SSTR5

Summary

Gene Symbol: SSTR5
Description: somatostatin receptor 5
Alias: SS-5-R, somatostatin receptor type 5, somatostatin receptor subtype 5
Species: human

Top Publications

  1. ncbi C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest
    K Sharma
    Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Endocrinol 13:82-90. 1999
  2. ncbi Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers
    M Rocheville
    Fraser Laboratories, Departments of Medicine, Pharmacology and Therapeutics, and Neurology and Neurosurgery, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 275:7862-9. 2000
  3. ncbi Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly
    M Filopanti
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Istituto di Ricovero e Cura a Curattere Scientifico, Milan, Italy
    J Clin Endocrinol Metab 90:4824-8. 2005
  4. doi Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling
    Geetanjali Kharmate
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3
    Biochim Biophys Acta 1813:1172-89. 2011
  5. doi Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells
    Heather L Watt
    Faculty of Medicine, Department of Experimental Medicine, McGill University, Royal Victoria Hospital, Montreal, QC, Canada
    Cell Signal 21:428-39. 2009
  6. doi Receptor specific crosstalk and modulation of signaling upon heterodimerization between β1-adrenergic receptor and somatostatin receptor-5
    Rishi K Somvanshi
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, BC, Canada
    Cell Signal 23:794-811. 2011
  7. ncbi Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines
    K B Ain
    Thyroid Cancer Research Laboratory, Medical Service, Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA
    J Clin Endocrinol Metab 82:1857-62. 1997
  8. ncbi Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity
    M Rocheville
    Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    Science 288:154-7. 2000
  9. ncbi Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder
    M Nyegaard
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Denmark
    Mol Psychiatry 7:745-54. 2002
  10. doi A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs
    Mario Duran-Prado
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, E 14014 Cordoba, Spain
    J Clin Endocrinol Metab 95:2497-502. 2010

Research Grants

  1. PHARMACOLOGY OF SOMATOSTATIN RECEPTORS
    Jean Rivier; Fiscal Year: 1999
  2. Regulation of Mouse Somatostatin Receptor Subtype 5 Gene
    WHITNEY WOODMANSEE; Fiscal Year: 2004
  3. Intraislet Communication in Surgically-Altered Pancreas
    FRANCIS BRUNICARDI; Fiscal Year: 2007
  4. Somatostatin Receptor Subtype 5 Regulation of Islet Neoplasia
    FRANCIS CHARLES BRUNICARDI; Fiscal Year: 2010
  5. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
  6. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008

Detail Information

Publications190 found, 100 shown here

  1. ncbi C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest
    K Sharma
    Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Endocrinol 13:82-90. 1999
    ..These data demonstrate that the C-terminal domain of hSSTR5 is required for cytostatic signaling that is PTP dependent and leads to induction of hypophosphorylated Rb and G1 arrest...
  2. ncbi Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers
    M Rocheville
    Fraser Laboratories, Departments of Medicine, Pharmacology and Therapeutics, and Neurology and Neurosurgery, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 275:7862-9. 2000
    ..Double label confocal fluorescence microscopy showed that when SSTR1 and SSTR5 subtypes were coexpressed in Chinese hamster ovary-K1 cells and treated with agonist they underwent ..
  3. ncbi Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly
    M Filopanti
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Istituto di Ricovero e Cura a Curattere Scientifico, Milan, Italy
    J Clin Endocrinol Metab 90:4824-8. 2005
    The aim of the study was to investigate the possible correlation of single nucleotide polymorphisms in somatostatin receptor (SSTR)2 and SSTR5 genes with the responsiveness to somatostatin analogs in a cohort of acromegalic patients.
  4. doi Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling
    Geetanjali Kharmate
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3
    Biochim Biophys Acta 1813:1172-89. 2011
    ..We propose that the activation of SSTR and blockade of EGFR might serve novel therapeutic approach in inhibition of tumor proliferation...
  5. doi Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells
    Heather L Watt
    Faculty of Medicine, Department of Experimental Medicine, McGill University, Royal Victoria Hospital, Montreal, QC, Canada
    Cell Signal 21:428-39. 2009
    ..oestrogen receptor (ER)-positive (MCF-7) or ERalpha-negative (MDA-MB-231) breast cancer cells, we defined SSTR1, SSTR5 and ErbB1 mRNA and protein expression in these two tumour cell lines...
  6. doi Receptor specific crosstalk and modulation of signaling upon heterodimerization between β1-adrenergic receptor and somatostatin receptor-5
    Rishi K Somvanshi
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, BC, Canada
    Cell Signal 23:794-811. 2011
    ..dephosphorylation and nuclear translocation of NFAT, the process predominantly regulated by pJNK in SSTR5 dependent manner...
  7. ncbi Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines
    K B Ain
    Thyroid Cancer Research Laboratory, Medical Service, Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA
    J Clin Endocrinol Metab 82:1857-62. 1997
    ..Most thyroid cancer cell line monolayers and xenografts expressed SSTR3 and SSTR5 mRNAs...
  8. ncbi Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity
    M Rocheville
    Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    Science 288:154-7. 2000
    ..Here, we show that dopamine receptor D2R and somatostatin receptor SSTR5 interact physically through hetero-oligomerization to create a novel receptor with enhanced functional activity...
