyl-CoA...
  21. pmc Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults
    Jian Gong
    Department of Community Health, Brown University, Providence, RI, USA
    J Nutr 141:2211-8. 2011
    Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS)...
  22. pmc SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
    Paul Mason
    Genzyme Corporation, Waltham, Massachusetts, United States of America
    PLoS ONE 7:e33823. 2012
    ..Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous ..
  23. pmc Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
    Christina A von Roemeling
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    Clin Cancer Res 19:2368-80. 2013
    We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability in vitro and in vivo independently as well as in ..
  24. ncbi Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism
    C F Liew
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
    Diabetologia 47:2168-75. 2004
    ..Given this strong positional and biological candidacy, the present study sought to establish whether sequence variation in SCD influences susceptibility to type 2 diabetes and related traits...
  25. doi Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans
    Andreas Peter
    Dept of Internal Medicine, University of Tubingen, German Center for Diabetes Research, Germany
    Am J Physiol Endocrinol Metab 300:E321-6. 2011
    Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme...
  26. doi FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth
    Xiangnan Du
    Molecular Oncology, Cancer Signaling and Translational Oncology, Bioinformatics, and Pathology, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 72:5843-55. 2012
    ..In turn, SREBP1 regulates the expression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD)...
  27. pmc Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
    L Zhang
    Skin Biology T R C, Johnson and Johnson, C P W W, Skillman, NJ 08558, USA
    Biochem J 340:255-64. 1999
    ....
  28. ncbi High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts
    Natalia Scaglia
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, 1900 La Plata, Argentina
    Biochim Biophys Acta 1687:141-51. 2005
    ..The strong correlation of high levels of MUFA and neoplastic phenotype suggest that the regulation of stearoyl CoA desaturase (SCD) must play a significant role in cancer development...
  29. pmc Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    Matthew W Hulver
    Pennington Biomedical Research, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Cell Metab 2:251-61. 2005
    ..Herein, we show that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is robustly up-regulated in skeletal muscle from extremely obese humans...
  30. pmc The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 78:293-304. 2008
    ..The implications of age-related reductions in OFC PUFA composition for affective dysregulation in the elderly are discussed...
  31. doi Decreasing stearoyl-CoA desaturase-1 expression inhibits β-catenin signaling in breast cancer cells
    Daniel Mauvoisin
    BIOMED, Department of Biological Science, University of Quebec, Montreal, Canada
    Cancer Sci 104:36-42. 2013
    Stearoyl-CoA desaturase-1 (SCD1) is an endoplasmic reticulum anchored enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly palmytoleyl-CoA and oleyl-CoA...
  32. pmc High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients
    Ashley M Holder
    Department of Surgical Oncology, Unit 1484, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA
    Breast Cancer Res Treat 137:319-27. 2013
    Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. We have previously shown that overexpression of SCD1 increases the growth of breast cancer cell lines...
  33. doi Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma
    Yujian Zhang
    Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Cancer Sci 104:416-22. 2013
    ..Stearoyl-CoA desaturase-1 (SCD1) is the main isoform of SCDs, the rate-limiting enzymes in the biosynthesis of monounsaturated fatty acids from ..
  34. ncbi Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
    Kuninori Shiwaku
    Department of Environmental and Preventive Medicine, Shimane University School of Medicine, Izumo, Japan
    J Lipid Res 45:914-22. 2004
    ..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians...
  35. ncbi Prenatal and postnatal transfer of fatty acids from mother to pup in the hooded seal
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax
    J Comp Physiol B 165:1-12. 1995
    ..Ingested fatty acids were deposited directly and without modification into the blubber of pups, and by 4 days the fatty acid composition of pup blubber was virtually identical to that of the milk consumed...
  36. ncbi Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript
    C I Gonzalez
    Department of Biological Sciences and the Bureau of Biological Research, Nelson Laboratories, Piscataway, New Jersey 08855 1059, USA
    J Biol Chem 271:25801-9. 1996
    The Saccharomyces cerevisiae OLE1 gene encodes the Delta-9 fatty acid desaturase, a highly regulated integral membrane enzyme involved in the formation of unsaturated fatty acids from saturated acyl-coenzyme A precursors...
  37. ncbi The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    M Miyazaki
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 275:30132-8. 2000
    ..Two well characterized isoforms of SCD, SCD1 and SCD2, exist in the mouse...
  38. ncbi The regulation of stearoyl-CoA desaturase gene expression is tissue specific in chickens
    Sami Dridi
    Laboratory of Physiology, Immunology, and Genetics of Domestic Animals, Catholic University of Leuven, KU Leuven, 3001 Heverlee, Belgium
    J Endocrinol 192:229-36. 2007
    ..05). In conclusion, SCD is ubiquitously expressed in chickens and it is regulated by leptin, cerulenin, nutritional state, and gender in a tissue-specific manner...
  39. ncbi Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
    Hyoun ju Kim
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
    J Lipid Res 43:1750-7. 2002
    ..The mouse expresses three well-characterized SCD genes (SCD1, 2, and 3). SCD1 is the main isoform expressed in the liver of mice...
