SRD5A1

Summary

Gene Symbol: SRD5A1
Description: steroid 5 alpha-reductase 1
Alias: S5AR 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, steroid 5-alpha-reductase type I, steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Species: human

Top Publications

  1. pmc Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity
    Jeremy W Tomlinson
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, U K
    Diabetes 57:2652-60. 2008
  2. ncbi Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5alpha-reductase type 2 deficient males
    Susanne Thiele
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Lubeck, Lubeck, Germany
    Eur J Endocrinol 152:875-80. 2005
  3. ncbi Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1
    Justine A Ellis
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    J Hum Genet 50:534-7. 2005
  4. pmc Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence
    Verica Milivojevic
    Graduate Program in Neuroscience, University of Connecticut Health Center, Farmington, USA
    Alcohol Clin Exp Res 35:946-52. 2011
  5. ncbi Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women
    Mark O Goodarzi
    Department of Ob Gyn and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 91:4085-91. 2006
  6. ncbi Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates
    Tasoula Tsilchorozidou
    Departments of Endocrinology and Chemical Biochemistry, University College London Hospitals, London W1T 3AA, United Kingdom
    J Clin Endocrinol Metab 88:5907-13. 2003
  7. ncbi Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver
    Mostafa K El-Awady
    Department of Biomedical Technology, National Research Center, Cairo, Egypt
    Endocr J 51:37-46. 2004
  8. ncbi Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
    Lynn N Thomas
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Prostate 63:231-9. 2005
  9. ncbi Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    Yi Xu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4072-9. 2006
  10. ncbi Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    Motohide Uemura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 99:81-6. 2008

Research Grants

  1. John B McKinlay; Fiscal Year: 2014
  2. Aria F Olumi; Fiscal Year: 2015
  3. MEDICAL THERAPY IN BENIGN PROSTATIC HYPERPLASIA
    Michael Lieber; Fiscal Year: 2001
  4. 5 ALPHA REDUCTASE GENOTYPE, RACE PROSTATE CANCER RISK
    Laurence Kedes; Fiscal Year: 2003
  5. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
  6. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
  7. BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS
    Julianne Imperato McGinley; Fiscal Year: 2000
  8. Clinical validity and utility of genomic targeted chemoprevention of PCa
    Jianfeng Xu; Fiscal Year: 2010
  9. MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTS
    Jeanne Manson; Fiscal Year: 2001
  10. Formulated Phytosterols - A New Treatment For Benign Prostatic Hyperplasia
    CURTIS SPILBURG; Fiscal Year: 2006

Detail Information

Publications197 found, 100 shown here

  1. pmc Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity
    Jeremy W Tomlinson
    Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, U K
    Diabetes 57:2652-60. 2008
    ....
  2. ncbi Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5alpha-reductase type 2 deficient males
    Susanne Thiele
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Lubeck, Lubeck, Germany
    Eur J Endocrinol 152:875-80. 2005
    ..We investigated whether 5RI is transcribed in normal male genital skin fibroblasts (GSFs) and if the transcription is regulated by age or by androgens themselves...
  3. ncbi Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1
    Justine A Ellis
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    J Hum Genet 50:534-7. 2005
    ..1 and 2 responsible for converting testosterone to the more potent androgen dihydrotestosterone are encoded by the SRD5A1 and SRD5A2 genes, respectively...
  4. pmc Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence
    Verica Milivojevic
    Graduate Program in Neuroscience, University of Connecticut Health Center, Farmington, USA
    Alcohol Clin Exp Res 35:946-52. 2011
    ....
  5. ncbi Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women
    Mark O Goodarzi
    Department of Ob Gyn and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 91:4085-91. 2006
    Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5alpha-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS).
  6. ncbi Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates
    Tasoula Tsilchorozidou
    Departments of Endocrinology and Chemical Biochemistry, University College London Hospitals, London W1T 3AA, United Kingdom
    J Clin Endocrinol Metab 88:5907-13. 2003
    ..This dysregulation does not seem to be the primary cause of PCOS because no correlation was found between serum androgen levels or urinary excretion of androgens with measurements of either 5alpha-R or 11beta-HSD1 activities...
  7. ncbi Steroid 5alpha reductase mRNA type 1 is differentially regulated by androgens and glucocorticoids in the rat liver
    Mostafa K El-Awady
    Department of Biomedical Technology, National Research Center, Cairo, Egypt
    Endocr J 51:37-46. 2004
    ..Moreover, our findings appear to indicate that regulation of 5alphaR1 gene is primarily at the post-transcriptional level...
  8. ncbi Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
    Lynn N Thomas
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Prostate 63:231-9. 2005
    ..However, inhibition of both 5alphaR isoenzymes causes a greater decrease in serum DHT. The aim of this study was to assess differential expression of these enzymes at various stages of PCa development...
  9. ncbi Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    Yi Xu
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:4072-9. 2006
    ..e., SRD5A1 and SRD5A2)...
  10. ncbi Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    Motohide Uemura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 99:81-6. 2008
    ....
  11. doi Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
    Johannes Hofland
    Departments of Internal Medicine, Urology, and Pathology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Cancer Res 70:1256-64. 2010
    ..Enzymes that convert androstenedione to testosterone (AKR1C3) and testosterone to dihydrotestosterone (DHT; SRD5A1) were abundantly expressed...
  12. ncbi 5Alpha-reductase type 1 and aromatase in breast carcinoma as regulators of in situ androgen production
    Takashi Suzuki
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    Int J Cancer 120:285-91. 2007
    ..Aromatase inhibitors may be more effective in these patients, possibly due to increasing local DHT concentration with estrogen deprivation...
  13. pmc Racial differences in the androgen/androgen receptor pathway in prostate cancer
    C A Pettaway
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    J Natl Med Assoc 91:653-60. 1999
    ..Collectively, these data strongly suggest racial differences within the androgen/androgen receptor pathway not only exist but could be one cause of clinically observed differences in the biology of prostate cancer among racial groups...
  14. ncbi Molecular basis of androgen insensitivity
    A O Brinkmann
    Department of Endocrinology and Reproduction, Erasmus University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Endocrinol 179:105-9. 2001
    ..Differential diagnosis of AIS is possible with syndromes presenting with almost similar phenotypes but with a completely different molecular cause...