  9. ncbi Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder
    M Nyegaard
    Department of Clinical Biochemistry and Genetics, Odense University Hospital, Denmark
    Mol Psychiatry 7:745-54. 2002
    The somatostatin receptor 5 (SSTR5) gene is a candidate gene for bipolar affective disorder (BPAD) as well as for other neuropsychiatric disorders. The gene is positioned on chromosome 16p13...
  10. doi A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs
    Mario Duran-Prado
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, E 14014 Cordoba, Spain
    J Clin Endocrinol Metab 95:2497-502. 2010
    ..Recently we identified two novel truncated sst5 variants, sst5TMD5, and sst5TMD4, absent in normal pituitary but expressed in pituitary tumors...
  11. ncbi Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization
    J Takeda
    Department of Medicine, Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Genomics 26:638-9. 1995
  12. ncbi Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28
    R Panetta
    Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Pharmacol 45:417-27. 1994
    ..library screening we have cloned a human gene for a subtype of the somatostatin (SST) receptor (SSTR) termed human SSTR5 (hSSTR5), which is located on chromosome 16...
  13. ncbi Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
    Biochem Biophys Res Commun 195:844-52. 1993
    ..These results suggest that diverse actions of somatostatin are mediated by at least five somatostatin receptor subtypes with potentially different function...
  14. ncbi Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment
    E Ballare
    Institute of Endocrine Sciences, University of Milano 20122, Ospedale Maggiore IRCCS, 20122 Milan, Italy
    J Clin Endocrinol Metab 86:3809-14. 2001
    ..We suggest that this mutation that abrogates the antiproliferative action of somatostatin and activates mitogenic pathways may be involved in the resistance to somatostatin treatment...
  15. ncbi Somatostatin (SRIF) receptor subtype 2 and 5 gene expression in growth hormone-secreting pituitary adenomas: the relationship with endogenous srif activity and response to octreotide
    Cheolyoung Park
    Department of Internal Medicine, College of Medicine, Hallym University, Kyunggi, Korea
    Endocr J 51:227-36. 2004
    ..However, sst2 and sst5 mRNA levels are not the only factors mediating the response to SRIF...
  16. doi Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors
    Mario Duran-Prado
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, and Centro de Investigacion Biomedica en Red Fisiopatología de la Obesidad y Nutrición, E 14014 Córdoba Spain
    J Clin Endocrinol Metab 94:2634-43. 2009
    ..Despite the considerable advances in the knowledge on these receptors and their (patho)physiological roles, there is still evidence that additional receptors for these peptides should exist to fully explain their actions...
  17. doi Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions
    Alessandro Fasciani
    Ospedali Galliera, Genova, Italy
    J Clin Endocrinol Metab 95:5315-9. 2010
    ..Five subtypes of somatostatin receptors have been identified, and the therapeutic use of somatostatin receptor-selective agonists has been reported in several diseases...
  18. pmc The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function
    Guisheng Zhou
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    World J Surg 35:1715-24. 2011
    b>Somatostatin receptor subtype 5 (SSTR5) mediates the inhibitory effect of somatostatin on insulin expression/secretion and cell proliferation...
  19. pmc Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:2863-72. 2011
    ..Genetic variation in SSTR had been associated with risk of human cancers but had never been investigated in pancreatic cancer...
  20. ncbi The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization
    N Hukovic
    Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital and the Montreal Neurological Institute, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 273:21416-22. 1998
    We have investigated the role of the cytoplasmic tail (C-tail) of the human somatostatin receptor type 5 (hSSTR5) in regulating receptor coupling to adenylyl cyclase (AC) and in mediating agonist-dependent desensitization and ..
  21. ncbi BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide
    P Jaquet
    Interactions Cellulaires Neuroendocriniennes, UMR6544, Centre National de la Recherche Scientifique, Institut Federatif Jean Roche, Faculte de Medecine Nord, Marseille, France
    J Endocrinol Invest 28:21-7. 2005
    We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes (SSTR2 and SSTR5), and dopamine D2 (DAD2) compound, BIM-23A760, in suppressing GH secretion, in cell culture from human GH-secreting tumors, from patients ..
  22. ncbi Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion
    Anat Ben-Shlomo
    Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, California 90048, USA
    J Biol Chem 280:24011-21. 2005
    ..To assess the contribution of somatostatin receptor subtype 5 (SST5) to somatostatin receptor subtype 2 (SST2) action in these cells, we assessed multipathway ..
  23. ncbi Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3
    K Sharma
    Fraser Laboratories for Diabetes Research McGill University and Royal Victoria Hospital Montreal, Quebec, Canada
    Mol Endocrinol 10:1688-96. 1996
    ..been reported to follow stimulation of protein tyrosine phosphatase via SSTR2 or inhibition of Ca2+ channels via SSTR5 in heterologous expression systems, the subtype selectivity for signaling apoptosis has not been investigated...