  40. ncbi A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes
    F Scott Heinemann
    Department of Pathology, Hoag Memorial Hospital Presbyterian, Newport Beach, California 92663, USA
    J Biol Chem 278:42966-75. 2003
    ..These findings indicate that SCD is degraded by a protease related to Pg and suggest that plasmin moonlights as an intracellular protease...
  41. ncbi Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
    J M Ntambi
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 263:17291-300. 1988
    ....
  42. ncbi A mathematical model for mammary fatty acid synthesis and triglyceride assembly: the role of stearoyl CoA desaturase (SCD)
    Paul R Shorten
    Mathematical Biology Group, AgResearch, Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand
    J Dairy Res 71:385-97. 2004
    ....
  43. doi Effects of feeding rapeseed oil, soybean oil, or linseed oil on stearoyl-CoA desaturase expression in the mammary gland of dairy cows
    A A A Jacobs
    Animal Nutrition Group, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    J Dairy Sci 94:874-87. 2011
    ..was to compare the effects of various fatty acids (FA) typically present in dairy cow rations on the expression of SCD1 and SCD5 in the mammary gland of dairy cows...
  44. ncbi Expression and regulation of delta5-desaturase, delta6-desaturase, stearoyl-coenzyme A (CoA) desaturase 1, and stearoyl-CoA desaturase 2 in rat testis
    Thomas Saether
    Andrology Laboratory, Department of Gynecology and Obstetrics, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Biol Reprod 69:117-24. 2003
    ..The focus of this study was to characterize the expression and regulation of stearoyl-CoA desaturase 1 (SCD1), stearoyl-CoA desaturase 2 (SCD2), and Delta5- and Delta6-desaturase in rat testis...
  45. doi Variation of Delta 9-desaturase activity in dairy cattle
    H Soyeurt
    Gembloux Agricultural University, Animal Science Unit, B 5030 Gembloux, Belgium
    J Dairy Sci 91:3211-24. 2008
    ..The positive genetic correlations observed between %MONO and the ratios of C14:1 cis-9 to C14:0 (0.72), C16:1 cis-9 to C16:0 (0.62), and C18:1 cis to C18:0 (0.97) showed that %MONO is linked to the Delta(9)-desaturase activity...
  46. pmc Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression
    C W Miller
    Department of Biochemistry, University of Wisconsin, Madison 53706, USA
    Proc Natl Acad Sci U S A 93:9443-8. 1996
    ..1983) Biochim. Biophys. Acta 752, 259-264]. We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome ..
  47. ncbi Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid
    M Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, 53706, USA
    J Nutr 131:2260-8. 2001
    ..Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice...
  48. pmc Glycosphingolipid fatty acid arrangement in phospholipid bilayers: cholesterol effects
    M R Morrow
    Department of Physics, Memorial University of Newfoundland, St John s, Canada
    Biophys J 68:179-86. 1995
    ....
  49. doi Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin
    Daniel Mauvoisin
    Departement des Sciences Biologiques, Centre de recherche BioMed, Universite du Quebec, Montreal, Canada
    Mol Cell Endocrinol 319:116-28. 2010
    Stearoyl-CoA Desaturase-1 (SCD1) is the rate limiting enzyme catalyzing the synthesis of monounsaturated fatty acids...
  50. ncbi Lipogenesis and stearoyl-CoA desaturase gene expression and enzyme activity in adipose tissue of short- and long-fed Angus and Wagyu steers fed corn- or hay-based diets
    K Y Chung
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Anim Sci 85:380-7. 2007
    ....
  51. ncbi beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis
    D Mainieri
    Department of Medicine Physiology, University of Fribourg, Fribourg, Switzerland
    Int J Obes (Lond) 31:378-81. 2007
    ..show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturase 1 (SCD1), which catalyzes the synthesis of monounsaturated fatty acids, show enhanced thermogenesis and high resistance to ..
  52. pmc Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
    Daniel Mauvoisin
    Departement des Sciences Biologiques, Centre de recherche BioMed, Universite du Quebec, C P 8888, Succursale Centre Ville, Montreal, Canada, H3C 3P8
    J Cell Commun Signal 1:113-25. 2007
    The stearoyl-CoA desaturase 1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids. This enzyme is a critical control point regulating hepatic lipogenesis and lipid oxidation...
  53. doi Effect of level and duration of dietary n-3 polyunsaturated fatty acid supplementation on the transcriptional regulation of Delta9-desaturase in muscle of beef cattle
    S M Waters
    Teagasc, Animal Bioscience Centre, Grange, Dunsany, Co Meath, Ireland
    J Anim Sci 87:244-52. 2009
    ....
  54. pmc Transport proteins and acute phase reactant proteins in children with sickle cell anemia
    R P Warrier
    Department of Pediatrics, Louisiana State University Medical Center, New Orleans 70112
    J Natl Med Assoc 86:33-9. 1994
    ..The implication of primary protein-energy malnutrition on growth retardation in SCD children is under study...