  15. doi Novel compound heterozygous mutations in the SRD5A2 gene from 46,XY infants with ambiguous external genitalia
    Felipe Vilchis
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Del Tlalpan, Mexico, DF CP 14000, Mexico
    J Hum Genet 53:401-6. 2008
    ..This further underscores that exon 4 of SRD5A2 may be a site prone to inactivating mutations...
  16. ncbi A novel missense mutation of 5-alpha reductase type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family
    Mithat Bahceci
    Department of Endocrinology, University of Dicle, School of Medicine, Diyarbakir, Turkey
    Urology 66:407-10. 2005
    ..To analyze the steroid 5-alpha reductase type 2 gene (SRD5A2) in 2 siblings with severe male pseudohermaphroditism suspected to have 5-alpha reductase deficiency in a Turkish family...
  17. doi Undervirilization in XY newborns may hide a 5α-reductase deficiency: report of three new SRD5A2 gene mutations
    L Maimoun
    Service d Hormonologie, Hopital Lapeyronie, CHU Montpellier et UMI, Montpellier, France
    Int J Androl 33:841-7. 2010
    ..Early molecular diagnosis is indispensable for the crucial decision of the newborn's sex of rearing...
  18. ncbi A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities
    J Hasserodt
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem 8:995-1003. 2000
    ..Surprisingly, an inhibition study showed that the isomer with the inverted configuration at the N-oxide bound more strongly to this catalytic antibody...
  19. ncbi The valine allele of the V89L polymorphism in the 5-alpha-reductase gene confers a reduced risk for hypospadias
    Hanh T T Thai
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    J Clin Endocrinol Metab 90:6695-8. 2005
    ..Hypospadias is one of the most common malformations in man, with an incidence of 1:300 in newborn boys. No gene has been identified that causes isolated hypospadias, but the androgenic influence is important during male genital development...
  20. ncbi Aromatase, steroid-5-alpha-reductase type 1 and type 2 mRNA expression in gonads and in brain of Xenopus laevis during ontogeny
    R Urbatzka
    Department of Inland Fisheries, Leibniz Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587 Berlin, Germany
    Gen Comp Endocrinol 153:280-8. 2007
    ..of sexual differentiation of amphibians, we determined the mRNA expression of steroid-5-alpha-reductase type1 (Srd5a1), type2 (Srd5a2) and aromatase (Aro) during ontogeny starting from the egg and ending after completion of ..
  21. pmc Isolated micropenis reveals partial androgen insensitivity syndrome confirmed by molecular analysis
    Amrit Bhangoo
    Pediatric Endocrinology Division of Maimonides Infants and Children s Hospital of Brooklyn, Children s Hospital at SUNY Downstate, Brooklyn, NY 11219, USA
    Asian J Androl 12:561-6. 2010
    ..This underlines the importance of including AR gene analysis in the evaluation of isolated micropenis with normal plasma T to ensure proper management of the patient and appropriate genetic counseling for the family...
  22. pmc Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2)
    R Anwar
    Department of Medicine, University of Leeds
    Mol Pathol 50:51-2. 1997
    ..This mutation produces an amino acid change from glutamic acid to lysine, and may affect the ability of the enzyme to bind its co-factor...
  23. ncbi Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors
    Olivier Cussenot
    CeRePP, Tenon Hospital, Paris, France
    Eur Urol 52:1082-7. 2007
    ....
  24. ncbi A common polymorphism of the SRD5A2 gene and transsexualism
    Eva Katrin Bentz
    Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria
    Reprod Sci 14:705-9. 2007
    ..6; OR, 0.61; 95% CI, 0.11-3.32). Of note, there is no gender-specific genotype distribution among controls. The SRD5A2 Val89Leu SNP is not associated with transsexualism, refuting SRD5A2 as a candidate gene of transsexualism...
  25. doi Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?
    Loes F M van der Zanden
    Department of Epidemiology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 95:2384-90. 2010
    ..Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in studies of small sample size. Most of these associations have not been replicated...
  26. ncbi Secretion of pregnane compounds from follicular and luteal ovaries in rats
    T Sawada
    Department of Animal Reproduction, College of Agriculture, University of Osaka Prefecture, Japan
    Horm Metab Res 20:100-2. 1988
    ....
  27. ncbi Clinical, biochemical, and genetic findings in a large pedigree of male and female patients with 5 alpha-reductase 2 deficiency
    Z Hochberg
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    J Clin Endocrinol Metab 81:2821-7. 1996
    ..A homozygous point mutation was identified in exon 1, leading to a thymidine for adenine substitution, predicting amino acid substitution of leucine for glutamine at position 55...
  28. ncbi Genetic impact on prostate anatomical variability during ageing: role of CYP17, SRD5A2 and androgen receptor genes polymorphisms
    Stephane Larre
    Centre de Recherche pour les Pathologies Prostatiques EA3104, France
    BJU Int 100:679-84. 2007
    ....
  29. doi Cloning and differential expression of steroid 5 alpha-reductase type 1 (Srd5a1) and type 2 (Srd5a2) from the Harderian glands of hamsters
    Luis Ramos
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Gen Comp Endocrinol 166:388-95. 2010
    ..In this study, we isolated specific cDNAs for 5 alpha-reductase 1 (Srd5a1) and 5 alpha-reductase 2 (Srd5a2), determined their sequences and investigated their expression in the HG of both ..
  30. ncbi V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression
    R K Nam
    Division of Urology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Urology 57:199-204. 2001
    ..We examined whether this polymorphism predicts the presence of prostate cancer in 320 men without cancer who underwent biopsy and cancer progression in 318 men who underwent radical prostatectomy...
  31. pmc Codon 89 polymorphism in the human 5 alpha-reductase gene in primary breast cancer
    A Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Br J Cancer 84:760-7. 2001
    ..Long-term-outcome studies are needed to investigate the relevance of this polymorphism to breast cancer susceptibility...