  24. ncbi Characterization of somatostatin receptor subtype-specific regulation of insulin and glucagon secretion: an in vitro study on isolated human pancreatic islets
    Vandana Singh
    Medizinische Klinik m S Hepatologie, Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    J Clin Endocrinol Metab 92:673-80. 2007
    ..Five pharmacologically distinct SSTR subtypes are known (SSTR1-SSTR5). In rodents, SSTR2 inhibits glucagon secretion, whereas SSTR5 suppresses the release of insulin...
  25. ncbi Cloning, expression, pharmacology and tissue distribution of the mouse somatostatin receptor subtype 5
    H Baumeister
    Abteilung Molekulare Genetik, Deutsches Institut für Ernährungsforschung, Potsdam, Germany
    J Neuroendocrinol 10:283-90. 1998
    The gene encoding the mouse somatostatin receptor subtype 5 has been isolated from a genomic library and the mRNA start point mapped to position -95 relative to the translational start codon...
  26. ncbi Oestrogen-mediated regulation of somatostatin receptor expression in human breast cancer cell lines assessed with 99mTc-depreotide
    B Van Den Bossche
    Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000B, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 31:1022-30. 2004
    ..Both SSTR2 and SSTR5 were expressed at high levels in T47D cells and ZR75-1 cells...
  27. ncbi Immunohistochemical expression and localization of somatostatin receptor subtypes in prostate cancer with neuroendocrine differentiation
    D Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Int J Immunopathol Pharmacol 23:511-22. 2010
    ..groups; in the latter two, the mean percentages were similar; and (iii) Nuclear staining was seen with SSTR4 and SSTR5; for SSTR4, the mean percentages in the PCa of the three groups were higher than in HGPIN and Nep, the highest ..
  28. ncbi Somatostatin receptors in pituitary and development of somatostatin receptor subtype-selective analogs
    Ilan Shimon
    Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Endocrine 20:265-9. 2003
    Somatostatin receptor (SSTR) subtypes 1, 2, and 5 are expressed in the normal human pituitary. SSTR2 and SSTR5 are expressed in almost all growth hormone (GH) cell adenomas, and prolactin (PRL)-secreting tumors express SSTR5 more than ..
  29. ncbi Somatostatin, but not somatostatin receptor subtypes 2 and 5 selective agonists, inhibits calcitonin secretion and gene expression in the human medullary thyroid carcinoma cell line, TT
    M C Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    Horm Metab Res 34:229-33. 2002
    ..are commonly used to treat symptoms in medullary thyroid carcinoma (MTC), that expresses SRIH receptors (SSTR1 to SSTR5), as does the human MTC cell line TT...
  30. doi Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents
    Urs Sprecher
    Discovery Research, Chemistry and Non Clinical Safety, F Hoffmann La Roche AG, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
    Regul Pept 159:19-27. 2010
    ..We explored the effects of two novel, non-peptidic, orally bioavailable somatostatin receptor subtype 5 antagonists named Compound A and Compound B on glycemia in animal models of type 2 diabetes after an ..
  31. ncbi Cloning of the mouse somatostatin receptor subtype 5 gene: promoter structure and function
    D F Gordon
    Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Health Sciences Center, Denver 80262, USA
    Endocrinology 140:5598-608. 1999
    ..Cloning of the sst5 gene will facilitate the mapping of basal and regulated responses at the transcriptional level...
  32. ncbi Identification and characterization of subtype selective somatostatin receptor agonists
    S P Rohrer
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Physiol Paris 94:211-5. 2000
    ..SSTR2 in inhibition of glucagon release from mouse pancreatic alpha-cells and the somatostatin subtype-5 receptor (SSTR5) as a mediator of insulin secretion from pancreatic beta-cells...
  33. ncbi Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2
    Nadder Sharif
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B6
    Endocrinology 148:2095-105. 2007
    ..These findings indicate that the presence of sst(5) in the same cells modulates trafficking and cell surface regulation of sst(2A) and cellular desensitization to the effects of SRIF...
  34. ncbi Immunohistochemical detection of somatostatin receptor (SSTR) subtypes 2A and 5 in pituitary adenoma from acromegalic patients: good correlation with preoperative response to octreotide
    Mao Takei
    Department of Neurosurgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Endocr Pathol 18:208-16. 2007
    ..The aim of this study was to determine the correlation between the expression of somatostatin receptors by immunohistochemistry and the percent suppression of GH levels in the octreotide suppression test...
  35. ncbi Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines
    Nishtman Dizeyi
    Departments of Urology and Pathology, Malmo University Hospital, Lund University, S 205 02 Malmo, Sweden
    Urol Oncol 7:91-8. 2002
    ..b>Somatostatin receptor subtype 5 was not detectable...
  36. ncbi Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes
    Ai Yu Gong
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 284:C1205-14. 2003
    ..By RT-PCR, four of five known subtypes of SSTRs (SSTR1, SSTR2A/2B, SSTR3, and SSTR4, but not SSTR5) were detected in cholangiocytes in wild-type mice...
  37. ncbi Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells
    Zhaoxu Liu
    Department of Oncology and Pathology, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Oncol Rep 20:151-4. 2008
    ..The inhibition of DNA methylation and histone acetylation resulted in the up-regulation of SSTR5 mRNA expression. The results demonstrate a positive feedback loop between SMS and its receptors...