  55. ncbi Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase
    K H Kaestner
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 264:14755-61. 1989
    ..characterized a differentially expressed gene from mouse 3T3-L1 preadipocytes that encodes stearoyl-CoA desaturase (SCD1; Ntambi, J. M., Buhrow, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., Kelly, T. J., Jr., and Lane, M. D...
  56. ncbi Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol
    J M Ntambi
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 40:1549-58. 1999
    ..Two mouse and rat SCD genes (SCD1 and SCD2) and a single human SCD gene have been cloned and characterized...
  57. ncbi Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    Seong Ho Lee
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 45:1674-82. 2004
    ..Mice with a targeted disruption of the SCD1 isoform (SCD1-/-) exhibit reduced adiposity and increased energy expenditure...
  58. doi Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: possible role in amelioration of insulin resistance and hepatic steatosis
    Junji Yokozawa
    Department of Gastroenterology, Faculty of Medicine, Yamagata University, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Gastroenterol 44:583-91. 2009
    ..Stearoyl-CoA desaturase 1 (SCD-1), which catalyzes the cellular synthesis of monounsaturated fatty acids, affects lipid metabolism. In this study, we investigated whether SCD-1 gene expression is affected by ARB treatment...
  59. doi Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle
    G Conte
    Dipartimento di Agronomia e Gestione dell Agroecosistema, University of Pisa, 56124, Italy
    J Dairy Sci 93:753-63. 2010
    Several lipogenic genes have been shown to have effects on lipid metabolism: stearoyl CoA desaturase 1 (SCD1) catalyzes the desaturation of several fatty acids (FA) in the cis-Delta(9) position in mammary glands of ruminant animals, ..
  60. doi Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle
    T Matsuhashi
    Gifu Prefectural Livestock Research Institute, Kiyomi, Takayama, Gifu 506 0101, Japan
    J Anim Sci 89:12-22. 2011
    ..These results suggest that SNP in the FASN and SCD genes are useful markers for the improvement of fatty acid composition in commercial Japanese Black cattle...
  61. ncbi Corn oil supplementation to steers grazing endophyte-free tall fescue. II. Effects on longissimus muscle and subcutaneous adipose fatty acid composition and stearoyl-CoA desaturase activity and expression
    E Pavan
    Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA
    J Anim Sci 85:1731-40. 2007
    ..supplemental corn oil level to steers grazing endophyte-free tall fescue on fatty acid composition of LM, stearoyl CoA desaturase (SCD) activity and expression as well as cellularity in s.c. adipose...
  62. ncbi Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition
    Haiyan Xu
    Metabolic Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Front Biosci 12:3781-94. 2007
    ..Among the four mouse SCD isoforms, SCD1 is predominantly expressed in liver and adipose tissue...
  63. ncbi A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    M Miyazaki
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    J Lipid Res 42:1018-24. 2001
    ..The lipogenic diet fed to mice with a null mutation in the SCD1 gene (SCD-/-) fails to induce the synthesis of triglycerides in liver, despite the induction of expression of SREBP-..
  64. ncbi Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:25164-71. 2004
    ..Mice with a targeted disruption of the SCD1 gene are deficient in tissue oleate and have reduced expression of the sterol regulatory element-binding protein (..
  65. ncbi Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats
    Tomoaki Toyama
    Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama, Japan
    J Pharmacol Sci 103:383-90. 2007
    ..treatment with clofibric acid and the feeding of the fat-free diet caused an increase in the steady-state level of SCD1 mRNA and enhanced transcriptional rate...
  66. ncbi Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1
    F R Weiner
    Department of Medicine, Atran Laboratories, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 266:23525-8. 1991
    ..cells, we have studied the regulation of the expression of genes encoding acyl-CoA synthetase (ACS), and stearoyl CoA desaturase-1 (SCD-1), two enzymes that play key roles in the metabolism of long chain fatty acids...
  67. ncbi Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
    M Miyazaki
    Department of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 276:39455-61. 2001
    ..We found that the HG of the mice with a disruption in the gene for stearoyl-CoA desaturase 1 (SCD1) (SCD1-/-) is deficient in ADG...
  68. ncbi Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding
    Mary F F Chong
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:817-23. 2008
    ..High-carbohydrate (HC) diets increase de novo lipogenesis (DNL), but effects on stearoyl-CoA desaturase (SCD) are not so well studied...
  69. doi Acetyl-CoA carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content
    A Canovas
    IRTA, Genetica i Millora Animal, 191 Rovira Roure, 25198 Lleida, Spain
    J Anim Sci 87:3905-14. 2009
    ..48, P < 0.05). Intramuscular fat content did not correlate with ACC or Delta6d protein expression (P = 0.23 and P = 0.80, respectively). We conclude that SCD might be an effective potential biomarker for intramuscular fat deposition...
  70. pmc Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
    Marcia L E MacDonald
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, BC, Canada V5Z 4H4
    Biochim Biophys Acta 1791:1166-72. 2009
    Absence of stearoyl-CoA desaturase-1 (SCD1) in mice leads to chronic inflammation of the skin and increased susceptibility to atherosclerosis, while also increasing plasma inflammatory markers...