  32. pmc A missense substitution A49T in the steroid 5-alpha-reductase gene (SRD5A2) is not associated with prostate cancer in Finland
    N Mononen
    Laboratory of Cancer Genetics, Dept of Clinical Chemistry, Institution of Medical Technology, University of Tampere and Tampere University Hospital, P O Box 2000, Tampere, FIN 33521, Finland
    Br J Cancer 84:1344-7. 2001
    ..Our results argue against a prominent role of the A49T variant as a genetic risk factor for prostate cancer development and progression in the Finnish population...
  33. ncbi The V89L polymorphism in the 5-alpha-reductase type 2 gene and risk of breast cancer
    Carla H van Gils
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 12:1194-9. 2003
    ..10). In conclusion, our findings do not provide evidence for an important role of the V89L polymorphism in the etiology of breast cancer. However, in breast cancer patients, the LL genotype may be associated with unfavorable prognosis...
  34. ncbi Associations between polymorphisms in the steroid 5-alpha reductase type II (SRD5A2) gene and benign prostatic hyperplasia and prostate cancer
    Muhammad T Salam
    Department of Preventive Medicine, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA
    Urol Oncol 23:246-53. 2005
    ..03). Prostate cancer and BPH were not associated with the alanine-49 to threonine single nucleotide polymorphism and the (TA)n repeat. These results suggest that the SRD5A2 gene may play an important role in both BPH and prostate cancer...
  35. ncbi Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Res 66:11077-83. 2006
    ..Carriers of five high-risk alleles in the AR, CYP17, and SRD5A2 genes are at approximately 2-fold excess risk to develop prostate cancer...
  36. doi Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review
    Jun Li
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K55, Atlanta, GA 30341, USA
    Am J Epidemiol 171:1-13. 2010
    ..Analysis of well-designed population-based studies with pathway-based arrays containing common genetic variants could be useful for identifying genetic factors in prostate cancer...
  37. ncbi Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 56:37-44. 2003
    ..However, the role of SRD5A2 sequence variants in the susceptibility to hereditary prostate cancer (HPC) has not been evaluated to date...
  38. doi The SRD5A2 V89L polymorphism is associated with severity of disease in men with early onset prostate cancer
    John K Scariano
    Department of Pathology and Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Prostate 68:1798-805. 2008
    ..The more common and rapid catalytic isoform contains a valine residue at position 89; the slower-catalytic variant contains leucine at this position...
  39. ncbi Association between two polymorphisms in the SRD5A2 gene and serum androgen concentrations in British men
    Naomi E Allen
    Cancer Research United Kingdom Epidemiology Unit, University of Oxford, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, United Kingdom
    Cancer Epidemiol Biomarkers Prev 12:578-81. 2003
    ..0003). Because of the rarity of this variant allele, larger studies are needed to additionally clarify the role of the A49T polymorphism in androgen metabolism...
  40. ncbi [Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate cancer]
    Ming Tong
    Institute of Urology, First Hospital, Peking University, Beijing 100034, China
    Zhonghua Wai Ke Za Zhi 42:1493-6. 2004
    ..The correlation were studied between testosterone 5-alpha-reductase II (SRD5A2) gene polymorphisms and prognosis factors...
  41. ncbi A common polymorphism within the steroid 5-alpha-reductase type 2 gene and timing of menopause in Caucasian women
    Ambros Huber
    Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur J Obstet Gynecol Reprod Biol 125:221-5. 2006
    ..We evaluated the association between a common polymorphism of the steroid 5-alpha-reductase type 2 gene (SRD5A2) involved in androgen metabolism and the timing of menopause...
  42. doi Longer (TA)n repeat but not A49T and V89L polymorphisms in SRD5A2 gene may confer prostate cancer risk in South Indian men
    Singh Rajender
    Endocrinology Division, Central Drug Research Institute, Lucknow, India
    J Androl 30:703-10. 2009
    ..Our study emphasizes that the (TA)(9) allele might confer certain PC risk but that A49T and V89L polymorphisms do not confer PC risk in South Indian men...
  43. pmc Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697 3900, USA
    Exp Cell Res 315:3133-9. 2009
    ....
  44. doi SRD5A2 V89L polymorphism and prostate cancer risk: a meta-analysis
    Chunyang Wang
    Tianjin Institute of Urological Surgery, Tianjin Key Laboratory of Urology, Tianjin Medical University, Tianjin, China
    Prostate 70:170-8. 2010
    ..To precisely estimate the relationship with more statistical power, a meta-analysis was performed...
  45. ncbi Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis
    Atsuko Shibata
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5405, USA
    Prostate 52:269-78. 2002
    ..Cytosine-adenine-guanine repeat length of the androgen receptor gene and the A49T and V89L polymorphisms of the 5 alpha-reductase (SRD5A2) gene have been associated with prostate cancer...
  46. doi [Genetic determinants of anatomical variants of the prostate]
    H Hamadeh
    CeRePP EA3104, Universite Paris VII, Paris, France
    Prog Urol 18:214-22. 2008
    ..The authors evaluated the correlation between specific gene polymorphisms involved in androgen and oestrogen synthesis and gross (prostatic weight) and microscopic anatomy (stroma/epithelium ratio) of the prostate during ageing...
  47. ncbi Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer
    K Wako
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Pathol 61:448-54. 2008
    ..The association between the expression of androgen receptor (AR) or androgen-converting enzymes and malignant potential in prostate cancer (PCa) was examined...
  48. ncbi Timing of neutrophil activation and expression of proinflammatory markers do not support a role for neutrophils in cervical ripening in the mouse
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 74:236-45. 2006
    ..cell migration in cervix through comparisons between wild-type mice and steroid 5alpha-reductase type 1 null mice (Srd5a1-/-), which fail to undergo cervical ripening due to insufficient local progesterone metabolism...
  49. doi Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer
    Kakoli Das
    Cancer Science Institute, Department of Pathology, National University Health System, National University of Singapore, 28 Medical Drive, Singapore
    Endocr Relat Cancer 17:757-70. 2010
    The biological role of steroid 5alpha-reductase isozymes (encoded by the SRD5A1 and SRD5A2 genes) and angiogenic factors that play important roles in the pathogenesis and vascularization of prostate cancer (PC) is poorly understood...