  38. doi Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2
    Federica Barbieri
    Laboratory pf Pharmacology, Department of Oncology, Biology, and Genetics, University of Genova, Viale Benedetto XV, 2, 16132 Genova, Italy
    Endocrinology 149:4736-46. 2008
    ..SSTR2+5 activation displayed a pattern of response superimposable to that of the SSTR5 agonist alone (low potency and higher efficacy, as compared with BIM-23120)...
  39. ncbi Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy
    P Jaquet
    Interactions Cellulaires Neuroendocriniennes, UMR6544, Centre National de la Recherche Scientifique, Institut Federatif Jean Roche, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Eur J Endocrinol 153:135-41. 2005
    This study compared the potency of a somatostatin receptor (sstr)2-sstr5 analog, BIM-23244, of an sstr2-dopamine D2 receptor (sstr2-DAD2) molecule, BIM-23A387 and of new somatostatin-dopamine chimeric molecules with differing, enhanced ..
  40. doi Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study
    Tullio Florio
    Department of Oncology, Biology and Genetics, University of Genova, Viale Benedetto XV, 2, 16132 Genova, Italy
    Endocr Relat Cancer 15:583-96. 2008
    ..Cells were characterized for GH, POMC, sstr1-sstr5, total dopamine D2 receptor (D2R) (in all cases), and D2 receptor long and short isoforms (in 15 out of 38 cases) ..
  41. ncbi Short- and long-term effects of octreotide and SOM230 on GH, IGF-I, ACTH, corticosterone and ghrelin in rats
    H A Schmid
    Novartis Institutes for BioMedical Research, Oncology Research, Basel, Switzerland
    J Endocrinol Invest 28:28-35. 2005
    ..In binding experiments, SOM230 has a higher affinity to SSTR1, SSTR3 and SSTR5 and a slightly lower affinity to SSTR2 compared to octreotide...
  42. doi The role of technetium-99m-labeled octreotide acetate scintigraphy in suspected breast cancer and correlates with expression of SSTR
    Feng Wang
    Department of Nuclear Medicine, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, China
    Nucl Med Biol 35:665-71. 2008
    ..To evaluate the value of (99m)Tc-octreotide acetate (hereafter, (99m)Tc-octreotide) somatostatin receptor (SSTR) scintigraphy in the detection of primary breast cancer and to correlate with expression of SSTRs...
  43. ncbi Radioimmunoassay for somatostatin receptor type 2
    Y Hirooka
    Department of Laboratory Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, Aichi, 480 1195 Japan
    Endocr Regul 35:31-4. 2001
    ..To develop radioimmunoassay for somatostatin receptor type 2 (SSTR2) and search for its presence in certain rat tissues...
  44. ncbi Application of fluorescence recovery after photobleaching to study prestin lateral mobility in the human embryonic kidney cell
    Louise E Organ
    Rice University, Department of Bioengineering, MS 142, P O Box 1892, Houston, Texas 77251 1892, USA
    J Biomed Opt 12:021003. 2007
    ..for prestin-green fluorescent protein (GFP) as compared to a control protein, human somatostatin receptor 5 (SSTR5)...
  45. ncbi Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice
    M Z Strowski
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 141:111-7. 2000
    ..Five distinct membrane receptors (SSTR1-5) for SST are known, and at least two (SSTR2 and SSTR5) have been proposed to regulate pancreatic endocrine function...
  46. ncbi Feedback control of thyrotropin secretion in the chicken: thyroid hormones increase the expression of hypophyseal somatostatin receptor types 2 and 5
    Bert De Groef
    Laboratory of Comparative Endocrinology, Catholic University of Leuven, Naamsestraat 61, B3000 Leuven, Belgium
    Gen Comp Endocrinol 152:178-82. 2007
    We have studied the involvement of the somatostatin receptor type 5 (SSTR5) in the control of thyrotropin (TSH) release in the chicken...
  47. pmc Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer
    Cheng Zhi Qiu
    Department of General Surgery, Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
    World J Gastroenterol 12:2011-5. 2006
    ..To study the SSTR1, 2, 3, 4, 5 expression and their relationships with clinico-pathological factors, cell proliferation, Bcl-2 and p53 expression in colorectal cancer cells...
  48. ncbi Imaging of neuroendocrine tumours with gamma-emitting radiopharmaceuticals
    E Bombardieri
    Division of Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Q J Nucl Med Mol Imaging 54:3-15. 2010
    ..The subtypes sstr2 and sstr5 are the most commonly expressed in NETs...
  49. doi The levels of somatostatin receptors in causative tumors of oncogenic osteomalacia are insufficient for their agonist to normalize serum phosphate levels
    Akira Ishii
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, Japan
    Calcif Tissue Int 86:455-62. 2010
    ..The mean expression levels of SSTR1, SSTR3, and SSTR5 were similar in the OOM and non-OOM tumors...
  50. ncbi 111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors
    E B Forssell-Aronsson
    Department of Radiation Physics, Sahlgrenska University Hospital, Goteborg University, Sweden
    J Nucl Med 41:636-42. 2000
    ..The purpose of this study was to evaluate the potential for therapy of thyroid tumors using the radiolabeled somatostatin (SS) analog octreotide...