  71. pmc Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target
    Paul Gratraud
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, Case 107, Montpellier, France
    PLoS ONE 4:e6889. 2009
    ..How parasites acquire this monounsaturated fatty acid has remained enigmatic. Here, we report on the biochemical and enzymatic characterization of stearoyl-CoA desaturase (SCD) in P. falciparum...
  72. pmc Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance
    Eva Warensjo
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
    Lipids Health Dis 8:37. 2009
    ..D5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations...
  73. doi Cloning and expression of stearoyl-CoA desaturase 1 (SCD-1) in the liver of the Sichuan white goose and landes goose responding to overfeeding
    Zhi Xiong Pan
    Key Lab of Animal Genetic Resources, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, Sichuan 625014, People s Republic of China
    Mol Biol Rep 38:3417-25. 2011
    ..In conclusion, SCD-1 is not only critical for hepatic steatosis in geese but is also important for the difference in lipid deposition in the livers of the two breeds...
  74. ncbi Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse
    Makoto Miyazaki
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA
    J Lipid Res 43:2146-54. 2002
    ..We have found that the mouse PG expresses the three gene isoforms (SCD1, SCD2, and SCD3) of the Delta9 stearoyl-CoA desaturase enzyme that catalyzes the biosynthesis of monounsaturated ..
  75. ncbi Recent insights into stearoyl-CoA desaturase-1
    James M Ntambi
    Departments of Biochemistry and Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 14:255-61. 2003
    ..Why, then, is stearoyl-CoA desaturase a highly regulated enzyme? This review summarizes the recent and timely advances concerning the important role of stearoyl-CoA desaturase in metabolism...
  76. ncbi Regulation of stearoyl-CoA desaturases and role in metabolism
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Prog Lipid Res 43:91-104. 2004
    ..Several SCD gene isoforms (SCD1, SCD2, SCD3) exist in the mouse and one SCD isoform that is highly homologous to the mouse SCD1 is well ..
  77. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes ..
  78. ncbi Isolation and molecular characterization of the porcine stearoyl-CoA desaturase gene
    Jun Ren
    Institute of Veterinary Medicine, Georg August University of Gottingen, Groner Landstrasse 2, Gottingen 37073, Germany
    Gene 340:19-30. 2004
    ..Reverse transcription (RT)-PCR result indicates that the SCD gene is expressed ubiquitously in pigs...
  79. ncbi Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation
    A Dobrzyn
    Department of Physiology, Medical University of Białystok, Białystok, Poland
    J Physiol Pharmacol 57:31-42. 2006
    ..b>SCD1 deficient mice reveal increased energy expenditure and decreased body adiposity due to the upregulation of genes of ..
  80. pmc Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells
    Xiaomei Qin
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, 100083, PR China
    Cardiovasc Res 74:506-14. 2007
    ..Stearoyl-CoA desaturase-1 (SCD1), which catalyzes the biosynthesis of monounsaturated fatty acids, affects the lipid composition and fluidity of ..
  81. ncbi Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
    Jennifer L Christianson
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Biol Chem 283:2906-16. 2008
    ..of adipocyte-specific gene expression in fully differentiated 3T3-L1 adipocytes, including the expression of SCD1. Despite the high sequence similarity between SCD2 and SCD1, silencing of SCD1 did not down-regulate 3T3-L1 cell ..
  82. ncbi Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 294:E357-64. 2008
    ..Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes the synthesis of monounsaturated fatty acids (FA). SCD1 deficiency activates metabolic pathways that promote FA beta-oxidation and decrease lipogenesis in liver...
  83. pmc A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men
    H Melhus
    Department of Medical Sciences, University Hospital, Entrance 61, 4th Floor, SE 751 85, Uppsala, Sweden
    Osteoporos Int 19:929-34. 2008
    ..This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis...
  84. ncbi Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
    François Paillard
    Cardiovascular Prevention Center, Departement de Cardiologie, CHU Pontchaillou, 2 rue Henri Le Guilloux, 35033 Rennes, France
    Nutr Metab Cardiovasc Dis 18:436-40. 2008
    ..The aim was to assess the relationship of plasma palmitoleic acid content, a product of SCD activity, with triglyceridemia and abdominal adiposity in humans...
  85. doi Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity
    Roslyn Dillon
    Pfizer Global Research, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA 92121, United States
    Anal Chim Acta 627:99-104. 2008
    Stearoyl-CoA desaturase 1 (SCD1) is an enzyme that catalyzes the rate-limiting step in de novo synthesis of monounsaturated fatty acids--mainly oleate and palmitoleate from stearoyl-CoA and palmitoyl-Co A, respectively...
  86. pmc Biochemical and physiological function of stearoyl-CoA desaturase
    Chad M Paton
    Department of Biochemistry, University of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 297:E28-37. 2009
    ..In this article, we summarize the recent and timely advances concerning the important role of SCD in the biochemistry and physiology of lipid metabolism...