  50. doi Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus
    Tetsuya Kimoto
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153 8902, Japan
    Endocrinology 151:5795-806. 2010
    ..The relative expression levels of these enzymes/receptors at PD1 were Srd5a1 > Star > Ar ∼ Hsd17b4 ∼ Hsd17b1 ∼ Hsd17b7 ∼ Esr1 ∼ Srd5a2 > Hsd17b3 > Esr2 > Cyp11a1 > ..
  51. ncbi [Enzyme inhibition in the drug therapy of benign prostatic hyperplasia]
    J Drsata
    Farmaceutická fakulta UK, Hradec Kralove
    Cas Lek Cesk 141:630-5. 2002
    ..Inhibition of the "aromatase" complex, which catalyzes transformation of androgens to estrogens, may contribute to the complexity of phytotherapeutic effects...
  52. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
    ..AAS-induced increment of muscle tissue can be attributed to hypertrophy and the formation of new muscle fibres, in which key roles are played by satellite cell number and ultrastructure, androgen receptors and myonuclei...
  53. ncbi A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors GI198745 and finasteride
    P O Gisleskog
    Division of Clinical Pharmacology, GlaxoWellcome Research and Development, Middlesex, England
    Clin Pharmacol Ther 64:636-47. 1998
    ....
  54. ncbi Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings
    Regina M Martin
    Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular LIM 42, Divisão de Endocrinologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, 01065 970 São Paulo, Brasil
    J Clin Endocrinol Metab 88:3027-34. 2003
    ..Genetic linkage to the steroid 5alpha-reductase type 1 gene (SRD5A1) was ruled out in this family...
  55. ncbi Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase inhibitor
    S Prahalada
    Department of Safety Assessment, Merck Research Laboratory, West Point, Pennsylvania 19486, USA
    Prostate 35:157-64. 1998
    ..Therefore, studies were designed to determine the differences in intraprostatic hormonal levels, morphology, and 5alphaR activity in different lobes of the rat prostate...
  56. ncbi Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action
    Mario A Eisenberger
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Urology 63:114-9. 2004
    ..To study the safety, pharmacokinetics, biologic activity, and preliminary efficacy of the bispecific 5-alpha-reductase inhibitor (LY320236) in prostate cancer...
  57. ncbi In vitro androgen-induced growth and morphogenesis of the Wolffian duct within urogenital ridge
    M Tsuji
    Department of Anatomy, University of California, San Francisco 94143
    Endocrinology 128:1805-11. 1991
    ..These data suggest that T is an important hormone in the development of the upper portion of WDs, although it is not possible to exclude a role for DHT in the development of the epididymis...
  58. ncbi 5 alpha-reductase activity in the human hair follicle concentrates in the dermal papilla
    W Eicheler
    Philipp University, Department of Dermatology, Marburg, Germany
    Arch Dermatol Res 290:126-32. 1998
    ..These results indicate that the androgen response of hair follicles depends on a differentiated intrafollicular androgen metabolism and that the dermal papilla might be a primary target in this process...
  59. ncbi Proscar (Finasteride) inhibits 5 alpha-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck (Echinodermata: Echinoidea)
    K M Wasson
    Department of Biology, University of Alabama at Birmingham 35294 1170, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:425-31. 1998
    ..These data suggest that finasteride may be used to selectively and chemically ablate 5 alpha-reduced androgen synthesis in the gonads of L. variegatus...
  60. pmc Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride
    R Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, University of Ancona, Ospedale Regionale, Italy
    J Clin Pathol 52:350-4. 1999
    ..Finasteride, a 5-alpha-reductase inhibitor, is used as a chemopreventive agent because it blocks the conversion of testosterone to its byproduct which promotes prostate tumour growth...
  61. ncbi Finasteride delays the onset of maternal behavior in primigravid rats
    Phyllis E Mann
    Department of Biomedical Sciences, Peabody Pavilion, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Rd, N Grafton, MA 01536, USA
    Physiol Behav 88:333-8. 2006
    ..03). These results suggest that the inhibition of maternal behavior by progesterone during pregnancy is not due to its conversion to allopregnanolone...
  62. ncbi Changes in 5 alpha- and 5 beta-reductase pathways of aldosterone metabolism by dietary sodium
    J Gorsline
    Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906
    Am J Hypertens 1:272-5. 1988
    ..These studies demonstrate that dietary Na+, a known regulator of aldosterone synthesis, may also regulate enzymes involved in aldosterone metabolism in peripheral tissues...
  63. ncbi Pharmacogenetics of human androgens and prostatic diseases
    G Novelli
    Dipartimento di Biopatologia e Diagnostica per Immagini, Universita di Roma Tor Vergata, 00133 Roma, Italy
    Pharmacogenomics 2:65-72. 2001
    ..Pharmacogenomic investigation of constitutional and somatic DNA changes in human genes predisposing to cancer may lead to significant advances in chemoprevention, presymptomatic diagnosis and improved treatment of PCa...
  64. ncbi The feasibility of quantitative analysis of androgen metabolism by use of single dermal papillae from human hair follicles
    S Niiyama
    Department of Dermatology, Philipp University, Marburg, Germany
    Exp Dermatol 10:124-7. 2001
    ..Therefore the use of only one or two DP is at present not a reliable tool to analyze 5aR activity ex vivo...
  65. pmc Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients
    K Margiotti
    Dipartimento di Biopatologia e Diagnostica per Immagini, Sezione di Genetica, Universita Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Dis Markers 16:147-50. 2000
    ..In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus...
  66. pmc Altered balance between the 5 alpha-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins
    C C Slater
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Assist Reprod Genet 18:527-33. 2001
    ..To evaluate androgen production and metabolism during controlled ovarian hyperstimulation...
  67. ncbi Production rates of dihydrotestosterone in healthy men and women and in men with male pattern baldness: determination by stable isotope/dilution and mass spectrometry
    H Vierhapper
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 86:5762-4. 2001
    ..In the majority of men with male pattern baldness endogenous production of DHT is markedly increased, providing a rationale for therapeutic 5 alpha-reductase inhibition in this disorder...
  68. ncbi [Drug therapy of benign prostatic hyperplasia. Is combination therapy with 5 alpha-reductase inhibitors and alpha-receptor blockers effective?]