  51. ncbi Acromegaly in a patient with normal pituitary gland and somatotropic adenoma located in the sphenoid sinus
    Maria Kurowska
    Department of Endocrinology, Medical University, Lublin, Poland
    Endokrynol Pol 59:348-51. 2008
    ..somatotropic pituitary adenoma: GH(+), PRL(-), ACTH(-), TSH(-), FSH(-), LH(-), MIB1 < 1%, SSTR3(+) and SSTR5(+). Post-surgical evaluation showed normal pituitary MRI scans, GH and IGF-1 levels 0...
  52. doi Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists
    Rainer E Martin
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Medicinal Chemistry, CH 4070 Basel, Switzerland
    Bioorg Med Chem Lett 19:6106-13. 2009
    ....
  53. ncbi Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2
    K Yasuda
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Genomics 17:785-6. 1993
    The gene encoding the somatostatin receptor subtype designated as SSTR5 was mapped to human chromosome 20p11.2 by using fluorescence in situ hybridization to metaphase chromosomes...
  54. ncbi Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes
    P Jaquet
    Interactions Cellulaires Neuroendocrines, UMR 6544, Centre National de la Recherche Scientifique, Institut Federatif Jean Roche, Faculte de Medecine Nord, Marseille, France
    J Clin Endocrinol Metab 85:781-92. 2000
    Recently, studies using somatostatin (SRIF) analogs preferential for either the SRIF receptor 2 (SSTR2) or the SSTR5 subtype demonstrated a variable suppression of GH and PRL release from GH-secreting human adenomas...
  55. ncbi Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion
    Maria Chiara Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy
    J Clin Endocrinol Metab 88:2797-802. 2003
    Somatostatin (SRIF) analogs interacting with SRIF receptor subtype (SSTR) 2 and SSTR5 are known to reduce secretion in GH-secreting pituitary adenomas...
  56. ncbi PTR-3173 (somatoprim), a novel somatostatin analog with affinity for somatostatin receptors 2, 4 and 5 is a potent inhibitor of human GH secretion
    I Shimon
    Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Endocrinol Invest 27:721-7. 2004
    ..At least five distinct SS receptor (SSTR) subtypes have been cloned and termed SSTRs 1-5. Both SSTR2 and SSTR5 regulate human GH and TSH secretion...
  57. ncbi Selective activation of somatostatin receptor subtypes differentially modulates secretion and viability in human medullary thyroid carcinoma primary cultures: potential clinical perspectives
    Maria Chiara Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    J Clin Endocrinol Metab 91:2218-24. 2006
    ..We previously demonstrated that somatostatin (SRIH) reduces cell growth in the human MTC cell line, TT, which expresses all SRIH receptor (SSTR) subtypes and responds differently to selective SSTR agonists...
  58. ncbi Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion
    Maria Chiara Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    Endocr Relat Cancer 14:91-102. 2007
    ..by SRIF and pasireotide in the 'responder' group, but not in the 'non-responder' group, including NFA expressing SSTR5. SRIF and pasireotide completely blocked forskolin-induced VEGF secretion...
  59. ncbi Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach
    Rainer E Martin
    Discovery Chemistry, Lead Generation, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    J Med Chem 50:6291-4. 2007
    We disclose the first selective, nonpeptidic, small-molecule somatostatin receptor subtype 5 (SST5R) antagonists that were identified by a chemogenomics approach based on the analysis of the homology of amino acids defining the putative ..
  60. doi Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy
    Kjell E Oberg
    Department of Endocrine Oncology, University Hospital, Uppsala, Sweden
    Gastroenterology 139:742-53, 753.e1. 2010
    ..overall survival times of patients with tumors that express a high density of SSTRs, particularly SSTR2 and SSTR5. The multi-receptor somatostatin analogue SOM230 (pasireotide) and chimeric molecules that bind SSTR2 and the ..
  61. doi Feeding responses to central administration of several somatostatin analogs in chicks
    Tetsuya Tachibana
    Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama, Ehime 790 8566, Japan
    Comp Biochem Physiol A Mol Integr Physiol 158:47-51. 2011
    ..Chicks that received vapreotide and octreotide (less than 3nmol), which are agonist of SSTR2 and SSTR5, increased their food intake...
  62. ncbi Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors
    Yuji Tani
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Endocr J 58:297-303. 2011
    ....
  63. doi Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Jena, Germany
    Neuroendocrinology 94:255-64. 2011
    ..However, so far highly specific rabbit monoclonal antibodies have been developed for the sst(2) receptor only (clone UMB-1)...
  64. ncbi Somatostatin receptors 3, 4 and 5 play important roles in gallbladder cancer
    Run Sheng Guo
    Department of General Surgery, Jiading Central Hospital, Shanghai, China
    Asian Pac J Cancer Prev 14:4071-5. 2013
    Expression changes of somatostatin receptor subtypes (SSTRs) including SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5 in the development of gallbladder cancer were assessed with attention to relationships with clinical pathological characteristics...