  87. pmc Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:19961-73. 2009
    Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids and is an important regulator of whole body energy homeostasis...
  88. doi Detection of quantitative trait loci affecting the milk fatty acid profile on sheep chromosome 22: role of the stearoyl-CoA desaturase gene in Spanish Churra sheep
    M Garcia-Fernandez
    Departamento de Produccion Animal, Facultad de Veterinaria, Universidad de Leon, 24071 Leon, Spain
    J Dairy Sci 93:348-57. 2010
    ..An independent confirmation of these primary results will be required before attempting its practical implementation in selection programs...
  89. doi Novel SNPs in the caprine stearoyl-CoA desaturase (SCD) and decorin (DCN) genes that are associated with growth traits in Chinese goat breeds
    Zhongqi Chen
    College of Animal Science and Technology, Northwest A and F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, No 22 Xinong Road, Yangling, 712100 Shaanxi, China
    Mol Biol Rep 38:3121-7. 2011
    ..05). These results indicated that genotype CC of SCD gene and genotype XX of DCN gene could be used for the breeding of new breeds of goat in China...
  90. doi Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1
    Pawel Dobrzyn
    Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology, 3 Pasteur St, 02 093 Warsaw, Poland
    J Appl Physiol (1985) 109:1653-61. 2010
    ..Herein, we demonstrate that endurance training significantly increases both SCD1 mRNA and protein levels in the soleus muscle, whereas it does not affect SCD1 expression in the EDL muscle and ..
  91. pmc Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
    Roger Gutierrez-Juarez
    Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Invest 116:1686-95. 2006
    Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids from saturated fatty acids. Mice with a targeted disruption of Scd1 gene locus are lean and display increased insulin sensitivity...
  92. ncbi Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation
    M V Singh
    Department of Biochemistry, University of Wisconsin Madison 53706, USA
    Biochim Biophys Acta 1398:148-56. 1998
    b>Stearoyl CoA desaturase gene 1 (SCD1) is a delta 9 desaturase that is transcriptionally activated during the differentiation of 3T3-L1 preadipocytes into adipocytes...
  93. ncbi Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    Y Zheng
    Johnson and Johnson Skin Biology TRC, Grandview Road, Skillman, New Jersey 08558, USA
    Genomics 71:182-91. 2001
    ..Previously, two members of this gene family, namely, Scd1 and Scd2, have been reported...
  94. ncbi Identification and characterization of hamster stearoyl-CoA desaturase isoforms
    Jian Wang
    Cardiovascular and Diabetes Drug Discovery, Lilly Research Labs, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Lipids 43:197-205. 2008
    ..It plays a key role in lipid metabolism and energy expenditure in mammals. In mice, four SCD isoforms (SCD1-4) have been identified...
  95. ncbi Hearing loss in children with sickle cell disease
    A Koussi
    1st Department of Pediatrics, Thalassaemia Unit, Aristotle University of Thessaloniki, Greece
    Acta Otorhinolaryngol Belg 55:235-9. 2001
    ..No abnormalities were detected in the control group. These findings suggest a low incidence of SNHL in Greek SCD patients probably due to different hematological and clinical profile (S/beta(+)-Thal)...
  96. ncbi [Basic study of Beutin's washed sheep blood agar plate used for selective screening of verocytotoxin-producing/enterohemorrhagic Escherichia coli (VTEC/EHEC)]
    N Kimura
    Ishikawa Health Service Association
    Kansenshogaku Zasshi 73:318-27. 1999
    ..Center) washed five times in phosphate-buffered saline, pH 7.2...
  97. pmc Helicobacter pylori infection in sickle cell disease
    K F Woods
    Department of Medicine, Medical College of Georgia, Augusta 30912, USA
    J Natl Med Assoc 92:361-5. 2000
    ..When confirmed, a definitive etiology of PUD must be determined so that appropriate treatment strategies can be initiated promptly and excess morbidity avoided...
  98. pmc High pressure 2H-NMR study of the order and dynamics of selectively deuterated dipalmitoyl phosphatidylcholine in multilamellar aqueous dispersions
    X Peng
    Department of Chemistry, School of Chemical Sciences, University of Illinois, Urbana 61801, USA
    Biophys J 68:1137-44. 1995
    ..In addition we found a straight line relationship for T-1 vs. S2D, and T-1 vs. S2CD for the deuterons in the 9 and 13 positions in the LC phase in the pressure range investigated...
  99. pmc Tumor necrosis factor alpha in children with sickle cell disease in stable condition
    S Kuvibidila
    Department of Pediatrics, Louisiana State University, School of Medicine, New Orleans 70112, USA
    J Natl Med Assoc 89:609-15. 1997
    ..These results indicate that most children with SCD in stable condition have normal TNF-alpha concentrations and that those with high TNF-alpha levels are more likely to have growth deficits...
  100. pmc Glycosphingolipid acyl chain orientational order in unsaturated phosphatidylcholine bilayers
    M R Morrow
    Department of Physics, Memorial University of Newfoundland, St John s, Canada
    Biophys J 64:654-64. 1993
    ....