    W Horninger
    Universitatsklinik fur Urologie, Anichstrasse 35, A 6020 Innsbruck, Osterreich
    Urologe A 41:442-6. 2002
    ..Yet, it can be assumed that in symptomatic patients with prostate volumes of more than 60 ml combination therapy may indeed prove more effective...
  69. ncbi Benign prostatic hyperplasia: from A - Z
    Mostafa M Elhilali
    Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Can J Urol 10:1799-802. 2003
    ..The journey has been long and exciting and we are sure Ernie Ramsey enjoyed being in the forefront of the evolution...
  70. ncbi [Is tumour grade applicable to finasteride-treated prostate cancer?]
    Vincent Molinie
    Fondation Hopital Saint Joseph, Paris, France
    Prog Urol 15:387-91. 2005
    ....
  71. ncbi [Novel therapeutics strategies in benign hypertrophy of prostate management]
    Th Roumeguere
    Service d Urologie, Hopital Erasme, Bruxelles
    Rev Med Brux 26:S407-11. 2005
    ..These results are necessary in order to better define the interest and the role of the inhibition of 5-alpha-reductase in a strategic attitude of prostate cancer prevention...
  72. ncbi Effects of prenatal stress on the activity of an enzyme involved in neurosteroid synthesis during the "critical period" of sexual differentiation of the brain in male rats
    N E Ordyan
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034 St Petersburg, Russia
    Neurosci Behav Physiol 35:931-5. 2005
    ..The possible involvement of neurosteroids in the actions of prenatal stress on sexual differentiation of the brain is discussed...
  73. ncbi Comparative analysis of alpha-blocker utilization in combination with 5-alpha reductase inhibitors for enlarged prostate in a managed care setting among Medicare-aged men
    Muta M Issa
    Department of Urology, Emory University, 1670 Clairmont Rd, Decatur, GA 30033, USA
    Am J Manag Care 14:S160-6. 2008
    ..To evaluate the likelihood of alpha-adrenergic antagonist (alpha-blocker) discontinuation in combination with dutasteride or finasteride among patients aged > or =65 years with enlarged prostate...
  74. doi Evaluation of MENT on primary cell cultures from benign prostatic hyperplasia and prostate carcinoma
    Patricia Mendoza
    Laboratory of Molecular and Cellular Andrology, Physiology and Biophysics Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Int J Androl 32:607-15. 2009
    ..Furthermore, the fall of endogenous concentration of T during MENT treatment anticipates that this androgen will be of low impact for the prostate...
  75. pmc Androgen resistance in squirrel monkeys (Saimiri spp.)
    Katherine L Gross
    Department of Pharmacology, University of South Alabama, Mobile, AL, USA
    Comp Med 58:381-8. 2008
    ..Therefore, the high androgen levels in squirrel monkeys likely compensate for their relatively low 5 alpha-reductase activity during the breeding season and AR insensitivity resulting from low cellular levels of FKBP52...
  76. doi Changes in human placental 5alpha-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure
    Thi T Vu
    Mothers and Babies Research Centre and School of Biomedical Sciences, John Hunter Hospital Campus, University of Newcastle, Callaghan, NSW 2308, Australia
    Reprod Fertil Dev 21:599-607. 2009
    ..These findings suggest that the preterm neonate may have lower developmental exposure to 5alpha-reduced steroids and may lack steroid-mediated neuroprotection depending on fetal sex...
  77. ncbi What's best for your patient with BPH?
    Randall H Neal
    Offutt Air Force Base, Omaha, NE, USA
    J Fam Pract 58:241-7. 2009
    ..Consider surgery for patients with severe obstructive symptoms who have not benefited from medical therapy or who prefer surgery as first-line treatment...
  78. doi Activity of dutasteride plus ketoconazole in castration-refractory prostate cancer after progression on ketoconazole alone
    Oliver Sartor
    Dana Farber Cancer Institute, Boston, MA, USA
    Clin Genitourin Cancer 7:E90-2. 2009
    ..We hypothesized that SRDA5 inhibition in combination with ketoconazole would mitigate progression after treatment with ketoconazole alone...
  79. doi A widespread population study of actual medical management of lower urinary tract symptoms related to benign prostatic hyperplasia across Europe and beyond official clinical guidelines
    Jean Nicolas Cornu
    Department of Urology, Tenon Hospital, Groupe Hospitalo Universitaire EST, Assistance Publique Hopitaux de Paris AP HP, University Paris VI, Paris, France
    Eur Urol 58:450-6. 2010
    ..alpha(1)-Blockers and 5 alpha-reductase inhibitors (5-ARIs) are the two classes of drugs recommended by the European Association of Urology guidelines for the medical management of LUTS/BPH...
  80. doi Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial
    Andreas Suter
    Medical Department, A Vogel Bioforce AG, Roggwil, Switzerland
    Phytother Res 27:218-26. 2013
    ..This was the first trial with saw palmetto to show improvement in BPH symptoms and SDys as well. [Corrections made here after initial online publication.]..
  81. doi [5 alpha-reductase inhibitors and prostate cancer: a statement of the Committee of Cancerology of the French Association of Urology]
    P Eschwege
    Service d Urologie, CHU de Nancy, Avenue de Bourgogne, 54500 Vandœuvre lès Nancy, France
    Prog Urol 22:555-60. 2012
    ..Two randomised trials and negative conclusion of the FDA about inhibitors of 5 alpha-reductase in prevention of prostate cancer need a revision of the indications of these drugs...
  82. doi Prostate cancer chemoprevention
    Gurdarshan S Sandhu
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Oncol 40:276-85. 2013
    ..Conclusive evidence for the chemopreventive benefit of nutrients or vitamins is lacking, whereas the future role of 5ARIs remains to be clarified. ..
  83. doi Medical treatment for biochemical relapse after radiotherapy
    L Quero
    Service de cancérologie radiothérapie, Hopital Saint Louis, 1, avenue Claude Vellefeaux, 75475 Paris, France
    Cancer Radiother 18:540-4. 2014
    ..In conclusion, the judicious use of a medical treatment for biochemical relapse is still debated. Given the natural history of this clinical situation, a simple surveillance is justified in many cases...
  84. doi Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or β-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome
    Manuel Maliqueo
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden Laboratorio de Endocrinología y Metabolismo, Departamento de Medicina Occidente, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Mol Cell Endocrinol 412:159-69. 2015
    ..EA also increased cortical bone mineral density. Propranolol decreased ovarian expression of Foxo3, Srd5a1, and Hif1a...