  65. doi CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation
    Lin Wang
    Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China
    Cell Biochem Biophys 70:1011-6. 2014
    ..AFP, ENAH, KPNA2, SLC4A3; CAMK1 signal subnetwork upstream BRCA1, DKK1, GPSM2, LEF1, NR5A1, NUP62, SORT1, SSTR5, TBL3 activated CAMK1, and downstream CAMK1-activated MAP2K6, SFRP4, SSTR5, TSHB, UBE2C in HCC...
  66. pmc Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas
    Raul M Luque
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, and Hospital Universitario Reina Sofia CIBER Fisiopatología de la Obesidad y Nutrición Campus de Excelencia Internacional Agroalimentario ceiA3, 14014, Cordoba, Spain Electronic address
    Cancer Lett 359:299-306. 2015
    ....
  67. pmc Somatostatin receptor expression in small cell lung cancer as a prognostic marker and a target for peptide receptor radionuclide therapy
    Constantin Lapa
    Department of Nuclear Medicine, University Hospital Wurzburg, 97080 Wurzburg, Germany
    Oncotarget 7:20033-40. 2016
    ..PET scans were visually and semi-quantitatively assessed and compared to SSTR2a and SSTR5 expression in biopsy samples...
  68. doi Expression of somatostatin receptor 2A in medullary thyroid carcinoma is associated with lymph node metastasis
    Merima Herac
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    APMIS 124:839-45. 2016
    ..001) and degree of desmoplasia (p = 0.029). Although SSTR5 protein expression significantly correlated with advanced stages of MTCs (p = 0...
  69. ncbi Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat
    J F Bruno
    Department of Medicine, State University of New York, Stony Brook 11794
    Endocrinology 135:1787-92. 1994
    ..fed controls, whereas pituitary levels of SSTR4 and SSTR5 mRNA were unaffected. The pituitary plasma membrane SSTR concentration was reduced over 50% in FD vs. fed animals...
  70. ncbi Cloning of the mouse SSTR5 gene
    S Moldovan
    Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Surg Res 76:57-60. 1998
    ..To date the mouse SSTR5 gene has not been cloned...
  71. ncbi The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Gene 248:183-9. 2000
    ..SALPR shares the highest amount of amino acid similarity with the somatostatin (35% with SSTR5) and angiotensin receptors (31% with AT1)...
  72. ncbi Effects of aging and dietary restriction on mRNA levels of receptors for growth hormone-releasing hormone and somatostatin in the rat pituitary
    I Shimokawa
    Department of Pathology, Nagasaki University School of Medicine, Nagasaki City, Japan
    J Gerontol A Biol Sci Med Sci 55:B274-9. 2000
    ..method, we analyzed the mRNA levels of the GHRH receptor (grfr) and SRIH receptor subtype 2 (sstr2) and subtype 5 (sstr5) in anterior pituitaries of male rats fed ad libitum or 30% dietary restricted...
  73. ncbi Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 440:461-75. 2002
    ..Pancreatic insulinomas had an heterogeneous SSTR expression, while 100% of somatostatinomas expressed SSTR5 and 100% gastrinomas and glucagonomas expressed SSTR2...
  74. ncbi Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion
    Song Guang Ren
    Cedars Sinai Research Institute, University of California, Los Angeles, School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 88:4239-45. 2003
    ..GHRH (10 nM)-stimulated GH secretion (51% increase, P < 0.05) was suppressed equally by either SSTR2 or SSTR5-selective agonists (10 nM). GH suppression correlated with agonist affinity for their respective receptor subtypes...
  75. ncbi New roles of a neuropeptide cortistatin in the immune system and cancer
    Min Li
    Molecular Surgeon Research Center, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist Hospital, 6550 Fannin Street, Houston, Texas 77030, USA
    World J Surg 29:354-6. 2005
    ..CST binds to all five SS receptors (SSTR1-SSTR5) with high affinity and exerts its function mainly through SSTRs...
  76. ncbi Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists
    Renzo Cescato
    Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Berne, Switzerland
    J Nucl Med 47:502-11. 2006
    ..new immunocytochemical methods that allow characterization of trafficking of the somatostatin receptor subtype 2 (sst2), somatostatin receptor subtype 3 (sst3), and somatostatin receptor subtype 5 (sst5) in vitro at the protein level.
  77. ncbi [Correlation of somatostatin receptor expression in human hepatocellular carcinoma tissue to serum alpha-fetoprotein concentration]
    Yong mei Xie
    Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P R China
    Ai Zheng 26:688-92. 2007
    ..This study was to investigate the expression of SSTR1, SSTR2, SSTR3, SSTR4, and SSTR5 subtypes in HCC, and explore their correlations to serum AFP concentration.
  78. pmc Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
    Nicolas F Berbari
    Department of Pharmacology, Division of Human Genetics, and College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:1540-7. 2008
    ..this hypothesis we expressed chimeric receptors containing fragments of Sstr3 and Htr6 in the nonciliary receptors Sstr5 and Htr7, respectively, in ciliated cells...
  79. doi Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment
    Ana Paula M Casarini
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of Sao Paulo Medical School, Av 9 de Julho 3858 01406 100, Sao Paulo, SP, Brazil
    Pituitary 12:297-303. 2009
    ..We analyzed 39 somatotrophinomas; 49% were treated with SA. The most expressed SSTR was SSTR5, SSTR3, SSTR2, SSTR1, and SSTR4, respectively...