  101. ncbi Application of capillary ion electrophoresis and ion chromatography for the determination of O-acetate groups in bacterial polysaccharides
    R W Hepler
    Department of Virus and Cell Biology, Merck Research Laboratories, West Point, PA 19486
    J Chromatogr A 680:201-8. 1994
    ..5 mM tetradecyltrimethylammonium bromide, and 2 mM sodium tetraborate, pH 5.88. A comparison of CIE and IC-SCD in terms of reproducibility, accuracy, linearity, and sensitivity will be presented...

Research Grants79

  1. Primary Prevention of Strokes in Nigerian Children with Sickle Cell Disease
    LORI CHAFFIN JORDAN; Fiscal Year: 2013
    ....
  2. Beta-Globin Gene Correction Using Peptide Nucleic Acids for the Treatment of Sick
    GERALD FRANCIS VOVIS; Fiscal Year: 2010
    ..Helix Therapeutics is proposing to develop a therapeutic gene targeting agent to correct, in human hematopoietic stem cells, the mutation responsible for causing SCD and, thus, cure the disease permanently. ..
  3. Thomas W Glover; Fiscal Year: 2016
    ..Moreover they will have important and immediate clinical significance to a large number of individuals with SCD and the future generations of HU-treated patients. ..
  4. Peter G Vekilov; Fiscal Year: 2016
    ..We plan to disseminate our models, software tools, and experimental data including the general-purpose triple-decker algorithm, via web-based repositories, existing public open-ware sites, tutorials and through the MSM consortium. ..
  5. JOSHUA JEFFREY FIELD; Fiscal Year: 2016
    ..If this study provides preliminary evidence that montelukast when combined with HU has efficacy for the treatment of vaso-occlusion, we will propose a larger multi-center phase III trial. ..
  6. Educational Attainment in Sickle Cell Disease
    Allison A King; Fiscal Year: 2010
    ..The knowledge and skills acquired from completing these studies will allow the applicant to develop evidence based strategies to improve educational attainment in students with SCD. ..
  7. SOPHIE M LANZKRON; Fiscal Year: 2014
    ....
  8. Enrico M Novelli; Fiscal Year: 2016
    ..Jeff Isenberg's lab). Definition of this pathway will therefore present a novel therapeutic target for the vascular complications of SCD. ..
  9. Protein biomarkers of pulmonary hypertension in sickle cell disease
    Mark E McComb; Fiscal Year: 2013
    ....
  10. Mitchell S Cairo; Fiscal Year: 2015
    ..abstract_text> ..
  11. Donna S Neuberg; Fiscal Year: 2016
    ..We will study a drug called regadenoson in people with sickle cell disease to determine if it is an effective treatment for pain or acute chest syndrome episodes. ..
  12. Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell Anemia
    THOMAS DUANE COATES; Fiscal Year: 2011
    ..Aim 3 will be done in collaboration with the randomized glutamine trial proposed in Project 2B (PI:Niihara). ..
  13. Asthma and Nocturnal Hypoxemia in Sickle Cell Anemia II
    Robert Strunk; Fiscal Year: 2013
    ..The overall goal of this applications is to identify the laboratory and clinical determinants of how lung disease progresses from normal in early childhood to asthma and later to a severe lung disease that requires oxygen ..
  14. JEAN LECLERC RAPHAEL; Fiscal Year: 2015
    ....
  15. Prevention of Stroke after STOP, A Retrospective Chart Review
    Robert J Adams; Fiscal Year: 2012
    ..Overall the project provides substantial new information that will insure the major investment made in STOP and STOP II is used to best advantage in real world applications to prevent stroke in children with SCD. ..
  16. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..Stearoyl-CoA desaturase- 1 (SCD1) is increased in obesity and catalyzes the conversion of saturated fatty acids (16:0 and 18:0) to mono- unsaturated ..
  17. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Overall, our research proposal may help in designing oleate-rich dietary formulations and also clarify whether SCD-1 can be targeted to prevent colitis and metabolic diseases ! ..
  18. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..also thought to mediate the repressive effects of unsaturated FA on the expression of stearoyl-CoA desaturase 1 (SCD1), an enzyme that catalyzes endogenous synthesis of OA...
  19. Genetics of Obesity in Yup'ik Eskimos
    BERT BRANDON BOYER; Fiscal Year: 2011
    ..investigation: adiponectin (3q27), AMP kinase gamma 2 subunit and nuclear respiratory factor-1 (7q36), stearoyl CoA desaturase (10q23), sterol regulatory element binding protein (17p11), insulin sensitive glucose transporter (17p13),..
  20. A Heather Eliassen; Fiscal Year: 2015
    ..k.a. stearoyl-CoA desaturase 1 (SCD1)), measured by the ratio of specific saturated to monounsaturated fatty acids, (saturation index (SI)n-7 and SIn-9)...
  21. Robert K McNamara; Fiscal Year: 2016
    ....