  85. ncbi BPH update: medical versus interventional management
    Udi Blankstein
    Department of Urology, McMaster University, Hamilton, Ontario, Canada
    Can J Urol 23:10-5. 2016
    ..This review will summarize the management of this common disorder and is designed to aid the generalist with the pertinent information needed to provide excellent care. ..
  86. pmc Comparison of the Effects of Dibutyl and Monobutyl Phthalates on the Steroidogenesis of Rat Immature Leydig Cells
    Linxi Li
    Center of Scientific Research, The Second Affiliated Hospital and Yuying Children s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
    Biomed Res Int 2016:1376526. 2016
    ..The direct actions of DBP or MBP on CYP11A1, CYP17A1, SRD5A1, and AKR1C14 activities were measured...
  87. doi Transcript levels of genes implicated in steroidogenesis in the testes and fat tissue in relation to androstenone accumulation in fat of pubertal pigs
    A Robic
    GenPhySE, Universite de Toulouse, INRA, INPT, ENVT, Castanet Tolosan 31320, France Electronic address
    Domest Anim Endocrinol 57:1-9. 2016
    ..the transcriptional activity of the SRD5A2 and SRD5A3 genes but the high correlation coefficient with that of the SRD5A1 gene (r = 0.62, P < 0...
  88. pmc Molecular Mechanisms Elicited by d-Aspartate in Leydig Cells and Spermatogonia
    Maria Maddalena Di Fiore
    Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universit and 224 di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Int J Mol Sci 17:. 2016
    ..d-Asp modulates androgen and estrogen levels as well as the expression of their receptors in the rat epididymis by acting on mRNA levels of Srd5a1 and Cyp19a1 enzymes, hence suggesting involvement in spermatozoa maturation.
  89. ncbi Molecular analysis of androgen resistance syndromes in Egyptian patients
    M Essawi
    Human Genetics Department, National Research Center, Cairo, Egypt
    Dis Markers 13:99-105. 1997
    ..In conclusion, the study revealed two mutations previously reported in other geographically distinct populations, inferring the possibility of mutational hot spots in the genes...
  90. ncbi Influence of androgens and age on androgen receptor and 5 alpha-reductase II transcription
    O J Hellwinkel
    Department of Pediatrics, Medical University of Lubeck, Germany
    Eur J Endocrinol 143:217-25. 2000
    ..The regulation of the androgen receptor (AR) and 5 alpha-reductase II (5RII) gene in genital skin fibroblasts is of particular interest in understanding androgen-dependent embryonic formation of external male genitalia...
  91. pmc The effectiveness of reducing the daily dose of finasteride in men with benign prostatic hyperplasia
    Michael J Sullivan
    BMC Urol 2:2. 2002
    ..5 mg of finasteride daily for one year...
  92. ncbi Recent advances in hypospadias: current surgical technique and research in incidence and etiology
    B Andersen
    Children s Hospital and Medical Center, Division of Pediatric Urology, 4800 Sand Pont Way NE, PO Box 5371, CH 81, Seattle, WA 98105, USA
    Curr Urol Rep 2:122-6. 2001
    ..Investigations into the etiology of hypospadias have shown potential links to estrogen effects in utero from increased phytoestrogen intake in maternal vegetarian diets, and rare cases of genetic mutations in 5-alpha reductase type II...
  93. ncbi Evolving strategies for prostate cancer chemoprevention trials
    Ronald Lieberman
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd Room EPN 2102, Rockville MD 20852, USA
    World J Urol 21:3-8. 2003
    ..In summary, a dual strategy for CP is being developed which includes public health measures and a medical intervention approach...
  94. ncbi Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life
    D J Carbone
    Department of Urology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Int J Impot Res 15:299-306. 2003
    ..Thus, optimal treatment for men with BPH requires the use of agents that demonstrate efficacy and safety with fewer sexual side effects...
  95. ncbi Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma
    Jun Luo
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Prostate 57:134-9. 2003
    ..The therapeutic influence of SRD5A2 inhibitor finasteride on prostate cancer is currently unknown. The direction and extent of changes in SRD5A2 expression in disease tissues is a relevant issue in this regard...
  96. ncbi The role of 5-alpha-reductase inhibition as monotherapy in view of the MTOPS data
    Jaspreet S Sandhu
    Department of Urology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Curr Urol Rep 5:274-9. 2004
    ..Furthermore, long-term 5-alpha-reductase inhibitor monotherapy, although slow in onset, is a viable therapy for symptom relief in men with mild to moderate symptoms...
  97. ncbi Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord
    Christine Patte-Mensah
    Laboratoire de Neurophysiologie Cellulaire et Intégrée, Unité Mixte de Recherche 7519 Centre National de la Recherche Scientifique, Universite Louis Pasteur, 67084 Strasbourg, France
    J Comp Neurol 477:286-99. 2004
    ..These results are the first demonstrating that oligodendrocytes and neurons of the SC possess the key enzymatic complex for synthesizing potent neuroactive steroids that may control spinal sensorimotor processes...
  98. ncbi Role of phytotherapy in men with lower urinary tract symptoms
    Yan Kit Fong
    Department of Urology, University of Vienna, Vienna, Austria
    Curr Opin Urol 15:45-8. 2005
    ..This paper reviews the evidence of its efficacy in comparison with placebo, 5-alpha reductase inhibitor and alpha-1 adrenoreceptor antagonist...
  99. ncbi Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride
    Nick Makridakis
    Department of Biochemistry and Molecular Biology and Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, 2250 Alcazar Street, IGM240, Los Angeles, California 90089 9075, USA
    J Mol Endocrinol 34:617-23. 2005
    ....
  100. pmc No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned
    C Leigh Pearce
    1Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hum Mol Genet 17:2456-61. 2008
    ..Overall, this report highlights the importance of rigorous genotyping quality control measures and replication efforts in genetic association studies...