  80. doi Somatostatin receptor subtypes 2 and 5 mediate inhibition of egg yolk-induced gall bladder emptying in mice
    P Kaczmarek
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Interdisziplinares Stoffwechsel Centrum Endokrinologie, Diabetes und Stoffwechsel, Charité Universitätsmedizin 13353 Berlin, Germany
    Neurogastroenterol Motil 22:204-9, e66. 2010
    ..Therefore, it is believed that SSTR2 regulates gall bladder contraction; however, evidence has not been provided. Here, we evaluate the effects of SSTR1-SSTR5-selective agonists on egg yolk-induced gall bladder contraction in mice.
  81. doi Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Biother Radiopharm 25:237-43. 2010
    ..The aim of this study was to quantify expression levels of five SSTR subtypes (SSTR1-SSTR5) and correlate them with the clinical outcomes of patients with NETs who underwent SSA therapy...
  82. pmc Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer
    Fangyi Gu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:2877-87. 2010
    ..Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins...
  83. pmc (68)Ga-DOTATOC PET and gene expression profile in patients with neuroendocrine carcinomas: strong correlation between PET tracer uptake and gene expression of somatostatin receptor subtype 2
    Ingrid H Olsen
    European NET Centre of Excellence, Rigshospitalet, University of CopenhagenDenmark Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet and University of CopenhagenDenmark Department of Endocrinology, Rigshospitalet, University of CopenhagenDenmark Department of Surgical Gastroenterology, Rigshospitalet, University of CopenhagenDenmark Department of Oncology, Rigshospitalet, University of CopenhagenDenmark Department of Pathology, Rigshospitalet, University of CopenhagenDenmark
    Am J Nucl Med Mol Imaging 6:59-72. 2016
    ..89; p<0.0001 and r=0.5; p=0.021, respectively). Furthermore, SSTR2 and SSTR5 gene expression were strongly and positively correlated (r=0.57; p=0.006)...
  84. ncbi The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome
    R Sandford
    Department of Medicine, Addenbrookes Hospital, Cambridge, England, United Kingdom
    Genomics 38:84-6. 1996
    ..In addition sequences homologous to the somatostatin type V receptor (SSTR5) were identified 5' to PKD1, defining a larger syntenic region, as this gene has also been mapped to human ..
  85. pmc Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells
    Ramesh C Patel
    Fraser Laboratories, Department of Medicine, McGill University, and Royal Victoria Hospital, Montreal, QC, Canada H3A 1A1
    Proc Natl Acad Sci U S A 99:3294-9. 2002
    ..By using dual fluorescent ligands simultaneously applied to live cells monotransfected with SSTR5 (R5) or SSTR1 (R1), or cotransfected with R5 and R1, we have analyzed the ligand receptor stoichiometry and ..
  86. ncbi SSTR2 mediates the somatostatin-induced increase in intracellular Ca(2+) concentration and insulin secretion in the presence of arginine vasopressin in clonal beta-cell HIT-T15
    Henrique Cheng
    Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 USA
    Life Sci 71:927-36. 2002
    ..subtype selective agonists for SSTR1 (L-797,591), SSTR2 (L-779,976), SSTR3 (L-796,778), SSTR4 (L-803,087), SSTR5 (L-817,818) and PRL-2903, a specific SSTR2 antagonist...
  87. ncbi Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro
    Tullio Florio
    Pharmacology and Neuroscience, National Institute for Cancer Research, c o Advanced Biotechnology Center CBA, Genova, Italy
    Clin Endocrinol (Oxf) 59:115-28. 2003
    ....
  88. ncbi DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals
    Damian Wild
    Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital Basel, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 30:1338-47. 2003
    ..9 +/- 0.1 (3.3 +/- 0.2); sstr3, 8 +/- 2 (26 +/- 1.9); sstr5, 11.2 +/- 3.5 (10.4 +/- 1.6). Affinity towards sstr1 and 4 was very low or absent...
  89. ncbi Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus
    C G Goodyer
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Neuroscience 125:441-8. 2004
    ..SSTR4 is expressed in fetal brain, hypothalamus and spinal cord but not pituitary. SSTR5 mRNA is detectable in the pituitary and spinal cord by 14-16 weeks of fetal life...
  90. ncbi Evidence for differential effects of selective somatostatin receptor subtype agonists on alpha-subunit and chromogranin a secretion and on cell viability in human nonfunctioning pituitary adenomas in vitro
    Maria Chiara Zatelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    J Clin Endocrinol Metab 89:5181-8. 2004
    Somatostatin (SRIF) analogs interacting with SRIF receptor (SSTR) subtypes SSTR2 and SSTR5 reduce hormone secretion of pituitary adenomas, but their antiproliferative effects are still controversial...
  91. ncbi Somatostatin receptors in primary human breast cancer: quantitative analysis of mRNA for subtypes 1--5 and correlation with receptor protein expression and tumor pathology
    U Kumar
    Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, H3A 1A1 Montreal, Quebec, Canada
    Breast Cancer Res Treat 92:175-86. 2005
    ..at the mRNA level in breast tumors with 91% of samples showing SSTR1, 98% SSTR2, 96% SSTR3, 76% SSTR4, and 54% SSTR5. SSTR1-5 are localized to both tumor cells and the surrounding peritumoral regions as detected by ..