  22. Regulation of stearoyl-CoA desaturases by oleate
    Douglas Thewke; Fiscal Year: 2004
    ..inhibits SCO activity in CHO fibroblasts, represses the mRNA levels and transcription of the two known SCD genes, SCD1 and SCD2...
  23. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..our second series of studies, we will place mice with an adipose tissue-specific deletion of the gene for stearoyl CoA desaturase 1 (SCD1) on MR to determine if an inhibition of the synthesis of fats reduces metabolism in adipose ..
  24. Inflammatory regulation of lipid accumulation in skeletal muscle with obesity
    Matthew W Hulver; Fiscal Year: 2012
    ..The PI and colleagues recently demonstrated that SCD1 in skeletal muscle is a core mechanism contributing to reduced fatty acid (FA) oxidation and increased ..
  25. Role of Early B Cell Factor-1 (EBF-1) in Adipocyte Biology
    Michael J Griffin; Fiscal Year: 2010
    ....
  26. Effect of Pre and Postnatal Nutritional Programming on SCD1 Activity and Obesity
    Jennifer K Yee; Fiscal Year: 2011
    ..at Harbor-UCLA establishing her academic career studying the role of stearoyl-CoA desaturase enzyme-1 (SCD1) and fatty acid synthesis pathways in nutritional programming for obesity. As a fellow, Dr...
  27. Makoto Miyazaki; Fiscal Year: 2016
    ..As shown in our preliminary results, increasing stearate by adding exogenous stearate or by inhibiting SCD1 and SCD2 augmented vascular calcification in vitro and in vivo...
  28. Inducible Tissue-Specific Transgene Expression in Large Animal Biomedical Models
    Charles R Long; Fiscal Year: 2011
    ..Our project will develop the technology to reliably induce tissue-specific expression of genes so that disease states can be mimicked in non-rodent species. ..
  29. Charles R Long; Fiscal Year: 2014
    ....
  30. Formulation and Standardization of a Sickle Cell Disease Drug for Clinical Trial
    Robert Swift; Fiscal Year: 2010
    ..Treatment options are few. There is a substantial unmet medical need for new safe and effective disease modifying drugs, like the one in this grant, to treat this disease. ..
  31. Harvey J Murff; Fiscal Year: 2014
    ..that up to 28% of the additive variance in tissue levels of ARA is explained by variants in a single gene, fatty acid desaturase 1 (FADS1)...
  32. Bo Qiu; Fiscal Year: 2015
    ..regulates essential genes mediating mitophagy (NIX) and de novo lipogenesis (SREBF1, ACLY, ACACB, FASN, SCD1)...
  33. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Findings of this study may provide important information that could shape dietary recommendations to prevent coronary events. ..
  34. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  35. JAMES T BRENNA; Fiscal Year: 2016
    ..LCPUFA biosynthesis is limited by desaturase activity encoded by the fatty acid desaturase gene cluster (FADS1-3, 11q12-13.1)...
  36. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ....
  37. Floyd H Chilton; Fiscal Year: 2014
    ..of PUFA-based botanical dietary supplements is strongly associated with genetic polymorphisms in the fatty acid desaturase (FADS 1-3) cluster on chromosome 11 in a region known as 11q12-q13...
  38. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..Specifically, NINDS support is for the expansion of the case ascertainment to include cases of SUDEP in individuals under the age of 24 in up to 15 states. ..
  39. Prognostic Impact and Arrhythmic Potential of Peri-infarct Zone by Cardiac MRI
    Raymond Y Kwong; Fiscal Year: 2012
    ..abstract_text> ..
  40. Role of fatty acid metabolism for the prevention of sudden cardiac death
    STEPHANIE ELIZABETH CHIUVE; Fiscal Year: 2011
    ..This proposal is relevant to the NHLBI's strategic plan which aims "to develop non-invasive techniques, such as biological markers, to clinically identify patients at high risk of SCD". ..
  41. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  42. Kalyanam Shivkumar; Fiscal Year: 2016
    ..Therefore, neuraxial modulation is an approach that has the potential to have a global impact given the prohibitive high cost and morbidity associated with implantable defibrillators which prevent their expanded use. ..
  43. STEPHANIE ELIZABETH CHIUVE; Fiscal Year: 2015
    ..These aims correspond to one goal in the NHLBl's strategic plan to "develop means to predict and prevent sudden cardiac death". ..
  44. The Genetic Basis of Novel Loci Influencing Myocardial Repolarization
    David J Milan; Fiscal Year: 2010
    ....
  45. Comparative effectiveness of ECG screening in children with Attention Deficit Hyp
    Laurel K Leslie; Fiscal Year: 2010
    ..In this application, we propose to apply three up-to-date methodologies - evidence-based synthesis, decision analysis, and preference elicitation - to address this pressing clinical and public policy issue. ..
  46. Reactivation of Fetal Gamma-globin Genes for the Treatment of Beta-globin Disorde
    Osamu Tanabe; Fiscal Year: 2010
    ..abstract_text> ..
  47. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
    ....