  101. doi Progesterone is extensively metabolized in osteoblasts: implications for progesterone action on bone
    M Quinkler
    Clinical Endocrinology, Internal Medicine, Center for Gastroenterology, Hepatology and Endocrinology, Charite Campus Mitte, Charite University Medicine Berlin, Chariteplatz 1, Berlin, Germany
    Horm Metab Res 40:679-84. 2008
    ..Conversely, osteoblasts have the capacity to convert progestogens to metabolites reported to have anabolic actions through the estrogen receptor...

Research Grants62

  1. John B McKinlay; Fiscal Year: 2014
    ..The public health relevance of the proposal is substantial given the common occurrence of prCA and the urgent need for more information regarding high-grade prCAs and breast cancers potentially caused by 5-ARIs. ..
  2. Aria F Olumi; Fiscal Year: 2015
    ..Recognition of mechanisms that regulate expression of 5-1 reductase 2 will lead to identification of newer compounds and better targeted therapies for BPH and reduce the rates of invasive therapies for this benign condition. ..
  3. MEDICAL THERAPY IN BENIGN PROSTATIC HYPERPLASIA
    Michael Lieber; Fiscal Year: 2001
    ....
  4. 5 ALPHA REDUCTASE GENOTYPE, RACE PROSTATE CANCER RISK
    Laurence Kedes; Fiscal Year: 2003
    ....
  5. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..The long-term goal of this project is to define the mechanism by which equol acts to inhibit the pathological growth of the prostate gland ..
  6. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
    ..B) Prostatic cancer cells treated with either control vehicle, testosterone, DHT, testosterone plus 5alpha-reductase inhibitors, and DHT plus 50:-reductase inhibitors. ..
  7. BPH AND PROSTATE CA IN 5A-REDUCTASE-2 DEFICIENT CARRIERS
    Julianne Imperato McGinley; Fiscal Year: 2000
    ..Studies will also continue on male pseudohermaphrodites who are homozygous for the 5-alpha-reductase-2 gene, as it pertains to prostate size, PSA determination and secondary sexual hair distribution. ..
  8. Clinical validity and utility of genomic targeted chemoprevention of PCa
    Jianfeng Xu; Fiscal Year: 2010
    ..This would lead to a significant decrease in prostate cancer diagnoses and greatly reduce the burden to the individual and society. ..
  9. MOLECULAR EPIDEMIOLOGY OF BIRTH DEFECTS
    Jeanne Manson; Fiscal Year: 2001
    ..The research proposal is an extension of the training component and exemplifies how molecular, genetic and epidemiologic approaches can be combined to study the etiology of birth defects. ..
  10. Formulated Phytosterols - A New Treatment For Benign Prostatic Hyperplasia
    CURTIS SPILBURG; Fiscal Year: 2006
    ..Because of the acknowledged safety of plant sterols, the proposed product will be cost effective, free of side effects and available over the counter. [unreadable] [unreadable] [unreadable]..
  11. STEROID 5 ALPHA REDUCTASE--STRUCTURE/FUNCTION
    Shutsung Liao; Fiscal Year: 2000
    ..A recently developed photoaffinity-label will be used to identify amino acid residues in the steroid-binding domain of the isozymes. ..
  12. 5 ALPHA-REDUCTASE IN THE PRIMATE EPIDIDYMIS
    MARY MAHONY; Fiscal Year: 1999
    ..The proposed hypothesis is: activin and inhibin, by opposing actions and in concert with androgens, modulate 5alpha-reductase gene expression in the primate proximal caput epididymis with minimal effect on the more distal corpus region. ..
  13. EFFECT OF MAMMARY TUMORS ON STEROID METABOLISM
    YUSUF ABUL HAJJ; Fiscal Year: 1980
    ..The effect of surgical removal of tumor and cell-free tumor extract administration will be studied in order to determine whether the tumor contains a factor(s) responsible for altered steroid metabolism...
  14. ENDOCRINE ROLES OF STEROID 5 ALPHA REDUCTASE ISOZYMES
    David Russell; Fiscal Year: 2003
    ....
  15. Androgen Pathway and Genetic Risk of Prostate Cancer
    Noel Weiss; Fiscal Year: 2002
    ..The identification and confirmation of high-risk genetic profiles for prostate cancer could enable better screening and potential preventive interventions aimed at the gene products. ..
  16. Saw Palmetto Use and Risk of Prostate Cancer
    I Min Lee; Fiscal Year: 2004
    ..abstract_text> ..
  17. Hormonal and molecular consequences of androgen replacement on the prostate
    Stephanie T Page; Fiscal Year: 2010
    ..Nelson, MD, Associate Professor of Medicine (Oncology), University of Washington School of Medicine will co-mentor this award. ..
  18. Vascular Targeting for Imaging and Treatment of Benign Prostatic Hyperplasia
    Michael Zwick; Fiscal Year: 2009
    ....
  19. MEDICAL THERAPY OF PROSTATIC SYMPTOMS (MTOPS)
    E Crawford; Fiscal Year: 2001
    ..Adherence strategies, critical to the ultimate success and complete evaluation of trial results, include behavioral, social, and educational interventions. ..
  20. MEDICAL THERAPY FOR BPH--DATA COORDINATING CENTER
    PAMELA BURROWS; Fiscal Year: 2001
    ....
  21. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..abstract_text> ..
  22. Allium Compounds in Control of Human Prostate Cancer
    JOHN PINTO; Fiscal Year: 2003
    ....
  23. Breast cancer and HRT: genetic susceptibility within th*
    Kathleen Malone; Fiscal Year: 2006
    ..SNPs) and tagSNPs in the PGR gene, and the following progesterone metabolizing genes, AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2, and the CYP3A4 gene...
  24. Tomas Paus; Fiscal Year: 2014
    ....
  25. TESTOSTERONE EFFECTS ON GONADOTROPINS AND LIPIDS IN MEN
    CARRIE BAGATELL; Fiscal Year: 1992
    ..This knowledge may in turn be useful in developing new treatment options for diseases of the male reproductive system and in developing strategies to decrease coronary risk from lipoprotein abnormalities...
  26. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  27. METABOLISM & CONTROL OF TESTOSTERONE ANDROGENS IN MAN
    Richard Horton; Fiscal Year: 1990
    ..R. Lobo and R. Marrs we shall test whether skin minses and fibroblasts in culture synthesize 3 alpha diol G in vitro and whether formation parallels 5 alpha reductase activity in men, women, and in hirsute states...