  92. ncbi Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors
    Seung Kwon Yang
    Prince Henry s Institute of Medical Research, Monash University, Melbourne, Australia
    Endocrinology 146:4975-84. 2005
    ..Activation of SSTR1 and SSTR5 by their respective agonists, L-797,591 or L-817,818 (10 nM), increased K+ current amplitude, but SRIF evoked a ..
  93. ncbi Alterations in glucose homeostasis in SSTR1 gene-ablated mice
    X P Wang
    The Michael E DeBakey Department of Surgery, Baylor College of Medicine, 6550, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 247:82-90. 2006
    ..islets of SSTR1-/- mice had significantly decreased levels of somatostatin staining and a significant decrease of SSTR5 expression...
  94. doi Somatostatin receptor subtypes in human type 2 diabetic islets
    Guida M Portela-Gomes
    Department of Gastroenterology, Lisbon University, Lisbon, Portugal
    Pancreas 39:836-42. 2010
    ..The immunoreactivity to sst1 to sst5 in normal human endocrine pancreas has been described. The present study reports the expression of sst1 to sst5 in human pancreatic islets with type 2 diabetes mellitus...
  95. ncbi Does the response of GH-secreting pituitary adenomas to octreotide depend on the cellular localization of the somatostatin receptor subtypes SSTR2 and SSTR5?
    Hanna Pisarek
    Department of Neuroendocrinology, Medical University, Łódź
    Endokrynol Pol 61:178-81. 2010
    ..Currently used long-acting somatostatin analogue octreotide prefers SSTR2 and SSTR5 subtypes...
  96. doi SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors
    Hanna Pisarek
    Department of Neuroendocrinology, Medical University of Łódź, Poland
    Folia Histochem Cytobiol 48:142-7. 2010
    ..The observed pattern suggests that apart from octreotide and lanreotide, newly synthesized multiligand analogs such as SOM 230, KE 108 or SSTR 1 and SSTR 5 selective analogs could be effective in NETs treatment...
  97. pmc Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation
    Luis V Syro
    Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia
    Pituitary 15:342-9. 2012
    ..Analysis of the entire SSTR5 gene disclosed the variant c.142C>A (p...
  98. ncbi Characterization of somatostatin receptor 2 and 5 expression in operable hepatocellular carcinomas
    Shanni Li
    Department of Transplantation, Tianjin First Center Hospital, Tianjin, China
    Hepatogastroenterology 59:2054-8. 2012
    ..However, expression of somatostatin receptor (SSTR) in operable HCC is still unclear. In this study, we analyzed the expression of SSTR-2 and -5 in HBV-related HCC and compared its clinicopathological features and follow-up data...
  99. pmc G protein-coupled receptors participate in cytokinesis
    Xin Zhang
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Cytoskeleton (Hoboken) 69:810-8. 2012
    ..Understanding the molecular details of GPCRs and their interaction proteins in cytokinesis regulation will give us important clues about GPCRs signaling as well as how cells communicate with their environment during division...
  100. ncbi Resistance to octreotide LAR in acromegalic patients with high SSTR2 expression: analysis of AIP expression
    Leandro Kasuki
    Endocrinology Division, Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Arq Bras Endocrinol Metabol 56:501-6. 2012
    ..Somatostatin receptor type 2 and 5 (SSTR2 and SSTR5), and aryl hydrocarbon receptor-interacting protein (AIP) expression levels were analyzed by qPCR...
  101. doi Medical treatment of Cushing's disease
    Richard A Feelders
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:425-38. 2013
    ..Considering the deleterious effects of uncontrolled CD, there is a clear need for effective medical therapy...

Research Grants6

  1. PHARMACOLOGY OF SOMATOSTATIN RECEPTORS
    Jean Rivier; Fiscal Year: 1999
    ..and antagonist to each of the five recently discovered and cloned receptor subtypes SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5. This area of research is highly desired since selective and potent SRIF analogs are needed as tools to unravel ..
  2. Regulation of Mouse Somatostatin Receptor Subtype 5 Gene
    WHITNEY WOODMANSEE; Fiscal Year: 2004
    ..is to expand our understanding of the basic molecular mechanism(s) regulating expression of the mouse somatostatin receptor subtype 5 gene (sst5)...
  3. Intraislet Communication in Surgically-Altered Pancreas
    FRANCIS BRUNICARDI; Fiscal Year: 2007
    ..subtypes responsible for the inhibition of insulin are unknown, however, preliminary data suggest that SSTR1 and SSTR5 are important regulators of insulin secretion and that there are species differences...
  4. Somatostatin Receptor Subtype 5 Regulation of Islet Neoplasia
    FRANCIS CHARLES BRUNICARDI; Fiscal Year: 2010
    ..our SSTR5-/- mice develop INeo associated with hyperinsulinemia, hypoglycemia and PDX-1 overexpression, suggesting mSSTR5 ..
  5. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
    ..Both forms bind with high affinity to SSTR2 and SSTR5, which are expressed abundantly in islets...
  6. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..