  48. Elucidation of Antisickling Molecules in a Botanical with Antisickling Activity
    Robert Swift; Fiscal Year: 2013
    ..The active fractions will be further fractionated, the compounds in the sub-fractions identified using mass spectroscopy and NMR, and in vivo activity confirmed in 100% human Hb S transgenic mice. ..
  49. First Clinical Trial of an Anti-Sickling Botanical Drug for Sickle Cell Dise
    Robert Swift; Fiscal Year: 2013
    ....
  50. Luanne L Peters; Fiscal Year: 2016
    ..WT erythroid cells will converge to identify novel regulators of [unreadable]- like globin switching, thereby providing important new therapeutic targets for the hemoglobinopathies. ! ..
  51. Wally R Smith; Fiscal Year: 2016
    ....
  52. Inactivation of LSD1 as a possible treatment for sickle cell disease
    James Douglas Engel; Fiscal Year: 2013
    ..Should these preliminary tests be fruitful, we will in the future then initiate clinical trials in ealthy and sickle cell patients. ..
  53. Sickle Cell Disease: First steps toward understanding barriers to care for adults
    SOPHIE M LANZKRON; Fiscal Year: 2012
    ..She has selected mentors in behavioral research, epidemiology and sickle cell that provide the necessary supervision to make her a successful independent investigator. ..
  54. CTRIP: Treatment of Sickle Cell Crisis with inhibitors of NKT cell activation
    DAVID G contact NATHAN; Fiscal Year: 2010
    ..It causes short life span, pain and multi-organ failure. We have discovered a new anti-inflammatory approach to effectively treat SCD in mice and we plan to evaluate this new therapy in patients with SCD. ..
  55. NCMHD Southeastern Exploratory Sickle Cell Center of Excellence
    Abdullah Kutlar; Fiscal Year: 2013
    ..Relieving the health disparity of SCD patients is the primary goal of this application. ..
  56. Michael R Debaun; Fiscal Year: 2014
    ..In doing so, this study could also reduce the burden of chronic transfusions and change clinical practice by broadening the indications for HU. ..
  57. COMPREHENSIVE SICKLE CELL CENTER
    Kwaku Ohene Frempong; Fiscal Year: 2010
    ..We plan to continue our commitment to extend benefits of research to less developed areas of the sickle cell world. ..
  58. Arlene M Smaldone; Fiscal Year: 2014
    ..This research may also inform interventions for other pediatric chronic illnesses in underserved communities. ..
  59. BABY HUG FOLLOW-UP STUDY II )
    Bruce Thompson; Fiscal Year: 2012
    ..In collaboration with the NICHD under the Best Pharmaceuticals for Children Act (BPCA) NHLBI, as the IND sponsor, will submit clinical data to the Food and Drug Administration (FDA) to seek pediatric use labeling for HU. ..
  60. BASE FUNDING NHLBI (1/10/2012 - 12/31/2016) BABY HUG FOLLOW-UP STUDY II - CLIN
    Ofelia Alvarez; Fiscal Year: 2012
    ..In collaboration with the NICHD under the Best Pharmaceuticals for Children Act (BPCA) NHLBI, as the IND sponsor, will submit clinical data to the Food and Drug Administration (FDA) to seek pediatric use labeling for HU. ..
  61. BABY HUG FOLLOW-UP STUDY II: SUNY CLINICAL SITE
    Scott Miller; Fiscal Year: 2012
    ..In collaboration with the NICHD under the Best Pharmaceuticals for Children Act (BPCA) NHLBI, as the IND sponsor, will submit clinical data to the Food and Drug Administration (FDA) to seek pediatric use labeling for HU. ..
  62. Lai Hua Xie; Fiscal Year: 2015
    ....
  63. Reducing the Toxicity of BMT in Sickle Cell Anemia
    Robert Iannone; Fiscal Year: 2004
    ..As part of my training, I will obtain a Master's Degree in Clinical Research through the Center for Clinical Epidemiology and Biostatistics. ..
  64. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..Studies in the previous grant application demonstrated that mice with a targeted disruption of SCD1 isoform (SCD1-/-) have reduced lipogenic gene expression, increased fatty acid oxidation and enhanced insulin ..
  65. Targeted cell therapy for the treatment of ventricular tachycardia
    KENNETH LAURITA; Fiscal Year: 2010
    ..Consequently, SCD remains a major unresolved public health problem. This proposal puts forth a novel method using targeted cellular therapy to restore normal function and, thus, cure many patients at risk for SCD. 1 ..
  66. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  67. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ....
  68. Identifying Strategies to Increase Engagement in Clinical Trials in Pediatric SCD
    Lamia P Barakat; Fiscal Year: 2010
    ....
  69. PSYCHOSOCIAL FACTORS IN SUDDEN CARDIAC DEATH
    Sue Thomas; Fiscal Year: 2002
    ..The combination of data from PFOS and SCD-HeFT will provide a holistic assessment of HF patients. ..
  70. Sudden Cardiac Death in Heart Failure Trial 10 year Follow-up (SCD-HeFT 10 yr.)
    Gust H Bardy; Fiscal Year: 2010
    ....