  28. FACTORS INFLUENCING TESTICULAR DESCENT
    FREDRICK GEORGE; Fiscal Year: 1992
    ..If homogeneous cell strains can be established from gubernacular tissues, then the effects of androgens on cell proliferation and differentiation will be examined...
  29. MALE PSEUDOHERMAPHRODITISM--THE BIOLOGY OF ANDROGENS
    Julianne Imperato McGinley; Fiscal Year: 1992
    ....
  30. Hormonal Control of SBMA Pathogenesis
    Diane Merry; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. CHLORINATED HYDROCARBONS EFFECTS ON MAMMALIAN SYSTEMS
    David Kupfer; Fiscal Year: 2003
    ..CYP3A4 catalyzes the metabolism of the majority of drugs and is involved in drug-drug interaction. Understanding the mechanism of 3A4 activity would be useful in predicting drug interactions and drug:drug-metabolite interactions. ..
  32. GONADAL AND PHENOTYPIC SEX DIFFERENTIATION
    FREDRICK GEORGE; Fiscal Year: 1993
    ..A transplantation model will be developed to study the possible role of estrogen in urogenital tract development...
  33. PORT-II FOR PROSTATIC DISEASES
    Michael Barry; Fiscal Year: 1999
    ....
  34. ENDOGENOUS SEX HORMONES, GENETICS, AND PROSTATE CANCER
    Chu Chen; Fiscal Year: 2001
    ..abstract_text> ..
  35. Control of Prostate Cancer: Botanical/Drug Interactions
    Shutsung Liao; Fiscal Year: 2003
    ....
  36. NIA ACADEMIC AWARD--ANDROGEN ACTION IN THE ELDERLY MALE
    JOYCE TENOVER; Fiscal Year: 1992
    ..This research will give important information about the contribution of DHT to steroid negative feedback regulation of LHRH secretion that could be applicable to man...
  37. ANDROGEN EFFECTS ON OVULATION AND FOLLICULAR ATRESIA
    Virendra Mahesh; Fiscal Year: 1980
    ..It will also be examined if androgen induced follicular atresia can be prevented by stimulation of granulosa cell aromatase activity by FSH. ..
  38. PROSTATE CANCER IN MEXICANS AMERICANS & AFRICAN AMERICAN
    Sara Strom; Fiscal Year: 2003
    ..Understanding how genetic predisposition and exogenous exposures interact to determine prostate cancer susceptibility will allow the development of more effective ethnic-specific prevention strategies. ..
  39. IN VITRO PRESCREENING OF CLASSES OF CHEMOPREVENTIVES
    JOHN PEZZUTO; Fiscal Year: 1999
    ..There are ten agents in each mechanistic category to assay and to determine dose-related effects. ..
  40. REGULATION OF PROSTATE GROWTH BY NEURAL FACTORS
    Kevin McVary; Fiscal Year: 2001
    ..Using this model allows one to explore the limits of understanding prostatic neuroregulation, to explore neurotrophic influences on exocrine gland development, and to possibly uncover novel methods to influence prostate disease. ..
  41. N O S AND NEUROPATHIC AND ENDOTHELIAL INDUCED ED
    Kevin McVary; Fiscal Year: 2002
    ..Results of this research will aid in the understanding of how diabetic neuropathy contributes to sexual dysfunction and elucidate possible mechanisms to prevent them. ..
  42. The Efficacy of TUMT and Neoadjuvant Finasteride for BPH
    Kevin McVary; Fiscal Year: 2005
    ..We are proposing a 3-arm, placebo/sham controlled, randomized clinical trial using changes in symptoms as the primary ..
  43. PHYSICIAN AND SCIENTIST TRAINING IN UROLOGICAL RESEARCH
    Alan Wein; Fiscal Year: 2007
    ..Funding is sought for two years of support for three trainees annually. ..
  44. TRAINING IN UROLOGY
    Alan Wein; Fiscal Year: 2003
    ..At each step the trainees will be advised by experienced investigators. It is expected that in return the clinician's will offer to the laboratory insight into the fundamental clinical problems facing the specialty of urology. ..
  45. Trainee-Focusted Training for Research Integrity
    Steven Jacobsen; Fiscal Year: 2003
    ..6. Identify high frequency perceptions or frames of reference, which are substantially at odds with accepted research norms and begin designing better interventions to alter them. ..
  46. Neurosteroid Modulation of Ethanol Intake and Reward
    Matthew Ford; Fiscal Year: 2004
    ..Results from these experiments will provide valuable insights into the mechanisms underlying neurosteroid modulation of ethanol intake and reward. ..
  47. Targeting of the Androgen Receptor in Prostate Cancer
    John Isaacs; Fiscal Year: 2005
    ..These peptide prodrugs will be designed so that they are substrates for the enzymatic activity of either Prostate Specific Antigen. ..
  48. Cohort Study of Risks for Benign Prostatic Hyperplasia
    Alan Kristal; Fiscal Year: 2005
    ..Results from this study will enhance our understanding of the etiology of symptomatic BPH and could potentially be used to develop new strategies for prevention and control of this very common disease. ..
  49. Primary Care Colorectal Ca Screening Surveillance System
    Richard Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  50. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  52. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  53. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    ..Such knowledge can be applied for promoting or inhibiting these critical facets of ovarian physiology, thereby allowing us to better manage fertility, infertility, and ovarian-based disorders. [unreadable] [unreadable]..
  54. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  55. The Effects of Neuroactive Steroids on Acute Ethanol Withdrawal in Mice
    KATHERINE GILILLAND; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. INTERSTITIAL CYSTITIS TREATMENT PROTOCOLS
    Alan Wein; Fiscal Year: 2003
    ..C. patients across a large geographical area. This group's constant interaction creates a solid professional alignment that benefits patients from near and far. ..
  57. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  58. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  59. Harbor-UCLA Initiative for Minority Student Development
    Christina Wang; Fiscal Year: 2005
    ....
  60. COMPARISON OF TREATMENT EFFICACY FOR PROSTATE CANCER
    Peter Albertsen; Fiscal Year: 2002
    ....
  61. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..